162 results on '"A, Grünewaldt"'
Search Results
2. Primary Ciliary Dyskinesia in Adult Bronchiectasis: Data from the German Bronchiectasis Registry PROGNOSIS
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Grün, Borghild, Windsheim, Bad, Dargel, Stefan, Ludwig, Katarina, Roux, Andrés de, Otto-Knapp, Ralf, Lode, Hartmut, Gogoll, Christian, Probst, Meike, Herrmann, Frank, Overlack, Axel, Pabst, Stefan, Sommerwerck, Urte, Vehar, Köln; Harald, Blaas, Stefan, Schaaf, Bernhard, Kolditz, Martin, Sutharsan, Sivagurunathan, Kardos, Essen; Peter, Grünewaldt, Achim, Sorichter, Stephan, Scholz, Tobias, Idzko, Marco, Mohadjer, Moritz, Eisenmann, Stephan, Aries, Sven P., Lauer-Hermfisse, Johannes, Kampf, Sabine, Ringshausen, Felix C., Wege, Sabine, Herth, Felix, Ewig, Santiago, Reinhardt, Christian, Andreas, Stefan, Schumann, Christian, Bobis, Ingrid, Bahmer, Thomas, Fey, Kiel; Rita, Jüch, Martin, Kempa, Lostau; Axel T., Piirsoo, Erika, Klapdor, Benjamin, Mertsch, Pontus, Schmidt, Bernhard, Hein, Holger, Haidl, Peter, Gamarra, Jorge Fernando, Ewen, Raphael, Pink, Isabell, Shoemark, Amelia, Staar, Ben O., and Rademacher, Jessica
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- 2024
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3. Aspergillus Serologic Findings and Clinical Outcomes in Patients With Bronchiectasis: Data From the European Bronchiectasis Registry
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Pollock, J., Goeminne, P.C., Aliberti, S., Polverino, E., Crichton, M.L., Ringshausen, F.C., Dhar, R., Vendrell, M., Burgel, P.R., Haworth, C.S., De Soyza, A., De Gracia, J., Bossios, A., Rademacher, J., Grünewaldt, A., McDonnell, M., Stolz, D., Sibila, O., van der Eerden, M., Kauppi, P., Hill, A.T., Wilson, R., Amorim, A., Munteanu, O., Menendez, R., Torres, A., Welte, T., Blasi, F., Boersma, W., Elborn, J.S., Shteinberg, M., Dimakou, K., Chalmers, James D., and Loebinger, M.R.
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- 2024
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4. Primary Ciliary Dyskinesia in Adult Bronchiectasis
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Ewen, Raphael, Pink, Isabell, Sutharsan, Sivagurunathan, Aries, Sven P., Grünewaldt, Achim, Shoemark, Amelia, Sommerwerck, Urte, Staar, Ben O., Wege, Sabine, Mertsch, Pontus, Rademacher, Jessica, Ringshausen, Felix C., Grün, Borghild, Windsheim, Bad, Dargel, Stefan, Ludwig, Katarina, Roux, Andrés de, Otto-Knapp, Ralf, Lode, Hartmut, Gogoll, Christian, Probst, Meike, Herrmann, Frank, Overlack, Axel, Pabst, Stefan, Sommerwerck, Urte, Vehar, Köln; Harald, Blaas, Stefan, Schaaf, Bernhard, Kolditz, Martin, Sutharsan, Sivagurunathan, Kardos, Essen; Peter, Grünewaldt, Achim, Sorichter, Stephan, Scholz, Tobias, Idzko, Marco, Mohadjer, Moritz, Eisenmann, Stephan, Aries, Sven P., Lauer-Hermfisse, Johannes, Kampf, Sabine, Ringshausen, Felix C., Wege, Sabine, Herth, Felix, Ewig, Santiago, Reinhardt, Christian, Andreas, Stefan, Schumann, Christian, Bobis, Ingrid, Bahmer, Thomas, Fey, Kiel; Rita, Jüch, Martin, Kempa, Lostau; Axel T., Piirsoo, Erika, Klapdor, Benjamin, Mertsch, Pontus, Schmidt, Bernhard, Hein, Holger, Haidl, Peter, and Gamarra, Jorge Fernando
- Abstract
Primary ciliary dyskinesia (PCD) is a rare genetic disorder caused by the malfunction of motile cilia and a specific etiology of adult bronchiectasis of unknown prevalence. A better understanding of the clinical phenotype of adults with PCD is needed to identify individuals for referral to diagnostic testing.
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- 2024
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5. Resurgence of common respiratory viruses in patients with community-acquired pneumonia (CAP)—A prospective multicenter study
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Dähne, Theo, primary, Bauer, Wolfgang, additional, Essig, Andreas, additional, Schaaf, Bernhard, additional, Barten-Neiner, Grit, additional, Spinner, Christoph D., additional, Pletz, Mathias W., additional, Rohde, Gernot, additional, Rupp, Jan, additional, Witzenrath, Martin, additional, Panning, Marcus, additional, Fuchs, A., additional, Engelmannn, M., additional, Stolz, D., additional, Bauer, W., additional, Mücke, H.C., additional, Suttorp, N., additional, Witzenrath, M., additional, Schmager, S., additional, Schaaf, B., additional, Kremling, J., additional, Nickoleit-Bitzenberger, D., additional, Azzaui, H., additional, Hower, M., additional, Hempel, F., additional, Prebeg, K., additional, Popkirova, K., additional, Kolditz, M., additional, Rohde, G., additional, Bellinghausen, C., additional, Grünewaldt, A., additional, Panning, M., additional, Welte, T., additional, Fühner, T., additional, van't Klooster, M., additional, Barten-Neiner, G., additional, Kröner, W., additional, Unruh, Ol., additional, Adaskina, N., additional, Eberherdt, F., additional, Julius, C., additional, Illig, T., additional, Klopp, N., additional, Pletz, M., additional, Schleenvoigt, B.T., additional, Forstner, C., additional, Moeser, A., additional, Ankert, J., additional, Drömannn, D., additional, Parschke, P., additional, Franzen, K., additional, Rupp, J., additional, Käding, N., additional, Waldeck, F., additional, Spinner, C., additional, Erber, J., additional, Voit, F., additional, Schneider, J., additional, Heigener, D., additional, Hering, I., additional, Albrich, W., additional, Seneghini, M., additional, Rassouli, F., additional, Baldesberger, S., additional, Essig, A., additional, Stenger, S., additional, Wallner, M., additional, Burgmann, H., additional, Traby, L., additional, Schubert, L., additional, and Chen, R., additional
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- 2024
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6. Characteristics, clinical course and outcome of ventilated patients at a non-surgical intensive care unit in Germany: a single-centre, retrospective observational cohort analysis
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Gernot G U Rohde, Kai-Henrik Peiffer, Achim Grünewaldt, and Jörg Bojunga
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Medicine - Abstract
Objectives The objective of this study was to evaluate epidemiological characteristics, clinical course and outcome of mechanically ventilated non-surgical intensive care unit (ICU) patients, with the aim of improving the strategic planning of ICU capacities.Design We conducted a retrospective observational cohort analysis. Data from mechanically ventilated intensive care patients were obtained by investigating electronic health records. The association between clinical parameters and ordinal scale data of clinical course was evaluated using Spearman correlation and Mann-Whitney U test. Relations between clinical parameters and in-hospital mortality rates were examined using binary logistic regression analysis.Setting A single-centre study at the non-surgical ICU of the University Hospital of Frankfurt, Germany (tertiary care-level centre).Participants All cases of critically ill adult patients in need of mechanical ventilation during the years 2013–2015 were included. In total, 932 cases were analysed.Results From a total of 932 cases, 260 patients (27.9%) were transferred from peripheral ward, 224 patients (24.1%) were hospitalised via emergency rescue services, 211 patients (22.7%) were admitted via emergency room and 236 patients (25.3%) via various transfers. In 266 cases (28.5%), respiratory failure was the reason for ICU admission. The length of stay was higher in non-geriatric patients, patients with immunosuppression and haemato-oncological disease or those in need of renal replacement therapy. 431 patients died, which corresponds to an all-cause in-hospital mortality rate of 46.2%. 92 of 172 patients with presence of immunosuppression (53.5%), 111 of 186 patients (59.7%) with pre-existing haemato-oncological disease, 27 of 36 patients (75.0%) under extracorporeal membrane oxygenation (ECMO) therapy, and 182 of 246 patients (74.0%) undergoing renal replacement therapy died. In logistic regression analysis, these subgroups and older age were significantly associated with higher mortality rates.Conclusions Respiratory failure was the main reason for ventilatory support at this non-surgical ICU. Immunosuppression, haemato-oncological diseases, the need for ECMO or renal replacement therapy and older age were associated with higher mortality.
