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1. Coulomb Excitation of $^{80}$Sr and the limits of the $N = Z = 40$ island of deformation

Author

Russell, R., Heery, J., Henderson, J., Wadsworth, R., Kaneko, K., Shimizu, N., Mizusaki, T., Sun, Y., Andreoiu, C., Annen, D. W., Avaa, A. A., Ball, G. C., Bildstein, V., Buck, S., Cousins, C., Garnsworthy, A. B., Gillespie, S. A., Greaves, B., Grimes, A., Hackman, G., Hughes, R. O., Jenkins, D. G., Kowalewski, T. M., Martin, M. S., Müller-Gatermann, C., Murias, J. R., Murillo-Morales, S., Pascu, S., Rhodes, D. M., Smallcombe, J., Spagnoletti, P., Svensson, C. E., Wallis, B., Williams, J., Wu, C. Y., and Yates, D.

Subjects
Nuclear Experiment, Nuclear Theory
Abstract

The region of $N\approx Z\approx 40$ has long been associated with strongly deformed nuclear configurations. The presence of this strong deformation was recently confirmed through lifetime measurements in $N\approx Z$ Sr and Zr nuclei. Theoretically, however, these nuclei present a challenge due to the vast valence space required to incorporate all deformation driving interactions. Recent state-of-the-art predictions indicate a near axial prolate deformation for $N=Z$ and $N=Z+2$ nuclei between $N=Z=36$ and $N=Z=40$. In this work we investigate the shores of this island of deformation through a sub-barrier Coulomb excitation study of the $N=Z+4$ nucleus, \textsuperscript{80}Sr. Extracting a spectroscopic quadrupole moment of $Q_s(2^+_1) = 0.45^{+0.83}_{-0.88}$~eb, we find that \textsuperscript{80}Sr is inconsistent with significant axial prolate deformation. This indicates that the predicted region of strong prolate deformation around $N=Z=40$ is tightly constrained to the quartet of nuclei: \textsuperscript{76,78}Sr and \textsuperscript{78,80}Zr., Comment: Submitted to Physics Letters B

Published
2024

2. Revealing the nature of yrast states in neutron-rich polonium isotopes

Author

Lică, R., Andreyev, A. N., Naïdja, H., Blazhev, A., Van Duppen, P., Andel, B., Algora, A., Antalic, S., Benito, J., Benzoni, G., Berry, T., Borge, M. J. G., Costache, C., Cubiss, J. G., De Witte, H., Fraile, L. M., Fynbo, H. O. U., Greenlees, P. T., Harkness-Brennan, L. J., Huyse, M., Illana, A., Jolie, J., Judson, D. S., Konki, J., Lazarus, I., Madurga, M., Marginean, N., Marginean, R., Mihai, C., Mihai, R. E., Mosat, P., Murias, J. R., Nacher, E., Negret, A., Page, R. D., Perea, A., Pucknell, V., Rahkila, P., Rezynkina, K., Sánchez-Tembleque, V., Schomacker, K., Stryjczyk, M., Sürder, C., Tengblad, O., Vedia, V., and Warr, N.

Subjects
Nuclear Experiment, Nuclear Theory
Abstract

Polonium isotopes having two protons above the shell closure at $Z=82$ show a wide variety of low-lying high-spin isomeric states across the whole chain. The structure of neutron-deficient isotopes up to $^{210}$Po ($N=126$) is well established as they are easily produced through various methods. However, there is not much information available for the neutron-rich counterparts for which only selective techniques can be used for their production. We report on the first fast-timing measurements of yrast states up to the 8$^+$ level in $^{214,216,218}$Po isotopes produced in the $\beta^-$ decay of $^{214,216,218}$Bi at ISOLDE, CERN. In particular, our new half-life value of 607(14) ps for the 8$_1^+$ state in $^{214}$Po is nearly 20 times shorter than the one available in literature and comparable with the newly measured half-lives of 409(16) and 628(25) ps for the corresponding 8$_1^+$ states in $^{216,218}$Po, respectively. The measured $B(E2;8_1^+ \to 6_1^+)$ transition probability values follow an increasing trend relative to isotope mass, reaching a maximum for $^{216}$Po. The increase contradicts the previous claims of isomerism for the $8^+$ yrast states in neutron-rich $^{214}$Po and beyond. Together with the other measured yrast transitions, the $B(E2)$ values provide a crucial test of the different theoretical approaches describing the underlying configurations of the yrast band. The new experimental results are compared to shell-model calculations using the KHPE and H208 effective interactions and their pairing modified versions, showing an increase in configuration mixing when moving towards the heavier isotopes., Comment: 6 pages, 5 figures (main manuscript), 2 pages (supplemental material)

Published
2024

6. Long and Large Stentrievers Improve Reperfusion Outcomes in Acute Intracranial Terminal Internal Carotid Artery Occlusion: Interim Results of the Rossetti Registry

Author

Lopez-Rueda, Antonio, Puig, Josep, Daunis-i-Estadella, Pepus, Werner, Mariano, González, Eva, Labayen, Ion, Vega, Pedro, Murias, Eduardo, Jimenez-Gomez, Elvira, Bravo Rey, Isabel, Moreu, Manuel, Pérez-García, Carlos, Chirife Chaparro, Oscar, Aixut, Sonia, Terceño, Mikel, Dolz, Guillem, Pumar, José Manuel, Aguilar Tejedor, Yeray, Carlos Mendez, Jose, Aparici-Robles, Fernando, Morales-Caba, Lluis, Carlos Rayón, José, San Roman, Luis, and Blasco, Jordi

Published
2024
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12. Fission of 215Fr studied with gamma spectroscopic methods

Author

Miernik, K., Korgul, A., Poklepa, W., Wilson, J. N., Charles, G., Czajkowski, S., Czyż, P., Fijałkowska, A., Fraile, L. M., Garczyński, P., Hauschild, K., Hiver, C., Kurtukian-Nieto, T., Lebois, M., Llanos, M., Lopez-Martens, A., Treasa, K. M. Deby, Ljungvall, J., Matea, I., Mielczarek, J., Murias, J. R., Pasqualato, G., Skruch, A., Solak, K., Stoyachev, K., and Tsekhanovich, I.

Subjects
Nuclear Experiment
Abstract

Background: Asymmetric fission is known to occur in two regions, the actinides and sub-lead, and is dependent on the fissioning system excitation energy. Experimental evidence in the sub-lead region show that this mode is surprisingly persistent with increasing energy and its origin is not fully understood. Purpose: To experimentally study the fusion-fission reaction of $^{215}$Fr at moderate excitation energy and determine previously unknown independent fission yields and other properties. Method: The compound nucleus was formed in the reaction $^{18}$O + $^{197}$Au. The prompt gamma-rays emitted during the reaction were measured with the high efficiency and high granularity $\nu$-ball2 spectrometer. Independent fission yields of even-even nuclei were determined by detecting triple-gamma cascades in the fission fragments. Results: The observed yields, although dominated by a symmetric peak, show maxima for heavy fragment of $Z \approx 54-56$, which is consistent with the known results in the actinide region but unexpected for the nuclide of interest, and at the studied excitation energy. Conclusions: The mode of asymmetric fission is present even at relatively high excitation energies in the system studied. This observation matches experimental findings in the sub-lead region, contrary to the actinides, and so far there is no well-developed explanation of this phenomenon.

Published
2023
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14. An innovative gamification tool to enhance intercultural competence and self-efficacy among healthcare professionals caring for vulnerable migrants and refugees

Author

Ruben Moreno-Comellas, Adria Murias-Closas, Stella Evangelidou, Lloy Wylie, and Núria Serre-Delcor

Subjects
Intercultural competence, Self-efficacy, Educational escape room, Vulnerable migrants and refugees, Healthcare education, Public aspects of medicine, RA1-1270
Abstract

Abstract Background The growing number of vulnerable migrants and refugees (VMRs) in the European Union presents challenges to healthcare systems, emphasizing the need for enhanced intercultural competence training for healthcare professionals. Educational escape rooms, using gamification-based principles, may offer an innovative solution to improve these competencies. Objective This pilot study evaluates the acceptability and preliminary effectiveness of an educational escape room aimed at improving intercultural competence, self-efficacy, and knowledge among healthcare students and professionals caring for VMRs. Methods A pre-post, single-group pilot study was conducted with 101 healthcare students and professionals, recruited through convenience sampling. Participants engaged in an educational escape room simulating a migratory crisis, designed to foster collaborative problem-solving under pressure. A newly validated questionnaire was administered before and after the intervention to measure changes in intercultural competence, self-efficacy, and knowledge. Paired t-tests were used to analyze pre-post differences, and thematic analysis explored participant feedback on the learning experience and the acceptability of the intervention. Results Significant improvements were observed in intercultural competence (d = 1.13, p

Published
2024
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18. Flow starvation during square-flow assisted ventilation detected by supervised deep learning techniques

Author

de Haro, Candelaria, Santos-Pulpón, Verónica, Telías, Irene, Xifra-Porxas, Alba, Subirà, Carles, Batlle, Montserrat, Fernández, Rafael, Murias, Gastón, Albaiceta, Guillermo M., Fernández-Gonzalo, Sol, Godoy-González, Marta, Gomà, Gemma, Nogales, Sara, Roca, Oriol, Pham, Tai, López-Aguilar, Josefina, Magrans, Rudys, Brochard, Laurent, Blanch, Lluís, and Sarlabous, Leonardo

Published
2024
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19. Commissioning of miniBELEN-10A, a moderated neutron counter with a flat efficiency for thick-target neutron yields measurements

Author

Mont-Geli, N, Tarifeño-Saldivia, A, Fraile, L M, Viñals, S, Perea, A, Pallàs, M, Cortés, G, Garcia, G, Nácher, E, Tain, J L, Alcayne, V, Alonso-Sañudo, O, Algora, A, Balibrea-Correa, J, Benito, J, Borge, M J G, Briz, J A, Calviño, F, Cano-Ott, D, De Blas, A, Domingo-Pardo, C, Fernández, B, Garcia, R, Gómez-Camacho, J, González-Romero, E M, Guerrero, C, Lerendegui-Marco, J, Llanos, M, Martínez, T, Martínez-Nouvilas, V, Mendoza, E, Murias, J R, Orrigo, S E A, de Rada, A Pérez, Pesudo, V, Plaza, J, Quesada, J M, Sánchez, A, Sánchez-Tembleque, V, Santorelli, R, Tengblad, O, Udías, J M, and Villamarín, D

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract

miniBELEN-10A is a modular and transportable moderated neutron counter with a nearly flat detection efficiency up to 8 MeV. The detector was designed to carry out measurements of (alpha, n) reactions in the context of the Measurement of Alpha Neutron Yields (MANY) project. In this work we present the results of the commissioning of miniBELEN-10A using the relatively well-known thick-target neutron yields from 27Al(alpha, n)30P.

Published
2023

20. miniBELEN: a modular neutron counter for (alpha,n) reactions

Author

Mont-Geli, N, Tarifeño-Saldivia, A, Fraile, L M, Viñals, S, Perea, A, Pallàs, M, Cortés, G, Nácher, E, Tain, J L, Alcayne, V, Algora, A, Balibrea-Correa, J, Benito, J, Borge, M J G, Briz, J A, Calviño, F, Cano-Ott, D, De Blas, A, Domingo-Pardo, C, Fernández, B, Garcia, R, García, G, Gómez-Camacho, J, González-Romero, E M, Guerrero, C, Lerendegui-Marco, J, Llanos, M, Martínez, T, Mendoza, E, Murias, J R, Orrigo, S E A, de Rada, A Pérez, Pesudo, V, Plaza, J, Quesada, J M, Sánchez, A, Sánchez-Tembleque, V, Santorelli, R, Tengblad, O, Udías, J M, and Villamarín, D

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract

miniBELEN is a modular and transportable neutron moderated counter with a nearly flat neutron detection efficiency up to 10 MeV. Modularity implies that the moderator can be reassembled in different ways in order to obtain different types of response. The detector has been developed in the context of the Measurement of Alpha Neutron Yields (MANY) collaboration, which is a scientific effort aiming to carry out measurements of (alpha,n) production yields, reaction cross-sections and neutron energy spectra. In this work we present and discuss several configurations of the miniBELEN detector. The experimental validation of the efficiency calculations using 252Cf sources and the measurement of the 27Al(alpha,n)30P reaction is also presented., Comment: 15th International Conference on Nuclear Data for Science and Technology (ND2022)

Published
2023
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22. Greater Relative First and Second Lactate Thresholds in Females Compared With Males: Consideration for Exercise Prescription.

