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Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The integrated thermal protection system (ITPS) needs to meet both load-bearing and heat-insulating requirements. In terms of the ITPS with a corrugated sandwich structure, this requires the connection structure of the ITPS to have high mechanical properties with low thermal conductivity. However, the re-entry environment is severe, how to reasonably design the connection structure is key to improve the performances of the ITPS. To solve this problem, 2 extreme load conditions corresponding to the maximum aerodynamic heat load and the maximum aerodynamic pressure load during the reentry process were comprehensively considered, the objective function was constructed with the minimized strain energy and the net heat transfer rate, the mass was used as a constraint, and the topology optimization of the ITPS connection structure was carried out. Then, the configuration obtained through the topology optimization was reconstructed and the thermal mechanical coupling analysis was carried out. The results show that, the maximum displacement of the top panel, the temperature of the bottom panel and the mass of the optimized connection structure were reduced effectively compared with those of the initial corrugated sandwich configuration and the topology optimization configuration in single load cases in the literatures. Due to the reduction of material consumption and the increase of the structural complexity, the stress level of the connection structure increases, but it still meets the requirements of use. This means that, the topology optimization strategy considering multiple reentry load cases can effectively improve the stiffness and the insulation capacity of the ITPS and alleviate the thermal short-circuiting of the structure. With the development of additive manufacturing and other related technologies, the topology optimization method has broad prospects in the design of the connection structures for the ITPS and other thermal structures. [ABSTRACT FROM AUTHOR]

Copyright of Wool Textile Journal is the property of National Wool Textile Science & Technology Information Center and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Wool Textile Journal is the property of National Wool Textile Science & Technology Information Center and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the influence and the possible molecular mechanisms of oxymatrine (OM) on the proliferation, invasion, and metastasis of hepatocellular carcinoma. Methods Human hepatoma cell line HepG2 was randomly divided into the negative control group, low-dose, medium-dose, and high-dose OM groups. The negative control group was added with the cell culture fluid, besides,the OM groups were added with 1.0, 2.0, and 4.0 mg/mL OM and cell culture fluid. The cell proliferation was measured by MTT method and the inhibition rate of cell proliferation was calculated. The invasion and migration of cells in each group were detected by Transwell chamber assay. The expression of E-cadherin and CD44 mRNA in the OM groups was detected by real-time PGR, and Western blotting was used to detect the protein expression of E-cadherin and CD44. Results The cell proliferation inhibition rate of the high-dose OM group was higher than that of the medium-dose and low-dose OM groups, the medium-dose group was higher than that of the low-dose OM group, the number of transmembrane cells in the OM groups was less than that in the negative control group (all P < 0. 05) , the high-dose OM group was less than that in the medium-dose and low-dose OM groups, and the medium-dose group was less than the low-dose group (all P <0. 05). The mRNA and protein levels of E-cadherin in the OM groups increased but the mRNA and protein levels of CD44 decreased (all P <0. 05). Conclusion OM could inhibit the proliferation, invasion and migration of HepG2 cells in vitro, and its mechanism may be related to the up-regulation of E-cadherin and down-regulation of CD44 expression. [ABSTRACT FROM AUTHOR]

Copyright of China Pulp & Paper is the property of China Pulp & Paper Magazines Publisher and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)