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Relevance. The creation of new varieties and hybrids of sweet pepper adapted to the conditions of the Astrakhan region will increase yields, product quality and competitiveness. The analysis of the inheritance of valuable traits in F1 hybrids will also expand the base of the pepper gene pool and create new promising varieties and hybrids that meet the requirements of the modern market and consumers. The purpose of the study was to study the collection and breeding material for the creation of F1 sweet pepper hybrids with a combination of new economically valuable ones in the Astrakhan region.Methodology. The work was carried out in the Astrakhan region, Kamyzyaksky district in the VNIIOOB branch of the "PAFSC RAS" according to accepted methods and technologies. During 2021-2023, 82 collection samples and 420 breeding lines were studied, with a total area of 0.42 ha.The objects of research were 4 varieties and 1 line of sweet pepper.Results. In the collection and breeding nurseries, promising samples were selected, according to which hybridization was carried out. When studying the hybrids obtained, four hybrid combinations are of breeding interest: Cuboid red x Sprinter, Sprinter x Gift of Moldova, Sprinter x Flight, Flight x Sprinter. Inheritance was studied according to the characteristics: the type of bush, the shape of the fruit, color in the technical and biological degree of maturity, wall thickness and insemination of fruits. We studied the parental forms and inheritance of sweet pepper traits in F1 hybrids of four crossing combinations. Description and selection of combinations Cube-shaped red × Sprinter and Sprinter × Podarok Moldovan, exceeding the standard in yield by 5.7-7.3 tonnes/ha, which are of interest for further breeding work. It was determined that in the obtained hybrid combinations, the morphological characteristics of plants were inherited mainly by overdomination of the Sprinter variety.Conclusion. The research results can be applied in practice when creating the starting material for future varieties and hybrids of sweet pepper, and the resulting hybrids will complement the range of existing varieties and hybrids of sweet pepper.

The article examines the “Napoleonic” stanza XXXVII from the Seventh Chapter of the novel “Eugene Onegin” in the context of poetics, problematics, and the spiritual ideal of the work. Pushkin’s analogy of the figurative pairs “Napoleon — Moscow” and “Onegin — Tatiana” appears the most important and meaningful. The research demonstrates that mentioning the only historical person in the novel acting in a concrete historical situation is extraordinary for the artistic system of “Eugene Onegin” and largely organizes Pushkin’s hierarchy of meanings. The article reveals the place of the lyrical digression from the novel among Pushkin’s numerous insights into the mystery of Napoleon’s personality. The involvement of historical materials from 1812 helps to disclose the comprehensive poetic formula of “generous fire” from earlier Pushkin’s works. The fire of Moscow and Tatiana’s sacrifice are seen as the realization and victory of Christian life values. Pushkin’s description of the historical event and the final explanation of Onegin and Tatiana reveals a profound unity of the national spiritual code, rejecting the Napoleonic principle of life and eternally triumphant over the world turmoil.

Relevance. Improving zonal agricultural technologies for the cultivation and seed production of vegetable crops is due to the need to increase agroeconomic and technological efficiency, production profitability and competitiveness of domestic products in a market economy and Western sanctions in order to ensure the country's food security and import substitution.Methodology. Improving the elements of zonal agricultural technology for cultivating the new variety of sweet pepper Zarnitsa to increase the productivity and quality of seeds and reduce the costs of its seed production in a seedless culture through the use of micro fertilizers (Ultramag Boron) and plant growth regulators (Zircon R) is the goal of the ongoing research.The objective of the research is to study and evaluate the agroeconomic efficiency of using the Ultramag Bor micro fertilizer and the Zircon, P plant growth regulator and their impact on the dynamics of plant growth and development, ripening time, yield and quality of sweet pepper seeds in the experiment.The practical significance of the research lies in the possibility of widespread use in the real sector of the economy of plant growth regulators and micro fertilizers in non-seedling seed production of sweet pepper to improve productivity, quality and economic indicators of its cultivation in irrigated agriculture in the south of Russia.Results. It was found that sweet pepper plants grown without seedlings using micro fertilizers and plant growth regulators during the fruiting phase had advantages over the control: in plant height by 6.1; 12.2 and 14.5%, the number of side shoots by 20; 36 and 40%, leaf weight by 5.9; 14.2 and 17.5%, average fetal weight by 3.8; 11.7 and 13.5%. The highest yield of sweet pepper in the experiment (33.6 t/ha), which exceeded the control by 3.2 t/ha (10.5%), and the highest content of vitamin C in the fruits (164 mg%), which is 8 mg% higher than in the control were noted in the variant with the combined use of micro fertilizer and plant growth regulator. Sweet pepper seeds in all experimental variants met the standard requirements (germination rate - 93-96%, germination energy - 93-95%). The highest level of profitability (109.3%) was observed in the variant with the combined use of micro fertilizer and plant growth regulator, exceeding the control by

