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1. Clinical features of post-COVID period. Results of an International Register 'Dynamics Analysis of Comorbidities in SARS-CoV-2 Survivors (ACTIV SARS-CoV-2)' (12-month follow-up)

Author: G. P. Arutyunov, E. I Tarlovskaya, A. G. Arutyunov, Yu. N. Belenkov, A. O. Konradi, Yu. M. Lopatin, A. P. Rebrov, S. N. Tereshchenko, A. I. Chesnikova, H. G. Hayrapetyan, A. P. Babin, I. G. Bakulin, N. V. Bakulina, L. A. Balykova, A. S. Blagonravova, M. V. Boldina, M. I. Butomo, A. R. Vaisberg, A. S. Galyavich, V. V. Gomonova, N. Yu. Grigorieva, I. V. Gubareva, I. V. Demko, A. V. Evzerikhina, A. V. Zharkov, A. A. Zateishchikova, U. K. Kamilova, Z. F. Kim, T. Yu. Kuznetsova, A. N. Kulikov, N. V. Lareva, E. V. Makarova, S. V. Malchikova, S. V. Nedogoda, M. M. Petrova, I. G. Pochinka, K. V. Protasov, D. N. Protsenko, D. Yu. Ruzanav, S. A. Sayganov, A. Sh. Sarybaev, N. M. Selezneva, A. B. Sugraliev, I. V. Fomin, O. V. Khlynova, O. Yu. Chizhova, I. I. Shaposhnik, D. A. Sh'ukarev, A. K. Abdrakhmanova, S. A. Avetisian, H. G. Avoyan, K. K. Azarian, G. T. Aimakhanova, D. A. Ayipova, A. Ch. Akunov, M. K. Alieva, A. R. Almukhambedova, A. V. Aparkina, O. R. Aruslanova, E. Yu. Ashina, O. Yu. Badina, O. Yu. Barysheva, T. I. Batluk, A. S. Batchayeva, R. A. Bashkinov, A. M. Bitieva, I. U. Bikhteyev, N. A. Borodulina, M. V. Bragin, V. A. Brazhnik, A. M. Budu, G. A. Bykova, K. R. Vagapova, D. D. Varlamova, N. N. Vezikova, E. A. Verbitskaya, O. E. Vilkova, E. A. Vinnikova, V. V. Vustina, E. A. Gаlova, V. V Genkel, D. B. Giller, E. I. Gorshenina, E. V. Grigorieva, E. U. Gubareva, G. M. Dabylova, A. I. Demchenko, O. Yu. Dolgikh, M. Y. Duyshobayev, D. S. Evdokimov, K. E. Egorova, A. E. Zheldybayeva, N. V. Zarechnova, Yu. D. Zimina, S. U. Ivanova, E. U. Ivanchenko, M. V. Ilina, M. V. Kazakovtseva, E. V. Kazymova, Yu. S. Kalinina, N. A. Kamardina, A. M. Karachenova, I. A. Karetnikov, N. A. Karoli, M. Kh. Karsiev, D. S. Кaskaeva, K. F. Kasymova, Zh. B. Kerimbekova, E. S. Kim, N. V. Kiseleva, D. A. Klimenko, O. V. Kovalishena, S. V. Kozlov, E. V. Kolmakova, T. P. Kolchinskaya, M. I. Koliadich, O. V. Kondriakova, M. P. Konoval, D. U. Konstantinov, E. A. Konstantinova, V. A. Kordukova, E. V. Koroleva, A. U. Kraposhina, T. V. Kryukova, A. S. Kuznetsova, T. U. Kuzmina, K. V. Kuzmichev, Ch. K. Kulchoroeva, T. V. Kuprina, I. M. Kuranova, L. V. Kurenkova, N. U. Kurchugina, N. A. Kushubakova, V. I. Levankova, A. A. Ledyaeva, T. V. Lisun, V. E. Lisyanskaya, N. A. Lyubavina, N. A. Magdeyeva, K. V. Mazalov, V. I. Maiseenko, A. S. Makarova, A. M. Maripov, N. V. Markov, A. A. Marusina, E. S. Melnikov, A. I. Metlinskaya, N. B. Moiseenko, F. N. Muradova, R. G. Muradyan, Sh. N. Musaelian, E. S. Nekaeva, N. M. Nikitina, S. E. Nifontov, E. U. Obolentseva, A. A. Obukhova, B. B. Ogurlieva, A. A. Odegova, Yu. V. Omarova, N. A. Omurzakova, Sh. O. Ospanova, V. A. Pavlova, E. V. Pahomova, L. D. Petrov, S. S. Plastinina, D. A. Platonov, V. A. Pogrebetskaya, D. V. Polyakov, D. S. Polyakov, E. V. Ponomarenko, L. L. Popova, A. A. Potanin, N. A. Prokofeva, J. D. Rabik, N. A. Rakov, A. N. Rakhimov, N. A. Rozanova, I. V. Samus, S. Serikbolkyzy, Ya. A. Sidorkina, A. A. Simonov, V. V. Skachkova, R. D. Skvortcova, D. S. Skuridin, D. V. Solovieva, I. A. Solovieva, I. M. Sukhomlinova, A. G. Sushilova, D. R. Tagayeva, E. P. Tikhonova, D. S. Tokmin, A. A. Tolmacheva, M. S. Torgunakova, K. V. Trenogina, N. A. Trostianetckaia, D. A. Trofimov, M. A. Trubnikova, A. A. Tulichev, A. T. Tursunova, N. D. Ulanova, O. V. Fatenkov, O. V. Fedorishina, T. S. Fil, I. U. Fomina, I. S. Fominova, I. A. Frolova, S. M. Tsvinger, V. V. Tsoma, M. B. Cholponbaeva, T. I. Chudinovskikh, I. V. Shavrin, O. A. Shevchenko, D. R. Shikhaliev, E. A. Shishkina, K. U. Shishkov, S. U. Sherbakov, G. V. Shcherbakova, and E. A. Yausheva
Subjects: covid-19, post-covid period, readmissions, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Aim. To investigate on post-COVID period in patients of the Eurasian region.Material and methods. A total of 9364 consecutively hospitalized patients were included in ACTIV registry. Enrollment of patients began on June 29, 2020, and was completed on March 30, 2021, corresponding to the first and second waves of the pandemic. Demographic, clinical, and laboratory data, computed tomography (CT) results, information about inhospital clinical course and complications of COVID-19 during hospitalization were extracted from electronic health records using a standardized data collection form. The design included follow-up telephone interviews with a standard questionnaire at 3, 6, and 12 months to examine the course of post-COVID period.Results. According to ACTIV register, 63% of patients after COVID-19 had new adverse symptoms or exacerbations of the existing symptoms lasting for up to 1 year. After hospital discharge, 79,8% of patients sought unscheduled medical attention in the first 3 months, 79,1% at 4-6 months, and 64,8% at 7-12 months. Readmission rate was 11,8% in the first 3 months, 10,9% at 4-6 months, and 10,1% at 7-12 months. The most common reasons for unscheduled treatment in the first 3 months were uncontrolled hypertension, decompensated type 2 diabetes, destabilization of coronary artery disease, gastrointestinal disease, AF episodes, exacerbation of asthma and chronic obstructive pulmonary disease, decompensated heart failure (HF). The 12-month mortality of COVID-19 survivors after the discharge was 3,08%. Multivariate analysis showed that independent risk factors for fatal outcome were age (direct correlation), the levels of hemoglobin (inverse correlation), oxygen saturation (inverse correlation), and aspartate aminotransferase (direct correlation), as well as class III-IV HF, prior stroke, cancer, inhospital acute kidney injury. Based on these identified risk factors, a nomogram was constructed to determine the 3-month mortality risk after discharge.Conclusion. Analysis of ACTIV register showed that end of the acute phase of COVID-19 does not imply a complete recovery.
