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Data compression continues to evolve, with traditional information theory methods being widely used for compressing text, images, and videos. Recently, there has been growing interest in leveraging Generative AI for predictive compression techniques. This paper introduces a lossless text compression approach using a Large Language Model (LLM). The method involves two key steps: first, prediction using a dense neural network architecture, such as a transformer block; second, compressing the predicted ranks with standard compression algorithms like Adaptive Huffman, LZ77, or Gzip. Extensive analysis and benchmarking against conventional information-theoretic baselines demonstrate that neural compression offers improved performance.

Mathematical modelling has served a central role in studying how infectious disease transmission manifests at the population level. These models have demonstrated the importance of population-level factors like social network heterogeneity on structuring epidemic risk and are now routinely used in public health for decision support. One barrier to broader utility of mathematical models is that the existing canon does not readily accommodate the social determinants of health as distinct, formal drivers of transmission dynamics. Given the decades of empirical support for the organizational effect of social determinants on health burden more generally and infectious disease risk more specially, addressing this modelling gap is of critical importance. In this study, we build on prior efforts to integrate social forces into mathematical epidemiology by introducing several new metrics, principally structural causal influence (SCI). Here, SCI leverages causal analysis to provide a measure of the relative vulnerability of subgroups within a susceptible population, which are crafted by differences in healthcare, exposure to disease, and other determinants. We develop our metrics using a general case and apply it to specific one of public health importance: Hepatitis C virus in a population of persons who inject drugs. Our use of the SCI reveals that, under specific parameters in a multi-community model, the "less vulnerable" community may sustain a basic reproduction number below one when isolated, ensuring disease extinction. However, even minimal transmission between less and more vulnerable communities can elevate this number, leading to sustained epidemics within both communities. Summarizing, we reflect on our findings in light of conversations surrounding the importance of social inequalities and how their consideration can influence the study and practice of mathematical epidemiology., Comment: 8 figures, 8 tables

Let $\eta_{1}\ge \eta_{2}\ge\cdots\ge \eta_{n}$ be the eigenavalues of $\mathcal{ABS}$ matrix. In this paper, we characterize connected graphs with $\mathcal{ABS}$ eigenvalue $\eta_{n}>-1$. As a result, we determine all connected graphs with exactly two distinct $\mathcal{ABS}$ eigenvalues. We show that a connected bipartite graph has three distinct $\mathcal{ABS}$ eigenvalues if and only if it is a complete bipartite graph. Furthermore, we present some bounds for the $\mathcal{ABS}$ spectral radius (resp. $\mathcal{ABS}$ energy) and characterize extremal graphs. Also, we obtain a relation between $\mathcal{ABC}$ energy and $\mathcal{ABS}$ energy. Finally, the chemical importance of $\mathcal{ABS}$ energy is investigated and it shown that the $\mathcal{ABS}$ energy is useful in predicting certain properties of molecules.

We propose a lesion-aware graph neural network (LEGNet) to predict language ability from resting-state fMRI (rs-fMRI) connectivity in patients with post-stroke aphasia. Our model integrates three components: an edge-based learning module that encodes functional connectivity between brain regions, a lesion encoding module, and a subgraph learning module that leverages functional similarities for prediction. We use synthetic data derived from the Human Connectome Project (HCP) for hyperparameter tuning and model pretraining. We then evaluate the performance using repeated 10-fold cross-validation on an in-house neuroimaging dataset of post-stroke aphasia. Our results demonstrate that LEGNet outperforms baseline deep learning methods in predicting language ability. LEGNet also exhibits superior generalization ability when tested on a second in-house dataset that was acquired under a slightly different neuroimaging protocol. Taken together, the results of this study highlight the potential of LEGNet in effectively learning the relationships between rs-fMRI connectivity and language ability in a patient cohort with brain lesions for improved post-stroke aphasia evaluation., Comment: Accepted at MICCAI 2024 International Workshop on Machine Learning in Clinical Neuroimaging (MLCN)

Purpose: Estimation of multi-compartment intravoxel flow in fD in ml/100g/min with multi-b-value diffusion weighted imaging and a multi-Gaussian model in the kidneys. Theory and Methods: A multi-Gaussian model of intravoxel flow using water transport time to quantify fD is presented and simulated. Multi-compartment anisotropic DWI signal is simulated analyzed with (1) a rigid bi-exponential, (2) a rigid tri-exponential, and (3) diffusion spectrum imaging model of intravoxel incoherent motion (spectral diffusion). The application is demonstrated in a two-center study of 54 kidney allografts with 9 b-value advanced DWI that were split by function (CKD-EPI 2021 eGFR<45ml/min/1.73m2) and fibrosis (Banff 2017 interstitial fibrosis and tubular atrophy score 0-6). Results: Spectral diffusion demonstrated strong correlation to truth for simulated three-compartment anisotropic diffusion (y=1.08x+0.1, R2=0.71) and two-compartment anisotropic diffusion (y=0.91x+0.6, R2=0.74), outperforming rigid models in cases of variable compartment number. Use of a fixed regularization parameter set to {\lambda}=0.1 increased computation up to 208-fold and agreed with voxel-wise cross-validated regularization (concordance correlation coefficient=0.99). Spectral diffusion of renal allografts showed significant increase in tissue parenchyma compartment fD (f-stat=3.86, p=0.02). Tubular fD was significantly decreased in allografts with impaired function (Mann-Whitney Utest t-stat=-2.14, p=0.04). Conclusions: Quantitative multi-compartment intravoxel flow can be estimated in ml/100g/min with fD from multi-Gaussian diffusion, even with moderate anisotropy such as in kidneys. The use of spectral diffusion with a multi-Gaussian model and a fixed regularization parameter shows promise in organs such as the kidney with variable numbers of physiologic compartments.

