419 results on '"A, Cornen"'
Search Results
2. The impact of human expert visual inspection on the discovery of strong gravitational lenses
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Rojas, Karina, Collett, Thomas E., Ballard, Daniel, Magee, Mark R., Birrer, Simon, Buckley-Geer., Elizabeth, Chan, James H. H., Clément, Benjamin, Diego, José M., Gentile, Fabrizio, González, Jimena, Joseph, Rémy, Mastache, Jorge, Schuldt, Stefan, Tortora, Crescenzo, Verdugo, Tomás, Verma, Aprajita, Daylan, Tansu, Millon, Martin, Jackson, Neal, Dye, Simon, Melo, Alejandra, Mahler, Guillaume, Ogando, Ricardo L. C., Courbin, Frédéric, Fritz, Alexander, Herle, Aniruddh, Barroso, Javier A. Acevedo, Cañameras, Raoul, Cornen, Claude, Dhanasingham, Birendra, Glazebrook, Karl, Martinez, Michael N., Ryczanowski, Dan, Savary, Elodie, Góis-Silva, Filipe, Ureña-López, L. Arturo, Wiesner, Matthew P., Wilde, Joshua, Calçada, Gabriel Valim, Cabanac, Rémi, Pan, Yue, Sierra, Isaac, Despali, Giulia, Cavalcante-Gomes, Micaele V., Macmillan, Christine, Maresca, Jacob, Grudskaia, Aleksandra, O'Donnell, Jackson H., Paic, Eric, Niemiec, Anna, de la Bella, Lucia F., Bromley, Jane, Williams, Devon M., More, Anupreeta, and Levine, Benjamin C.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We investigate the ability of human 'expert' classifiers to identify strong gravitational lens candidates in Dark Energy Survey like imaging. We recruited a total of 55 people that completed more than 25$\%$ of the project. During the classification task, we present to the participants 1489 images. The sample contains a variety of data including lens simulations, real lenses, non-lens examples, and unlabeled data. We find that experts are extremely good at finding bright, well-resolved Einstein rings, whilst arcs with $g$-band signal-to-noise less than $\sim$25 or Einstein radii less than $\sim$1.2 times the seeing are rarely recovered. Very few non-lenses are scored highly. There is substantial variation in the performance of individual classifiers, but they do not appear to depend on the classifier's experience, confidence or academic position. These variations can be mitigated with a team of 6 or more independent classifiers. Our results give confidence that humans are a reliable pruning step for lens candidates, providing pure and quantifiably complete samples for follow-up studies., Comment: 16 pages, 20 Figures
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- 2023
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3. Hubble Asteroid Hunter: II. Identifying strong gravitational lenses in HST images with crowdsourcing
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Garvin, Emily O., Kruk, Sandor, Cornen, Claude, Bhatawdekar, Rachana, Cañameras, Raoul, and Merín, Bruno
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
The Hubble Space Telescope (HST) archives constitute a rich dataset of high resolution images to mine for strong gravitational lenses. While many HST programs specifically target strong lenses, they can also be present by coincidence in other HST observations. We aim to identify non-targeted strong gravitational lenses in almost two decades of images from the ESA it Hubble Space Telescope archive (eHST), without any prior selection on the lens properties. We used crowdsourcing on the Hubble Asteroid Hunter (HAH) citizen science project to identify strong lenses, alongside asteroid trails, in publicly available large field-of-view HST images. We visually inspected 2354 objects tagged by citizen scientists as strong lenses to clean the sample and identify the genuine lenses. We report the detection of 252 strong gravitational lens candidates, which were not the primary targets of the HST observations. 198 of them are new, not previously reported by other studies, consisting of 45 A grades, 74 B grades and 79 C grades. The majority are galaxy-galaxy configurations. The newly detected lenses are, on average, 1.3 magnitudes fainter than previous HST searches. This sample of strong lenses with high resolution HST imaging is ideal to follow-up with spectroscopy, for lens modelling and scientific analyses. This paper presents an unbiased search of lenses, which enabled us to find a high variety of lens configurations, including exotic lenses. We demonstrate the power of crowdsourcing in visually identifying strong lenses and the benefits of exploring large archival datasets. This study shows the potential of using crowdsourcing in combination with artificial intelligence for the detection and validation of strong lenses in future large-scale surveys such as ESA's future mission Euclid or in JWST archival images., Comment: 24 page, 14 figures, 5 tables, accepted for publication in A&A June 28 2022
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- 2022
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4. Natural killer cell therapies
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Vivier, Eric, Rebuffet, Lucas, Narni-Mancinelli, Emilie, Cornen, Stéphanie, Igarashi, Rob Y., and Fantin, Valeria R.
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- 2024
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5. The lens SW05 J143454.4+522850: a fossil group at redshift 0.6?
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Denzel, Philipp, Çatmabacak, Onur, Coles, Jonathan P., Cornen, Claude, Feldmann, Robert, Ferreras, Ignacio, Palmer, Xanthe Gwyn, Küng, Rafael, Leier, Dominik, Saha, Prasenjit, and Verma, Aprajita
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Astrophysics - Astrophysics of Galaxies - Abstract
Fossil groups are considered the end product of natural galaxy group evolution in which group members sink towards the centre of the gravitational potential due to dynamical friction, merging into a single, massive, and X-ray bright elliptical. Since gravitational lensing depends on the mass of a foreground object, its mass concentration, and distance to the observer, we can expect lensing effects of such fossil groups to be particularly strong. This paper explores the exceptional system $\mathrm{J}143454.4+522850$. We combine gravitational lensing with stellar population-synthesis to separate the total mass of the lens into stars and dark matter. The enclosed mass profiles are contrasted with state-of-the-art galaxy formation simulations, to conclude that SW05 is likely a fossil group with a high stellar to dark matter mass fraction $0.027\pm0.003$ with respect to expectations from abundance matching $0.012\pm0.004$, indicative of a more efficient conversion of gas into stars in fossil groups., Comment: 8 pages, 9 figures, submitted to MNRAS
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- 2021
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6. Survey of Gravitationally-lensed Objects in HSC Imaging (SuGOHI). VI. Crowdsourced lens finding with Space Warps
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Sonnenfeld, Alessandro, Verma, Aprajita, More, Anupreeta, Baeten, Elisabeth, Macmillan, Christine, Wong, Kenneth C., Chan, James H. H., Jaelani, Anton T., Lee, Chien-Hsiu, Oguri, Masamune, Rusu, Cristian E., Veldthuis, Marten, Trouille, Laura, Marshall, Philip J., Hutchings, Roger, Allen, Campbell, Donnell, James O', Cornen, Claude, Davis, Christopher, McMaster, Adam, Lintott, Chris, and Miller, Grant
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Strong lenses are extremely useful probes of the distribution of matter on galaxy and cluster scales at cosmological distances, but are rare and difficult to find. The number of currently known lenses is on the order of 1,000. We wish to use crowdsourcing to carry out a lens search targeting massive galaxies selected from over 442 square degrees of photometric data from the Hyper Suprime-Cam (HSC) survey. We selected a sample of $\sim300,000$ galaxies with photometric redshifts in the range $0.2 < z_{phot} < 1.2$ and photometrically inferred stellar masses $\log{M_*} > 11.2$. We crowdsourced lens finding on this sample of galaxies on the Zooniverse platform, as part of the Space Warps project. The sample was complemented by a large set of simulated lenses and visually selected non-lenses, for training purposes. Nearly 6,000 citizen volunteers participated in the experiment. In parallel, we used YattaLens, an automated lens finding algorithm, to look for lenses in the same sample of galaxies. Based on a statistical analysis of classification data from the volunteers, we selected a sample of the most promising $\sim1,500$ candidates which we then visually inspected: half of them turned out to be possible (grade C) lenses or better. Including lenses found by YattaLens or serendipitously noticed in the discussion section of the Space Warps website, we were able to find 14 definite lenses, 129 probable lenses and 581 possible lenses. YattaLens found half the number of lenses discovered via crowdsourcing. Crowdsourcing is able to produce samples of lens candidates with high completeness and purity, compared to currently available automated algorithms. A hybrid approach, in which the visual inspection of samples of lens candidates pre-selected by discovery algorithms and/or coupled to machine learning is crowdsourced, will be a viable option for lens finding in the 2020s., Comment: Published version
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- 2020
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7. 10th antibody industrial symposium: new developments in antibody and adoptive cell therapies
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Ana Antunes, Luis Alvarez-Vallina, Federico Bertoglio, Nicolas Bouquin, Stéphanie Cornen, Francis Duffieux, Pierre Ferré, Raphaëlle Gillet, Christian Jorgensen, Mark B Leick, Bernard Maillère, Hélène Negre, Mireia Pelegrin, Nicolas Poirier, Dietmar Reusch, Bruno Robert, Guy Serre, Alain Vicari, Martin Villalba, Christoph Volpers, Gavin Vuddamalay, Hervé Watier, Thierry Wurch, Lennart Zabeau, Stefan Zielonka, Baolin Zhang, Alain Beck, and Pierre Martineau
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Antibody engineering ,Antibody industrial symposium ,antibody-related molecules ,biotherapeutics ,cell-based therapies ,congress ,Therapeutics. Pharmacology ,RM1-950 ,Immunologic diseases. Allergy ,RC581-607 - Abstract
ABSTRACTThe annual “Antibody Industrial Symposium”, co-organized by LabEx MAbImprove and MabDesign, held its 10th anniversary edition in Montpellier, France, on June 28–29, 2022. The meeting focused on new results and concepts in antibody engineering (naked, mono- or multi-specific, conjugated to drugs or radioelements) and also on new cell-based therapies, such as chimeric antigenic receptor (CAR)-T cells. The symposium, which brought together scientists from academia and industry, also addressed issues concerning the production of these molecules and cells, and the necessary steps to ensure a strong intellectual property protection of these new molecules and approaches. These two days of exchanges allowed a rich discussion among the various actors in the field of therapeutic antibodies.
