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随着人口老龄化，长期接受抗血小板治疗的患者在神经外科手术治疗人群中的比例不断增加。抗血小板药物导致的潜在血小板功能低下会影响术中止血效果，并增加术中大出血和术后出血并发症风险。因此，如何在术前快速准确地评估血小板功能，对于全面评估患者止血功能具有重要意义。本文通过总结相关文献，结合血小板功能检测在神经外科的使用现状，分析目前常用血小板功能检测方法的优缺点，介绍改善血小板功能的相关疗法，以期提高神经外科医师对血小板功能的认识。 Abstract: With the aging of the population, the proportion of patients receiving long-term antiplatelet therapy among those undergoing surgical treatment is increasing. Potential platelet hypofunction caused by antiplatelet drugs can affect intraoperative hemostasis and increase the risks of massive intraoperative hemorrhage and postoperative bleeding complications. Therefore, a quick and accurate assessment of platelet function before surgery is of great significance in comprehensively evaluating a patient’s hemostatic function. Based on the summary of relevant literature and the current status of the application of platelet function tests in neurosurgery, this paper analyzed the advantages and disadvantages of the currently commonly used platelet function tests, and introduced relevant therapies to improve platelet function, with the aim of improving the understanding of platelet function among neurosurgeons.

目的 探讨卒中患者足底压力特点及其与躯干、平衡和运动功能的相关性。 方法 前瞻性纳入2021年6月—2022年11月首都医科大学附属北京天坛医院康复医学科收治的卒中患者。入院时采用躯干损伤量表（trunk impairment scale，TIS）、Berg平衡量表（Berg balance scale，BBS）、Fugl-Meyer运动量表下肢部分（Fugl-Meyer assessment lower extremity，FMA-LE）分别评定患者的躯干功能、平衡功能和运动功能。对双侧下肢进行睁眼和闭眼状态下的足底压力评估，比较患者健侧和患侧下肢睁眼和闭眼状态下的足底压力特点[负重、包络椭圆面积、压力中心（center of pressure，COP）路径长度和COP运动平均速度]，并对TIS、BBS和FMA-LE与双侧下肢睁眼状态下的足底压力指标进行相关性分析。 结果 共纳入45例患者，男性35例（77.8%）。健侧与患侧足底压力特征比较显示，健侧下肢的整体负重在睁眼（58.6%±11.1% vs. 41.4%±11.1%，P＜0.001）和闭眼（59.0%±11.8% vs. 40.9%±11.8%，P＜0.001）状态下均高于患侧下肢整体负重。睁、闭眼状态下足底压力特征比较显示，闭眼状态时的包络椭圆面积[（408.1±172.1）mm2 vs.（241.9±143.1）mm2，P＜0.001]大于睁眼状态、COP路径长度[（227.8±110.4）mm vs.（130.7±62.4）mm，P＜0.001]长于睁眼状态，且COP运动平均速度[（23.5±11.3）mm/s vs.（13.7±6.4）mm/s，P＜0.001）]高于睁眼状态；睁眼状态下，健侧前足负重（41.7%±12.8% vs. 38.2%±12.0%，P＝0.015）、患侧前足负重（39.0%±12.5% vs. 36.5%±12.1%， P＝0.020）高于闭眼状态，健侧后足负重（58.3%±12.8% vs. 61.7%±12.1%，P＝0.015）、患侧后足负重（60.7%±12.8% vs. 63.4%±12.1%，P＝0.018）低于闭眼状态，上述差异均有统计学意义。相关性分析显示，TIS、BBS和FMA-LE与睁眼状态下的包络椭圆面积（r＝－0.472，P＝0.001；r＝－0.537，P＜0.001；r＝－0.485，P＝0.001）、COP路径长度（r＝－0.427，P＝0.003；r＝－0.561，P＜0.001；r＝－0.424， P＝0.004）、COP运动平均速度（r＝－0.436，P＝0.003；r＝－0.563，P＜0.001；r＝－0.425，P＝0.004）及健侧下肢整体负重（r＝－0.326，P＝0.029；r＝－0.446，P＝0.002；r＝－0.551，P＜0.001）呈负相关，而与患侧下肢整体负重（r＝0.326，P＝0.029；r＝0.446，P＝0.002；r＝0.551，P＜0.001）呈正相关。 结论 卒中患者下肢负重偏向健侧；在去除视觉的情况下，患者静态站立的平衡功能下降；TIS、BBS和FMA-LE与安静站立时身体摇摆的程度及健侧下肢整体负重呈负相关，而与患侧下肢整体负重呈正相关。 Abstract: Objective To explore the characteristics of plantar pressure in stroke patients and its correlation with trunk, balance, and motor function. Methods The study prospectively included stroke patients admitted to the Department of Rehabilitation Medicine, Beijing Tiantan Hospital, Capital Medical University from June 2021 to November 2022. Upon admission, trunk function was assessed by the trunk impairment scale (TIS), balance function was assessed by the Berg balance scale (BBS), and lower extremity motor function was assessed by the Fugl-Meyer assessment lower extremity (FMA-LE) . Plantar pressure assessment was performed on both lower limbs in the eyes open and eyes closed states, and the plantar pressure characteristics of the unaffected and affected limbs were compared [weight-bearing, enveloping ellipse area, center of pressure (COP) path length, and COP mean velocity]. Correlation analysis was performed to assess the relationship between TIS, BBS, FMA-LE, and plantar pressure indices in the eyes open state of both lower limbs. Results A total of 45 stroke patients were included, with 35 males (77.8%). When comparing the plantar pressure characteristics between the unaffected and affected sides, the overall weight-bearing of the unaffected lower limb was higher than that of the affected lower limb in both open-eyed (58.6%±11.1% vs. 41.4%±11.1%, P