Published: 2023
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2. Lipid profile in hospitalized patients with COVID-19 depending on the outcome of its acute phase: data from the international registry 'Dynamics analysis of comorbidities in SARS-CoV-2 infection survivors'

Author: G. P. Arutyunov, E. I. Tarlovskaya, A. G. Arutyunov, Yu. N. Belenkov, A. O. Konradi, Yu. M. Lopatin, A. P. Rebrov, S. N. Tereshchenko, A. I. Chesnikova, G. G. Airapetyan, A. P. Babin, I. G. Bakulin, N. V. Bakulina, L. A. Balykova, A. S. Blagonravova, M. V. Boldina, M. I. Butomo, A. R. Vaisberg, A. S. Galyavich, V. V. Gomonova, N. Yu. Grigorieva, I. V. Gubareva, I. V. Demko, A. V. Evzerikhina, A. V. Zharkov, A. A. Zateyshchikova, U. K. Kamilova, Z. F. Kim, T. Yu. Kuznetsova, A. N. Kulikov, N. V. Lareva, E. V. Makarova, S. V. Malchikova, S. V. Nedogoda, M. M. Petrova, I. G. Pochinka, K. V. Protasov, D. N. Protsenko, D. Yu. Ruzanov, S. A. Saiganov, A. Sh. Sarybaev, N. M. Selezneva, A. B. Sugraliev, I. V. Fomin, O. V. Khlynova, O. Yu. Chizhova, I. I. Shaposhnik, D. A. Schukarev, A. K. Abdrakhmanova, S. A. Avetisyan, O. G. Avoyan, K. K. Azaryan, G. T. Aimakhanova, D. A. Aiypova, A. Ch. Akunov, M. K. Alieva, A. R. Almukhambedova, A. V. Aparkina, O. R. Aruslanova, E. Yu. Ashina, O. Yu. Badina, O. Yu. Barysheva, T. I. Batluk, A. S. Batchaeva, R. A. Bashkinov, A. M. Bitieva, I. U. Bikhteev, N. A. Borodulina, M. V. Bragin, V. A. Brazhnik, A. M. Budu, G. A. Bykova, K. R. Vagapova, D. D. Varlamova, N. N. Vezikova, E. A. Verbitskaya, O. E. Vilkova, E. A. Vinnikova, V. V. Vustina, E. A. Galova, V. V. Genkel, D. B. Giller, E. I. Gorshenina, E. V. Grigoryeva, E. Yu. Gubareva, G. M. Dabylova, A. I. Demchenko, O. Yu. Dolgikh, M. Y. Duishobaev, D. S. Evdokimov, K. E. Egorova, A. N. Ermilova, A. E. Zheldybaeva, N. V. Zarechnova, Yu. D. Zimina, S. Yu. Ivanova, E. Yu. Ivanchenko, M. V. Ilyina, M. V. Kazakovtseva, E. V. Kazymova, Yu. S. Kalinina, N. A. Kamardina, A. M. Karachenova, I. A. Karetnikov, N. A. Karoli, M. Kh. Karsiev, D. S. Kaskaeva, K. F. Kasymova, J. B. Kerimbekova, E. S. Kim, N. V. Kiseleva, D. A. Klimenko, A. V. Klimova, O. V. Kovalishena, S. V. Kozlov, E. V. Kolmakova, T. P. Kolchinskaya, M. I. Kolyadich, O. V. Kondryakova, M. P. Konoval, D. Yu. Konstantinov, E. A. Konstantinova, V. A. Kordyukova, E. V. Koroleva, A. Yu. Kraposhina, T. V. Kryukova, A. P. Kuznetsova, T. Yu. Kuzmina, K. V. Kuzmichev, Ch. K. Kulchoroeva, T. V. Kuprina, I. M. Kuranova, L. V. Kurenkova, N. Yu. Kurchugina, N. A. Kushubakova, V. I. Levankova, A. A. Ledyaeva, T. V. Lisun, V. E. Lisyanskaya, N. A. Lyubavina, N. A. Magdeeva, K. V. Mazalov, V. I. Mayseenko, A. S. Makarova, A. M. Maripov, N. V. Markov, A. A. Marusina, E. S. Melnikov, A. I. Metlinskaya, N. B. Moiseenko, F. N. Muradova, R. G. Muradyan, Sh. N. Musaelyan, E. S. Nekaeva, N. M. Nikitina, S. E. Nifontov, E. Yu. Obolentseva, A. A. Obukhova, B. B. Ogurlieva, A. A. Odegova, Yu. V. Omarova, N. A. Omurzakova, Sh. O. Ospanova, V. A. Pavlova, E. V. Pakhomova, L. D. Petrov, S. S. Plastinina, D. A. Platonov, V. A. Pogrebetskaya, D. V. Polyakov, D. S. Polyakov, E. V. Ponomarenko, L. L. Popova, A. A. Potanin, N. A. Prokofieva, Yu. D. Rabik, N. A. Rakov, A. N. Rakhimov, N. A. Rozanova, S. Serikbolkyzy, Ya. A. Sidorkina, A. A. Simonov, V. V. Skachkova, R. D. Skvortsova, D. S. Skuridin, D. V. Solovieva, I. A. Solovieva, I. M. Sukhomlinova, A. G. Sushilova, D. R. Tagaeva, Yu. V. Titoikina, E. P. Tikhonova, D. S. Tokmin, A. A. Tolmacheva, M. S. Torgunakova, K. V. Trenogina, N. A. Trostyanetskaya, D. A. Trofimov, M. A. Trubnikova, A. A. Tulichev, A. T. Tursunova, N. D. Ulanova, O. V. Fatenkov, O. V. Fedorishina, T. S. Fil, I. Yu. Fomina, I. S. Fominova, I. A. Frolova, S. M. Tsvinger, V. V. Tsoma, M. B. Cholponbaeva, T. I. Chudinovskikh, I. V. Shavrin, O. A. Shevchenko, D. R. Shikhaliev, E. A. Shishkina, K. Yu Shishkov, S. Yu. Shcherbakov, G. V. Shcherbakova, and E. A. Yausheva
Subjects: covid-19, low density lipoproteins, cholesterol, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Aim. To study the lipid profile in hospitalized patients with coronavirus disease 2019 (COVID-19) depending on the outcome of its acute phase according to the AKTIV international registry.Material and methods. The AKTIV registry included men and women over 18 years of age with a diagnosis of COVID-19, who were treated in a hospital. A total of 9364 patients were included in the registry, of which 623 patients were analyzed for levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C) and triglycerides on days 1-2 of hospitalization. The level of high-density lipoprotein cholesterol (HDL-C) was calculated using the Friedewald equation.Results. We found that a decrease in LDL-C level was significantly associated with an unfavorable prognosis for hospitalized patients with COVID-19. This pattern persisted in both univariate and multivariate analyses. LDL-C levels in the final multivariate model had a significant relationship with the prognosis (an increase in the death risk by 1,7 times with a decrease per 1 mmol/l). In addition, we found that the survival of patients with an indicator level of
Published: 2022
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3. Clinical features of post-COVID-19 period. Results of the international register 'Dynamic analysis of comorbidities in SARS-CoV-2 survivors (AKTIV SARS-CoV-2)'. Data from 6-month follow-up