Introduction Transition of care from hospital to primary care has been recognised globally as a high-risk scenario for older patients’ safety by the WHO. Indeed, sub-optimal care transitions are associated with increased mortality, morbidity and adverse events.Improving communication through timely and accurate clinical information transfer has been identified as a key component of optimal care transitions. However, timely and accurate clinical information transfer from hospital to primary care varies across countries and institutions. Information transfer practices are heterogeneous, in some places depending on individual initiative and sometimes not occurring at all.To improve current practices, we will conduct a scoping review to identify the current and suggested practices of information transfer between hospital-based physicians or pharmacists and the primary care team of older patients.Methods and analysis This scoping review will be conducted using Arksey and O’Malley’s methodological framework, augmented by Levac et al and the JBI Manual for Evidence Synthesis, and the findings reported according to the PRISMA extension for Scoping Reviews. We will use a search strategy developed with a specialised librarian to search four databases (MEDLINE, Embase, CINAHL and AgeLine) and reference lists of selected studies. All studies adhering to our iteratively created eligibility criteria outlined by the population, concept and context elements will be included. The data extraction table will also be constructed iteratively with the research team, and results will be presented tabularly and qualitatively.Ethics and dissemination Ethics approval was obtained. We plan to disseminate the results as scientific communication (peer-reviewed journal and presentations) and during a deliberative dialogue workshop with key stakeholders in order to generate recommendations to improve current practices in our own clinical setting, potentially to be adapted and scaled up with our collaborators provincially, nationally and internationally.This protocol has been registered on the Open Science Framework: https://osf.io/eg958.

In this study, health anxiety and optimism were determined as predictors of subjective happiness. A total of 301 individuals, 168 females (55.8%) and 133 males (44.2%) participated in the study carried out based on the correlational model. The research data were collected online due to the pandemic. In the study, Personal Information Form, Health Anxiety Scale, Optimism Scale and Subjective Happiness Scale were used as data collection tools. According to the findings obtained from the study, statistically significant and negative correlations were found between the health anxiety variable and the variables of subjective happiness and optimism. In addition to these results, statistically significant and positive correlations were determined between the optimism variable and subjective happiness variable. Mediation analyses were conducted in the study, and according to the results, it was revealed that optimism had a mediating role in the relationship between health anxiety and subjective happiness. As a result, the indirect effect of health anxiety on subjective happiness was found to be statistically significant. It is believed that the findings of the research will benefit experts who prepare intervention programs for individuals who experience intense anxiety during the pandemic process and who have low levels of subjective happiness.

Primary cutaneous lymphomas (PCLs), especially mycosis fungoides (MF), pose significant diagnostic and therapeutic challenges. This study aims to correlate initial histological features with the disease course and survival in MF patients. A retrospective–prospective cohort study was conducted on 83 patients diagnosed with early-stage MF at the Departments of Dermatovenerology and Pathology, UHC Zagreb, from January 2003 to December 2012. The analyzed histopathological parameters included lichenoid dermal lymphocyte infiltrate, Pautrier microabscesses, and lymphocyte atypia. Patients with more than 30 guardian lymphocytes per 100 keratinocytes exhibited worse overall and progression-free survival. Furthermore, those with over 50% atypical lymphocytes demonstrated a faster progression rate. A dense lichenoid dermal infiltrate and a high count of lymphocyte “keepers” significantly increased the mortality risk within five years of diagnosis. This study did not fully confirm the hypothesis regarding the prognostic value of large Pautrier microabscesses but highlighted the importance of dense lichenoid infiltrates. The study identified new potential histopathological prognostic factors in early-stage MF, suggesting the need for larger studies to confirm these findings. The identification of such predictors could enhance the prognostic stratification and guide more tailored therapeutic approaches for MF patients.