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Myocardial infarction is the most common cause of heart failure, and myocardial remodeling can occur after infarction, thus contributing to the progression of heart failure. The occurrence of post-infarction ventricular remodeling is closely related to m6 A methylation. m6 A methylation is a reversible and highly dynamic process. This process is mainly mediated by m6 A methylation positive and negative regulatory enzymes and is involved in the occurrence of post-infarction myocardial remodeling through mechanisms such as cellular autophagy. This article mainly reviews relevant literature in recent years. Firstly, a brief introduction is given to m6 A methylation, followed by an introduction to the role of m6 A methylase in regulating myocardial remodeling. Finally, a summary analysis is conducted on the mechanism of m6 A methylation in regulating myocardial remodeling from the perspectives of autophagy, inflammation, cell apoptosis, calcium ion homeostasis, extracellular matrix remodeling, and ferroptosis. The feasibility of using m6 A methylation serological detection as a diagnostic tool for myocardial remodeling after myocardial infarction is discussed, in order to provide reference for related research. [ABSTRACT FROM AUTHOR]

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Zinc oxide (ZnO) nano rods modified with gold (Au) nanoparticles were prepared by magnetron sputtering and hyd rot he rm al method, and characterized by field emission scanning electron microscope, transmission electron microscope, X-ray diffractometer and fluorescence spectrometer at different sputtering powers. The experimental results show that the ZnO nano rods at different sputtering powers are hexagonal wurtzite structure, grow along the crystal surface (002), and have high crystallinity. The UV excitation intensity of modified ZnO nano rods can be effectively enhanced by attaching Au nanoparticles to the surface. When the RF sputtering power is 80 W, ZnO nano rods show the best UV detection performance. Compared with unmodified ZnO nano rods, Au nanoparticles can inhibit the persistent photoconductivity (PPC) effect of ZnO nano rod s, and the response/recovery time of UV detection is reduced by 6.05 s and 4,54 s, respectively. The photodark current ratio is increased from 9.31 to 32.40, and the photo responsiveness is up to 1.94 A / W, which significantly enhances the UV detection capability of ZnO nano rods. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Engineering Geology / Gongcheng Dizhi Xuebao is the property of Journal of Engineering Geology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Autophagy is an important mechanism to maintain cellular function and metabolism, whereas abnormal autophagy can cause the advent and worsening of various diseases. N6-Methyladenosine（ m6A） RNA methylation is a reversible RNA modification, which is regulated by m6A methyltransferase, m6A demethylase and m6A-binding protein. Studies have shown that autophagy-related genes promote or attenuate autophagy level dependent on the regulation of m6A, and then participate in the process of diseases. This paper reviews the progress of m6A modification regulatory enzymes and their binding proteins in regulating cell autophagy to provide reference for future researches. [ABSTRACT FROM AUTHOR]

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Objective To investigate the clinical effect and safety of zoned low negative pressure liposuction combined with low energy bipolar radiofrequency and granular fat filling in mid-lower facial rejuvenation. Methods From October 2019 to April 2023, 32 patients (64 sides) with nasolabial depression with mid-lower facial fat accumulation and skin relaxation were retrospectively analyzed. The patients were followed up for 6 months after receiving bucaal low negative pressure liposuction combined with low energy bipolar radio frequency, nasolabial groove and lateral buccal depression granule fat filling treatment. The postoperative effect was evaluated by doctors and patients respectively, and the postoperative complications were counted. Results Among the 32 patients, the mean body mass index was (22.2±1.6) kg/m2, the mean fat extracted per zone was (3.6±2.4) ml, and the mean radiofrequency energy per zone was (1.6±0.5) kJ. After 6 months of follow-up, the patient's facial contour was smooth, skin elasticity was enhanced, and wrinkles were reduced. The average score on the 6-point grading scale (GGS) was decreased from (3.5±0.7) to (1.4±0.8) (P<0.05), the average facial laxity rating scale (FLR) score decreased from (5.3±0.6) points to (2.4±0.5) points (P<0.05), the self-rated satisfaction rate of patients was 90.6%. Postoperative Ⅰ degree skin scald occurred in 1 case, and oral Angle was slightly skewed in 2 cases in the early stage after surgery. The symptoms disappeared completely after 3 to 12 weeks of conservative treatment, and no complications occurred in the remaining patients. Conclusion The low negative pressure liposuction combined with low energy bipolar radiofrequency and particle fat filling can effectively improve the fat accumulation in the cheek, the aging of the "law line" in the nasolabial groove and the loose sag in the mid-lower face, which is a safe and reliable treatment method worthy of promotion. [ABSTRACT FROM AUTHOR]