Author

Benítez-Muñoz, José Antonio, Rojo-Tirado, Miguel Ángel, Benito Peinado, Pedro José, Murias, Juan M., González-Lamuño, Domingo, and Cupeiro, Rocío

Subjects
EXERCISE physiology, ANAEROBIC threshold, RESEARCH funding, BODY mass index, SEX distribution, EXERCISE intensity, ERGOMETRY, DESCRIPTIVE statistics, HEART beat, CYCLING, LACTATES, PHYSICAL fitness, BODY movement, COMPARATIVE studies, EXERCISE tests, OXYGEN consumption, PHYSICAL activity
Abstract

Purpose: To investigate differences between females and males at lactate thresholds 1 (LT1) and 2 (LT2). Methods: Twenty-four female and twenty male participants performed an incremental cycle-ergometer test until exhaustion, where LT1 and LT2 were determined in each volunteer. Results: Power output at LT1 and LT2 was lower in females than in males (P <.001). In addition, power output relative to peak power was higher in females at LT1 and LT2 (P <.001). However, heart rate was higher in females than males at LT1 and LT2 (P =.008). Furthermore, the heart rate relative to maximal heart rate was higher in females compared with males at LT1 and LT2 (P =.002). Conclusion: Females and males may be in a different metabolic situation at the same percentage of maximum. This study helps to reduce sex bias in science, and future guidelines should consider establishing exercise prescription recommendations according to sex. Clinical Trial: NCT06104150. [ABSTRACT FROM AUTHOR]

Published
2025
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27. Associations between Executive Function and Attention Abilities and Language and Social Communication Skills in Young Autistic Children

Author

Howard, Jill, Herold, Brianna, Major, Samantha, Leahy, Caroline, Ramseur, Kevin, II, Franz, Lauren, Deaver, Megan, Vermeer, Saritha, Carpenter, Kimberly L. H., Murias, Michael, Huang, Wei Angel, and Dawson, Geraldine

Abstract

Although it has been found that autistic children exhibit delays in executive function abilities and atypical patterns of attention, less is known about the relationship between executive function and attention abilities and social and language skills in early childhood. In this study, 180 autistic children, age 2-8 years, participated in a study examining the relationship between executive function abilities, measured by the Behavior Rating Inventory of Executive Function, and assessments of sustained attention measured via eye-tracking and several language and social communication measures. Results revealed that children with higher caregiver-reported executive function skills, specifically, working memory and planning/organization abilities, demonstrated higher levels of caregiver-reported receptive-expressive social communication abilities measured via the Pervasive Developmental Disorder Behavior Inventory. Higher executive function abilities across all domains were associated with lower levels of social pragmatic problems. Children who were able to sustain their attention for a longer duration demonstrated higher expressive language abilities. These results suggest that executive function and attention skills may play an important role in multiple domains of functioning in autistic children. It will be useful to determine whether therapies that seek to improve executive function skills in autistic individuals also positively influence their social/communication and language abilities.

Published
2023
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31. The Relationship between Cortical Thickness and Executive Function Measures in Children with and without ADHD

Author

Elana Sarabin, Kelsey Harkness, and Kara Murias

Abstract

Objective: Attention Deficit Hyperactivity Disorder (ADHD) is characterized by inattention, hyperactivity, and impulsivity; however, other executive function dysregulation is common, including inhibition and working memory. This study aims to identify CT differences based on executive function performance in individuals with and without ADHD. Methods: Data for this study was acquired from the Adolescent Brain and Cognitive Development (ABCD) database (61 ADHD, and 61 age and sex matched controls). General linear models were used to assess relationships between measures, CT, and diagnosis. Results: We found a significant relation between CT and working memory scores in the right precentral area. Additionally, we found significant interactions between CT, diagnosis, and measure outcome in the Flanker assessment (in the left fusiform area) and the attention score of the CBCL (in the right precentral region). Conclusion: This suggests that there may be different relationships that exist between CT and executive function in children with ADHD.

Published
2023
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32. Attention Allocation during Exploration of Visual Arrays in ASD: Results from the ABC-CT Feasibility Study

Author

Tsang, Tawny, Naples, Adam J., Barney, Erin C., Xie, Minhang, Bernier, Raphael, Dawson, Geraldine, Dziura, James, Faja, Susan, Jeste, Shafali Spurling, McPartland, James C., Nelson, Charles A., Murias, Michael, Seow, Helen, Sugar, Catherine, Webb, Sara J., Shic, Frederick, and Johnson, Scott P.

Abstract

Visual exploration paradigms involving object arrays have been used to examine salience of social stimuli such as faces in ASD. Recent work suggests performance on these paradigms may associate with clinical features of ASD. We evaluate metrics from a visual exploration paradigm in 4-to-11-year-old children with ASD (n = 23; 18 males) and typical development (TD; n = 23; 13 males). Presented with arrays containing faces and nonsocial stimuli, children with ASD looked less at (p = 0.002) and showed fewer fixations to (p = 0.022) faces than TD children, and spent less time looking at each object on average (p = 0.004). Attention to the screen and faces correlated positively with social and cognitive skills in the ASD group (ps < 0.05). This work furthers our understanding of objective measures of visual exploration in ASD and its potential for quantifying features of ASD.

Published
2023
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33. Atypical Tactile Perception in Early Childhood Autism

Author

Espenhahn, Svenja, Godfrey, Kate J., Kaur, Sakshi, McMorris, Carly, Murias, Kara, Tommerdahl, Mark, Bray, Signe, and Harris, Ashley D.

Abstract

We assessed different aspects of tactile perception in young children (3-6 years) with autism. Autistic and neurotypical children completed vibrotactile tasks assessing reaction time, amplitude discrimination (sequential and simultaneous) and temporal discrimination (temporal order judgment and duration discrimination). Autistic children had elevated and more variable reaction times, suggesting slower perceptual-motor processing speed and/or greater distractibility. Children with autism also showed higher amplitude discrimination and temporal order judgement thresholds compared to neurotypical children. Tactile perceptual metrics did not associate with social or tactile sensitivities measured by parent-reports. Altered tactile behavioral responses appear in early childhood, can be quantified but appear dissociated from sensitivity. This implies these measures are complementary, but not necessarily related, phenomena of atypical tactile perception in autism.

Published
2023
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34. Collectivity at the prolate-oblate transition: The 21+ lifetime of 190W

Author

E. Şahin, V. Werner, A.K. Mistry, M. Rudigier, K. Nomura, J. Jolie, N. Pietralla, P.H. Regan, G. Ağgez, H.M. Albers, U. Ahmed, Ö. Aktaş, A. Algora, S. Alhomaidhi, C. Appleton, T. Arıcı, M. Armstrong, A. Banerjee, J. Benito, G. Benzoni, A. Blazhev, P. Boutachkov, A.M. Bruce, B. Cederwall, M.M.R. Chishti, M.L. Cortés, F. Crespi, B. Das, T. Davinson, T. Dickel, M. Doncel, A. Ertoprak, A. Esmaylzadeh, L.M. Fraile, E.R. Gamba, J. Gerl, M. Górska, J. Ha, E. Haettner, O. Hall, H. Heggen, C. Hornung, N. Hubbard, S. Jazrawi, P.R. John, C.E. Jones, V. Karayonchev, E. Kazantseva, R. Kern, L. Knafla, I. Kojouharov, P. Koseoglou, G. Kosir, D. Kostyleva, N. Kurz, N. Kuzminchuk, M. Llanos-Expósito, R. Lozeva, D. Mengoni, T.J. Mertzimekis, M. Mikolajczuk, A.I. Morales, I. Mukha, J.R. Murias, B.S. Nara-Singh, S.E.A. Orrigo, J. Pellumaj, S. Pelonis, S. Pietri, S. Pigliapoco, Zs. Podolyák, M. Polettini, K. Rezynkina, H.A. Rösch, H. Schaffner, Ch. Scheidenberger, L. Sexton, P.-A. Söderström, Y.K. Tanaka, J.J. Valiente-Dobón, P. Vasileiou, J. Vasiljević, J. Vesic, H. Weick, J. Wiederhold, A. Yaneva, G. Zhang, J. Zhao, and A. Zyriliou

Subjects
Nuclear structure, γ-ray spectroscopy, Isomer spectroscopy, Shape phase transition, DESPEC, NUSTAR, Physics, QC1-999
Abstract

The neutron-rich rare isotope 190W is discussed as a candidate for a prolate-oblate transitional nucleus with maximum γ-softness. The collectivity of this isotope is assessed for the first time by the measurement of the reduced E2 transition probability of its first 2+ state to the ground state. The experiment employed the FAst TIming Array (FATIMA), comprised of 36 LaBr3(Ce) scintillators, which was part of the DESPEC setup at GSI, Darmstadt. The 41+ and 21+ states of 190W were populated subsequently to the decay of its 127(12) μs isomeric Jπ=10− state. The mean lifetime of the 21+ state was determined to be τ=274(28) ps, which corresponds to a B(E2;21+→01+) value of 95(10) W.u. The results motivated a revision of previous calculations within an energy-density functional-based interacting boson model-2 approach, yielding E2 transition properties and spectroscopic quadrupole moments for tungsten isotopes. From comparison to theory, the new data suggest that 190W is at the transition from prolate to oblate structure along the W isotopic chain, which had previously been discussed as a nuclear shape-phase transition.

Published
2024
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36. Novel BODIPY Dyes with a Meso-Benzoxadiazole Substituent: Synthesis, Photophysical Studies, and Cytotoxic Activity Under Normoxic and Hypoxic Conditions

Author

Weronika Porolnik, Natalia Karpinska, Marek Murias, Jaroslaw Piskorz, and Malgorzata Kucinska

Subjects
anticancer research, benzofurazan, BODIPY, halogenation, heavy atom effect, hypoxia, Biology (General), QH301-705.5
Abstract

Background/Objectives: Novel boron dipyrromethene derivatives with a heterocyclic, benzoxadiazole substituent were obtained as potential candidates for the photodynamic therapy (PDT) of cancers. Photochemical properties (e.g., singlet oxygen generation quantum yields (ΦΔ), absorption, and emission spectra) and cytotoxic activity studies in normoxic and hypoxic conditions were performed to verify the potential of novel BODIPYs as photosensitizers for PDT. Methods: Obtained dyes were characterized using mass spectrometry and various NMR techniques. The relative method with Rose Bengal as a reference and 1,3-diphenylisobenzofuran as a singlet oxygen quencher was used to determine ΦΔ values. The in vitro studies were conducted on human ovarian carcinoma (A2780) and human breast adenocarcinoma (MDA-MB-231) cells. Results: Photochemical studies showed that the presence of benzoxadiazole moiety only slightly affected the localization of the absorption maxima but resulted in fluorescence quenching compared with meso-phenyl-substituted analogs. In addition, brominated and iodinated analogs revealed a high ability to generate singlet oxygen. Anticancer studies showed high light-induced cytotoxicity of BODIPYs containing heavy atoms with very low IC50 values in the 3.5–10.3 nM range. Further experiments revealed that both compounds also demonstrated phototoxic activity under hypoxic conditions. The most potent cytotoxic effect in these conditions was observed in the iodinated BODIPY analog with IC50 values of about 0.3 and 0.4 μM for A2780 and MDA-MB-231 cells, respectively. Conclusions: The results of this study highlighted the advantages and some potential drawbacks of BODIPY compounds with heavy atoms and benzoxadiazole moiety as a useful scaffold in medicinal chemistry for designing new photosensitizers.

