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Copyright of Journal of Chongqing University of Technology (Natural Science) is the property of Chongqing University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Nutritional Sciences Journal is the property of Nutrition Society of Taiwan and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: Platelet-rich fibrin not only exhibits anti-infective and anti-inflammatory properties, but also can promote tissue healing. It consists of various cytokines that can promote bone marrow mesenchymal stem cells (BMSCs) to differentiate into chondrocytes. OBJECTIVE: To explore the effect of platelet-rich fibrin on the repair of cartilage defect of old traumatic knee arthritis in weight-bearing region of rabbits. METHODS: Twenty-seven 6-month-old New Zealand rabbits provided by Experimental Animal Center, Soochow University, China were selected. Rabbit models of old traumatic knee arthritis cartilage defect in weight-bearing region (a depth of 3.0-4.0 mm, a diameter of 4 mm) were established by Hulth method. At 3 weeks, the granulation tissue was removed from the old defect via the original surgical incision, and the defect region was filled with the prepared filler. There were three groups, including platelet-rich fibrin, BMSCs and blank control groups. The joint was removed at 4, 8 and 12 weeks after repair for gross and histological observations. International Cartilage Repair Society scores and Wakitani’s scores were used to assess the repair outcomes. RESULTS AND CONCLUSION: Gross observation: at 4, 8, and 12 weeks after implantation, in the blank control group, abundant worn cartilage tissues, hyperplastic fibrous connective tissue and osteophyte, and articular cavity adhesion appeared. In the platelet-rich fibrin group, defect region was smooth, and the newly born tissue was similar to the surrounding normal tissue, which was better than that in the BMSCs group. Hematoxylin-eosin staining, Alysin blue staining, safranin-O staining, and type II collagen immunohistochemical staining showed that rabbit knee chondrocytes gradually increased, and chondrocytes showed type II collagen expression in the platelet-rich fibrin group. The degenerative chondrocytes at all layers were observed in the blank control group. There were few chondrocytes in the BMSCs group. International Cartilage Repair Society scores and Wakitani’s scores in the platelet-rich fibrinogen group were significantly superior to those in the blank control group (P < 0.01) and BMSCs group (P < 0.05). These results imply that platelet-rich fibrin can repair old cartilage defects in weight-bearing region caused by osteoarthritis, and its repairing ability is better than that of simple BMSCs. [ABSTRACT FROM AUTHOR]

BACKGROUND: Currently, there is no explicit evidence-based medicine evidence to prove the merits or demerits of absorbable materials in the treatment of fractures of the lateral humeral condyle in children. OBJECTIVE: To evaluate the clinical efficacies of open reduction with absorbable material versus open reduction with Kirschner wire fixation for lateral condylar fracture of the humerus in children. METHODS: WanFang, VIP, CNKI, CBMdisc, EMbase, PubMed were retrieved for controlled trials concerning open reduction with absorbable material versus open reduction with Kirschner wire fixation for treating lateral condylar fracture of the humerus in children. After data extraction and quality evaluations, RevMan 5.3 software was used for systematic review. Postoperative functional recovery of the elbow joint, average hospitalization expenses, adverse events, delayed union, postoperative infection, nerve injury and deformity of the elbow were compared in patients undergoing different treatments. RESULTS AND CONCLUSION: A total of seven articles, involving 449 children with lateral condylar fracture of the humerus, were included for this Meta-analysis. Children in test group received open reduction with absorbable material, while those in control group were subjected to open reduction with Kirschner wire fixation. For treating lateral condylar fracture of the humerus in children, no significant inter-group difference existed in the aspects of postoperative functional recovery of the elbow joint [odds ratio (OR)=0.72, 95% confidence interval (CI) (0.37, 1.41), P=0.34]; postoperative delayed union [OR=0.46, 95% CI (0.16, 1.30), P=0.14]; deformity of the elbow [OR=0.70, 95% CI (0.24, 2.10), P=0.53]. Less adverse events and postoperative infections were observed in the test group compared with the control group [OR=0.17, 95% CI (0.08, 0.38), P < 0.000 1; OR=0.09, 95% CI (0.02, 0.38), P=0.001]. However, up to now, we knew of no comparable data concerning average hospitalization expenses and indicators for nerve injury between the two groups. To conclude, compared with Kirschner wire fixation, open reduction with absorbable material can achieve similar effects on lateral condylar fractures of the humerus, but has better effects to prevent adverse events and postoperative infection. Further investigation on large-scale, double-blind, high-quality randomized controlled trials is warranted for confirming our results. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Eastern Liaoning University (Social Sciences) is the property of Department of Journal of Eastern Liaoning University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)