Author: G. P. Arutyunov, E. I. Tarlovskaya, A. G. Arutyunov, Yu. N. Belenkov, A. O. Konradi, Yu. M. Lopatin, A. P. Rebrov, S. N. Tereshchenko, A. I. Chesnikova, H. G. Hayrapetyan, A. P. Babin, I. G. Bakulin, N. V. Bakulina, L. A. Balykova, A. S. Blagonravova, M. V. Boldina, A. R. Vaisberg, A. S. Galyavich, V. V. Gomonova, N. Yu. Grigorieva, I. V. Gubareva, I. V. Demko, A. V. Evzerikhina, A. V. Zharkov, U. K. Kamilova, Z. F. Kim, T. Yu. Kuznetsova, N. V. Lareva, E. V. Makarova, S. V. Malchikova, S. V. Nedogoda, M. M. Petrova, I. G. Pochinka, K. V. Protasov, D. N. Protsenko, D. Yu. Ruzanau, S. A. Sayganov, A. Sh. Sarybaev, N. M. Selezneva, A. B. Sugraliev, I. V. Fomin, O. V. Khlynova, O. Yu. Chizhova, I. I. Shaposhnik, D. A. Shchukarev, A. K. Abdrahmanova, S. A. Avetisian, H. G. Avoyan, K. K. Azarian, G. T. Aimakhanova, D. A. Ayipova, A. Ch. Akunov, M. K. Alieva, A. V. Aparkina, O. R. Aruslanova, E. Yu. Ashina, O. Yu. Badina, O. Yu. Barisheva, T. I. Batluk, A. S. Batchayeva, R. A. Bashkinov, A. M. Bitieva, I. U. Bikhteyev, N. A. Borodulina, M. V. Bragin, A. M. Budu, G. A. Bykova, K. R. Vagapova, D. D. Varlamova, N. N. Vezikova, E. A. Verbitskaya, O. E. Vilkova, E. A. Vinnikova, V. V. Vustina, E. A. Gаlova, V. V. Genkel, E. I. Gorshenina, E. V. Grigorieva, E. Yu. Gubareva, G. M. Dabylova, I. A. Demchenko, O. Yu. Dolgikh, M. Y. Duyshobayev, D. S. Evdokimov, K. E. Egorova, A. N. Ermilova, A. E. Zheldybayeva, N. V. Zarechnova, Yu. D. Zimina, S. Yu. Ivanova, E. Yu. Ivanchenko, M. V. Ilina, M. V. Kazakovtseva, E. V. Kazymova, Yu. S. Kalinina, N. A. Kamardina, A. M. Karachenova, I. A. Karetnikov, N. A. Karoli, M. K. Karsiev, D. S. Кaskaeva, K. F. Kasymova, Zh. B. Kerimbekova, A. Sh. Kerimova, E. S. Kim, N. V. Kiseleva, D. A. Klimenko, A. V. Klimova, O. V. Kovalishena, E. V. Kolmakova, T. P. Kolchinskaya, M. I. Kolyadich, O. V. Kondriakova, M. P. Konoval, D. Yu. Konstantinov, E. A. Konstantinova, V. A. Kordukova, E. V. Koroleva, A. Yu. Kraposhina, T. V. Kriukova, A. S. Kuznetsova, T. Yu. Kuzmina, K. V. Kuzmichev, Ch. K. Kulchoroeva, T. V. Kuprina, I. M. Kouranova, L. V. Kurenkova, N. Yu. Kurchugina, N. A. Kushubakova, V. I. Levankova, N. A. Lyubavina, N. A. Magdeyeva, K. V. Mazalov, V. I. Majseenko, A. S. Makarova, A. M. Maripov, A. A. Marusina, E. S. Melnikov, N. B. Moiseenko, F. N. Muradova, R. G. Muradyan, Sh. N. Musaelian, A. O. Myshak, E. S. Nekaeva, N. M. Nikitina, B. B. Ogurlieva, A. A. Odegova, Yu. M. Omarova, N. A. Omurzakova, Sh. O. Ospanova, E. V. Pahomova, L. D. Petrov, S. S. Plastinina, V. A. Pogrebetskaya, D. V. Polyakov, D. S. Polyakov, E. V. Ponomarenko, L. L. Popova, N. A. Prokofeva, I. A. Pudova, N. A. Rakov, A. N. Rakhimov, N. A. Rozanova, S. Serikbolkyzy, A. A. Simonov, V. V. Skachkova, D. V. Soloveva, I. A. Soloveva, I. M. Sukhomlinova, A. G. Sushilova, D. R. Tagayeva, Yu. V. Titojkina, E. P. Tikhonova, D. S. Tokmin, A. A. Tolmacheva, M. S. Torgunakova, K. V. Trenogina, N. A. Trostianetckaia, D. A. Trofimov, M. A. Trubnikova, A. A. Tulichev, A. T. Tursunova, N. D. Ulanova, O. V. Fatenkov, O. V. Fedorishina, T. S. Fil, I. Yu. Fomina, I. S. Fominova, I. A. Frolova, S. M. Tsvinger, V. V. Tsoma, M. B. Cholponbaeva, T. I. Chudinovskikh, O. A. Shevchenko, T. V. Sheshina, E. A. Shishkina, K. Yu. Shishkov, S. Yu. Sherbakov, and E. A. Yausheva
Subjects: covid-19, aktiv register, cardiovascular diseases, diabetes, postcovid-19 period, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Aim. To study the clinical course specifics of coronavirus disease 2019 (COVID-19) and comorbid conditions in COVID-19 survivors 3, 6, 12 months after recovery in the Eurasian region according to the AKTIV register. Material and methods.The AKTIV register was created at the initiative of the Eurasian Association of Therapists. The AKTIV register is divided into 2 parts: AKTIV 1 and AKTIV 2. The AKTIV 1 register currently includes 6300 patients, while in AKTIV 2 — 2770. Patients diagnosed with COVID-19 receiving in- and outpatient treatment have been anonymously included on the registry. The following 7 countries participated in the register: Russian Federation, Republic of Armenia, Republic of Belarus, Republic of Kazakhstan, Kyrgyz Republic, Republic of Moldova, Republic of Uzbekistan. This closed multicenter register with two nonoverlapping branches (in- and outpatient branch) provides 6 visits: 3 in-person visits during the acute period and 3 telephone calls after 3, 6, 12 months. Subject recruitment lasted from June 29, 2020 to October 29, 2020. Register will end on October 29, 2022. A total of 9 fragmentary analyzes of the registry data are planned. This fragment of the study presents the results of the post-hospitalization period in COVID-19 survivors after 3 and 6 months. Results. According to the AKTIV register, patients after COVID-19 are characterized by long-term persistent symptoms and frequent seeking for unscheduled medical care, including rehospitalizations. The most common causes of unplanned medical care are uncontrolled hypertension (HTN) and chronic coronary artery disease (CAD) and/or decompensated type 2 diabetes (T2D). During 3- and 6-month follow-up after hospitalization, 5,6% and 6,4% of patients were diagnosed with other diseases, which were more often presented by HTN, T2D, and CAD. The mortality rate of patients in the post-hospitalization period was 1,9% in the first 3 months and 0,2% for 4-6 months. The highest mortality rate was observed in the first 3 months in the group of patients with class II-IV heart failure, as well as in patients with cardiovascular diseases and cancer. In the pattern of death causes in the post-hospitalization period, following cardiovascular causes prevailed (31,8%): acute coronary syndrome, stroke, acute heart failure. Conclusion. According to the AKTIV register, the health status of patients after COVID-19 in a serious challenge for healthcare system, which requires planning adequate health system capacity to provide care to patients with COVID-19 in both acute and post-hospitalization period.
