8,917 results on '"A., Siani"'
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2. Syphilitic hepatitis in infants, the forgotten disease that hepatologists have to brush up on: from a case series to a revision of literature
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Delle Cave, Valeria, Zito Marinosci, Geremia, Ferrara, Dolores, Esposito, Francesco, Lo Vecchio, Andrea, Sciveres, Marco, Mandato, Claudia, De Brasi, Daniele, Siani, Paolo, and Ranucci, Giusy
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- 2024
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3. Measuring and Improving Care in Surgical Site Infections
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Bartoli, Stefano, Ianni, Giulia, Castrucci, Tommaso, Gabrielli, Roberto, Siani, Andrea, Bellandi, Tommaso, Bartoli, Stefano, editor, Cortese, Francesco, editor, Sartelli, Massimo, editor, and Sganga, Gabriele, editor
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- 2025
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4. Guidelines and Good Clinical Practice in Surgical Infection
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Bartoli, Stefano, Ianni, Giulia, Smedile, Gianluca, Castrucci, Tommaso, Siani, Andrea, Bartoli, Stefano, editor, Cortese, Francesco, editor, Sartelli, Massimo, editor, and Sganga, Gabriele, editor
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- 2025
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5. Infection Control in Prosthetic Surgery
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Ianni, Giulia, Pizza, Francesco, Siani, Andrea, Castrucci, Tommaso, Accrocca, Federico, Bartoli, Stefano, Bartoli, Stefano, editor, Cortese, Francesco, editor, Sartelli, Massimo, editor, and Sganga, Gabriele, editor
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- 2025
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6. Finding $d$-Cuts in Graphs of Bounded Diameter, Graphs of Bounded Radius and $H$-Free Graphs
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Lucke, Felicia, Momeni, Ali, Paulusma, Daniël, and Smith, Siani
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Mathematics - Combinatorics ,Computer Science - Computational Complexity ,Computer Science - Discrete Mathematics ,Computer Science - Data Structures and Algorithms - Abstract
The $d$-Cut problem is to decide if a graph has an edge cut such that each vertex has at most $d$ neighbours at the opposite side of the cut. If $d=1$, we obtain the intensively studied Matching Cut problem. The $d$-Cut problem has been studied as well, but a systematic study for special graph classes was lacking. We initiate such a study and consider classes of bounded diameter, bounded radius and $H$-free graphs. We prove that for all $d\geq 2$, $d$-Cut is polynomial-time solvable for graphs of diameter $2$, $(P_3+P_4)$-free graphs and $P_5$-free graphs. These results extend known results for $d=1$. However, we also prove several NP-hardness results for $d$-Cut that contrast known polynomial-time results for $d=1$. Our results lead to full dichotomies for bounded diameter and bounded radius and to almost-complete dichotomies for $H$-free graphs.
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- 2024
7. Graph Homomorphism, Monotone Classes and Bounded Pathwidth
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Eagling-Vose, Tala, Martin, Barnaby, Paulusma, Daniel, Siggers, Mark, and Smith, Siani
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Computer Science - Computational Complexity ,Computer Science - Logic in Computer Science - Abstract
A recent paper describes a framework for studying the computational complexity of graph problems on monotone classes, that is those omitting a set of graphs as a subgraph. If the problems lie in the framework, and many do, then the computational complexity can be described for all monotone classes defined by a finite set of omitted subgraphs. It is known that certain homomorphism problems, e.g. $C_5$-Colouring, do not sit in the framework. By contrast, we show that the more general problem of Graph Homomorphism does sit in the framework. The original framework had examples where hard versus easy were NP-complete versus P, or at least quadratic versus almost linear. We give the first example of a problem in the framework such that hardness is in the polynomial hierarchy above NP. Considering a variant of the colouring game as studied by Bodlaender, we show that with the restriction of bounded alternation, the list version of this problem is contained in the framework. The hard cases are $\Pi_{2k}^\mathrm{P}$-complete and the easy cases are in P. The cases in P comprise those classes for which the pathwidth is bounded. Bodlaender explains that Sequential $3$-Colouring Construction Game is in P on classes with bounded vertex separation number, which coincides with bounded pathwidth on unordered graphs. However, these graphs are ordered with a playing order for the two players, which corresponds to a prefix pattern in a quantified formula. We prove that Sequential $3$-Colouring Construction Game is Pspace-complete on some class of bounded pathwidth, using a celebrated result of Atserias and Oliva. We consider several locally constrained variants of the homomorphism problem. Like $C_5$-Colouring, none of these is in the framework. However, when we consider the bounded-degree restrictions, we prove that each of these problems is in our framework.
