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北京未来城学校教学楼的地上部分采用钢框架结构，并设置2道结构缝将造型奇特的教学楼分为3个部分。教学楼地下部分不设缝连为整体，采用钢筋混凝土框架结构。钢连廊跨度为33 m，采用2层通高桁架结构。钢连廊与两侧主体结构采用弱连接，通过对比3种支座方案，选用布置金属摩擦摆隔震支座+黏滞阻尼器的方案。对钢连廊与两侧主体结构整体模型进行动力弹塑性时程分析，连廊整体作为刚体随3层主楼楼面发生地震响应，隔震支座的隔震效果显著。此外，介绍了本项目中钢筋混凝土梁与钢骨混凝土柱连接节点及梁配筋的注意事项，为后续相关工程设计提供参考。

本研究旨在以改良式德懷術建構一套中學數學教學知能指標，作為評測數學教學知能之工具，以確保師資生教學品質及其專業知能發展的機制，提供相關單位在師資培育、甄選及證照制度時之參考。本研究首創改良式德懷術，依不同的性質目的，研究者可與專家群討論並預設準則，「達成共識」需經統計檢定，加強指標建立之有效性及精準度。本研究邀請德懷術專家成員共25人，他們均具有數學背景，包括九位大學教授、八位國中小校長、四位行政人員及四位現職教師。研究工具採用自編之「中學數學實習師資生能力指標之調查問卷」。本研究之重要結果有：一、建構之「中學數學實習師資生教學知能指標」包含四層面、七向度與34項指標，兼顧數學教學、教室經營、教學評量和教學態度層面，蘊含了十二年國民基本教育強調「有感」、「動手操作」、「引起學習動機與興趣」、「科技融入」的素養教學 理念。二、改良式德懷術兼具高效率與高準確率。可依領域爭議性設定目標值，並經統計檢定準確的判斷出專家群達共識的結果，例如本研究在第二回合中就有16項指標已達成共識，第三回合僅需請專家群判斷剩餘的指標。 1. Background The modern educational reform movement has continually promoted high teaching quality since the 1980s. In the education system of Taiwan, a reliable evaluation system for probationary teachers has been developed. First, since the approval of the Teachers Cultivation Law in Taiwan by legislators in 1994, both colleges and general universities have offered education programs for teaching mathematics. Second, during the teachers’ probationary period, both an experienced math teacher and a university professor play the role of supervisors and mentors. However, not all experienced school teachers have mentor training experience. Furthermore, the opinions about the criteria for assessing probationary teachers may differ between school teachers and university professors. Third, after 2002, the probationary period for new teachers in secondary schools in Taiwan was changed from 1 year (two semesters) to half a year (one semester). Therefore, identifying ways to make the half year of apprenticeship as effective as a 1-year apprenticeship is crucial. Fourth, the vision of the 12-year compulsory education is “Making All Students More Successful,” which emphasizes that students are active learners. Core competencies refer to the knowledge, ability, and attitude that an individual must possess to adapt to daily life situations and face future challenges (Ministry of Education, 2014). Based on the aforementioned concerns, establishing an appropriate quality assessment system that not only ensures that probationary teachers’ grades are objective and consistent but also maintains the quality of all future mathematics teachers is essential. This is the rationale for developing a set of indicators to serve as a fair standard for evaluating each probationary math teacher in secondary schools. Accordingly, this study applied a modified Delphi method to establish a set of feasible and practical indicators for the evaluation of the teaching competence of probationary mathematics teachers in Taiwan. Moreover, the proposed modified Delphi method was tested and verified. 2. Review of Literature on the Delphi Method The Delphi technique is a process of collecting and refining the opinions of experts in order to obtain a consensus on a particular topic of present or future action, especially topics for which there is little knowledge of certainty (Dalkey & Helmer, 1963; Fischer, 1978; Hardy et al., 2004; Powell, 2003). The Delphi method has been widely applied in education, business, industry, heath care, and many other fields worldwide. Although the Delphi method is notable for its democratic, structured approach and participant anonymity, little is known about the minimum level of agreement required to achieve a consensus, thus leaving the technique open to criticism (Goodman, 1987; Keeney et al., 2001; Osborne et al., 2003; Powell, 2003; Reid, 1988; Rowe et al., 1991; Williams & Webb, 1994). Concerns regarding this technique include how to achieve a consensus for an indicator and what is the minimum level of agreement to reach a consensus in a given situation. 3. Methods Step 1: Set the target values Because the expert panel in this study comprised 25 experts and a topic from the education field was selected, we used a higher criterion to reach a consensus. After discussion with other researchers, we decided to use a 5-point Likert scale and set the following target values: (1) the percentage of respondents choosing “5” should be greater than 65% without no one choosing “1”or “2”; (2) For mean, if 17 experts choose “5” and 8 experts choose “3”, set the mean as 4.36. (3) For standard deviation, if 17 experts choose “5”, 4 experts choose “4”, and the other 4 experts choose “3”, set the SD as 0.77. Step 2: Compare the observation results with the target values After determining the target values, means, and standard deviations, we perform the statistical hypothesis process to reach a consensus as follows. (1) Testing of the Standard Deviation 0 H : .77 σ ≥ vs. 1 H : .77 σ < First, we compare the sample standard deviation for each indicator with the target value through statistical hypothesis testing. If the null hypothesis is not rejected, it indicates that the expert panel’s opinions are not consistent, and that the indicators must be modified and experts must be consulted again for further analysis until a consensus is reached. Otherwise, if the null hypothesis is rejected, it indicates that the experts have reached a consensus, and that further input from the expert panel is not needed. We then proceed with testing the mean of the indicator. (2) Testing of the Mean 0 H : 4.36 µ ≤ vs. 1 H : 4.36 µ > After the standard deviation is tested, the mean of the indicator is assessed to validate its’ importance. If the null hypothesis is rejected, it indicates that a consensus has been reached for the expert panel’s opinions, and that further input from the expert panel is not needed. Otherwise, if the null hypothesis is not rejected, the indicators must be modified, and that the experts must be consulted again for further analysis until a consensus is reached. If the experts are consulted again, the standard deviation testing must also be performed again. To sum up, this modified method is more stringent than the traditional Delphi method and more efficiently identifies final indicators because some ideal indicators may be preserved only through one or two rounds. 4. Results This study found that a set of 4 aspects, 7 vectors, and 34 indicators are essential components of teaching competences of middle school student teachers. 5. Conclusion (1) A set of indicators were established in this study by considering aspects such as mathematics teaching, class management, evaluation, and attitude. These indicators emphasized “perceptible,” “hands-on learning,” “motivation,” and “technology integration,” which corresponded to the core competencies of the 12-year compulsory education. (2) The proposed modified Delphi method can be used to effectively and accurately judge the expert panel’s consensus. For example, a consensus was reached for the opinions of the expert panel regarding 16 indicators in round 2; therefore, the experts only had to judge the last indicators in round 3.