Published: 2021
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4. International register 'Dynamics analysis of comorbidities in SARS-CoV-2 survivors' (AKTIV SARS-CoV-2): analysis of predictors of short-term adverse outcomes in COVID-19

Author: G. P. Arutyunov, E. I. Tarlovskaya, A. G. Arutyunov, Y. N. Belenkov, A. O. Konradi, Y. M. Lopatin, A. P. Rebrov, S. N. Tereshchenko, A. I. Chesnikova, H. G. Hayrapetyan, A. P. Babin, I. G. Bakulin, N. V. Bakulina, L. A. Balykova, A. S. Blagonravova, M. V. Boldina, A. R. Vaisberg, A. S. Galyavich, V. V. Gomonova, N. U. Grigorieva, I. V. Gubareva, I. V. Demko, A. V. Evzerikhina, A. V. Zharkov, U. K. Kamilova, Z. F. Kim, T. Yu. Kuznetsova, N. V. Lareva, E. V. Makarova, S. V. Malchikova, S. V. Nedogoda, M. M. Petrova, I. G. Pochinka, K. V. Protasov, D. N. Protsenko, D. Yu. Ruzanov, S. A. Sayganov, A. Sh. Sarybaev, N. M. Selezneva, A. B. Sugraliev, I. V. Fomin, O. V. Khlynova, O. Yu. Chizhova, I. I. Shaposhnik, D. A. Schukarev, A. K. Abdrahmanova, S. A. Avetisian, H. G. Avoyan, K. K. Azarian, G. T. Aimakhanova, D. A. Ayipova, A. Ch. Akunov, M. K. Alieva, A. V. Aparkina, O. R. Aruslanova, E. Yu. Ashina, O. Y. Badina, O. Yu. Barisheva, A. S. Batchayeva, I. U. Bikhteyev, N. A. Borodulina, M. V. Bragin, A. M. Budu, L. A. Burygina, G. A. Bykova, D. D. Varlamova, N. N. Vezikova, E. A. Verbitskaya, O. E. Vilkova, E. A. Vinnikova, V. V. Vustina, E. A. Gаlova, V. V. Genkel, E. I. Gorshenina, R. V. Gostishev, E. V. Grigorieva, E. Yu. Gubareva, G. M. Dabylova, A. I. Demchenko, O. Yu. Dolgikh, I. A. Duvanov, M. Y. Duyshobayev, D. S. Evdokimov, K. E. Egorova, A. N. Ermilova, A. E. Zheldybayeva, N. V. Zarechnova, S. Yu. Ivanova, E. Yu. Ivanchenko, M. V. Ilina, M. V. Kazakovtseva, E. V. Kazymova, Yu. S. Kalinina, N. A. Kamardina, A. M. Karachenova, I. A. Karetnikov, N. A. Karoli, O. V. Karpov, M. Kh. Karsiev, D. S. Kaskaeva, K. F. Kasymova, Zh. B. Kerimbekova, A. Sh. Kerimova, E. S. Kim, N. V. Kiseleva, D. A. Klimenko, A. V. Klimova, O. V. Kovalishena, E. V. Kolmakova, T. P. Kolchinskaya, M. I. Kolyadich, O. V. Kondriakova, M. P. Konoval, D. Yu. Konstantinov, E. A. Konstantinova, V. A. Kordukova, E. V. Koroleva, A. Yu. Kraposhina, T. V. Kriukova, A. S. Kuznetsova, T. Y. Kuzmina, K. V. Kuzmichev, Ch. K. Kulchoroeva, T. V. Kuprina, I. V. Kouranova, L. V. Kurenkova, N. Yu. Kurchugina, N. A. Kushubakova, V. I. Levankova, M. E. Levin, N. A. Lyubavina, N. A. Magdeyeva, K. V. Mazalov, V. I. Majseenko, A. S. Makarova, A. M. Maripov, A. A. Marusina, E. S. Melnikov, N. B. Moiseenko, F. N. Muradova, R. G. Muradyan, Sh. N. Musaelian, N. M. Nikitina, B. B. Ogurlieva, A. A. Odegova, Yu. M. Omarova, N. A. Omurzakova, Sh. O. Ospanova, E. V. Pahomova, L. D. Petrov, S. S. Plastinina, V. A. Pogrebetskaya, D. S. Polyakov, E. V. Ponomarenko, L. L. Popova, N. A. Prokofeva, I. A. Pudova, N. A. Rakov, A. N. Rakhimov, N. A. Rozanova, S. Serikbolkyzy, A. A. Simonov, V. V. Skachkova, L. A. Smirnova, D. V. Soloveva, I. A. Soloveva, F. M. Sokhova, A. K. Subbotin, I. M. Sukhomlinova, A. G. Sushilova, D. R. Tagayeva, Yu. V. Titojkina, E. P. Tikhonova, D. S. Tokmin, M. S. Torgunakova, K. V. Trenogina, N. A. Trostianetckaia, D. A. Trofimov, A. A. Tulichev, D. I. Tupitsin, A. T. Tursunova, N. D. Ulanova, O. V. Fatenkov, O. V. Fedorishina, T. S. Fil, I. Yu. Fomina, I. S. Fominova, I. A. Frolova, S. M. Tsvinger, V. V. Tsoma, M. B. Cholponbaeva, T. I. Chudinovskikh, L. D. Shakhgildyan, O. A. Shevchenko, T. V. Sheshina, E. A. Shishkina, K. Yu. Shishkov, S. Y. Sherbakov, and E. A. Yausheva
Subjects: aktiv register, covid-19, multimorbidity, mortality predictors, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: The international AKTIV register presents a detailed description of out- and inpatients with COVID-19 in the Eurasian region. It was found that hospitalized patients had more comorbidities. In addition, these patients were older and there were more men than among outpatients. Among the traditional risk factors, obesity and hypertension had a significant negative effect on prognosis, which was more significant for patients 60 years of age and older. Among comorbidities, CVDs had the maximum negative effect on prognosis, and this effect was more significant for patients 60 years of age and older. Among other comorbidities, type 2 and 1 diabetes, chronic kidney disease, chronic obstructive pulmonary disease, cancer and anemia had a negative impact on the prognosis. This effect was also more significant (with the exception of type 1 diabetes) for patients 60 years and older. The death risk in patients with COVID-19 depended on the severity and type of multimorbidity. Clusters of diseases typical for deceased patients were identified and their impact on prognosis was determined. The most unfavorable was a cluster of 4 diseases, including hypertension, coronary artery disease, heart failure, and diabetes mellitus. The data obtained should be taken into account when planning measures for prevention (vaccination priority groups), treatment and rehabilitation of COVID-19 survivors.
