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Heavy ion beam（HIB）irradiation, with high mutagenesis rate, broad mutagenesis spectrum and stable mutant, has been widely used in the implementation of industrial microbial breeding. With the development of sequencing technology, a more comprehensive understanding of the biological information at multiple levels such as genome, transcriptome, proteome, and metabolome may be achieved via study on the mutagenesis effect of HIB. This paper summarizes the research progress of microbial breeding using HIB, combining highthroughput sequencing technology to explore the biological effects of heavy ion mutagenesis. On this basis, a new idea of using omics methods to study the mutagenesis effect of HIB was further discussed with aim to provide references and suggestions for the breeding technology. [ABSTRACT FROM AUTHOR]

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