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1,567 results on '"A., HIROTSUNE"'

1. Important Notes for Preventing Entrapment of Distal Filter-based Embolic Protection Device in Carotid Artery Stenting

Author

Juntaro FUJITA, Nobuyuki HIROTSUNE, Yuki MATSUDA, Osamu HAMASAKI, Shoichi FUKUDA, Yoshihiro OKADA, Aiko KOBASHI, Shohei NISHIGAKI, Keigo MAKINO, Yusuke TOMITA, Naoya KIDANI, Kenichiro MURAOKA, and Shigeki NISHINO

Subjects
carotid artery stenting, distal filter-based embolic protection device, complication, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Failure to retrieve a distal filter-based embolic protection device (EPD) is a potential complication of carotid artery stenting. This may be caused by trapping of the proximal marker of the EPD within the stent tip marker. Maintaining an adequate distance between the two can prevent this. We examined the behavior of several stent-filter-based EPD combinations, focusing on their propensity to become trapped or disengage in vitro. Four physicians subjectively rated the force required to result in trapping using a 5-point scale. Moreover, the force required to disengage trapped devices was evaluated. The Casper stent-Spider FX EPD combination was difficult to disengage when entrapment occurred, which suggested that this phenomenon tended to occur with this combination. The stent tip marker of the closed-cell stents advanced as they shortened, which may be a unique feature of closed-cell stents. Although trapping is uncommon, it can cause serious complications. To prevent these complications, device characteristics should be well understood before they are used in patients.

Published
2024
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2. Making Neuroendovascular Therapy for Cerebrovascular Disease Using Distal/Trans-radial Artery Access Safer

Author

Okuma, Yu, Hirotsune, Nobuyuki, Hirahata, Shinobu, Tanda, Akane, Suzuki, Kazumoto, Shimoda, Kentaro, Kido, Goro, Kagawa, Yukihide, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, Rosenhouse-Dantsker, Avia, Series Editor, Gerlai, Robert, Series Editor, Sakatani, Kaoru, editor, Masamoto, Kazuto, editor, Yamada, Yukio, editor, Scholkmann, Felix, editor, and LaManna, Joseph C., editor

Published
2024
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4. Detection of influenza A(H3N2) viruses with polymerase acidic subunit substitutions after and prior to baloxavir marboxil treatment during the 2022–2023 influenza season in Japan

Author

Chon, Irina, Wagatsuma, Keita, Saito, Reiko, Tang, Julian W., Isamu, Sato, Suzuki, Eitaro, Shirahige, Yutaka, Kawashima, Takashi, Minato, Michiyoshi, Kodo, Naoki, Masaki, Hironori, Hamabata, Hirotsune, Yoshioka, Sayaka, Ichikawa, Yusuke, Sun, Yuyang, Li, Jiaming, Otoguto, Teruhime, and Watanabe, Hisami

Published
2024
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5. Effect of the Factor XIa Inhibitor Asundexian According to Baseline Infarct Pattern and on MRI Covert Infarct Outcomes

