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在国内贯彻落实“双碳”目标和大规模推广可再生能源的背景下，电化学储能作为提高新能源利用率的重要技术手段，近年来快速发展。但目前尚缺乏完备的大容量电化学储能电站储能效果评价平台。首先剖析了储能电池组和储能变流器模型的运行特性，采用k-means聚类算法提取电化学储能电站的等值参数并建立等值模型。其次，基于现有储能并网运行架构，以四象限变流器为核心，开发了测试大容量储能电站故障电压穿越能力和电网适应性的评价平台，以实现对大容量电化学储能电站的并网检测及运行评价。测试结果显示，提出的储能电站等值模型和大容量电化学储能电站评价平台能够在较短的仿真时间内对电化学储能电站做出较准确的评价。

遗传算法（GA）是无人艇路径规划系统中的一种有效方法，为了克服该算法易陷入局部最优早熟和收敛速度慢等缺陷，在不增加算法复杂度的前提下，基于数据驱动线性动态交叉策略提出了一种能够在最短时间内自适应动态调整控制参数的改进遗传算法（LCPGA）。与传统的遗传算法相比，LCPGA增加了种群多样性，能更有效地避免陷入局部最优，并提高了路径规划的精度、稳健性和收敛速度。仿真实验和无人艇现场试验验证了该算法具有更优良的性能，该算法可为无人艇路径规划提供一定的应用价值。

Copyright of Psychological Science is the property of Psychological Science Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of High Pressure Physics is the property of Chinese Journal of High Pressure Physics Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Coatings & Protection / Tuceng yu Fanghu is the property of Coating & Protection Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Corrosion & Protection in Petrochemical Industry is the property of Corrosion & Protection in Petrochemical Industry Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Computer Engineering & Applications is the property of Beijing Journal of Computer Engineering & Applications Journal Co Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In order to study the distribution of heat, temperature and stress fields and their mutual influence on the sliding process of the wheel-rail friction substrate, based on the G-W model, the wheel-rail friction substrate was simplified into a rough surface of micro-convex bodies with different shapes and an ideal plane, and combined with the finite element method. The results show these as follows. The interaction between the micro-convex bodies has an impact on the frictional heat generation, with the increase of the stack of spherical crown-shaped micro-convex bodies, the distribution area of the heat zone increases and the heat source decreases. The friction temperature rise decreases with the increase of the number of micro-bumps in the X -direction, and increases with the increase of the number of micro-bumps in the Z -direction, and the distribution of the heat zone is concentrated behind the sliding direction. The friction temperature rise on the rough surface of the spherical crown-shaped micro-convex body is generally higher than that of the rectangular-shaped micro-convex body. The effect of rough surface morphology on the heat source, heat zone distribution, temperature field and stress field distribution of wheel-rail friction is explored at the microscopic level to provide a theoretical basis for further research on wheel-rail interaction and ensure safe train operation. [ABSTRACT FROM AUTHOR]

Objective To evaluate the changes in surgical approaches and treatment strategies for foramen magnum (FM) meningiomas located in the anterior or anterolateral aspect of the medulla oblongata. Methods The clinical data of 72 patients suffering a meningioma attached to dura of the anterior or anterolateral FM rim admitted to General Hospital of the People's Liberation Army from January 2007 to January 2022 were analyzed retrospectively. The relevant literature were reviewed. Results Tumor removal was accomplished via a posterolateral suboccipital retrocondylar approach in all patients. Total resection was achieved in 65 patients (90%). 7 patients (10%) of subtotal resection underwent cyberknife radiosurgery. 12 cases (17%) had hypoglossal nerve dysfunction, and 8 improved within 3 months after surgery. 18 cases (25%) experienced hoarseness and/or difficulty swallowing, 15 improved within 3 months after surgery, and 1 underwent tracheotomy due to posterior cranial nerve paralysis. 1 suffered from hemiplegia due to anterior spinal artery injury. There were no surgical deaths. No tumor recurrence was observed after a mean follow-up period of 3 years (range, 12-60 months) with clinical and MRI examination. Conclusions Microsurgery via retrocondylar approach to remove anterior and anterolateral FM meningiomas can not only meet the needs of surgical exposure, but also avoid excessive bone grinding, achieving good total resection rate, low complications, and long-term satisfactory therapeutic effect. The occurrence of serious complications such as postoperative hemiplegia is mainly due to intraoperative vascular damage. [ABSTRACT FROM AUTHOR]

