【Objective】The present paper aimed to evaluate the epidemic status of common pathogens large-scale pig farms in Sichuan.【Method】In this study, 283 samples(pathological tissues, boar semen, miscarriage and stillbirth) were collected and detected by bacterial isolation and identification, RT-PCR, PCR. 【Result】The positive rates of CSFV, PRRSV, PRRSV NADC30-Like, PCV2, PRV, APP, PM and SS2 in the pathological tissues samples of 106 pigs were 7.55 %(8/106),40.57 %(43/106), 20.75 %(22/106),34.91 %(37/106),16.04 %(17/106),9.43 %(10/106),19.81 %(21/106) and 4.72 %(5/106), respectively. Among the percentage of multiply infections was 60.49 %(49/81). The pathogens infection of PRRSV or PCV2 not only emerges in throughout the year but also occurs frequently with other pathogens infection and bacterial infection are most common in summer. The positive rates of CSFV, PRRSV, PCV2 and PRV in 68 boar semen samples were 10.29 %(7/68), 30.88 %(21/68), 20.59 %(14/68) and 20.59 %(14/68), respectively. Among the 38 positive samples, the percentage of single infections was 52.63 %(20/38). The positive rates of CSFV, PRRSV, PCV2 and PRV in 63 miscarriage and stillbirth samples were 6.35 %(4/63),46.03 %(29/63),38.10 %(24/63) and 30.16 %(19/63), respectively. The most common infection type was PRRSV with other pathogens infection and PRRSV was more common in throughout the year and the percentage of multiply infections was 74.50 %(38/51). The infections of PEDV and PoRV are common in spring, autumn and winter. The positive rate of PEDV and PORV were 56.52 %(26/46) and 26.09 %(12/46) in intestinal mucosa and feces of 46 diarrhea pig samples.【Conclusion】The Prevention and control of PRRSV, PCV2, PRV and PEDV were still key point in the future, meanwhile, the multiple pathogen infection and new variants PRRSV NADC30-Like is also difficult to prevent from large-scale pig farms in Sichuan area. [ABSTRACT FROM AUTHOR]