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- 2023
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8. Early pacemaker insertion after aortic valve replacement with an Edwards Intuity sutureless valve
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Mechulan, Alexis, Demoulin, Raphaël, Dieuzaide, Pierre, Peret, Angélique, Vaillant, Alain, Vicat, Jacques, Bouharaoua, Ahmed, Leude-Vaillant, Elisabeth, Cornen, Alain, and Prevot, Sébastien
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- 2022
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9. AGN photoionization of gas in companion galaxies as a probe of AGN radiation in time and direction
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Keel, William C., Bennert, Vardha N., Pancoast, Anna, Harris, Chelsea E., Nierenberg, Anna, Chojnowaki, S. Drew, Moiseev, Alexei V., Oparin, Dmitry V., Lintott, Chris J., Schawinski, Kevin, Mitchell, Graham, and Cornen, Claude
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Astrophysics - Astrophysics of Galaxies - Abstract
We consider AGN photoionization of gas in companion galaxies (cross-ionization) as a way to sample the intensity of AGN radiation in both direction and time, independent of the gas properties of the AGN host galaxies. From an initial set of 212 AGN+companion systems, identified with the help of Galaxy Zoo participants, we obtained long-slit optical spectra of 32 pairs which were a priori likely to show cross-ionization based on projected separation or angular extent of the companion. From emission-line ratios, 10 of these systems are candidates for cross-ionization, roughly the fraction expected if most AGN have ionization cones with 70-degree opening angles. Among these, Was 49 remains the strongest nearby candidate. NGC 5278/9 and UGC 6081 are dual-AGN systems with tidal debris, complicating identification of cross-ionization. The two weak AGN in the NGC 5278/9 system ionize gas filaments to a projected radius 14 kpc from each galaxy. In UGC 6081, an irregular high-ionization emission region encompasses both AGN, extending more than 15 kpc from each. The observed AGN companion galaxies with and without signs of external AGN photoionization have similar distributions in estimated incident AGN flux, suggesting that geometry of escaping radiation or long-term variability control this facet of the AGN environment. This parallels conclusions for luminous QSOs based on the proximity effect among Lyman-alpha absorbers. In some galaxies, mismatch between spectroscopic classifications in the common BPT diagram and the intensity of weaker He II and [Ne V] emission lines highlights the limits of common classifications in low-metallicity environments., Comment: Accepted version to appear in MNRAS. New version has spectra showing AGN ionization in NGC 5278/9 filaments and tunable-filter mapping of clouds around UGC 6081 system
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- 2017
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10. Models of gravitational lens candidates from Space Warps CFHTLS
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Küng, Rafael, Saha, Prasenjit, Ferreras, Ignacio, Baeten, Elisabeth, Coles, Jonathan, Cornen, Claude, Macmillan, Christine, Marshall, Phil, More, Anupreeta, Oswald, Lucy, Verma, Aprajita, and Wilcox, Julianne K.
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Astrophysics - Astrophysics of Galaxies - Abstract
We report modelling follow-up of recently-discovered gravitational-lens candidates in the Canada France Hawaii Telescope Legacy Survey. Lens modelling was done by a small group of specially-interested volunteers from the SpaceWarps citizen-science community who originally found the candidate lenses. Models are categorised according to seven diagnostics indicating (a) the image morphology and how clear or indistinct it is, (b) whether the mass map and synthetic lensed image appear to be plausible, and (c) how the lens-model mass compares with the stellar mass and the abundance-matched halo mass. The lensing masses range from ~10^11 Msun to >10^13 Msun. Preliminary estimates of the stellar masses show a smaller spread in stellar mass (except for two lenses): a factor of a few below or above ~10^11 Msun. Therefore, we expect the stellar-to-total mass fraction to decline sharply as lensing mass increases. The most massive system with a convincing model is J1434+522 (SW05). The two low-mass outliers are J0206-095 (SW19) and J2217+015 (SW42); if these two are indeed lenses, they probe an interesting regime of very low star-formation efficiency. Some improvements to the modelling software (SpaghettiLens), and discussion of strategies regarding scaling to future surveys with more and frequent discoveries, are included., Comment: 16 pages, 10 figures, 1 table, online supplement table_1.csv contains additional detailed numbers shown in table 1 and figure 7
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- 2017
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11. Space Warps: I. Crowd-sourcing the Discovery of Gravitational Lenses
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Marshall, Philip J., Verma, Aprajita, More, Anupreeta, Davis, Christopher P., More, Surhud, Kapadia, Amit, Parrish, Michael, Snyder, Chris, Wilcox, Julianne, Baeten, Elisabeth, Macmillan, Christine, Cornen, Claude, Baumer, Michael, Simpson, Edwin, Lintott, Chris J., Miller, David, Paget, Edward, Simpson, Robert, Smith, Arfon M., Küng, Rafael, Saha, Prasenjit, Collett, Thomas E., and Tecza, Matthias
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We describe Space Warps, a novel gravitational lens discovery service that yields samples of high purity and completeness through crowd-sourced visual inspection. Carefully produced colour composite images are displayed to volunteers via a web- based classification interface, which records their estimates of the positions of candidate lensed features. Images of simulated lenses, as well as real images which lack lenses, are inserted into the image stream at random intervals; this training set is used to give the volunteers instantaneous feedback on their performance, as well as to calibrate a model of the system that provides dynamical updates to the probability that a classified image contains a lens. Low probability systems are retired from the site periodically, concentrating the sample towards a set of lens candidates. Having divided 160 square degrees of Canada-France-Hawaii Telescope Legacy Survey (CFHTLS) imaging into some 430,000 overlapping 82 by 82 arcsecond tiles and displaying them on the site, we were joined by around 37,000 volunteers who contributed 11 million image classifications over the course of 8 months. This Stage 1 search reduced the sample to 3381 images containing candidates; these were then refined in Stage 2 to yield a sample that we expect to be over 90% complete and 30% pure, based on our analysis of the volunteers performance on training images. We comment on the scalability of the SpaceWarps system to the wide field survey era, based on our projection that searches of 10$^5$ images could be performed by a crowd of 10$^5$ volunteers in 6 days., Comment: 21 pages, 13 figures, MNRAS accepted, minor to moderate changes in this version
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- 2015
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12. Space Warps II. New Gravitational Lens Candidates from the CFHTLS Discovered through Citizen Science
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More, Anupreeta, Verma, Aprajita, Marshall, Philip J., More, Surhud, Baeten, Elisabeth, Wilcox, Julianne, Macmillan, Christine, Cornen, Claude, Kapadia, Amit, Parrish, Michael, Snyder, Chris, Davis, Christopher P., Gavazzi, Raphael, Lintott, Chris J., Simpson, Robert, Miller, David, Smith, Arfon M., Paget, Edward, Saha, Prasenjit, Küng, Rafael, and Collett, Thomas E.
