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目的 探讨利尿合剂对慢性心力衰竭（CHF）患者血清高敏 C 反应蛋白（hs-CRP）、白细胞介素-6（IL-6）及脑利钠肽（BNP）的干预作用及其临床意义。方法选取 CHF 患者60例，随机分为观察组和对照组各30例。两组均行 CHF 常规治疗，在此基础上观察组加用利尿合剂（由呋塞米、硝酸甘油、多巴胺组成）治疗，疗程7 d。治疗前后检测两组血清 hs-CRP、IL-6、BNP 水平以及左室舒张末内径（LVEDD）、左室射血分数（LVEF）、心率（HR）的变化。结果治疗后，两组血清 hs-CRP、IL-6、BNP 均较治疗前下降（P 均＜0．05），且观察组较对照组下降更显著（P 均＜0．05）；治疗后，两组 LVEDD、LVEF、HR 指标均较治疗前改善（P 均＜0．05）；且观察组 LVEF 较对照组明显改善（P ＜0．05）。结论血清 hs-CRP、IL-6、BNP 水平升高是 CHF 发病的重要机制之一；利尿合剂能快速降低血清 hs-CRP、IL-6、BNP 水平，缓解心衰症状。 [ABSTRACT FROM AUTHOR]