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- 2023
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7. Comorbidity defines asthmatic patients' risk of COVID-19 hospitalization: A global perspective
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Skevaki, Chrysanthi, Chinthrajah, R. Sharon, Fomina, Daria, Rohde, Gernot, Cao, Shu, He, Ziyuan, Serdotetskova, Sofia, Seidemann, Christian, Grünewaldt, Achim, Vengadeswaran, Abisha, Xie, Min, Karsonova, Antonina, Karaulov, Alexander, Nadeau, Kari C., Chung, Ho-Ryun, and Renz, Harald
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- 2022
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8. Increased risk of respiratory events during endobronchial ultrasound examination in patients with reduced forced expiratory volume: a prospective observational study.
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Grünewaldt, Achim and Rohde, Gernot
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- 2024
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9. Nasal High-Flow Oxygen Therapy in Chronic Respiratory Failure for Homecare Applications—A Feasibility Study.
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Grünewaldt, Achim and Rohde, Gernot
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INTERSTITIAL lung diseases , *PATIENT compliance , *INTENSIVE care patients , *CYSTIC fibrosis , *RESPIRATORY insufficiency - Abstract
Background: While high-flow nasal cannulas (HFNCs) represent the standard of care in the intensive care unit for patients with severe hypoxemia, its use in homecare settings is uncommon despite its potential. The potential benefits and challenges of the high-flow nasal cannula (HFNC) in homecare settings compared to standard long-term oxygen via nasal low-flow therapy are unclear. Methods: We conducted a prospective monocentric feasibility study at the Department of Respiratory Medicine, University Hospital, Goethe University Frankfurt, Germany. Patients with interstitial lung disease or severe bronchiectasis (including cystic fibrosis) were enrolled into the study. The HFNC was introduced during hospitalization. The patients' compliance with home use advice and arterial blood gas results were evaluated at a 4–6-week follow-up. Results: A total of 12 patients were analyzed. HFNC initiation did not result in a significant improvement of the pO2/fiO2 (p/f) ratio. Only 8 out of 12 (66.6%) patients used the HFNC at home after the initial in-hospital initiation. Only 7 of the total 12 patients were using the therapy at a follow-up 3–6 weeks after HFNC onset. Two patients died during the observation, resulting in a surveillance mortality rate of 16.7%. Conclusions: The feasibility data showed low adherence to the HFNC at home. The lack of any positive effect on the p/f ratio may be due to low airflow rates and overall mild hypoxemia compared to patients with severe respiratory failure in the ICU. [ABSTRACT FROM AUTHOR]
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- 2024
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10. Letalität der ambulant erworbenen Pneumonie nicht unterschätzen!
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Grünewaldt, Achim, Hügel, Christian, Bellinghausen, Carla, and Rohde, Gernot
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- 2020
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11. BASHY Dyes Are Highly Efficient Lipid Droplet-Targeting Photosensitizers that Induce Ferroptosis through Lipid Peroxidation
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Silva, Maria J. S. A., primary, Zhang, Yiyi, additional, Vinck, Robin, additional, Santos, Fábio M. F., additional, António, João P. M., additional, Gourdon-Grünewaldt, Lisa, additional, Zaouter, Charlotte, additional, Castonguay, Annie, additional, Patten, Shunmoogum A., additional, Cariou, Kevin, additional, Boscá, Francisco, additional, Nájera, Francisco, additional, Arteaga, Jesús F., additional, Gasser, Gilles, additional, Pischel, Uwe, additional, and Gois, Pedro M. P., additional
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- 2023
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12. BASHY Dyes Are Highly Efficient Lipid Droplet-targeting Photosensitizers That Induce Ferroptosis Through Lipid Peroxidation
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Silva, Maria, primary, Zhang, Yiyi, additional, Vinck, Robin, additional, Santos, Fábio, additional, António, João, additional, Gourdon-Grünewaldt, Lisa, additional, Zaouter, Charlotte, additional, Castonguay, Annie, additional, Patten, Shunmoogum, additional, Cariou, Kevin, additional, Boscá, Francisco, additional, Nájera, Francisco, additional, Arteaga, Jesús, additional, Gasser, Gilles, additional, Pischel, Uwe, additional, and Gois, Pedro, additional
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- 2023
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13. Towards Copper(I) Clusters for Photo‐ Induced Oxidation of Biological Thiols in Living Cells
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Gourdon-Grünewaldt, Lisa, primary, Blacque, Olivier, additional, Gasser, Gilles, additional, and Cariou, Kevin, additional
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- 2023
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14. Characterisation of cardiopulmonary exercise tolerance in patients with COVID19 sequelae
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Grünewaldt, Achim, primary, Azem, Tara, additional, Bellinghausen, Carla, additional, Lask, Cornelius, additional, Hügel, Christian, additional, Seeger, Alexander, additional, Khodamoradi, Yascha, additional, Herrmann, Eva, additional, Vehreschild, Maria, additional, and Rohde, Gernot, additional
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- 2023
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15. Resurgence of common respiratory viruses in patients with community-acquired pneumonia (CAP)—A prospective multicenter study
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Fuchs, A., Engelmannn, M., Stolz, D., Bauer, W., Mücke, H.C., Suttorp, N., Witzenrath, M., Schmager, S., Schaaf, B., Kremling, J., Nickoleit-Bitzenberger, D., Azzaui, H., Hower, M., Hempel, F., Prebeg, K., Popkirova, K., Kolditz, M., Rohde, G., Bellinghausen, C., Grünewaldt, A., Panning, M., Welte, T., Fühner, T., van't Klooster, M., Barten-Neiner, G., Kröner, W., Unruh, Ol., Adaskina, N., Eberherdt, F., Julius, C., Illig, T., Klopp, N., Pletz, M., Schleenvoigt, B.T., Forstner, C., Moeser, A., Ankert, J., Drömannn, D., Parschke, P., Franzen, K., Rupp, J., Käding, N., Waldeck, F., Spinner, C., Erber, J., Voit, F., Schneider, J., Heigener, D., Hering, I., Albrich, W., Seneghini, M., Rassouli, F., Baldesberger, S., Essig, A., Stenger, S., Wallner, M., Burgmann, H., Traby, L., Schubert, L., Chen, R., Dähne, Theo, Bauer, Wolfgang, Essig, Andreas, Schaaf, Bernhard, Barten-Neiner, Grit, Spinner, Christoph D., Pletz, Mathias W., Rohde, Gernot, Rupp, Jan, Witzenrath, Martin, and Panning, Marcus
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- 2024
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16. Rhinoviren
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Grünewaldt, A., Hügel, C., and Rohde, G. G. U.
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- 2019
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17. Towards Platinum(II) Complexes forin celluloApplications: Synthesis, Characterization, Biological and Catalytic Evaluation
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Gourdon‐Grünewaldt, Lisa, primary, Bakija, Marija, additional, Wild, Lara, additional, Perić, Berislav, additional, Gasser, Gilles, additional, Kirin, Srećko I., additional, and Cariou, Kevin, additional
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- 2023
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18. Characteristics, clinical course and outcome of ventilated patients at a non-surgical intensive care unit in Germany: a single-centre, retrospective observational cohort analysis
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Grünewaldt, Achim, primary, Peiffer, Kai-Henrik, additional, Bojunga, Jörg, additional, and Rohde, Gernot G U, additional
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- 2023
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19. Towards Platinum(II) Complexes for in cellulo Applications: Synthesis, Characterization, Biological and Catalytic Evaluation
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Gourdon-Grünewaldt, Lisa, Bakija, Marija, Wild, Lara, Gasser, Gilles, Perić, Berislav, Kirin, Srećko, Cariou, Kevin, Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL), ERC Grant, and European Project: 681679, H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC),681679,PhotoMedMet(2017)
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catalysis ,silver (I) ,platinum (II) silver (I) catalysis chemical biology ,platinum (II) ,chemical biology ,[CHIM.THER]Chemical Sciences/Medicinal Chemistry - Abstract
International audience; With the aim of achieving bioorthogonal intracellular catalysis, a library of platinum(II) complexes was synthesized. Their non-toxicity to living cells was demonstrated and their catalytic activity was evaluated on a cyclization reaction leading to a highly fluorescent coumarin. None of the platinum complexes showed any catalytic activity for coumarin synthesis. Still, we demonstrated that the silver salt AgSbF6 commonly used to "activate" metal catalysts by removing a chloride is a very efficient catalyst for the studied intramolecular cyclization reaction.