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- 2024
8. Fe-Ti Oxide Mineralization in the XV Intrusion, Bafq Mining District, Central Iran: Insights from Mineralogy, Mineral Chemistry and S Isotopic Data
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Amraei, Sakine, Siani, Majid Ghasemi, Yazdi, Mohammad, Qiu, Liang, Moine, Bertrand, and Ren, Minghua
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- 2024
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9. Evaluating Operation Good Food & Beverages, a Black Youth-Driven Public Advocacy Campaign
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Kearney, Matthew D., Eaton, Tiffany M., Grabill, Megan, Anderson, Siani, and Kumanyika, Shiriki
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- 2024
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10. Climate-induced risk assessment of the quarantine room in a University Library
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Boccacci, Giulia, Frasca, Francesca, Bertolin, Chiara, Chimenti, Claudio, Lund, Erlend, Saeter, Tonje Dahlin, and Siani, Anna Maria
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- 2024
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11. Assessment of the urban pollution island intensity in Rome (Italy) from in-situ PM measurements
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Di Bernardino, Annalisa, Erriu, Margherita, Argentini, Stefania, Campanelli, Monica, Casasanta, Giampietro, Cecilia, Andrea, Falasca, Serena, and Siani, Anna Maria
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- 2024
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12. Assessing microclimate thresholds for heritage preventive conservation to achieve sustainable and energy efficiency goals in a changing climate
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Frasca, Francesca, Verticchio, Elena, Bosco, Emanuela, Kuka, Edgars, Lee, Daniel Sang-Hoon, Andersen, Cecil Krarup, Bertolin, Chiara, and Siani, Anna Maria
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- 2024
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13. Susceptibility to scientific misinformation and perception of news source reliability in secondary school students
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Siani, Alessandro, Joseph, Maria, and Dacin, Claudiu
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- 2024
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14. Understanding Muslim consumers’ purchase intentions toward counterfeit sporting goods
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Mohammadi, Sardar, Ghasemi Siani, Mojtaba, and Dickson, Geoff
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- 2024
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15. Axiomatization of some power indices in voting games with abstention
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Siani, Joseph, Tchantcho, Bertrand, and Tsague, Bill Proces
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- 2024
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16. Complexity Framework for Forbidden Subgraphs IV: The Steiner Forest Problem
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Bodlaender, Hans L., Johnson, Matthew, Martin, Barnaby, Oostveen, Jelle J., Pandey, Sukanya, Paulusma, Daniel, Smith, Siani, and van Leeuwen, Erik Jan
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Mathematics - Combinatorics ,Computer Science - Computational Complexity ,Computer Science - Discrete Mathematics ,Computer Science - Data Structures and Algorithms - Abstract
We study Steiner Forest on $H$-subgraph-free graphs, that is, graphs that do not contain some fixed graph $H$ as a (not necessarily induced) subgraph. We are motivated by a recent framework that completely characterizes the complexity of many problems on $H$-subgraph-free graphs. However, in contrast to e.g. the related Steiner Tree problem, Steiner Forest falls outside this framework. Hence, the complexity of Steiner Forest on $H$-subgraph-free graphs remained tantalizingly open. In this paper, we make significant progress towards determining the complexity of Steiner Forest on $H$-subgraph-free graphs. Our main results are four novel polynomial-time algorithms for different excluded graphs $H$ that are central to further understand its complexity. Along the way, we study the complexity of Steiner Forest for graphs with a small $c$-deletion set, that is, a small set $S$ of vertices such that each component of $G-S$ has size at most $c$. Using this parameter, we give two noteworthy algorithms that we later employ as subroutines. First, we prove Steiner Forest is FPT parameterized by $|S|$ when $c=1$ (i.e. the vertex cover number). Second, we prove Steiner Forest is polynomial-time solvable for graphs with a 2-deletion set of size at most 2. The latter result is tight, as the problem is NP-complete for graphs with a 3-deletion set of size 2.
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- 2023
17. Complexity Framework for Forbidden Subgraphs III: When Problems are Tractable on Subcubic Graphs
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Johnson, Matthew, Martin, Barnaby, Pandey, Sukanya, Paulusma, Daniël, Smith, Siani, and van Leeuwen, Erik Jan
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Computer Science - Data Structures and Algorithms ,Mathematics - Combinatorics - Abstract
For any finite set $\mathcal{H} = \{H_1,\ldots,H_p\}$ of graphs, a graph is $\mathcal{H}$-subgraph-free if it does not contain any of $H_1,\ldots,H_p$ as a subgraph. In recent work, meta-classifications have been studied: these show that if graph problems satisfy certain prescribed conditions, their complexity is determined on classes of $\mathcal{H}$-subgraph-free graphs. We continue this work and focus on problems that have polynomial-time solutions on classes that have bounded treewidth or maximum degree at most~$3$ and examine their complexity on $H$-subgraph-free graph classes where $H$ is a connected graph. With this approach, we obtain comprehensive classifications for (Independent) Feedback Vertex Set, Connected Vertex Cover, Colouring and Matching Cut. This resolves a number of open problems. We highlight that, to establish that Independent Feedback Vertex Set belongs to this collection of problems, we first show that it can be solved in polynomial time on graphs of maximum degree $3$. We demonstrate that, with the exception of the complete graph on four vertices, each graph in this class has a minimum size feedback vertex set that is also an independent set.
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- 2023
18. Assessing microclimate thresholds for heritage preventive conservation to achieve sustainable and energy efficiency goals in a changing climate
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Francesca Frasca, Elena Verticchio, Emanuela Bosco, Edgars Kuka, Daniel Sang-Hoon Lee, Cecil Krarup Andersen, Chiara Bertolin, and Anna Maria Siani
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SDGs ,Changing climate ,Heritage preventive conservation ,Standard ,Degradation models ,Collections facilities ,Medicine ,Science - Abstract
Abstract This research addresses the issue of the heritage preventive conservation in the perspective of energy sustainability, for contributing to the achievement of the Sustainable Development Goals (SDGs) and towards the EU Green Deal. The study analyses and compares four cases associated with different microclimate thresholds as suggested by the standard EN 16893:2018 (Cases 1–3) and as derived from the outputs of three degradation models for preserving paper, wood, and canvas paintings (Case 4). Weather-based indices (degree and gram days) were calculated to estimate trends in the potential energy demand of collection facilities in three European cities belonging to different Köppen-Geiger climate zones (Cfb, Csa, and Dfb), under recent past (1981–2010) and near/far future climate scenarios (2021–2050 and 2071–2100) from two Shared Socioeconomic Pathways (SSP2-4.5 and SSP5-8.5). The findings suggest that adapting facilities’ management strategies to focus on collections preservation can facilitate the achievement of 5 out of 17 SDGs, offering a viable alternative to costly energy retrofits and encouraging the development of shared solutions for similar facilities in the same climate zone. The results can contribute to inform the revision of EN 16893 and to face major challenges such as the preservation of paper collections in southern latitudes.
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- 2024
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19. Evolution in European and Israeli School Curricula -- A Comparative Analysis
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Evangelia Mavrikaki, Giulia Realdon, Tuomas Aivelo, Ani Bajrami, Çiçek Dilek Bakanay, Anna Beniermann, Jelena Blagojevic, Egle Butkeviciene, Bento Cavadas, Costantina Cossu, Dragana Cvetkovic, Szymon M. Drobniak, Zelal Özgür Durmus, Radka Marta Dvoráková, Marcel Eens, Esra Eret, Seckin Eroglu, Malgorzata Anna Gazda, Martha Georgiou, Neil J. Gostling, Tanja Gregorcic, Vanda Janštová, Tania Jenkins, Anttoni Kervinen, Konstantinos Korfiatis, Paul Kuschmierz, Ádám Z. Lendvai, Joelyn de Lima, Fundime Miri, Teresa Nogueira, Andreas Panayides, Sylvia Paolucci, Penelope Papadopoulou, Patrícia Pessoa, Rianne Pinxten, Joana Rios Rocha, Andrea Fernández Sánchez, Merav Siani, Elvisa Sokoli, Bruno Sousa, Panagiotis K. Stasinakis, Gregor Torkar, Asta Valackiene, Máté Varga, Lucía Vázquez Ben, Anat Yarden, and Xana Sá-Pinto
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The contribution of school curricula to public understanding and acceptance of evolution is still mostly unknown, due to the scarcity of studies that compare the learning goals present in different curricula. To overcome this lack of data we analysed 19 school curricula (18 European and one from Israel) to study the differences regarding the inclusion of learning goals targeting evolution understanding. We performed a quantitative content analysis using the Framework for the Assessment of school Curricula on the presence of Evolutionary concepts (FACE). For each country/region we analysed what this educational system considered the minimum evolution education a citizen should get. Our results reveal that: (i) the curricula include less than half of the learning goals considered important for scientific literacy in evolution; (ii) the most frequent learning goals address basic knowledge of evolution; (iii) learning goals related with the processes that drive evolution are often not included or rarely mentioned; (iv) evolution is most often not linked to its applications in everyday life. These results highlight the need to rethink evolution education across Europe.