Abstract Lipids are the most abundant but poorly explored components of the human brain. Here, we present a lipidome map of the human brain comprising 75 regions, including 52 neocortical ones. The lipidome composition varies greatly among the brain regions, affecting 93% of the 419 analyzed lipids. These differences reflect the brain’s structural characteristics, such as myelin content (345 lipids) and cell type composition (353 lipids), but also functional traits: functional connectivity (76 lipids) and information processing hierarchy (60 lipids). Combining lipid composition and mRNA expression data further enhances functional connectivity association. Biochemically, lipids linked with structural and functional brain features display distinct lipid class distribution, unsaturation extent, and prevalence of omega-3 and omega-6 fatty acid residues. We verified our conclusions by parallel analysis of three adult macaque brains, targeted analysis of 216 lipids, mass spectrometry imaging, and lipidome assessment of sorted murine neurons.

Relevance. The purpose of the research was to improve the elements of zonal agricultural technology for cultivating a new variety of sweet pepper Zarnitsa, to study the possibility of increasing productivity, reducing production costs during its seed production through the use of a non-seedling method of cultivation in irrigated conditions and the plant growth regulator Zircon, R.Methodology. Experimental studies were carried out on the experimental field of All-Russian Research Institute of Irrigated Vegetable and Melon Growing (Astrakhan region) in 2022-2023. The establishment of the field experiment and the carrying out of records and observations in the experiment were carried out in accordance with generally accepted methods.Results. It was found that with the seedless method of growing sweet pepper, the period from sowing to the start of fruit harvesting was 12 days shorter. Sweet pepper plants in the seedling method during the fruiting phase had advantages: in plant height by 9.3%, in the number of lateral shoots by 21.2%, in leaf weight by 7.0%, in average fruit weight by 6.1%. The highest yield, on average 31.6 t/ha, was obtained using the seedling method; when sowing seeds in the ground, it was 3.8% lower. Replacing the seedling method of cultivation with a non-seedling method contributed to a reduction in production costs by 74.7 thousand rub./ha, production costs by 1.9 thousand rub./t, production profitability by 1.2 times, due to savings in labor resources and working capital for growing and planting seedlings. Replacing the seedling method of cultivation with a non-seedling method helped reduce production costs by 74.7 thousand rub./ha, production costs by 1.9 thousand rubles/t, the profitability of production of sweet pepper products and seeds by 1.2 times, due to savings labor resources, working capital for growing, planting seedlings. A single treatment with the plant growth regulator Zircon, P (30 ml/ha) at the beginning of flowering contributed to a significant increase in plant biometric parameters: height by 12.2%, number of lateral shoots by 30.8%, leaf weight by 14.3%, yield by 2.4 t/ha (7.9%), compared to the control (30.4 t/ha), an increase in sugar content by 0.2%, vitamin C by 4 mg% and seed yield by 9 kg/ha (8.7%). The sowing qualities of sweet pepper seeds in all variants of the experiment met the standard requirements and were – 94-95% in terms of germination and – 92-94% in terms of germination energy. The highest level of profitability of 204.9% was obtained as a result of using a growth regulator; in the option without treatment it was lower by 14.4%.

With the continuous progress of medical technology, traditional medicine bottle identification and management methods have problems such as low efficiency and large errors, and innovative solutions are urgently needed. Due to its high sensitivity and rapid response characteristics, this study aims to develop a robot system for intravenous infusion based on nanophotonics sensing to realize accurate identification, grasping and opening of medicine bottles in a dynamic environment, so as to improve the safety and efficiency of intravenous infusion. In this paper, an intelligent robot system with nanophotonics sensor is designed, which uses nanomaterials to produce high sensitivity sensor, so as to realize the information recognition of medicine bottle labels. The robot arm is set up to grasp and open the medicine bottle automatically through visual recognition system and feedback control algorithm. We conducted several rounds of experiments in a simulated environment to evaluate the recognition rate, grab success rate, and opening speed of the system. The experimental results show that the recognition system based on nano photonic sensor in bottle of accuracy and grab the success rate is higher, open time is greatly shortened, compared with traditional methods, the new system in recognition and operation were showed a significant advantage. The study demonstrates the potential of nanophotonics sensing technology in intravenous infusion robots. By optimizing the process of bottle recognition, grasping and opening, the system not only improves the safety and efficiency of medical operations, but is also expected to play a role in future medical automation. Future work will focus on further perfecting the system integration and optimization algorithm, so as to adapt to more complex clinical environment.