Author

Smith, Eric E., Shoamanesh, Ashkan, Xu, Lizhen, Heenan, Laura, Saad, Feryal, Colorado, Pablo, Chen, Chih-Hao, Lemmens, Robin, De Marchis, Gian Marco, Caso, Valeria, Masjuan, Jaime, Hirano, Teruyuki, Milanov, Ivan, Campbell, Bruce C.V., Mas, Jean-Louis, Connolly, Stuart J., Mundl, Hardi, Hart, Robert G., Bailey, P., Kleinig, T., Cordato, D., Choi, P., Garcia-Esperon, C., Chew, A., Cloud, G., Stanislaus, V., Krause, M., Priglinger, M., Grimley, R., Ghia, D., Sahathevan, R., Brown, H., Kwan, C., Devlin, M., Greisenegger, S., Bonelli-Nauer, S., Rath, J., Langer, A., Marko, M., Ferrari, J., Bernegger, A., Baumgartinger, M., Vigl, M., Krebs, S., Lang, W., Knoflach, M., Dejakum, B., Kiechl, S., Töll, T., Domig, L., Mutzenbach, J.S., Ganser, B., Hecker, C., Rösler, C., Bubel, N., Pikija, S., Zellner, T., Leitner, U., Berger, O., Surböck, B., Beirer, S., Staykov, D., Schrammel, D., Halilovic, A., Frattner, M., Barmherzigen, D., Lampl, C., Höfer, C., Nagl, S., Bocksrucker, C., Demeestere, J., Desfontaines, P., Ciobanu, C., De Pauw, A., Terwecoren, A., Hasenbroekx, M.C., Clement, F., De Klippel, N., Soors, P., Hermans, S., De Raedt, S., Vandervorst, F., Seynaeve, L., Fockaert, N., Smet, S., Rutgers, M., Del Gaudio, N., Paindeville, P., Staikov, I., Simeonova, A., Stoyanova, I., Cholakova, M., Mihnev, N., Petrova, T., Koralova, A., Dimov, D., Kuzev, Y., Danovska, M., Marinova, D., Marinova-Trifonova, D., Ovcharova, E., Mladenovski, I., Yanakieva, M., Stoev, P., Dimitrova, M., Todorova-Georgieva, S., Haralanov, L., Milkov, B., Solakov, D., Petkova, N., Ignatova-Valkova, V., Karabinov, V., Marinova, V., Miteva, Y., Andonova, V., Kasabova, D., Kostadinova, E., Shopova-Vrabcheva, Y., Gatev, D., Semova, D., Halil, E., Kaprelyan, A., Ivanov, B., Panov, G., Grudkova, M., Syuleyman, N., Kalpachki, R., Alexiev, F., Ivanova, I., Kancheva, K., Sakelarova, T., Maslarov, D., Drenska, D., Georgiev, V., Petrova, K., Petrova, N., Ivanova, I., Semerdjieva, N., Zhelyazkov, P., Spasova-Markova, S., Dong, X., Wang, D., Wang, S., Huang, W., Zhao, H., Wang, C., Jie, L., Xinyang, Y., Ping, Z., Dong, Q., Wang, Y., Fuling, Y., Yue, W., Liu, R., Yang, Y., Stetkarova, I., Mikulenka, P., Vasko, P., Peisker, T., Bar, M., Roubec, M., Mikulik, R., Cabukova, M., Vinklarek, J., Kovar, M., Pansky, M., Mencl, P., Skoda, O., Carek, M., Pernicka, M., Skodova, M., Geier, P., Cepkova, J., Drlik, J., Prax, T., Herzig, R., Krajickova, D., Vitkova, E., Haluskova, S., Vaclavik, D., Martinkova, J., Blejcharova, K., Tkacova, M., Pavlik, O., Nevšímalová, M., Rosol, J., Nevsimalova, M., Hruby, R., Iversen, H., Andersen, A.V., Rahimi, D., Christensen, H., Grundtvig, J., Hjort, N., Andersen, G., Sandal, B., Stilund, M., Modrau, B., Strade, A., Porobic, M., Andersen, S.D., Kruuse, C., Ölmestig, J., Kolmos, M., Parvez, A., Christensen, T., Stokholm, J., Jensen, H.B., Putaala, J., Strbian, D., Sibolt, G., Tiainen, M., Martinez-Majander, N., Curtze, S., Raty, S., Kraemer, Y., Roine, R., Aivo, J., Ruuskanen, J., Ylikotila, P., Roine, S., Hallikainen, M., Jakala, P., Kurl, S., Julkunen, V., Sibon, I., Olindo, S., Richard, S., Larrue, V., Gollion, C., Catala, H., Henon, H., Lucie, D.S., Nelly, D., Calvet, D., Malbranque, A., Mazé, B., Barbieux-Ghitu, C., Rosso, C., Samson, Y., Vannier, S., Moulin, T., Bonnet, L., Reiner, P., Buffon, F., Denier, C., Amri, K., Legris, N., Chassin, O., Selli, N., Mariana, S., Berrouschot, J., Stoll, A., Klunk, D., Keilitz, J., Neustadt, M., Zerrenner, S., Veltkamp, R., Hajjar, K., Heeger, A., Winezki, E., Apel, L., Pompsch, M., Mueller, P., Rappard, P., Auer, R., Ringleb, P.A., Berberich, A., Heyse, M., Mundiyanapurath, S., Reiff, T., Poli, S., Gomez-Exposito, A., Mengel, A., Tünnerhoff, J., Adeyemi, K., Poli, K., Kusch, V., Pelz, J., Michalski, D., Wartenberg, K., Althaus, K., Tavares, F., Mueller, S., Soda, H., Rascher, A., Hiermann, E., Weinhardt, R., Weissenborn, K., Leotescu, A., Grosse, G., Worthmann, H., Ernst, J., Gabriel, M., Schuppner, R., Schäfer, J.H., Charisse, D., Gruber, K., Kurka, N., Reitz, S.C., Pfeilschifter, W., Lee, J.I., Gliem, M., Moll, M., Steiner, T., Segura, L., Szegedi, N., Barandi, D., Uhrinakova, L., Czencz, M., Pasztor, M., Gyuker, N., Bartha, N.E., May, Z., Simony, Z., Szasz, G., Kakuk, I., Pető, N., Panczel, G.F., Olah, A., Racz, O., Balla, T., Horvath, B., Tuba, K., Czinderi, V., Klivenyi, P., Annus, A., Hertelendy, P., Szapary, L., Bosnyak, E., Kalmar, P., Karadi, Z., Cziba, L., Olah, L., Berki, A., Hudak, L., Kozák, M., Babel, S., Nemeth, L., Molnár, B., Simon, Z., Roveri, L., Cerri, F., Giacalone, G., Zini, A., Mauro, G., Asioli, G.M., Forlivesi, S., Arnone, G., Fiaccadori, A., Maria Fontana Francesca, E., Allegra, G., Mosconi, M.G., Longoni, M., Terlizzi, R., Paolucci, M., Tassi, R., Franci, B., Lucani, B., Domenichelli, C., Paoletti, D., Acampa, M., Zedde, M.L., Pezzella, F.R., Mangiardi, M., Galizia, P., Anticoli, S., Scalise, S., Lattanzi, S., Norata, D., Cannuccia, M., Cavallini, A., Federica, F., Denaro, M.F., Tosi, P., Sonoda, K., Kawajiri, M., Kusano, Y., Haraguchi, K., Kawano, H., Terasaki, T., Kaneko, C., Murase, S., Kumagai, M., Murai, N., Miyazaki, Y., Mori, T., Hatano, T., Kawanishi, M., Ochiai, J., Ishihara, S., Uehara, T., Yasaka, M., Nakagawa, H., Makino, M., Yonehara, T., Fukushima, Y., Hirotsune, N., Sakai, N., Yamasaki, M., Coutinho, J., Wouters, A., den Hertog, H., Zwartbol, R., Beumer, D., Kerklaan, J., Hilkens, P., Schreuder, T., Propper, D., Slowik, A., Wlodarczyk, E., Wrona, P., Pulyk, R., Lasek-Bal, A., Kosarz-Lanczek, K., Puz, P., Bilik, M., Magielska, A., Zamiela – Żółciak, A., Ochocinska, L., Bahdasaryan, S., Stępień, A., Dębiec, A., Joanna, K., Pawel, M., Jacek, S., Daniel, P., Marta, S., Rejdak, K., Wojczal, J., Luchowski, P., Fryze, W., Wisniewska, A., Krzyzanowska, M., Skowron, P., Wolosz, A., Galan, A., Grzymala, K., Krajewska, M., Nowak, R., Kłos, M., Cruz, V., Castro, P., Ferro, J., Canhão, P., Gouveia, R., Inácio, N., Rodrigues, M., Rachão, A., Ionel, C., Pereira, L., Viana-Baptista, M., Machado, C., Fernandes, C., Sargento, J., Inácio, N., Timchenko, L., Mironova, J., Zhadan, O., Torgashova, A., Bazhenova, O., Barashenkova, M., Kireeva, M., Romadina, N., Stepanova, I., Lenskaya, L., Lukinykh, L., Vorontsova, T., Agafina, A., Fedorova, A., Yashina, A., Alasheev, A., Smolkin, A., Prazdnichkova, E., Lutskovich, O., Gonysheva, Y., Mordvintseva, E., Nechaev, A., Martynova, E., Fedoraeva, N., Vishnyakova, T., Popov, D., Merzliakova, A., Margarita, K., Rechkalova, L., Ilyina, A., Kurenkova, N., Barbarash, O., Bazdyrev, E., Zvereva, T., Hromova, A., Morkvenas, A., Postnikova, E., Kovalenko, G., Taran, I., Pavlov, L., Ott, M., Chernitsova, N., Vodopyanova, N., Drozdova, E., Korebo, E., Lobanova, M., Lazareva, N., Snegova, N., Nikolaeva, O., Kolesnikov, Y., Kosheleva, Y., Krastev, G., Tomasova, K., Danis, M., Mako, M., Jankovicova, Z., Stevkova, Z., Kovacik, M., Kubikova, T., Jarosova, A., Serdahely, V., Cilingova, I., Pribulova, I., Sedlak, J., Slebodova, K., Paldaufova, M., Risnovsky, R., Berndtova, B., Urbanova, I., Junas, R., Karapetian, S., Gurcik, L., Vantrobova, A., Verbovsky, F., Vanacka, K., Ferenc, M., Galik, P., Bucakova, S., Ferencova, M., Kubalova, P., Boksanska, Z., Zacharova, E., Mahundi, E., Judita, H., Bachnak, M., Turcani, P., Kvasnicova Kamenska, A., Jurik, M., Vestenicka, V., Kycina, M., Sagatova, E., Dvorak, M., Hlubekova, A., Kucera, C., Gernath, L., Ferenc, M., Frimmelova, P., Slebodnikova, J., Aksteinerova, N., Horny, V., Gregova, Z., Segura, T., Romero, C., Ayo, O., Masjuan Vallejo, J., Cruz, A., De felipe, A, Matute, M.C., Garcia, S., Tembl Ferrairo, J., Vielba, I., Morales Caba, L., Molina, C., Garcia-Tornel García-Camba, Á., Requena Ruiz, M., Noelia, R., Rodriguez-Yañez, M., Rodriguez Castro, E., Lopez, I., Santamaria, M., Arias, S., Purroy García, F., Vázquez Justes, D., Mauri Capdevila, G., Vicente Pascual, M., Martí Fabregas, J., Camps Renom, P., Rodríguez Campello, A., Giralt, E., Krupinski, J., Molina, J., Trillo Senin, C. Ramos Martin, S., De La Fuente Sanz, E., Moniche, F., Manuel, M.R., Pardo, B., Martínez, I., Hernández Pérez, M., Arenillas Lara, J.F., De Lera, M., Egido, J.A., Gomez Escalonilla, C., Guillan, M., Martinez, J., Lindgren, A., Andsberg, G., Wictor, L., Leonidou, M., Stenman, M., Dalberg, N., Laska, A.C., Grünfeldt, A., Lundström, A., Nadzjafov, E., Rooth, E., Dalenbring, I., Sandén, P., Johansson, E., Thomas, G., Zietz, A.V., Rudin, S., Dittrich, T.D., Lilian, K., Kägi, G., Vehoff, J., Arnold, M., Scutelnic, A., Clénin, L., Beyeler, M., Madlaine, M., Maamari, B., Siepen, B., Vynckier, J., Tarnutzer, A., Bertschi, D., Luciani, M., Cereda, C., Maulucci, F., Bianco, G., Shairin, S., Pihan, H.A., Salmen, S., Quinn, T., McAlpine, C., Wright, F., Kalladka, D., Taylor, E., Sohaa, J., Brown, Z., Dawson, J., Cameron, A., Muir, S., Dima, S., Khan, U., Zhang, L., Warburton, E., Chatterjee, K., Nallasivan, A., Curran, D., Haider, S., Ghani, U., Kenton, A., Dallol, B., Mirza, M., Menezes, B., Davies, R., Robinson, T.G., Manning, L., Sztriha, L., Phinney, T., Sethi, P., Altafullah, I., Sharaf, A., Ostrander, M., Renati, S., Burgin, W.S., Olds, K., Delio, P., Malek, A., Dissin, J., Khatri, P., Flaherty, M., Demel, S., and Dofitas, S.