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- 2024
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20. Possible Connections between Knowledge and Acceptance of Evolution amongst Jewish Religious Preservice Science Teachers Who Learned about Human Evolution
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Merav Siani and Anat Yarden
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Evolution is a fundamental part of biology and thus it is essential that biology preservice teachers understand and accept it. The relationship between knowledge and acceptance of evolution, and specifically human evolution, has not been fully investigated in Israel. We sought to learn about that relationship amongst Israeli Jewish religious preservice science teachers. Twenty-three religious preservice teachers answered knowledge questions before and after participating in a human evolution activity and completed an acceptance questionnaire (I-SEA). In addition, eleven of them were interviewed regarding their knowledge of evolution and four were interviewed regarding their acceptance of evolution a few months after participating in the activity. Our main findings were that the relationship between knowledge and acceptance of evolution was not always one-to-one. The preservice teachers whose evolution knowledge is high and have firm religious faith accept the theory of evolution and are willing and eager to teach it. In addition, preservice teachers might have made a shift in their understanding of human evolution and thus accepted human evolution more due to the activity. More teacher training and exposure to evolution content and pedagogy are needed so that when preservice teachers will become in-service teachers they will teach evolution without hesitance.
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- 2024
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21. Susceptibility to Scientific Misinformation and Perception of News Source Reliability in Secondary School Students
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Alessandro Siani, Maria Joseph, and Claudiu Dacin
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In the current post-truth era, the ability to assess the reliability of information is an essential citizenship attribute. With nearly half of the present internet traffic estimated to be generated by bots, and misinformation being regularly weaponised by numerous parties for economic or political gain, it is imperative that citizens are equipped with the tools to discriminate facts from fiction, particularly for health- and science-related matters. The present study reports the results of a survey (n = 776) carried out to evaluate susceptibility to scientific misinformation and perception of news source reliability amongst students in an English secondary school. Two distinct scores were developed in order to differentially measure susceptibility to disinformation (i.e. deliberately false information) and unintentional misinformation (i.e. getting the facts wrong). Non-parametric analysis indicated that students' misinformation (as measured by both scores) decreased significantly over the course of the 5 years of secondary education. Interestingly, the adolescents who took part in the survey exhibited considerably lower belief in common science-based conspiracy theories than the levels previously reported among British adults. Students indicated teachers as their most frequent choice of scientific news. While social media were also indicated as common news sources, students expressed awareness of the unreliability of the content available on social media. Analysis of the open answers indicated that students considered BBC as the most trustworthy source of scientific information, and TikTok as the least trustworthy.
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- 2024
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22. You'll Learn to Love It? Examining the Relationship between Intervention Dose and Acceptability among Third-Grade Students
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Tanya L. Eckert, Samantha C. Maguire, Kaytlin A. Nelson, Siani Y. M. Amidon, Alec R. Goldstein, Monique S. Antoine, Joshua J. Circe, Sophia V. Alderman, and Tyler J. Young
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The acceptability of school-based interventions has been regularly examined among teachers and parents; however, students are less frequently assessed despite being the recipients of most interventions. Although recent studies have begun exploring how different student characteristics (e.g., gender) and types of acceptability assessments (e.g., dynamic) impact students' ratings, no studies have examined the role of intervention dosage despite early conceptual models highlighting the linkage between intervention acceptability, dosage, adherence, and effectiveness. This study explored 255 third-grade students' intervention dosage and acceptability ratings within the context of a class-wide writing intervention administered over 7 weeks. Results indicated that most students received a high number of intervention sessions throughout the study and rated the intervention as moderately acceptable. There was a statistically significant gender difference in students' postintervention acceptability ratings, with female students rating the class-wide writing intervention higher than male students. In addition, intervention dosage was a statistically significant predictor of students' postintervention acceptability ratings, although gender did not moderate these findings.
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- 2024
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23. Teaching Immunology in the 21st Century: A Scoping Review of Emerging Challenges and Strategies
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Merav Siani, Ilana Dubovi, Anna Borushko, and Michal Haskel-Ittah
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Immunology, a complex and rapidly evolving biological field, serves dual educational goals: training healthcare professionals and immunologists as well as promoting immune literacy among laypeople. This study conducted a scoping review of the literature to explore different aspects of immunology education, examining various contexts, levels, and content areas, including cognitive and motivational challenges. In addition, analysis covered different teaching strategies and research methodologies. Eight hundred and seventy-four articles were screened, and 20 articles proceeded to full-text analysis. Notably, the majority of the analysed studies concentrated on undergraduate education, emphasising strategies for teaching immunology, with a heavy reliance on quantitative research methods. Teaching strategies that were influential for improving the knowledge of the students were, for example, using games, using simulations and visualisations, using hands on experiments and self-directed learning. The content of the reviewed articles primarily revolved around topics related to innate and adaptive immunity, basic immunology, and immune system diseases. There was less emphasis on advanced immunology and on addressing the inherent complexity of the subject and even less on methods to motivate students to engage with immunology. Practical implications and suggestions for future research are described considering both healthcare practitioner training and immune literacy for laypeople.