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- 2023
20. Synthesis, characterisation and biological evaluation of monometallic Re( i ) and heterobimetallic Re( i )/Fe( ii ) complexes with a 1,2,3-triazolyl pyridine chelating moiety
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Jakopec, Silvio, Gourdon-Grünewaldt, Lisa, Čipor, Ivona, Meščić Macan, Andrijana, Perić, Berislav, Piantanida, Ivo, Cariou, Kevin, Gasser, Gilles, Kirin, Srećko, Raić-Malić, Silvana, Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL), ERC Grant, and European Project: 681679, H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC),681679,PhotoMedMet(2017)
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[CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry ,Bioorganometallic Chemistry ,Cancer - Abstract
International audience; Bioorganometallic complexes have attracted considerable interest and have shown promise for potential application in the treatment and diagnosis of cancer, as well as bioimaging agents, some acting as theranostic agents. The series of novel ferrocene, benzimidazo[1,2-a]quinoline and fluorescein derivatives with bidentate pyridyl-1,2,3-triazole and 2,2′-dipyridylamine and their tricarbonylrhenium(I) complexes was prepared and fully characterised by NMR, single-crystal X-ray diffraction, UV-Vis and fluorescence spectroscopy in biorelevant conditions. The fluorescein and benzimidazo[1,2-a]quinoline ligands and their complexes with Re(I) showed interactions with ds-DNA/RNA and HSA, characterised by thermal denaturation measurements, fluorimetric and circular dichroism titrations. The binding constants revealed that addition of Re(I) increases the affinity of fluorescein but decreases the affinity of benzimidazo[1,2-a]quinoline. The complexation of Re(I) had the opposite effect on fluorescein and benzimidazo[1,2-a]quinoline ligands’ fluorimetric sensitivity upon biomacromolecule binding, Re(I) fluorescein complex emission being strongly quenched by DNA/RNA or HSA, while emission of Re(I) benzimidazo[1,2-a]quinolone complex was enhanced, particularly for HSA, making it a promising fluorescent probe. Some mono- and heterobimetallic complexes showed considerable antiproliferative activity on colon cancer cells (CT26 and HT29), with ferrocene dipyridylamine complexes exhibiting the best inhibitory activity, comparable to cisplatin. The correlation of the cytotoxicity data with the linker type between the ferrocene and the 1,2,3-triazole ring suggests that direct binding of the metallocene to the 1,2,3-triazole is favourable for antitumor activity. The Re(I) benzimidazo[1,2-a]quinolone complex showed moderate antiproliferative activity, in contrast to the Re(I) fluorescein complex, which exhibited weak activity on CT26 cells and no activity on HT29 cells. The accumulation of the Re(I) benzimidazo[1,2-a]quinolone complex in the lysosomes of CT26 cells indicates the site of its bioactivity, thus making this complex a potential theranostic agent.
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- 2023
21. Serum markers of chronic inflammation and pulmonary remodelling in patients with long COVID up to one year after infection
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Bellinghausen, C, primary, Grünewaldt, A, additional, Khodamoradi, Y, additional, Du, W, additional, Azem, T, additional, Lask, C, additional, Vehreschild, M, additional, and Rohde, G, additional
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- 2023
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22. Towards Copper(I) Clusters for Photo‐Induced Oxidation of Biological Thiols in Living Cells**
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Gourdon‐Grünewaldt, Lisa, Blacque, Olivier; https://orcid.org/0000-0001-9857-4042, Gasser, Gilles; https://orcid.org/0000-0002-4244-5097, Cariou, Kevin; https://orcid.org/0000-0002-5854-9632, Gourdon‐Grünewaldt, Lisa, Blacque, Olivier; https://orcid.org/0000-0001-9857-4042, Gasser, Gilles; https://orcid.org/0000-0002-4244-5097, and Cariou, Kevin; https://orcid.org/0000-0002-5854-9632
- Abstract
The cell redox balance can be disrupted by the oxidation of biological peptides, eventually leading to cell death, which provides opportunities to develop cytotoxic drugs. With the aim of developing compounds capable of specifically inducing fatal redox reactions upon light irradiation, we have developed a library of copper compounds. This metal is abundant and considered essential for human health, making it particularly attractive for the development of new anticancer drugs. Copper(I) clusters with thiol ligands (including 5 novel ones) have been synthesized and characterized. Structures were elucidated by X‐ray diffraction and showed that the compounds are oligomeric clusters. The clusters display high photooxidation capacity towards cysteine – an essential amino acid – upon light irradiation in the visible range (450 nm), while remaining completely inactive in the dark. This photoredox activity against a biological thiol is very encouraging for the development of anticancer photoredox drugs.The in vitro assay on murine colorectal cancer cells (CT26) did not show any toxicity – whether in the dark or when exposed to 450 nm light, likely because of the poor solubility of the complexes in biological medium.
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- 2023
23. Insights on the Management and Outcomes of Patients With Progressive Fibrosing Interstitial Lung Disease in Clinical Practice: INSIGHTS-ILD Registry
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J. Behr, M. Kreuter, A. Prasse, A.U. Guenther, F. Bonella, D. Pittrow, C. Pausch, D. Skowasch, H. Wilkens, H.-J.J. Kabitz, H. Wirtz, M. Claussen, C. Grohé, L. Hagmeyer, S. Budweiser, I. Andreica, U. Neff, H. Biller, S. Glaeser, M. Schwaiblmair, P. Schramm, K. Thabaret, J. Klotsche, T. Veit, M. Frankenberger, L. Drobbe, W. Gesierich, B. Seese, A. Grünewaldt, P. Markart, M. Westhoff, M. Held, J. Kirschner, J. Wälscher, S. Eisenmann, S. Walterspacher, C. Neurohr, C.-P. Kreutz, D. Grund, S. Haberl, R. Ewert, D. Koschel, and null INSIGHTS-ILD Registry Group
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- 2023
24. Serum markers of chronic inflammation and pulmonary remodelling in patients with long COVID up to one year after infection
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C Bellinghausen, A Grünewaldt, Y Khodamoradi, W Du, T Azem, C Lask, M Vehreschild, and G Rohde
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- 2023
25. Synthesis, characterisation and biological evaluation of monometallic Re(i) and heterobimetallic Re(i)/Fe(ii) complexes with a 1,2,3-triazolyl pyridine chelating moiety
- Author
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Jakopec, Silvio, primary, Gourdon-Grünewaldt, Lisa, additional, Čipor, Ivona, additional, Meščić Macan, Andrijana, additional, Perić, Berislav, additional, Piantanida, Ivo, additional, Cariou, Kevin, additional, Gasser, Gilles, additional, Kirin, Srećko I., additional, and Raić-Malić, Silvana, additional
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- 2023
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26. Comorbidity defines asthmatic patients' risk of COVID-19 hospitalization: A global perspective
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Skevaki, Chrysanthi, primary, Chinthrajah, R. Sharon, additional, Fomina, Daria, additional, Rohde, Gernot, additional, Cao, Shu, additional, He, Ziyuan, additional, Serdotetskova, Sofia, additional, Seidemann, Christian, additional, Grünewaldt, Achim, additional, Vengadeswaran, Abisha, additional, Xie, Min, additional, Karsonova, Antonina, additional, Karaulov, Alexander, additional, Nadeau, Kari C., additional, Chung, Ho-Ryun, additional, and Renz, Harald, additional
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- 2023
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27. Hypercapnic Failure in Acute Exacerbated COPD Patients: Severe Airflow Limitation as an Early Warning Signal
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Grünewaldt, Achim, primary, Fritsch, Norbert, additional, and Rohde, Gernot, additional