Published
2024
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6. Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

Author

Hideo Hagihara, Hirotaka Shoji, Satoko Hattori, Giovanni Sala, Yoshihiro Takamiya, Mika Tanaka, Masafumi Ihara, Mihiro Shibutani, Izuho Hatada, Kei Hori, Mikio Hoshino, Akito Nakao, Yasuo Mori, Shigeo Okabe, Masayuki Matsushita, Anja Urbach, Yuta Katayama, Akinobu Matsumoto, Keiichi I Nakayama, Shota Katori, Takuya Sato, Takuji Iwasato, Haruko Nakamura, Yoshio Goshima, Matthieu Raveau, Tetsuya Tatsukawa, Kazuhiro Yamakawa, Noriko Takahashi, Haruo Kasai, Johji Inazawa, Ikuo Nobuhisa, Tetsushi Kagawa, Tetsuya Taga, Mohamed Darwish, Hirofumi Nishizono, Keizo Takao, Kiran Sapkota, Kazutoshi Nakazawa, Tsuyoshi Takagi, Haruki Fujisawa, Yoshihisa Sugimura, Kyosuke Yamanishi, Lakshmi Rajagopal, Nanette Deneen Hannah, Herbert Y Meltzer, Tohru Yamamoto, Shuji Wakatsuki, Toshiyuki Araki, Katsuhiko Tabuchi, Tadahiro Numakawa, Hiroshi Kunugi, Freesia L Huang, Atsuko Hayata-Takano, Hitoshi Hashimoto, Kota Tamada, Toru Takumi, Takaoki Kasahara, Tadafumi Kato, Isabella A Graef, Gerald R Crabtree, Nozomi Asaoka, Hikari Hatakama, Shuji Kaneko, Takao Kohno, Mitsuharu Hattori, Yoshio Hoshiba, Ryuhei Miyake, Kisho Obi-Nagata, Akiko Hayashi-Takagi, Léa J Becker, Ipek Yalcin, Yoko Hagino, Hiroko Kotajima-Murakami, Yuki Moriya, Kazutaka Ikeda, Hyopil Kim, Bong-Kiun Kaang, Hikari Otabi, Yuta Yoshida, Atsushi Toyoda, Noboru H Komiyama, Seth GN Grant, Michiru Ida-Eto, Masaaki Narita, Ken-ichi Matsumoto, Emiko Okuda-Ashitaka, Iori Ohmori, Tadayuki Shimada, Kanato Yamagata, Hiroshi Ageta, Kunihiro Tsuchida, Kaoru Inokuchi, Takayuki Sassa, Akio Kihara, Motoaki Fukasawa, Nobuteru Usuda, Tayo Katano, Teruyuki Tanaka, Yoshihiro Yoshihara, Michihiro Igarashi, Takashi Hayashi, Kaori Ishikawa, Satoshi Yamamoto, Naoya Nishimura, Kazuto Nakada, Shinji Hirotsune, Kiyoshi Egawa, Kazuma Higashisaka, Yasuo Tsutsumi, Shoko Nishihara, Noriyuki Sugo, Takeshi Yagi, Naoto Ueno, Tomomi Yamamoto, Yoshihiro Kubo, Rie Ohashi, Nobuyuki Shiina, Kimiko Shimizu, Sayaka Higo-Yamamoto, Katsutaka Oishi, Hisashi Mori, Tamio Furuse, Masaru Tamura, Hisashi Shirakawa, Daiki X Sato, Yukiko U Inoue, Takayoshi Inoue, Yuriko Komine, Tetsuo Yamamori, Kenji Sakimura, and Tsuyoshi Miyakawa

Subjects
brain pH, lactate, metabolism, neuropsychiatric disorders, animal models, working memory, Medicine, Science, Biology (General), QH301-705.5
Abstract

Increased levels of lactate, an end-product of glycolysis, have been proposed as a potential surrogate marker for metabolic changes during neuronal excitation. These changes in lactate levels can result in decreased brain pH, which has been implicated in patients with various neuropsychiatric disorders. We previously demonstrated that such alterations are commonly observed in five mouse models of schizophrenia, bipolar disorder, and autism, suggesting a shared endophenotype among these disorders rather than mere artifacts due to medications or agonal state. However, there is still limited research on this phenomenon in animal models, leaving its generality across other disease animal models uncertain. Moreover, the association between changes in brain lactate levels and specific behavioral abnormalities remains unclear. To address these gaps, the International Brain pH Project Consortium investigated brain pH and lactate levels in 109 strains/conditions of 2294 animals with genetic and other experimental manipulations relevant to neuropsychiatric disorders. Systematic analysis revealed that decreased brain pH and increased lactate levels were common features observed in multiple models of depression, epilepsy, Alzheimer’s disease, and some additional schizophrenia models. While certain autism models also exhibited decreased pH and increased lactate levels, others showed the opposite pattern, potentially reflecting subpopulations within the autism spectrum. Furthermore, utilizing large-scale behavioral test battery, a multivariate cross-validated prediction analysis demonstrated that poor working memory performance was predominantly associated with increased brain lactate levels. Importantly, this association was confirmed in an independent cohort of animal models. Collectively, these findings suggest that altered brain pH and lactate levels, which could be attributed to dysregulated excitation/inhibition balance, may serve as transdiagnostic endophenotypes of debilitating neuropsychiatric disorders characterized by cognitive impairment, irrespective of their beneficial or detrimental nature.

