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Objective To examine the joint effects of parent-child relationship and environmental sensitivity (ES) on adolescent mental health from the perspective of sensitivity X family conflict interaction. Methods In 2023, we investigated 7,010 adolescents from six junior high schools in Shaanxi Province, China. Self-reported questionnaires were used to assess parent-child relationship, ES, and adolescent mental health. ES was assessed by Highly Sensitive Child Scale (HSC) ; Patient Health Questionnaire-9 (PHQ-9), Strengths and Difficulties Questionnaire (SDQ), and Happiness index were used to measure depression, externalizing problems, and subjective well-being. Results ① Girls' ES scores were significantly higher than boys' (t=-7.504, P<0.01) . ② When predicting depression and externalizing problems, the main effects of parent-child relationship and ES in adolescents were significant (b=-0.263, 0.237, 0.332, P<0.001; b=0.201, 0.220, P<0.001), and the interaction between family conflicts and ES was significant (b=-0.072, P<0.05; b=0.092, P<0.05) . (3) Widaman's confirmatory and competitive approach results showed the significant interaction of sensitivity X family conflict with depression and externalizing problems, which were consistent with the differential susceptibility and diathesis-stress framework, respectively (BIC=2 170.98, 2 162.6) . Conclusion Adolescents with high environmental sensitivity suffer more from high family conflict and benefit more from low family conflicts. These sensitive adolescents can be described as having developmentally susceptibility rather than vulnerability. [ABSTRACT FROM AUTHOR]

Objective To investigate the effect of peripheral blood bile acids on the cognitive function of schizophrenia patients. Methods Targeted metabolomics was adopted to analyze the total level of primary and secondary serum bile acid metabolites collected from 23 schizophrenia patients and 23 health control individuals. The MATRICS Consensus Cognitive Battery(MCCB)was adopted to evaluate the subjects' cognitive function in five dimensions. Results We found that the schizophrenia patients had impaired cognitive functions in multiple dimensions including speed of processing, working memory, reasoning and problem solving, and visual learning. Compared with the health control group, serum levels of cholic acid(CA)and chenodeoxycholic acid(CDCA)were significantly lower in patients with schizophrenia, while serum level of glycocholic acid(GCA)was significantly higher, and the ratio of deoxycholic acid(DCA)to CA was higher(3.04 vs. 1.16). Speed of processing, working memory, reasoning and problem solving, and visual learning abilities were significantly negatively correlated with serum levels of multiple primary bile acids including taurocholic acid(TCA), GCA, glycochenodeoxycholic acid(GCDCA)and taurochenodeoxycholic acid(TCDCA), after adjustments of age, sex, and body mass index. Conclusion The bile acid profile of schizophrenia patients is obvious, and the decrease in neuroprotective bile acids(namely, CA and CDCA)and the up-regulation of cytotoxic bile acid(i.e., GCA)may impair the cognitive function of schizophrenia patients. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Xi'an Jiaotong University (Medical Sciences) is the property of Xian Jiaotong University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To explore the effect of childhood maltreatment on clinical symptoms and early efficacy of antipsychotics in patients with schizophrenia. Methods Totally 73 schizophrenic patients were divided into mild maltreatment group(n=42) and severe maltreatment group(n=31) according to the Child Trauma Questionnaire(CTQ). The Positive and Negative Symptom Scale(PANSS) and Clinical Global Impression(CGI) were measured and compared between the two groups at baseline and 3 weeks after antipsychotic treatment to analyze the correlation between child maltreatment experience and mental symptoms and the response to early treatment of antipsychotics. Results PANSS positive factor score(P=0.026) and cognitive deficit factor score (P=0.042) were significantly higher in severe abuse group than in mild abuse group. The positive factor was significantly positively correlated with emotional abuse factor in CTQ score(r=0.257, P=0.028), and the cognitive deficit factor was significantly positively correlated with emotional neglect factor(r=0.283, P=0.015). After antipsychotic treatment, the reduction rate of PANSS negative factor in severe abuse group was significantly lower than that in mild abuse group(P=0.035), and had the highest correlation with CTQ physical abuse factor(r=-0.302, P=0.011). Conclusion The severity of childhood maltreatment experienced by schizophrenic patients is more related to positive symptoms and cognitive deficits, and more childhood maltreatment experience will affect the improvement of negative symptoms by antipsychotics, suggesting a poor prognosis. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Xi'an Jiaotong University (Medical Sciences) is the property of Xian Jiaotong University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the relationship between sleep duration (SD) collected by polysomnography and ischemic stroke in community populations. Methods We recruited 2062 participants, including 724 males and 1338 females. The mean age of the all participants was 61.44 years. In this study, the subjects were divided into three groups according to SD: short SD (<6h), long SD (>8h), and normal SD (6-8h). Logistic regression was used to analyze the independent association between the three different sleep durations and the occurrence of ischemic stroke. Results ① The three groups differed significantly in gender, age, BMI, prevalence of diabetes and serum triglyceride levels (P<0.05). ② The incidence of ischemic stroke was significantly higher in short SD group than in long SD group and normal SD group (the incidence rates were 5.9%, 2.7% and 1.6%, respectively; P=0.044, P<0.001). ③ Univariate logistic regression analysis suggested that short SD was associated with the occurrence of ischemic stroke (OR=3.845, 95% CI: 1.789-8.266, P=0.001). After adjusting potential factors such as gender, age, marital status, alcohol consumption, hypertension, diabetes and triglycerides, multivariate logistic regression analysis showed that short SD was still an independent risk factor for ischemic stroke (OR=2.629, 95% CI: 1.033-6.693,P=0.043). Conclusion The incidence of ischemic stroke differs in people with different SD. Among them, the incidence of ischemic stroke is higher in people with short SD. [ABSTRACT FROM AUTHOR]

Objective To analyze brain white matter integrity of patients with schizophrenia in the first episode and recurrent episode so as to explore the pathogenesis of schizophrenia. Methods Demographic and clinical information was collected and magnetic resonance imaging was performed in 34 patients with first-episode schizophrenia, 33 patients with recurrent schizophrenia, and 50 healthy controls. The tract-based spatial statistics (TBSS) was used to evaluate the white matter integrity. Results Compared with the control group, both the schizophrenics in the first episode and recurrent episode showed decreased fractional anisotropy (FA) values in bilateral superior longitudinal tract, bilateral inferior frontal and occipital tracts, bilateral middle cerebellar peduncle, corpus callosum corpora and compressor, bilateral anterior and posterior radiating corona, and left superior radiating corona (P<0.05). Compared with those in recurrent episode, the FA values of the patients in the first episode decreased significantly in bilateral upper longitudinal tract, bilateral anterior radial crown, corpus callosum body part and compression part, but increased in left inferior frontal occipital tract and bilateral cerebellar middle foot (P<0.05). Conclusion The white matter of patients with schizophrenia in the first episode and recurrent episode shows extensive abnormalities, and the damage of white matter integrity is more serious in patients with first-episode schizophrenia. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Xi'an Jiaotong University (Medical Sciences) is the property of Xian Jiaotong University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Southwest China Journal of Agricultural Sciences is the property of Editorial Department of Southwest China Journal of Agricultural Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)