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Objectives: This study aimed to evaluate the eicosanoid and pro-resolutive parameters in patients with Post-COVID Syndrome (PCS) during a 12-week supplementation with a marine oil enriched in specialized pro-resolving mediators (SPMs). Patient and methods: This study was conducted on 53 adult patients with PCS. The subjects included must have had a positive COVID-19 test (PCR, fast antigen test, or serologic test) and persistent symptoms related to COVID-19 at least 12 weeks before their enrolment in the study. The following parameters were evaluated: polyunsaturated fatty acids EPA, DHA, ARA, and DPA; specialized pro-resolving mediators (SPMs), 17-HDHA, 18-HEPE, 14-HDHA, resolvins, maresins, protectins, and lipoxins. The eicosanoids group included prostaglandins, thromboxanes, and leukotrienes. The development of the clinical symptoms of fatigue and dyspnea were evaluated using the Fatigue Severity Scale (FSS) and the Modified Medical Research Council (mMRC) Dyspnea Scale. Three groups with different intake amounts were evaluated (daily use of 500 mg, 1500 mg, and 3000 mg) and compared to a control group not using the product. Results: In the serum from patients with PCS, an increase in 17-HDHA, 18-HEPE, and 14-HDHA could be observed, and a decrease in the ratio between the pro-inflammatory and pro-resolutive lipid mediators was detected; both differences were significant (p < 0.05). There were no differences found between the three treatment groups. Fatigue and dyspnea showed a trend of improvement after supplementation in all groups. Conclusions: A clear enrichment in the serum of the three monohydroxylated SPMs could be observed at a dosage of 500 mg per day. Similarly, a clear improvement in fatigue and dyspnea was observed with this dosage.

Objectives: This study aimed to evaluate the eicosanoid and pro-resolutive parameters in patients with Post-COVID Syndrome (PCS) during a 12-week supplementation with a marine oil enriched in specialized pro-resolving mediators (SPMs). Patient and methods: This study was conducted on 53 adult patients with PCS. The subjects included must have had a positive COVID-19 test (PCR, fast antigen test, or serologic test) and persistent symptoms related to COVID-19 at least 12 weeks before their enrolment in the study. The following parameters were evaluated: polyunsaturated fatty acids EPA, DHA, ARA, and DPA; specialized pro-resolving mediators (SPMs), 17-HDHA, 18-HEPE, 14-HDHA, resolvins, maresins, protectins, and lipoxins. The eicosanoids group included prostaglandins, thromboxanes, and leukotrienes. The development of the clinical symptoms of fatigue and dyspnea were evaluated using the Fatigue Severity Scale (FSS) and the Modified Medical Research Council (mMRC) Dyspnea Scale. Three groups with different intake amounts were evaluated (daily use of 500 mg, 1500 mg, and 3000 mg) and compared to a control group not using the product. Results: In the serum from patients with PCS, an increase in 17-HDHA, 18-HEPE, and 14-HDHA could be observed, and a decrease in the ratio between the pro-inflammatory and pro-resolutive lipid mediators was detected; both differences were significant (p < 0.05). There were no differences found between the three treatment groups. Fatigue and dyspnea showed a trend of improvement after supplementation in all groups. Conclusions: A clear enrichment in the serum of the three monohydroxylated SPMs could be observed at a dosage of 500 mg per day. Similarly, a clear improvement in fatigue and dyspnea was observed with this dosage. [ABSTRACT FROM AUTHOR]

The German Conrad Johann Martin Langenbeck made important contributions to anatomical and surgical knowledge during the late 18th and early 19th centuries. However, His work and legacy is little known and difficult to access, both in Europe and in America. Literature review of the databases PubMed, LILACS, Cochrane Library; "Google" and university libraries. The following keywords have been used: "anatomy and surgery". In this analysis a critical analysis of the known literature about this historical figure is carried out. His multiple contributions to the study of human morphology, his surgical interventions, his legacy at the University of Göttingen and the German model of surgery are noted. Langenbeck was a prominent anatomist, surgeon, professor and researcher, before the discovery of anesthesia changed everything, a time when cadaver dissection was essential to the design of successful operations. The name of CJM Langenbeck will always endure through his work, anatomical terms and operations, and he should be remembered as the last anatomist surgeon of the 19th century. [ABSTRACT FROM AUTHOR]