Published
2024
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10. A Case of Intracranial Vertebral Artery Stenosis Treated with Percutaneous Transluminal Angioplasty and Stenting Guided by Brain Oximetry

Author

Okuma, Yu, Hirotsune, Nobuyuki, Ahmed, Umair, Miyara, Santiago J., Daido, Shigeru, Kagawa, Yukihide, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, Scholkmann, Felix, editor, LaManna, Joseph, editor, and Wolf, Ursula, editor

Published
2022
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11. DOPAnization of tyrosine in α-synuclein by tyrosine hydroxylase leads to the formation of oligomers

Author

Mingyue Jin, Sakiko Matsumoto, Takashi Ayaki, Hodaka Yamakado, Tomoyuki Taguchi, Natsuko Togawa, Ayumu Konno, Hirokazu Hirai, Hiroshi Nakajima, Shoji Komai, Ryuichi Ishida, Syuhei Chiba, Ryosuke Takahashi, Toshifumi Takao, and Shinji Hirotsune

Subjects
Science
Abstract

In this work, the authors show that α-synuclein is posttranslationally dopanized at Tyr136 by tyrosine hydroxylase, which facilitates the formation of oligomers. This modification likely impacts pathogenesis and the selective degeneration of dopaminergic neurons in Parkinson’s disease.

Published
2022
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13. Duration of fever and symptoms in influenza-infected children treated with baloxavir marboxil during the 2019–2020 season in Japan and detection of influenza virus with the PA E23K substitution

Author

Wagatsuma, Keita, Saito, Reiko, Chon, Irina, Phyu, Wint Wint, Fujio, Kakuya, Kawashima, Takashi, Sato, Isamu, Saito, Tadashi, Minato, Michiyoshi, Kodo, Naoki, Suzuki, Eitaro, Ono, Yasuhiko, Masaki, Hironori, Shirahige, Yutaka, Kitano, Akito, Hamabata, Hirotsune, Yuyang, Sun, Jiaming, Li, and Watanabe, Hisami

Published
2022
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14. Molecular Epidemiology of Respiratory Syncytial Virus during 2019–2022 and Surviving Genotypes after the COVID-19 Pandemic in Japan

Author

Sayaka Yoshioka, Wint Wint Phyu, Keita Wagatsuma, Takao Nagai, Yasuko Sano, Kiyosu Taniguchi, Nobuo Nagata, Kazuhiko Tomimoto, Isamu Sato, Harumi Kaji, Ken Sugata, Katsumi Sugiura, Naruo Saito, Satoshi Aoki, Eitaro Suzuki, Yasushi Shimada, Hirotsune Hamabata, Irina Chon, Teruhime Otoguro, Hisami Watanabe, and Reiko Saito

Subjects
respiratory syncytial virus, COVID-19 pandemic, molecular epidemiology, G gene, phylogeography, Microbiology, QR1-502
Abstract

To evaluate the changes in respiratory syncytial virus (RSV) collected between 2019 and 2022, we analyzed RSV-A and RSV-B strains from various prefectures in Japan before and after the COVID-19 pandemic. RT-PCR-positive samples collected from children with rapid test positivity at outpatient clinics in 11 prefectures in Japan were sequenced for the ectodomain of the G gene to determine the genotype. Time-aware phylogeographic analyses were performed using the second hypervariable region (HVR) of the G gene from 2012 to 2022. Of 967 samples, 739 (76.4%) were found to be RSV-positive using RT-PCR. RSV peaked in September 2019 but was not detected in 2020, except in Okinawa. Nationwide epidemics occurred with peaks in July 2021 and 2022. The genotype remained the same, ON1 for RSV-A and BA9 for RSV-B during 2019–2022. Phylogeographic analysis of HVR revealed that at least seven clusters of RSV-A had circulated previously but decreased to two clusters after the pandemic, whereas RSV-B had a single monophyletic cluster over the 10 years. Both RSV-A and RSV-B were transferred from Okinawa into other prefectures after the pandemic. The RSV epidemic was suppressed due to pandemic restrictions; however, pre-pandemic genotypes spread nationwide after the pandemic.

Published
2023
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15. Near-Infrared Spectroscopy Might Help Prevent Onset of Cerebral Hyperperfusion Syndrome

Author

Okuma, Yu, Hirotsune, Nobuyuki, Shinozaki, Koichiro, Yagi, Tsukasa, Kegoya, Yasuhito, Sotome, Yuta, Matsuda, Yuki, Sato, Yu, Tanabe, Tomoyuki, Muraoka, Kenichiro, Nishino, Shigeki, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, Nemoto, Edwin M., editor, Harrison, Eileen M., editor, Pias, Sally C., editor, Bragin, Denis E., editor, Harrison, David K., editor, and LaManna, Joseph C., editor

Published
2021
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16. Safety, Pharmacokinetics and Pharmacodynamics of DS-1040, in Combination with Thrombectomy, in Japanese Patients with Acute Ischemic Stroke

Author

Sakai, Nobuyuki, Takeuchi, Masataka, Imamura, Hirotoshi, Shimamura, Norihito, Yoshimura, Shinichi, Naito, Hiromichi, Kimura, Naoto, Masuo, Osamu, Hirotsune, Nobuyuki, Morita, Kenichi, Toyoda, Kazunori, Yamagami, Hiroshi, Ishihara, Hideyuki, Nakatsu, Takafumi, Miyoshi, Naoki, Suda, Miharu, and Fujimoto, Shigeru

Published
2022
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19. Nationwide and long-term molecular epidemiologic studies of mumps viruses that circulated in Japan between 1986 and 2017

Author

Minoru Kidokoro, Teiichiro Shiino, Tomohiro Yamaguchi, Eri Nariai, Hiroe Kodama, Keiko Nakata, Takako Sano, Keiko Gotou, Tomoko Kisu, Tomomi Maruyama, Yumani Kuba, Wakako Sakata, Teruaki Higashi, Naoko Kiyota, Takashi Sakai, Shunsuke Yahiro, Akira Nagita, Kaori Watanabe, Chika Hirokawa, Hirotsune Hamabata, Yoshiki Fujii, Miwako Yamamoto, Hajime Yokoi, Misako Sakamoto, Hiroyuki Saito, Chihiro Shibata, Machi Inada, Misako Fujitani, Hiroko Minagawa, Miyabi Ito, Akari Shima, Keiko Murano, Hiroshi Katoh, Fumihiro Kato, Makoto Takeda, Shigeru Suga, and The Surveillance Team for Mumps Virus in Japan

Subjects
mumps virus, molecular epidemiology, whole-genome sequencing, next-generation sequencing, phylogenetic analyses, genotype, Microbiology, QR1-502
Abstract

In Japan, major mumps outbreaks still occur every 4–5 years because of low mumps vaccine coverage (30–40%) owing to the voluntary immunization program. Herein, to prepare for a regular immunization program, we aimed to reveal the nationwide and long-term molecular epidemiological trends of the mumps virus (MuV) in Japan. Additionally, we performed whole-genome sequencing (WGS) using next-generation sequencing to assess results from conventional genotyping using MuV sequences of the small-hydrophobic (SH) gene. We analyzed 1,064 SH gene sequences from mumps clinical samples and MuV isolates collected from 25 prefectures from 1986 to 2017. The results showed that six genotypes, namely B (110), F (1), G (900), H (3), J (41), and L (9) were identified, and the dominant genotypes changed every decade in Japan since the 1980s. Genotype G has been exclusively circulating since the early 2000s. Seven clades were identified for genotype G using SH sequence-based classification. To verify the results, we performed WGS on 77 representative isolates of genotype G using NGS and phylogenetically analyzed them. Five clades were identified with high bootstrap values and designated as Japanese clade (JPC)-1, -2, -3, -4, -5. JPC-1 and -3 accounted for over 80% of the total genotype G isolates (68.3 and 13.8%, respectively). Of these, JPC-2 and -5, were newly identified clades in Japan through this study. This is the first report describing the nationwide and long-term molecular epidemiology of MuV in Japan. The results provide information about Japanese domestic genotypes, which is essential for evaluating the mumps elimination progress in Japan after the forthcoming introduction of the mumps vaccine into Japan’s regular immunization program. Furthermore, the study shows that WGS analysis using NGS is more accurate than results obtained from conventional SH sequence-based classification and is a powerful tool for accurate molecular epidemiology studies.