Published: 2021
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5. International register 'Dynamics analysis of comorbidities in SARS-CoV-2 survivors' (AKTIV) and the register 'Analysis of hospitalizations of comorbid patients infected during the second wave of SARS-CoV-2 outbreak' (AKTIV 2)

Author: G. P. Arutyunov, E. I. Tarlovskaya, A. G. Arutyunov, Y. N. Belenkov, A. O. Konradi, Y. M. Lopatin, A. P. Rebrov, S. N. Tereshchenko, A. I. Chesnikova, H. G. Hayrapetyan, A. P. Babin, I. G. Bakulin, N. V. Bakulina, l. A. Balykova, A. S. Blagonravova, M. V. Boldina, A. R. Vaisberg, A. S. Galyavich, V. V. Gomonova, N. U. Grigorieva, I. V. Gubareva, I. V. Demko, A. V. Evzerikhina, A. V. Zharkov, U. K. Kamilova, Z. F. Kim, T. Yu. Kuznetsova, N. V. Lareva, E. V. Makarova, S. V. Malchikova, S. V. Nedogoda, M. M. Petrova, I. G. Pochinka, K. V. Protasov, D. N. Protsenko, D. Yu. Ruzanov, S. A. Sayganov, A. Sh. Sarybaev, N. M. Selezneva, A. B. Sugraliev, I. V. Fomin, O. V. Khlynova, O. Yu. Chizhova, I. I. Shaposhnik, D. A. Sсhukarev, A. K. Abdrahmanova, S. A. Avetisian, H. G. Avoyan, K. K. Azarian, G. T. Aimakhanova, D. A. Ayipova, A. Ch. Akunov, M. K. Alieva, A. V. Aparkina, O. R. Aruslanova, E. Yu. Ashina, O. Y. Badina, O. Yu. Barisheva, A. S. Batchayeva, A. M. Bitieva, I. U. Bikhteyev, N. A. Borodulina, M. V. Bragin, A. M. Budu, L. A. Burygina, G. A. Bykova, D. D. Varlamova, N. N. Vezikova, E. A. Verbitskaya, O. E. Vilkova, E. A. Vinnikova, V. V. Vustina, E. A. Gаlova, V. V. Genkel, E. I. Gorshenina, E. V. Grigorieva, E. Yu. Gubareva, G. M. Dabylova, A. I. Demchenko, O. Yu. Dolgikh, I. A. Duvanov, M. Y. Duyshobayev, D. S. Evdokimov, K. E. Egorova, A. N. Ermilova, A. E. Zheldybayeva, N. V. Zarechnova, S. Yu. Ivanova, E. Yu. Ivanchenko, M. V. Ilina, M. V. Kazakovtseva, E. V. Kazymova, Yu. S. Kalinina, N. A. Kamardina, A. M. Karachenova, I. A. Karetnikov, N. A. Karoli, O. V. Karpov, M. Kh. Karsiev, D. S. Кaskaeva, K. F. Kasymova, Zh. B. Kerimbekova, A. Sh. Kerimova, E. S. Kim, N. V. Kiseleva, D. A. Klimenko, A. V. Klimova, O. V. Kovalishena, E. V. Kolmakova, T. P. Kolchinskaya, M. I. Kolyadich, O. V. Kondriakova, M. P. Konoval, D. Yu. Konstantinov, E. A. Konstantinova, V. A. Kordukova, E. V. Koroleva, A. Yu. Kraposhina, T. V. Kriukova, A. S. Kuznetsova, T. Y. Kuzmina, K. V. Kuzmichev, Ch. K. Kulchoroeva, T. V. Kuprina, I. M. Kouranova, L. V. Kurenkova, N. Yu. Kurchugina, N. A. Kushubakova, V. I. Levankova, M. E. Levin, N. A. Lyubavina, N. A. Magdeyeva, K. V. Mazalov, V. I. Majseenko, A. S. Makarova, A. M. Maripov, A. A. Marusina, E. S. Melnikov, N. B. Moiseenko, F. N. Muradova, R. G. Muradyan, Sh. N. Musaelian, N. M. Nikitina, B. B. Ogurlieva, A. A. Odegova, Yu. M. Omarova, N. A. Omurzakova, Sh. O. Ospanova, E. V. Pahomova, L. D. Petrov, S. S. Plastinina, V. A. Pogrebetskaya, D. S. Polyakov, E. V. Ponomarenko, L. L. Popova, N. A. Prokofeva, I. A. Pudova, N. A. Rakov, A. N. Rakhimov, N. A. Rozanova, S. Serikbolkyzy, A. A. Simonov, V. V. Skachkova, L. A. Smirnova, D. V. Soloveva, I. A. Soloveva, F. M. Sokhova, A. K. Subbotin, I. M. Sukhomlinova, A. G. Sushilova, D. R. Tagayeva, Yu. V. Titojkina, E. P. Tikhonova, D. S. Tokmin, M. S. Torgunakova, K. V. Trenogina, N. A. Trostianetckaia, D. A. Trofimov, A. A. Tulichev, D. I. Tupitsin, A. T. Tursunova, A. A. Tiurin, N. D. Ulanova, O. V. Fatenkov, O. V. Fedorishina, T. S. Fil, I. Yu. Fomina, I. S. Fominova, I. A. Frolova, S. M. Tsvinger, V. V. Tsoma, M. B. Cholponbaeva, T. I. Chudinovskikh, L. D. Shakhgildyan, O. A. Shevchenko, T. V. Sheshina, E. A. Shishkina, K. Yu. Shishkov, S. Y. Sherbakov, and E. A. Yausheva
Subjects: sars-cov-2, registry, covid-19, comorbidity, risk, multimorbidity, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: The organizer of the registers “Dynamics analysis of comorbidities in SARSCoV-2 survivors” (AKTIV) and “Analysis of hospitalizations of comorbid patients infected during the second wave of SARS-CoV-2 outbreak” (AKTIV 2) is the Eurasian Association of Therapists (EAT). Currently, there are no clinical registries in the Eurasian region designed to collect and analyze information on long-term outcomes of COVID-19 survivors with comorbid conditions. The aim of the register is to assess the impact of a novel coronavirus infection on long-term course of chronic non-communicable diseases 3, 6, 12 months after recovery, as well as to obtain information on the effect of comorbidity on the severity of COVID-19. Analysis of hospitalized patients of a possible second wave is planned for register “AKTIV 2”. To achieve this goal, the register will include men and women over 18 years of age diagnosed with COVID-19 who are treated in a hospital or in outpatient basis. The register includes 25 centers in 5 federal districts of the Russian Federation, centers in the Republic of Armenia, the Republic of Kazakhstan, the Republic of Kyrgyzstan, the Republic of Belarus, the Republic of Moldova, and the Republic of Uzbekistan. The estimated capacity of the register is 5400 patients.
Published: 2021
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6. International register 'Dynamics analysis of comorbidities in SARS-CoV-2 survivors' (AKTIV SARS-CoV-2): analysis of 1,000 patients

Author: G. P. Arutyunov, E. I. Tarlovskaya, A. G. Arutyunov, Y. N. Belenkov, A. O. Konradi, Y. M. Lopatin, S. N. Tereshchenko, A. P. Rebrov, A. I. Chesnikova, I. V. Fomin, N. V. Grigorieva, M. V. Boldina, A. R. Vaisberg, A. S. Blagonravova, E. V. Makarova, I. I. Shaposhnik, T. Yu. Kuznetsova, S. V. Malchikova, D. N. Protsenko, A. V. Evzerikhina, M. M. Petrova, I. V. Demko, D. V. Saphonov, H. G. Hayrapetyan, A. S. Galyavich, Z. F. Kim, A. B. Sugraliev, S. V. Nedogoda, V. V. Tsoma, S. A. Sayganov, V. V. Gomonova, I. V. Gubareva, A. Sh. Sarybaev, E. V. Koroleva, O. E. Vilkova, I. Y. Fomina, I. A. Pudova, D. V. Soloveva, N. V. Kiseleva, N. V. Zelyaeva, I. M. Kouranova, V. A. Pogrebetskaya, F. N. Muradova, O. Y. Badina, O. V. Kovalishena, E. A. Galova, S. S. Plastinina, N. A. Lyubavina, N. N. Vezikova, V. I. Levankova, S. Yu. Ivanova, A. N. Ermilova, R. G. Muradyan, R. V. Gostishev, E. P. Tikhonova, T. Y. Kuzmina, I. A. Soloveva, A. Yu. Kraposhina, M. I. Kolyadich, T. P. Kolchinskaya, V. V. Genkel, A. S. Kuznetsova, M. V. Kazakovtseva, A. A. Odegova, T. I. Chudinovskikh, S. V. Baramzina, N. A. Rozanova, A. Sh. Kerimova, N. A. Krivosheina, S. Y. Chukhlova, A. A. Levchenko, H. G. Avoyan, K. K. Azarian, Sh. N. Musaelian, S. A. Avetisian, M. E. Levin, O. V. Karpov, F. M. Sokhova, L. A. Burygina, T. V. Sheshina, A. A. Tiurin, O. Yu. Dolgikh, E. V. Kazymova, D. Yu. Konstantinov, O. A. Chumakova, O. V. Kondriakova, K. Yu. Shishkov, T. S. Fil, N. A. Prokofeva, M. P. Konoval, A. A. Simonov, A. M. Bitieva, N. A. Trostianetckaia, M. B. Cholponbaeva, Zh. B. Kerimbekova, M. Y. Duyshobayev, A. Ch. Akunov, N. A. Kushubakova, E. S. Melnikov, E. S. Kim, S. Y. Sherbakov, D. A. Trofimov, D. S. Evdokimov, D. A. Ayipova, I. A. Duvanov, A. K. Abdrahmanova, G. T. Aimakhanova, Sh. O. Ospanova, G. M. Dabylova, A. T. Tursunova, D. S. Xaskaeva, A. A. Tulichev, E. Yu. Ashina, V. A. Kordukova, O. Yu. Barisheva, K. E. Egorova, D. D. Varlamova, T. V. Kuprina, E. V. Pahomova, N. Yu. Kurchugina, I. A. Frolova, K. V. Mazalov, A. K. Subbotin, N. A. Kamardina, N. V. Zarechnova, E. M. Mamutova, L. A. Smirnova, A. V. Klimova, L. D. Shakhgildyan, D. S. Tokmin, D. I. Tupitsin, T. V. Kriukova, N. A. Rakov, and D. S. Polyakov
Subjects: aktiv register, sars-cov-2, covid-19, multimorbidity, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: COVID-19 is a severe infection with high mortality. The concept of the disease has been shaped to a greater extent on the basis of large registers from the USA, Spain, Italy, and China. However, there is no information on the disease characteristics in Caucasian patients.Therefore, we created an international register with the estimated capacity of 5,000 patients — Dynamics Analysis of Comorbidities in SARS-CoV-2 Survivors (AKTIV SARS-CoV-2), which brought together professionals from the Russian Federation, Republic of Armenia, Republic of Kazakhstan, and Kyrgyz Republic. The article presents the first analysis of the register involving 1,003 patients. It was shown that the most significant difference of the Caucasian population was the higher effect of multimorbidity on the mortality risk vs other registers. More pronounced effect on mortality of such diseases as diabetes, obesity, hypertension, chronic kidney disease, and age over 60 years was also revealed.
