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4,045 results on '"A., Crinò"'

1. Biliary drainage in patients with malignant distal biliary obstruction: results of an Italian consensus conference

Author

Marzioni, Marco, Crinò, Stefano Francesco, Lisotti, Andrea, Fuccio, Lorenzo, Vanella, Giuseppe, Amato, Arnaldo, Bertani, Helga, Binda, Cecilia, Coluccio, Chiara, Forti, Edoardo, Fugazza, Alessandro, Ligresti, Dario, Maida, Marcello, Marchegiani, Giovanni, Mauro, Aurelio, Mirante, Vincenzo Giorgio, Ricci, Claudio, Rizzo, Giacomo Emanuele Maria, Scimeca, Daniela, Spadaccini, Marco, Arvanitakis, Marianna, Anderloni, Andrea, Fabbri, Carlo, Tarantino, Ilaria, and Arcidiacono, Paolo Giorgio

Published
2024
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2. Circulating cell-free and extracellular vesicles-derived microRNA as prognostic biomarkers in patients with early-stage NSCLC: results from RESTING study

Author

Petracci, Elisabetta, Pasini, Luigi, Urbini, Milena, Felip, Enriqueta, Stella, Franco, Davoli, Fabio, Salvi, Maurizio, Beau-Faller, Michele, Tebaldi, Michela, Azzali, Irene, Canale, Matteo, Solli, Piergiorgio, Lai, Giulia, Amat, Ramon, Carbonell, Caterina, Falcoz, Pierre-Emmanuel, Martinez-Marti, Alex, Pencreach, Erwan, Delmonte, Angelo, Crinò, Lucio, and Ulivi, Paola

Published
2024
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3. Clinical implications of the family history in patients with lung cancer: a systematic review of the literature and a new cross-sectional/prospective study design (FAHIC: lung)

Author

Citarella, Fabrizio, Takada, Kazuki, Cascetta, Priscilla, Crucitti, Pierfilippo, Petti, Roberta, Vincenzi, Bruno, Tonini, Giuseppe, Venanzi, Francesco M., Bulotta, Alessandra, Oresti, Sara, Greco, Carlo, Ramella, Sara, Crinò, Lucio, Delmonte, Angelo, Ferrara, Roberto, Di Maio, Massimo, Gurrieri, Fiorella, and Cortellini, Alessio

Published
2024
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4. Circulating cell-free and extracellular vesicles-derived microRNA as prognostic biomarkers in patients with early-stage NSCLC: results from RESTING study

Author

Elisabetta Petracci, Luigi Pasini, Milena Urbini, Enriqueta Felip, Franco Stella, Fabio Davoli, Maurizio Salvi, Michele Beau-Faller, Michela Tebaldi, Irene Azzali, Matteo Canale, Piergiorgio Solli, Giulia Lai, Ramon Amat, Caterina Carbonell, Pierre-Emmanuel Falcoz, Alex Martinez-Marti, Erwan Pencreach, Angelo Delmonte, Lucio Crinò, and Paola Ulivi

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Factors to accurately stratify patients with early-stage non-small cell lung cancer (NSCLC) in different prognostic groups are still needed. This study aims to investigate 1) the prognostic potential of circulating cell-free (CF) and extracellular vesicles (EVs)-derived microRNA (miRNAs), and 2) their added value with respect to known prognostic factors (PFs). Methods The RESTING study is a multicentre prospective observational cohort study on resected stage IA-IIIA patients with NSCLC. The primary end-point was disease-free survival (DFS), and the main analyses were carried out separately for CF- and EV-miRNAs. CF- and EV-miRNAs were isolated from plasma, and miRNA-specific libraries were prepared and sequenced. To reach the study aims, three statistical models were specified: one using the miRNA data only (Model 1); one using both miRNAs and known PFs (age, gender, and pathological stage) (Model 2), and one using the PFs alone (Model 3). Five-fold cross-validation (CV) was used to assess the predictive performance of each. Standard Cox regression and elastic net regularized Cox regression were used. Results A total of 222 patients were enrolled. The median follow-up time was 26.3 (95% CI 25.4–27.6) months. From Model 1, three CF-miRNAs and 21 EV-miRNAs were associated with DFS. In Model 2, two CF-miRNAs (miR-29c-3p and miR-877-3p) and five EV-miRNAs (miR-181a-2-3p, miR-182-5p, miR-192-5p, miR-532-3p and miR-589-5p) remained associated with DFS. From pathway enrichment analysis, TGF-beta and NOTCH were the most involved pathways. Conclusion This study identified promising prognostic CF- and EV-miRNAs that could be used as a non-invasive, cost-effective tool to aid clinical decision-making. However, further evaluation of the obtained miRNAs in an external cohort of patients is warranted.

Published
2024
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5. Clinical implications of the family history in patients with lung cancer: a systematic review of the literature and a new cross-sectional/prospective study design (FAHIC: lung)

Author

Fabrizio Citarella, Kazuki Takada, Priscilla Cascetta, Pierfilippo Crucitti, Roberta Petti, Bruno Vincenzi, Giuseppe Tonini, Francesco M. Venanzi, Alessandra Bulotta, Sara Oresti, Carlo Greco, Sara Ramella, Lucio Crinò, Angelo Delmonte, Roberto Ferrara, Massimo Di Maio, Fiorella Gurrieri, and Alessio Cortellini

Subjects
Lung cancer, NSCLC, Family history of cancer, Germline screening, Medicine
Abstract

Abstract Compared to other malignancies, few studies have investigated the role of family history of cancer (FHC) in patients with lung cancer, yielding largely heterogeneous results. We performed a systematic literature review in accordance with PRISMA guidelines, searching the PubMed and Scopus databases from their inception to November 25, 2023, to identify studies reporting on the role of FHC in patients with lung cancer. A total of 53 articles were included, most with a retrospective design and encompassing a variety of geographical areas and ethnicities. Thirty studies (56.6%) assessed patients with non-small cell lung cancer (NSCLC), while 17 studies (32.1%) assessed patients with mixed histologies. Overall, the rates of FHC ranged from 8.3 to 68.9%, and the rates of family history of lung cancer ranged from 2 to 46.8%. Twenty-seven studies investigated FHC as a potential risk factor for lung cancer, with more than half reporting an increased risk for subjects with FHC. Five studies reported on the potential role of FHC in determining clinical outcomes, and twelve studies examined the relationship between FHC and germline mutations. Notably, only one study reported a significantly increased rate of germline mutations, including ATM, BRCA2, and TP53, for patients with a family history of lung cancer compared to those without, but both groups had a low prevalence of mutations (