Entrepreneurship is a crucial driver of economic growth, necessitating the development of effective entrepreneurial ecosystems. However, there are significant gaps in the literature regarding the structured assessment of these ecosystems. This study addresses three main research gaps: the lack of structured evaluation methods, the need for a comprehensive analysis of ecosystem challenges from various perspectives, and the identification of critical factors essential for ecosystem growth. To bridge these gaps, the research introduces the Hierarchical Decision Model (HDM) as a universal assessment framework that can be adapted to different cities for creating effective entrepreneurial environments. The research methodology involved formulating perspectives and criteria through literature reviews and expert interviews. These perspectives and criteria were validated by subject matter experts and quantified by other experts to assign relative weights to each. Desirability curves were developed to measure these criteria, scored by experts. The practical applicability of the HDM was demonstrated through a case study of Riyadh, showcasing the model's effectiveness in real-world scenarios. Key findings include the identification and ranking of twenty critical criteria across five main perspectives, along with the development of desirability curves for each criterion. This provides a practical, easy-to-implement evaluation tool for policymakers. The contributions of this research are multifaceted: it introduces HDM to the field of entrepreneurship ecosystem assessment, offers a practical model for ecosystem performance measurement, and presents a framework for policy improvements. Additionally, it highlights the importance of continuous model refinement and the inclusion of diverse case studies for broader validation. Future research should focus on expanding the model to include sub-models for different regions and stages of startups’ development, ensuring its ongoing relevance and applicability. The findings show the most effective factors (perspectives and criteria) in developing entrepreneurial ecosystems and provide a method to measure the level of each criterion without requiring deep knowledge of the methodology, making it easier to implement the model in any ecosystem with any experts. The research offers an explicit case study evaluation of Riyadh's entrepreneurial ecosystem and provides recommendations for improvement areas. This study contributes to the technology management body of knowledge, particularly in the context of entrepreneurship ecosystems, presenting a universal assessment model for measuring ecosystem performance in any city. It creates an evaluation and improvement framework for policymakers to develop entrepreneurial ecosystems in their cities, ensuring continuous relevance and practicality through ongoing refinement and diverse case study applications.

Abstract Objective: to map the scientific literature on the validity of instruments for evaluating the quality of services provided in primary health care for chronic diseases related to systemic arterial hypertension, diabetes mellitus, leprosy and tuberculosis. Method: scoping review, following the Joanna Briggs Institute method and described in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews. 13 databases and gray literature were included. The selection of studies was carried out after removing duplicates and individual and paired evaluation. The data was extracted based on an elaborate script and presented in tables and charts. Results: the analysis of 28 selected studies showed that the majority were from Brazil, followed by China and Malaysia. Almost half of the validated instruments were generic, and the specific ones covered the evaluation of diabetes mellitus and leprosy. The types of validation carried out were content and construct. Conclusion: there is a need to construct specific instruments due to the scarcity of studies on the process of validating instruments for evaluating the quality of services provided by primary health care for chronic diseases.

Hydromorphological degradation is one of the most common stressors to freshwater ecosystems nowadays. Rivers lose riparian vegetation, habitat heterogeneity, natural flow velocity, etc., due to hydromorphological alterations. We analyzed macroinvertebrate communities in a wide range of hydromorphological conditions – from near natural sites to significantly altered water bodies, focusing on Ephemeroptera, Plecoptera, and Trichoptera (EPT). Considering that the EPT group is a quite sensitive and generally stenovalent group, we wanted to examine which of the hydromorphological pressures affects them the most. We also wanted to identify indicator taxa for different levels of degradation: minor, moderate, and severe. We collected samples from 84 karst rivers sites in Croatia. We found 52 taxa of EPT (Ephemeroptera – 21, Plecoptera – 11, Trichoptera – 20). Changes in river morphology proved to be the most important stressor affecting the distribution of the EPT group. Hydrological regulation did not show significance toward the EPT community, possibly due to the karst nature of the rivers studied. The most sensitive EPT taxa were those with the greatest preference for macrophytes and lithal habitats. More tolerant EPT taxa were those with a wide range of habitat preferences and/or taxa that feed on particulate organic matter. HIGHLIGHTS Our research underscores the pivotal role of morphological changes in rivers as the primary stressor impacting EPT communities.; We identify indicator taxa for different levels of hydromorphological degradation.; Focusing on the understudied karst rivers, our research provides unique insights into the complex and heterogeneous habitats of these ecosystems.; Reliable metrics for assessing river health.;