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- 2022
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28. Long-term (180-day) outcomes in critically ill patients with COVID-19 in the REMAP-CAP randomized clinical trial
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Florescu, S, Stanciu, D, Zaharia, M, Kosa, A, Codreanu, D, Kidwai, A, Masood, S, Kaye, C, Coutts, A, MacKay, L, Summers, C, Polgarova, P, Farahi, N, Fox, E, McWilliam, S, Hawcutt, D, Rad, L, O’Malley, L, Whitbread, J, Jones, D, Dore, R, Saunderson, P, Kelsall, O, Cowley, N, Wild, L, Thrush, J, Wood, H, Austin, K, Bélteczki, J, Magyar, I, Fazekas, Á, Kovács, S, Szőke, V, Donnelly, A, Kelly, M, Smyth, N, O’Kane, S, McClintock, D, Warnock, M, Campbell, R, McCallion, E, Azaiz, A, Charron, C, Godement, M, Geri, G, Vieillard-Baron, A, Johnson, P, McKenna, S, Hanley, J, Currie, A, Allen, B, McGoldrick, C, McMaster, M, Mani, A, Mathew, M, Kandeepan, R, Vignesh, C, TV, B, Ramakrishnan, N, James, A, Elvira, E, Jayakumar, D, Pratheema, R, Babu, S, Ebenezer, R, Krishnaoorthy, S, Ranganathan, L, Ganesan, M, Shree, M, Guilder, E, Butler, M, Cowdrey, K-A, Robertson, M, Ali, F, McMahon, E, Duffy, E, Chen, Y, Simmonds, C, McConnochie, R, O’Connor, C, El-Khawas, K, Richardson, A, Hill, D, Commons, R, Abdelkharim, H, Saxena, M, Muteithia, M, Dobell-Brown, K, Jha, R, Kalogirou, M, Ellis, C, Krishnamurthy, V, O’Connor, A, Thurairatnam, S, Mukherjee, D, Kaliappan, A, Vertue, M, Nicholson, A, Riches, J, Maloney, G, Kittridge, L, Solesbury, A, Ramos, A, Collins, D, Brickell, K, Reid, L, Smyth, M, Breen, P, Spain, S, Curley, G, McEvoy, N, Geoghegan, P, Clarke, J, Silversides, J, McGuigan, P, Ward, K, O’Neill, A, Finn, S, Wright, C, Green, J, Collins, É, Knott, C, Smith, J, Boschert, C, Slieker, K, Ewalds, E, Sanders, A, Wittenberg, W, Geurts, H, Poojara, L, Sara, T, Nand, K, Reeve, B, Dechert, W, Phillips, B, Oritz-Ruiz de Gordoa, L, Affleck, J, Shaikh, A, Murray, A, Ramanan, M, Frakking, T, Pinnell, J, Robinson, M, Gledhill, L, Wood, T, Sanghavi, R, Bhonagiri, D, Ford, M, Parikh, HG, Avard, B, Nourse, M, McDonald, B, Edmunds, N, Hoiting, O, Peters, M, Rengers, E, Evers, M, Prinssen, A, Morgan, M, Cole, J, Hill, H, Davies, M, Williams, A, Thomas, E, Davies, R, Wise, M, Grimm, P, Soukup, 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S, Wetherill, B, Brajković, A, Babel, J, Sever, H, Dragija, L, Kušan, I, Dushianthan, A, Cusack, R, De Courcy-Golder, K, Salmon, K, Burnish, R, Smith, S, Ruiz, W, Duke, Z, Johns, M, Male, M, Gladas, K, Virdee, S, Swabe, J, Tomlinson, H, Rohde, G, Grünewaldt, A, Bojunga, J, Petros, S, Kunz, K, Schütze, B, Weismann, D, Frey, A, Drayss, M, Goebeler, ME, Flor, T, Fragner, G, Wahl, N, Totzke, J, Sayehli, C, Hakak, S, Altaf, W, O'Sullivan, M, Murphy, A, Walsh, L, Rega La Valle, A, Bewley, J, Sweet, K, Grimmer, L, Johnson, R, Wyatt, R, Morgan, K, Varghese, S, Willis, J, Stratton, E, Kyle, L, Putensen, D, Drury, K, Skorko, A, Bremmer, P, Ward, G, Bassford, C, Sligl, W, Baig, N, Rewa, O, Bagshaw, S, Basile, K, Stavor, D, Burbee, D, McNamara, A, Wunderley, R, Bensen, N, Adams, P, Vita, T, Buhay, M, Scholl, D, Gilliam, M, Winters, J, Doherty, K, Berryman, E, Ghaffari, M, Marroquin, O, Quinn, K, Garrard, W, Kalchthaler, K, Beard, G, Skrtich, A, Bagavathy, K, Drapola, D, Bryan-Morris, K, Arnold, J, Reynolds, B, Hussain, M, Dunsavage, J, Saiyed, S, Hernandez, E, Goldman, J, Brown, C, Comp, S, Raczek, J, Morris, J, Vargas Jr., J, Weiss, D, Hensley, J, Kochert, E, Wnuk, C, Nemeth, C, Mowery, B, Hutchinson, C, Winters, L, McAdams, D, Walker, G, Minnier, T, Wisniewski, M, Mayak, K, McCreary, E, Bariola, R, Viehman, A, Daley, J, Lopus, A, Schmidhofer, M, Ambrosino, R, Keen, S, Toffalo, S, Stambaugh, M, Trimmer, K, Perri, R, Casali, S, Medva, R, Massar, B, Beyerl, A, Burkey, J, Keeler, S, Lowery, M, Oncea, L, Daugherty, J, Sevilla, C, Woelke, A, Dice, J, Weber, L, Roth, J, Ferringer, C, Beer, D, Fesz, J, Carpio, L, Colin, G, Zinzoni, V, Maquigneau, N, Henri-Lagarrigue, M, Pouplet, C, Reill, L, Distler, M, Maselli, A, Martynoga, R, Trask, K, Butler, A, Attwood, B, Parsons, P, Campbell, B, Smith, A, Page, V, Zhao, X, Oza, D, Abrahamson, G, Sheath, B, Young, P, Young, C, Lesona, E, Navarra, L, Cruz, R, Delaney, K, Aguilar-Dano, A, Gojanovic, M, Rhodes, J, Anderson, T, Morris, S, Nayyar, V, Bowen, D, Kong, J, Joy, J, Fuchs, R, Lambert, B, Tai, C, Thomas, A, Keen, A, Tierney, C, Omer, N, Bacon, G, Tridente, A, Shuker, K, Anders, J, Greer, S, Scott, P, Millington, A, Buchanan, P, Binnie, A, Powell, E, McMillan, A, Luk, T, Aref, N, Denmade, C, Sadera, G, Jacob, R, Hughes, D, Sterba, M, Geng, W, Digby, S, Southern, D, Reddy, H, Hulse, S, Campbell, A, Garton, M, Watkins, C, Smuts, S, Quinn, A, Simpson, B, McMillan, C, Finch, C, Hill, C, Cooper, J, Budd, J, Small, C, O’Leary, R, Collins, E, Holland, A, Alexander, P, Felton, T, Ferguson, S, Sellers, K, Ward, L, Yates, D, Birkinshaw, I, Kell, K, Scott, Z, Pearson, H, Hashmi, M, Hassan, N, Panjwani, A, Umrani, Z, Shaikh, M, Ain, Q, Kanwal, D, Van Bree, S, Bouw-Ruiter, M, Osinga, M, Van Zanten, A, McEldrew, R, Rashan, S, Singh, V, Azergui, N, Bari, S, Beltran, M, Brugman, C, Groeneveld, E, Jafarzadeh, M, Keijzer-Timmers, N, Kester, E, Koelink, M, Kwakkenbos-Craanen, M, Okundaye, C, Parker, L, Peters, S, Post, S, Rietveld, I, Scheepstra-Beukers, I, Schreuder, G, Smit, A, Brillinger, N, Markgraf, R, Eichinger, F, Doran, P, Anjum, A, Best-Lane, J, Barton, F, Miller, L, Richards-Belle, A, Saull, M, Sprinckmoller, S, Wiley, D, Darnell, R, Au, C, Lindstrum, K, Cheng, A, Forbes, A, Heritier, S, Trapani, T, Cuthbertson, B, Manoharan, V, Dondrop, A, Tolppa, T, Ehrmann, S, Hullegie, S, Povoa, P, Beasley, R, Daneman, N, McGloughlin, S, Paterson, D, Venkatesh, B, De Jong, M, Uyeki, T, Baillie, K, Netea, M, Orr, K, Patanwala, A, Tong, S, Cooper, N, Galea, J, Leavis, H, Ogungbenro, K, Patawala, A, Rademaker, E, Youngstein, T, Carrier, M, Fergusson, D, Hunt, B, Kumar, A, Laffan, M, Lother, S, Middeldorp, S, Stanworth, S, De Man, A, Masse, M-H, Abraham, J, Arnold, D, Begin, P, Charlewood, R, Chasse, M, Coyne, M, Daly, J, Gosbell, I, Harvala-Simmonds, H, MacLennan, S, McDyer, J, Menon, D, Pridee, N, Roberts, D, Thomas, H, Tinmouth, A, Triulzi, D, Walsh, T, Wood, E, Calfee, C, O’Kane, C, Shyamsundar, M, Sinha, P, Thompson, T, Young, I, Burrell, A, Ferguson, N, Hodgson, C, Orford, N, Phua, J, Baron, R, Epelman, S, Frankfurter, C, Gommans, F, Kim, E, Leaf, D, Vaduganathan, M, Van Kimmenade, R, Sanil, A, Van Beurden, M, Effelaar, E, Schotsman, J, Boyd, C, Harland, C, Shearer, A, Wren, J, Attanayaka, U, Darshana, S, Ishani, P, Udayanga, I, Higgins, AM, Berry, LR, Lorenzi, E, Murthy, S, McQuilten, Z, Mouncey, PR, Al-Beidh, F, Annane, D, Arabi, YM, Beane, A, Van Bentum-Puijk, W, Bhimani, Z, Bonten, MJM, Bradbury, CA, Brunkhorst, FM, Buzgau, A, Buxton, M, Charles, WN, Cove, M, Detry, MA, Estcourt, LJ, Fagbodun, EO, Fitzgerald, M, Girard, TD, Goligher, EC, Goossens, H, Haniffa, R, Hills, T, Horvat, CM, Huang, DT, Ichihara, N, Lamontagne, F, Marshall, JC, McAuley, DF, McGlothlin, A, McGuinness, SP, McVerry, BJ, Neal, MD, Nichol, AD, Parke, RL, Parker, JC, Parry-Billings, K, Peters, SEC, Reyes, LF, Rowan, KM, Saito, H, Santos, MS, Saunders, CT, Serpa-Neto, A, Seymour, CW, Shankar-Hari, M, Stronach, LM, Turgeon, AF, Turner, AM, Van de Veerdonk, FL, Zarychanski, R, Green, C, Lewis, RJ, Angus, DC, McArthur, CJ, Berry, S, Derde, LPG, Gordon, AC, Webb, SA, Lawler, PR, Comm REMAP-CAP Investigators, Apollo - University of Cambridge Repository, Intensive Care Medicine, Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Hôpital Raymond Poincaré [Garches], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Pittsburgh Foundation, PF, Amgen, Health Research Board, HRB: CTN 2014-012, Horizon 2020 Framework Programme, H2020: 101003589, Translational Breast Cancer Research Consortium, TBCRC, Canadian Institutes of Health Research, IRSC: 158584, Heart and Stroke Foundation of Canada, HSF, National Institute for Health and Care Research, NIHR, European Commission, EC, National Health and Medical Research Council, NHMRC: 1101719, APP194811, CS-2016-16-011, GNT2008447, RP-2015-06-18, Office