Published
2024
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6. On K3-fibred LARGE Volume Scenario with de Sitter vacua from anti-D3-branes

Author

AbdusSalam, Shehu, Crinò, Chiara, and Shukla, Pramod

Subjects
High Energy Physics - Theory
Abstract

In the context of type IIB superstring compactifications on K3-fibred (weak) Swiss-cheese Calabi Yau (CY) orientifolds, we consider the realisation of de Sitter vacua obtained through the introduction of an anti-D3-brane at the tip of a highly warped throat of Klebanov-Strassler type. Aiming to have a concrete global realisation, we perform a systematic search for the CY threefolds with $2 < h^{1,1} < 5$ arising from the Kreuzer-Skarke database, which satisfy the minimal requirements of being K3-fibred and suitable for moduli stabilisation within the LARGE Volume Scenario (LVS). In this context, after scanning the set of K3-fibred CY threefolds with a so-called diagonal del-Pezzo divisor needed for LVS, we realise that one of the main challenging requirements for having anti-D3-brane uplifting is to find a suitable orientifold involution which can simultaneously result in a sufficient large $D3$ tadpole charge along with the presence of suitable $O3$-planes. In our detailed analysis (limited to) using the CY threefolds with small $h^{1,1}$, we observe that these topological requirements rule out most of the CY geometries leading to only few possibly suitable candidates for the purpose of anti-D3-brane uplifting. Subsequently, we present a global model using one such explicit K3-fibred CY threefold with $h^{1,1}=4$ in which all the moduli can be consistently stabilised in a de Sitter minimum of the scalar potential., Comment: v2: 40 pages, 1 figure, improved version to appear in JHEP; v1: 37 pages, 1 figure

Published
2022
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7. A Database of Calabi-Yau Orientifolds and the Size of D3-Tadpoles

Author

Crinò, Chiara, Quevedo, Fernando, Schachner, Andreas, and Valandro, Roberto

Subjects
High Energy Physics - Theory
Abstract

The classification of 4D reflexive polytopes by Kreuzer and Skarke allows for a systematic construction of Calabi-Yau hypersurfaces as fine, regular, star triangulations (FRSTs). Until now, the vastness of this geometric landscape remains largely unexplored. In this paper, we construct Calabi-Yau orientifolds from holomorphic reflection involutions of such hypersurfaces with Hodge numbers $h^{1,1}\leq 12$. In particular, we compute orientifold configurations for all favourable FRSTs for $h^{1,1}\leq 7$, while randomly sampling triangulations for each pair of Hodge numbers up to $h^{1,1}=12$. We find explicit string compactifications on these orientifolded Calabi-Yaus for which the D3-charge contribution coming from O$p$-planes grows linearly with the number of complex structure and K\"ahler moduli. We further consider non-local D7-tadpole cancellation through Whitney branes. We argue that this leads to a significant enhancement of the total D3-tadpole as compared to conventional $\mathrm{SO}(8)$ stacks with $(4+4)$ D7-branes on top of O7-planes. In particular, before turning-on worldvolume fluxes, we find that the largest D3-tadpole in this class occurs for Calabi-Yau threefolds with $(h^{1,1}_{+},h^{1,2}_{-})=(11,491)$ with D3-brane charges $|Q_{\text{D3}}|=504$ for the local D7 case and $|Q_{\text{D3}}|=6,664$ for the non-local Whitney branes case, which appears to be large enough to cancel tadpoles and allow fluxes to stabilise all complex structure moduli. Our data is publicly available under http://github.com/AndreasSchachner/CY_Orientifold_database ., Comment: 30 pages plus appendices, 5 figures

Published
2022
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8. The 1st i-EUS consensus on the management of pancreatic fluid collections – Part 2

Author

Aragona, Giovanni, Arcidiacono, Paolo Giorgio, Arvanitaki, Marianna, Badas, Roberta, Barresi, Luca, Berretti, Debora, Bocus, Paolo, Camellini, Lorenzo, Cintorino, Davide, Cugia, Luigi, Dabizzi, Emanuele, De Angelis, Claudio Giovanni, Blanco, Giovanna Del Vecchio, Matteo, Francesco Maria Di, Mitri, Roberto Di, Ercolani, Giorgio, Falconi, Massimo, Fantin, Alberto, Ligresti, Dario, Macchiarelli, Raffaele, Mangiafico, Santi, Mangiavillano, Benedetto, Manno, Mauro, Maruzzelli, Luigi, Marzioni, Marco, Pedicini, Vittorio, Piras, Enrico, Pollino, Valeria, Sethi, Amrita, Siddiqui, Uzma, Togliani, Thomas, Traina, Mario, Tringali, Alberto, Venezia, Giovanna, Zerbi, Alessandro, Capurso, Gabriele, Coluccio, Chiara, Rizzo, Giacomo Emanuele Maria, Crinò, Stefano Francesco, Cucchetti, Alessandro, Facciorusso, Antonio, Hassan, Cesare, Amato, Arnaldo, Auriemma, Francesco, Bertani, Helga, Binda, Cecilia, Cipolletta, Fabio, Forti, Edoardo, Fugazza, Alessandro, Lisotti, Andrea, Maida, Marcello, Sinagra, Emanuele, Sbrancia, Monica, Spadaccini, Marco, Tacelli, Matteo, Vanella, Giuseppe, Anderloni, Andrea, Fabbri, Carlo, and Tarantino, Ilaria

Published
2024
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9. The i-EUS consensus on the management of pancreatic fluid collections – Part 1