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- 2024
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24. The Militancy of Kinship, Intimacy, and Religion
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Bolotta, Giuseppe and Siani, Edoardo
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Alter-politics. Intimacy. Kinship. Religion. Social movements. Southeast Asia ,Languages and literature of Eastern Asia, Africa, Oceania ,PL1-8844 - Abstract
What are the specific features of political dissent in Southeast Asia? And how may scholarly insights from the region contribute to the study of social movements in other world areas? In this article, we scrutinize the florescence of social activism in contemporary Southeast Asia by bringing together examples of popular protest in countries as diverse as Burma/Myanmar, Thailand, the Philippines, Vietnam, and Indonesia, as well as in transnational arenas of mobilization that connect local struggles to globally relevant issues and forms of dissent. We discuss applications of social movements literature to specific Southeast Asian historical, political and socio-cultural modernities, arguing that anthropological scholarship, postcolonial and feminist theory, as well as the social scientific study of power ontologies in non-western societies, are necessary references to expand our understanding of social movements in the region. We simultaneously advance that Southeast Asian expressions of dissent often double as “alter-politics”, or alternative re-imaginings of the common good. Their study benefits from careful examination of situational arrangements of power in specific locales, with particular attention to domains of feeling, thought and practice that are commonly deemed as apolitical in modern political philosophy: intimacy, religion, and kinship. With this essay, we finally aim to treat Southeast Asia as a site for the production rather than the mere reception of theories of resistance.
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- 2024
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25. Creatine and improvement in cognitive function: Evaluation of a health claim pursuant to article 13(5) of regulation (EC) No 1924/2006
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EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan deHenauw, Karen‐Ildico Hirsch‐Ernst, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Frank Thies, Ionut Craciun, Thibault Fiolet, and Alfonso Siani
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cognition ,cognitive function ,Creatine ,health claim ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract Following an application from Alzchem Trostberg GmbH, submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Austria, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on the scientific substantiation of a health claim related to creatine and improvement in cognitive function. The Panel considers that the food constituent, creatine, is sufficiently characterised. An improvement in cognitive function in one or more of its domains is a beneficial physiological effect. The applicant identified 21 human intervention studies on creatine supplementation and measures of cognitive function through a literature search. Two additional studies published after the search was conducted were identified through the reference list of a meta‐analysis. In weighing the evidence, the Panel took into account that the acute effect of creatine on working memory, observed in two studies at 20 g/day for 5–7 days, was not seen at lower doses (2.2–14 g/day), or with continuous consumption (5 g/day for 6 weeks following a 5‐day loading phase). Furthermore, the effect on response inhibition at 20 g/day for 7 days was an isolated finding among 10 intervention studies in healthy individuals, with no effects observed on other cognitive domains. The Panel also considered that the three intervention studies conducted in diseased individuals do not support an effect of creatine supplementation on cognition, and that the available evidence for a mechanism by which creatine could exert the claimed effect is weak. The Panel concludes that a cause‐and‐effect relationship has not been established between creatine supplementation and an improvement in cognitive function in one or more of its domains.
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- 2024
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26. Safety of Tiger nuts (Cyperus esculentus) oil as a novel food pursuant to Regulation (EU) 2015/2283
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EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch‐Ernst, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Margarita Aguilera‐Gómez, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Helle Katrine Knutsen, Monika Neuhäuser‐Berthold, Morten Poulsen, Miguel Prieto Maradona, Josef Rudolf Schlatter, Alexandros Siskos, Henk vanLoveren, Fernando Rivero‐Pino, Ruth Roldán‐Torres, and Harry J. McArdle
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Cyperus esculentus ,isolated from or produced from a plant ,novel foods ,oleic acid ,safety ,tiger nut oil ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on the safety of Tiger nuts (Cyperus esculentus) oil as a novel food (NF) pursuant to Regulation (EU) 2015/2283. Tiger nuts (C. esculentus) is an edible tuber with history of consumption as food. The NF is the oil obtained from the nuts through cold pressing of the seeds flour. Oleic acid is the major component, representing 65%–69% of the oil's total fatty acids. The applicant proposed to use the NF as an ingredient in several food categories, and as a cooking oil or added as a condiment. The Panel notes that there are no safety concerns regarding stability if the NF complies with the proposed specification limits during its entire shelf‐life. Taking into consideration the composition of the NF and the proposed conditions of use, the consumption of the NF is not nutritionally disadvantageous. The Panel considers that, based on the production process, composition of the NF, history of use of and composition of the source, no toxicological studies are required on the NF. The Panel concludes that the NF is safe under the proposed conditions of use.
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- 2024
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27. Guidance for establishing and applying tolerable upper intake levels for vitamins and essential minerals
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EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan deHenauw, Karen‐Ildico Hirsch‐Ernst, Angeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Kristina Pentieva, Alfonso Siani, Frank Thies, Peter Aggett, Marta Crous‐Bou, Francesco Cubadda, Aymeric Dopter, Susan Fairweather‐Tait, Georg Lietz, Harry J. McArdle, Giovanni Passeri, Marco Vinceti, Misha Vrolijk, Ionut Craciun, Agnès deSesmaisons Lecarré, Zsuzsanna Horvath, Laura Martino, Silvia Valtueña Martinez, and Androniki Naska
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dietary reference value ,mineral ,tolerable upper intake level ,UL ,vitamin ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract Vitamins and essential minerals are micronutrients that are required for the normal functioning of the human body. However, they may lead to adverse health effects if consumed in excess. A tolerable upper intake level (UL) is a science‐based reference value that supports policy‐makers and other relevant actors in managing the risks of excess nutrient intake. EFSA's principles for establishing ULs for vitamins and minerals were originally developed by the Scientific Committee on Food in 2000. This guidance from the EFSA Panel on Nutrition, Novel Foods and Food Allergens provides an updated framework for UL assessments. A draft was published in 2022 and underwent a 2‐year piloting period. The present document incorporates revisions based on the experience gained through its practical implementation. It covers aspects related to the planning of the risk assessment (problem formulation and definition of methods) and its implementation (evidence retrieval, appraisal, synthesis, integration, uncertainty analysis). As in the previous framework, the general principles developed for the risk assessment of chemicals in food are applied, i.e. hazard identification, hazard characterisation, intake assessment, risk characterisation. Specific to nutrients are their biochemical and physiological roles and the specific and selective mechanisms that maintain the systemic homeostasis and accumulation of the nutrient in the body. Such considerations must also be taken into account when conducting risk assessments of nutrients.