Published
2022
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21. Development of cycling probe based real-time PCR methodology for influenza A viruses possessing the PA/I38T amino acid substitution associated with reduced baloxavir susceptibility

Author

Osada, Hidekazu, Chon, Irina, Phyu, Wint Wint, Wagatsuma, Keita, Nagata, Nobuo, Kawashima, Takashi, Sato, Isamu, Saito, Tadashi, Kodo, Naoki, Masaki, Hironori, Asoh, Norichika, Tsuchihashi, Yoshiko, Shirahige, Yutaka, Ono, Yasuhiko, Shimada, Yasushi, Hamabata, Hirotsune, Saito, Kousuke, and Saito, Reiko

Published
2021
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27. Author Response: Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

Author

Hagihara, Hideo, primary, Shoji, Hirotaka, additional, Hattori, Satoko, additional, Sala, Giovanni, additional, Takamiya, Yoshihiro, additional, Tanaka, Mika, additional, Ihara, Masafumi, additional, Shibutani, Mihiro, additional, Hatada, Izuho, additional, Hori, Kei, additional, Hoshino, Mikio, additional, Nakao, Akito, additional, Mori, Yasuo, additional, Okabe, Shigeo, additional, Masayuki Matsushita, Masayuki, additional, Urbach, Anja, additional, Katayama, Yuta, additional, Matsumoto, Akinobu, additional, Nakayama, Keiichi I, additional, Katori, Shota, additional, Sato, Takuya, additional, Iwasato, Takuji, additional, Nakamura, Haruko, additional, Goshima, Yoshio, additional, Raveau, Matthieu, additional, Tatsukawa, Tetsuya, additional, Yamakawa, Kazuhiro, additional, Takahashi, Noriko, additional, Kasai, Haruo, additional, Inazawa, Johji, additional, Nobuhisa, Ikuo, additional, Kagawa, Tetsushi, additional, Taga, Tetsuya, additional, Darwish, Mohamed, additional, Nishizono, Hirofumi, additional, Takao, Keizo, additional, Sapkota, Kiran, additional, Nakazawa, Kazutoshi, additional, Takagi, Tsuyoshi, additional, Fujisawa, Haruki, additional, Sugimura, Yoshihisa, additional, Yamanishi, Kyosuke, additional, Rajagopal, Lakshmi, additional, Hannah, Nanette Deneen, additional, Meltzer, Herbert Y, additional, Yamamoto, Tohru, additional, Wakatsuki, Shuji, additional, Araki, Toshiyuki, additional, Tabuchi, Katsuhiko, additional, Numakawa, Tadahiro, additional, Kunugi, Hiroshi, additional, Huang, Freesia L, additional, Hayata-Takano, Atsuko, additional, Hashimoto, Hitoshi, additional, Tamada, Kota, additional, Takumi, Toru, additional, Kasahara, Takaoki, additional, Kato, Tadafumi, additional, Graef, Isabella A, additional, Crabtree, Gerry, additional, Asaoka, Nozomi, additional, Hatakama, Hikari, additional, Kaneko, Shuji, additional, Kohno, Takao, additional, Hattori, Mitsuharu, additional, Hoshiba, Yoshio, additional, Miyake, Ryuhei, additional, Obi-Nagata, Kisho, additional, Hayashi-Takagi, Akiko, additional, Becker, Léa J, additional, Yalcin, Ipek, additional, Hagino, Yoko, additional, Kotajima-Murakami, Hiroko, additional, Moriya, Yuki, additional, Ikeda, Kazutaka, additional, Kim, Hyopil, additional, Kaang, Bong-Kiun, additional, Otabi, Hikari, additional, Yoshida, Yuta, additional, Toyoda, Atsushi, additional, Komiyama, Noboru, additional, Grant, Seth GN, additional, Ida-Eto, Michiru, additional, Narita, Masaaki, additional, Matsumoto, Ken-ichi, additional, Okuda-Ashitaka, Emiko, additional, Ohmori, Iori, additional, Shimada, Tadayuki, additional, Yamagata, Kanato, additional, Ageta, Hiroshi, additional, Tsuchida, Kunihiro, additional, Inokuchi, Kaoru, additional, Sassa, Takayuki, additional, Kihara, Akio, additional, Fukasawa, Motoaki, additional, Usuda, Nobuteru, additional, Katano, Tayo, additional, Tanaka, Teruyuki, additional, Yoshihara, Yoshihiro, additional, Igarashi, Michihiro, additional, Hayashi, Takashi, additional, Ishikawa, Kaori, additional, Yamamoto, Satoshi, additional, Nishimura, Naoya, additional, Nakada, Kazuto, additional, Hirotsune, Shinji, additional, Egawa, Kiyoshi, additional, Higashisaka, Kazuma, additional, Tsutsumi, Yasuo, additional, Nishihara, Shoko, additional, Sugo, Noriyuki, additional, Yagi, Takeshi, additional, Ueno, Naoto, additional, Yamamoto, Tomomi, additional, Kubo, Yoshihiro, additional, Ohashi, Rie, additional, Shiina, Nobuyuki, additional, Shimizu, Kimiko, additional, Higo-Yamamoto, Sayaka, additional, Oishi, Katsutaka, additional, Mori, Hisashi, additional, Furuse, Tamio, additional, Tamura, Masaru, additional, Shirakawa, Hisashi, additional, Sato, Daiki X, additional, Inoue, Yukiko U, additional, Inoue, Takayoshi, additional, Komine, Yuriko, additional, Yamamori, Tetsuo, additional, Sakimura, Kenji, additional, and Miyakawa, Tsuyoshi, additional

Published
2024
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28. Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