Published
2025
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37. Insights into the Mode of Action of Novel Morpholinated Curcumin Derivatives Exhibiting Potent Antitumor Activity in Bladder Cancer Cells In Vitro

Author

Paulina Kobylka, Pawel Bakun, Joanna Kuzminska, Tomasz Goslinski, Marek Murias, and Malgorzata Kucinska

Subjects
curcumin, curcumin derivatives, apoptosis, bladder cancer, hypoxia, cancer research, Organic chemistry, QD241-441
Abstract

Although curcumin is a well-known natural polyphenol with many biological activities, its clinical application has been limited by low aqueous solubility and stability. Therefore, curcumin derivatives have been proposed to overcome these limitations and increase anticancer activity. This study tested curcumin derivatives with modified feruloyl moieties (2a and 2a-B) and the β-diketo moiety (2a-B) to better understand their anticancer mechanism against human bladder cancer cells. The anticancer activity of 2a and 2a-B was determined using MTT (hypoxic conditions) and LDH (normoxic conditions) assays. An ELISA-based protein panel was used to find the potential molecular targets, while flow cytometric, colorimetric, fluorescent, and luminescent assays were used to investigate the cell death mechanism. It was shown that compound 2a exerted a more potent cytotoxic effect under hypoxic conditions, while compound 2a-B demonstrated a comparable effect in normoxic and hypoxic conditions. The potential molecular targets modified by 2a and 2a-B depending on oxygen concentration were also proposed. Both compounds alter cell cycle progression by blocking the cell cycle in the G2/M phase and decreasing the percentage of cells in the G0/G1 phase. Compound 2a-B led to phosphatidylserine translocation, increased caspase 3/7 activity, and decreased mitochondrial membrane potential, suggesting a mitochondrial apoptosis pathway. We found that the Akt signaling pathway may modulate the activity of compound 2a-B, as evidenced by enhanced cytotoxic activity in combination with MK-2206, an Akt 1/2/3 inhibitor. Thus, our results provide new insights into the anticancer activity of compounds 2a and 2a-B; however, further studies are needed to better understand their therapeutic potential.

Published
2025
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38. Improving the Agreement Between the First Heart-Rate-Variability Threshold and the Gas-Exchange Threshold.

Author

Rogers, Bruce, Fleitas-Paniagua, Pablo R., and Murias, Juan M.

Subjects
PEARSON correlation (Statistics), HEART rate monitoring, PULMONARY gas exchange, ANAEROBIC threshold, DESCRIPTIVE statistics, HEART beat, RESPIRATORY measurements, EXERCISE tests, OXYGEN consumption, COMPARATIVE studies, DATA analysis software
Abstract

Purpose: The first heart-rate (HR) -variability (HRV) -derived threshold based on detrended fluctuation analysis alpha 1 (DFA a1) has shown inconsistent agreement with the gas-exchange threshold (GET). This study examined whether a custom method of computing the first HRV threshold (HRVT1) based on individual HRV characteristics would improve agreement. Methods: Fourteen participants underwent ramp incremental testing measuring gas-exchange variables and RR intervals. Comparisons were made between the oxygen consumption (V ˙ O 2) / HR at the GET versus the V ˙ O 2 / HR at the standard DFA a1 = 0.75 (HRVT1s) or a custom value (HRVT1c) based on the DFA a1 midway between the maximum seen during the early ramp incremental and 0.5. Results: Mean values for GET V ˙ O 2 versus HRVT1s V ˙ O 2 and GETHR versus HRVT1sHR were statistically different (25.4 [3.3] vs 29.8 [6.8] mL·kg−1·min−1, P =.01, d = 0.80; 131 [11] vs 146 [22] beats·min−1, P =.005, d = 0.91). There were no statistical differences when using the HRVT1c (25.4 [3.3] vs 25.1 [5.7] mL·kg−1·min−1, P =.77, d = 0.08; 131 [11] vs 132 [17] beats·min−1, P =.65, d = 0.12). Equivalence between GET and HRVT1c V ˙ O 2 / HR was also verified. Mean maximal DFA a1 during the early ramp incremental was 1.52 (0.22) with mean HRVT1c of 1.01 (0.11). Pearson r correlation coefficients were between.67 and.70 for all GET to HRVT1 comparisons. The second HRV threshold and respiratory compensation point parameters showed agreement and correlations in line with prior studies. Conclusions: The HRVT1c showed stronger agreement to GET parameters than seen using the HRVT1s. It is recommended that evaluations of the HRVT1 consider this approach in determining the HR and V ˙ O 2 at this threshold. [ABSTRACT FROM AUTHOR]

Published
2024
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41. Access to and quality of elective care: a prospective cohort study using hernia surgery as a tracer condition in 83 countries