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Copyright of Industrial Water Treatment is the property of CNOOC Tianjin Chemical Research & Design Institute and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Control Theory & Applications / Kongzhi Lilun Yu Yinyong is the property of Editorial Department of Control Theory & Applications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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【摘要】 目的 分析公立医院高层次人才满意度调查，为提高人才满意度提出持续改进的策略。 方法 对北京市某三级甲等综合医院155名高层次人才进行问卷调查。采用Likert 5点量表赋分方法，从工作情况、职业发展、工作关系、薪酬福利和科研管理5个维度设计调查问卷。根据研究对象对各维度的满意度，进行对策研究。 结果 本研究获得有效问卷144份，问卷有效率92.90%。参与调查对象总体满意度评价得分为（77.86±11.3）分。5个维度满意度评分排序依次为：科研管理（82.16±11.56）分、工作关系（78.72±12.72）分、工作情况（77.30±15.02）分、职业发展（75.60±12.7）分和薪酬福利（75.56±13.72）分。 结论 提高公立医院高层次人才的薪酬福利、创造职业发展的平台可能是今后公立医院提高高层次人才满意度应当努力的方向。 【Abstract】 Objective To survey the satisfaction of high-level talents in a public hospital, and put forward the improvement strategy to increase the satisfaction of high-level talents. Methods A questionnaire survey was conducted in 155 high-level talents from a class 1, Grade 3 general hospital in Beijing. 5-point Likert scale was used to measure their satisfaction from 5 aspects, including working condition, career development, working relationship, salary and welfare and research management. Based on the survey results, an analysis was conducted to develop the improvement measures. Results 144 valid questionnaires (92.90%) were collected. The overall satisfaction score from the participants was 77.86±11.3. The satisfaction scores in 5 aspects were as follows: 82.16±11.56 for research management, 78.72±12.72 for working relationship, 77.30±15.02 for working condition, 75.60±12.7 for career development, and 75.56±13.72 for salary and welfare. Conclusions Improving the salary and welfare of high-level talents in public hospitals and creating a career development platform may be the direction for public hospitals to improve the satisfaction of high-level talents in the future.

Management level and user benefits have greatly contributed to agricultural machinery in recent years. The operational efficiency of agricultural machinery was commonly used to evaluate the utilization rate, operator driving ability, and management efficiency of agricultural machinery. However, the current operational efficiency of agricultural machinery cannot fully represent the overall operational efficiency of agricultural machinery. For example, although the low-power agricultural machinery has low operational efficiency, the generated benefits are not lower than that of high-power agricultural machinery, if the operating time is saturated. In addition, the quality of agricultural machinery operation can seriously affect operational efficiency. Therefore, it is necessary to consider the key influencing factors on the efficiency of agricultural machinery operations. In this study, a comprehensive and comprehensive evaluation was conducted on agricultural machinery operations. The operational efficiency was then evaluated on each agricultural machine using influencing factors. The daily operational information of each machine was taken as a piece of data on that day. The operation status of operators and agricultural machinery were checked to identify the influencing factors on the efficiency of operations, in order to improve the management level and revenue of agricultural machinery. The data was collected from the 32000 deep loosening operations of agricultural machinery. The results show that the main influencing factors on the daily operation efficiency of agricultural machinery were directly obtained, including the daily operation area, fuel consumption, operation quality, repeated operation rate, missed operation rate, and the proportion of effective operation time. The BP_Adaboost neural network (NN) training model was used to evaluate the efficiency of agricultural machinery operation. Manually grading was replaced to avoid the large workload and extremely low efficiency from the subjective factors, inconsistent standards, and labeling errors, due to the large number of agricultural machinery and the large amount of homework data. A comparison was made on the training model and manual grading to predict the remaining data. Manual scoring standards were effectively used to establish the predictive models. A small number of samples were selected to predict the operational efficiency of agricultural machinery. The low accuracy was obtained in the training model if there were too few labeled samples. If the additional labeled samples were added, manual grading was less labor-saving. Semi-supervised BP_Adaboost was utilized to evaluate the efficiency of agricultural machinery operations, where manually scoring some data was marked the daily efficiency. One part was used as training samples, whereas, another part was used as testing samples. The BP_Adaboost was then used to reduce the manual labeling of training samples for the high accuracy of the training model, where the remaining unrated data was predicted after training the model. 1 000 samples were selected from 32 000 deep loosening operation data for labeling, of which 500 were used as training samples and 500 were used as testing samples. The highest prediction accuracy was achieved in the semisupervised method for the selected experimental data when the probability threshold was 97%. If the threshold was too large, there was only a limited increase in samples; If the sample was too small, misclassified samples led to low accuracy. Therefore, there was a significant impact on the sample selection and termination in semi-supervised methods. The prediction accuracies were achieved in 93.36% and 97.03%, respectively, using the BP_Adaboost, and semi-supervised BP_Adaboost with training samples. Statistical analysis was conducted on 32 000 agricultural machinery operation data from the experiment. The effectiveness of the improved model was obtained by combining the partial power agricultural machinery with different-width machines. The operation efficiency varied greatly in the power agricultural machinery when paired with different width machines. The optimal combination of agricultural machinery was recommended to enhance the operational capabilities, according to the operational efficiency. The accuracy of the improved model was higher than that of using the BP_Adaboost alone, depending largely on the selection of the probability threshold. The generalization and standards can be expected for the different datasets and the optimal thresholds. A more reasonable probability threshold can be selected to assign different weights to various indicators for the better performance of the improved model. [ABSTRACT FROM AUTHOR]