Author

Aragona, Giovanni, Arcidiacono, Paolo Giorgio, Arvanitaki, Marianna, Badas, Roberta, Barresi, Luca, Berretti, Debora, Bocus, Paolo, Camellini, Lorenzo, Cintorino, Davide, Cugia, Luigi, Dabizzi, Emanuele, De Angelis, Claudio Giovanni, Blanco, Giovanna Del Vecchio, Matteo, Francesco Maria Di, Mitri, Roberto Di, Ercolani, Giorgio, Falconi, Massimo, Fantin, Alberto, Ligresti, Dario, Macchiarelli, Raffaele, Mangiafico, Santi, Mangiavillano, Benedetto, Manno, Mauro, Maruzzelli, Luigi, Marzioni, Marco, Pedicini, Vittorio, Piras, Enrico, Pollino, Valeria, Sethi, Amrita, Siddiqui, Uzma, Togliani, Thomas, Traina, Mario, Tringali, Alberto, Venezia, Giovanna, Zerbi, Alessandro, Capurso, Gabriele, Rizzo, Giacomo Emanuele Maria, Coluccio, Chiara, Crinò, Stefano Francesco, Cucchetti, Alessandro, Facciorusso, Antonio, Hassan, Cesare, Amato, Arnaldo, Auriemma, Francesco, Bertani, Helga, Binda, Cecilia, Cipolletta, Fabio, Forti, Edoardo, Fugazza, Alessandro, Lisotti, Andrea, Maida, Marcello, Sinagra, Emanuele, Sbrancia, Monica, Spadaccini, Marco, Tacelli, Matteo, Vanella, Giuseppe, Anderloni, Andrea, Fabbri, Carlo, and Tarantino, Ilaria

Published
2024
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11. Local ablation disrupts immune evasion in pancreatic cancer

Author

Musiu, Chiara, Adamo, Annalisa, Caligola, Simone, Agostini, Antonio, Frusteri, Cristina, Lupo, Francesca, Boschi, Federico, Busato, Alice, Poffe, Ornella, Anselmi, Cristina, Vella, Antonio, Wang, Tian, Dusi, Silvia, Piro, Geny, Carbone, Carmine, Tortora, Giampaolo, Marzola, Pasquina, D'Onofrio, Mirko, Crinò, Stefano Francesco, Corbo, Vincenzo, Scarpa, Aldo, Salvia, Roberto, Malleo, Giuseppe, Lionetto, Gabriella, Sartoris, Silvia, Ugel, Stefano, Bassi, Claudio, Bronte, Vincenzo, Paiella, Salvatore, and De Sanctis, Francesco

Published
2025
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14. RNA in cardiovascular disease: A new frontier of personalized medicine

Author

Abdul-Rahman, Toufik, Lizano-Jubert, Ileana, Bliss, Zarah Sophia Blake, Garg, Neil, Meale, Emily, Roy, Poulami, Crino, Salvatore Antonio, Deepak, Bethineedi Lakshmi, Miteu, Goshen David, Wireko, Andrew Awuah, Qadeer, Abdul, Condurat, Alexandra, Tanasa, Andra Diana, Pyrpyris, Nikolaos, Sikora, Kateryna, Horbas, Viktoriia, Sood, Aayushi, Gupta, Rahul, and Lavie, Carl J.

Published
2024
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15. Endocrine features of Prader-Willi syndrome: a narrative review focusing on genotype-phenotype correlation

Author

Simona F. Madeo, Luca Zagaroli, Sara Vandelli, Valeria Calcaterra, Antonino Crinò, Luisa De Sanctis, Maria Felicia Faienza, Danilo Fintini, Laura Guazzarotti, Maria Rosaria Licenziati, Enza Mozzillo, Roberta Pajno, Emanuela Scarano, Maria E. Street, Malgorzata Wasniewska, Sarah Bocchini, Carmen Bucolo, Raffaele Buganza, Mariangela Chiarito, Domenico Corica, Francesca Di Candia, Roberta Francavilla, Nadia Fratangeli, Nicola Improda, Letteria A. Morabito, Chiara Mozzato, Virginia Rossi, Concetta Schiavariello, Giovanni Farello, Lorenzo Iughetti, Vincenzo Salpietro, Alessandro Salvatoni, Mara Giordano, Graziano Grugni, and Maurizio Delvecchio

Subjects
Prader-Willi syndrome (PWS), genotype-phenotype correlation, growth hormone (GH), metabolic syndrome, hypogonadism, bone metabolism, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Prader-Willi syndrome (PWS) is a complex genetic disorder caused by three different types of molecular genetic abnormalities. The most common defect is a deletion on the paternal 15q11-q13 chromosome, which is seen in about 60% of individuals. The next most common abnormality is maternal disomy 15, found in around 35% of cases, and a defect in the imprinting center that controls the activity of certain genes on chromosome 15, seen in 1-3% of cases. Individuals with PWS typically experience issues with the hypothalamic-pituitary axis, leading to excessive hunger (hyperphagia), severe obesity, various endocrine disorders, and intellectual disability. Differences in physical and behavioral characteristics between patients with PWS due to deletion versus those with maternal disomy are discussed in literature. Patients with maternal disomy tend to have more frequent neurodevelopmental problems, such as autistic traits and behavioral issues, and generally have higher IQ levels compared to those with deletion of the critical PWS region. This has led us to review the pertinent literature to investigate the possibility of establishing connections between the genetic abnormalities and the endocrine disorders experienced by PWS patients, in order to develop more targeted diagnostic and treatment protocols. In this review, we will review the current state of clinical studies focusing on endocrine disorders in individuals with PWS patients, with a specific focus on the various genetic causes. We will look at topics such as neonatal anthropometry, thyroid issues, adrenal problems, hypogonadism, bone metabolism abnormalities, metabolic syndrome resulting from severe obesity caused by hyperphagia, deficiencies in the GH/IGF-1 axis, and the corresponding responses to treatment.