Author

Hagihara, Hideo, primary, Shoji, Hirotaka, additional, Hattori, Satoko, additional, Sala, Giovanni, additional, Takamiya, Yoshihiro, additional, Tanaka, Mika, additional, Ihara, Masafumi, additional, Shibutani, Mihiro, additional, Hatada, Izuho, additional, Hori, Kei, additional, Hoshino, Mikio, additional, Nakao, Akito, additional, Mori, Yasuo, additional, Okabe, Shigeo, additional, Matsushita, Masayuki, additional, Urbach, Anja, additional, Katayama, Yuta, additional, Matsumoto, Akinobu, additional, Nakayama, Keiichi I, additional, Katori, Shota, additional, Sato, Takuya, additional, Iwasato, Takuji, additional, Nakamura, Haruko, additional, Goshima, Yoshio, additional, Raveau, Matthieu, additional, Tatsukawa, Tetsuya, additional, Yamakawa, Kazuhiro, additional, Takahashi, Noriko, additional, Kasai, Haruo, additional, Inazawa, Johji, additional, Nobuhisa, Ikuo, additional, Kagawa, Tetsushi, additional, Taga, Tetsuya, additional, Darwish, Mohamed, additional, Nishizono, Hirofumi, additional, Takao, Keizo, additional, Sapkota, Kiran, additional, Nakazawa, Kazutoshi, additional, Takagi, Tsuyoshi, additional, Fujisawa, Haruki, additional, Sugimura, Yoshihisa, additional, Yamanishi, Kyosuke, additional, Rajagopal, Lakshmi, additional, Hannah, Nanette Deneen, additional, Meltzer, Herbert Y, additional, Yamamoto, Tohru, additional, Wakatsuki, Shuji, additional, Araki, Toshiyuki, additional, Tabuchi, Katsuhiko, additional, Numakawa, Tadahiro, additional, Kunugi, Hiroshi, additional, Huang, Freesia L, additional, Hayata-Takano, Atsuko, additional, Hashimoto, Hitoshi, additional, Tamada, Kota, additional, Takumi, Toru, additional, Kasahara, Takaoki, additional, Kato, Tadafumi, additional, Graef, Isabella A, additional, Crabtree, Gerald R, additional, Asaoka, Nozomi, additional, Hatakama, Hikari, additional, Kaneko, Shuji, additional, Kohno, Takao, additional, Hattori, Mitsuharu, additional, Hoshiba, Yoshio, additional, Miyake, Ryuhei, additional, Obi-Nagata, Kisho, additional, Hayashi-Takagi, Akiko, additional, Becker, Léa J, additional, Yalcin, Ipek, additional, Hagino, Yoko, additional, Kotajima-Murakami, Hiroko, additional, Moriya, Yuki, additional, Ikeda, Kazutaka, additional, Kim, Hyopil, additional, Kaang, Bong-Kiun, additional, Otabi, Hikari, additional, Yoshida, Yuta, additional, Toyoda, Atsushi, additional, Komiyama, Noboru H, additional, Grant, Seth GN, additional, Ida-Eto, Michiru, additional, Narita, Masaaki, additional, Matsumoto, Ken-ichi, additional, Okuda-Ashitaka, Emiko, additional, Ohmori, Iori, additional, Shimada, Tadayuki, additional, Yamagata, Kanato, additional, Ageta, Hiroshi, additional, Tsuchida, Kunihiro, additional, Inokuchi, Kaoru, additional, Sassa, Takayuki, additional, Kihara, Akio, additional, Fukasawa, Motoaki, additional, Usuda, Nobuteru, additional, Katano, Tayo, additional, Tanaka, Teruyuki, additional, Yoshihara, Yoshihiro, additional, Igarashi, Michihiro, additional, Hayashi, Takashi, additional, Ishikawa, Kaori, additional, Yamamoto, Satoshi, additional, Nishimura, Naoya, additional, Nakada, Kazuto, additional, Hirotsune, Shinji, additional, Egawa, Kiyoshi, additional, Higashisaka, Kazuma, additional, Tsutsumi, Yasuo, additional, Nishihara, Shoko, additional, Sugo, Noriyuki, additional, Yagi, Takeshi, additional, Ueno, Naoto, additional, Yamamoto, Tomomi, additional, Kubo, Yoshihiro, additional, Ohashi, Rie, additional, Shiina, Nobuyuki, additional, Shimizu, Kimiko, additional, Higo-Yamamoto, Sayaka, additional, Oishi, Katsutaka, additional, Mori, Hisashi, additional, Furuse, Tamio, additional, Tamura, Masaru, additional, Shirakawa, Hisashi, additional, Sato, Daiki X, additional, Inoue, Yukiko U, additional, Inoue, Takayoshi, additional, Komine, Yuriko, additional, Yamamori, Tetsuo, additional, Sakimura, Kenji, additional, and Miyakawa, Tsuyoshi, additional

Published
2024
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31. p-adic Eisenstein-Kronecker series and non-critical values of p-adic Hecke L-functions of an Imaginary Quadratic Field when the conductor is divisible by p

Author

Hirotsune, Tomoki

Subjects
Mathematics - Number Theory, 11F85, 11R42, 14G10, 11G55
Abstract

We relate non-critical special values $p$-adic $L$-functions associated to algebraic Hecke characters of an imaginary quadratic number field with class number one to $p$-adic Coleman function called the $p$-adic Eisenstein-Kronecker series, when the conductors of the algebraic Hecke characters are divisible by $p$., Comment: 24 pages

Published
2013

33. Successful conservative treatment of cesarean scar ectopic pregnancy with local injections of absolute ethanol

Author

Toshiyuki Kakinuma, Kaoru Kakinuma, Yoshio Matsuda, Kaoru Yanagida, Hirotsune Kaijima, and Michitaka Ohwada

Subjects
absolute ethanol local injection, cesarean scar ectopic pregnancies, cesarean scar, ectopic pregnancies, transvaginal ultrasound, Gynecology and obstetrics, RG1-991
Abstract

Cesarean scar ectopic pregnancy (CSEP) is becoming more common worldwide. Here, we report a case of cesarean scar pregnancy successfully treated using transvaginal ethanol injection. A 31-year-old female (gravida 3, para 2) with two prior cesarean sections presented at 9 weeks and 3 days of pregnancy. Her serum human chorionic gonadotropin level was 91,798 mIU/mL. CSEP was confirmed by transvaginal ultrasonography, pelvic magnetic resonance imaging, and color Doppler ultrasonography. Transvaginal absolute ethanol local injection under transvaginal ultrasound guidance was performed. She was discharged 7 days after treatment with no complications and resumed normal menses 1 month after treatment. We describe a safe and successful treatment option for CSEP.

Published
2021
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38. A Unique Case of Intracranial Amelanotic Melanoma with BRAF V600E Mutation Successfully Treated via Molecular-targeted Therapy

Author

FUJITA, Juntaro, primary, TOMITA, Yusuke, additional, ICHIMURA, Koichi, additional, YAMASAKI, Rie, additional, NISHIGAKI, Shohei, additional, NITTA, Yuki, additional, INOUE, Yusuke, additional, SOTOME, Yuta, additional, KIDANI, Naoya, additional, MURAOKA, Kenichiro, additional, HIROTSUNE, Nobuyuki, additional, and NISHINO, Shigeki, additional

Published
2023
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39. Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

