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Objective: To analyze the effect of Nuangqi Sanshenque patch combined with moxibustion on children with splenic deficiency diarrhea and its influence on intestinal microecology. Methods: 120 children with spleen deficiency diarrhea admitted to The First Affiliated Hospital of Henan University of Chinese Medicine from January 2022 to July 2023 were randomly divided into control group and observation group, 60 cases in each group. The control group was treated with bifidum triple viable bacteria capsule and montmorillonite powder; On the basis of the control group, the observation group was treated with warm umbilical Sanshenque patch combined with moxibustion. The moxibustion points were Shenque, Zhongwan, Zusanli, Tianshu, Pishu and Shenshu for 14 days. Symptom relief (normal time of stool traits and stop time of diarrhea) of the children in the two groups were recorded, and intestinal barrier function indexes (diamine oxidase, D-lactic acid), intestinal flora number (bifidobacterium, lactobacillus, fecal coccus, Escoli), serum inflammatory factors (interleukin-6, interleukin-8, tumor necrosis factor a) before and after treatment were detected. Results: Compared the control group, the observation group shit character normal time and diarrhea stop time are shorter (P<0.05). After treatment, the observation group of serum diamine oxidase, D-lactic acid levels are lower than the control group (P<0.05). After treatment, compared to control group and observation group serum interleukin 6 and interleukin 8, tumor necrosis factor alpha levels are lower (P<0.05). After treatment, compared to control group and observation group more the number of bifidobacterium, lactobacillus, less number of dung aureus, escherichia coli (P<0.05). Observation group total effective rate is 93.33%, compared to 83.33% of the control group (P<0.05). Conclusion: Nuanqi Sanshenque patch combined with moxibustion is effective in the treatment of children with splenic deficiency diarrhea, which is helpful to shorten the course of disease, improve intestinal barrier function and intestinal microecology. [ABSTRACT FROM AUTHOR]