Author

Dönmez, A Eylül, Goswami, Aakansha Giri, Raheja, Aashna, Bhadani, Aayush, El Kady, Abd Elrahman Safwat, Alniemi, Abdalaziz, Awad, Abdalkarim, Aladl, Abdalla, Younis, Abdalla, Alwali, Abdallah, Khalil, Abdallah, Mansour, Abdallah, Elkhouly, Abdallah Mohamed, Rashad Temerik, Abdallah, Hasan, Abdallatef, Chied, Abdelhafid, Abdraba, Abdelhamid, Hrora, Abdelmalek, Abdelshafi, Abdelrahman, Alwali, Abdelrahman, Maraqa, Abdelrahman, Ghaffar, Abdul, Chekfa, Abdul Jabar, Al Balushi, Abdul Majeed, Quddus, Abdul, Hammadieh, Abdul Rahman, Muntaka, Abdul-Jalilu Mohammed, Asekun, Abdulazeez, Alshahrani, Abdulaziz, Jowharji, Abdulaziz, Alshukre, Abdulbaset, Khair Etareig, Abdulhafid, Abubakar Abdulkarim, Abdulhafiz, Ashiru, Abdulhafiz, Alailesh, Abdulhamid, Al-Mallah, Abdullah, Baydoun, Abdullah, Chaudhry, Abdullah, Askin, Abdullah Emre, Almutairi, Abdulmjeed, Belkhair, Abdulmunem, Abdllah, Abdulrahman, Alhammali, Abdulrahman, Basalim, Abdulrahman, Abouelnagah, Abdulrahman Galal Mohamed Mostafa, Ghazal, Abdulrahman, Mohammed, Abdulrahman, Qasem, Abdulrahman, Anadani, Abdulrazak, Jimoh, Abdulrazaq, Lawal, Abdulrazzaq Oluwagbemiga, Khaity, Abdulrhman, Lawal, Abdulwahab, Elzoubi, Abdurrahim Esseid, Sheshe, Abdurrahman Abba, Cetişli, Abdurrahman Furkan, Oyedele, Abeeb, Aljahdali, Abeer, Aboelnasr, Abeer Gamal Elsyed, Demessie, Abel, Bhargava, Abhilasha, Sonkar, Abhinav Arun, Bavaharan, Abhirame, Khan, Abid, Campbell, Abigail, Oyelekan, Abimbola Adeola Akintunde, Okunlola, Abiodun Idowu, Ojewuyi, Abiodun, Ekerin, Abiola, Saleh, Abobakr, Khairy, Abouelatta, Muthunayagam, Abraham Benjamin, Botha, Abraham, Teshome Sahilemariam, Abraham, Nawawi, Abrar, Muhammad, Abubakar Bala, Dahiru, Abubakar, Yahaya, Abubakar, Abdelmalik, Abubaker, Anuar, Abul Akmal Arif, Ousseini, Adakal, Leon -Del- Angel, Adalberto, Frankel, Adam, Gyedu, Adam, Lim, Adam, Lukáč, Adam, Peckham-Cooper, Adam, Sabbah, Adam, Varga, Adam, Sanou, Adama, Issaka, Adamu, Ningi, Adamu, Yeshitila, Addis, Yingess, Addisu, Olugbami, Adebayo, Moses, Damola-Okesiji, Adebola, Lawal, Adedayo, Ojo, Adedoyin, Hashmi, Adeel, Fakoya, Adegbolahan, Ishola, Adegoke, Abiodun, Adekunle, Ajayi, Adekunle, Mouffokes, Adel, Bonelli, Adele, Adekoya, Adeleke, Akeem Aderogba, Adeleke, Özcan, Adem, Ayoade, Ademidun, Adeyeye, Ademola, Agbaje, Ademola, Talabi, Ademola, Ademuyiwa, Adesoji, Adewumiya, Adesoji, Ademuyiwa, Adesoji O, Aderounmu, Adewale, Adisa, Adewale, Oke, Adewale, Ragab, Adham, Alzadjali, Adil, Baksi, Aditya, Jayapalan, Aditya, Md Yunos, Adnan, Pisanu, Adolfo, Salazar, Adolfo, Salinas Barragan, Adrian Alberto, Fox, Adrian, Stollberg, Adrian, Franco, Adriana, Neves, Adriana, Vricheva, Adriana, Hodonou, Adrien Montcho, Aghayeva, Afag, Liaquat, Affifa, Alsultan, Afnan, Morad, Afnan, Kalidis, Afroditi Angella, Gkouniaroudi, Agathi, Karakosta, Agathi, Lovi, Agbenya, Yevide, Agossou Barthélémy, Duro, Agustin, Rodriguez Gonzalez, Agustin, Tariq, Ahbala, Abaidalla, Ahmad, Abuhammad, Ahmad, Abuhantash, Ahmad, Mansour, Ahmad Adel, Ahmad Zaidi, Ahmad Al Hafeez, Alahmad Alismael, Ahmad, Alayed, Ahmad, Alfarwan, Ahmad, Alhaj, Ahmad, Ali, Ahmad, Alroobi, Ahmad, Alsheikh, Ahmad, Alusef, Ahmad, Alzu'Bi, Ahmad, Kayali, Ahmad Amir, Bouhuwaish, Ahmad, Doghaim, Ahmad, El-Sherbiney, Ahmad, Ghazal, Ahmad, Ramly, Ahmad Nasir, Raza, Ahmad, Qureshi, Ahmad Uzair, Arnaout, Ahmad Yamen, Abdelhamid, Ahmed, Abuthaher, Ahmed, Adel, Ahmed, Ahmayda, Ahmed, Al-Mouahhed, Ahmed, Alagha, Ahmed, Albalawi, Ahmed, Albhaisi, Ahmed, Alrifaee, Ahmed, Azam, Ahmed, Barakat, Ahmed, Al-Hajjaj, Ahmed Basim Abed, Dawoud, Ahmed, El Shamarka, Ahmed, El-Bastwesy, Ahmed, Elghrieb, Ahmed, Elkhalifa, Ahmed, Elmosalamy, Ahmed, Elshazli Mahmoud, Ahmed, Montaser, Ahmed G., Gbeadese, Ahmed, Haty, Ahmed, K. 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Daniel, Montwedi, Daniel, Muñoz, Daniel, Patterson, Daniel, Reim, Daniel, Agbley, Daniel Yao Dodzie, Patiño García, Daniela Cristina, Di Pietrantonio, Daniela, Pais, Daniela, Rosado, Daniela, Tavares, Daniela, Alberti, Daniele, Fusario, Daniele, Massaro, Daniele, Paglione, Daniele, Pironi, Daniele, Kurochka, Daniil, Centonze, Danilo Corrado, Hackner, Danilo, Herrera, Danilo, Amangaliyev, Daniyar, Silva-Cano, Danny Wladimir, Chaudhry, Daoud, Palmisano, Dario, Ribero, Dario, Vukosav, Dario, Misca, Darius, Lowen, Darren, Rattray, Darren, Walia, Darshanjit Singh, Maan, Darvesh, Muyenzi, Daryle, Verdi, Daunia, Bardsley, David, Reyes Rodríguez, David Estuardo, Fra Corral, David, Garcia López De Goicoechea, David, Gavit, David, Gómez, David, Idowu, David, Konkin, David, Labadah, David Kplorla Kekeli, Liu, David, Merlini, David, Mitchell, David, Moro-Valdezate, David, Osifo, David, Proud, David, Ridder, David, Gobatti, Davide, Muschitiello, Davide, Pertile, Davide, Zulian, Davide, Mengiste, Dawit, Mikami, Dean, Mohanty, Debajyoti, Chatterjee, Debarghya, Komolafe, Deborah Olaitan, Scotto Di Carlo, Deborah, Wright, Deborah, Rahme, Deema, Talreja, Deep Parkash, Jain, Deepak, Rajput, Deepak, Singh, Deepak, Anbu, Deepika, Ibrahim, Dena, Phom, Denchu, Hili, Denise, Osei, Dennis Broni, Daary, Dennis, Kyeremeh, Dennis, Shen, Dennis, Uymaz, Derya Salim, Cianflocca, Desiree, Ashitey, Desmond, Evripidou, Despo, Papageorgouli, Despoina, Kaushal, Devesh, Abeysirigunawardana, Dewmi, Dugar, Dharmendra, Mallik, Dhiraj, Ghosh, Dhruva, Houmran, Diaa, Abdulrahman, Diala, Pantoja Pachajoa, Diana Alejandra, Cardona Gomez, Diana Catalina, Fenner, Diana, Gonzalez, Diana Samantha, Siriwardena, Diana, Garcés Palacios, Diana Sofía, Stoian, Diana, Zuikyte, Diana, Sosa Méndez, Dianne Alitzá, Wickramarathna, Dickson, Mutter, Didier, Palma Portillo, Diego Andrés, Chavez Fernandez, Diego, Córdova García, Diego, Enjuto, Diego, Giulitti, Diego, Sasia, Diego, Visconti, Diego, Yiğit, Dilara, George, Dilip, Rabaia, Dima, Georgiev, Dimitar, Hadzhiev, Dimitar, Alexandrou, Dimitrios, Balalis, Dimitrios, Giakoustidis, Dimitrios, Manatakis, Dimitrios K., Korkolis, Dimitrios, Lytras, Dimitrios, Massaras, Dimitrios, Moris, Dimitrios, Politis, Dimitrios, Sampanis, Dimitrios, Schizas, Dimitrios, Tsiardas, Dimitrios, Vardakostas, Dimitrios, Kotsaris, Dimitris, Khattab, Dina Hesham, M. Awad, Dina, Alrokh, Dina Sami, Schippers, Dina, Waleed, Dina, Salinovic, Dinko, Gonçalves Múrias Gomes, Diogo Miguel, Silva, Diogo, Vaz Acosta, Diogo, Morton, Dion, Panagopoulos, Dionisios, Kelgiorgi, Dionysia, Dellaportas, Dionysios, Prevezanos, Dionysios, Joshi, Dipti, Ozal, Direm, Yigit, Direnc, Chimkaomasiri, Divine, Jabbar, Diya, Nepogodiev, Dmitri, Belekar, Dnyanesh, Abdalaziz, Doaa, Abunemer, Doaa, Attia, Doaa, Elkafrawy, Doaa, Dimitrov, Dobromir, Pignatelli, Domenica, Merlicco, Domenico, Soriero, Domenico, Zerbo, Domenico, Atouguia, Domingas, Fairbrass, Dominic, T. Enti, Donald, Venskutonis, Donatas, Rukavina, Dora, Caruso, Dorena, Herappe, Dorihela, Lee, Dorinda Norbetha, Ofosuhene, Doris, Hajela, Apoorva, Badwan, Basem, Kulkarni, Datta, Dhawan, Deep, Dhillon, Jeevanjit, Mehmood, Manzer, Mahmood, Namrah, Nikam, Narendra, Ramchandani, Radhakrishna, Thind, Ravinder Singh, Riazhussain, D Hafiz, Maqsood, Saliha, Alalawi, Yousef, Tyagi, Harshdeep, Kshirsagar, Shivani, Ahmed, Hisham, Juan Carlos, Luna Cydejko, Kone, Dramane, Omar, Duaa, Alves, Duarte Gil, Subasinghe, Duminda, Ommi, Durgesh, Joshiba, Durshney, Chakarov, Dzhevdet, Arkoh, Ebenezer Ameyaw, Frimpong-Manso, Ebenezer, Ada, Ece, Lincango, Eddy P., Lozada Hernandez, Edgard Efren, Hodžić, Edin, Di Marco, Edith, Baccalini, Edoardo Andrea, Baldini, Edoardo, González Marín, Eduardo, Gutierrez, Eduardo, Sepúlveda, Eduardo, Dainius, Edvinas, Zhang, Edward, Yenli, Edwin Mwintiereh Ta-Ang, Antoniou, Efstathios, Kapasakis, Efstathios, Baili, Efstratia, Poulios, Efthymios, Kubiliute, Egle, Osaze, Ehioghae, Afeikhena, Ehis, Elshennawy, Eiad, Athanasopoulou, Eirini, Synekidou, Eirini, Ekaladze, Eka, Tampaki, Ekaterini Christina, Adam, Elaf, Adel Hamdoun Aziz, Elaf, Yousuf, Elamin, Gialamas, Eleftherios, Spartalis, Eleftherios, Bedzhanyan, Elen, Toma, Elena Adelina, Daukšaitė, Elena, Desiato, Elena, Dvivedi, Elena, Hadzhieva, Elena, Martí Cuñat, Elena, Montalbán Martínez, Elena, Montanari, Elena, Signaroli, Elenasofia, Efremidou, Eleni, Gavriil, Eleni, Karakeke, Eleni, Mavrodimitraki, Eleni, Papamattheou, Eleni, Jose, Elenza, Cianci, Eleonora, Ciccioli, Eleonora, Daleva, Eleonora, Locci, Eleonora, Lori, Eleonora, Silanos, Eleonora, Ayala, Elí, Bankart, Eliana, Brolese, Eliane, Efstathiou, Elias, Salloum, Elias, Colak, Elif, Terzi, Elif Didem, Ametefe, Elikem, Cagigal Ortega, Elima Pilar, Donnarumma, Elio, Mina, Elisa, Reitano, Elisa, Wallner, Elisabeth, Moggia, Elisabetta, Betz, Elise, Kontis, Elissaios, Anestiadou, Elissavet, Gimson, Eliza, Lun, Elizabeth, Fraser, Elizabeth, Li, Elizabeth, Torres De Anda, Elizabeth Magaly, Murphy, Elizabeth Mary Ann, O'Connell, Elizabeth, Redondo, Elizabeth, Lun, Elizabeth Weng Yan, Francis, Ella, Haiden, Elmar, Hamed, Elmonzir, Alkhalifa, Elmustafa, Dexter, Eloise, Daketsey, Elorm, Setsoafia, Elorm, Mohamed, Elsagad, Mohammed, Elsamoual, Hegab, Elsayed, Ay, Elvin, Adinolfi, Elvira, Mbanzabugabo, Elvis, Chin, Elynn, Ahmed, Emad Ali, Younes, Eman, Basile, Emanuela, Gessa, Emanuela, Pontecorvi, Emanuele, Romairone, Emanuele, Hatangimana, Eméry, Ndizeye, Emile, Ciofic, Emilia, Dijan, Emilio, López-Negrete Cueto, Emilio, Baker, Emily, Reid, Emily, Schmidt, Emily, Alić, Emir, Bičakčić, Emir, Agbowada, Emma, Colton, Emma, Downing, Emma, Haege, Emma, O'Neill, Emma, Roussos, Emmanouel, Nachelleh, Emmanuel Aadereyir, Adebunmi, Emmanuel, Obiesie, Emmanuel Ahuizechukwu, Akakpo, Emmanuel Bismark, Konlan, Emmanuel Dammigu Francis, Nwangwu, Emmanuel Ifeanyi, Kafui Ayodeji, Emmanuel, Ofori, Emmanuel Owusu, Spanoudakis, Emmanuel, Abate, Emmanuele, Balik, Emre, Bozdağ, Emre, Bozkurt, Emre, Karabulut, Emre Cagri, Ozoran, Emre, Tunçcan, Emre, Tuzuner, Emre, Halilović, Emsad, Alabed, Enaam, Zidan, Enas, Hodžić, Enes, Aybar, Engin, Yildirim, Engin Okan, Wong, Enoch, Yhoshu, Enono, Bisogno, Enrica, Andolfi, Enrico, Ferri, Enrico, Potenza, Enrico, Spalice, Enrico, Volpin, Enrico, González, Enrique, Downes, Eoin, Gallo, Erdachew, Kamer, Erdinc, Naidoo, Eressa, Erginöz, Ergin, Bara, Eric, Irungu, Eric, García-Villegas, Eric Yusif, Mazzotta, Erica, Monati, Erica, Chan, Erick, Gómez Mejía, Erika, Dylja, Eris, Somuncu, Erkan, Yavuz, Erkan, Begunić, Ernes, Margelis, Ernest, Osei, Ernest Owusu, Saitoglou, Ertzan, Agastra, Ervis, Mazumdar, Eshan, Soyer Güldoğan, Esra, Abu Siam, Esra'A, Abdelbaset, Esraa, Abdu, Esraa, Adel Mahmod Sultan, Esraa, Nubi Mohamed, Esraa Gamal, Abuobaida Banaga Hag El Tayeb, Essam Eldien, Ali, Essraa, Page-Taylor, Estelle, Marra, Ester, Garcia Santos, Esther Pilar, Elsheikh, Ethar, Unal, Ethem, Tan, Eugene, De Leo, Eugenio, Borges, Eva, Gáspár, Éva, Ruiz-Daum, Eva, Apostolopoulos, Evaggelos, Samara, Evangelia, Barkolias, Evangelos, Fradelos, Evangelos, Hopping, Eve, Romo Ascencio, Evelia Veronica, Sosa Ferreira, Ever David, Shestakov, Evgenii, Tyurina, Evgenya, Hristova, Evguenia, Efthymiou, Evripidis, Tokidis, Evripidis, Harrison, Ewen, Dontoh, Ewurama Akroma, Mansour, Eyad, Yeshialem, Eyosiyas, Dabbagh, Ezeddin, Amer, Ezzeldin, Manasci, Fabiana, Gomes, Fabio, Medas, Fabio, d'Acapito, Fabrizio, Vassallo, Fabrizio, Haddad, Fadi, Elhabishi, Fadwa, Akhtar, Fahad, Tauheed, Fahad, Al Abbood, Fahd, Gareb, Fahed, Ghazali, Fairuz, Alnazawi, Faisal, Ondago, Faith, Rasoaherinomenjanahary, Fanjandrainy, Wiese, Fanny, González Ponce, Fanny Yesenia, Georgiades, Fanourios, Ali, Farah, Galley, Fareeda, Huda, Farhanul, Amir, Farhat Naaz, Ashraf, Fariha, Alfarsi, Faris, Ayasra, Faris, Ali, Farman, Mahmoud, Faten, Aliskander, Fater, Tahir Lwdie, Fathea, Buyuker, Fatih, Aguilar Del Castillo, Fátima, Mohammed Daoud, Fatima Ahmed, Alowjaly, Fatima, Oni, Fatima, Rauf, Fatima, Elkhafeefi, Fatimah, Hourri, Fatine, Monib, Fatma A., Alshreef, Fatma, Benghalbon, Fatma, Ntirenganya, Faustin, Ashraf, Fauziyah, Chahrour, Fayez, Ahmad, Fazal, Parray, Fazlul Qadir, Philips, Febi, Campus, Federica, Di Marco, Federica, Ferraina, Federica, Frongia, Federica, Maffeis, Federica, Natali, Federica, Pederiva, Federica, Scolari, Federica, Tofani, Federica, Marin, Federico