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We report the discovery of 29 promising (and 59 total) new lens candidates from the CFHT Legacy Survey (CFHTLS) based on about 11 million classifications performed by citizen scientists as part of the first Space Warps lens search. The goal of the blind lens search was to identify lens candidates missed by robots (the RingFinder on galaxy scales and ArcFinder on group/cluster scales) which had been previously used to mine the CFHTLS for lenses. We compare some properties of the samples detected by these algorithms to the Space Warps sample and find them to be broadly similar. The image separation distribution calculated from the Space Warps sample shows that previous constraints on the average density profile of lens galaxies are robust. SpaceWarps recovers about 65% of known lenses, while the new candidates show a richer variety compared to those found by the two robots. This detection rate could be increased to 80% by only using classifications performed by expert volunteers (albeit at the cost of a lower purity), indicating that the training and performance calibration of the citizen scientists is very important for the success of Space Warps. In this work we present the SIMCT pipeline, used for generating in situ a sample of realistic simulated lensed images. This training sample, along with the false positives identified during the search, has a legacy value for testing future lens finding algorithms. We make the pipeline and the training set publicly available., Comment: 23 pages, 12 figures, MNRAS accepted, minor to moderate changes in this version
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- 2015
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13. The Red Radio Ring: a gravitationally lensed hyperluminous infrared radio galaxy at z=2.553 discovered through citizen science
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Geach, J. E., More, A., Verma, A., Marshall, P. J., Jackson, N., Belles, P. -E., Beswick, R., Baeten, E., Chavez, M., Cornen, C., Cox, B. E., Erben, T., Erickson, N. J., Garrington, S., Harrison, P. A., Harrington, K., Hughes, D. H., Ivison, R. J., Jordan, C., Lin, Y. -T., Leauthaud, A., Lintott, C., Lynn, S., Kapadia, A., Kneib, J. -P., Macmillan, C., Makler, M., Miller, G., Montana, A., Mujica, R., Muxlow, T., Narayanan, G., Briain, D. O, O'Brien, T., Oguri, M., Paget, E., Parrish, M., Ross, N. P., Rozo, E., Rusu, E., Rykoff, E. S., Sanchez-Arguelles, D., Simpson, R., Snyder, C., Schloerb, F. P., Tecza, M., Van Waerbeke, L., Wilcox, J., Viero, M., Wilson, G. W., Yun, M. S., and Zeballos, M.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We report the discovery of a gravitationally lensed hyperluminous infrared galaxy (L_IR~10^13 L_sun) with strong radio emission (L_1.4GHz~10^25 W/Hz) at z=2.553. The source was identified in the citizen science project SpaceWarps through the visual inspection of tens of thousands of iJKs colour composite images of Luminous Red Galaxies (LRGs), groups and clusters of galaxies and quasars. Appearing as a partial Einstein ring (r_e~3") around an LRG at z=0.2, the galaxy is extremely bright in the sub-millimetre for a cosmological source, with the thermal dust emission approaching 1 Jy at peak. The redshift of the lensed galaxy is determined through the detection of the CO(3-2) molecular emission line with the Large Millimetre Telescope's Redshift Search Receiver and through [OIII] and H-alpha line detections in the near-infrared from Subaru/IRCS. We have resolved the radio emission with high resolution (300-400 mas) eMERLIN L-band and JVLA C-band imaging. These observations are used in combination with the near-infrared imaging to construct a lens model, which indicates a lensing magnification of ~10x. The source reconstruction appears to support a radio morphology comprised of a compact (<250 pc) core and more extended component, perhaps indicative of an active nucleus and jet or lobe., Comment: 9 pages, 7 figures, published in MNRAS
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- 2015
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14. Gravitational lens modelling in a citizen science context
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Küng, Rafael, Saha, Prasenjit, More, Anupreeta, Baeten, Elisabeth, Coles, Jonathan, Cornen, Claude, Macmillan, Christine, Marshall, Phil, More, Surhud, Odermatt, Jonas, Verma, Aprajita, and Wilcox, Julianne K.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We develop a method to enable collaborative modelling of gravitational lenses and lens candidates, that could be used by non-professional lens enthusiasts. It uses an existing free-form modelling program (glass), but enables the input to this code to be provided in a novel way, via a user-generated diagram that is essentially a sketch of an arrival-time surface. We report on an implementation of this method, SpaghettiLens, which has been tested in a modelling challenge using 29 simulated lenses drawn from a larger set created for the Space Warps citizen science strong lens search. We find that volunteers from this online community asserted the image parities and time ordering consistently in some lenses, but made errors in other lenses depending on the image morphology. While errors in image parity and time ordering lead to large errors in the mass distribution, the enclosed mass was found to be more robust: the model-derived Einstein radii found by the volunteers were consistent with those produced by one of the professional team, suggesting that given the appropriate tools, gravitational lens modelling is a data analysis activity that can be crowd-sourced to good effect. Ideas for improvement are discussed, these include (a) overcoming the tendency of the models to be shallower than the correct answer in test cases, leading to systematic overestimation of the Einstein radius by 10 per cent at present, and (b) detailed modelling of arcs., Comment: 10 pages, 12 figures
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- 2015
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15. A survey of Phlebotomine sand flies across their northern distribution range limit in Western Europe
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Risueño, J., primary, Bersihand, S., additional, Bender, C., additional, Cornen, T., additional, De Boer, K., additional, Ibáñez-Justicia, A., additional, Rey, D., additional, Rozier, Y., additional, Schneider, A., additional, Stroo, A., additional, Vanslembrouck, A., additional, Van Bortel, W., additional, Weigand, A., additional, Zambianchi, D., additional, Pérez Cutillas, P., additional, Oerther, S., additional, Braks, M., additional, Wint, G.R.W., additional, Berriatua, E., additional, and Schaffner, F., additional
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- 2024
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16. Multifunctional Natural Killer Cell Engagers Targeting NKp46 Trigger Protective Tumor Immunity
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Gauthier, Laurent, Morel, Ariane, Anceriz, Nadia, Rossi, Benjamin, Blanchard-Alvarez, Audrey, Grondin, Gwendoline, Trichard, Sylvia, Cesari, Cédric, Sapet, Melody, Bosco, Frédéric, Rispaud-Blanc, Hélène, Guillot, Franceline, Cornen, Stéphanie, Roussel, Alain, Amigues, Béatrice, Habif, Guillaume, Caraguel, Flavien, Arrufat, Sandrine, Remark, Romain, Romagné, François, Morel, Yannis, Narni-Mancinelli, Emilie, and Vivier, Eric
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- 2019
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17. Targeting MICA/B with cytotoxic therapeutic antibodies leads to tumor control [version 2; peer review: 2 approved]
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Mathieu Bléry, Manel Mrabet-Kraiem, Ariane Morel, Florence Lhospice, Delphine Bregeon, Cécile Bonnafous, Laurent Gauthier, Benjamin Rossi, Romain Remark, Stéphanie Cornen, Nadia Anceriz, Nicolas Viaud, Sylvia Trichard, Sabrina Carpentier, Alix Joulin-Giet, Gwendoline Grondin, Veronika Liptakova, Younghoon Kim, Laurent Daniel, Aurélie Haffner, Nicolas Macagno, Laurent Pouyet, Ivan Perrot, Carine Paturel, Yannis Morel, Alexander Steinle, François Romagné, Emilie Narni-Mancinelli, and Eric Vivier
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Science ,Social Sciences - Abstract
Background: MICA and MICB are tightly regulated stress-induced proteins that trigger the immune system by binding to the activating receptor NKG2D on cytotoxic lymphocytes. MICA and MICB are highly polymorphic molecules with prevalent expression on several types of solid tumors and limited expression in normal/healthy tissues, making them attractive targets for therapeutic intervention. Methods: We have generated a series of anti-MICA and MICB cross-reactive antibodies with the unique feature of binding to the most prevalent isoforms of both these molecules. Results: The anti-MICA and MICB antibody MICAB1, a human IgG1 Fc-engineered monoclonal antibody (mAb), displayed potent antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) of MICA/B-expressing tumor cells in vitro. However, it showed insufficient efficiency against solid tumors in vivo, which prompted the development of antibody-drug conjugates (ADC). Indeed, optimal tumor control was achieved with MICAB1-ADC format in several solid tumor models, including patient-derived xenografts (PDX) and carcinogen-induced tumors in immunocompetent MICAgen transgenic mice. Conclusions: These data indicate that MICA and MICB are promising targets for cytotoxic immunotherapy.