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Copyright of Machine Tool & Hydraulics is the property of Guangzhou Mechanical Engineering Research Institute (GMERI) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

AIM: To investigate the effect of scutellarin combined with polydatin on pulmonary and bronchial injury induced by lipopolysaccharide （LPS） combined with smoking in rats and its mechanism. METHODS: Male SD rats were randomly divided into control group, model group, Huangqin Jingye-Huzhang decoction （5 g/kg） group, scutellarin （40 mg/kg） group, polydatin （60 mg/kg） group, scutellarin+polydatin （20 mg/kg+30 mg/kg, 40 mg/kg+60 mg/kg and 80 mg/kg+120 mg/kg） groups, and Guilong Kechuanning tablet （1 g/kg） group, with 10 rats each group. Chronic bronchitis model was established in 90 rats. The levels of interleukin-1β（ IL-1β）, IL-6, IL-17A, IL-10 and tumor necrosis factor-α （TNF-α） in bronchoalveolar lavage fluid （BALF） and serum were measured by ELISA, and the levels of superoxide dismutase （SOD） and malondialdehyde （MDA） in lung tissues were detected using kits. Protein content and cell counts in BALF were determined. Wet/dry（ W/D） mass ratio of the right lung was estimated, and HE staining was used to observe the pathological changes of pulmonary and bronchial tissues and score the lung tissue injury. The mRNA expression of phosphatidylinositol 3-kinase （PI3K）, protein kinase B （PKB/AKT） and mammalian target of rapamycin （mTOR） was detected by RT-qPCR. The protein levels of p-PI3K, PI3K, p-AKT, AKT, p-mTOR and mTOR were detected by Western blot. RESULTS: Compared with control group, the levels of IL-1β, IL-6, protein, leukocytes and neutrophils in BALF, the levels of IL-17A and TNF-α in serum, the content of MDA in lung tissues and the W/D mass ratio of the right lung in model group were significantly increased （P<0. 01）, while the content of IL-10 in serum and the activity of SOD in lung tissue were significantly decreased（ P<0. 01）. The protein levels of p-PI3K, p-AKT and p-mTOR were significantly up-regulated （P<0. 01）. Compared with model group, the levels of IL-1β, IL-6, protein, white blood cells and neutrophils in BALF, the levels of IL-17A and TNF-α in serum, the content of MDA in lung tissues and the W/D mass ratio of the right lung in scutellarin+polydatin （20 mg/kg+30 mg/kg, 40 mg/kg+60 mg/kg and 80 mg/kg+120 mg/kg） groups were significantly lower than those in model group（ P<0. 01 or P<0. 05）, while the content of IL-10 in serum and the activity of SOD in lung tissue were significantly increased （P<0. 01）. The pulmonary and bronchial inflammatory response was alleviated, and the injury was obviously attenuated. The protein levels of p-PI3K, p-AKT and p-mTOR were significantly down-regulated （P<0. 01）. CONCLUSION: Scutellarin combined with polydatin protects pulmonary and bronchial tissues against the injury induced by LPS combined with smoking in rats. The mechanism may be related to inhibiting the activation of PI3K/AKT/mTOR pathway, reducing oxidative stress and inhibiting inflammatory factors such as IL-17A, TNF-α, IL-1β and IL-6. [ABSTRACT FROM AUTHOR]