Alberto Niccolò, Biolchini, Federico, Cappellacci, Federico, Corronca, Federico, Mazzola, Federico, Suldrup, Federico, Nyarko, Felicia, Casas J, Felipe, Zapata, Felipe, Aigner, Felix, Alakaloko, Felix, Amoako, Felix, Camacho, Felix, Hammett, Felix, Kuubetersob B. N, Felix, Alahmad, Feras, Alnimri, Feras, Haddad, Feras, Gool, Ferhana, Castro, Fernanda, Diaz, Fernanda, Lucero, Fernanda, Vovola, Fernanda, Mahnic, Fernando, Mercado Sanchez, Fernando, Prieto La Noire, Fernando, Soggiu, Fiammetta, Tsige, Fikreab, Brzeszczyński, Filip, Rudisch, Filip, Valente Costa Pinto, Filipa, Ramalho De Almeida, Filipe, Banchini, Filippo, Palomino Escalante, Fiorella, Fadzlullah, Fitri, Terefe, Fitsum, Sulo, Fjorenta, Ciccarone, Flavia, Tirelli, Flavio, Krämer, Florian, Grama, Florin, Spanos, Foivos, Solimene, Folco, Akinwande, Foluso, Osman, Forzia, Stefou, Foteini, Kyramargios, Fotios, Stavratis, Fotios, Alassani, Fousseni, Ascari, Francesca, Cammelli, Francesca, D'Agostino, Francesca, Tropeano, Francesca Paola, Peters, Francesca, Ré, Francesca, Brucchi, Francesco, Casti, Francesco, Coratti, Francesco, Ferrara, Francesco, Floris, Francesco, Izzo, Francesco, Maffei, Francesco, Palmieri, Francesco, Pata, Francesco, Porcelli, Francesco, Selvaggi, Francesco, Velluti, Francesco, Mulita, Francesk, Bello, Francis, Caiquo, Francis, Dossou, Francis, Eshun, Francis Junior, Opoku Twene, Francis, Tierenye, Francis, Quayson, Francis William, Romo Rosales, Francisco David, Ibañez Ortiz, Francisco, León Frutos, Francisco Javier, Redondo Calvo, Francisco Javier, Silva Rivera, Francisco Javier, Barbosa Camacho, Francisco José, Bujalance Cabrera, Francisco Manuel, Ruescas, Francisco, Irakiza, Franck Fanon, Corvatta, Franco, Pascual, Franco Raúl, Roviello, Franco, Roodt, Francois, Gyamfi, Frank Enoch, Olaniru, Frank, Owusu, Frank, Bader, Franz G., Anzinger, Franz-Xaver, Agbodo, Fred David Anku, Ris, Frederic, Agbemafoh, Frederick Mawuli, Afonso, Frederico, Nazareth, Frederico, Berrevoet, Frederik, Hounde, Fréjus, Demiral, Furkan, Hassooni, Furqan Ridha Hassooni, Kafa, Gabi, Cárdenas Rivera, Gabriel, Ntwari, Gabriel, Szydlo Shein, Gabriel, Ambriz González, Gabriela, Nita, Gabriela Elisa, Bellio, Gabriele, Moitzi, Gabriele, Urdang, Gabriella, Marom, Gad, Gallo, Gaetano, Luglio, Gaetano, Poillucci, Gaetano, Singh, Gagandeep, Saletta, Gaia, Abouelnagah, Galal, Yarovenko, Galina, Kazobinka, Gallina, Ahmed, Gamal Mutwakil Gamal, Rahman, Ganiyu Adebisi, Smith, Garett, Pillai, Gargi, Saxena, Garima, Gbessi, Gaspard, Nkunguzi, Gaston, Jalal, Gaurav, Chillarge, Gauri, Singh, Gautam, Mevognon, Gedeon, Getachew, Gedion, George, Gejoe, De La Peña González, Gema, Martínez Izquierdo, Gema, Grande, Gennaro, Birikorang, Geoffrey, Weber, Georg F., Singer, Georg, Ansong, George, Bashour, George, Brown, George Darko, Hneino, George, Kavalieratos, George, Kenchadze, George, Nagy, George, Pappas Gogos, George, Skroubis, George, Waiyaki, George, Cox, Georgia, Zeringa, Georgia, De Wee, Georgin, Hart, Georgina, Bekakos, Georgios, Fragulidis, Georgios, Kapogiannatos, Georgios, Karakaidos, Georgios, Kokkinos, Georgios, Kostoulas, Georgios, Koukoulis, Georgios, Peros, Georgios, Rados, Georgios, Tsoulfas, Georgios, Verras, Georgios-Ioannis, Berger, Geraint, Adoro, Gerard Ayuka, Chamoso Mialdea, Gerardo, Palmieri, Gerardo, Procaccini, Gerardo, Steenkamp, Gerhard, Viscido, Germán Rodrigo, Dajti, Gerti, Alemayehu, Getachew, Seyfu, Gezachew, Birqeeq, Ghada, Alsheikh, Ghadeer, Alrayyes, Ghaith, El Hunjul, Ghalib Nashaat, Zaza, Ghayath, Matroud, Ghazlah, Alhadwah, Ghena, Maltinti, Gherardo, Awais, Ghina, Shamsi, Ghina, Calini, Giacomo, Carganico, Giacomo, Zanus, Giacomo, Canu, Gian Luigi, Mendiola, Gian, Ibero Casadiego, Giana Pamela, Cocorullo, Gianfranco, Baronio, Gianluca, Pellino, Gianluca, Zanni, Gianluca, Poto, Gianmario Edoardo, Gravante, Gianpiero, Aduroja, Gideon, Almogy, Gidon, Bond-Smith, Giles, Natchagande, Gilles, Bechara, Gio, Brachini, Gioia, Riccioli, Giordana, Ercolani, Giorgio, Farris, Giorgio, Giraudo, Giorgio, Mammolo, Giovanna, Pavone, Giovanna, Sgarzini, Giovanna, Aprea, Giovanni, Fonsi, Giovanni Battista, Boroni, Giovanni, De Angeli, Giovanni, De Palma, Giovanni Domenico, Emiliani, Giovanni, Grava, Giovanni, Guercio, Giovanni, De Carlo, Giulia, Del Corpo, Giulia, Duranti, Giulia, Galatioto, Giulia, Grassi, Giulia, Graziano, Giulia, Marini, Giulia Maria Francesca, Munzi, Giulia, Tarantino, Giulia, Borda-Luque, Giuliano, Pellicano', Giuseppe Antonino, Canonico, Giuseppe, Carollo, Giuseppe, Ietto, Giuseppe, Palomba, Giuseppe, Pascarella, Giuseppe, Salamone, Giuseppe, Sica, Giuseppe, Sorrentino, Giuseppe, Orlando, Giuseppina, Pignata, Giusto, Pisarevi, Givi, Akcakoca, Gizem, Owusu, Godfred, Yohanna Abrak, Godwin, Kurtoglu, Gokalp Kagan, Kurtoglugk, Gokalp Kagan, Alıcı, Gökhan, Kurtoglu, Goktug Mert, Delgado Hernandez, Gonzalo, Augustin, Goran, Bhat, Gowhar Aziz, Sundaram Venkatesan, Gowtham, Chang, Grace, Eke, Grace, Lee, Grace, Massarra, Grace, Travaglini, Grazia, Scialandrone, Grazisa, Stavrou, Gregor A., Di Franco, Gregorio, Charalambous, Gregory, Christodoulidis, Gregory, Kouraklis, Gregory, Goodwin, Gregory Richard, Devidze, Grigol, Fialho, Guilherme, Santos, Guilherme, Cabezudo, Guillermo, García-Santos, Guillermo, Pou, Guillermo, Romero Reyna, Guillermo, Yanowsky-Reyes, Guillermo, Ozyuksel, Gul, Karadeniz Cakmak, Guldeniz, Kucuk, Gultekin Ozan, Bulbuloglu, Guney Cem, Sarp, Guray, Kaur, Gurleen, Nibogora, Guy Darcy, Hamdan, Gymar, Ogundipe, Habeeb, Yunes, Habib, Ayesh, Hadeel, Al Atassi, Hadi, Jalilehvand, Hadis, Masalma, Hafez, Jafarkhan, Hafis, Shahid, Hafiz Huzaifa, Younus, Hafsa, Al-Derume, Hail, Shames, Haitam, Mimouni, Haithem Ahmed, Aldare, Hajar, Odah Bashi, Hajar Omar, Abusnina, Hajer, Altounsi, Hajir, Qayum, Hajra, Baysal, Hakan, Bolukbasi, Hakan, Yigitbas, Hakan, Alkhatib, Hala, Afzal, Haleema, Mftah, Halima, Oyinlola, Halimah, Tümer, Haluk, Dolo, Hamadoun, Braham, Hamdi, Ozsahin, Hamdi, Abu-Arish, Hamdoon, Al-Aamri, Hamed, Fadlalmola, Hammad Ali, Abu Obead, Hamza, Al-Fahel, Hamza, Al-Zoubi, Hamza, Asaad, Hamza, Ejaz, Hamza, Jaber, Hamza, Bhatti, Hamza Waqar, Mohammadi Sardoo, Hamzeh, Farhat, Hana, Idheiraj, Hanadi, Zwaraa, Hanady, Al Sohabi, Hanan, Basharat, Hanan, Said, Hanan, Al-Abdallat, Haneen, Foad, Haneen, Daaboul, Hanen, Al Qadhi, Hani, Elhallaq, Hani, Alhusaini, Hanin, Lidbetter, Hannah, Reilly, Hannah, Moya- Ambriz, Hannia Betzabeth, Lederhuber, Hans, Fehrer, Hans-Jörg, Xiao, Haotian, Iswariah, Harish, Kaur, Harmeena, Cheema, Harnoor Kaur, Foda, Haroun, Chauhan, Harpreet, Kaur, Harpreet, Sagar, Harry, Unwin, Harry, Kaur, Harsharan, Panga, Harshavardhan, Gupta, Harshit, Prabhakar, Harshit Kumar, Anand, Harshitha, Pahwa, Harvinder Singh, Abbadi, Hasan, Amoudi, Hasan, Zaini, Hasan Hadi Zaini, Škiljo, Hasan, Miyasika, Hasangi, Altabbaa, Hashem, Haj Freej, Hasn, Abdelazim, Hassan, Habiba, Hassan, Kamal, Hassan, Sabir, Hassan, Zaigham, Hassan, Pehlivan, Hatice, Telci, Hatice, Abuobaida, Hayat, Tetley, Heather, Taher, Heba, Aguado López, Héctor, Askarpour, Hedyeh, Sherif Farouk Ahmed Hassan, Heidi, Devesa, Helena, Arbogast, Helmut, Nuñez Del Barrio, Henar, Abiyere, Henry, Delacave, Henry, Rice, Henry E., Pleass, Henry, Bradly, Hera, 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Rugambwa, Jean Paul, Jordaan, Jean- Jacques, Razafindrahita, Jeannie Ba, Do, Jee Eun, Senavirathna, Jeewantha, Kalyanapu, Jeffrey A, Chan, Jeffrey, Ofori, Jeffrey, Otote, Jeffrey, Akiely, Jehad, Cassiano Neves, Jelena, Gillingham, Jemima, Herrera Batres, Jenifer Olga María, Ezeh, Jennifer, Okei, Jennifer, Vu, Jennifer, Guevara, Jenny, Siu, Jenny, Rolinger, Jens, Skaff, Jeolle, Uys, Jernelle, Makama, Jerry Godfrey, Barklimore, Jessica, Dei-Asamoa, Jessica, Jahjah, Jessica, Jones, Jessica, Ng, Jessica, Ricardo, Jéssica, Schembri Higgans, Jessica, You, Jessica, Annan, Jessie, Aguilar, Jesus Antonio, Pizarro Lozano, Jesús, Lim, Jia Hui, Zhu, Jiang, Wang, Jianxue, Abbasy, Jibran, Ugwu, Jideofor, Rathod, Jignesh, Albalushi, Jihan, Najajra, Jinan, Fu, Jing Hui, Tefay, Joan Sia Tan, Domingues, Joana Cristina, Simoes, Joana FF, Figueiredo, Joana, Fontaínhas, Joana, Frazão, Joana, Marques Antunes, Joana, Simoes, Joana, Marx, Joanna Naemi, Dias-Ferreira, João, Fernandes, João, Mendes, João, Pinho, João, Ribeiro, João, Vaz, João, Dominguez, Joaquina, Abutu John, Job, Chen, Joe Jun Qiao, Enaholo, Joel, Alaji, Joelle, Miller, Johanna, Binder, Johannes, Daleku, John, Katogiritis, John, Khoury, John, Anyorigiya, John Noah, Reilly, John, Abebrese, John Tabiri, Ahale, Johnny Lordson, Tabora-Zepeda, Johnny, Barrutia Leonardo, Jon, Demma, Jonathan Abraham, Hong, Jonathan, Chejfec-Ciociano, Jonathan Matias, Oppong, Jonathan, Quansah, Jonathan, Sutcliffe, Jonathan, Taiwo, Jones, Nyamekye - Baidoo, Joojo, Prat-Ortells, Jordi, Dongmo, Jordy, Kleeff, Jorg, Jimenez Flores, Jorge Alberto, Pellecer Cano, Jorge Bernardo, Chóliz, Jorge, Giubi Bobeda, Jorge Eduardo, Escartin, Jorge, Febré, Jorge, Gass, Jörn-Markus, Calvache, Jose A, Guzman Barba, Jose Aldo, Gutiérrez Gómez, José Alonso, Calvache, Jose Andres, Acevedo Parrales, José Danilo, Orozco Navarro, José Esteban, Viñas, José Federico, Gomez, José, Goncalves-Nobre, Jose Guilherme, Valenzuela, José Ignacio, Garcia Galocha, Jose Luis, 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Marcella, Pisano, Marcello, Doniquian, Marcelo Alejandro, Martínez Bareiro, Marcelo Nicolás, Pagani, Marcelo, Scortechini, Marcelo, Carvalho, Márcia, Sánchez Audelo, Marco Antonio, Brizzolari, Marco, Ceresoli, Marco, De Prizio, Marco, Amisano, Marco Francesco, Gramellini, Marco, Marcianò, Marco, Mariani, Marco, Milone, Marco, Montagna, Marco, Piccino, Marco, Santos, Marco, Dyer, Marcus, Kang, Marcus, Mahadi, Mardhiana, Zawadzki, Marek, Yinusa, Margaret, Bernardo, Margarida, Nunes Luís, Margarida, Gambelli, Margherita, Flint, Margot, Aggelidou, Maria, Bequis, Maria Agustina, Sotiriou, Maria Aikaterini, Ñañez, Maria Alejandra, Tahir, Maria Ambreen, Gascón Domínguez, María Ángeles, Asimakidou, Maria, Mourato, Maria Beatriz, Blanco, Maria, Christou, Maria, Coronas Soucheiron, Maria, Pignanelli, Maria Costanza, Kalaydjian, María Cristina, Martí-Ejarque, Maria del Mar, Olmedo Reinoso, María Del Mar, Cebollero, María Del Pilar, Derattani, Maria, Gama Caldeira, Maria Do Carmo, Drogouti, Maria, Gonzalez-Gonzalez, Maria Elena, Muñoz Fernández, María Elena, Muriel, María Emilia, Duran, María Eugenia, Zarate Casas, María Fernanda, Florou, Maria, Piacentini, Maria Gaia, Seixo, Maria Inês, Bellini, Maria Irene, Peña Soria, Maria Jesús, Martínez, María José, Medina, Maria José, Rueda Medécigo, María José, Karakeke, Maria, Kausar, Maria, Kyriazi, Maria, Marqueta De Salas, Maria, Modolo, Maria Marta, Mateu, Maria, Mavri, Maria, El Ghoul Miliotou, Maria Melina, Moreno Gijon, Maria, Papadoliopoulou, Maria, Proclamà, Maria Pia, Picciochi, Maria, Reis, Maria, Rennis, Maria, D'Anna, Maria Rosa, Ruffoli, Maria, Ruiz Soriano, María, Sánchez Ramirez, Maria, Sánchez-Rubio, María, Schüler, Maria, Sotiropoulou, Maria, Barrio Renteria, Maria Teresa, Tsopozidi, Maria, Vasconcelos, Maria, Facchino, Maria Vittoria, Wikar, Maria, Aguilera-Arevalo, Maria-Lorena, Abdu, Mariam, Asarbakhsh, Mariam, Elmiesiry, Mariam, Ashong, Marian Esi, Gomes, Mariana, Capuano, Marianna, Lill, Marianne, Nieto Galvan, 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Nathan, Michael, Maclean, Michael, Nortey, Michael, Pellen, Michael, Pham, Michael, Pitiakoudis, Michael, Singh, Michael Prodip, Spartalis, Michael, Van Der Colf, Michael, Wilson, Michael, Billis, Michail, Karanikas, Michail, Papamichail, Michail, Vailas, Michail, Kisielewski, Michał, Kusiński, Michał, Nycz, Michał, Święch, Michał, Fagbayimu, Micheal, Adamina, Michel, Fiogbe, Michel, Prudhomme, Michel, Angelucci, Michela, Campanelli, Michela, Cricrì, Michele, Grande, Michele, Manigrasso, Michele, Scopelliti, Michele, George, Michelle, Mozel, Michelle, Galasyuk, Mick, Chevallay, Mickael, Giuliano, Micol, Dobón Rascón, Miguel Ángel, Fernandez Romero, Miguel Angel, García Ureña, Miguel