Published
2024
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16. Corrigendum: Adherence to European society of gastrointestinal endoscopy quality performance measures for upper and lower gastrointestinal endoscopy: a nationwide survey from the Italian society of digestive endoscopy

Author

Rocco Maurizio Zagari, Leonardo Frazzoni, Lorenzo Fuccio, Helga Bertani, Stefano Francesco Crinò, Andrea Magarotto, Elton Dajti, Andrea Tringali, Paola Da Massa Carrara, Gianpaolo Cengia, Enrico Ciliberto, Rita Conigliaro, Bastianello Germanà, Antonietta Lamazza, Antonio Pisani, Giancarlo Spinzi, Maurizio Capelli, Franco Bazzoli, and Luigi Pasquale

Subjects
endoscopy, quality, performance measure, ESGE, guidelines, Medicine (General), R5-920
Published
2024
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21. Endoscopic Ultrasound-Guided Through-the-Needle Biopsy: A Narrative Review of the Technique and Its Emerging Role in Pancreatic Cyst Diagnosis

Author

Filipe Vilas-Boas, Tiago Ribeiro, Guilherme Macedo, Jahnvi Dhar, Jayanta Samanta, Sokol Sina, Erminia Manfrin, Antonio Facciorusso, Maria Cristina Conti Bellocchi, Nicolò De Pretis, Luca Frulloni, and Stefano Francesco Crinò

Subjects
mucinous cystic neoplasm, EUS-FNA, pancreatic cancer, cystic fluid analysis, intraductal papillary mucinous neoplasm (IPMN), neuroendocrine tumor, Medicine (General), R5-920
Abstract

Pancreatic cystic lesions (PCLs) pose a diagnostic challenge due to their increasing incidence and the limitations of cross-sectional imaging and endoscopic-ultrasound-guided fine-needle aspiration (EUS-FNA). EUS-guided through the needle biopsy (EUS-TTNB) has emerged as a promising tool for improving the accuracy of cyst type determination and neoplastic risk stratification. EUS-TTNB demonstrates superior diagnostic performance over EUS-FNA, providing critical preoperative information that can significantly influence patient management and reduce unnecessary surgeries. However, the procedure has risks, with an overall adverse event rate of approximately 9%. Preventive measures and further prospective studies are essential to optimize its safety and efficacy. This review highlights the potential of EUS-TTNB to enhance the diagnostic and management approaches for patients with PCLs. It examines the current state of EUS-TTNB, including available devices, indications, procedural techniques, specimen handling, diagnostic yield, clinical impact, and associated adverse events.

Published
2024
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23. Reflecting on the YouthMappers Movement

Author

Anderson, Jennings, Blevins, Chad, Cowan, Nuala, Carney-Nedelman, Dara, Clark, Courtney, Crino, Michael, Engstrom, Ryan, Hinton, Richard, Mann, Michael, McCusker, Brent, Nealon, Rory, Solís, Patricia, Zeballos, Marcela, Solís, Patricia, editor, and Zeballos, Marcela, editor

Published
2023
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24. Endoscopic ultrasound-guided drainage of pancreatic collections with dedicated metal stents: A nationwide, multicenter, propensity score-matched comparison

Author

Binda, Cecilia, Petrone, Maria Chiara, Berretti, Debora, Macchiarelli, Raffaele, Lovera, Mauro, Attili, Fabia, D'Errico, Francesca, Brancaccio, Mario Luciano, Redaelli, Alessandro, Tasini, Enrico, Ballarè, Marco, Coppola, Franco, Leone, Nicola, Grassia, Roberto, Fusaroli, Pietro, DeAngelis, Claudio, Cipolletta, Fabio, Manno, Mauro, Badas, Roberta, Pollino, Valeria, Camellini, Lorenzo, Bernardoni, Laura, Conte, Elisabetta, Lisotti, Andrea, Mutignani, Massimiliano, Traina, Mario, Arcidiacono, Paolo Giorgio, Coluccio, Chiara, Facciorusso, Antonio, Forti, Edoardo, De Nucci, Germana, Mitri, Roberto Di, Togliani, Thomas, Cugia, Luigi, Ofosu, Andrew, Anderloni, Andrea, Tarantino, Ilaria, Fabbri, Carlo, and Crinò, Stefano Francesco

Published
2024
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26. Perioperative NALIRIFOX in patients with resectable pancreatic ductal adenocarcinoma: The open-label, multicenter, phase II nITRO trial

Author

Melisi, Davide, Zecchetto, Camilla, Merz, Valeria, Malleo, Giuseppe, Landoni, Luca, Quinzii, Alberto, Casalino, Simona, Fazzini, Federica, Gaule, Marina, Pesoni, Camilla, Casetti, Luca, Esposito, Alessandro, Marchegiani, Giovanni, Piazzola, Cristiana, D’Onofrio, Mirko, de Robertis, Riccardo, Gabbrielli, Armando, Bernardoni, Laura, Crino, Stefano F., Pietrobono, Silvia, Luchini, Claudio, Aliberti, Camillo, Martignoni, Guido, Milleri, Stefano, Butturini, Giovanni, Scarpa, Aldo, Salvia, Roberto, and Bassi, Claudio

Published
2024
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27. A real-world retrospective, observational study of first-line pembrolizumab plus chemotherapy for metastatic non-squamous non-small cell lung cancer with PD-L1 tumor proportion score < 50% (PEMBROREAL)

Author

Alessandro Cafaro, Flavia Foca, Oriana Nanni, Marco Chiumente, Marina Coppola, Paolo Baldo, Sabrina Orzetti, Fiorenza Enrico, Vito Ladisa, Rosa Lerose, Patrizia Nardulli, Piera Maiolino, Federica Gradellini, Anna Rita Gasbarro, Gisella Carrucciu, Riccardo Provasi, Paola Cristina Cappelletto, Alessandra Pasqualini, Stefano Vecchia, Marianna Veraldi, Adele Emanuela De Francesco, Lucio Crinò, Angelo Delmonte, and Carla Masini

Subjects
pembrolizumab, non-small cell lung cancer, real-world data, immunotherapy, observational study, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

IntroductionThe phase III Keynote-189 trial established a first-line treatment combining pembrolizumab with pemetrexed and platinum as a standard treatment for patients with stage IV non-small cell lung cancer (NSCLC) without known EGFR and ALK driver mutations and independent of programmed cell death ligand 1 (PD-L1) expression. However, in Italy, eligibility for the National Health Service payment program is limited to patients with PD-L1

Published
2024
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28. Immunotherapy of mesothelioma: the evolving change of a long-standing therapeutic dream

