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Objective: To investigate the effect of obstructive sleep apnea syndrome (OSAS) on left ventricular function, N-terminal pro-B-type natriuretic peptide (NT-proBNP), endothelin-1 (ET-1), and growth differentiation factor-15 (GDF-15) in patients with acute myocardial infarction (AMI). Methods: 136 AMI patients who underwent emergency PCI at our hospital from March 2020 to June 2022 were selected and divided into non OSAHS group (48 cases), mild OSAHS group (31 cases), moderate OSAHS group (29 cases), and severe OSAHS group (28 cases) based on the apnea hypopnea index (AHI) level. Left ventricular function indicators [left ventricular fractional shortening shortening (LVFS), left ventricular ejection fraction (LVEF)] were examined by echocardiography, and the levels of NT-proBNP, ET-1, GDF-15, creatine kinase (CK), creatine kinase isoenzyme MB (CK-MB), lactate dehydrogenase (LDH), and α-Hydroxybutyrate dehydrogenase (α-HBDH) were measured. Pearson correlation analysis was used to investigate the correlation between LVFS, LVEF, NT-proBNP, ET-1, GDF-15, and AHI; Multiple logistic regression analysis was used to analyze the risk factors of AMI with OSAHS. Results: (1) Comparison of LVFS and LVEF, the severe OSAHS groupmoderate OSAHS group>mild OSAHS group>non OSAHS group (P<0.05); (3) Comparison of CK, CK-MB, LDH, and α-HBDH levels, the severe OSAHS group>moderate OSAHS group>mild OSAHS group>non OSAHS group (P<0.05). (4) Pearson correlation analysis showed that: the LVFS, LVEF were negatively correlated with AHI (r=-0.632, -0.573, P<0.05), while NT-proBNP, ET-1, GDF-15 levels were positively correlated with AHI (r=0.596, 0.542, 0.517, P<0.05). (5) Logistic regression analysis shows that: LVFS (OR=6.379, 95%CI: 3.215~9.543), LVEF (OR=3.016, 95%CI: 1.364~4.668), NT-proBNP (OR=5.171, 95%CI: 2.316~8.025), ET-1 (OR=2.751, 95%CI: 1.334~4.168), GDF-15 (OR=2.447, 95%CI: 1.143~3.752), CK (OR=4.108, 95%CI: 1.615~6.602), CK-MB (OR=4.500, 95%CI: 1.860~7.139), and LDH (OR=3.435, 95%CI: 1.407~5.463) were independent risk factor for AMI with OSAHS (P<0.05). Conclusion: As the condition of OSAHS progresses, it may worsen left ventricular function, vascular endothelial function, and myocardial damage in AMI patients. The levels of NT proBNP, ET-1, and GDF-15 were increased may be risk factors for AMI with OSAHS. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of Zhejiang University (Science Edition) is the property of Journal of Zhejiang University (Science Edition) Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的 分析人工茶关节置接术患者术前血清清蛋白(ALB)对临床結局的影响。方法 选取2019 年1 12月 山东大学齐音医院行人工。关节置接术意者 176例,根据血清ALB诊断标准分为正常组(>35 g/L,153 例)和异常组(<35 g L, 23例),比较2组年齡、体重指数(BMI)、住院花费手术时间、总住院时间、术中输血量、术中失血量、术后引引流量及术后并发症发 主情况,结果2组术后并发症发生情况比校,差异有统计学意义(P<0,05),正常组术后死亡1例,异常组无死亡情混发生,差 异无统计学意义(P>0.05)。2组年龄、BMI、感住院时间外其余各指标比較,差开均无统计学意义(P>0.05),血清ALB水平 降低、住院时间长是人工栽关节直接术后并发症的危险因素P<0.05).结论 人工體膝关节置接术患者营养扶況有待改善, 米前血清ALB水平降低不利于患者特归及 預后. [ABSTRACT FROM AUTHOR]

Copyright of Practical Pharmacy & Clinical Remedies is the property of Editorial Department of Practical Pharmacy & Clinical Remedies and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To analyze the chromosome karyotypes of 1 775 high⁃risk maternal amniotic fluids，and to investigate the abnormal rate of various types of prenatal diagnosis indications and the type，frequency and clinical significance of fetal chromosome abnormalities. Methods From January 2012 to December 2014，1 782 cases of prenatal diagnosis were performed at the prenatal diagnosis center of the hospital，and their amniocentesis and amniotic fluid cell culture were performed. The 1 775 fetus karyotypes obtained were analyzed. Results One puncture failed and the puncture success rate was 99.94%. Abortion of amniotic fluid failed once in 12 cases，the success rate was 99.33%，and 6 cases gave up the second culture. A total of 1 775 karyotype analysis results were obtained. 1 775 cases of maternal communism detected 99 cases of various chromosome abnormalities，the total abnormal rate was 5.58%. Among them，the number of chromosomes was abnormal in 45 cases（2.54%），other chromosomal abnormalities in 54 cases（3.04%），including D and G Roche′s translocation in 3 cases， balanced translocation in 1 case，polymorphism in 50 cases. Among chromosome polymorphisms，the inversion of the chromosome 9 was the most common in 16 cases（32.00%）. Conclusion Amniocentesis and karyotype analysis of amniotic fluid cells are currently safe and reliable methods for prenatal diagnosis. Analysis of karyotype of amniotic fluid in high⁃risk mothers with indications for prenatal diagnosis can effectively reduce the birth of children with chromosomal abnormalities. [ABSTRACT FROM AUTHOR]