Ángel, Zaragoza Mendieta, Miguel Ángel, Bejarano Serrano, Miguel, Brito, Miguel, Calderon, Miguel, Jurado Román, Miguel, Palas, Miguel, Li Valencia, Miguel Roberto, Sebastián-Mendoza, Miguel-Julián, Muresan, Mihai-Stefan, Slavchev, Mihail, Agapov, Mikhail, Milentijević, Milica, Catterall, Millie, 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Abosedra, Mohammed, Sarker, Mohammed Abu Kawsar, Abudabbous, Mohammed, Abuwarda, Mohammed, Elgak, Mohammed Ahmed, Al Hinai, Mohammed, Al Zebda, Mohammed, Al-Shehari, Mohammed, Alharthi, Mohammed, Ali, Mohammed, Ismael Alamin, Mohammed Ali, Alqadasi, Mohammed, Alshanwani, Mohammed, Alshehri, Mohammed, Asaad, Mohammed, Bashir, Mohammed, Bohlala, Mohammed, Meghaizerou, Mohammed El Amine, Albanna, Mohammed Emad Hashem, Ghunaim, Mohammed, Goga, Mohammed, Hajhamad, Mohammed, Hamada Takrouney, Mohammed, Hammoda, Mohammed, Hamoud Almahly, Mohammed, Muragi, Mohammed, Mohammed, Mohammed Mustafa Hassan, Obaid, Mohammed, Omar, Mohammed, Said, Mohammed, Salah, Mohammed, Saleh Khatab, Mohammed, Aliyu, Mohammed Salele, Shakhshir, Mohammed, Sheriff, Mohammed, Tageldin, Mohammed, Abdelfattah, Mohanad, Daher, Mohanad, Lotfy, Mohanad, Alqedrh, Mohannad, Nasani, Mohannad, Mohd Shah, Mohd Shahrulsalam, Madany, Mohie El-Din Mostafa, Mobolaji-Ojibara, Mojisola, Nkogatse, Moleseng, Alazabi, Mona, Gupta, 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López, Sara, Giovampietro, Sara, Ismail, Sara, Kamari, Sara, Lauricella, Sara, Marzorati, Sara, Mohammed, Sara, Moschella, Sara, Mostafa Yassin, Sara, Patrocínio, Sara, Massa, Sara Tiziana, Vertaldi, Sara, Abdelmohsen, Sarah, Al Sharie, Sarah, Barbosa Castelo Branco, Sarah, Bowman, Sarah, Condron, Sarah, Elfurdag, Sarah, Ellouzy, Sarah, Fennelly, Sarah, Mansour, Sarah, Molfino, Sarah, Qwyder, Sarah, Rennie, Sarah, Robinson, Sarah, Segnitome, Sarah, Staight, Sarah, Yassin, Sarah, Alsibai, Sareyah, Khan, Sarfaraz, Khurana, Sarita, Rafiq, Sarmad, Malhi, Sarvpreet Singh, Dognia, Satchmo, D A, Sathiafrey, Babu, Satia, Subbiah Nagaraj, Satish, Meena, Satya Prakash, Vasquez, Saul, Bradulskis, Saulius, Mikalauskas, Saulius, Laura, Saura García, Verhage, Savannah Skye, Simeonidis, Savvas, Sarwary, Sayed Haschmatullah, Naidu, Sayuri, Schimpke, Scott, Davis, Sean, Stevens, Sean, Sierra, Sebastian, Dos Santos, Sebastiano, Strachan, Sebastien, Bektas, Sebnem, Atupra, Sedinam Adjoa Asiedua, Kreid, 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Sharitha, Laura, Sharon, Shanker, Shashwat, Ababneh, Shatha, Gilbert, Shaun, Kenworthy, Shaunna, Ng, Shawn Hong Ming, Mackenzie, Shawn, Salindera, Shehnarz, Khattak, Shehrbano, Loke, Sheih Nee, Manzoor, Sheikh Viqar, Alwardi, Sheikha, Allam, Shereen, Tawfik, Sherifa, Francis, Shikha, Cai, Shirley, Dindyal, Shiva, Pandya, Shivangi, Chopra, Shreya, Ingley, Shreya, Kulkarni, Shrirang, Kosna, Shuba, Nayak, Shubhalaxmi, Ahuja, Shubham, Hariharan, Shubhang, Karuppusamy Krishnasamy, Shyam, Khare, Siddhant, Handa, Siddhartha, Amin Omar Alsiddig, Siddig, Alqurashi, Siddiga, Al-Tahayneh, Sief-Addeen, Sibiya, Silindokuhle, Perretta, Silvana, Ibarra Camargo, Silvia Alejandra, Montisci, Silvia, Mungo, Silvia, Puddu, Silvia, Severi, Silvia, Agudelo Mendoza, Silvia Valentina, Makkai-Popa, Silviu Tiberiu, Boyes, Simon, Monkhouse, Simon, Stock, simon, Alberti, Simona, Meneghini, Simona, Giudici, Simone, Guadagni, Simone, Birolo, Simone Lorenzo, Novello, Simone, Oliveira, Simone, Gumede, Simphiwe, Dhole, Simran, Budhwani, Simran Saleem, Ramjit, Sinead, Yumurtacilar, Sinem, Mahendra, Sirigi Naga, Abeykoon, Sithira, Moh Pauzi, Siti Farhan, Rajendra, Sittampalam, Sundararajan, Siva, Gananadha, Sivakumar, Kamarajah, Sivesh K, Marawu, Siyasanga, Basu, Sk, Hassan, Sleman, Reddy, Snigdha Mettu, Anaya Sanchez, Sofia, Gaspar Reis, Sofia, Gomez, Sofía, Gamba, Sofia Lucia, Pimentel Morais, Sofia, Ashry, Soha, Abdullateef, Sohaila, Bandyopadhyay, Soham, Samadi, Soheil, Pathan, Sohilkhan R., Lakew, Solomon, Basu, Somprakas, Ohri, Sonali, Alonso Marcos, Sonia, Amoza Pais, Sonia, Fortuna Martins, Sónia, Gill, Sonia, Matthiess, Sonia, Sabbatini, Sonia, Soto Schütte, Sonia, Engel, Sophie, Eam, Sothseyhakmonique, Botaitis, Sotirios, Lawani, Souliath, Jamil, Soumaya, Kondpan, Sourav, Oum, Sovannarith, Govender, Sovishnee, Christodoulou, Spyridon, Davakis, Spyridon, Vernadakis, Spyridon, Gkogkos, Spyros, Gobishangar, Sreekanthan, Suresh, Sreelakshmi, Vembar, Sridhar, M, Srikanth, Abdelrasoul Elnour Ismail, Srraa, Zourntou, Stamatina-Emmanouela, Nwabuoku, Stanley Emeka, Ideh, Stanley, Charitonos, Stavria, Liapis, Stavros Chrysovalantis, Faber, Stefan, Piccioni, Stefania Angela, Romano, Stefania, Silvestre, Stefania, Jarmusch, Stefanie, Soelling, Stefanie, Cardelli, Stefano, Chaifouroosh Mamagany, Stefano, Corso, Stefano, Basso, Stefano Maria Massimiliano, Megna, Stefano, Bitsianis, Stefanos, Tsatsos, Stefanos, Morales, Steffanía, Gerdes, Stephan, Göller, Stephanie, Hanna, Stephanie, Tabiri, Stephen, Agana, Stephen, Theivendran, Stephen Arthur, Kache, Stephen, Knight, Stephen R, Smith, Stephen, Stonelake, Stephen, Wrenn, Stephen, Gopaul, Steven, Vederaki, Styliani, Kapiris, Stylianos, Kykalos, Stylianos, Hlaing, Su Su, Chia, Su Yin Denise, Abu Khousa, Suad, M. Udwan, Suad, Raul, Subrat, Chase, Suchita, Nair, Sudharrshan, Joseph, Sudhir, Singh, Sudhir Kumar, Singh, Sudhir, Timmalah, Suhaylah, Alsuwiyah, Suhir, Thalgaspitiya, Sujeewa Priyantha Bandara, Sellahewa, Sujeewa, Neogi, Sujoy, Burger, Sule, Polat, Süleyman, Alkadi, Sulman, Asiri, Sultan, Otho, Sumaira, Mewa Kinoo, Suman, Ebrahim, Sumayyah, Tontus, Sumeyya, Midya, Sumit, Thuraisamy Sarma, Sundaramoorthy Iyer, Payyanur Thotan, Sundeep, Kumar Venkatappa, Sunil, Techapongsatorn, Suphakarn, Kaur, Supreet, Jp, Supritha, Tan, Suqi, Djote, Surafel Mulatu, Surendran, Suraj, Singh, Surendra, Chilaka, Suresh, Lee, Susan, Henriques, Susana, Giridaran, Suseendirarajah, Achugatla, Sushma, Kumar, Suvam, Brincat, Svetlana, Deshpande, Swati, Batista, Sylvia, Akharaekpanya, Tachporn, Moges, Tadesse Girma, Türkmen, Taha Berkay, Alhaj Hasan, Taima, Alshawabkeh, Taima', Majed, Taima', Lawal, Taiwo Akeem, Ibiyeye, Taiye Taibat, Rashid, Tajamul, Košir Božič, Tajda, Mohammed, Tajudeen, Khewater, Talal, Abelman, Talia, Al Barhi, Tamadher, Mogne, Tamiris, Salazar-Lorenzana, Tania Abril, Akter, Tania, Gómez Sanz, Tania, Motiwala, Tanmay, Valizadeh Elizeh, Tanya, Almahdi, Tanzeel, Albushary, Tanzel Alrahman, Abdulrahman, Taofeeq, Finlay, Tara, Chouari, Tarak, Awad, Tarek, Sabra, Tarek, M. Abubasheer, Tareq, Alhusban, Tariq, Yılmaz, Tarık Emre, Aloqaili, Tasneem, Aldirawi, Tayef, Karahasanoğlu, Tayfun, Gülşen, Taygun, Jemal, Tebarek, Nadeem, Tehmina, Singh, Tejinder Paul, Alinger, Temsula, Longkumer, Temsutoshi, Lo, Terence, Gimenez Maurel, Teresa, Uprak, Tevfik Kıvılcım, Petropoulou, Thalia, Rawther, Thampi, Techapongsatorn, Thawin, Manickam, Thendral, Padioti, Theodora, Kozonis, Theodoros, Sidiropoulos, Theodoros, Tsirlis, Theodoros, Theodosopoulos, Theodosios, Hessou, Thierry Kinnongni, Uiyapat, Thitapon, Agyen, Thomas, Harris, Thomas, Hugh, Thomas J, Jorgensen, Thomas W., Theivendrampillai, Thrshegan, Pham, Thuy Vy, Branco, Tiago, Nagwamutse, Tijjani Nasiru, Tony V, Tina, Devabalan Koil, Titus, Pilia, Tiziana, Abdulmola, Tmador Mahmed Ali, Oyeyemi, Tobiloba, Kebede, Tolera, Ibarra-Hurtado, Tomás Ramón, Reichelt, Tomas, Gach, Tomasz, Stefura, Tomasz, Wojewoda, Tomasz, Soric, Tomislav, Risteski, Toni, Tridip, Tridip Dutta Baruah, Yotsov, Tsanko, Doma Bhutia, Tshering, Girma, Tsion, Kwan, Tsun Yu, Ivanov, Tsvetomir, Iahmo, TT, Ashkar, Tuleen, Mabogoane, Tumi, Olobatoke, Tunde, Sholadoye, Tunde T., Mishra, Tushar Subhadarshan, Parker, Tyla, Ezomike, Uchechukwu, Dilibe, Uchenna, Kumbhar, Uday, Una, Uduak-Abasi, Grossi, Ugo, Ezidiegwu, Ugochukwu, Edith, Ugwuoke, Daspal, Ujjwal, Kalu, Ukoha Agwu, Dietz, Ulrich, Ronellenfitsch, Ulrich, Wirth, Ulrich, Abdullah, Umar, Rivolta, Umberto, Jayarajah, Umesh, Kanyan Kassim, Umu-Hera, Govindan, Unnikrishnan, Fernandes, Urânia, Akram, Usman, Mohammed Bello, Usman, Omara, Usra, Naidoo, Uvarasen, Mahendravarman, Vaishnaivy, Negoita, Valentina Madalina, Mariottini, Valentina, Murzi, Valentina, Zucchini, Valentina, Agbakwuru, Valentine, Armenta Tapia, Valeria Estefania, Gentilino, Valerio, Borgogni, Vanessa, Ng, Vanessa, Wolfschluckner, Vanessa, Silvestri, Vania, Žufić, Vanja, Gunasaegaram, Varman, Kamalathevan, Vasan, Pillay, Vasanthan, Neykov, Vasil, Kalles, Vasileios, Mousafeiris, Vasileios, Papadopoulos, Vasileios, Tsaousis, Vasileios, Tselepidis, Vasileios, Vougas, Vasileios, Georgilaki, Vasiliki, Nikolaou, Vasiliki, Themelidi, Vasiliki, Manchev, Vassil, Ioannou, Veatriki, Jha, Vedant Shekhar, Dragisic, Vedran, Sutharshan, Vengadasalam, Alonso, Veronica, Brocco, Veronica, Ongil Rodríguez, Verónica, Schirinzi, Veronica, Budyakova, Veronika, Naunova, Vesna, Panduro-Correa, Vicky, Ruiz López, Víctor Andrés, Bill, Victor, Dassah, Victor, Gonzabay, Víctor Eduardo, Etwire, Victor, Modekwe, Victor, Serna-Alarcon, Victor, De Donato, Victor Ugo, Duque Mallén, Victoria, Liu, Victoria, Sharma, Vidushi, Kumar, Vijaya, Muralidharan, Vijayaragavan, Kakotkin, Viktor, Enemuo, Vincent, Kudoh, Vincent, Osoka, Vincent, Siepaal, Vincent, Granata, Vincenza, Dinuzzi, Vincenza Paola, Lizzi, Vincenzo, Ricchiuti, Vincenzo, Mosca, Vinicio, Kanna D, Vinoth, Nair, Vipin Venugopal, Ledda, Virginia, Michael, Vishal, Singh, Vishavdeep, Govindasamy, Vishendran, Kollengode, Viswanathan V, Giordano, Vittoria, Morinelli, Vittoria, Lin, Vivian, Cuk, Vladica, Cijan, Vladimir, Çalik, Volkan, Bakshi, Vrushank, Ten, Vyacheslav, Ratheesh, Vysakh, Alsado, Wael, Mayo, Wafik, Yang, Wah, Rehman, Wajeeh Ur, Abbas, Walaa, Al-Khyatt, Waleed, Mabood, Waleed, Santucci, Walter, Yew, Wan Ting, Tahir, Warda, De Silva, Warusha Dhammika Dulantha, Wijenayake, Wasantha, Almadhoun, Waseem J.N., Alhroub, Wasef, Ebrahim, Wesam, Jabłoński, Wiktor, Krawczyk, Wiktor, Bhatti, William, Lai, William Kwan Ho, Petrushnko, Wilson, Afedo, Wisdom, Kasetsermwiriya, Wisit, Serednicki, Wojciech, Wysocki, Wojciech, Zerefa, Wondwossen Amtataw, Vagena, Xanthoula, Tarrado, Xavier, Papazarkadas, Xenofon, Po, Xiang Yuen, Ouadi, Yacine, Myla, Yacob, Haido, Yacoub, Hasan, Yafea, Karataş, Yağmur, Carpio Colmenares, Yahaira, Galvañ Félix, Yaiza, Balogun, Yakub Lekan, Maktabi, Yaman, Nerabani, Yaman, Fulgence, Yamuremye, De Silva, Yannick, Asar, Yara, Samer Morsy, Yara, Ghaleb, Yasameen Saif Saeed Mohammed, Vashishth, Yash, M S, Yashas, Manickchund, Yashoda, Sakaray, Yashwant, Kara, Yasin, Tosun, Yasin, Zwain, Yasir, Farag, Yasmeen, Jedidi, Yasmine, Seada, Yasmine, Aldebasi, Yasser, Ashour, Yasser, Badr, Yassin, Sarpong, Yaw, Alawneh, Yazan, Aung, Yee Lay, Orabi, Yehia, Lam, Yick Ho, Şen, Yigit Kaan, Koyluoglu, Yilmaz Onat, Huang, Yining, Mintz, Yoav, Perez, Yocarli, Chamara, Yohan, Melkamu, Yohannes, Maestre González, Yolanda, Dean, Yomna, Metaferia, Yonas Yilma, Malki, Yosra, Mohamed, Younis, A. Omar, Yousef, Alhammoud, Yousef, Allaoua, Yousef, Tanas, Yousef, El Okazy, Youssef, Kerolous, Youssef, Mohamed, Youssef, Al-Junaidi, Youssuf, Lakdawala, Yousuf, Lu, Yuann, Asano, Yukio, Altinel, Yuksel, Aktimur, Yunus Emre, Fishman, Yuri, Kudryavcev, Yurii, Tandoğan, Yusuf Iskender, Razafimandimby, Yves Michaël, Adofo-Asamoah, Yvonne, Şenol, Zafer, Odeh, Zahra, Benamrouche, Zahra Rayane, Alkhaier, Zahraa, Al-Sheikh Ali, Zaid, Zaher, Zain Aldin, Alnajjar, Zaina, Al-Balushi, Zainab, Alkhuzaie, Zainab, Khraim, Zakaria, Toutounji, Zakaria, Djama, Zakarya, Farraj, Zamil, Shah, Zamir Ahmad, Khan, Zara, Khan, Zarnigar, Abo Alarous, Zayn Alabden, Asaad, Zaynab, Demetrashvili, Zaza, Lorenc, Zbigniew, Brekalo, Zdrinko, Hannouneh, Zein Alabdin, Robertson, Zelda, Bady, Zeyad, Durna, Zeynep, Wong, Zhen Yu, Fozo, Zien Alabdin, Klib, Zienab, Chin, Ziling, Tamou, Zime Farid, Johnson, Zina, Shabello, Ziyad, Orzeszko, Zofia, Aljalabi, Zohal, Al-Azher El-Hamel, Zohour, Karampotaki, Zoi Rafaila, Valera Sanchez, Zoraida, Matkovic, Zoran, Azhar, Zubair, Qureshi, Zubaria, Correa López, Zulema Margarita, Balciscueta, Zutoia, Musilová, Zuzana, Katusic, Zvonimir, Osama, Zyad, and Dauksa, Zygimantas