Published: 2020
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7. SELECTION OF THE OPTIMAL ANTIHYPERTENSION TREATMENT IN PATIENTS WITH CHRONIC HEART FAILURE WITH THE SIGNS OF CHRONIC KIDNEY DISEASE

Author: N. Yu Borovkova, Т. Е. Kuznetsova, N. N. Borovkov, A. A. Tulichev, and A. S. Ilyina
Subjects: хроническая сердечная недостаточность, хроническая болезнь почек, артериальная гипертензия, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Aim. To evaluate the effectiveness of fixed combination of perindopril arginine and amlodipine besilate (Prestans®, Les Laboratoires Servier) in optimal treatment scheme selection of arterial hypertension (AH) in patients with chronic heart failure (CHF) having the signs of chronic kidney disease (CKD).Material and methods. Totally, 118 patients studied, with essential AH, with CHF. In 53 (44,9%) of those, thre were signs of CKD. The latter presented with a decreased glomerular filtration rate (GFR) and increased cystatin C in the blood plasma (1,4+0,3 mg/L). As the treatment, they were prescribed the fixed combination of perindopril arginine and amlodipine besilate—5/5, 5/10, 10/10 mg. The assessment of treatment was done in 2 months follow-up.Results. During treatment there was significant decrease of office systolic and diastolic blood pressure (BP). Target BP was reached in 82,6% cases. The mean daily values of systolic and diastolic BP load became lower. During the treatment, there was improvement of clinical condition by functional class of CHF. The score by CAS decreased from 6,2+1,1 to 4,2+1,3 (р
Published: 2016
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8. 16S rRNA gene sequencing data of the upper respiratory tract microbiome in the SARS-CoV-2 infected patients

Author: Julia Galeeva, Vladislav Babenko, Ramiz Bakhtyev, Vladimir Baklaushev, Larisa Balykova, Pavel Bashkirov, Julia Bespyatykh, Anna Blagonravova, Daria Boldyreva, Dmitry Fedorov, Ilshat Gafurov, Raushaniya Gaifullina, Elena Galova, Alina Gospodaryk, Elena Ilina, Konstantin Ivanov, Daria Kharlampieva, Polina Khromova, Ksenia Klimina, Konstantin Kolontarev, Nadezhda Kolyshkina, Andrey Koritsky, Vyacheslav Kuropatkin, Vasily Lazarev, Alexander Manolov, Valentin Manuvera, Daria Matyushkina, Maxim Morozov, Ekaterina Moskaleva, Varvara Musarova, Oleg Ogarkov, Elizaveta Orlova, Alexander Pavlenko, Alla Petrova, Natalia Pozhenko, Dmitry Pushkar, Alexander Rumyantsev, Sergey Rumyantsev, Vladimir Rumyantsev, Lyubov Rychkova, Alexander Samoilov, Irina Shirokova, Vyacheslav Sinkov, Svetlana Solovieva, Elizaveta Starikova, Polina Tikhonova, Galina Trifonova, Alexander Troitsky, Alexander Tulichev, Yuri Udalov, Anna Varizhuk, Alexander Vasiliev, Vladimir Veselovsky, Rinat Vereshchagin, Alexey Volnukhin, Gaukhar Yusubalieva, and Vadim Govorun
Subjects: SARS-CoV-2, Microbiome, 16S, Upper respiratory tract, Computer applications to medicine. Medical informatics, R858-859.7, Science (General), Q1-390
Abstract: The SARS-CoV-2 pandemic is a big challenge for humanity. The COVID-19 severity differs significantly from patient to patient, and it is important to study the factors protecting from severe forms of the disease. Respiratory microbiota may influence the patient's susceptibility to infection and disease severity due to its ability to modulate the immune system response of the host organism.This data article describes the microbiome dataset from the upper respiratory tract of SARS-CoV-2 positive patients from Russia. This dataset reports the microbial community profile of 335 human nasopharyngeal swabs collected between 2020-05 and 2021-03 during the first and the second epidemic waves. Samples were collected from both inpatients and outpatients in 4 cities of the Russian Federation (Moscow, Kazan, Irkutsk, Nizhny Novgorod) and sequenced using the 16S rRNA gene amplicon sequencing of V3-V4 region. Data contains information about the patient such as age, sex, hospitalization status, percent of damaged lung tissue, oxygen saturation (SpO2), respiratory rate, need for supplemental oxygen, chest computer tomography severity score, SARS-CoV-2 lineage, and also information about smoking and comorbidities.The amplicon sequencing data were deposited at NCBI SRA as BioProject PRJNA751478.
