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Urbanization construction has always been one of the key development directions in China, and the process of urbanization faces many risks and challenges. In the context of complex and diverse urban risks, major public health risks are one of the most significant ones in terms of impact and destructive power. The outbreak of the COVID-19 at the beginning of 2020 has evolved from a public health event to a global economic and social crisis, reflecting that China has room for further improvement in the prevention and control system of major public health risks, and the modernization of urban governance has a long way to go. It is urgent to explore the establishment of a comprehensive prevention and control system for major public health risks in cities that is in line with the process of urban development in China. The general theoretical research on risk governance in the academic community is relatively rich. The research on the public health risk prevention and control system was mainly concentrated before 2010. After the outbreak of COVID-19, China's research on major public health risk governance was once again valued by the academic community. However, the existing research is generally decentralized and fragmentation, without forming systematic theories and views. Compared to previous studies, this article focuses on the development and evolution of major public health risks, integrates the concept of “full cycle management” and dynamic prevention and control, and takes the formation of comprehensive and full cycle closed-loop management as a breakthrough and innovation. It sorts out the theoretical framework of urban major public health risk assessment and decision-making mechanisms, breaks through the limitations of existing risk governance, and achieves full cycle coordination and full process integration, To ensure the lives, health, and social stability of the people, and provide directional inspiration for further improving the governance level of major public health risks in China. Based on the background of “risk society” and the principle of risk early warning, this paper follows the process of risk occurrence and puts forward the connotation of major urban public health risks in this paper on the basis of defining relevant concepts. Guided by the concept of “full cycle management”, combined with the 4R crisis management theory, risk management theory, and holistic governance theory, the dynamic core awareness throughout the entire risk prevention and control process is integrated to construct a theoretical framework for the dynamic prevention and control of major public health risks throughout the entire process. Based on the actual situation of social gatherings, the structural and functional characteristics that should be possessed in the dynamic prevention and control of major public health event risks throughout the entire process are determined. From the perspectives of “ considering system as the core” and “risk as the main line”, this paper makes a unified top-level design plan, exploring the practical path of constructing a risk assessment system that includes risk identification, risk assessment, risk assessment, and decision support, as well as a risk control mechanism that includes emergency response and normalized control, and designs a major urban public health risk control mechanism, which transforms from traditional consequence emergency response to early risk regulation prevention and control capabilities, and thus forming a major public health risk prevention and control system of “comprehensive risk assessment, early warning, precise dynamic response control” throughout the entire process. In this paper, risk control is divided into two processes: emergency response and normalized control, that is, to design an emergency response mechanism of multi-department coordination and a normalized control mechanism of major urban public health risks, so as to solve the dilemma of emergency fragmentation and form a full-cycle closed-loop management. [ABSTRACT FROM AUTHOR]

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The medication rules of traditional Chinese medicine (TCM) prescription for the treatment of vestibular migraine (VM) based on data mining and network pharmacology were studied to explore the mechanism of action of core Chinese medicine in treating VM. The database of CNKI, Wangfang and VIP were used to screen literatures, extract data, analyze the taste, meridian tropism and efficacy of traditional Chinese medicine in the treatment of VM. IBMSPSS Model 18. 0 and IBM SPSS Statistics 21 were used to for association rules, clustering and complex network analysis to obtain the core traditional Chinese medicine for the treatment of VM. The active components and targets of core traditional Chinese medicine were searched by traditional chinese medicine systems pharmacology (TCMSP) and Swiss Target Prediction, and the disease targets of VM were obtained by Online Mendelian Inheritance in Man(OMIM) and Geencard database. The intersection targets were obtained by Venny2. 1. 0, protein interaction (PPI) and gene ontology (GO) and genome encyclopedia (KEGG) enrichment analysis were carried out by STRING and HIplot database, molecular docking verification and visualization were carried out by AutoDockTools1. 5. 7 and PyMOL. 27 literatures, 25 compound prescriptions of traditional Chinese medicine and 78 traditional Chinese medicines were selected. the core traditional Chinese medicines were licorice, Pinellia ternata, Rhizoma Chuanxiong, Atractylodes macrocephala Koidz and Gastrodia elata. 121 active components such as daucosterol, glycyrrhizin, gastrodin, β-sitosterol and gastrodin were obtained, which can act on 203 VM-related protein targets such as STAT3, SRC, MAPK3 and PIK3CA. KEGG enrichment analysis showed that there were 267 signal pathways such as MAPK, PI3K-Akt and cAMP signal pathways, which were involved in the regulation of inflammatory reaction, energy metabolism and signal transduction. Molecular docking verification shows that the active components of the core traditional Chinese medicine has good binding to the key target proteins. Based on data mining and network pharmacology research, it is found that licorice, Pinellia ternata, Ligusticum chuanxiong, Atractylodes macrocephala and Gastrodia elata, which is the modified prescription of Banxia Ma Baizhu decoction, is the core traditional Chinese medicine in the treatment of VM. The key components of its core drugs may play a synergistic role in the treatment of VM by regulating MAPK, PI3K-Akt, cAMP and other signal pathways. [ABSTRACT FROM AUTHOR]