of Health and Medical Research, OHMR, Health Research Council of New Zealand, HRC: 16/631, Eisai, Ministère des Affaires Sociales et de la Santé: PHRC-20-0147, Université Pierre et Marie Curie, UPMC, NIHR Imperial Biomedical Research Centre, BRC, Minderoo Foundation, Funding/Support : The Platform for European Preparedness Against (Re-) emerging Epidemics (PREPARE) consortium by the European Union, FP7-HEALTH-2013-INNOVATION-1 (#602525), the Rapid European COVID-19 Emergency Research response (RECOVER) consortium by the European Union’s Horizon 2020 research and innovation programme (#101003589), the Australian National Health and Medical Research Council (#APP1101719), the Australian Medical Research Future Fund (#APP2002132), the Health Research Council of New Zealand (#16/631), the Canadian Institutes of Health Research Strategy for Patient-Oriented Research Innovative Clinical Trials Program Grant (#158584) and the Canadian Institute of Health Research COVID-19 Rapid Research Funding (#447335), the UK National Institute for Health Research (NIHR) and the NIHR Imperial Biomedical Research Centre, the Health Research Board of Ireland (CTN 2014-012), the UPMC Learning While Doing Program, the Translational Breast Cancer Research Consortium, the French Ministry of Health (PHRC-20-0147), the Wellcome Trust Innovations Project (215522), the Minderoo Foundation, the EU Programme Emergency Support Instrument, the NHS Blood and Transplant Research and Development Programme, the Translational Breast Cancer Research Consortium, the NSW Office of Health and Medical Research, Amgen, Eisai, and the Pittsburgh Foundation. Dr Higgins is funded by an NHMRC Emerging Leadership Fellowship (GNT2008447). Dr McQuilten is funded by an NHMRC Emerging Leadership Fellowship (APP194811). Dr Gordon is funded by an NIHR Research Professorship (RP-2015-06-18) and Dr Shankar-Hari by an NIHR Clinician Scientist Fellowship (CS-2016-16-011). Dr Turgeon is the Chairholder of the Canada Research Chair in Critical Care Neurology and Trauma. Dr Lawler is supported by a career award from the Heart and Stroke Foundation of Canada., and European Project: 602525,EC:FP7:HEALTH,FP7-HEALTH-2013-INNOVATION-1,PREPARE(2014)
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Adult ,Male ,corticosteroid ,[SDV]Life Sciences [q-bio] ,Critical Illness ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,antiplatelet ,Lopinavir ,Adaptive platform trial randomized controlled trial intensive care, pneumonia COVID-19 antiplatelet immunoglobulin antiviral corticosteroid immune modulation anticoagulation ,All institutes and research themes of the Radboud University Medical Center ,Adrenal Cortex Hormones ,Humans ,anticoagulation ,intensive care, pneumonia ,COVID-19 Serotherapy ,Original Investigation ,Medicine(all) ,immune modulation ,Ritonavir ,SARS-CoV-2 ,COVID-19 ,Anticoagulants ,Bayes Theorem ,General Medicine ,Middle Aged ,antiviral ,Receptors, Interleukin-6 ,Adaptive platform trial ,randomized controlled trial ,Female ,Human medicine ,immunoglobulin ,Follow-Up Studies ,Hydroxychloroquine - Abstract
ImportanceThe longer-term effects of therapies for the treatment of critically ill patients with COVID-19 are unknown.ObjectiveTo determine the effect of multiple interventions for critically ill adults with COVID-19 on longer-term outcomes.Design, Setting, and ParticipantsPrespecified secondary analysis of an ongoing adaptive platform trial (REMAP-CAP) testing interventions within multiple therapeutic domains in which 4869 critically ill adult patients with COVID-19 were enrolled between March 9, 2020, and June 22, 2021, from 197 sites in 14 countries. The final 180-day follow-up was completed on March 2, 2022.InterventionsPatients were randomized to receive 1 or more interventions within 6 treatment domains: immune modulators (n = 2274), convalescent plasma (n = 2011), antiplatelet therapy (n = 1557), anticoagulation (n = 1033), antivirals (n = 726), and corticosteroids (n = 401).Main Outcomes and MeasuresThe main outcome was survival through day 180, analyzed using a bayesian piecewise exponential model. A hazard ratio (HR) less than 1 represented improved survival (superiority), while an HR greater than 1 represented worsened survival (harm); futility was represented by a relative improvement less than 20% in outcome, shown by an HR greater than 0.83.ResultsAmong 4869 randomized patients (mean age, 59.3 years; 1537 [32.1%] women), 4107 (84.3%) had known vital status and 2590 (63.1%) were alive at day 180. IL-6 receptor antagonists had a greater than 99.9% probability of improving 6-month survival (adjusted HR, 0.74 [95% credible interval {CrI}, 0.61-0.90]) and antiplatelet agents had a 95% probability of improving 6-month survival (adjusted HR, 0.85 [95% CrI, 0.71-1.03]) compared with the control, while the probability of trial-defined statistical futility (HR >0.83) was high for therapeutic anticoagulation (99.9%; HR, 1.13 [95% CrI, 0.93-1.42]), convalescent plasma (99.2%; HR, 0.99 [95% CrI, 0.86-1.14]), and lopinavir-ritonavir (96.6%; HR, 1.06 [95% CrI, 0.82-1.38]) and the probabilities of harm from hydroxychloroquine (96.9%; HR, 1.51 [95% CrI, 0.98-2.29]) and the combination of lopinavir-ritonavir and hydroxychloroquine (96.8%; HR, 1.61 [95% CrI, 0.97-2.67]) were high. The corticosteroid domain was stopped early prior to reaching a predefined statistical trigger; there was a 57.1% to 61.6% probability of improving 6-month survival across varying hydrocortisone dosing strategies.Conclusions and RelevanceAmong critically ill patients with COVID-19 randomized to receive 1 or more therapeutic interventions, treatment with an IL-6 receptor antagonist had a greater than 99.9% probability of improved 180-day mortality compared with patients randomized to the control, and treatment with an antiplatelet had a 95.0% probability of improved 180-day mortality compared with patients randomized to the control. Overall, when considered with previously reported short-term results, the findings indicate that initial in-hospital treatment effects were consistent for most therapies through 6 months.
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- 2023
29. Hypercapnic Failure in Acute Exacerbated COPD Patients: Severe Airflow Limitation as an Early Warning Signal
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Achim Grünewaldt, Norbert Fritsch, and Gernot Rohde
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General Medicine ,COPD ,comorbidity ,hypercapnic failure ,exacerbation ,non-invasive ventilation - Abstract
Background: Hypercapnic failure is a severe complication of COPD disease progression, which is associated with a high morbidity and mortality. The aim of this study was to examine the association of comorbidity and clinical risk factors with the development of hypercapnia in acute exacerbated COPD patients. Methods: In this retrospective monocentric cohort study, we examined the influence of the clinical parameters and the comorbidity of hospitalized patients with the acute exacerbation of COPD on the development of hypercapnia by performing multivariate logistic regression and a receiver operating characteristic analysis. Results: In total, 275 patient cases with COPD exacerbation were enrolled during the period from January 2011 until March 2015, where 104 patients (37.8%) with hypercapnia were identified. The logistic regression analysis revealed severe airflow limitation (decreased FEV1) as the main factor associated with the development of hypercapnia. In the ROC analysis, we determined an FEV1 of 42.12%, which was predicted with a sensitivity of 82.6% and specificity of 55%, and an absolute value of FEV1 of 0.8 L, with a sensitivity of 0.62 and specificity of 0.79 as the cut off points, respectively. We could not verify an association with the patient’s condition or the laboratory surrogate parameters of organ failure. Conclusion: Severe airflow limitation is an important risk factor that is associated with hypercapnic failure in acute exacerbated COPD patients. Validation in prospective cohorts is warranted and should focus on more intensive monitoring of these at-risk patients.