Objetivo: El objetivo del presente estudio fue comparar la calidad de vida relacionada con la salud del paciente trasplantado renal frente al paciente en hemodiálisis. Material y Método: Estudio observacional comparativo por emparejamiento (1:2) en 240 pacientes (80 en hemodiálisis y 160 trasplantados renales). El muestreo fue no probabilístico intencionado por emparejamiento. El emparejamiento se realizó por: edad, sexo y comorbilidad. Se utilizó el cuestionario KDQOL-SF para analizar calidad de vida relacionada con la salud. Resultados: Los pacientes tenían una edad de 59,80±12,45 años. Los pacientes trasplantados presentaron mejores puntuaciones, con diferencias significativas, en todas las dimensiones de las Escalas específicas para las enfermedades renales, excepto en el Apoyo Social. De igual forma, puntuaron mejor con diferencias significativas, los pacientes trasplantados en todas las dimensiones en el cuestionario SF-36. Los pacientes diabéticos trasplantados puntuaron peor en las dimensiones Carga de la enfermedad renal y Dolor; y los pacientes diabéticos en diálisis, en el Rol emocional. En el grupo de trasplantados, las mujeres puntuaron peor de forma significativa, en las dimensiones Listado de síntomas/problemas, Efectos de la enfermedad, Dolor y Vitalidad; y el grupo de pacientes en hemodiálisis, las mujeres puntuaron peor en la Función física. Conclusiones: Emparejados por edad, sexo y diabetes, los pacientes trasplantados renales presentan mejor calidad de vida relacionada con la salud que los pacientes en hemodiálisis, tanto en las Escalas específicas para la enfermedad renal como en las dimensiones del SF-36. En ambos grupos, los pacientes diabéticos presentan peor calidad de vida que los no diabéticos.

Introducción: Los pacientes con Enfermedad Renal Crónica Avanzada, sufren una amplia variedad de síntomas físicos y psicológicos. Al llegar a estadios finales, sufren alteraciones significativas en la salud física, mental, emocional y social, destacándose el impacto en la calidad del sueño. Objetivo: Analizar las principales alteraciones del sueño en pacientes con Enfermedad Renal Crónica Avanzada. Material y Método: Se llevó a cabo un estudio observacional descriptivo transversal en el Servicio de Nefrología del Hospital Universitario Reina Sofía de Córdoba en pacientes con Enfermedad Renal Crónica Avanzada en estadios 4-5. Se estudiaron las alteraciones del sueño mediante el cuestionario Índice de Calidad de Sueño de Pittsburg y su relación con otras variables como la edad, sexo, comorbilidad, Hemoglobina, Creatinina Sérica e Índice de Masa Corporal. Resultados: Se estudiaron 119 pacientes, con una edad media de 67,61±14,89 años; 52 mujeres (43,7%). El valor medio del Índice de Calidad de Sueño fue de 9,66±4 puntos. El 83,2% de los pacientes presentaban alteraciones del sueño (puntuación >5 puntos). Esta puntuación mostró tener una relación significativa con la comorbilidad y la edad. No se encontraron relaciones entre las alteraciones del sueño con el sexo, aclaramiento renal ni Índice de Masa Corporal. Conclusión: Una mayoría de los pacientes con Enfermedad Renal Crónica Avanzada en estadios 4-5 presentan alteraciones del sueño. Estas alteraciones están relacionadas con mayor comorbilidad y edad avanzada, sin que el sexo, el aclaramiento renal o el Índice de Masa Corporal tengan relación con esta alteración, al menos en la muestra estudiada.

PCOS as the most common endocrine disorder of women in their reproductive age affects between 5–15% of the female population. Apart from its cardinal symptoms, like irregular and anovulatory cycles, hyperandrogenemia and a typical ultrasound feature of the ovary, obesity, and insulin resistance are often associated with the disease. Furthermore, PCOS represents a status of chronic inflammation with permanently elevated levels of inflammatory markers including IL-6 and IL-18, TNF-α, and CRP. Inflammation, as discovered only recently, consists of two processes occurring concomitantly: active initiation, involving “classical” mediators including prostaglandins and leukotrienes, and active resolution processes based on the action of so-called specialized pro-resolving mediators (SPMs). These novel lipid mediator molecules derive from the essential ω3-poly-unsaturated fatty acids (PUFAs) DHA and EPA and are synthesized via specific intermediates. The role and benefits of SPMs in chronic inflammatory diseases like obesity, atherosclerosis, and Diabetes mellitus has become a subject of intense research during the last years and since PCOS features several of these pathologies, this review aims at summarizing potential roles of SPMs in this disease and their putative use as novel therapeutics.

Introduction: The illustrated anatomical atlases of the 19th century created a new visual language, preparing students for dissection and surgeons for operating. Objective: The objective of this study is to analyze the dissection atlases of the 19th century from a specialty perspective of the abdominal wall. Method: Literature review of PubMed, LILACS, Cochrane Library databases; supplementary search using Google and university libraries. As keywords have been used: abdominal wall, inguinal nerves, ilioinguinal nerve, iliohipogastric nerve, genitocrural nerve, hernia, anatomy and surgery. A critical analysis of texts from any country or language is carried out, with no time limit. Results: 42 illustrated texts are analyzed to select 5 German, 3 English and 4 French atlases. The inguinal blades, the surgical contribution and the neural and vascular variants of corona mortis are discussed. Conclusions: The descriptive anatomy of the 18th century gave way to the topographical during the 19th century, favoring the development of surgical anatomy and surgery as a specialty. Illustrated atlases were the best training medium. Each atlas meant for its author a high vital impact. Most of the knowledge is copied from a small group of surgeons. Cartoonists were essential in turning atlases into works of art. Each country evolves to a surgery with different aspects. Hernia pathology is basic in the development of surgery. A great anatomical variability in the groin and abdominal wall is demonstrated. [ABSTRACT FROM AUTHOR]

