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Your search keyword '"6-nicotinoylmorphine"' showing total 2 results
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2 results on '"6-nicotinoylmorphine"'

1. Pharmacokinetics of intramuscular nicomorphine and its metabolites in man.

Author

Koopman-Kimenai, P., Vree, T., Booij, L., Dirksen, R., and Nijhuis, G.

Abstract

After i.m. injection nicomorphine is relatively slowly absorbed from the muscular depot and is found in the serum for approximately 1 h. The rate of absorption differs between patients and governs the overall pharmacokinetic profile of the compound. The relative AUCs were nicomorphine 18%, 6-nicotinoylmorphine 17%, and morphine 65%. Nicomorphine and 6-nicotinoylmorphine have significantly higher AUCs after i.m. injection than after i.v. injection, while the AUC of morphine and the total AUC show no difference between the two modes of administration. [ABSTRACT FROM AUTHOR]

Published
1991
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2. High-performance liquid chromatography and preliminary pharmacokinetics of nicomorphine and its metabolites 3-nicotinoyl- and 6-nicotinoylmorphine and morphine

Author

L.H.D.J. Booy, T.B. Vree, P.M. Koopman-Kimenai, M.W. Cress-Tijhuis, and G. Drijkoningen

Subjects
Morphine Derivatives, Chromatography, 6-nicotinoylmorphine, Morphine, Metabolite, Electrochemical detector, Nicotinic Acids, General Chemistry, Prodrug, High-performance liquid chromatography, Nicomorphine, chemistry.chemical_compound, Kinetics, chemistry, Pharmacokinetics, medicine, Humans, Spectrophotometry, Ultraviolet, Biotransformation, Chromatography, High Pressure Liquid, medicine.drug
Published
1987

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