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- 2022
30. Pulmonary impairment independently determines mortality in critically ill patients with acute‐on‐chronic liver failure
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Schulz, Martin S., primary, Mengers, Jan, additional, Gu, Wenyi, additional, Drolz, Andreas, additional, Ferstl, Philip G., additional, Amoros, Alex, additional, Uschner, Frank E., additional, Ackermann, Nora, additional, Guttenberg, Georg, additional, Queck, Alexander, additional, Brol, Maximilian J., additional, Graf, Christiana, additional, Stoffers, Philipp, additional, de la Vera, Anna‐Lena Laguna, additional, Cremonese, Carla, additional, Erasmus, Hans‐Peter, additional, Welker, Martin W., additional, Grünewaldt, Achim, additional, Arroyo, Vincente, additional, Bojunga, Jörg, additional, Fernandez, Javier, additional, Zeuzem, Stefan, additional, Kluwe, Johannes, additional, Peiffer, Kai‐Hendrik, additional, Welsch, Christoph, additional, Fuhrmann, Valentin, additional, Rohde, Gernot, additional, and Trebicka, Jonel, additional
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- 2022
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31. Dyspnoe und Komorbidität beim Lungenkarzinom: Warum die Anamnese so wichtig ist
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Gernot Rohde, S. Stützle, A Grünewaldt, and A. Lehn
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Pulmonary and Respiratory Medicine ,Gynecology ,03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,business.industry ,030220 oncology & carcinogenesis ,Pulmonary disease ,Medicine ,030212 general & internal medicine ,business - Abstract
Zusammenfassung Ziel Dyspnoe ist ein häufiges und schwer beeinträchtigendes Krankheitssymptom bei Patienten mit fortgeschrittenem Lungenkarzinom. Exogene wie endogene Faktoren tragen zum subjektiven Symptom Luftnot bei. Um eine effektive Therapie einleiten zu können, ist die Kenntnis von beeinflussbaren Faktoren essenziell. Mit dem Ziel, die Atemnot gezielter behandeln zu können, wurde in dieser Arbeit die Auswirkung von Begleitfaktoren und Komorbiditäten auf den Schweregrad von Luftnot bei Patienten mit Lungenkarzinom untersucht. Methode Im Rahmen einer prospektiven, monozentrischen Beobachtungsstudie wurde der Schweregrad der Atemnot bei Patienten mit fortgeschrittenem Lungenkarzinom anhand des mMRC-Scores abgefragt und standardisiert nach kardialer oder pulmonaler Komorbidität befragt. Zudem wurden Schmerzsymptomatik und psychische Belastung der Patienten durch die Tumorerkrankung anhand numerischer Ratingskalen (NRS) abgefragt. Ergebnisse 25 (48,1 %) von 52 eingeschlossenen Lungenkarzinompatienten gaben mäßige bis starke Dyspnoe an. Vorbekannte COPD, kardiopulmonale Begleiterkrankungen, starke Schmerzen, eine obstruktive Ventilationsstörung in der Lungenfunktion sowie nachweisbare Pleuraergüsse korrelierten in der logistischen Regressionsanalyse mit dem Auftreten von Dyspnoeschweregraden ≥ 3 in der mMRC-Skala. In dieser Untersuchung war auch das niedrigere UICC-Stadium III bzw. eine M0-Situation mit einer höheren Wahrscheinlichkeit einer schweren Dyspnoe korreliert als ein höheres Stadium IV nach UICC. Schlussfolgerung Unsere Untersuchung bestätigt die klinische Relevanz von Dyspnoe bei Lungenkarzinompatienten. Die Wahrscheinlichkeit für das Auftreten dyspnoeischer Beschwerden wird durch Begleitsymptome wie starke Schmerzen und insbesondere durch das Vorhandensein von kardialen oder pulmonalen Komorbiditäten wesentlich beeinflusst. Eine effektive Behandlung von Luftnot sollte daher diese begleitenden Faktoren in der Therapie berücksichtigen.
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- 2021
32. Finnish female prisoners - heavy consumers of health services
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VIITANEN, PÄIVI, VARTIAINEN, HEIKKI, AARNIO, JORMA, VON GRUENEWALDT, VIRPI, HAKAMÄKI, SIRPA, LINTONEN, TOMI, MATTILA, AINO K, WUOLIJOKI, TERHI, and JOUKAMAA, MATTI
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- 2013
33. Pulmonary impairment independently determines mortality in critically ill patients with acute-on-chronic liver failure
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Martin S. Schulz, Jan Mengers, Wenyi Gu, Andreas Drolz, Philip G. Ferstl, Alex Amoros, Frank E. Uschner, Nora Ackermann, Georg Guttenberg, Alexander Queck, Maximilian J. Brol, Christiana Graf, Philipp Stoffers, Anna‐Lena Laguna de la Vera, Carla Cremonese, Hans‐Peter Erasmus, Martin W. Welker, Achim Grünewaldt, Vincente Arroyo, Jörg Bojunga, Javier Fernandez, Stefan Zeuzem, Johannes Kluwe, Kai‐Hendrik Peiffer, Christoph Welsch, Valentin Fuhrmann, Gernot Rohde, and Jonel Trebicka
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Hepatology - Abstract
In ACLF patients, an adequate risk stratification is essential, especially for liver transplant allocation, since ACLF is associated with high short-term mortality. The CLIF-C ACLF score is the best prognostic model to predict outcome in ACLF patients. While lung failure is generally regarded as signum malum in ICU care, this study aims to evaluate and quantify the role of pulmonary impairment on outcome in ACLF patients.In this retrospective study, 498 patients with liver cirrhosis and admission to IMC/ICU were included. ACLF was defined according to EASL-CLIF criteria. Pulmonary impairment was classified into three groups: unimpaired ventilation, need for mechanical ventilation and defined pulmonary failure. These factors were analysed in different cohorts, including a propensity score-matched ACLF cohort.Mechanical ventilation and pulmonary failure were identified as independent risk factors for increased short-term mortality. In matched ACLF patients, the presence of pulmonary failure showed the highest 28-day mortality (83.7%), whereas mortality rates in ACLF with mechanical ventilation (67.3%) and ACLF without pulmonary impairment (38.8%) were considerably lower (p .001). Especially in patients with pulmonary impairment, the CLIF-C ACLF score showed poor predictive accuracy. Adjusting the CLIF-C ACLF score for the grade of pulmonary impairment improved the prediction significantly.This study highlights that not only pulmonary failure but also mechanical ventilation is associated with worse prognosis in ACLF patients. The grade of pulmonary impairment should be considered in the risk assessment in ACLF patients. The new score may be useful in the selection of patients for liver transplantation.
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- 2022
34. Comorbidity defines asthmatic patients' risk of COVID-19 hospitalization: A global perspective
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Chrysanthi Skevaki, R. Sharon Chinthrajah, Daria Fomina, Gernot Rohde, Shu Cao, Ziyuan He, Sofia Serdotetskova, Christian Seidemann, Achim Grünewaldt, Abisha Vengadeswaran, Min Xie, Antonina Karsonova, Alexander Karaulov, Kari C. Nadeau, Ho-Ryun Chung, and Harald Renz
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Immunology ,Immunology and Allergy - Abstract
The global epidemiology of asthma among patients with coronavirus disease 2019 (COVID-19) presents striking geographic differences, defining prevalence zones of high and low co-occurrence of asthma and COVID-19.We aimed to compare asthma prevalence among hospitalized patients with COVID-19 in major global hubs across the world by applying common inclusion criteria and definitions.We built a network of 6 academic hospitals in Stanford (Stanford University)/the United States; Frankfurt (Goethe University), Giessen (Justus Liebig University), and Marburg (Philipps University)/Germany; and Moscow (Clinical Hospital 52 in collaboration with Sechenov University)/Russia. We collected clinical and laboratory data for patients hospitalized due to COVID-19.Asthmatic individuals were overrepresented among hospitalized patients with COVID-19 in Stanford and underrepresented in Moscow and Germany as compared with their prevalence among adults in the local community. Asthma prevalence was similar among patients hospitalized in an intensive care unit and patients hospitalized in other than an intensive care unit, which implied that the risk for development of severe COVID-19 was not higher among asthmatic patients. The numbers of males and comorbidities were higher among patients with COVID-19 in the Stanford cohort, and the most frequent comorbidities among these patients with asthma were other chronic inflammatory airway disorders such as chronic obstructive pulmonary disease.The observed disparity in COVID-19-associated risk among asthmatic patients across countries and continents is connected to the varying prevalence of underlying comorbidities, particularly chronic obstructive pulmonary disease.