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- 2021
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18. 3PC-006 Stability study of clobazam liquid oral forms for paediatric patients
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Leroy, L Régnier, AL, primary, Le Potier Cornen, N, additional, Jouan, G, additional, Madigand, B, additional, Boivin, PN, additional, and Lester, MA, additional
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- 2024
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19. Micra AV leadless pacemaker implantation after transcatheter aortic valve implantation: 1-year follow-up
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Mechulan, A., primary, Prevot, S., additional, Peret, A., additional, Nait-Saidi, L., additional, Miliani, I., additional, Lemann, T., additional, Vaugrenard, T., additional, Houamria, S., additional, Leude-Vaillant, E., additional, Vaillant, A., additional, Cornen, A., additional, Latiere, B., additional, Giacomoni, M.P., additional, Collet, F., additional, Bechet, V., additional, Bouharaoua, A., additional, and Dieuzaide, P., additional
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- 2024
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20. Chemotherapy and tumor immunity : Inducing senescence in tumor cells stimulates antitumor innate immune responses
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Cornen, Stéphanie and Vivier, Eric
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- 2018
21. Comparison of mechanical properties of C-S-H and portlandite between nano-indentation experiments and a modeling approach using various simulation techniques
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Fu, Jia, Kamali-Bernard, Siham, Bernard, Fabrice, and Cornen, Marilyne
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- 2018
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22. Stress release-induced interfacial twin boundary ω phase formation in a β type Ti-based single crystal displaying stress-induced α” martensitic transformation
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Yang, Y., Castany, P., Bertrand, E., Cornen, M., Lin, J.X., and Gloriant, T.
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- 2018
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23. Harnessing innate immunity in cancer therapy
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Demaria, Olivier, Cornen, Stéphanie, Daëron, Marc, Morel, Yannis, Medzhitov, Ruslan, and Vivier, Eric
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Forecasts and trends ,Market trend/market analysis ,Cancer treatment -- Forecasts and trends ,Immunotherapy -- Forecasts and trends ,Cancer -- Care and treatment - Abstract
Author(s): Olivier Demaria [sup.1] , Stéphanie Cornen [sup.1] , Marc Daëron [sup.2] [sup.3] , Yannis Morel [sup.1] , Ruslan Medzhitov [sup.4] , Eric Vivier [sup.1] [sup.2] [sup.5] Author Affiliations: (1) [...], New therapies that promote antitumour immunity have been recently developed. Most of these immunomodulatory approaches have focused on enhancing T-cell responses, either by targeting inhibitory pathways with immune checkpoint inhibitors, or by targeting activating pathways, as with chimeric antigen receptor T cells or bispecific antibodies. Although these therapies have led to unprecedented successes, only a minority of patients with cancer benefit from these treatments, highlighting the need to identify new cells and molecules that could be exploited in the next generation of immunotherapy. Given the crucial role of innate immune responses in immunity, harnessing these responses opens up new possibilities for long-lasting, multilayered tumour control. The authors review recent developments in our understanding of the antitumour effects of the innate immune system and how this system could be harnessed in the clinic.
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- 2019
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24. From opening to subduction of an oceanic domain constrained by LA-ICP-MS U-Pb zircon dating (Variscan belt, Southern Armorican Massif, France)
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Paquette, J.-L., Ballèvre, M., Peucat, J.-J., and Cornen, G.
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- 2017
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25. Impact of a vaccination programme in children vaccinated with ProQuad, and ProQuad-specific effectiveness against varicella in the Veneto region of Italy
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Carlo Giaquinto, Giovanni Gabutti, Vincenzo Baldo, Marco Villa, Lara Tramontan, Nadia Raccanello, Francesca Russo, Chiara Poma, Antonio Scamarcia, Luigi Cantarutti, Rebecca Lundin, Emilia Perinetti, Xavier Cornen, Stéphane Thomas, Céline Ballandras, Audrey Souverain, and Susanne Hartwig
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Varicella ,Vaccine ,Effectiveness ,Impact ,ProQuad ,Italy ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Monovalent varicella vaccines have been available in the Veneto Region of Italy since 2004. In 2006, a single vaccine dose was added to the immunisation calendar for children aged 14 months. ProQuad®, a quadrivalent measles-mumps-rubella-varicella vaccine, was introduced in May 2007 and used, among other varicella vaccines, until October 2008. This study aimed to evaluate the effectiveness of a single dose of ProQuad, and the population impact of a vaccination program (VP) against varicella of any severity in children who received a first dose of ProQuad at 14 months of age in the Veneto Region, Methods All children born in 2006/2007, i.e., eligible for varicella vaccination after ProQuad was introduced, were retrospectively followed through individual-level data linkage between the Pedianet database (varicella cases) and the Regional Immunization Database (vaccination status). The direct effectiveness of ProQuad was estimated as the incidence rate of varicella in ProQuad-vaccinated children aged
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- 2018
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26. The impact of human expert visual inspection on the discovery of strong gravitational lenses
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Rojas, Karina, primary, Collett, Thomas E, additional, Ballard, Daniel, additional, Magee, Mark R, additional, Birrer, Simon, additional, Buckley-Geer, Elizabeth, additional, Chan, James H H, additional, Clément, Benjamin, additional, Diego, José M, additional, Gentile, Fabrizio, additional, González, Jimena, additional, Joseph, Rémy, additional, Mastache, Jorge, additional, Schuldt, Stefan, additional, Tortora, Crescenzo, additional, Verdugo, Tomás, additional, Verma, Aprajita, additional, Daylan, Tansu, additional, Millon, Martin, additional, Jackson, Neal, additional, Dye, Simon, additional, Melo, Alejandra, additional, Mahler, Guillaume, additional, Ogando, Ricardo L C, additional, Courbin, Frédéric, additional, Fritz, Alexander, additional, Herle, Aniruddh, additional, Acevedo Barroso, Javier A, additional, Cañameras, Raoul, additional, Cornen, Claude, additional, Dhanasingham, Birendra, additional, Glazebrook, Karl, additional, Martinez, Michael N, additional, Ryczanowski, Dan, additional, Savary, Elodie, additional, Góis-Silva, Filipe, additional, Arturo Ureña-López, L, additional, Wiesner, Matthew P, additional, Wilde, Joshua, additional, Valim Calçada, Gabriel, additional, Cabanac, Rémi, additional, Pan, Yue, additional, Sierra, Isaac, additional, Despali, Giulia, additional, Cavalcante-Gomes, Micaele V, additional, Macmillan, Christine, additional, Maresca, Jacob, additional, Grudskaia, Aleksandra, additional, O’Donnell, Jackson H, additional, Paic, Eric, additional, Niemiec, Anna, additional, de la Bella, Lucia F, additional, Bromley, Jane, additional, Williams, Devon M, additional, More, Anupreeta, additional, and Levine., Benjamin C, additional
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- 2023
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27. 10th antibody industrial symposium: new developments in antibody and adoptive cell therapies
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Antunes, Ana, primary, Alvarez-Vallina, Luis, additional, Bertoglio, Federico, additional, Bouquin, Nicolas, additional, Cornen, Stéphanie, additional, Duffieux, Francis, additional, Ferré, Pierre, additional, Gillet, Raphaëlle, additional, Jorgensen, Christian, additional, Leick, Mark B, additional, Maillère, Bernard, additional, Negre, Hélène, additional, Pelegrin, Mireia, additional, Poirier, Nicolas, additional, Reusch, Dietmar, additional, Robert, Bruno, additional, Serre, Guy, additional, Vicari, Alain, additional, Villalba, Martin, additional, Volpers, Christoph, additional, Vuddamalay, Gavin, additional, Watier, Hervé, additional, Wurch, Thierry, additional, Zabeau, Lennart, additional, Zielonka, Stefan, additional, Zhang, Baolin, additional, Beck, Alain, additional, and Martineau, Pierre, additional
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- 2023
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28. Characterization of the martensitic transformation in the superelastic Ti–24Nb–4Zr–8Sn alloy by in situ synchrotron X-ray diffraction and dynamic mechanical analysis
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Yang, Y., Castany, P., Cornen, M., Prima, F., Li, S.J., Hao, Y.L., and Gloriant, T.
