1. Recommended Nuclear Data for the Production of Selected Therapeutic Radionuclides
- Author
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Yasuski Nagai, Roberto Capote, A.V. Ignatyuk, Alan L. Nichols, B. V. Carlson, Gui Nyun Kim, Saraswatula V. Suryanarayana, Sandor Takacs, Marco Verpelli, Aurelian Luca, Ondřej Lebeda, M.A. Kellett, Francois M. Nortier, F. G. Kondev, Jonathan W. Engle, Alex Hermanne, M. Hussain, Ferenc Tarkanyi, Tibor Kibedi, Haladhara Naik, Los Alamos National Laboratory (LANL), Institute of Physics and Power Engineering, IPPE, International Atomic Energy Agency [Vienna] (IAEA), Technological Institute of Aeronautics (ITA), Vrije Universiteit Brussel (VUB), Laboratoire National Henri Becquerel (LNHB), Département Métrologie Instrumentation & Information (DM2I), Laboratoire d'Intégration des Systèmes et des Technologies (LIST), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire d'Intégration des Systèmes et des Technologies (LIST), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Australian National University (ANU), Kyungpook National University [Daegu], Argonne National Laboratory [Lemont] (ANL), Government College University, Nuclear Physics Institute [Prague], Czech Academy of Sciences [Prague] (CAS), Horia Hulubei National Institute of Physics and Nuclear Engineering (NIPNE), IFIN-HH, Japan Atomic Energy Agency, Bhabha Atomic Research Centre (BARC), Government of India, Department of Atomic Energy, University of Surrey (UNIS), Institute for Nuclear Research [Budapest] (ATOMKI), Hungarian Academy of Sciences (MTA), IAEA, Vriendenkring VUB, Brussels Photonics Team, Applied Physics and Photonics, Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Département d'instrumentation Numérique (DIN (CEA-LIST)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), and Kyungpook National University [Daegu] (KNU)
- Subjects
Nuclear reaction ,cross-section ,Nuclear and High Energy Physics ,[PHYS.NUCL]Physics [physics]/Nuclear Theory [nucl-th] ,230U ,225Ac ,[SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine ,[PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex] ,01 natural sciences ,131Cs ,SHORT-LIVED NUCLIDE ,CROSS-SECTIONS ,EXCITATION-FUNCTIONS ,CYCLOTRON PRODUCTION ,XN REACTIONS ,THORIUM ,PROTONS ,TH-232 ,PARTICLE ,AC-225 ,Nuclear physics ,Human disease ,0103 physical sciences ,227Ac ,radionuclide-based therapies ,therapeutic applications ,nuclear medicine ,010306 general physics ,225Ra ,radionuclides ,Physics ,Radionuclide ,010308 nuclear & particles physics ,Generator (category theory) ,227Th ,178mTa ,178W ,Nuclear data ,Order (ring theory) ,uncertainties ,3. Good health ,230Pa ,Padé approximations ,Production (computer science) ,131Ba ,Radioactive decay - Abstract
International audience; Increasing interest in the treatment of human disease by means of targeted radionuclide-based therapies requires an accurate understanding of achievable yields and quantification of realisable degrees of purity. Important studies within a more extensive Coordinated Research Project of the International Atomic Energy Agency (IAEA CRP) have included in-depth assessments and evaluations of all available measured cross-section data for ten nuclear reactions leading to the formation of $^{131}$Cs, $^{131}$Ba, $^{225}$Ac, $^{225}$Ra, $^{227}$Th, $^{227}$Ac, $^{230}$U and $^{230}$Pa for various on-going and proposed therapeutic applications in nuclear medicine. Equivalent studies were also undertaken of possible reactions to produce the $^{178}$W/low-spin $^{178m}$Ta generator system that has been clinically applied in diagnosis by means of SPECT - these particular cross-section studies and recommendations are included in this paper for completeness. All available measured data have been critically reviewed and assessed to produce statistically consistent datasets. Selected datasets have been fitted by a least-squares method with Padé approximations of variable order to evaluate the production cross sections and corresponding uncertainties. New measurements have been made in some instances, and reported data have been adjusted to accommodate new nuclear decay or monitor reaction data which altered the original reported quantities adversely. Insufficient measured data are available in many cases to permit a reliable evaluation of cross sections, and these instances are discussed. Recommended therapeutic radionuclide production reaction data and their uncertainties are available on the Web page of the IAEA Nuclear Data Section at www-nds.iaea.org/radionuclides/ and also at the IAEA medical portal www-ds.iaea.org/medportal/
- Published
- 2019
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