Author

Luana Calabrò, Giuseppe Bronte, Federica Grosso, Luigi Cerbone, Angelo Delmonte, Fabio Nicolini, Massimiliano Mazza, Anna Maria Di Giacomo, Alessia Covre, Maria Fortunata Lofiego, Lucio Crinò, and Michele Maio

Subjects
pleural mesothelioma, immunotherapy, immune checkpoint inhibitors, adoptive cell therapy, epigenetic drugs, Immunologic diseases. Allergy, RC581-607
Abstract

Pleural mesothelioma (PM) is an aggressive and rare disease, characterized by a very poor prognosis. For almost two decades, the world standard treatment regimen for unresectable PM has consisted of a platinum-based drug plus pemetrexed, leading to an overall survival of approximately 12 months. The dramatic therapeutic scenario of PM has recently changed with the entry into the clinic of immune checkpoint inhibition, which has proven to be an effective approach to improve the survival of PM patients. The aim of the present review is to provide a comprehensive overview of the most promising immunotherapeutic-based strategies currently under investigation for advanced PM.

Published
2024
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29. Corrigendum: Kidney disease in adults with Prader-Willi syndrome: international cohort study and systematic literature review

Author

Denise H. van Abswoude, Karlijn Pellikaan, Naomi Nguyen, Anna G. W. Rosenberg, Kirsten Davidse, Franciska M. E. Hoekstra, Ilse M. Rood, Christine Poitou, Graziano Grugni, Charlotte Høybye, Tania P. Markovic, Assumpta Caixàs, Antonino Crinò, Sjoerd A. A. van den Berg, Aart J. van der Lely, and Laura C. G. de Graaff

Subjects
Prader-Willi Syndrome, kidney function tests, proteinuria, urine tract infections, cardiovascular disease, kidney disease, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Published
2024
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31. On de Sitter String Vacua from Anti-D3-Branes in the Large Volume Scenario

Author

Crinò, Chiara, Quevedo, Fernando, and Valandro, Roberto

Subjects
High Energy Physics - Theory
Abstract

We consider de Sitter vacua realised in concrete type IIB Calabi-Yau compactifications with an anti D3-brane at the tip of a warped throat of Klebanov-Strassler type. The K\"ahler moduli are stabilised together with the complex structure modulus of the warped throat. The volume is exponentially large as in the large volume scenario (LVS). We analyse the conditions on the parameters of the EFT such that they are in the region of validity of our approximations, there are no runaway problems and the vacua satisfy all consistency constraints, such as tadpole cancellation. We illustrate our results with an explicit Calabi-Yau orientifold with two K\"ahler moduli and one antibrane on top of an O3-plane in a warped throat, that has the goldstino as its only massless state. The moduli are stabilised with $g_s\sim 0.2$ and volume $\mathcal{V}\sim 10^4$ in string units, justifying the approximation used to derive the corresponding EFT. Although the model lacks chiral matter, it is presented as a proof of concept, chosen to be the simplest realisation of antibrane uplift., Comment: 32 pages, 2 figures

Published
2020
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33. The Italian registry for patients with Prader–Willi syndrome

Author

Salvatore, Marco, Torreri, Paola, Grugni, Graziano, Rocchetti, Adele, Maghnie, Mohamad, Patti, Giuseppa, Crinò, Antonino, Elia, Maurizio, Greco, Donatella, Romano, Corrado, Franzese, Adriana, Mozzillo, Enza, Colao, Annamaria, Pugliese, Gabriella, Pagotto, Uberto, Lo Preiato, Valentina, Scarano, Emanuela, Schiavariello, Concetta, Tornese, Gianluca, Fintini, Danilo, Bocchini, Sarah, Osimani, Sara, De Sanctis, Luisa, Sacco, Michele, Rutigliano, Irene, Delvecchio, Maurizio, Faienza, Maria Felicia, Wasniewska, Malgorzata, Corica, Domenico, Stagi, Stefano, Guazzarotti, Laura, Maffei, Pietro, Dassie, Francesca, and Taruscio, Domenica

Published
2023
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34. The treatment of obesity in children and adolescents: consensus position statement of the Italian society of pediatric endocrinology and diabetology, Italian Society of Pediatrics and Italian Society of Pediatric Surgery

Author

Claudio Maffeis, Francesca Olivieri, Giuliana Valerio, Elvira Verduci, Maria Rosaria Licenziati, Valeria Calcaterra, Gloria Pelizzo, Mariacarolina Salerno, Annamaria Staiano, Sergio Bernasconi, Raffaele Buganza, Antonino Crinò, Nicola Corciulo, Domenico Corica, Francesca Destro, Procolo Di Bonito, Mario Di Pietro, Anna Di Sessa, Luisa deSanctis, Maria Felicia Faienza, Grazia Filannino, Danilo Fintini, Elena Fornari, Roberto Franceschi, Francesca Franco, Adriana Franzese, Lia Franca Giusti, Graziano Grugni, Dario Iafusco, Lorenzo Iughetti, Riccardo Lera, Raffaele Limauro, Alice Maguolo, Valentina Mancioppi, Melania Manco, Emanuele Miraglia Del Giudice, Anita Morandi, Beatrice Moro, Enza Mozzillo, Ivana Rabbone, Paola Peverelli, Barbara Predieri, Salvo Purromuto, Stefano Stagi, Maria Elisabeth Street, Rita Tanas, Gianluca Tornese, Giuseppina Rosaria Umano, and Malgorzata Wasniewska

Subjects
Children, Adolescents, Obesity, Treatment, Nutrition, Physical activity, Pediatrics, RJ1-570
Abstract

Abstract This Position Statement updates the different components of the therapy of obesity (lifestyle intervention, drugs, and surgery) in children and adolescents, previously reported in the consensus position statement on pediatric obesity of the Italian Society of Pediatric Endocrinology and Diabetology and the Italian Society of Pediatrics. Lifestyle intervention is the first step of treatment. In children older than 12 years, pharmacotherapy is the second step, and bariatric surgery is the third one, in selected cases. Novelties are available in the field of the medical treatment of obesity. In particular, new drugs demonstrated their efficacy and safety and have been approved in adolescents. Moreover, several randomized control trials with other drugs are in process and it is likely that some of them will become available in the future. The increase of the portfolio of treatment options for obesity in children and adolescents is promising for a more effective treatment of this disorder.