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- 2022
35. Comorbidity defines risk of asthmatics for COVID-19 hospitalization: a global perspective
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Chrysanthi Skevaki, Sharon Chinthrajah, Daria Fomina, Gernot Rohde, Shu Cao, Ziyuan He, Sofia Serdotetskova, Christian Seidemann, Achim Grünewaldt, Abisha Vengadeswaran, Min Xie, Antonina Karsonova, Alexander Karaulov, Kari Nadeau, Ho-Ryun Chung, and Harald Renz
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Background: The global epidemiology of asthma among COVID-19 patients presents striking geographic differences defining high and low [asthma and COVID-19] co-occurrence prevalence zones (1). The objective of the present study was to compare asthma prevalence among hospitalized COVID-19 patients in major global hubs across the world with the application of common inclusion criteria and definitions. Methods: We built a network of six academic hospitals in Stanford (Stanford University)/USA, Frankfurt (Goethe University), Giessen (Justus Liebig University) and Marburg (Philipps University)/Germany, and Moscow (Clinical Hospital 52 in collaboration with Sechenov University)/Russia. We collected clinical and laboratory data for patients hospitalized due to COVID-19. Comorbidities reported were based on the 2020 International Classification of Diseases-10th Revision codes. Results: Asthmatics were overrepresented among hospitalized COVID-19 patients in Stanford and underrepresented in Moscow and Germany as compared to the prevalence among adults in the local community. Asthma prevalence was similar among ICU and hospital non-ICU patients, which implied that the risk for developing severe COVID-19 was not higher among asthmatics. The number of males and comorbidities was higher among COVID-19 patients in the Stanford cohort, and the most frequent comorbidities among these asthma patients were other chronic inflammatory airway disorders such as chronic obstructive pulmonary disease (COPD). Conclusion: Observed disparity in COVID-19-associated risk among asthmatics across countries and continents is connected to varying prevalence of underlying comorbidities, particularly COPD. Public health policies in the future will need to consider comorbidities with an emphasis on COPD for prioritization of vaccination and preemptive treatment.
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- 2022
36. Einsatz von Highflow-Sauerstofftherapie im häuslichen Bereich bei Patienten mit interstitieller Lungenerkrankung und zystischer Fibrose
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A Grünewaldt and G Rohde
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- 2022
37. Pulmonary impairment independently determines mortality in critically ill patients with acute-on-chronic liver failure
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Schulz, Martin S., Mengers, Jan, Gu, Wenyi, Drolz, Andreas, Ferstl, Philip, Amoros, Alex, Uschner, Frank Erhard, Ackermann, Nora, Guttenberg, Georg, Queck, Alexander David Roger, Brol, Maximilian, Graf, Christiana, Stoffers, Philipp Clemens, Laguna de la Vera, Anna-Lena, Cremonese, Carla-Luisa Elsa, Erasmus, Hans-Peter, Welker, Martin-Walter, Grünewaldt, Achim Bernd, Arroyo, Vicente, Bojunga, Jörg, Fernandez, Javier, Zeuzem, Stefan, Kluwe, Johannes, Peiffer, Kai-Henrik, Welsch, Christoph, Fuhrmann, Valentin, Rohde, Gernot Gerhard Ulrich, Trebicka, Jonel, Schulz, Martin S., Mengers, Jan, Gu, Wenyi, Drolz, Andreas, Ferstl, Philip, Amoros, Alex, Uschner, Frank Erhard, Ackermann, Nora, Guttenberg, Georg, Queck, Alexander David Roger, Brol, Maximilian, Graf, Christiana, Stoffers, Philipp Clemens, Laguna de la Vera, Anna-Lena, Cremonese, Carla-Luisa Elsa, Erasmus, Hans-Peter, Welker, Martin-Walter, Grünewaldt, Achim Bernd, Arroyo, Vicente, Bojunga, Jörg, Fernandez, Javier, Zeuzem, Stefan, Kluwe, Johannes, Peiffer, Kai-Henrik, Welsch, Christoph, Fuhrmann, Valentin, Rohde, Gernot Gerhard Ulrich, and Trebicka, Jonel
- Abstract
Background & Aims: In ACLF patients, an adequate risk stratification is essential, especially for liver transplant allocation, since ACLF is associated with high short-term mortality. The CLIF-C ACLF score is the best prognostic model to predict outcome in ACLF patients. While lung failure is generally regarded as signum malum in ICU care, this study aims to evaluate and quantify the role of pulmonary impairment on outcome in ACLF patients. Methods: In this retrospective study, 498 patients with liver cirrhosis and admission to IMC/ICU were included. ACLF was defined according to EASL-CLIF criteria. Pulmonary impairment was classified into three groups: unimpaired ventilation, need for mechanical ventilation and defined pulmonary failure. These factors were analysed in different cohorts, including a propensity score-matched ACLF cohort. Results: Mechanical ventilation and pulmonary failure were identified as independent risk factors for increased short-term mortality. In matched ACLF patients, the presence of pulmonary failure showed the highest 28-day mortality (83.7%), whereas mortality rates in ACLF with mechanical ventilation (67.3%) and ACLF without pulmonary impairment (38.8%) were considerably lower (p < .001). Especially in patients with pulmonary impairment, the CLIF-C ACLF score showed poor predictive accuracy. Adjusting the CLIF-C ACLF score for the grade of pulmonary impairment improved the prediction significantly. Conclusions: This study highlights that not only pulmonary failure but also mechanical ventilation is associated with worse prognosis in ACLF patients. The grade of pulmonary impairment should be considered in the risk assessment in ACLF patients. The new score may be useful in the selection of patients for liver transplantation.
- Published
- 2022
38. Comorbidity defines risk of asthmatics for COVID-19 hospitalization: a global perspective
- Author
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Skevaki, Chrysanthi, primary, Chinthrajah, Sharon, additional, Fomina, Daria, additional, Rohde, Gernot, additional, Cao, Shu, additional, He, Ziyuan, additional, Serdotetskova, Sofia, additional, Seidemann, Christian, additional, Grünewaldt, Achim, additional, Vengadeswaran, Abisha, additional, Xie, Min, additional, Karsonova, Antonina, additional, Karaulov, Alexander, additional, Nadeau, Kari, additional, Chung, Ho-Ryun, additional, and Renz, Harald, additional
- Published
- 2022
- Full Text
- View/download PDF
39. Einsatz von Highflow-Sauerstofftherapie im häuslichen Bereich bei Patienten mit interstitieller Lungenerkrankung und zystischer Fibrose
- Author
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Grünewaldt, A, additional and Rohde, G, additional
- Published
- 2022
- Full Text
- View/download PDF
40. Letalität der ambulant erworbenen Pneumonie nicht unterschätzen!
- Author
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Gernot Rohde, Achim Grünewaldt, Christian Hügel, and Carla Bellinghausen
- Subjects
Gynecology ,medicine.medical_specialty ,business.industry ,General Medicine ,030204 cardiovascular system & hematology ,medicine.disease_cause ,medicine.disease ,Lung ultrasound ,03 medical and health sciences ,Pneumonia ,0302 clinical medicine ,Streptococcus pneumoniae ,medicine ,030212 general & internal medicine ,business - Abstract
Die ambulant erworbene Pneumonie geht vor allem bei intensivmedizinischer Behandlungsnotwendigkeit mit einer hohen Letalitat einher. Risikoscores helfen bei der Schweregradabschatzung und ermoglichen Ihnen, die richtige Therapieentscheidung zu treffen.
- Published
- 2020
41. Hypercapnic Failure in Acute Exacerbated COPD Patients: Severe Airflow Limitation as an Early Warning Signal.
- Author
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Grünewaldt, Achim, Fritsch, Norbert, and Rohde, Gernot
- Subjects
- *
CHRONIC obstructive pulmonary disease , *AIR flow , *RECEIVER operating characteristic curves , *LOGISTIC regression analysis , *DISEASE exacerbation - Abstract
Background: Hypercapnic failure is a severe complication of COPD disease progression, which is associated with a high morbidity and mortality. The aim of this study was to examine the association of comorbidity and clinical risk factors with the development of hypercapnia in acute exacerbated COPD patients. Methods: In this retrospective monocentric cohort study, we examined the influence of the clinical parameters and the comorbidity of hospitalized patients with the acute exacerbation of COPD on the development of hypercapnia by performing multivariate logistic regression and a receiver operating characteristic analysis. Results: In total, 275 patient cases with COPD exacerbation were enrolled during the period from January 2011 until March 2015, where 104 patients (37.8%) with hypercapnia were identified. The logistic regression analysis revealed severe airflow limitation (decreased FEV1) as the main factor associated with the development of hypercapnia. In the ROC analysis, we determined an FEV1 of 42.12%, which was predicted with a sensitivity of 82.6% and specificity of 55%, and an absolute value of FEV1 of 0.8 L, with a sensitivity of 0.62 and specificity of 0.79 as the cut off points, respectively. We could not verify an association with the patient's condition or the laboratory surrogate parameters of organ failure. Conclusion: Severe airflow limitation is an important risk factor that is associated with hypercapnic failure in acute exacerbated COPD patients. Validation in prospective cohorts is warranted and should focus on more intensive monitoring of these at-risk patients. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
42. Pulmonary impairment independently determines mortality in critically ill patients with acute‐on‐chronic liver failure.