Published: 2022
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9. Features of postural control of elderly patients with osteoporosis: Overview

Author: Zverev, Yuriy P., primary, Tulichev, Alexander A., additional, Builova, Tatyana V., additional, Iosko, Natalya V., additional, Ignatieva, Maria O., additional, and Bormotkina, Natalia A., additional
Published: 2023
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10. The impact of BMI on the course of the acute SARS-COV-2 infection and the risks that emerge during the first year after the hospital discharge. Subanalysis evidence of the AKTIV and AKTIV 2 registries

Author: A. G. Arutyunov, E. I. Tarlovskaya, G. R. Galstyan, T. I. Batluk, R. A. Bashkinov, G. P. Arutyunov, Yu. N. Belenkov, A. O. Konradi, Yu. M. Lopatin, A. P. Rebrov, S. N. Tereshchenko, A. I. Chesnikova, H. G. Hayrapetyan, A. P. Babin, I. G. Bakulin, N. V. Bakulina, L. A. Balykova, A. S. Blagonravova, M. V. Boldina, M. I. Butomo, A. R. Vaisberg, A. S. Galyavich, V. V. Gomonova, N. Yu. Grigoryeva, I. V. Gubareva, I. V. Demko, A. V. Evzerikhina, A. V. Zharkov, A. A. Zateishchikova, U. K. Kamilova, Z. F. Kim, T. Yu. Kuznetsova, A. N. Kulikov, N. V. Lareva, E. V. Makarova, S. V. Malchikova, S. V. Nedogoda, M. M. Petrova, I. G. Pochinka, K. V. Protasov, D. N. Protsenko, D. Yu. Ruzanov, S. A. Saiganov, A. Sh. Sarybaev, N. M. Selezneva, A. B. Sugraliev, I. V. Fomin, O. V. Khlynova, O. Yu. Chizhova, I. I. Shaposhnik, D. A. Schukarev, A. K. Abdrakhmanova, S. A. Avetisyan, H. G. Avoyan, K. K. Azaryan, G. T. Aimakhanova, D. A. Ayypova, A. Ch. Akunov, M. K. Alieva, A. R. Almukhambedova, A. V. Aparkina, O. R. Aruslanova, E. Yu. Ashina, O. Yu. Badina, O. Yu. Barysheva, A. S. Batchaeva, A. M. Bitieva, I. U. Bikhteev, N. A. Borodulina, M. V. Bragin, V. A. Brazhnik, A. M. Budu, G. A. Bykova, K. R. Vagapova, D. D. Varlamova, N. N. Vezikova, E. A. Verbitskaya, O. E. Vilkova, E. A. Vinnikova, V. V. Vustina, E. A. Galova, V. V. Genkel, D. B. Giller, E. I. Gorshenina, E. V. Grigoryeva, E. Yu. Gubareva, G. M. Dabylova, A. I. Demchenko, O. Yu. Dolgikh, M. Y. Duishobaev, D. S. Evdokimov, K. E. Egorova, A. N. Ermilova, A. E. Zheldybaeva, N. V. Zarechnova, Yu. D. Zimina, S. Yu. Ivanova, E. Yu. Ivanchenko, M. V. Ilina, M. V. Kazakovtseva, E. V. Kazymova, Yu. S. Kalinina, N. A. Kamardina, A. M. Karachenova, I. A. Karetnikov, N. A. Karoli, M. Kh. Karsiev, D. S. Kaskaeva, K. F. Kasymova, Zh. B. Kerimbekova, E. S. Kim, N. V. Kiseleva, D. A. Klimenko, A. V. Klimova, O. V. Kovalishena, S. V. Kozlov, E. V. Kolmakova, T. P. Kolchinskaya, M. I. Kolyadich, O. V. Kondryakova, M. P. Konoval, D. Yu. Konstantinov, E. A. Konstantinova, V. A. Kordyukova, E. V. Koroleva, A. Yu. Kraposhina, T. V. Kryukova, A. S. Kuznetsova, T. Yu. Kuzmina, K. V. Kuzmichev, Ch. K. Kulchoroeva, T. V. Kuprina, I. M. Kuranova, L. V. Kurenkova, N. Yu. Kurchugina, N. A. Kushubakova, V. I. Levankova, A. A. Ledyaeva, T. V. Lisun, V. E. Lisyanskaya, N. A. Lyubavina, N. A. Magdeeva, K. V. Mazalov, V. I. Mayseenko, A. S. Makarova, A. M. Maripov, N. V. Markov, A. A. Marusina, E. S. Melnikov, A. I. Metlinskaya, N. B. Moiseenko, F. N. Muradova, R. G. Muradyan, Sh. N. Musaelyan, E. S. Nekaeva, N. M. Nikitina, S. E. Nifontov, E. Yu. Obolentseva, A. A. Obukhova, B. B. Ogurlieva, A. A. Odegova, Yu. V. Omarova, N. A. Omurzakova, Sh. O. Ospanova, V. A. Pavlova, E. V. Pakhomova, L. D. Petrov, S. S. Plastinina, D. A. Platonov, V. A. Pogrebetskaya, D. V. Polyakov, D. S. Polyakov, E. V. Ponomarenko, L. L. Popova, A. A. Potanin, N. A. Prokofieva, Yu. D. Rabik, N. A. Rakov, A. N. Rakhimov, N. A. Rozanova, I. V. Samus, S. Serikbolkyzy, Ya. A. Sidorkina, A. A. Simonov, V. V. Skachkova, R. D. Skvortsova, D. S. Skuridin, D. V. Solovieva, I. A. Solovieva, I. M. Sukhomlinova, A. G. Sushilova, D. R. Tagaeva, Yu. V. Titoykina, E. P. Tikhonova, D. S. Tokmin, A. A. Tolmacheva, M. S. Torgunakova, K. V. Trenogina, N. A. Trostyanetskaya, D. A. Trofimov, M. A. Trubnikova, A. A. Tulichev, A. T. Tursunova, N. D. Ulanova, O. V. Fatenkov, O. V. Fedorishina, T. S. Fil, I. Yu. Fomina, I. S. Fominova, I. A. Frolova, S. M. Tsvinger, V. V. Tsoma, M. B. Cholponbaeva, T. I. Chudinovskikh, I. V. Shavrin, O. A. Shevchenko, D. R. Shikhaliev, E. A. Shishkina, K. Yu. Shishkov, S. Yu. Shcherbakov, G. V. Shcherbakova, and E. A. Yausheva
Subjects: Endocrinology, Diabetes and Metabolism
Abstract: BACKGROUND. There is enough evidence of the negative impact of excess weight on the formation and progression of res piratory pathology. Given the continuing SARS-CoV-2 pandemic, it is relevant to determine the relationship between body mass index (BMI) and the clinical features of the novel coronavirus infection (NCI).AIM. To study the effect of BMI on the course of the acute SARS-COV-2 infection and the post-covid period.MATERIALS AND METHODS. AKTIV and AKTIV 2 are multicenter non-interventional real-world registers. The АКТИВ registry (n=6396) includes non-overlapping outpatient and inpatient arms with 6 visits in each. The АКТИВ 2 registry (n=2968) collected the data of hospitalized patients and included 3 visits. All subjects were divided into 3 groups: not overweight (n=2139), overweight (n=2931) and obese (n=2666).RESULTS. A higher BMI was significantly associated with a more severe course of the infection in the form of acute kidney injury (p=0.018), cytokine storm (pCONCLUSION. Overweight and/or obesity is a significant risk factor for severe course of the new coronavirus infection and the associated cardiovascular and kidney damage Overweight people and patients with the 1st and 2nd degree obesity tend to have a high risk of death of SARS-CoV-2 infection in both acute and post-covid periods. On top of that, in case of morbid obesity patients this tendency is statistically significant. Normalization of body weight is a strategic objective of modern medicine and can contribute to prevention of respiratory conditions, severe course and complications of the new coronavirus infection.
