1. iPSC for modeling neurodegenerative disorders
- Author
-
A. Cota-Coronado, O.R. Hernández-Pérez, Néstor F. Díaz, Pavel H. Lugo-Fabres, N. Emmanuel Díaz-Martínez, Valeria Valadez-Barba, and Eduardo Padilla-Camberos
- Subjects
0301 basic medicine ,Neurodegenerative diseasaes ,MHC, Mayor Histocompatibility Complex ,Review ,Disease ,BBB, Blood Brain Barrier ,CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats ,Human health ,0302 clinical medicine ,B-III-TUB, β–III–Tubulin ,TH, Tyrosine Hydroxylase ,Medicine ,PCR, Polymerase Chain Reaction ,Parkinson ,Induced pluripotent stem cell ,lcsh:R5-920 ,hESC, Human Embryonic Stem Cells ,lcsh:Cytology ,iPSCs, Induced Pluripotent Stem Cells ,EBs, Embryoid Bodies ,PD, Parkinson's Disease ,gRNA, guide RNA ,nsSNVs, nonsynonymous single nucleotide variants ,DOPAL, 3,4-Dihydroxyphenylacetaldehyde ,FLASH, Fast Length Adjustment of Short Reads ,AD, Alzheimer's disease ,lcsh:Medicine (General) ,Biomedical Engineering ,iPSCs ,WGS, Whole Genome Sequencing ,Cell fate determination ,AFP, Alpha-Fetoprotein ,Biomaterials ,03 medical and health sciences ,lcsh:QH573-671 ,Aβ, β-Amyloid ,pTau, Phosphorylated Tau ,PD - Parkinson's disease ,business.industry ,SCs, Stem Cells ,SNPc, Substantia Nigra Pars Compacta ,Disease modelling ,030104 developmental biology ,LUHMES, Lund Human Mesencephalic Cell Line ,Alzheimer ,Personalized medicine ,AFP - Alpha-fetoprotein ,SMA, Smooth-Muscle Antibody ,business ,Neuroscience ,030217 neurology & neurosurgery ,ROS, Reactive Oxygen Species ,Developmental Biology - Abstract
Neurodegenerative disorders such as Parkinson's and Alzheimer's disease, are fundamental health concerns all around the world. The development of novel treatments and new techniques to address these disorders, are being actively studied by researchers and medical personnel. In the present review we will discuss the application of induced Pluripotent Stem Cells (iPSCs) for cell-therapy replacement and disease modelling. The aim of iPSCs is to restore the functionality of the damaged tissue by replacing the impaired cells with competitive ones. To achieve this objective, iPSCs can be properly differentiated into virtually any cell fate and can be strongly translated into human health via in vitro and in vivo disease modeling for the development of new therapies, the discovery of biomarkers for several disorders, the elaboration and testing of new drugs as novel treatments, and as a tool for personalized medicine., Highlights • Novel treatments to address neurodegenerative disorders. • Induced pluripotent stem cell therapy and disease modelling. • Parkinson's & Alzheimer's disease research.
- Published
- 2020