Search

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

幽门螺杆菌是一种革兰阴性杆菌，其参与代谢相关脂肪性肝病的发病。幽门螺杆菌可通过诱导慢性炎症 状态、改变脂质谱、调节激素分泌等引起胰岛素抵抗，间接引起代谢相关脂肪性肝病的发生。幽门螺杆菌还能改变 肠道菌群和肠道通透性，影响营养物质与毒素产物的吸收，进而参与代谢相关脂肪性肝病的发生和发展。此外，特 定基因型个体合并幽门螺杆菌感染时，幽门螺杆菌可通过激活促肝脏纤维化信号分子表达等机制参与代谢相关脂 肪性肝病的发病。然而，目前相关研究以横断面研究和回顾性研究为主，暂时不能明确幽门螺杆菌与代谢相关脂肪 性肝病的因果关系，且缺乏以肝活检作为诊断标准的研究。未来需要以动物实验及队列研究进一步证实两者的联 系及可能机制。 [ABSTRACT FROM AUTHOR]

小肠细菌过度生长（SIBO）是由小肠内细菌过多引起的伴有一系列胃肠道症状的临床综合征。SIBO的病 因较为复杂，与胃酸缺乏、肠动力障碍、小肠解剖改变、免疫抑制等保护性抗菌机制失效有关。同时，SIBO在肠易激 综合征、胰腺炎、炎症性肠病、肝病、肥胖和自闭症谱系障碍患者中均有较高的阳性率，说明这些疾病可能是SIBO的 危险因素。 [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the diagnostic values of pigment endoscopy combined with C-reactive protein (CRP and transferrin(TRF) in patients with early esophageal cancer in Qinghai district. Methods: June 2018 to March 2020, 250 cases of patients in Qinghai district who were selected for esophageal cancer screening in our hospital, all the cases were all given endoscopy, and plasma CRP and TRF were detected, and were also given to determine the diagnostic values. Results: The pathological diagnosis were 28 case were carcinoma in situ, 10 with cases were high-grade intraepithelial neoplasia, 12 cases were low-grade intraepithelial neoplasia, and 200 cases were chronic inflammation that there were 38 cases were early esophageal cancer. Pigment endoscopy showed 47 cases without staining, 95 cases with light staining, 108 cases with concentrated staining. The plasma CRP value of patients with early esophageal cancer were higher than that of patients with non-early esophageal cancer, the TRF value were lower (P<0.05). Pearson correlation analysis showed that pigment endoscopy without staining, CRP and TRF values were correlated to the early esophageal cancer in Qinghai district(P<0.05). The diagnostic sensitivity and specificity of pigment endoscopy combined with CRP and TRF in early esophageal cancer in Qinghai were 97.4 % and 100.0 %, respectively. Conclusion: The application of pigment endoscopy combined with CRP and TRF in the diagnosis of patients with early esophageal cancer in Qinghai have good sensitivity and specificity, they can effectively predict the occurrence of early esophageal cancer, and have certain guiding significance for early diagnosis and treatment of early esophageal cancer. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi is the property of Journal of Clinical Hepatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi is the property of Journal of Clinical Hepatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi is the property of Journal of Clinical Hepatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

ObjectiveTo investigate the clinical features of patients with recurrence after endoscopic retrograde cholangiopancreatography (ERCP) and cholecystolithotomy and related risk factors. MethodsA retrospective analysis was performed for the clinical data of patients with common bile duct stones who visited our hospital from January 2013 to June 2015 and underwent ERCP and cholecystolithotomy. A total of 292 patients were enrolled, and according to the presence or absence of recurrence of common bile duct stones, these patients were divided into recurrence group with 31 patients and non-recurrence group with 261 patients. The clinical data including age, sex, body mass index (BMI), and the conditions of the biliary tract and bile duct stones were compared between the two groups. The chi-square test was used for comparison of categorical data between groups, and the binary logistic regression was used for the analysis of factors that were screened out. ResultsThere were significant differences in the proportions of patients with a number of stones ≥2 or bile duct diameter ≥14 mm between the two groups (χ2=4.80 and 5.61, both P＜0.05). A previous history of cholecystectomy was an independent risk factor for the recurrence of common bile duct stones (OR=20.10, 95%CI： 4.11-98.25, P＜0.05). ConclusionA previous history of cholecystectomy increases the risk of recurrence of common bile duct stones after ERCP. [ABSTRACT FROM AUTHOR]

Objectives To investigate the early risk factors for pyogenic cholangitis in patients with common bile duct stones. MethodsThe clinical data of patients with common bile duct stones within 3 days after admission, who visited Qinghai Provincial People′s Hospital from January 2013 to June 2015, were collected, including sex, age, C-reactive protein (CRP), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), direct bilirubin (DBil), diameter of the common bile duct, diameter of the stones, oxygen partial pressure, and urobilinogen. The patients were divided into bile duct stone group and bile duct stone-pyogenic cholangitis group. The independent samples t-test was used for comparison of continuous data between groups, the chi-square test was used for comparison of categorical data between groups, and the binary logistic regression was used for the screening for risk factors. ResultsThere were significant differences in sex, CRP, ALP, GGT, DBil, diameter of the common bile duct, oxygen partial pressure, and urobilinogen between the bile duct stone group and the bile duct stone-pyogenic cholangitis group (all P＜0.05). The binary logistic regression analysis showed that sex (OR=4.24, P＜0.001), CRP ≥3 mg/dl (OR = 2.39, P = 0.030), GGT≥224 U/L (OR=4.33, P＜0.001), ALP ≥198 U/L (OR=2.76, P=0.010), DBil ＞73 μmol/L (OR=2.57, P=0.020), diameter of the common bile duct ≥13 mm (OR=8.21, P＜0.001), oxygen partial pressure ＜80 mm Hg (OR=31.23, P＜0.001), and urobilinogen ≥2+ (OR=2.28, P＜0.001) were risk factors for pyogenic cholangitis in patients with common bile duct stones. ConclusionThe risk factors for pyogenic cholangitis in patients with common bile duct stones can be detected in early stage, which helps with the selection of surgical timing and procedure. [ABSTRACT FROM AUTHOR]