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[Objective] The paper was conducted to study the effects of grazing and house feeding modes on meat quality and rumen microbiota of Tan sheep. [Method] Thirty-two male lambs ofYanchi Tan sheep with body condition close to[ (20.20 ±2.10) kg]were randomly divided into two groups (group C with total mixed diet) and grazing group (group G with grazing grassland), with 16 lambs in each group. At the same time, fresh rumen fluid was collected for high-throughput sequencing. The effects of grazing and house feeding on rumen microbial diversity and microflora structure of Tanyang sheep were analyzed. The pre-test lasted for 7 days and the test lasted for 80 days. [Result] The intramuscular fat, cooked meat percentage, pH (45 minutes), muscle color L and meat color b of longissimus dorsum of housed Tan sheep were significantly higher than those of grazed Tan sheep (P<0.05), while the pH (24 hours) and meat color a of grazed mutton were significantly higher than those of grazed Tan sheep (P<0.05) . Rumen fermentation parameters analysis showed that rumen pH, isobutyric acid, isovaleric acid and acetic acid/propionic acid of grazing Tan sheep were significantly higher than those of housed Tan sheep (P<0.05), but there were no significant differences in ammonia nitrogen, acetic acid, propionic acid, butyric acid and valeric acid between the two groups (P > 0.05). A total of 2106 OTUs were detected in the two groups, including 1869 and 1445 in the grazing group and the house feeding group, and 661 and 237 unique OTUs, accounting for 31. 38% and 11. 25% of the total OTUs, respectively. The number of species, Shannon index, Chaol index and ACE index observed in rumen microflora of grazing group were significantly higher than those of feeding group (P<0.05), while Simpson index of the two groups had no significant difference (P > 0.05) . The dominant bacteria in the rumen of the two groups were mainly Bacteroidetes, Firmicutesand and Proteobacteria, The relative abundance of Bacteroides in fattening Tan sheep samples was 81. 38%, higher than that in grazing group 52. 96% (P<0.05), while the relative abundance of Firmiculte in fattening group was 15. 88 %, lower than that in grazing group 37. 42 % (P<0.05) . The relative abundance of Proteobacteria in the feeding-house group was 1. 14%, which was slightly lower than that in the grazing group 5. 56% (P<0.05). At the genus level, The dominant genera were mainly unidentified Prevocidae (unidentified_Prevotellaceae), unidentified Bacteroides (unidentified_Bacteroidales), and unidentified Rumen (unidentified_Ruminococcaceae), the proportion of unidentified Prevotella was the highest, and the relative abundance of grazing group was 14. 74%, which was higher than that of fattening group 4. 35 % (P<0.05). The relative abundance of unidentified bacteroides in the grazing group was 3. 63%, which was slightly higher than that in the house feeding group 3. 32% (P > 0.05). The relative abundance of unidentified rumen bacteria in the grazing group was 6. 49%, which was higher than that in the house feeding group 2. 11 % (P<0.05). [ Conclusion] Feeding style can affect meat quality and rumen environment of Tan sheep, in which house feeding is beneficial to fat deposition and improve lamb tenderness, while grazing can improve rumen microbiota diversity and rumen health. [ABSTRACT FROM AUTHOR]

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In order to quickly diagnose the leakage of heating pipe network and improve its operation safety, a test apparatus for leakage detection and localization of heating pipe was built, and the acceleration sensors were used to measure the acoustic waves, the influence of different operation pressure, temperature, leakage aperture and leakage point location on leakage acoustic wave characteristics and leakage localization of heating pipeline were studied. The results indicate that when there is no leakage in heating pipe, the background noise energy is concentrated in the range of 0 ~ 1 000 Hz, after leakage occurs, the acoustic energy due to leaking will be concentrated in the range of 1 200 ~ 2 400 Hz and 3 200 ~ 4 000 Hz. With the increase of pressure and leakage aperture, the amplitude of leakage acoustic signal increases, the signal energy increases, the proportion of high frequency band energy increases, and the leakage localization becomes accurate. However, with the temperature increase, the amplitude of leakage acoustic signal decreases, the signal energy decreases, the proportion of low frequency band energy increases, and the leakage localization gets worse, the relative position of leakage point has little influence on the leakage localization accuracy, the approach by bandpass filtering could significantly improve the accuracy. [ABSTRACT FROM AUTHOR]

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