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Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

HepatoceIIuIar carcinoma (HCC) is the major histoIogicaI type of primary Iiver cancer (PLC), and the etioIogy is reIative cIear. Chronic infection of hepatitis B virus (HBV) pIays dominant roIes, and high exposure to afIatoxins is an important co-factor. Qidong was one of the endemic area with high PLC incidence in ruraI China. The resuIts from a series of etioIogicaI intervention studies on PLC in this area indicated that 1) the protective efficacy of neonataI HBV vaccination against PLC deveIopment under the age of 30 was 84% (95% CI 23%-97%); 2) the reIative risk of Iiver cancer incidence decreased at Ieast 4 foIds in young aduIts aged <35 years with reducing afIatoxin exposures and cIeaning drinking water. The prevention of HBV infection and the suppIies of cIean water and safe food with Iimited afIatoxins demonstrated as an effective primary prevention modeI of Iiver cancer in ruraI China. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi is the property of Journal of Clinical Hepatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi is the property of Journal of Clinical Hepatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the HBsAg seroprevalence in the young generation in Qidong of Jiangsu Province, China. Methods A total of 15 534 students for college entrance examination from 2006 to 2014 were randomly selected from three secondary schools in Qidong as student group. Some of them had hepatitis B vaccination at birth. A total of 1208 adults who had their routine checkups in our hospital from 2007 to 2013 were selected as adult group. It was confirmed that all of them did not have hepatitis B vaccination at birth. Serum HBsAg levels of the two groups were measured using enzyme-linked immunosorbent assay and the seroprevalence was analyzed. Comparison of data between the two groups was made by chi-square test. Results In the 9 years from 2007 to 2013, the seroprevalence rates of HBsAg in the student group were 4.2%(75/1794), 4.3%(77/1797), 4.4%(82/1858), 4.3%(82/1903), 3.4%(56/1627), 2.6%(46/1768), 1.6%(29/1778), 1.6%(27/1642), and 1.8%(24/1367), respectively. The mean HBsAg seroprevalence of the student group was 3.2%(498/15534), significantly lower compared with 7.1% (86/1208) of the adult group (χ2= 59.986, P＜0.001). In both of the student group and the adult group, the males had a significantly higher HBsAg seroprevalence than the females (χ2=10.521, P=0.001; χ2=8.452, P=0.004) and the values were 3.7%(266/7236) vs 2.8%(229/8298) and 8.8%(66/750) vs 4.4%(20/458), respectively. Among male subjects, the HBsAg seroprevalence of the adult group was 2.4 times that of the student group; among female subjects, the HBsAg seroprevalence of the adult group was 1.6 times that of the student group. Conclusion In the recent 9 years from 2006 to 2014, the HBsAg seroprevalence in students for college entrance examination declined continuously. The goal set by the World Health Organization Western Pacific Region in 2010 had been achieved ahead of the schedule that the HBsAg seroprevalence should be controlled below 2% in children aged less than 5. [ABSTRACT FROM AUTHOR]