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- 2015
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29. Micra AV leadless pacemaker implantation after transcatheter aortic valve implantation
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Alexis Mechulan, Sébastien Prevot, Angélique Peret, Lyassine Nait‐Saidi, Ichem Miliani, Lauriane Leong‐Feng, Elisabeth Leude‐Vaillant, Alain Vaillant, Alain Cornen, Bernard Latiere, Marie‐Paule Giacomoni, Frédéric Collet, Vincent Bechet, Ahmed Bouharaoua, and Pierre Dieuzaide
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Transcatheter Aortic Valve Replacement ,Pacemaker, Artificial ,Treatment Outcome ,Aortic Valve ,Bundle-Branch Block ,Cardiac Pacing, Artificial ,Humans ,General Medicine ,Atrioventricular Block ,Cardiology and Cardiovascular Medicine - Abstract
Transvenous pacemaker (PM) implantation is a complication in patients undergoing transcatheter aortic valve implantation (TAVI). Recently, a second generation of leadless PMs able of atrioventricular (AV) synchronous pacing has been introduced and could be an alternative when ventricular pacing is required after TAVI. Real-world data on Micra AV after TAVI are still lacking. Our aim was to determine the per- and post-procedural outcomes in patients with Micra AV leadless PM implantation after TAVI.A total of 20 consecutive patients underwent Micra AV leadless PM implantation after TAVI between November 2020 and June 2021.The main indication for ventricular pacing was high-degree AV block (55% of patients) and left bundle branch block (LBBB) associated with prolonged HV interval (45% of patients). At discharge, mean (SD) ventricular pacing threshold was 0.397 ± 0.11 V at 0.24 ms and ventricular impedance was 709.4 ± 139.1 Ω. At 1-month follow-up, 95% of patients were programmed in VDD pacing mode. Mean (SD) ventricular pacing threshold was 0.448 ± 0.094 V at 0.24 ms. In patients with ventriculargt; pacing gt; 90% (n = 5), mean AM-VP was 72.5% ± 8.3%. Pacing threshold at 1 month was not significantly different compared to discharge (p = .1088). Mean (SD) impedance was 631.0 ± 111.9 Ω, which remained stable at discharge (p = .0813). No procedural complications occurred during implantation. At 1-month follow-up, two patients displayed atrial under-sensing.Micra AV leadless PM implantation after TAVI is associated with a low complication rate and good device performance at 1-month post-implantation.
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- 2022
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30. Deficiency of the minor spliceosome component U4atac snRNA secondarily results in ciliary defects in human and zebrafish
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Deepak Khatri, Audrey Putoux, Audric Cologne, Sophie Kaltenbach, Alicia Besson, Eloïse Bertiaux, Justine Guguin, Adèle Fendler, Marie A. Dupont, Clara Benoit-Pilven, Leila Qebibo, Samira Ahmed-Elie, Séverine Audebert-Bellanger, Pierre Blanc, Thomas Rambaud, Martin Castelle, Gaëlle Cornen, Sarah Grotto, Agnès Guët, Laurent Guibaud, Caroline Michot, Sylvie Odent, Lyse Ruaud, Elise Sacaze, Virginie Hamel, Rémy Bordonné, Anne-Louise Leutenegger, Patrick Edery, Lydie Burglen, Tania Attié-Bitach, Sylvie Mazoyer, Marion Delous, Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hospices Civils de Lyon (HCL), Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université de Genève = University of Geneva (UNIGE), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université (SU), Hôpital Morvan [Brest], CH Morlaix, Maternité Port-Royal [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Hôpital Louis Mourier - AP-HP [Colombes], Université de Lyon, Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), CHU Pontchaillou [Rennes], Maladies neurodéveloppementales et neurovasculaires (NeuroDiderot (UMR_S_1141 / U1141)), Hôpital Robert Debré, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), This work was supported by CNRS, Inserm, Université de Montpellier, Université Paris 7 and Université Lyon 1 through recurrent funding, the Fondation Maladies Rares ('Small Animal Models and Rare Diseases' program, no. 20161207), the Agence Nationale de la Recherche (no. ANR-18CE12-0007-01), and the Fondation pour la recherche sur le Cerveau « Espoir en tête » (confocal microscope). E.B. was supported by an European Molecular Biology Organization long-term fellowship (ALTF-284-2019) and the Novartis Foundation for medical-biological Research (18B112)., and ANR-18-CE12-0007,U4ATAC-BRAIN,Rôle de l'épissage mineur dans le développement cérébral(2018)
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minor introns ,[SDV.GEN]Life Sciences [q-bio]/Genetics ,Multidisciplinary ,MESH: Humans ,MESH: Mutation ,MESH: Fetal Growth Retardation ,MESH: RNA, Small Nuclear ,U4atac ,splicing ,genetic disease ,MESH: Ciliopathies ,MESH: Animals ,MESH: Zebrafish ,MESH: Female ,MESH: Spliceosomes ,primary cilium - Abstract
In the human genome, about 750 genes contain one intron excised by the minor spliceosome. This spliceosome comprises its own set of snRNAs, among which U4atac. Its noncoding gene, RNU4ATAC , has been found mutated in Taybi-Linder (TALS/microcephalic osteodysplastic primordial dwarfism type 1), Roifman (RFMN), and Lowry-Wood (LWS) syndromes. These rare developmental disorders, whose physiopathological mechanisms remain unsolved, associate ante- and post-natal growth retardation, microcephaly, skeletal dysplasia, intellectual disability, retinal dystrophy, and immunodeficiency. Here, we report bi-allelic RNU4ATAC mutations in five patients presenting with traits suggestive of the Joubert syndrome (JBTS), a well-characterized ciliopathy. These patients also present with traits typical of TALS/RFMN/LWS, thus widening the clinical spectrum of RNU4ATAC -associated disorders and indicating ciliary dysfunction as a mechanism downstream of minor splicing defects. Intriguingly, all five patients carry the n.16G>A mutation, in the Stem II domain, either at the homozygous or compound heterozygous state. A gene ontology term enrichment analysis on minor intron-containing genes reveals that the cilium assembly process is over-represented, with no less than 86 cilium-related genes containing at least one minor intron, among which there are 23 ciliopathy-related genes. The link between RNU4ATAC mutations and ciliopathy traits is supported by alterations of primary cilium function in TALS and JBTS-like patient fibroblasts, as well as by u4atac zebrafish model, which exhibits ciliopathy-related phenotypes and ciliary defects. These phenotypes could be rescued by WT but not by pathogenic variants-carrying human U4atac. Altogether, our data indicate that alteration of cilium biogenesis is part of the physiopathological mechanisms of TALS/RFMN/LWS, secondarily to defects of minor intron splicing.