Oncogenic mutations are responsible for a majority of the malignancy of melanoma. Activating mutations of NRAS gene are found in 15%-20% melanoma cases, endowing the tumor cells with more aggressive phenotypes and greater difficulty to treat. The development of targeted inhibitor of mutant NRAS remains a big challenge since the mutation sites could hardly be druggable. Therefore, immune checkpoint inhibitors are currently recommended as the first-line therapy for NRAS mutant advanced melanoma albeit the response rate is still far from satisfaction. In recent years, the exploration of targeted therapy regimens has focused on the downstream pathway of NRAS, the mitogen-activated protein kinase (MAPK) pathway. A novel MEK1/2 inhibitor tunlametinib was reported to achieve an objective response rate (ORR) of 34.7% which is higher than the ORR of binimetinib in previous report. However, the phase Ⅰ trial of the pan-RAF inhibitor belvarafenib and the ERK inhibitor ulixertinib failed to show marked benefits. In the meanwhile, MEK inhibitor-based combination therapy has also achieved some progress: it was reported in the phase Ⅰb trial of the selective BRAF/CRAF inhibitor naporafenib (LXH254) combined with Trametinib in NRAS mutant melanoma that the ORR was 46.7%. The ORR of binetinib plus the cyclin-dependent kinase 4/6 (CDK4/6) inhibitor, ribociclib, was 32.5% in patients with NRAS mutation with concurrent alterations of CDKN2A, CDK4, or CCND1. The response rate of the combination of focal adhesion kinase (FAK) inhibitor, IN10018, and cobimetinib was 38.5%. On the other hand, only 27.2% of patients carrying NRAS mutation responded partially to the combined regimen of immune checkpoint inhibitor programmed death ligand-1 (PDL1) monoclonal antibody durvalumab+trametinib. In addition, some preclinical findings have also shown translational potentials: for example, heat shock protein 90 (HSP90) inhibitor XL888 and serine/threonine protein kinase 19 (STK19) inhibitors were found to inhibit the growth of NRAS mutant melanoma in animal models. This article reviewed the oncogenic roles of NRAS mutation in melanoma and the cutting-edge clinical trials for the treatment of NRAS mutant melanoma, aiming to provide alterative treatment options for clinical practice and inspire novel combination regimen. [ABSTRACT FROM AUTHOR]

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In order to facilitate studies on biological function of PUP family genes in Gossypium hirsutum, and provide candidate genes for subsequent studies on the function of PUP genes in stress resistance, in this study, 31 PUP genes were identified in Gossypium hirsutum(TM-1) genome using bioinformatics, and could be classified into 3 subfamilies according to polygenetic analysis. The results of chromosome location and gene replication analysis showed that 31 GhPUP genes were distributed on 19 chromosomes, and all PUP genes were generated by gene replication events, and the duplication type was fragment duplication. Gene structure analysis indicated that most PUP genes had only one intron, a few had two or three introns, and a few had no introns. Conserved domain analysis showed that both commonality and specificity existed between PUP proteins in different subfamilies. Cis-acting elements analysis showed that there were 18 elements in the GhPUP genes promoter region, which were classified into three categories: hormone response, stress/physical response, and plant growth and development related elements. At the same time, combined with evolutionary analysis and transcriptome data, PUP genes involved in stress response in Gossypium hirsutum were screened. [ABSTRACT FROM AUTHOR]

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Microbial fermented feed has the advantages of high nutritional value, palatability, high utilization rate and less anti-nutrient factor, which provides a feasible technical scheme for the end 'antibiotic replacement' of animal husbandry feed. In recent years, the development and application of microbial fermented feed has gradually become a research hotspot in the new era of 'no antibiotics'. Microbial fermented feed can improve the immunity and antioxidant properties of animal body, improve intestinal health and promote growth and development. In the paper, the types, advantages and application status of microbial fermented feed in cattle breeding were reviewed in order to provide reference for the research and development of microbial fermented feed. [ABSTRACT FROM AUTHOR]