Published
2023
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35. EUS-guided fine needle biopsy is able to provide diagnosis in rare osteoclast-like giant cells undifferentiated carcinoma of the pancreas: report of two cases

Author

Pop Ruxandra Mihaela, Diaconu Claudia Irina, Rimbaş Mihai, Mateescu Radu Bogdan, Rouhani Farid, Popp Cristiana, Manfrin Erminia, Crinò Stefano Francesco, and Cauni Victor

Subjects
endoscopic ultrasound-guided fine needle aspiration, endoscopic ultrasound-guided fine needle biopsy, immunohistochemistry, osteoclast-like giant cell, pancreatic cancer, tumor markers, Internal medicine, RC31-1245
Abstract

Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells (UC-OGC) is a rare subtype of pancreatic cancer, accounting for less than 1% of all pancreatic tumors. Preoperative diagnosis is cumbersome as cross-sectional imaging is often not capable to distinguish between UC-OGC and other pancreatic tumors such as pancreatic adenocarcinoma, mucinous carcinoma or neuroendocrine tumors and specific tumor markers seem to be lacking. Endoscopic ultrasound r `m(EUS) with tissue acquisition via fine-needle aspiration (FNA) or biopsy (FNB) with microscopic HE staining and immunohistochemistry allows for an accurate diagnosis, thus influencing further treatment. We present herein the cases of two patients with osteoclast-like giant cells tumors of the pancreas diagnosed by EUS-guided fine needle biopsy and perform a literature review on the role of EUS-guided biopsy for diagnosis.

Published
2023
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36. Imaging of hepatocellular carcinoma recurrence after liver transplantation

Author

Giuseppe Mamone, Settimo Caruso, Mariapina Milazzo, Giorgia Porrello, Ambra Di Piazza, Giovanni Gentile, Vincenzo Carollo, Francesca Crinò, Gianluca Marrone, Gianvincenzo Sparacia, Luigi Maruzzelli, Roberto Miraglia, and Salvatore Gruttadauria

Subjects
Recurrence, Hepatocellular carcinoma, Liver transplantation, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Abstract Liver transplantation (LT) provides the highest survival benefit to patients with unresectable hepatocellular carcinoma (HCC). The Milan criteria have been developed for the selection of LT candidates with the goal of improving survival and maintaining an acceptable risk of HCC recurrence. Despite this, recurrence of HCC after LT occurs in up to 20% of cases and represents a major concern due to the poor prognosis of these patients. Furthermore, several extended criteria for the selection of LT candidates have been proposed to account for the growing demand for organs and the resultant increase in the risk of HCC recurrence. Radiologists should be aware that HCC can recur after LT with multiple organ involvement. Knowledge of the location and radiologic appearance of recurrent HCC is necessary to ensure the choice of the most appropriate therapy. This paper aims to comprehensively summarize the spectrum of HCC recurrence after LT and to examine and discuss the imaging features of these lesions. Graphical Abstract Critical relevance statement This paper aims to share a review of imaging findings of HCC recurrence after LT and to make radiologists familiar with the spectrum of this disease.

Published
2023
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39. Endoscopic Ultrasound-guided Radiofrequency Ablation Versus Surgical Resection for Treatment of Pancreatic Insulinoma

Author

Alfieri, Sergio, Arcidiacono, Paolo Giorgio, Arvanitakis, Marianna, Battistella, Anna, Bernadroni, Laura, Brink, Lene, Cintolo, Marcello, Conti Bellocchi, Maria Cristina, Davì, Maria Vittoria, Deguelte, Sophie, Deprez, Pierre, Deviere, Jaques, Ewald, Jacques, Fabbri, Carlo, Ferrari, Giovanni, Furnica, Raluca Maria, Gabbrielli, Armando, Garcés-Duran, Rodrigo, Giovannini, Marc, Gonda, Tamas, Gornals, Joan B., Marx, Mariola, Mazzola, Michele, Mutignani, Massimiliano, Ofosu, Andrew, Pereira, Stephan P., Perrier, Marine, Przybylkowski, Adam, Repici, Alessandro, Sundaram, Sridhar, Tripodi, Giulia, Crinò, Stefano Francesco, Napoleon, Bertrand, Facciorusso, Antonio, Lakhtakia, Sundeep, Borbath, Ivan, Caillol, Fabrice, Do-Cong Pham, Khanh, Rizzatti, Gianenrico, Forti, Edoardo, Palazzo, Laurent, Belle, Arthur, Vilmann, Peter, van Laethem, Jean-Luc, Mohamadnejad, Mehdi, Godat, Sebastien, Hindryckx, Pieter, Benson, Ariel, Tacelli, Matteo, De Nucci, Germana, Binda, Cecilia, Kovacevic, Bojan, Jacob, Harold, Partelli, Stefano, Falconi, Massimo, Salvia, Roberto, Landoni, Luca, and Larghi, Alberto

Published
2023
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40. The Role of Endoscopic Ultrasound and Ancillary Techniques in the Diagnosis of Autoimmune Pancreatitis: A Comprehensive Review

Author

Flavio Metelli, Guido Manfredi, Nico Pagano, Elisabetta Buscarini, Stefano Francesco Crinò, and Elia Armellini

Subjects
autoimmune pancreatitis, endoscopic ultrasound, contrast-enhanced endoscopic ultrasound, time–intensity curves, elastography, fine-needle aspiration, Medicine (General), R5-920
Abstract

Autoimmune pancreatitis (AIP) is a unique form of chronic pancreatitis with a multifactorial pathogenesis. Historically, it has been classified as type 1 and type 2, according to its clinical and histological features. The diagnosis of AIP is challenging and relies on a combination of clinical, histopathologic, serologic, and imaging characteristics. In the available guidelines, the imaging hallmarks of AIP are based on cross-sectional imaging and cholangiopancreatography retrograde endoscopic findings. Endoscopic ultrasound (EUS) is generally used for pancreatic tissue acquisition to rule out pancreatic cancer and diagnose AIP with limited accuracy. Several papers reported the reliability of EUS for providing informative morphologic features of AIP. Nowadays, the improvement in the resolution of EUS conventional images and the development of new ancillary technologies have further increased the diagnostic yield of EUS: contrast-enhanced EUS and EUS elastography are non-invasive and real-time techniques that strongly support the diagnosis and management of pancreatic diseases. In this review article, we will present the role of conventional EUS and ancillary diagnostic techniques in the diagnosis of AIP to support clinicians and endosonographers in managing this condition.