Published
2024
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43. Liposomal Formulations of Novel BODIPY Dimers as Promising Photosensitizers for Antibacterial and Anticancer Treatment

Author

Weronika Porolnik, Magdalena Ratajczak, Aleksandra Mackowiak, Marek Murias, Malgorzata Kucinska, and Jaroslaw Piskorz

Subjects
anticancer research, bacterial inactivation, BODIPY, dimers, drug delivery, heavy atom effect, Organic chemistry, QD241-441
Abstract

Synthesis, photochemical properties, liposomal encapsulation, and in vitro photodynamic activity studies of novel BODIPY dimer connected at meso-meso positions and its brominated and iodinated analogs were described. UV-Vis measurements indicated that the dimeric structure of obtained BODIPYs did not significantly influence the positions of the absorption maxima. Emission properties and singlet oxygen generation studies revealed a strong heavy atom effect of brominated and iodinated BODIPY dimers, manifested by fluorescence intensity reduction and increased singlet oxygen generation ability compared to analog without halogen atoms. For the in vitro photodynamic activity studies, dimers were incorporated into two different types of liposomes: positively charged DOTAP:POPC and negatively charged POPG:POPC. The photoinactivation studies revealed high activity of brominated and iodinated dimers incorporated into DOTAP:POPC liposomes on both Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli. Anticancer studies on human breast adenocarcinoma MDA-MB-231 and human ovarian carcinoma A2780 cells revealed that DOTAP:POPC liposomes containing brominated and iodinated dimers were active even at low nanomolar concentrations. In addition, they were more active against MDA-MB-231 cells than A2780 cells, which is particularly important since the MDA-MB-231 cell line represents triple-negative breast cancer, which has limited therapeutic options.