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格构式输电铁塔主要以单角钢作为主材。大量输电铁塔倒塌是由于铁塔的塔腿主材部位发生失稳。因此，对存在安全隐患的输电铁塔主材进行加固补强尤为重要。以单根主材为研究对象，应用十字形夹具式主材加固方法，建立了主材加固前、后的有限元模型，分析了夹具数量、夹具间距、副主材长度、螺栓预紧力和摩擦系数等参数对主材极限承载力的影响规律。结果表明：随着夹具间距的减小和夹具数量的增多，主材极限承载力先逐渐增大后趋于平缓；副主材长度过短起不到加固的作用，建议副主材长度不小于主材长度的1/2。

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Objective：To explore whether atorvastatin (Ator) can induce ferroptosis in pancreatic β⁃ cell line MIN6 cells and its possible mechanism. Methods：MIN6 cells were divided into control group, Ator group, Ator+apoptosis inhibitor (Z-VAD-FMK) group, Ator+necrostatin-1 (Nec-1) group and Ator+ferrostatin-1 (Fer-1) group. Cell viability was detected by cell counting kit-8 (CCK-8) method. The ultrastructure of cells was observed by transmission electron microscopy. The levels of reactive oxygen species (ROS) and Fe2+were observed by fluorescence microscopy. The contents of malondialdehyde (MDA) and glutathione (GSH) were detected by enzyme⁃linked immunosorbent assay (ELISA) method. Real⁃time quantitative PCR was used to detect the mRNA levels of caspase-3, receptor-interacting protein kinase 3 (Ripk3), acyl-CoA synthetase long⁃chain family member 4 (Acsl4), prostaglandin endoperoxidase synthase 2 (Ptgs2) and glutathione peroxidase 4 (Gpx4) . Western blot was used to detect the proteins levels of 4-hydroxynonenal (4-HNE) and GPX4. Results：Compared with the Ator group, cell viability of MIN6 was higher in Ator+Z-VAD-FMK group and Ator+ Fer -1 group (P < 0.01) . MIN6 cells, which were treated with Ator, exhibited the characteristic morphologic features associated with apoptosis, ferroptosis and autophagy under transmission electron microscopy. Compared with the control group, the levels of the intracellular Fe2+, MDA and ROS in the Ator group were increased and GSH was decreased. The mRNA relative expression levels of caspase⁃3, Acsl4 and Ptgs2 were increased, as well as the protein relative expression level of 4⁃HNE (all P < 0.05). The mRNA and protein relative expression levels of GPX4 were decreased (P < 0.05). Compared with the Ator group, the levels of the intracellular Fe2+, MDA and ROS in the Ator+Fer-1 group were decreased and GSH was increased. The mRNA relative expression level of Acsl4 was decreased and Gpx4 was increased (all P < 0.05). The protein relative expression levels of 4⁃HNE was decreased and GPX4 was increased, though the changes were not statistically significant. Conclusion：Atorvastatin may induce ferroptosis in MIN6 cells by down-regulating GPX4 expression through inhibiting mevalonate pathway. [ABSTRACT FROM AUTHOR]