- Author
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Schulz, Martin S., Mengers, Jan, Gu, Wenyi, Drolz, Andreas, Ferstl, Philip G., Amoros, Alex, Uschner, Frank E., Ackermann, Nora, Guttenberg, Georg, Queck, Alexander, Brol, Maximilian J., Graf, Christiana, Stoffers, Philipp, de la Vera, Anna‐Lena Laguna, Cremonese, Carla, Erasmus, Hans‐Peter, Welker, Martin W., Grünewaldt, Achim, Arroyo, Vincente, and Bojunga, Jörg
- Subjects
LIVER failure ,PATIENT selection ,CRITICALLY ill ,ALLOCATION of organs, tissues, etc. ,ARTIFICIAL respiration - Abstract
Background & Aims: In ACLF patients, an adequate risk stratification is essential, especially for liver transplant allocation, since ACLF is associated with high short‐term mortality. The CLIF‐C ACLF score is the best prognostic model to predict outcome in ACLF patients. While lung failure is generally regarded as signum malum in ICU care, this study aims to evaluate and quantify the role of pulmonary impairment on outcome in ACLF patients. Methods: In this retrospective study, 498 patients with liver cirrhosis and admission to IMC/ICU were included. ACLF was defined according to EASL‐CLIF criteria. Pulmonary impairment was classified into three groups: unimpaired ventilation, need for mechanical ventilation and defined pulmonary failure. These factors were analysed in different cohorts, including a propensity score‐matched ACLF cohort. Results: Mechanical ventilation and pulmonary failure were identified as independent risk factors for increased short‐term mortality. In matched ACLF patients, the presence of pulmonary failure showed the highest 28‐day mortality (83.7%), whereas mortality rates in ACLF with mechanical ventilation (67.3%) and ACLF without pulmonary impairment (38.8%) were considerably lower (p <.001). Especially in patients with pulmonary impairment, the CLIF‐C ACLF score showed poor predictive accuracy. Adjusting the CLIF‐C ACLF score for the grade of pulmonary impairment improved the prediction significantly. Conclusions: This study highlights that not only pulmonary failure but also mechanical ventilation is associated with worse prognosis in ACLF patients. The grade of pulmonary impairment should be considered in the risk assessment in ACLF patients. The new score may be useful in the selection of patients for liver transplantation. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
43. GABBRO AND NORITE Gabbro and norite
- Author
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Von Gruenewaldt, Gerhard and Bowes, D. R.
- Published
- 1990
- Full Text
- View/download PDF
44. BUSHVELD COMPLEX Bushveld complex
- Author
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Von Gruenewaldt, Gerhard and Bowes, D. R.
- Published
- 1990
- Full Text
- View/download PDF
45. Early Precambrian layered intrusions
- Author
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Hatton, C. J., von Gruenewaldt, G., Hall, R. P., editor, and Hughes, D. J., editor
- Published
- 1990
- Full Text
- View/download PDF
46. Rhinoviren
- Author
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A. Grünewaldt, C. Hügel, and G. G. U. Rohde
- Subjects
Internal Medicine - Published
- 2019
47. [Dyspnoea and Comorbidity in Lung Cancer-Patients: The Therapy Starts with Taking the Patients History]
- Author
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A, Grünewaldt, S, Stützle, A, Lehn, and G, Rohde
- Subjects
Pulmonary Disease, Chronic Obstructive ,Dyspnea ,Lung Neoplasms ,Humans ,Comorbidity ,Prospective Studies ,Severity of Illness Index - Abstract
Dyspnoea is a frequent and compromising symptom in patients with advanced and metastatic lung cancer. Exogenous as well as endogenous factors contribute to development of shortness of breath. Knowledge of these influences is essential for effective treatment of this important symptom. In our study, we evaluated the influence of cofactors and comorbidity on development of dyspnoea in lung cancer patients for the purpose of effective therapy of shortness of breath in this target group. In this prospective monocentric study, we registered severity of dyspnoea in advanced lung cancer patients using the modified Medical Research Council-Scale (mMRC-scale). Patients' history of COPD and cardiopulmonary comorbidity was recorded using a standardized questionnaire. Moreover, cofactors such as pain or cancer-induced mental stress were documented by visual rating scale. 25 (48,1 %) of 52 recruited lung cancer-patients reported moderate or severe dyspnoea. In logistic regression analysis history of COPD or cardiopulmonary comorbidity, severe pain, airway obstruction or pleural effusion were associated with severe dyspnoea (mMRC-scale ≥ 3). Furthermore, in our study cohort lower cancer level III UICC and absence of metastasis correlated with severe dyspnoea. Our findings confirm the relevance of dyspnoea in patients with advanced lung cancer. Probability of occurrence is influenced by comorbidity and cofactors. The knowledge of these factors contributes to better understanding of occurrence and treatment of dyspnoea.ZIEL: Dyspnoe ist ein häufiges und schwer beeinträchtigendes Krankheitssymptom bei Patienten mit fortgeschrittenem Lungenkarzinom. Exogene wie endogene Faktoren tragen zum subjektiven Symptom Luftnot bei. Um eine effektive Therapie einleiten zu können, ist die Kenntnis von beeinflussbaren Faktoren essenziell. Mit dem Ziel, die Atemnot gezielter behandeln zu können, wurde in dieser Arbeit die Auswirkung von Begleitfaktoren und Komorbiditäten auf den Schweregrad von Luftnot bei Patienten mit Lungenkarzinom untersucht. Im Rahmen einer prospektiven, monozentrischen Beobachtungsstudie wurde der Schweregrad der Atemnot bei Patienten mit fortgeschrittenem Lungenkarzinom anhand des mMRC-Scores abgefragt und standardisiert nach kardialer oder pulmonaler Komorbidität befragt. Zudem wurden Schmerzsymptomatik und psychische Belastung der Patienten durch die Tumorerkrankung anhand numerischer Ratingskalen (NRS) abgefragt. 25 (48,1 %) von 52 eingeschlossenen Lungenkarzinompatienten gaben mäßige bis starke Dyspnoe an. Vorbekannte COPD, kardiopulmonale Begleiterkrankungen, starke Schmerzen, eine obstruktive Ventilationsstörung in der Lungenfunktion sowie nachweisbare Pleuraergüsse korrelierten in der logistischen Regressionsanalyse mit dem Auftreten von Dyspnoeschweregraden ≥ 3 in der mMRC-Skala. In dieser Untersuchung war auch das niedrigere UICC-Stadium III bzw. eine M0-Situation mit einer höheren Wahrscheinlichkeit einer schweren Dyspnoe korreliert als ein höheres Stadium IV nach UICC. Unsere Untersuchung bestätigt die klinische Relevanz von Dyspnoe bei Lungenkarzinompatienten. Die Wahrscheinlichkeit für das Auftreten dyspnoeischer Beschwerden wird durch Begleitsymptome wie starke Schmerzen und insbesondere durch das Vorhandensein von kardialen oder pulmonalen Komorbiditäten wesentlich beeinflusst. Eine effektive Behandlung von Luftnot sollte daher diese begleitenden Faktoren in der Therapie berücksichtigen.
- Published
- 2021
48. Modifikation des CLIF-C ACLF-Scores für die Prognoseabschätzung bei Schutzintubation und Lungenversagen
- Author
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A Queck, Maximilian J. Brol, S Zeuzem, M Schulz, C Graf, J Bojunga, N Ackermann, MW Welker, MM Mücke, J Trebicka, J Mengers, G Rohde, G Guttenberg, A Grünewaldt, KH Peiffer, Ferstl Pg, and FE Uschner
- Published
- 2021
49. Charakteristika und Behandlung von Patienten mit fibrosierender interstitieller Lungenerkrankung in der klinischen Praxis: INSIGHTS-ILD Register.
- Author
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Behr, J, Kreuter, M, Prasse, A, Günther, A, Bonella, F, Pittrow, D, Neurohr, C, Wälscher, J, Grünewaldt, A, Ewert, R, Markart, P, Gesierich, W, Biller, H, Westhoff, M, Eisenmann, S, Andreica, I, Wilkens, H, Wirtz, H, Neff, U, and Budweiser, S
- Published
- 2024
- Full Text
- View/download PDF
50. [State of the art in diagnosis and therapy of community aquired pneumonia]
- Author
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Achim, Grünewaldt, Christian, Hügel, Carla, Bellinghausen, and Gernot, Rohde
- Subjects
Community-Acquired Infections ,Humans ,Pneumonia - Published
- 2020
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