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- 2024
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28. Gender Balance and Impact of Role Models in Secondary Science Education
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Siani, Alessandro, McArthur, Megan, Hicks, Bethany Christine, and Dacin, Claudiu
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Exposure to inspirational and relatable role models is crucial towards fostering engagement of learners with scientific disciplines. However, the representation of scientists in popular culture is still far from being adequately gender- and race-inclusive. This study evaluated the gender balance and impact of scientific role models using a two-pronged experimental approach. The gender balance was investigated in search engines, online databases, and school curricula. A survey was used to investigate English secondary students' awareness of role models and intentions to pursue further scientific studies. Our findings revealed a widespread female underrepresentation amongst scientific role models in all the analysed online sources and in high school curricula provided by the three main English exam boards. The survey (??=356) revealed that students were considerably more likely to identify famous male than female scientists. While awareness of female role models was significantly associated with students' gender, this was not the case for male role models. A statistically significant correlation was also observed between the number of identified role models and intentions to pursue scientific studies in Key Stage 4 girls. This study reinforces the urgency of ensuring school curricula and online resources provide a more modern and inclusive representation of scientists.
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- 2022
29. Complexity Framework for Forbidden Subgraphs II: Edge Subdivision and the 'H'-graphs
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Lozin, Vadim, Martin, Barnaby, Pandey, Sukanya, Paulusma, Daniel, Siggers, Mark, Smith, Siani, and van Leeuwen, Erik Jan
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Computer Science - Discrete Mathematics ,Mathematics - Combinatorics - Abstract
For a fixed set ${\cal H}$ of graphs, a graph $G$ is ${\cal H}$-subgraph-free if $G$ does not contain any $H \in {\cal H}$ as a (not necessarily induced) subgraph. A recently proposed framework gives a complete classification on ${\cal H}$-subgraph-free graphs (for finite sets ${\cal H}$) for problems that are solvable in polynomial time on graph classes of bounded treewidth, NP-complete on subcubic graphs, and whose NP-hardness is preserved under edge subdivision. While a lot of problems satisfy these conditions, there are also many problems that do not satisfy all three conditions and for which the complexity in ${\cal H}$-subgraph-free graphs is unknown. We study problems for which only the first two conditions of the framework hold (they are solvable in polynomial time on classes of bounded treewidth and NP-complete on subcubic graphs, but NP-hardness is not preserved under edge subdivision). In particular, we make inroads into the classification of the complexity of four such problems: Hamilton Cycle, $k$-Induced Disjoint Paths, $C_5$-Colouring and Star $3$-Colouring. Although we do not complete the classifications, we show that the boundary between polynomial time and NP-complete differs among our problems and also from problems that do satisfy all three conditions of the framework, in particular when we forbid certain subdivisions of the ``H''-graph (the graph that looks like the letter ``H''). Hence, we exhibit a rich complexity landscape among problems for ${\cal H}$-subgraph-free graph classes.
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- 2022
30. Complexity Framework For Forbidden Subgraphs I: The Framework
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Johnson, Matthew, Martin, Barnaby, Oostveen, Jelle J., Pandey, Sukanya, Paulusma, Daniël, Smith, Siani, and van Leeuwen, Erik Jan
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Mathematics - Combinatorics ,Computer Science - Computational Complexity ,Computer Science - Discrete Mathematics ,Computer Science - Data Structures and Algorithms - Abstract
For any particular class of graphs, algorithms for computational problems restricted to the class often rely on structural properties that depend on the specific problem at hand. This begs the question if a large set of such results can be explained by some common problem conditions. We propose such conditions for $HH$-subgraph-free graphs. For a set of graphs $HH$, a graph $G$ is $HH$-subgraph-free if $G$ does not contain any of graph from $H$ as a subgraph. Our conditions are easy to state. A graph problem must be efficiently solvable on graphs of bounded treewidth, computationally hard on subcubic graphs, and computational hardness must be preserved under edge subdivision of subcubic graphs. Our meta-classification says that if a graph problem satisfies all three conditions, then for every finite set $HH$, it is ``efficiently solvable'' on $HH$-subgraph-free graphs if $HH$ contains a disjoint union of one or more paths and subdivided claws, and is ``computationally hard'' otherwise. We illustrate the broad applicability of our meta-classification by obtaining a dichotomy between polynomial-time solvability and NP-completeness for many well-known partitioning, covering and packing problems, network design problems and width parameter problems. For other problems, we obtain a dichotomy between almost-linear-time solvability and having no subquadratic-time algorithm (conditioned on some hardness hypotheses). The proposed framework thus gives a simple pathway to determine the complexity of graph problems on $HH$-subgraph-free graphs. This is confirmed even more by the fact that along the way, we uncover and resolve several open questions from the literature.
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- 2022
31. Edge Multiway Cut and Node Multiway Cut are NP-complete on subcubic graphs
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Johnson, Matthew, Martin, Barnaby, Smith, Siani, Pandey, Sukanya, Paulusma, Daniel, and van Leeuwen, Erik Jan
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Computer Science - Computational Complexity ,Computer Science - Discrete Mathematics ,Computer Science - Data Structures and Algorithms - Abstract
We show that Edge Multiway Cut (also called Multiterminal Cut) and Node Multiway Cut are NP-complete on graphs of maximum degree $3$ (also known as subcubic graphs). This improves on a previous degree bound of $11$. Our NP-completeness result holds even for subcubic graphs that are planar., Comment: Appeared in Proceedings of SWAT 2024
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- 2022
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32. Hearing loss prevention at loud music events via real-time visuo-haptic feedback
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Turchet, Luca, Luiten, Simone, Treub, Tjebbe, van der Burgt, Marloes, Siani, Costanza, and Boem, Alberto
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- 2024
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33. Tumor enlargement in adrenal incidentaloma is related to glaucoma: a new prognostic feature?
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Caputo, M., Daffara, T., Ferrero, A., Romanisio, M., Monti, E., Mele, C., Zavattaro, M., Tricca, S., Siani, A., Clemente, A., Palumbo, C., De Cillà, S., Carriero, A., Volpe, A., Marzullo, P., Aimaretti, G., and Prodam, F.