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- 2023
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31. Deficiency of the minor spliceosome component U4atac snRNA secondarily results in ciliary defects in human and zebrafish
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Khatri, Deepak, primary, Putoux, Audrey, additional, Cologne, Audric, additional, Kaltenbach, Sophie, additional, Besson, Alicia, additional, Bertiaux, Eloïse, additional, Guguin, Justine, additional, Fendler, Adèle, additional, Dupont, Marie A., additional, Benoit-Pilven, Clara, additional, Qebibo, Leila, additional, Ahmed-Elie, Samira, additional, Audebert-Bellanger, Séverine, additional, Blanc, Pierre, additional, Rambaud, Thomas, additional, Castelle, Martin, additional, Cornen, Gaëlle, additional, Grotto, Sarah, additional, Guët, Agnès, additional, Guibaud, Laurent, additional, Michot, Caroline, additional, Odent, Sylvie, additional, Ruaud, Lyse, additional, Sacaze, Elise, additional, Hamel, Virginie, additional, Bordonné, Rémy, additional, Leutenegger, Anne-Louise, additional, Edery, Patrick, additional, Burglen, Lydie, additional, Attié-Bitach, Tania, additional, Mazoyer, Sylvie, additional, and Delous, Marion, additional
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- 2023
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32. Micra AV Leadless pacemaker implantation after transcatheter aortic valve implantation
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Mechulan, A., primary, Prevot, S., additional, Peret, A., additional, Nait-Saidi, L., additional, Miliani, I., additional, Leong-Feng, L., additional, Leude-Vaillant, E., additional, Vaillant, A., additional, Cornen, A., additional, Latiere, B., additional, Giacomoni, M.P., additional, Collet, F., additional, Bechet, V., additional, Bouharaoua, A., additional, and Dieuzaide, P., additional
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- 2023
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33. Determination of hardness and elastic modulus inverse pole figures of a polycrystalline commercially pure titanium by coupling nanoindentation and EBSD techniques
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Fizanne-Michel, C., Cornen, M., Castany, P., Péron, I., and Gloriant, T.
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- 2014
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34. Texture investigation of the superelastic Ti–24Nb–4Zr–8Sn alloy
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Yang, Y., Castany, P., Cornen, M., Thibon, I., Prima, F., and Gloriant, T.
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- 2014
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35. Identification of altered cell signaling pathways using proteomic profiling in stable and progressive chronic lymphocytic leukemia
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Christelle Le Dantec, Cristina Adela Iuga, Ioana-Ecaterina Pralea, Melanie Cornen, Wesley H. Brooks, Jacques-Olivier Pers, Hussam Saad, Tiffany Bergot, Adrian Tempescul, Anne Bordron, Delphine G. Bernard, Jean-Christophe Ianotto, Cristina Bagacean, Mihnea Zdrenghea, Christian Berthou, Yves Renaudineau, Lymphocytes B, Autoimmunité et Immunothérapies (LBAI), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-LabEX IGO Immunothérapie Grand Ouest, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), CHRU Brest - Service d'Hématologie (CHU-Brest-Hemato), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Technical University of Cluj-Napoca, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) (GGB), EFS-Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), University of South Florida [Tampa] (USF), Iuliu Hatieganu University of Medicine & Pharmacy, The authors express thanks to the 'Ligue contre le cancer,' 'Region Bretagne,' sections 29/35/49 for partially funding this study, and Touzanné, Gisèle
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Male ,MESH: Leukemia, Lymphocytic, Chronic, B-Cell / genetics ,Proteome ,[SDV]Life Sciences [q-bio] ,Chronic lymphocytic leukemia ,Disease ,Stable Disease ,hemic and lymphatic diseases ,Immunology and Allergy ,Longitudinal Studies ,RNA-Seq ,liquid chromatography-tandem mass spectrometry ,MESH: Leukemia, Lymphocytic, Chronic, B-Cell / pathology ,MESH: Longitudinal Studies ,Wnt Signaling Pathway ,B-Lymphocytes ,MESH: Middle Aged ,Wnt signaling pathway ,MESH: Follow-Up Studies ,MESH: Gene Expression Regulation, Neoplastic ,Middle Aged ,Cell cycle ,Prognosis ,Gene Expression Regulation, Neoplastic ,[SDV] Life Sciences [q-bio] ,MESH: B-Lymphocytes / metabolism ,RNA splicing ,[SDV.IMM]Life Sciences [q-bio]/Immunology ,Female ,cell cycle ,[SDV.IMM] Life Sciences [q-bio]/Immunology ,RNA Splicing ,Immunology ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,splicing ,Biology ,MESH: Prognosis ,MESH: Leukemia, Lymphocytic, Chronic, B-Cell / metabolism ,MESH: Biomarkers, Tumor / genetics ,[SDV.CAN] Life Sciences [q-bio]/Cancer ,Biomarkers, Tumor ,medicine ,Humans ,Aged ,Retrospective Studies ,Proteomic Profile ,Proteomic Profiling ,Cell Biology ,MESH: B-Lymphocytes / pathology ,medicine.disease ,Leukemia, Lymphocytic, Chronic, B-Cell ,MESH: Male ,Cancer research ,chronic lymphocytic leukemia ,MESH: Female ,Follow-Up Studies - Abstract
Chronic lymphocytic leukemia (CLL) is characterized by significant biologic and clinical heterogeneity. This study was designed to explore CLL B-cells’ proteomic profile in order to identify biologic processes affected at an early stage and during disease evolution as stable or progressive. Purified B cells from 11 untreated CLL patients were tested at two time points by liquid chromatography–tandem mass spectrometry. Patients included in the study evolved to either progressive (n = 6) or stable disease (n = 5). First, at an early stage of the disease (Binet stage A), based on the relative abundance levels of 389 differentially expressed proteins (DEPs), samples were separated into stable and progressive clusters with the main differentiating factor being the RNA splicing pathway. Next, in order to test how the DEPs affect RNA splicing, a RNA-Seq study was conducted showing 4217 differentially spliced genes between the two clusters. Distinct longitudinal evolutions were observed with predominantly proteomic modifications in the stable CLL group and spliced genes in the progressive CLL group. Splicing events were shown to be six times more frequent in the progressive CLL group. The main aberrant biologic processes controlled by DEPs and spliced genes in the progressive group were cytoskeletal organization, Wnt/β-catenin signaling, and mitochondrial and inositol phosphate metabolism with a downstream impact on CLL B-cell survival and migration. This study suggests that proteomic profiles at the early stage of CLL can discriminate progressive from stable disease and that RNA splicing dysregulation underlies CLL evolution, which opens new perspectives in terms of biomarkers and therapy.
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- 2021
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36. Hubble Asteroid Hunter
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Garvin, Emily O., primary, Kruk, Sandor, additional, Cornen, Claude, additional, Bhatawdekar, Rachana, additional, Cañameras, Raoul, additional, and Merín, Bruno, additional
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- 2022
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37. Antitumor immunity induced by antibody-based natural killer cell engager therapeutics armed with not-alpha IL-2 variant
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Demaria, Olivier, primary, Gauthier, Laurent, additional, Vetizou, Marie, additional, Blanchard Alvarez, Audrey, additional, Vagne, Constance, additional, Habif, Guillaume, additional, Batista, Luciana, additional, Baron, William, additional, Belaïd, Nourhène, additional, Girard-Madoux, Mathilde, additional, Cesari, Cedric, additional, Caratini, Melody, additional, Bosco, Frédéric, additional, Benac, Olivier, additional, Lopez, Julie, additional, Fenis, Aurore, additional, Galluso, Justine, additional, Trichard, Sylvia, additional, Carrette, Barbara, additional, Carrette, Florent, additional, Maguer, Aurélie, additional, Jaubert, Solène, additional, Sansaloni, Audrey, additional, Letay-Drouet, Robin, additional, Kosthowa, Camille, additional, Lovera, Naouel, additional, Dujardin, Arnaud, additional, Chanuc, Fabien, additional, Le Van, Mélanie, additional, Bokobza, Sivan, additional, Jarmuzynski, Nicolas, additional, Fos, Camille, additional, Gourdin, Nicolas, additional, Remark, Romain, additional, Lechevallier, Eric, additional, Fakhry, Nicolas, additional, Salas, Sébastien, additional, Deville, Jean-Laurent, additional, Le Grand, Roger, additional, Bonnafous, Cécile, additional, Vollmy, Lukas, additional, Represa, Agnès, additional, Carpentier, Sabrina, additional, Rossi, Benjamin, additional, Morel, Ariane, additional, Cornen, Stéphanie, additional, Perrot, Ivan, additional, Morel, Yannis, additional, and Vivier, Eric, additional
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- 2022
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38. Design of a nitrogen-implanted titanium-based superelastic alloy with optimized properties for biomedical applications
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Gordin, D.M., Busardo, D., Cimpean, A., Vasilescu, C., Höche, D., Drob, S.I., Mitran, V., Cornen, M., and Gloriant, T.