Author

Hagihara, Hideo, primary, Shoji, Hirotaka, additional, Hattori, Satoko, additional, Sala, Giovanni, additional, Takamiya, Yoshihiro, additional, Tanaka, Mika, additional, Ihara, Masafumi, additional, Shibutani, Mihiro, additional, Hatada, Izuho, additional, Hori, Kei, additional, Hoshino, Mikio, additional, Nakao, Akito, additional, Mori, Yasuo, additional, Okabe, Shigeo, additional, Matsushita, Masayuki, additional, Urbach, Anja, additional, Katayama, Yuta, additional, Matsumoto, Akinobu, additional, Nakayama, Keiichi I., additional, Katori, Shota, additional, Sato, Takuya, additional, Iwasato, Takuji, additional, Nakamura, Haruko, additional, Goshima, Yoshio, additional, Raveau, Matthieu, additional, Tatsukawa, Tetsuya, additional, Yamakawa, Kazuhiro, additional, Takahashi, Noriko, additional, Kasai, Haruo, additional, Inazawa, Johji, additional, Nobuhisa, Ikuo, additional, Kagawa, Tetsushi, additional, Taga, Tetsuya, additional, Darwish, Mohamed, additional, Nishizono, Hirofumi, additional, Takao, Keizo, additional, Sapkota, Kiran, additional, Nakazawa, Kazutoshi, additional, Takagi, Tsuyoshi, additional, Fujisawa, Haruki, additional, Sugimura, Yoshihisa, additional, Yamanishi, Kyosuke, additional, Rajagopal, Lakshmi, additional, Hannah, Nanette Deneen, additional, Meltzer, Herbert Y., additional, Yamamoto, Tohru, additional, Wakatsuki, Shuji, additional, Araki, Toshiyuki, additional, Tabuchi, Katsuhiko, additional, Numakawa, Tadahiro, additional, Kunugi, Hiroshi, additional, Huang, Freesia L., additional, Hayata-Takano, Atsuko, additional, Hashimoto, Hitoshi, additional, Tamada, Kota, additional, Takumi, Toru, additional, Kasahara, Takaoki, additional, Kato, Tadafumi, additional, Graef, Isabella A., additional, Crabtree, Gerald R., additional, Asaoka, Nozomi, additional, Hatakama, Hikari, additional, Kaneko, Shuji, additional, Kohno, Takao, additional, Hattori, Mitsuharu, additional, Hoshiba, Yoshio, additional, Miyake, Ryuhei, additional, Obi-Nagata, Kisho, additional, Hayashi-Takagi, Akiko, additional, Becker, Léa J., additional, Yalcin, Ipek, additional, Hagino, Yoko, additional, Kotajima-Murakami, Hiroko, additional, Moriya, Yuki, additional, Ikeda, Kazutaka, additional, Kim, Hyopil, additional, Kaang, Bong-Kiun, additional, Otabi, Hikari, additional, Yoshida, Yuta, additional, Toyoda, Atsushi, additional, Komiyama, Noboru H., additional, Grant, Seth G. N., additional, Ida-Eto, Michiru, additional, Narita, Masaaki, additional, Matsumoto, Ken-ichi, additional, Okuda-Ashitaka, Emiko, additional, Ohmori, Iori, additional, Shimada, Tadayuki, additional, Yamagata, Kanato, additional, Ageta, Hiroshi, additional, Tsuchida, Kunihiro, additional, Inokuchi, Kaoru, additional, Sassa, Takayuki, additional, Kihara, Akio, additional, Fukasawa, Motoaki, additional, Usuda, Nobuteru, additional, Katano, Tayo, additional, Tanaka, Teruyuki, additional, Yoshihara, Yoshihiro, additional, Igarashi, Michihiro, additional, Hayashi, Takashi, additional, Ishikawa, Kaori, additional, Yamamoto, Satoshi, additional, Nishimura, Naoya, additional, Nakada, Kazuto, additional, Hirotsune, Shinji, additional, Egawa, Kiyoshi, additional, Higashisaka, Kazuma, additional, Tsutsumi, Yasuo, additional, Nishihara, Shoko, additional, Sugo, Noriyuki, additional, Yagi, Takeshi, additional, Ueno, Naoto, additional, Yamamoto, Tomomi, additional, Kubo, Yoshihiro, additional, Ohashi, Rie, additional, Shiina, Nobuyuki, additional, Shimizu, Kimiko, additional, Higo-Yamamoto, Sayaka, additional, Oishi, Katsutaka, additional, Mori, Hisashi, additional, Furuse, Tamio, additional, Tamura, Masaru, additional, Shirakawa, Hisashi, additional, Sato, Daiki X., additional, Inoue, Yukiko U., additional, Inoue, Takayoshi, additional, Komine, Yuriko, additional, Yamamori, Tetsuo, additional, Sakimura, Kenji, additional, and Miyakawa, Tsuyoshi, additional

Published
2023
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40. Author Response: Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

Author

Hagihara, Hideo, primary, Shoji, Hirotaka, additional, Hattori, Satoko, additional, Sala, Giovanni, additional, Takamiya, Yoshihiro, additional, Tanaka, Mika, additional, Ihara, Masafumi, additional, Shibutani, Mihiro, additional, Hatada, Izuho, additional, Hori, Kei, additional, Hoshino, Mikio, additional, Nakao, Akito, additional, Mori, Yasuo, additional, Okabe, Shigeo, additional, Matsushita, Masayuki, additional, Urbach, Anja, additional, Katayama, Yuta, additional, Matsumoto, Akinobu, additional, Nakayama, Keiichi I., additional, Katori, Shota, additional, Sato, Takuya, additional, Iwasato, Takuji, additional, Nakamura, Haruko, additional, Goshima, Yoshio, additional, Raveau, Matthieu, additional, Tatsukawa, Tetsuya, additional, Yamakawa, Kazuhiro, additional, Takahashi, Noriko, additional, Kasai, Haruo, additional, Inazawa, Johji, additional, Nobuhisa, Ikuo, additional, Kagawa, Tetsushi, additional, Taga, Tetsuya, additional, Darwish, Mohamed, additional, Nishizono, Hirofumi, additional, Takao, Keizo, additional, Sapkota, Kiran, additional, Nakazawa, Kazutoshi, additional, Takagi, Tsuyoshi, additional, Fujisawa, Haruki, additional, Sugimura, Yoshihisa, additional, Yamanishi, Kyosuke, additional, Rajagopal, Lakshmi, additional, Hannah, Nanette Deneen, additional, Meltzer, Herbert Y., additional, Yamamoto, Tohru, additional, Wakatsuki, Shuji, additional, Araki, Toshiyuki, additional, Tabuchi, Katsuhiko, additional, Numakawa, Tadahiro, additional, Kunugi, Hiroshi, additional, Huang, Freesia L., additional, Hayata-Takano, Atsuko, additional, Hashimoto, Hitoshi, additional, Tamada, Kota, additional, Takumi, Toru, additional, Kasahara, Takaoki, additional, Kato, Tadafumi, additional, Graef, Isabella A., additional, Crabtree, Gerald R., additional, Asaoka, Nozomi, additional, Hatakama, Hikari, additional, Kaneko, Shuji, additional, Kohno, Takao, additional, Hattori, Mitsuharu, additional, Hoshiba, Yoshio, additional, Miyake, Ryuhei, additional, Obi-Nagata, Kisho, additional, Hayashi-Takagi, Akiko, additional, Becker, Léa J., additional, Yalcin, Ipek, additional, Hagino, Yoko, additional, Kotajima-Murakami, Hiroko, additional, Moriya, Yuki, additional, Ikeda, Kazutaka, additional, Kim, Hyopil, additional, Kaang, Bong-Kiun, additional, Otabi, Hikari, additional, Yoshida, Yuta, additional, Toyoda, Atsushi, additional, Komiyama, Noboru H., additional, Grant, Seth G. N., additional, Ida-Eto, Michiru, additional, Narita, Masaaki, additional, Matsumoto, Ken-ichi, additional, Okuda-Ashitaka, Emiko, additional, Ohmori, Iori, additional, Shimada, Tadayuki, additional, Yamagata, Kanato, additional, Ageta, Hiroshi, additional, Tsuchida, Kunihiro, additional, Inokuchi, Kaoru, additional, Sassa, Takayuki, additional, Kihara, Akio, additional, Fukasawa, Motoaki, additional, Usuda, Nobuteru, additional, Katano, Tayo, additional, Tanaka, Teruyuki, additional, Yoshihara, Yoshihiro, additional, Igarashi, Michihiro, additional, Hayashi, Takashi, additional, Ishikawa, Kaori, additional, Yamamoto, Satoshi, additional, Nishimura, Naoya, additional, Nakada, Kazuto, additional, Hirotsune, Shinji, additional, Egawa, Kiyoshi, additional, Higashisaka, Kazuma, additional, Tsutsumi, Yasuo, additional, Nishihara, Shoko, additional, Sugo, Noriyuki, additional, Yagi, Takeshi, additional, Ueno, Naoto, additional, Yamamoto, Tomomi, additional, Kubo, Yoshihiro, additional, Ohashi, Rie, additional, Shiina, Nobuyuki, additional, Shimizu, Kimiko, additional, Higo-Yamamoto, Sayaka, additional, Oishi, Katsutaka, additional, Mori, Hisashi, additional, Furuse, Tamio, additional, Tamura, Masaru, additional, Shirakawa, Hisashi, additional, Sato, Daiki X., additional, Inoue, Yukiko U., additional, Inoue, Takayoshi, additional, Komine, Yuriko, additional, Yamamori, Tetsuo, additional, Sakimura, Kenji, additional, and Miyakawa, Tsuyoshi, additional