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- 2024
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34. Magnetometric geophysical studies in Khosrow Abad iron deposit, northeast of Sonqor (Kermanshah Province)
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Behzad Mehrabi, Majid Ghasemi Siani, Hamed Ebrahimi Fard, Elnaz Geravandi, and Ebrahim Shahin
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magnetometry ,depth estimation ,modeling of magnetic anomalies ,khosrow abad ,Geology ,QE1-996.5 - Abstract
Khosro Abad iron ore deposit is located 130 km of Kermanshah, 30 km northeast of Sonqor city close to Khosro Abad village, in the Sanandaj-Sirjan zone. Based on the field observation, exposed units in the area include; basaltic-andesite volcanic rocks and limestone of the Sonqor Volcanic-Sedimentary Complex. The quartz-monzonite body intruded the sequence and caused a contact metamorphism of up to greenschist facies, and development of hydrothermal alteration halos. Discharged iron bearing hydrothermal fluid destabilized due to physicochemical changes and deposited the iron ore in the contact of limestone, basaltic-andesite and quartz-monzonite intrusion. Control of iron ore mineralization by the contact of quartz-monzonite and volcano-sedimentary sequence and presence of skarn mineralogy is evidence of skarn mineralization in Khosrow Abad. Geophysical survey was carried out using magnetometry technique (1305 stations), covering an area of 3.6 Km2 for defining the high potential areas of iron mineralization and depth estimation. In this research, total magnetic, reduction to pole, analytical signal, and upward continuation maps were prepared, and based on the obtained results four anomaly blocks of; An(A)-An(A´)-An(B)-An(C) were identified. An(C) anomaly is shallower than the others and extend approximately down to 50 meters, while other anomalies are much deeper. The maximum magnetic anomaly in total field intensity and RTP maps is 46426.1 and 49474.6 nanotesla, respectively, along a northeast-southwest trend, aligned with the contact of meta-andesite-basalt and crystallized limestone units. Introduction The magnetometric exploration technique is one of the low-cost, widely used, and indirect methods for mineral exploration and tracking of oxidizing intrusive bodies containing Fe-Ti oxides, such as magnetite, titanomagnetite, and titanohematite, as well as some iron sulfides such as pyrrhotite (Donohue et al., 2012). The Khosrow Abad iron ore deposit is located in west Iran’s iron metallogenic zone of the Sonqor series. It is located northwest of the Sanandaj-Sirjan zone; northeast of the Sonqor town (Kermanshah province) (Ghorbani, 2007) in Sonqor-Baneh volcanic belt (Azizi and Moinevaziri, 2009). In the northeast of Sonqor, hypabyssal acidic intrusive bodies penetrated the Upper Jurassic rock units, including basaltic meta-andesite volcanic rocks and limy slates (calc-shale), causing skarn development and iron ore mineralization. Mineralization is mainly hosted in the meta basaltic andesite unit's skarn zone, differentiating it from other common carbonate-hosted skarn deposits (e.g., Ebrahimi Fard et al., 2022a; Ebrahimi Fard et al., 2022b). The main purpose of current research is to examine the magnetometric geophysical explorations' accuracy in detecting possible ore zones as well as the depth of oxidized (magnetic) intrusive bodies and current emplacement depth and possible associated mineralization. The main challenges were locating the magnetite ore zone covered by recent alluvium and ore zone has limited exposure, and skarn ore facies without classic carbonates as a host rock. Calc-silicate minerals in association with oxide and sulfide minerals formed the skarn zones in the Khosrow Abad deposit. Magnetite, pyrite, chalcopyrite, garnet, clinopyroxene, sodic plagioclase (albite), actinolite, epidote, chlorite, calcite, quartz, and iron hydroxides such as hematite, goethite, and limonite are the main constitute of the skarn zones. The main fracture system in the Khosrow Abad is a large strike-slip fault with an approximately north-south (NNW-SSE) trend and more than 80 degrees dip towards the east. Iron ore mineralization is mainly located in the eastern edge of this fault which formed a shear zone in the metamorphosed volcanic unit. Material and methods Based on the geological map, field observations, geological structures, mineralization limited exposure, and geophysical exploration were carried out perpendicular to apparent structures (probable veins and faults trend) along the northwest-southeast direction. The exploration pattern of the survey was, 25 10 m (profile distance of 25 m and 10 m reading intervals) in the ore zone and a 20 25 m pattern in surrounding rocks (1350 stations). Measurements were carried out by a Proton magnetometer model G856 manufactured by Geometrics. Magnetic surveys were mainly focused on meta basaltic andesite and quartz monzonite units. Qualitative and quantitative data processing and interpretations of data were carried out by using Geosoft Oasis Montaj and Magmap software. The highest field intensity recorded in the area is 52049 nT and the lowest recorded is 43619 nT, which according to the IGRF of 47515nT, is possibly due to the changes caused by the presence of medium-grade magnetite mineralization. Discussion In the total magnetic intensity map, magnetic anomalies were detected with the northwest-southeast trend which is related to discontinuous lenses along the main fault. In the IGRF-REM map, the maximum intensity value of anomalies is equal to 4534 nanotesla. All 4 detected anomalies; (A), (A´), (B), and (C) are high-intensity anomalies in this range. Anomaly (C) is marked on the map with moderate to relatively weak intensity. The upward continuation map indicates that the ore zone continues at least to a depth of more than 70 meters. The Euler's deconvolution method shows an estimate of the anomaly depth, An(C) anomaly is shallower than the others and has a depth of about 50 meters. Based on Spector and Grant's method, the estimated depth of Khosrow Abad iron ore mineralization is about 0.03 km, which is a reasonable estimate. The minimum depth of anomalies in most areas is about 30 meters. The model prepared by Encom Quickmag software shows that linear anomalies are located in line with the regional faults and parallel to each other with medium depth. For validation of the modeling results, based on the data interpretation (analytical signal map, pole-to-pole map, and transversal continuation), several drilling points were proposed for borehole drilling. Conclusion Based on the geophysical data processing and interpretation (analytical signal map, reduction to pole map, and upward continuation) as well as modeling results, several locations were proposed for borehole drilling. The BH-1 borehole is located in the An (A) block anomaly central point, and according to the core logging data, this anomaly is introduced as an anomaly with good intensity, and according to the continuation map with a depth of more than 30 meters is almost match the geophysical interpretation and model. After the drilling campaign, it was discovered that geophysical prediction shows a good agreement with the drilling data, which confirms the effectiveness of the proper design and implemented geophysical survey for iron ore exploration in the Khosrow Abad deposit, which could be used for other skarn iron ore deposits of the region.