Introducción. Las vías clínicas son planes asistenciales sistematizados para determinados procesos hospitalarios, que constituyen una herramienta que coordina a múltiples profesionales implicados en un objetivo común. La abdominoplastia es una de las operaciones que con mayor frecuencia practican el cirujano plástico y el cirujano general, pero no existe ningún consenso sobre cómo debe hacerse cuando existe una hernia incisional o quirúrgica asociada. En el presente trabajo se presenta el proceso de elaboración de la vía clínica del proceso “hernia incisional y abdominoplastia”. Metodología. La elaboración de la vía clínica se ha llevado a cabo mediante reuniones semanales durante tres meses. El grupo implicado ha estado formado por cirujanos, anestesiólogos, enfermeros y coordinadores de calidad de cirugía y enfermería. Se hizo un análisis de una serie previa y, además, una revisión bibliográfica con gradación de la evidencia científica, tanto del proceso “hernia incisional”, como de otras vías clínicas publicadas. Con ello, se elaboraron los documentos principales de la vía clínica, los cuales se discutieron con los miembros del servicio de cirugía y las unidades de enfermería. Resultados. Se presentan todos los documentos y protocolos de asistencia previos y posteriores a la hospitalización de los pacientes con eventración. Conclusión. La eventración puede ser sistematizada en una vía clínica que pretende estandarizar los cuidados y mejorar los resultados futuros.

Introduction: In the last decade, groin pain has become the main complication of hernioplasty and a major public health problem. This problem can only be controlled by ensuring adequate knowledge of lumbar neuroanatomy. The objective of this work is to review the history of inguinal neuroanatomy in relation to hernia pathology and the specialty of the abdominal wall. Method: Literature review of PubMed, LILACS, Cochrane Library databases; supplementary search using Google (Google Play), of university libraries. As keywords have been used: “lumbar plexus”, “inguinal nerves”, “ilioinguinal nerve”, “iliohipogastric nerve”, “genitocrural nerve”, “hernia”, “anatomy” and “surgery”. A critical analysis of published articles, theses, books and monographs is carried out. Manuscripts obtained from any country, by any institution or researcher and in any language, without time limit, are stored in pdf format. Results: The study of the history of the inguinal nerves with current methodology shows the succession of knowledge until reaching the current anatomical terminology and in parallel, the development of surgical techniques until neural pathology is considered of interest. Conclusions: Schmidt’s study offers us the most recognized descriptive topography with the first advice on clinical problems associated with neural injury during a hernia operation. His classification is the one adopted as official anatomical terminology. The concepts of the intramuscular plexus of the psoas and the iliac fossa anastomotic system were introduced by the Spaniard Gómez Durán (1923). A clear disconnection between the advances in hernia and neural anatomical-surgical knowledge is demonstrated, with a delay of two centuries in its topographical application to the abdominal wall specialty. [ABSTRACT FROM AUTHOR]

Introduction: The history of hernias has been transmitted based on the possibilities of each era, socio-economic and cultural conditions. The objective of this work is to update the history of hernia illustration, from an international or country perspective and of surgical development. Method: Literature review of PubMed, LILACS, Cochrane Library databases; supplementary search using Google (Google play), of university libraries, by bookstores (Archiveorg., Boston Medical Library and Medical Heritage Library) and in networks on antiquarian pages. As keywords have been used: “hernia”, “anatomy” and “surgery”. A critical analysis of published articles, theses, books and monographs is carried out. Manuscripts obtained from any country, by any institution or researcher and in any language, without time limit, are stored in PDF format. Results: The study of the history of hernias with current methodology has discovered new contributions in Holland and Germany. The history of the English and French texts is the best known. Gimbernat’s Spanish contribution is valued, demonstrating the necessary union between topographic anatomy and surgery, being him the first surgeon to use the term “surgical anatomy” and the true father of modern hernia surgery. Andreas Bonn’s atlas for the Dutch school, 6 years before Cooper’s, is the first and complete visual approach to the specialty with 20 lithographs (1773-1798). Conclusions: The forgotten legacy of Adam K. Hesselbach, son of Frank, with 3 major works on diagnosis and treatment (1819, 1821 and 1829) and an atlas of 20 plates (1840) made by his brother Sebastian, is the German example of the relationship between surgeon-painter brothers. The importance of the Langenbecks (uncle and nephew) as a reflection of the development of surgical science and of hernia as the basis of learning for all surgeons. The contribution of the von Froriep family, as surgeons and editors, summarizing all the anatomical and surgical knowledge of the hernia learned in previous centuries and facilitating the training of surgeons in their own language. [ABSTRACT FROM AUTHOR]