Search

Objectives. To collect the data about the consumption of digoxin, evaluate the tendencies towards usage of this drug during 2004–2007, and to find departments, which cover the main part of digoxin consumption in a tertiary hospital. To evaluate the intensity of serum digoxin concentration measurements during 2005–2007. Material and methods. Our study was carried out in a tertiary hospital with 2600 beds and 63 departments. Consumption of digoxin is expressed in defined daily doses per 100 occupied beds daily during 2004–2007. All serum concentration measurements in 2005–2007 were evaluated. Results. The main consumers of digoxin in 2007 were the Units of Endocrinology, Pulmonology and Immunology, Cardiology II, Neurosurgical Reanimation and Intensive Care, Neurology, Eye Disorders I, Intensive Care Unit of Cardiology; they consumed 51.05% of total digoxin. In total, 58 digoxin measurements were performed in 2005, 89 in 2006, and 64 in 2007. The intensity of serum concentration measurements for digoxin is 1/147 (one measurement for 147 defined daily doses) in 2005, 1/89 in 2006, and 1/107 in 2007. These results show that intensity of serum digoxin concentration measurements is low. Conclusions. Twenty-two out of the 63 departments cover 90% of digoxin consumption per year. The changes in digoxin consumption were not statistically significantly different in 2004– 2007. There was a tendency towards an increase in serum digoxin concentration measurements during the 3-year period. Digoxin concentration outside therapeutic ranges was established in about half of all cases in 2005–2006, but there was an increase in normal serum concentration in 2007.

Darbo tikslas. Ištirti IA klasės antiaritminio preparato prokainamido ir naujų sulfonilkarbamidinių jo analogų PA20, PA23, PA28 ir PA53 poveikį jūrų kiaulyčių prieširdžio veikimo potencialų trukmei bei susitraukimo jėgai karbacholu stimuliuotų muskarininių receptorių sąlygomis. Eksperimentiniai tyrimai atlikti naudojant standartinę miokardo elektromechaninio aktyvumo registravimo metodiką. Perfuzuojant prieširdžio raumenėlius Tyrodė fiziologiniu tirpalu (kontrolė), veikimo potencialų trukmės, esant 90 proc. (VP90) ir 50 proc. (VP50) repoliarizacijos lygiams, buvo atitinkamai 92,5±4,5 ms, 44,4±2,9 ms (n=18), susitraukimo jėga – 2,7±0,5 mN (n=12). Muskarininių acetilcholino receptorių agonistas ir KAch kanalų aktyviklis karbacholas (10–6M) mažino VP90 iki 32,4±2,4 proc., VP50 – 25,4±2,2 proc. (n=18) (p

QT interval changes and it's components evaluation by the means of computerized 100 lead ECG and serial 12 standard lead ECG analysis system is described. Main attention is paid on the repolarization of the heart - JT interval. In evaluation of it's changes and distribution three elements are stressed out: 1) JTd - dispersion of JT interval on the surface of the chest, evaluated for synchronously registered cardiocycle in 100 leads or in 12 standard leads as well, 2) JTv - variability of JT interval in time, evaluated during antiarrhythmic therapy by the means of system with 12 standard leads synchronous recording. [...].