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- 2024
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35. Multi-scale modeling of folic acid-functionalized TiO$_{2}$ nanoparticles for active targeting of tumor cells
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Donadoni, Edoardo, Siani, Paulo, Frigerio, Giulia, and Di Valentin, Cristiana
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Condensed Matter - Materials Science - Abstract
Strategies based on the active targeting of tumor cells are emerging as smart and efficient nanomedical procedures. Folic acid (FA) is a vitamin and a well-established tumor targeting agent because of its strong affinity for the folate receptor (FR), which is an overexpressed protein on the cell membranes of the tumor cells. FA can be successfully anchored to several nanocarriers, including inorganic nanoparticles (NPs) based on transition metal oxides. Among them, TiO$_{2}$ is extremely interesting because of its excellent photoabsorption and photocatalytic properties, which can be exploited in photodynamic therapy. However, it is not yet clear in which respects direct anchoring of FA to the NP or the use of spacers, based on polyethylene glycol (PEG) chains, are different and whether one approach is better than the other. In this work, we combine Quantum Mechanics (QM) and Classical Molecular Dynamics (MD) to design and optimize the FA functionalization on bare and PEGylated TiO$_{2}$ models and to study the dynamical behavior of the resulting nanoconjugates in pure water environment and in physiological conditions. We observe that they are chemically stable, even under the effect of increasing temperature (up to 500 K). Using the results from long MD simulations (100 ns) and from free energy calculations, we determine how the density of FA molecules on the TiO$_{2}$ NP and the presence of PEG spacers impact on the actual exposure of the ligands, especially by affecting the extent of FA-FA intermolecular interactions, which are detrimental for the targeting ability of FA towards the folate receptor. This analysis provides a solid and rational basis for experimentalists to define the optimal FA density and the more appropriate mode of anchoring to the carrier, according to the final purpose of the nanoconjugate.
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- 2022
36. Complexity Framework for Forbidden Subgraphs II: Edge Subdivision and the 'H'-Graphs.
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Vadim V. Lozin, Barnaby Martin, Sukanya Pandey, Daniël Paulusma, Mark H. Siggers, Siani Smith, and Erik Jan van Leeuwen
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- 2024
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37. Edge Multiway Cut and Node Multiway Cut Are Hard for Planar Subcubic Graphs.
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Matthew Johnson 0002, Barnaby Martin, Sukanya Pandey, Daniël Paulusma, Siani Smith, and Erik Jan van Leeuwen
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- 2024
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38. Graph Homomorphism, Monotone Classes and Bounded Pathwidth.
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Tala Eagling-Vose, Barnaby Martin, Daniël Paulusma, and Siani Smith
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- 2024
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39. A Numerical Comparison of Deeply Quantized Models for sEMG Hand Gesture Classification on Constrained Devices.
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Emanuele Giuseppe Siani, Laura Scigliano, Dario Bruneo, Fabrizio De Vita, Valeria Tomaselli, and Danilo Pau
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- 2024
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40. Complexity Framework for Forbidden Subgraphs IV: The Steiner Forest Problem.
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Hans L. Bodlaender, Matthew Johnson 0002, Barnaby Martin, Jelle J. Oostveen, Sukanya Pandey, Daniël Paulusma, Siani Smith, and Erik Jan van Leeuwen
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- 2024
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41. Impact of the COVID-19 Pandemic on Teaching, Learning, Assessment, and Wellbeing in Higher Education
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Siani, Alessandro, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, and Rosenhouse-Dantsker, Avia, Editorial Board Member
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- 2024
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42. A Review of Global Inequities in COVID-19 Vaccination Access and Uptake
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Siani, Alessandro, Rezaei, Nima, Editor-in-Chief, and Son, Barbara W. K., editor
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- 2024
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43. Complexity Framework for Forbidden Subgraphs IV: The Steiner Forest Problem
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Bodlaender, Hans L., Johnson, Matthew, Martin, Barnaby, Oostveen, Jelle J., Pandey, Sukanya, Paulusma, Daniël, Smith, Siani, van Leeuwen, Erik Jan, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Rescigno, Adele Anna, editor, and Vaccaro, Ugo, editor
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- 2024
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44. DigitalBamboo_Algorithmic Design with Bamboo and Other Vegetable Rods
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Pollak, Stefan, Siani, Rossella, Chaari, Fakher, Series Editor, Gherardini, Francesco, Series Editor, Ivanov, Vitalii, Series Editor, Haddar, Mohamed, Series Editor, Cavas-Martínez, Francisco, Editorial Board Member, di Mare, Francesca, Editorial Board Member, Kwon, Young W., Editorial Board Member, Trojanowska, Justyna, Editorial Board Member, Xu, Jinyang, Editorial Board Member, Barberio, Maurizio, editor, Colella, Micaela, editor, Figliola, Angelo, editor, and Battisti, Alessandra, editor
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- 2024
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45. Moderate-to-vigorous physical activity modulates the association between serum 25-hydroxyvitamin D and bone stiffness in European children and adolescents
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Cheng, Lan, Pohlabeln, Hermann, Wolters, Maike, Ahrens, Wolfgang, Siani, Alfonso, Veidebaum, Toomas, Tornaritis, Michael, Molnár, Dénes, Eiben, Gabriele, Hunsberger, Monica, De Henauw, Stefaan, Moreno, Luis A, and Hebestreit, Antje
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- 2025
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46. How reliable is artificial intelligence in the diagnosis of cholesteatoma on CT images?
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Emilio, Avallone, De Luca, Pietro, Max, Timm, Agnese, Siani, Pasquale, Viola, Massimo, Ralli, Giuseppe, Chiarella, Filippo, Ricciardiello, Antonio, Salzano Francesco, and Alfonso, Scarpa
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- 2025
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47. Safety of an extension of use of oil from Schizochytrium limacinum (strain FCC‐3204) as a novel food pursuant to Regulation (EU) 2015/2283
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EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch‐Ernst, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Harry J. McArdle, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Margarita Aguilera‐Gómez, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Monika Neuhäuser‐Berthold, Morten Poulsen, Miguel Prieto Maradona, Josef Rudolf Schlatter, Alexandros Siskos, Henk vanLoveren, Irene Nuin Garciarena, Emanuela Turla, Silvia Valtueña Martínez, and Helle Katrine Knutsen
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alga ,DHA ,docosahexaenoic acid ,extension of use ,novel food ,safety ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on the safety of an extension of use of oil from Schizochytrium limacinum (strain FCC‐3204) as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The extension of use pertains to the use of the NF as a food ingredient in protein products at a maximum use level of 1 g of docosahexaenoic acid (DHA) in 100 g of product. The Panel considers that the information provided on the composition and the production process is sufficiently described and does not raise safety concerns. S. limacinum was attributed the qualified presumption of safety (QPS) status with the qualification ‘for production purposes only’. Data provided demonstrated the absence of viable cells in the NF. Under the proposed extension of use, the highest intake estimate (at the 95th percentile) of DHA from the NF in protein products is 6.3 mg DHA/kg bw per day for adolescents. The Panel notes that the exposure to DHA from the new intended use of the NF in protein products is very low compared to the exposure to DHA from the already authorised food categories (excluding food supplements). The Panel concludes that the NF (oil from S. limacinum (FCC‐3204)) is safe under the new intended use.