Published
2024
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41. Diagnostic Yield of Endoscopic Ultrasound-Guided Liver Biopsy in Comparison to Percutaneous Liver Biopsy: A Meta-Analysis of Randomized Controlled Trials and Trial Sequential Analysis

Author

Megha Bhandari, Jayanta Samanta, Marco Spadaccini, Alessandro Fugazza, Stefano Francesco Crinò, Paraskevas Gkolfakis, Konstantinos Triantafyllou, Jahnvi Dhar, Marcello Maida, Nicola Pugliese, Cesare Hassan, Alessandro Repici, Alessio Aghemo, Gaetano Serviddio, and Antonio Facciorusso

Subjects
EUS, FNB, FNA, adequacy, tissue, cirrhosis, Medicine (General), R5-920
Abstract

Background: The efficacy of endoscopic ultrasound-guided liver biopsy (EUS-LB) compared to percutaneous liver biopsy (PC-LB) remains uncertain. Methods: Our data consist of randomized controlled trials (RCTs) comparing EUS-LB to PC-LB, found through a literature search via PubMed/Medline and Embase. The primary outcome was sample adequacy, whereas secondary outcomes were longest and total lengths of tissue specimens, diagnostic accuracy, and number of complete portal tracts (CPTs). Results: Sample adequacy did not significantly differ between EUS-LB and PC-LB (risk ratio [RR] 1.18; 95% confidence interval [CI] 0.58–2.38; p = 0.65), with very low evidence quality and inadequate sample size as per trial sequential analysis (TSA). The two techniques were equivalent with respect to diagnostic accuracy (RR: 1; CI: 0.95–1.05; p = 0.88), mean number of complete portal tracts (mean difference: 2.29, −4.08 to 8.66; p = 0.48), and total specimen length (mean difference: −0.51, −20.92 to 19.9; p = 0.96). The mean maximum specimen length was significantly longer in the PC-LB group (mean difference: −3.11, −5.51 to −0.71; p = 0.01), and TSA showed that the required information size was reached. Conclusion: EUS-LB and PC-LB are comparable in terms of diagnostic performance although PC-LB provides longer non-fragmented specimens.

Published
2024
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42. Gastrointestinal bleeding in patients with hereditary hemorrhagic telangiectasia: Long-term results of endoscopic treatment

Author

Guido Manfredi, Stefano Francesco Crinò, Saverio Alicante, Samanta Romeo, Roberto Berté, Silvia Gandolfi, Angelo Spinazzola, Michela Fiini, Pierangelo Forner, and Elisabetta Buscarini

Subjects
RFA and ablative methods, Small intestinal bleeding, Small bowel endoscopy, Diseases of the digestive system. Gastroenterology, RC799-869
Published
2023
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43. Study protocol for a multicenter randomized controlled trial to compare radiofrequency ablation with surgical resection for treatment of pancreatic insulinoma

Author

Crinò, Stefano Francesco, Partelli, Stefano, Napoleon, Bertrand, Conti Bellocchi, Maria Cristina, Facciorusso, Antonio, Salvia, Roberto, Forti, Edoardo, Cintolo, Marcello, Mazzola, Michele, Ferrari, Giovanni, Carrara, Silvia, Repici, Alessandro, Zerbi, Alessandro, Lania, Andrea, Tacelli, Matteo, Arcidiacono, Paolo Giorgio, Falconi, Massimo, Larghi, Alberto, Rizzatti, Gianenrico, Alfieri, Sergio, Panzuto, Francesco, Hindryckx, Pieter, Berrevoet, Frederik, Lapauw, Bruno, Lakhtakia, Sundeep, Sundaram, Sridhar, Samanta, Jayanta, Rastogi, Ashu, and Landoni, Luca

Published
2023
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46. On K3-fibred LARGE Volume Scenario with de Sitter vacua from anti-D3-branes

Author

Shehu AbdusSalam, Chiara Crinò, and Pramod Shukla

Subjects
Flux Compactifications, String and Brane Phenomenology, Superstring Vacua, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract In the context of type IIB superstring compactifications on K3-fibred (weak) Swiss-cheese Calabi Yau (CY) orientifolds, we consider the realisation of de Sitter vacua obtained through the introduction of an D 3 ¯ $$ \overline{D3} $$ -brane at the tip of a highly warped throat of Klebanov-Strassler type. Aiming to have a concrete global realisation, we perform a systematic search for the CY threefolds with 2 < h 1,1 < 5 arising from the Kreuzer-Skarke database, which satisfy the minimal requirements of being K3-fibred and suitable for moduli stabilisation within the LARGE Volume Scenario (LVS). In this context, after scanning the set of K3-fibred CY threefolds with a so-called diagonal del-Pezzo divisor needed for LVS, we realise that one of the main challenging requirements for having D 3 ¯ $$ \overline{D3} $$ -brane uplifting is to find a suitable orientifold involution which can simultaneously result in a sufficient large D3 tadpole charge along with the presence of suitable O3-planes. In our detailed analysis (limited to) using the CY threefolds with small h 1,1, we observe that these topological requirements rule out most of the CY geometries leading to only few possibly suitable candidates for the purpose of D 3 ¯ $$ \overline{D3} $$ -brane uplifting. Subsequently, we present a global model using one such explicit K3-fibred CY threefold with h 1,1 = 4 in which all the moduli can be consistently stabilised in a de Sitter minimum of the scalar potential.