Published
2024
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44. From Fiber Layout to the Sensor: Preparation Methods as Key Factors for High-Quality Coupled-Core-Fiber Sensors

Author

F. Lindner, J. Bierlich, M. Alonso-Murias, D. Maldonado-Hurtado, J. A. Flores-Bravo, S. Sales, J. Villatoro, and K. Wondraczek

Subjects
coupled core fiber, doped silica glass, MCVD, REPUSIL, fiber preparation, optical fiber sensors, Chemical technology, TP1-1185
Abstract

During recent years, the optical-fiber-based simultaneous sensing of strain and temperature has attracted increased interest for different applications, e.g., in medicine, architecture, and aerospace. Specialized fiber layouts further enlarge the field of applications at much lower costs and with easier handling. Today, the performance of many sensors fabricated from conventional fibers suffers from cross-sensitivity (temperature and strain) and relatively high interrogation costs. In contrast, customized fiber architectures would make it possible to circumvent such sensor drawbacks. Here, we report on the development of a high-quality coupled-core fiber and its performance for sensors—from the initial fiber layout via elaboration of the preform and fiber up to the sensor evaluation. A compact, high-speed, and cost-effective interrogation unit using such a specialized coupled-core fiber has been designed to monitor reflectivity changes while even being able to distinguish the direction of the force or impact. Several fiber core material techniques and approaches were investigated, which made it possible to obtain a sufficient volume of material for the required fiber core number and a specialized fiber core geometry in terms of core distances and radial refractive index profile, whilst handling the non-symmetrical fiber architectures of such modeled, complex structures and balancing resources and efforts.

Published
2024
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45. Autism Interest Intensity in Early Childhood Associates with Executive Functioning but Not Reward Sensitivity or Anxiety Symptoms

Author

Godfrey, Kate J., Espenhahn, Svenja, Stokoe, Mehak, McMorris, Carly, Murias, Kara, McCrimmon, Adam, Harris, Ashley D., and Bray, Signe

Abstract

Several theories have been proposed to explain the presentation of intense interests in autism, including theories based on altered executive functioning, imbalanced reward sensitivity, and mitigating anxiety. These theories have yet to be examined in early childhood, yet knowledge of how intense interests emerge could provide insight into how best to manage intensity and support the many benefits of personal interests. Parents of 33 autistic and 42 non-autistic comparison children aged 3-6 years completed questionnaires to assess attention shifting and inhibitory control, responsiveness to rewards, and anxiety symptoms. Each behavior domain was examined for associations with parent-reported interest intensity. In autistic and comparison children, attention shifting was associated with interest intensity, where children with more difficulties showed more intense interests. In autistic children only, inhibitory control of attention also associated with interest intensity, where children with greater difficulties showed more intense interests. Reward and anxiety symptoms did not associate with interest intensity in either group, or across the sample. These findings suggest that, in early childhood, the presentation of intense interests is related to executive functioning regardless of diagnostic group. Helping children develop executive functioning skills may therefore be useful to assist with managing interest intensity in early childhood.

Published
2022
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46. ADAMTS13 recovery in acute thrombotic thrombocytopenic purpura after caplacizumab therapy

Author

Abio Calvete, Mariola, Albert, Albert, Alberto López García, Alberto, Alegre, Adrian, Alkorta Eizagirre, Aitziber, Alonso Escobar, María Nieves, Alonso Madrigal, Cristina, Amunarriz, Cristina, Antelo Caamaño, María Luisa, Arbona Castaño, Cristina, Ballester Ruiz, Maria Carmen, Ballina Martín, Belén, Berberana Fernández de Murias, Margarita, Berrueco Moreno, Ruben, Bueno, Jose Luis, Calderón López, María Teresa, Chica Gullón, Esther, Cid Vidal, Joan, Contreras Barbeta, Enric, Cuéllar Pérez-Ávila, Clara, de la Rubia Comos, Javier, Del Orbe Barreto, Rafael Andres, Del Río Garma, Julio, Díaz Valdés, José R., Diaz-Ricart, Maribel, Diez Gallarreta, Zuriñe, Dueñas Hernando, Virginia, Eguia, Blanca, Escoda, Lourdes, Fernández Docampo, Marta, Fernandez Fuertes, Fernando, Fernández Muñoz, Hermogenes, Fernández Sánchez de Mora, Maria Carmen, Fernandez Zarzoso, Miguel, Fidalgo, Teresa, Flores Ballester, Elena, Fonte Feal, Cristina, Galvez, Francisco Javier, Garcia Arroba Peinado, Jose, García Candel, Faustino, Garcia Erce, Jose Antonio, García Gala, José María, Gimeno, JJ, Gómez, Delia, Gómez Seguí, Inés, Gomez Vazquez, Maria Jesus, Gonzalez, Carlos, González Fernández, Fernando Ataulfo, Gonzalez Porras, Jose Ramon, Gonzalez Rodriguez, Victoria Paz, Goterris Viciedo, Rosa, Guerra Domínguez, Luisa, Guillén García, Helga, Hernandez, Adoracion, Hernández Castellet, José Carlos, Hernandez Mohedo, Francisca, Hernandez Vazquez, Laura, Hidalgo Soto, Marta, Hong Tam, Azueg Hang, Kerguelen Fuentes, Ana Lilia, Leal Bento, Marta, Lopes, Raquel, López, Olga, López Chuliá, Francisca, Maria Jose Busto, Maria Jose, Martín Hernández, María Paz, Martinez Estefano, Elvira, Martinez Nieto, Jorge, Martinez Redondo, Consuelo, Martinez Revuelta, Eva, Medina Marrero, Laura, Mingot Castellano, María Eva, Morales Sanz, María Dolores, Moreno, Gemma, Moreno Beltrán, Mª Esperanza, Moreno Chulilla, Jose Antonio, Nistal Gil, Sara, Oliva Hernandez, Ana Yurena, Pascual, Teresa, Pascual Izquierdo, Crisina, Paumard Rodríguez, Elena, Pecos, Patricia, Peña Marcos, Francisco, Pereira Coelho, Daniela Sofia, Pérez Segura, Gloria Maria, Perez-Lopez, Olga, Prieto Pareja, Elena, Ramiro, Laia, Richart López, Luis Alberto, Rodriguez Dominguez, Maria Jesus, Rodriguez Nuñez, Antonio, Ruiz Sainz, María Elena, Saez Serrano, Isabel, Salinas Argente, Ramón, Sanchez, Maria Elena, Sanchez Anton, Piva, Sánchez Fernández, Mª Soledad, Sebastian, Elena, Simona, Gabriela, Solanich Moreno, Xabier, Soledad Casado, Soledad, Tallón, Jose David, Turcu, Violeta, Valledor Méndez, Manuel, Vidan Y Estevez, Julia, Viejo Llorente, Aurora, Bienert, Álvaro, Serrano, Alfons, Llorente, Laura, Campuzano, Verónica, Tallón, Inmaculada, Pons, Verónica, Linares, Mónica, Valles, Ana, Martínez Francés, Antonio, Freiria, Carmen, González Arias, Elena, Araujo, Enmanuel, Marco de Lucas, Fernando, López, Juan Antonio, Uribe Barrientos, Marisol, Calviño, Michael, Gómez Calafat, Montse, Marco Vera, Pascual, Fariña, Sabela, Zalba, Saioa, Monsalvo, Silvia, Escamilla, Virginia, Mingot-Castellano, María-Eva, García-Candel, Faustino, Martínez-Nieto, Jorge, García-Arroba, José, de la Rubia-Comos, Javier, Gómez-Seguí, Inés, Paciello-Coronel, María-Liz, Valcárcel-Ferreiras, David, Jiménez, Moraima, Cid, Joan, Lozano, Miquel, García-Gala, José-María, Angós-Vazquez, Sonia, Vara-Pampliega, Miriam, Guerra-Domínguez, Luisa, Ávila-Idrobo, Laura-Francisca, Oliva-Hernandez, Ana, Zalba-Marcos, Saioa, Tallón-Ruiz, Inmaculada, Ortega-Sánchez, Sandra, Goterris-Viciedo, Rosa, Moreno-Jiménez, Gemma, Domínguez-Acosta, Lourdes, Araiz-Ramírez, María, Hernández-Mateos, Luis, Flores-Ballesteros, Elena, del Río-Garma, Julio, and Pascual-Izquierdo, Cristina

Published
2024
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47. First-Pass Effect in M1-Occlusion Stroke Patients Treated with Combined Stent-Retriever/Large-Bore Distal Aspiration Catheter Thrombectomy

Author

Remollo, S., Werner, M., Blasco, J., López-Rueda, A., San Roman, L., Jimenez-Gomez, E., Bravo Rey, I., Vega, P., Murias, E., Rosati, S., Pérez-García, C., González, E., Manso, X., Aixut, S., Chirife Chaparro, O., Terceño, M., Bashir, S., Pumar, J. M., Ruiz-González, E., Méndez, J. C., Aguilar Tejedor, Y., Zamarro, J., Castaño, M., Daunis-I-Estadella, P., and Puig, J.

Published
2023
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49. Pre-deployment Verification and Predicted Mapping Speed of MUSCAT

Author

Brien, T. L. R., Ade, P. A. R., Barry, P. S., Castillo-Domínguez, E., Ferrusca, D., Gómez-Rivera, V., Hargrave, P., Rebollar, J. L. Hernández, Hornsby, A., Hughes, D. H., Jáuregui-García, J. M., Mauskopf, P., Murias, D., Papageorgiou, A., Pascale, E., Pérez, A., Rowe, S., Smith, M. W. L., Tapia, M., Tucker, C., Velázquez, M., Ventura, S., and Doyle, S.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The Mexico-UK Submillimetre Camera for AsTronomy (MUSCAT) is a 1.1 mm receiver consisting of 1,500 lumped-element kinetic inductance detectors (LEKIDs) for the Large Millimeter Telescope (LMT; Volc\'an Sierra Negra in Puebla, M\'exico). MUSCAT utilises the maximum field of view of the LMT's upgraded 50-metre primary mirror and is the first M\'exico-UK collaboration to deploy a millimetre/sub-mm receiver on the Large Millimeter Telescope. Using a simplistic simulator, we estimate a predicted mapping speed for MUSCAT by combining the measured performance of MUSCAT with the observed sky conditions at the LMT. We compare this to a previously calculated bolometric-model mapping speed and find that our mapping speed is in good agreement when this is scaled by a previously reported empirical factor. Through this simulation we show that signal contamination due to sky fluctuations can be effectively removed through the use of principle component analysis. We also give an overview of the instrument design and explain how this design allows for MUSCAT to be upgraded and act as an on-sky demonstration testbed for novel technologies after the facility-class TolTEC receiver comes online., Comment: Presented at SPIE Astronomical Telescopes + Instrumentation, 2020

Published
2020

50. MUSCAT focal plane verification

Author

Tapia, M., Ade, P. A. R., Barry, P. S., Brien, T. L. R., Castillo-Domínguez, E., Ferrusca, D., Gómez-Rivera, V., Hargrave, P., Rebollar, J. L. Hernández, Hornsby, A., Hughes, D. H., Jáuregui-García, J. M., Mauskopf, P., Murias, D., Papageorgiou, A., Pascale, E., Pérez, A., Rowe, S., Smith, M. W. L., Tucker, C., Velázquez, M., Ventura, S., and Doyle, S.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The Mexico-UK Submillimetre Camera for Astronomy (MUSCAT) is the second-generation large-format continuum camera operating in the 1.1 mm band to be installed on the 50-m diameter Large Millimeter Telescope (LMT) in Mexico. The focal plane of the instrument is made up of 1458 horn coupled lumped-element kinetic inductance detectors (LEKID) divided equally into six channels deposited on three silicon wafers. Here we present the preliminary results of the complete characterisation in the laboratory of the MUSCAT focal plane. Through the instrument's readout system, we perform frequency sweeps of the array to identify the resonance frequencies, and continuous timestream acquisitions to measure and characterise the intrinsic noise and 1/f knee of the detectors. Subsequently, with a re-imaging lens and a black body point source, the beams of every detector are mapped, obtaining a mean FWHM size of $\sim$3.27 mm, close to the expected 3.1 mm. Then, by varying the intensity of a beam filling black body source, we measure the responsivity and noise power spectral density (PSD) for each detector under an optical load of 300 K, obtaining the noise equivalent power (NEP), with which we verify that the majority of the detectors are photon noise limited. Finally, using a Fourier Transform Spectrometer (FTS), we measure the spectral response of the instrument, which indicate a bandwidth of 1.0--1.2 mm centred on 1.1 mm, as expected., Comment: Presented at SPIE Astronomical Telescopes + Instrumentation, 2020

Published
2020

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