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- 2013
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39. Cholécystite acalculeuse aiguë révélatrice de mononucléose infectieuse chez une adolescente de 12-ans. À propos d’une observation
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S. Kayemba-Kay's, A.E. Bogdan, A. Brasseur, G. Cornen, E. Lobligeois, F. Bian, and G. Pogu
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03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,030220 oncology & carcinogenesis ,Pediatrics, Perinatology and Child Health - Abstract
Resume La mononucleose infectieuse (MNI) est courante dans la population pediatrique. Sa presentation clinique est souvent stereotypee chez les enfants plus âges et les adolescents, avec une symptomatologie faite de fievre (moderee a elevee), de maux de gorge, de fatigue et de lymphadenopathie. Biologiquement, la lymphocytose ainsi qu’une legere augmentation des tests hepatiques sont habituelles. Nous rapportons un cas de cholecystite acalculeuse aigue comme presentation initiale de la MNI chez une adolescente de 12 ans dont les principales plaintes etaient des douleurs abdominales hautes et de la fievre. Le diagnostic a ete confirme par la serologie positive du virus d’Epstein-Barr et l’apparence typique de la vesicule biliaire a l’echographie abdominale. Nous rappelons aux cliniciens l’existence de cette association qui, selon nous, est probablement plus frequente qu’on ne le pensait auparavant. L’evolution clinique de notre patiente a ete spontanement favorable sous traitement symptomatique seul.
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- 2021
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40. Targeting MICA/B with cytotoxic therapeutic antibodies leads to tumor control [version 2; peer review: 2 approved]
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Mathieu Bléry, Manel Mrabet-Kraiem, Ariane Morel, Florence Lhospice, Delphine Bregeon, Cécile Bonnafous, Laurent Gauthier, Benjamin Rossi, Romain Remark, Stéphanie Cornen, Nadia Anceriz, Nicolas Viaud, Sylvia Trichard, Sabrina Carpentier, Alix Joulin-Giet, Gwendoline Grondin, Veronika Liptakova, Younghoon Kim, Laurent Daniel, Aurélie Haffner, Nicolas Macagno, Laurent Pouyet, Ivan Perrot, Carine Paturel, Yannis Morel, Alexander Steinle, François Romagné, Emilie Narni-Mancinelli, and Eric Vivier
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stomatognathic diseases ,Science ,Social Sciences - Abstract
Background: MICA and MICB are tightly regulated stress-induced proteins that trigger the immune system by binding to the activating receptor NKG2D on cytotoxic lymphocytes. MICA and MICB are highly polymorphic molecules with prevalent expression on several types of solid tumors and limited expression in normal/healthy tissues, making them attractive targets for therapeutic intervention. Methods: We have generated a series of anti-MICA and MICB cross-reactive antibodies with the unique feature of binding to the most prevalent isoforms of both these molecules. Results: The anti-MICA and MICB antibody MICAB1, a human IgG1 Fc-engineered monoclonal antibody (mAb), displayed potent antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) of MICA/B-expressing tumor cells in vitro. However, it showed insufficient efficiency against solid tumors in vivo, which prompted the development of antibody-drug conjugates (ADC). Indeed, optimal tumor control was achieved with MICAB1-ADC format in several solid tumor models, including patient-derived xenografts (PDX) and carcinogen-induced tumors in immunocompetent MICAgen transgenic mice. Conclusions: These data indicate that MICA and MICB are promising targets for cytotoxic immunotherapy.
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- 2022
41. Publisher Correction: Harnessing innate immunity in cancer therapy
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Demaria, Olivier, Cornen, Stéphanie, Daëron, Marc, Morel, Yannis, Medzhitov, Ruslan, and Vivier, Eric
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- 2019
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42. Integrated Genomic Analysis of Breast Cancers
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Chaffanet Max, Addou-Klouche L, Adélaïde J, Cornen S, Bekhouche I, Finetti P, Guille A, Sircoulomb F, Raynaud S, Bertucci F, and Birnbaum D
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breast cancers ,genome ,transcriptome ,epigenome ,oncogenes ,tumor suppressor genes ,Genetics ,QH426-470 - Abstract
Breast cancer is the most frequent and the most deadly cancer in women in Western countries. Different classifications of disease (anatomoclinical, pathological, prognostic, genetic) are used for guiding the management of patients. Unfortunately, they fail to reflect the whole clinical heterogeneity of the disease. Consequently, molecularly distinct diseases are grouped in similar clinical classes, likely explaining the different clinical outcome between patients in a given class, and the fact that selection of the most appropriate diagnostic or therapeutic strategy for each patient is not done accurately. Today, treatment is efficient in only 70.0- 75.0% of cases overall. Our repertoire of efficient drugs is limited but is being expanded with the discovery of new molecular targets for new drugs, based on the identification of candidate oncogenes and tumor suppressor genes (TSG) functionally relevant in disease. Development of new drugs makes therapeutical decisions even more demanding of reliable classifiers and prognostic/predictive tests. Breast cancer is a complex, heterogeneous disease at the molecular level. The combinatorial molecular origin and the heterogeneity of malignant cells, and the variability of the host background, create distinct subgroups of tumors endowed with different phenotypic features such as response to therapy and clinical outcome. Cellular and molecular analyses can identify new classes biologically and clinically relevant, as well as provide new clinically relevant markers and targets.
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- 2012
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43. Micra AV leadless pacemaker implantation after transcatheter aortic valve implantation
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Mechulan, Alexis, primary, Prevot, Sébastien, additional, Peret, Angélique, additional, Nait‐Saidi, Lyassine, additional, Miliani, Ichem, additional, Leong‐Feng, Lauriane, additional, Leude‐Vaillant, Elisabeth, additional, Vaillant, Alain, additional, Cornen, Alain, additional, Latiere, Bernard, additional, Giacomoni, Marie‐Paule, additional, Collet, Frédéric, additional, Bechet, Vincent, additional, Bouharaoua, Ahmed, additional, and Dieuzaide, Pierre, additional
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- 2022
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44. Hubble Asteroid Hunter: II. Identifying strong gravitational lenses in HST images with crowdsourcing
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Emily O. Garvin, Sandor Kruk, Claude Cornen, Rachana Bhatawdekar, Raoul Cañameras, and Bruno Merín
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Cosmology and Nongalactic Astrophysics (astro-ph.CO) ,Gravitational lensing ,FOS: Physical sciences ,Astronomy and Astrophysics ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Strong – catalogs – galaxies ,Astrophysics - Astrophysics of Galaxies ,Space and Planetary Science ,Astrophysics of Galaxies (astro-ph.GA) ,Physics::Space Physics ,Astrophysics::Earth and Planetary Astrophysics ,General ,Astrophysics::Galaxy Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
Context. The Hubble Space Telescope (HST) archives constitute a rich dataset of high-resolution images to mine for strong gravitational lenses. While many HST programmes specifically target strong lenses, they can also be present by coincidence in other HST observations. Aims. Our aim is to identify non-Targeted strong gravitational lenses, without any prior selection on the lens properties, in almost two decades of images from the ESA HST archive (eHST). Methods. We used crowdsourcing on the Hubble Asteroid Hunter (HAH) citizen science project to identify strong lenses, along with asteroid trails, in publicly available large field-of-view HST images. We visually inspected 2354 objects tagged by citizen scientists as strong lenses to clean the sample and identify the genuine lenses. Results. We report the detection of 252 strong gravitational lens candidates, which were not the primary targets of the HST observations. A total of 198 of them are new, not previously reported by other studies, consisting of 45 A grades, 74 B grades and 79 C grades. The majority are galaxy-galaxy configurations. The newly detected lenses are, on average, 1.3 magnitudes fainter than previous HST searches. This sample of strong lenses with high-resolution HST imaging is ideal to follow up with spectroscopy for lens modelling and scientific analyses. Conclusions. This paper presents the unbiased search of lenses that enabled us to find a wide variety of lens configurations, including exotic lenses. We demonstrate the power of crowdsourcing in visually identifying strong lenses and the benefits of exploring large archival datasets. This study shows the potential of using crowdsourcing in combination with artificial intelligence for the detection and validation of strong lenses in future large-scale surveys such as ESA's Euclid mission or in James Webb Space Telescope (JWST) archival images., Astronomy & Astrophysics, 667, ISSN:0004-6361, ISSN:1432-0746
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- 2022
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45. U–Mo/Al–Si interaction: Influence of Si concentration
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Allenou, J., Palancher, H., Iltis, X., Cornen, M., Tougait, O., Tucoulou, R., Welcomme, E., Martin, Ph., Valot, C., Charollais, F., Anselmet, M.C., and Lemoine, P.
