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// Nour Ghazzaui 1,* , Alexis Saintamand 1,* , Hussein Issaoui 1 , Christelle Vincent-Fabert 1 and Yves Denizot 1 1 Universite de Limoges, Centre National de la Recherche Scientifique, CNRS UMR, France * These authors have have contributed equally to this work Correspondence to: Yves Denizot, email: // Keywords : c-myc, 3’ regulatory region, lymphomagenesis, transgenic mice, HDAC Received : August 15, 2016 Accepted : October 05, 2016 Published : October 08, 2016 Abstract Deregulation and mutations of c-myc have been reported in multiple mature B-cell malignancies such as Burkitt lymphoma, myeloma and plasma cell lymphoma. After translocation into the immunoglobulin heavy chain (IgH) locus, c-myc is constitutively expressed under the control of active IgH cis -regulatory enhancers. Those located in the IgH 3’ regulatory region (3’RR) are master control elements of transcription. Over the past decade numerous convincing demonstrations of 3’RR’s contribution to mature c-myc-induced lymphomagenesis have been made using transgenic models with various types of IgH-c-myc translocations and transgenes. This review highlights how IgH 3’RR physiological functions play a critical role in c-myc deregulation during lymphomagenesis.