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- 2024
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48. Comparative analysis of the bioaccumulation of bisphenol A in the blood serum and follicular fluid of women living in two areas with different environmental impacts
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Salvatore Raimondo, Maria Luisa Chiusano, Mariacira Gentile, Tommaso Gentile, Felice Cuomo, Raffaella Gentile, Domenico Danza, Laura Siani, Claudia Crescenzo, Mariangela Palmieri, Stefania Iaccarino, Mirella Iaccarino, Adriana Fortunato, Francesca Liguori, Antonio Esposito, Clelia Zullo, Loredana Sosa, Laura Sosa, Ida Ferrara, Marina Piscopo, Tiziana Notari, Raffaele Lacatena, Alberto Gentile, and Luigi Montano
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BPA ,airborne bisphenol ,pollution ,follicular fluid ,land of fires ,environmental health ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
IntroductionBisphenol A (BPA) is a common contaminant widely used in many industrial sectors. Because of its wide use and dispersion, it can be accumulated in living human bodies through both oral assumption and nondietary routes. BPA exhibits hormone-like properties, falling under the class of endocrine disruptors; therefore, it can alter relevant physiological functions. In particular, in women, it can affect folliculogenesis and therefore reproduction, contributing not only to infertility, but also to endometriosis and premature puberty.MethodsWe conducted a multicenter study on 91 women undergoing a first in vitro fertilization (IVF) treatment in the Campania region (Southern Italy). We investigated the presence and concentration of BPA in serum and follicular fluids to assess the effects of airborne BPA contamination. The analysis was conducted on 32 women living in a low environmental impact (LEI) area, from the Sele Valley River and Cilento region, and 59 women living in a high environmental impact (HEI) area, the so-called “Land of Fires”, a highly contaminated territory widely exposed to illegal waste practices.ResultsA higher average BPA content in both blood serum and follicular fluid was revealed in the HEI group when compared with the LEI group. In addition, we revealed higher average BPA content in blood serum than in folliclular fluid in the HEI area, with opposite average content in the two fluids in the LEI zone. In addition, our results also showed a lack of correlation between BPA content in follicular and serum fluids both in the overall population and in the HEI and LEI groups, with peculiar trends in different subsets of women.ConclusionFrom our results, we revealed a heterogeneity in the distribution of BPA content between serum and follicular fluid. Further studies are needed to unravel the bioaccumulation mechanisms of BPA in highly polluted and nonpolluted areas.
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- 2024
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49. Guidance on the scientific requirements for a notification and application for authorisation of traditional foods from third countries in the context of Regulation (EU) 2015/2283
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EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Jacqueline Castenmiller, Stefaan de Henauw, Karl‐heinz Engel, Karen Ildico Hirsch‐Ernst, John Kearney, Helle Katrine Knutsen, Alexandre Maciuk, Inge Mangelsdorf, Harry J. McArdle, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Carmen Peláez, Henk vanLoveren, Wolfgang Gelbmann, Ermolaos Ververis, and Emanuela Turla
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EFSA guidance ,novel foods ,primary production ,safety ,third country ,traditional foods ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract The European Commission requested EFSA to update the scientific guidance for the preparation of notifications for authorisation of traditional foods, previously developed following the adoption of Regulation (EU) 2015/2283 on novel foods. This guidance document provides advice on the scientific information needed to be submitted by applicants when submitting traditional food notifications pursuant to Article 14 and traditional food applications pursuant to Article 16 of Regulation (EU) 2015/2283. The safety of a traditional food should be substantiated by data on its composition, its experience of continued use and its proposed conditions of use. Its normal consumption should not be nutritionally disadvantageous. The applicant should integrate the information on the composition and the experience of continued use and provide a concise overall consideration on how this substantiates the history of safe use of the traditional food and how this relates to the proposed conditions of use for the EU. Potential health hazards identified on the basis of compositional data and/or data from the experience of continued use should be discussed. On the basis of the information provided, EFSA will assess the safety related to the consumption of the traditional food under the proposed conditions of use.
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- 2024
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50. Guidance on the scientific requirements for an application for authorisation of a novel food in the context of Regulation (EU) 2015/2283
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EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Jacqueline Castenmiller, Stefaan de Henauw, Karen Ildico Hirsch‐Ernst, Alexandre Maciuk, Inge Mangelsdorf, Harry J. McArdle, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Margarita Aguilera Gómez, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Monika Neuhäuser‐Berthold, Carmen Peláez, Morten Poulsen, Miguel Prieto Maradona, Josef Rudolf Schlatter, Alexandros Siskos, Henk van Loveren, Reinhard Ackerl, Océane Albert, Domenico Azzollini, Antonio Fernández Dumont, Wolfgang Gelbmann, Andrea Germini, Maria Glymenaki, Georges E. N. Kass, Eirini Kouloura, Marcello Laganaro, Leonard Matijevic, Vânia Mendes, Estefanía Noriega Fernández, Irene Nuin Garciarena, Gabriela Precup, Ruth Roldán Torres, Annamaria Rossi, Emanuela Turla, Silvia Valtueña Martinez, Ermolaos Ververis, and Helle Katrine Knutsen
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authorisation ,EFSA guidance ,food innovation ,food safety ,hazard characterisation ,hazard identification ,Nutrition. Foods and food supply ,TX341-641 ,Chemical technology ,TP1-1185 - Abstract
Abstract The European Commission requested EFSA to update the scientific guidance for the preparation of applications for authorisation of novel foods, previously developed following the adoption of Regulation (EU) 2015/2283 on novel foods. This guidance document provides advice on the scientific information needed to be submitted by the applicant towards demonstrating the safety of the novel food. Requirements pertain to the description of the novel food, production process, compositional data, specifications, proposed uses and use levels and anticipated intake of the novel food. Furthermore, information needed in sections on the history of use of the novel food and/or its source, absorption, distribution, metabolism, excretion, toxicological information, nutritional information and allergenicity is also described. The applicant should integrate and interpret the data presented in the different sections to provide their overall considerations on how the information supports the safety of the novel food under the proposed conditions of use. Where potential health hazards have been identified, they are to be discussed in relation to the anticipated intake of the novel food and the proposed target populations. On the basis of the information provided, EFSA will assess the safety of the novel food under the proposed conditions of use.
- Published
- 2024
- Full Text
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