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- 2010
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46. Neutron diffraction analyses of U–(6–10 wt.%)Mo alloy powders fabricated by centrifugal atomization
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Park, Jong Man, Ryu, Ho Jin, Kim, Ki Hwan, Lee, Don Bae, Lee, Yoon Sang, Lee, Jeong Soo, Seong, Baek Seok, Kim, Chang Kyu, and Cornen, Marilyne
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- 2010
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47. Antitumor immunity induced by antibody-based natural killer cell engager therapeutics armed with not-alpha IL-2 variant
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Olivier Demaria, Laurent Gauthier, Marie Vetizou, Audrey Blanchard Alvarez, Constance Vagne, Guillaume Habif, Luciana Batista, William Baron, Nourhène Belaïd, Mathilde Girard-Madoux, Cedric Cesari, Melody Caratini, Frédéric Bosco, Olivier Benac, Julie Lopez, Aurore Fenis, Justine Galluso, Sylvia Trichard, Barbara Carrette, Florent Carrette, Aurélie Maguer, Solène Jaubert, Audrey Sansaloni, Robin Letay-Drouet, Camille Kosthowa, Naouel Lovera, Arnaud Dujardin, Fabien Chanuc, Mélanie Le Van, Sivan Bokobza, Nicolas Jarmuzynski, Camille Fos, Nicolas Gourdin, Romain Remark, Eric Lechevallier, Nicolas Fakhry, Sébastien Salas, Jean-Laurent Deville, Roger Le Grand, Cécile Bonnafous, Lukas Vollmy, Agnès Represa, Sabrina Carpentier, Benjamin Rossi, Ariane Morel, Stéphanie Cornen, Ivan Perrot, Yannis Morel, Eric Vivier, Innate Pharma, Recherche & Développement, Immunologie des tumeurs et immunothérapie (UMR 1015), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Aix-Marseille Université - École de médecine (AMU SMPM MED), Aix-Marseille Université - Faculté des sciences médicales et paramédicales (AMU SMPM), Aix Marseille Université (AMU)-Aix Marseille Université (AMU), Institut Cochin (UMR_S567 / UMR 8104), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Méthodes computationnelles pour la prise en charge thérapeutique en oncologie : Optimisation des stratégies par modélisation mécaniste et statistique (COMPO), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Assistance Publique - Hôpitaux de Marseille (APHM)
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MESH: Killer Cells, Natural ,MESH: Cytokines ,Cancer immunotherapy ,MESH: Interleukin-2 ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,Receptors, Interleukin-2 ,MESH: Chemokines ,General Biochemistry, Genetics and Molecular Biology ,MESH: Receptors, Interleukin-2 ,Killer Cells, Natural ,Natural Killer cells ,Neoplasms ,cytokine ,Animals ,Interleukin-2 ,Cytokines ,MESH: Neoplasms ,multispecific antibodies ,Chemokines - Abstract
International audience; Harnessing innate immunity is emerging as a promising therapeutic approach in cancer. We report here the design of tetraspecific molecules engaging natural killer (NK) cell-activating receptors NKp46 and CD16a, the β-chain of the interleukin-2 receptor (IL-2R), and a tumor-associated antigen (TAA). In vitro, these tetraspecific antibody-based natural killer cell engager therapeutics (ANKETs) induce a preferential activation and proliferation of NK cells, and the binding to the targeted TAA triggers NK cell cytotoxicity and cytokine and chemokine production. In vivo, tetraspecific ANKETs induce NK cell proliferation and their accumulation at the tumor bed, as well as the control of local and disseminated tumors. Treatment of non-human primates with CD20-directed tetraspecific ANKET leads to CD20+ circulating B cell depletion, with minimal systemic cytokine release and no sign of toxicity. Tetraspecific ANKETs, thus, constitute a technological platform for harnessing NK cells as next-generation cancer immunotherapies.
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- 2021
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48. An Industry Perspective on Forced Degradation Studies of Biopharmaceuticals: Survey Outcome and Recommendations
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Wasfi Al-Azzam, Sambit R. Kar, Niclas Chiang Tan, Zhenyu Gu, Zoran Sosic, Crystal Cicchino, Alexandru C. Lazar, Paul Weisbach, Yite Robert Chou, Liqiang Lisa Zhou, Jennifer Halley, Santosh V. Thakkar, Smith John M, Magdalena Gauden, Elaine S.E. Stokes, Min Huang, Promod Mehndiratta, Vikas K. Sharma, and Stephane Cornen
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Process management ,Drug Industry ,Computer science ,Chemistry, Pharmaceutical ,media_common.quotation_subject ,Control (management) ,Pharmaceutical Science ,02 engineering and technology ,030226 pharmacology & pharmacy ,Outcome (game theory) ,03 medical and health sciences ,Consistency (database systems) ,0302 clinical medicine ,Product lifecycle ,Drug Development ,Surveys and Questionnaires ,Freezing ,Humans ,Quality (business) ,media_common ,Biological Products ,Comparability ,Antibodies, Monoclonal ,Benchmarking ,021001 nanoscience & nanotechnology ,Product (business) ,Oxidative Stress ,0210 nano-technology - Abstract
The BioPhorum Development Group is an industry-wide consortium enabling networking and sharing of common practices for the development of biopharmaceuticals. Forced degradation studies (FDSs) are often used in biotherapeutic development to assess criticality of quality attributes and in comparability studies to ensure product manufacturing process consistency. To gain an understanding of current industry approaches for FDS, the BioPhorum Development Group-Forced Degradation Point Share group conducted an intercompany collaboration exercise, which included a benchmarking survey and group discussions around FDS of monoclonal antibodies. The results of this industry collaboration provide insights into the practicalities of these characterization studies and how they are being used to support the product lifecycle from innovation to marketed products. The survey requested feedback on the intended purpose, materials, conditions, number and length of time points used, and analytical techniques carried out to give a complete picture of the range of common industry practices. This article discusses the results of this global benchmarking survey across 12 companies and presents these as a guide to a common approach to FDS across the industry which can be used to guide the design of FDS based on chemistry and manufacturing control product life-cycle and biomolecule needs.
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- 2020
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49. 123MO Monalizumab, cetuximab and durvalumab in first-line treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN): A phase II trial
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Colevas, D.A., primary, Misiukiewicz, K., additional, Pearson, A.T., additional, Fayette, J., additional, Bauman, J.R., additional, Cupissol, D., additional, Saada-Bouzid, E., additional, Adkins, D.R., additional, Marie, D.B., additional, Cornen, S.L., additional, André, P., additional, Carrette, F., additional, Rotolo, F., additional, Boyer Chammard, A., additional, and Cohen, R.B., additional
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- 2021
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50. 851 Harnessing innate immunity in cancer therapies: the example of natural killer cell engagers
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Demaria, Olivier, primary, Vivier, Eric, additional, Vetizou, Marie, additional, Alvarez, Audrey Blanchard, additional, Habif, Guillaume, additional, Bonnafous, Cécile, additional, Bokobza, Sivan, additional, Represa, Agnès, additional, Rossi, Benjamin, additional, Batista, Luciana, additional, Vagne, Constance, additional, Carpentier, Sabrina, additional, Cornen, Stéphanie, additional, Morel, Ariane, additional, Perrot, Ivan, additional, Morel, Yannis, additional, and Gauthier, Laurent, additional
- Published
- 2021
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