Published
2023
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41. Molecular Epidemiology of Respiratory Syncytial Virus during 2019–2022 and Surviving Genotypes after the COVID-19 Pandemic in Japan

Author

Yoshioka, Sayaka, primary, Phyu, Wint Wint, additional, Wagatsuma, Keita, additional, Nagai, Takao, additional, Sano, Yasuko, additional, Taniguchi, Kiyosu, additional, Nagata, Nobuo, additional, Tomimoto, Kazuhiko, additional, Sato, Isamu, additional, Kaji, Harumi, additional, Sugata, Ken, additional, Sugiura, Katsumi, additional, Saito, Naruo, additional, Aoki, Satoshi, additional, Suzuki, Eitaro, additional, Shimada, Yasushi, additional, Hamabata, Hirotsune, additional, Chon, Irina, additional, Otoguro, Teruhime, additional, Watanabe, Hisami, additional, and Saito, Reiko, additional

Published
2023
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42. Technical notes on deploying a LVIS stent – The importance of push and pull passively depending on the catheter torque

Author

Yu Okuma, Nobuyuki Hirotsune, Yuta Sotome, Yasuhito Kegoya, Yuki Matsuda, Yu Sato, Ittetsu Kin, Hayato Takeuchi, Tomoyuki Tanabe, Kenichiro Muraoka, Shigeki Nishino, and Shigeru Daido

Subjects
Low-profile visualized intraluminal support (LVIS), Dry lab training, Incomplete stent deployment, Surgery, RD1-811, Neurology. Diseases of the nervous system, RC346-429
Abstract

Objective: Low-profile visualized intraluminal support (LVIS®) is a braided stent utilized for stent-assisted coil embolization of intracranial aneurysms. In this report, we review the technical notes of coil embolization for unruptured intracranial aneurysm using LVIS® stents. Case description: We reported six consecutive cases of unruptured saccular aneurysm of the internal carotid artery all of whom underwent stent-assisted coil embolization with the LVIS® stent. After the first three cases, dry lab training using a complicated parent artery model allowed us to determine how to effectively place an LVIS® stent and to shorten operative time significantly. All patients were followed up for at least 1 year after the procedure. Thus far, none of the patients have experienced recurrence or complications. Conclusions: Our experience with patients undergoing stent-assisted coil embolization using LVIS® stents before and after dry lab training reveal that several simple technical tips, including careful measurement of the parent artery diameter, choice of an appropriate stent size, and evasion of pushing or pulling the stent beyond what is necessary, are important for easy and stable deployment of LVIS® stents.

Published
2021
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49. Successful Retrieval of Filter Embolic Protection Device Fragment Trapped by a Carotid Stent: A Case Report.

Author

Jun Karakama, Mariko Ishikawa, Sakyo Hirai, Satoru Takahashi, Hikaru Wakabayashi, Hirotaka Sagawa, Shoko Fujii, Kyohei Fujita, Nobuyuki Hirotsune, and Kazutaka Sumita

Subjects
CAROTID artery stenosis, SURGICAL stents, NEUROLOGY, SURGICAL complications, CAROTID artery diseases
Abstract

Objective: Embolic protection devices are useful for preventing distal embolism during carotid artery stenting (CAS); however, complications have been reported. The successful removal of a filter fragment trapped at the distal edge of a carotid stent during the retrieval procedure is described. Case Presentation: CAS was performed for internal carotid artery stenosis in a patient in his 70s, and the carotid stent was successfully placed. During the retrieval procedure, the tip of the filter was trapped at the distal edge of the stent and detached from the filter. Using a snare kit, the filter tip was successfully retrieved, and no postoperative neurological symptoms occurred. Conclusion: The edge of a carotid stent can potentially trap devices. When trapping or fragmentation of a device is suspected, it is necessary to evaluate the situation and cause, and the device should be appropriately retrieved without using force. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Secondary normal pressure hydrocephalus following pituitary apoplexy: A case report.

Author

Yusuke Tomita, Shoichi Fukuda, Aiko Kobashi, Yoshihiro Okada, Keigo Makino, Naoya Kidani, Kenichiro Muraoka, Nobuyuki Hirotsune, and Shigeki Nishino

Subjects
CENTRAL nervous system diseases, CEREBROSPINAL fluid leak, HORMONE therapy, MAGNETIC resonance imaging, LOSS of consciousness
Abstract

Background: Although secondary normal pressure hydrocephalus (sNPH) can occur in various central nervous system diseases, there are no reports of sNPH caused by pituitary lesions. Herein, we present a unique case of sNPH caused by pituitary apoplexy. Case Description: A 70-year-old man was transferred to our hospital because of a sudden onset of headache and loss of consciousness. The cerebrospinal fluid (CSF) test showed slightly elevated cell counts and protein levels but a negative CSF culture test. Magnetic resonance imaging showed a dumbbell-like cystic lesion with hemorrhagic change at the sella turcica. From the above, the patient was diagnosed with aseptic meningitis caused by pituitary apoplexy. Pituitary hormone replacement therapy was undertaken, and his symptoms fully improved. However, two months later, he complained of a gait disturbance and incontinence that had gradually appeared. Brain imaging with computed tomography showed no ventricular enlargement compared with initial images, although the lateral ventricles were slightly enlarged. As a CSF drainage test improved his symptoms temporarily, sNPH with possible longstanding overt ventriculomegaly in adults (LOVA) background was suspected. We performed a lumboperitoneal shunt (LPS) placement, which improved his symptoms. Conclusion: This case suggests that sNPH can develop even after a small subarachnoid hemorrhage caused by a pituitary apoplexy in LOVA patients. If the aqueduct of Sylvius is open, sNPH with a LOVA background can be successfully treated with LPS placement. [ABSTRACT FROM AUTHOR]

Published
2024
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