Despite being one of the most common infectious diseases, urinary tract infections (UTIs) still represent a challenge for clinicians to diagnose and treat, especially in the era of growing antibiotic resistance among uropathogenic bacteria. Recent studies investigating the pathophysiology of UTIs have discovered the prominent role of antimicrobial peptides in the urinary tract defense system. Cathelicidin is an evolutionary conserved antimicrobial peptide encoded by one single gene in humans. Except for being stored in neutrophil cytoplasmic granules, cathelicidin is produced by uroepithelial cells rapidly upon contact with a uropathogen, even before leukocytes invade the urinary tract. In addition to its bactericidal effect, cathelicidin acts as a chemoattractant for multiple immune cells and a potent inductor of numerous cytokine synthesis. Such a crucial role in the initial pathogenesis of a UTI makes cathelicidin a potential biomarker for an early UTI diagnosis. Indeed, multiple studies over the last two decades have proved the potential clinical utility of cathelicidin as a UTI diagnostic biomarker. Furthermore, since patients after the resolution of a UTI have been found to express a lower urinary cathelicidin level than healthy controls, decreased cathelicidin levels have been suggested as a risk factor for developing UTI recurrence. Therefore, measuring cathelicidin levels in urine might help in distinguishing patients with a higher risk for a recurrent UTI. Interestingly, except in UTIs, cathelicidin has also been evaluated in other urinary tract diseases and proposed as a biomarker for diagnosing severe vesicoureteral reflux (VUR) and for recognizing renal scar development in patients with VUR. Finally, a prominent role in UTI pathogenesis also makes cathelicidin an attractive therapeutic target for treating UTIs and, lately, different therapeutic agents up-regulating cathelicidin expression have been investigated in this matter. Therefore, the present review aims to summarize the current body of knowledge on the diagnostic, prognostic and therapeutic potential of cathelicidin in urinary tract diseases. For this purpose, three databases (Scopus, Medline and Web of Science) were extensively searched to cover all the published articles. This exhaustive review will update clinicians on the contemporary state of knowledge about the potential clinical utility of cathelicidin in urinary tract diseases and hopefully encourage further research, resulting in improvement in the current management of urinary tract diseases.

The aim of this study was to evaluate the effects of mechanized final irrigation protocols (XPE, XP-Endo Finisher; XPC, XP-Clean; and ECL, Easy Clean) compared to PUI (passive ultrasonic irrigation) on the debris incidence and open dentinal tubules, and their effects on the adhesion interface after 48 h and 6 months. One hundred twenty maxillary central incisors were submitted to chemical–mechanical preparation using a rotary instrument and 2.5% sodium hypochlorite. Specimens were distributed in 4 groups (n = 30) in accordance with the mechanized final irrigation protocol: XPE, XPC, ECL, or PUI. Forty specimens (n = 10/group) were submitted to SEM analysis to evaluate the residue incidence and dentin open tubules. The other specimens were obturated using Bio-C Sealer and submitted to push-out bond strength and adhesive failure mode evaluations in the cervical, middle, and apical thirds after 48 h or 6 months (n = 10/group). Only in the apical third, ECL presented the highest residue incidence and fewer open dentinal tubules when compared to the XPE, XPC, and PUI groups (p < 0.05). In the cervical and middle root thirds, no significant differences were observed regardless of the group evaluated (p > 0.05). After 48 h, ECL resulted in the lowest bond strength only in the apical third (p < 0.05), while the XPE, XPC, and PUI groups remained similar in the cervical and middle thirds (p > 0.05). At 6 months, all groups showed lower bond strength values regardless of the root third evaluated, but ECL showed the lowest bond strength in the apical and middle root thirds when compared to the other groups (p < 0.05). The ECL protocol did not provide adequate residue removal on the apical radicular third and negatively affected the longevity of endodontic obturation using a calcium silicate-based sealer.

The aim of this study is to determine the effect of history teaching supported by dramatization technique on students' success and permanence in history education in comparison with the traditional teaching. In this research, the semi experimental method which was practiced by pretest, post-test and permanence test were used and it was studied on two different student groups. One of them is control group tested with lecture method and the other one is experimental group tested by dramatization technique. Tested group consists of 63 students who studying in classes 10-A and 10-B of a vocational high school of Kirikkale. This study is limited with units of "From Principality to State" in 10th grade students. During this experiment containing retention test were applied to experimental and control groups and the results were analyzed by the program SPSS 16.0. According to the findings obtained, in history lesson: there is a significant difference between the points of success and permanence of the group which is tested by dramatization technique and the group which is tested by teacher centered teaching. In other words, the dramatization technique, which actively involved students in the learning environment, was found to be more effective in the educational success of students and permanence of the information they learned compared to the teacher centered approach on the transfer of historical information to the students.