Published
2023
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47. The Italian registry for patients with Prader–Willi syndrome

Author

Marco Salvatore, Paola Torreri, Graziano Grugni, Adele Rocchetti, Mohamad Maghnie, Giuseppa Patti, Antonino Crinò, Maurizio Elia, Donatella Greco, Corrado Romano, Adriana Franzese, Enza Mozzillo, Annamaria Colao, Gabriella Pugliese, Uberto Pagotto, Valentina Lo Preiato, Emanuela Scarano, Concetta Schiavariello, Gianluca Tornese, Danilo Fintini, Sarah Bocchini, Sara Osimani, Luisa De Sanctis, Michele Sacco, Irene Rutigliano, Maurizio Delvecchio, Maria Felicia Faienza, Malgorzata Wasniewska, Domenico Corica, Stefano Stagi, Laura Guazzarotti, Pietro Maffei, Francesca Dassie, and Domenica Taruscio

Subjects
Prader–Willi syndrome, Registry, Genetic diseases, Rare diseases, Quality, Medicine
Abstract

Abstract Background Prader–Willi syndrome (PWS) is a rare and complex genetic disease, with numerous implications on metabolic, endocrine, neuropsychomotor systems, and with behavioural and intellectual disorders. Rare disease patient registries are important scientific tools (1) to collect clinical and epidemiologic data, (2) to assess the clinical management including the diagnostic delay, (3) to improve patients’ care and (4) to foster research to identify new therapeutic solutions. The European Union has recommended the implementation and use of registries and databases. The main aims of this paper are to describe the process of setting up the Italian PWS register, and to illustrate our preliminary results. Materials and methods The Italian PWS registry was established in 2019 with the aims (1) to describe the natural history of the disease, (2) to determine clinical effectiveness of health care services, (3) to measure and monitor quality of care of patients. Information from six different variables are included and collected into this registry: demographics, diagnosis and genetics, patient status, therapy, quality of life and mortality. Results A total of 165 patients (50.3% female vs 49.7% male) were included into Italian PWS registry in 2019–2020 period. Average age at genetic diagnosis was 4.6 years; 45.4% of patients was less than 17 years old aged, while the 54.6% was in adult age (> 18 years old). Sixty-one percent of subjects had interstitial deletion of the proximal long arm of paternal chromosome 15, while 36.4% had uniparental maternal disomy for chromosome 15. Three patients presented an imprinting centre defect and one had a de novo translocation involving chromosome 15. A positive methylation test was demonstrated in the remaining 11 individuals but the underlying genetic defect was not identified. Compulsive food-seeking and hyperphagia was present in 63.6% of patients (prevalently in adults); 54.5% of patients developed morbid obesity. Altered glucose metabolism was present in 33.3% of patients. Central hypothyroidism was reported in 20% of patients; 94.7% of children and adolescents and 13.3% of adult patients is undergoing GH treatment. Conclusions The analyses of these six variables allowed to highlight important clinical aspects and natural history of PWS useful to inform future actions to be taken by national health care services and health professionals.

Published
2023
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48. Endoscopic ultrasound fine-needle biopsy to assess DAXX/ATRX expression and alternative lengthening of telomeres status in non-functional pancreatic neuroendocrine tumors

Author

Mastrosimini, Maria Gaia, Manfrin, Erminia, Remo, Andrea, De Bellis, Mario, Parisi, Alice, Pedron, Serena, Luchini, Claudio, Brunelli, Matteo, Ammendola, Serena, Bernardoni, Laura, Conti Bellocchi, Maria Cristina, Gabbrielli, Armando, Facciorusso, Antonio, Pea, Antonio, Landoni, Luca, Scarpa, Aldo, and Crinò, Stefano Francesco

Published
2023
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49. Regret affects the choice between neoadjuvant therapy and upfront surgery for potentially resectable pancreatic cancer

Author

Alfieri, Sergio, Amato, Arnaldo, Amisano, Marco, Anderloni, Andrea, Maestri, Antonio, Coluccio, Chiara, Brandi, Giovanni, Casadei-Gardini, Andrea, Cennamo, Vincenzo, Crinò, Stefano Francesco, Valle, Raffaele Dalla, De Angelis, Claudio, Di Battista, Monica, Di Maio, Massimo, Di Marco, Mariacristina, Di Marco, Marco, Di Matteo, Francesco, Di Mitri, Roberto, Ettorre, Giuseppe Maria, Facciorusso, Antonio, Farina, Gabriella, Ferrari, Giovanni, Fornaro, Lorenzo, Frigerio, Isabella, Frisone, Daniele, Fuccio, Lorenzo, Gardini, Andrea, Garufi, Carlo, Giampieri, Riccardo, Grazi, Gian Luca, Jovine, Elio, Kauffmann, Emanuele, Langella, Serena, Larghi, Alberto, Manno, Mauro, Marciano, Emanuele, Marzioni, Marco, Merighi, Alberto, Mutignani, Massimiliano, Nardo, Bruno, Niger, Monica, Palmisano, Valentina, Partelli, Stefano, Pinto, Carmine, Piras, Enrico, Rapposelli, Ilario Giovanni, Reni, Michele, Ricci, Claudio, Rimassa, Lorenza, Siena, Salvatore, Spada, Cristiano, Sperti, Elisa, Spezzaferro, Mariangela, Sposito, Carlo, Tamberi, Stefano, Troisi, Roberto, Veneroni, Luigi, Vivarelli, Marco, Zerbi, Alessandro, Cucchetti, Alessandro, Djulbegovic, Benjamin, Crippa, Stefano, Hozo, Iztok, Sbrancia, Monica, Tsalatsanis, Athanasios, Binda, Cecilia, Fabbri, Carlo, Salvia, Roberto, Falconi, Massimo, and Ercolani, Giorgio

Published
2023
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50. EUS-guided gastroenterostomy using a novel electrocautery lumen apposing metal stent for treatment of gastric outlet obstruction (with video)

Author

Mangiavillano, Benedetto, Larghi, Alberto, Vargas-Madrigal, Jorge, Facciorusso, Antonio, Di Matteo, Francesco, Crinò, Stefano Francesco, Pham, Khanh Do-Cong, Moon, Jong Hoo, Auriemma, Francesco, Camellini, Lorenzo, Paduano, Danilo, Stigliano, Serena, Calabrese, Federica, Ofosu, Andrew, Al-Lehibi, Abed, and Repici, Alessandro

Published
2023
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