Copyright of Lubrication Engineering (0254-0150) is the property of Editorial Office of LUBRICATION ENGINEERING and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Objective To explore the effect of continuous follow-up nutrition management in specialized outpatient clinics on nutritional index and hope level of nasopharyngeal carcinoma radiotherapy patients. Methods From October, 2021 to December, 2022, a total of 150 patients with nasopharyngeal carcinoma who received radiotherapy in Henan Provincial People's Hospital were divided into two groups; the control group (routine nursing) and the observation group (continuous follow-up nutrition management in specialized outpatient clinics+routine nursing) by random number table method, and the intervention lasted for two months. The related indicators of the two groups were compared. Results Compared with the satisfaction rate [76. 00%(57/75)] and the total excellent and good rate of compliance [77. 33% (58/75)] of the control group. after intervention, the satisfaction rate [93. 33%(70/75)] and the total excellent and good rate of compliance [94. 67%(71/75)] of the observation group were higher(X²=8. 679. 9. 358,P<0. 05): Compared with before intervention. all the scores of hope level(maintaining close relationship with others, taking positive actions, facing reality and future positivity) of the two groups were increased after intervention and compared between the groups, the observation group [(12. 25±1. 23),(12. 37±1. 56),(13. 48±1. 35) points] was higher than the control group (t=7. 338. 7. 919. 9. 885, P<0. 05); Compared with before intervention, serum ALB. PA and HB levels in both groups were decreased(after intervention), but compared between the groups, the observation group(40. 58±4. 34)g/L, (249,55±16. 57)mg/L,(123. 78±14. 56)g/L] was higher than the control group(11. 434. 14. 150. 7. 513. P<0. 05). Conclusion The application of continuous follow-up nutrition management in specialized outpatient clinics for nasopharyngeal carcinoma radiotherapy patients can help to re- duce the influence of radiotherapy on the nutritional status of patients improve the hope level and compliance, and then improve the prognosis and satisfaction. [ABSTRACT FROM AUTHOR]

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Urban agglomerations are the main spatial carriers of national and regional urbanization development. The study of their spatial association networks is of great significance for optimizing the allocation of urban resources, promoting the process of regional integration, and facilitating the high-quality development of urban agglomerations. The Yangtze River Delta urban agglomeration (YRDUA) is one of the most economically active regions in China. Its spatial association network structure was the main feature of economic and social development in China's "14th Five-Year Plan." Based on the perspective of flow spaces in terms of both the city and township scales, multi-source data were used in this study and included online car-hailing origin-destination travel data, combined with complex network models and a quadratic assignment procedure, to analyze the structural characteristics and driving mechanism of the spatial association network of the YRDUA. Results show that: 1) spatial association network based on online car-hailing flow in the YRDUA has spatial dependence and hierarchical characteristics, and intensities of network association are mostly coupled with levels of economic development; 2) spatial association network in the YRDUA displays spatial spillover effects, leading to an overall pattern of high equilibrium in southern development and strong single-point development capacity in the north; 3) the structural features of spatial association network in the YRDUA differ between townships and urban scales, with some high-level townships in certain transportation networks failing to exert their driving role at the urban level; and 4) economic development status, population vitality, the level of urban construction, and administrative division ownership and geographical location differences between townships have significant impacts on the spatial association network structure in terms of the township scale. The differences in administrative divisions are most important. Online car-hailing travel data were used in this study to effectively supplement the links between township streets within and between cities. This data also revealed intercity links. Thus, the development characteristics of spatial units on different scales were reflected, and research and social management needs were satisfied on a fine scale. In addition, by introducing spatial big data and analyzing the influence mechanism from various aspects, such as socioeconomics, the driving factors of the spatial network of urban agglomerations were systematically identified at the small-scale level, which will help with more reasonable planning within the city and play a role in the development of urban agglomerations by enhancing the attractiveness of individual cities. This study expands the research perspectives on the cooperative development of urban agglomerations on different scales, providing theoretical references and practical support for the promotion of the coordinated development of urban agglomerations as a whole. [ABSTRACT FROM AUTHOR]