On the advent of the slow death of Moore's law, the silicon industry is moving towards a new era of chiplets. The automotive industry is experiencing a profound transformation towards software-defined vehicles, fueled by the surging demand for automotive compute chips, expected to reach 20-22 billion by 2030. High-performance compute (HPC) chips become instrumental in meeting the soaring demand for computational power. Various strategies, including centralized electrical and electronic architecture and the innovative Chiplet Systems, are under exploration. The latter, breaking down System-on-Chips (SoCs) into functional units, offers unparalleled customization and integration possibilities. The research accentuates the crucial open Chiplet ecosystem, fostering collaboration and enhancing supply chain resilience. In this paper, we address the unique challenges that arise when attempting to leverage chiplet-based architecture to design a holistic silicon solution for the automotive industry. We propose a throughput-oriented micro-architecture for ADAS and infotainment systems alongside a novel methodology to evaluate chiplet architectures. Further, we develop in-house simulation tools leveraging the gem5 framework to simulate latency and throughput. Finally, we perform an extensive design of thermally-aware chiplet placement and develop a micro-fluids-based cooling design.

Chiral molecule sensing is currently performed using chromatography, electrophoresis, enzymatic-assays, mass spectrometry, and chiroptical sensing techniques. Currently polarimetry is the only method having in-vivo sensing capabilities, while other techniques analyze chiral molecules in body fluids. Polarimetry demonstrated in-vivo performance upto depths of 1 mm while using UV-Visbile light, beyond which light scattering tends to be dominant. We hypothesize that photoacoustic sensing while operating at the Near-Infrared (NIR)-II window can allow for deep-tissue sensing, due to reduced scattering/autofluorescence effects. Herein, a Photoacoustic based Polarization Enhanced Optical Rotation Sensing (PAPEORS) system was developed for the first time to estimate optical rotation parameter using the recorded PA signals at larger depths. This optical rotation was then used to correlate with the chiral molecular concentration at depths of about 3.5 mm. Experimental evaluations were performed with aqueous glucose solution, naproxen drug, and serum-based glucose samples. PAPEORS has achieved a detection limit of 80 mg/dL using circular incidence polarization with serum-based glucose samples. Further ex-vivo experiments were performed to demonstrate the ability of PAPEORS for deep-tissue sensing, which can be extended for in-vivo chiral molecular sensing. PAPEORS uses single wavelength for sensing chiral biomolecules, hence can be miniaturized, allowing for many point-of-care applications., Comment: 30 pages, 5 figures

Detector studies for future experiments rely on advanced software tools to estimate performance and optimize their design and technology choices. The Key4hep project provides a flexible turnkey solution for the full experiment life-cycle based on established community tools such as ROOT, Geant4, DD4hep, Gaudi, podio and spack. Members of the CEPC, CLIC, EIC, FCC, and ILC communities have joined to develop this framework and have merged, or are in the progress of merging, their respective software environments into the Key4hep stack. These proceedings will give an overview over the recent progress in the Key4hep project: covering the developments towards adaptation of state-of-the-art tools for simulation (DD4hep, Gaussino), track and calorimeter reconstruction (ACTS, CLUE), particle flow (PandoraPFA), analysis via RDataFrame, and visualization with Phoenix, as well as tools for testing and validation., Comment: Proceedings of CHEP 2023

Productive and efficient human-robot teaming is a highly desirable ability in service robots, yet there is a fundamental trade-off that a robot needs to consider in such tasks. On the one hand, gaining information from communication with teammates can help individual planning. On the other hand, such communication comes at the cost of distracting teammates from efficiently completing their goals, which can also harm the overall team performance. In this study, we quantify the cost of interruptions in terms of degradation of human task performance, as a robot interrupts its teammate to gain information about their task. Interruptions are varied in timing, content, and proximity. The results show that people find the interrupting robot significantly less helpful. However, the human teammate's performance in a secondary task deteriorates only slightly when interrupted. These results imply that while interruptions can objectively have a low cost, an uninformed implementation can cause these interruptions to be perceived as distracting. These research outcomes can be leveraged in numerous applications where collaborative robots must be aware of the costs and gains of interruptive communication, including logistics and service robots., Comment: Preprint of a paper accepted for publication in Humanoids 2023 (https://2023.ieee-humanoids.org/)

Noninvasive brain stimulation (NIBS) encompasses transcranial stimulation techniques that can influence brain excitability. These techniques have the potential to treat conditions like depression, anxiety, and chronic pain, and to provide insights into brain function. However, a lack of standardized reporting practices limits its reproducibility and full clinical potential. This paper aims to foster interinterdisciplinarity toward adopting Computer Science Semantic reporting methods for the standardized documentation of Neuroscience NIBS studies making them explicitly Findable, Accessible, Interoperable, and Reusable (FAIR). In a large-scale systematic review of 600 repetitive transcranial magnetic stimulation (rTMS), a subarea of NIBS, dosages, we describe key properties that allow for structured descriptions and comparisons of the studies. This paper showcases the semantic publishing of NIBS in the ecosphere of knowledge-graph-based next-generation scholarly digital libraries. Specifically, the FAIR Semantic Web resource(s)-based publishing paradigm is implemented for the 600 reviewed rTMS studies in the Open Research Knowledge Graph., Comment: 8 pages, 2 figures. Accepted as a Practice Paper at The 25th International Conference on Asia-Pacific Digital Libraries (ICADL 2023) https://icadl.net/icadl2023/index.html#accepted