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Objective To explore the clinical manifestations, genetic characteristics, and treatment of progeria. Methods Clinical data of 11 progeria patients treated at Peking Union Medical College Hospital from August 2012 to June 2023 were collected, and clinical and genetic features were summarized, including pubertal development, glucose metabolism, lipid metabolism, previous cardiovascular lesions (atherosclerosis, cardiac arrhythmia, valvular disease, and cardiomyopathy) and treatment. Early clinical manifestations and gene mutation characteristics, laboratory tests, pubertal development, and assessment of glucose and lipid metabolism and cardiovascular disease in patients with progeria were analyzed. Results Of the 11 patients, 7 werefemale and 4 were male, with ages ranging from 9 to 37 years. One case had adult onset, while the rest had onset at birth or during childhood and adolescence. Majority of the patients had varying degrees of delayed puberty, and more than half had abnormalities in glucose and lipid metabolism, particularly insulin resistance, and markedly low high‑density lipoprotein‑cholesterol levels. Cardiovascular abnormalities were common, with 3 patients experiencing extensive myocardial damage leading to heart failure, 3 patients presenting with arrhythmia, and 2 patients showing atherosclerosis. Of the 5 patients who underwent comprehensive genetic testing, 4 had Lamin A/C (LMNA) gene mutations at non‑typical mutation sites, namely c.139G>T, c.1444C>A, c.398G>T, and c.1045C>T. The c.1444C>A mutation has not been reported before, and 1 patient had a WRN gene c.3913C>T mutation. Treatment focused primarily on symptomatic interventions for abnormalities in glucose and lipid metabolism and cardiovascular diseases. Conclusions Progeria patients present with a variety of clinical manifestations. Adolescents and adults with progeria should pay attention to the assessment of puberty development, glucose and lipid metabolism, and cardiovascular abnormalities, and early intervention with targeted treatments is recommended. [ABSTRACT FROM AUTHOR]

From the perspective of residents, this article interprets the construction of community and family elderly care facilities in urban areas of China, combines residents’needs to understand the shortcomings in the construction of elderly care facilities in urban areas, and explores corresponding optimization measures. The study conducted a questionnaire survey on urban community families in Jiangsu Province, to obtain the needs of residents for medical and elderly care integration. At present, there is a lack of awareness of aging - friendly transformation within urban households in China, and the effect of the construction of standardized elderly care communities is minimal, and the infrastructure configuration for the elderly population is insufficient. Both family elderly care and community home - based elderly care models occupy a mainstream position among different age groups, and residents’ needs for ageing - friendly home modifications are concentrated on healthcare, with the hope that the community where they are located will soon establish a comprehensive and standardized elderly care community. Based on these, we will explore strategies for constructing and renovating integrated medical and elderly care facilities. [ABSTRACT FROM AUTHOR]

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In recent years, the mechanisms of repeated ultraviolet light (UV) radiation-induced spatial and temporal changes in the immune microenvironment and the imbalance are the hot research topic in the fields of skin, immunity, tumor and aging. Chronic UV radiation (UVR) can induce cellular phenotypic and functional changes in the skin microenvironment, and directly and indirectly alter the skin immune microenvironment. UVR induces immunosuppression, including activation of regulatory T cells and alterations in the number and function of antigen-presenting cells. The interactions among B cells, T cells, Langerhans cells and mast cells play an important role in UVR-induced immunosuppression. In addition, the effects of UVR on T cell co-inhibitory and co-stimulatory signals have been increasingly appreciated. In this paper, we review the recent progress in the imbalance of the immune microenvironment in the chronically photodamaged skin. [ABSTRACT FROM AUTHOR]