Published: 2023

11. Newly diagnosed diseases and the frequency of their occurrence in patients after a new coronavirus infection. Results of an International Register "Dynamics Analysis of Comorbidities in SARS-CoV-2 Survivors (ACTIV SARS-CoV-2)" (12-month follow-up)

Author: Arutyunov, G. P., primary, Tarlovskaya, E. I., additional, Arutyunov, A. G., additional, Polyakov, D. S., additional, Belenkov, Yu. N., additional, Konradi, A. O., additional, Lopatin, Yu. M., additional, Rebrov, A. P., additional, Tereshchenko, S. N., additional, Chesnikova, A. I., additional, Hayrapetyan, H. G., additional, Babin, A. P., additional, Bakulin, I. G., additional, Bakulina, N. V., additional, Balykova, L. A., additional, Blagonravova, A. S., additional, Boldina, M. V., additional, Butomo, M. I., additional, Vaisberg, A. R., additional, Galyavich, A. S., additional, Gomonova, V. V., additional, Grigoryeva, N. Yu., additional, Gubareva, I. V., additional, Demko, I. V., additional, Evzerikhina, A. V., additional, Zharkov, A. V., additional, Zateishchikova, A. A., additional, Kamilova, U. K., additional, Kim, Z. F., additional, Kuznetsova, T. Yu., additional, Kulikov, A. N., additional, Lareva, N. V., additional, Makarova, E. V., additional, Malchikova, S. V., additional, Nedogoda, S. V., additional, Petrova, M. M., additional, Pochinka, I. G., additional, Protasov, K. V., additional, Protsenko, D. N., additional, Ruzanov, D. Yu., additional, Saiganov, S. A., additional, Sarybaev, A. Sh., additional, Selezneva, N. M., additional, Sugraliev, A. B., additional, Fomin, I. V., additional, Khlynova, O. V., additional, Chizhova, O. Yu., additional, Shaposhnik, I. I., additional, Schukarev, D. A., additional, Abdrakhmanova, A. K., additional, Avetisyan, S. A., additional, Avoyan, H. G., additional, Azaryan, K. K., additional, Aimakhanova, G. T., additional, Ayypova, D. A., additional, Akunov, A. Ch., additional, Alieva, M. K., additional, Almukhambedova, A. R., additional, Aparkina, O. Yu., additional, Aruslanova, O. R., additional, Ashina, E. Yu., additional, Badina, O. Yu., additional, Barysheva, O. Yu., additional, Batluk, T. I., additional, Batchaeva, A. S., additional, Bashkinov, R. A., additional, Bitieva, A. M., additional, Bikhteev, I. U., additional, Borodulina, N. A., additional, Bragin, M. V., additional, Brazhnik, V. A., additional, Budu, A. M., additional, Bykova, G. A., additional, Vagapova, K. R., additional, Varlamova, D. D., additional, Vezikova, N. N., additional, Verbitskaya, E. A., additional, Vilkova, O. E., additional, Vinnikova, E. .A., additional, Vustina, V. V., additional, Elena A. Galova, E. A., additional, Genkel, V. V., additional, Giller, D. B., additional, Gordeychuk, E. D., additional, Gorshenina, E. I., additional, Grigoryeva, E. V., additional, Gubareva, E. Yu., additional, Dabylova, G. M., additional, Demchenko, A. I., additional, Dolgikh, O. Yu., additional, Duishobaev, M. Y., additional, Evdokimov, D. S., additional, Egorova48, K. E., additional, Zheldybaeva, A. E., additional, Zarechnova, N. V., additional, Zimina, Yu. D., additional, Ivanova, S. Yu., additional, Ivanchenko, E. Yu., additional, Ilina, M. V., additional, Kazakovtseva, M. V., additional, Kazymova, E. V., additional, Yuliya S. Kalinina, Yu. S., additional, Kamardina, N. A., additional, Karachenova, A. M., additional, Karetnikov, I. A., additional, Karoli, N. A., additional, Karsiev, M. Kh., additional, Kaskaeva, D. S., additional, Kasymova, K. F., additional, Kerimbekova, Zh. B., additional, Kim, E. S., additional, Kiseleva, N. V., additional, Klimenko, D. A., additional, Kovalishena, O. V., additional, Kozlov, S. V., additional, Kolmakova, E. V., additional, Kolchinskaya, T. P., additional, Kolyadich, M. I., additional, Kondryakova, O. V., additional, Konoval, M. P., additional, Konstantinov, D. Yu., additional, Konstantinova, E. A., additional, Kordyukova, V. A., additional, Koroleva, E. V., additional, Kraposhina, A. Yu., additional, Kryukova, T. V., additional, Kuznetsova, A. S., additional, Kuzmina, T. Yu., additional, Kuzmichev, K. V., additional, Kulchoroeva, C. K., additional, Kuprina, T. V., additional, Kuranova, I. M., additional, Kurenkova, L. V., additional, Kurchugina, N. Yu., additional, Kushubakova, N. A., additional, Levankova, V. I., additional, Ledyaeva, A. A., additional, Lisun, T. V., additional, Lisyanskaya, V. E., additional, Lyubavina, N. A., additional, Magdeeva, N. A., additional, Mazalov, K. V., additional, Mayseenko, V. I., additional, Makarova, A. S., additional, Maripov, A. M., additional, Markov, N. V., additional, Marusina, A. A., additional, Melnikov, E. S., additional, Metlinskaya, A. I., additional, Moiseenko, N. B., additional, Muradova, F. N., additional, Muradyan, R. G., additional, Musaelyan, Sh. N., additional, Nekaeva, E. S., additional, Nikitina, N. M., additional, Nifontov, S. E., additional, Obolentseva, E. Yu., additional, Obukhova, A. A., additional, Ogurlieva, B. B., additional, Odegova, A. A., additional, Yuliya V. Omarova, Yu. V., additional, Omurzakova, N. A., additional, Ospanova, Sh. O., additional, Pavlova, V. A/, additional, Pakhomova, E. V., additional, Petrov, L. D., additional, Plastinina, S. S., additional, Platonov, D. A., additional, Pogrebetskaya, V. A., additional, Polyakov, D. V., additional, Ponomarenko, E. V., additional, Popova, L. L., additional, Potanin, A. A., additional, Prokofieva, N. A., additional, Rabik, Yu. D., additional, Rakov, N. A., additional, Rakhimov, A. N., additional, Rozanova, N. A., additional, Serikbolkyzy, S., additional, Sidorkina, Ya. A., additional, Simonov, A. A., additional, Skachkova, V. V., additional, Skvortsova, R. D., additional, Skuridin, D. S., additional, Solovieva, D. V., additional, Solovieva, I. A., additional, Sukhomlinova, I. M., additional, Sushilova, A. G., additional, Tagaeva, D. R., additional, Tikhonova, E. P., additional, Tokmin, D. S., additional, Tolmacheva, A. A., additional, Torgunakova, M. S., additional, Trenogina, K. V., additional, Trostyanetskaya, N. A., additional, Trofimov, D. A., additional, Trubnikova, M. A., additional, Tulichev, A. A., additional, Tursunova, A. T., additional, Ulanova, N. D., additional, Fatenkov, O. V., additional, Fedorishina, O. V., additional, Fil, T. S., additional, Fomina, I. Yu., additional, Fominova, I. S., additional, Frolova, I. A., additional, Tsvinger, S. M., additional, Tsoma, V. V., additional, Cholponbaeva, M. B., additional, Chudinovskikh, T. I., additional, Shavrin, I. V., additional, Shevchenko, O. A., additional, Shikhaliev, D. R., additional, Shishkina, E. A., additional, Shishkov, K. Yu., additional, Shcherbakov, S. Yu, additional, Shcherbakova, G. V., additional, and Yausheva, E. A., additional
Published: 2023
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12. The impact of BMI on the course of the acute SARS-COV-2 infection and the risks that emerge during the first year after the hospital discharge. Subanalysis evidence of the AKTIV and AKTIV 2 registries

Author: Arutyunov, A. G., primary, Tarlovskaya, E. I., additional, Galstyan, G. R., additional, Batluk, T. I., additional, Bashkinov, R. A., additional, Arutyunov, G. P., additional, Belenkov, Yu. N., additional, Konradi, A. O., additional, Lopatin, Yu. M., additional, Rebrov, A. P., additional, Tereshchenko, S. N., additional, Chesnikova, A. I., additional, Hayrapetyan, H. G., additional, Babin, A. P., additional, Bakulin, I. G., additional, Bakulina, N. V., additional, Balykova, L. A., additional, Blagonravova, A. S., additional, Boldina, M. V., additional, Butomo, M. I., additional, Vaisberg, A. R., additional, Galyavich, A. S., additional, Gomonova, V. V., additional, Grigoryeva, N. Yu., additional, Gubareva, I. V., additional, Demko, I. V., additional, Evzerikhina, A. V., additional, Zharkov, A. V., additional, Zateishchikova, A. A., additional, Kamilova, U. K., additional, Kim, Z. F., additional, Kuznetsova, T. Yu., additional, Kulikov, A. N., additional, Lareva, N. V., additional, Makarova, E. V., additional, Malchikova, S. V., additional, Nedogoda, S. V., additional, Petrova, M. M., additional, Pochinka, I. G., additional, Protasov, K. V., additional, Protsenko, D. N., additional, Ruzanov, D. Yu., additional, Saiganov, S. A., additional, Sarybaev, A. Sh., additional, Selezneva, N. M., additional, Sugraliev, A. B., additional, Fomin, I. V., additional, Khlynova, O. V., additional, Chizhova, O. Yu., additional, Shaposhnik, I. I., additional, Schukarev, D. A., additional, Abdrakhmanova, A. K., additional, Avetisyan, S. A., additional, Avoyan, H. G., additional, Azaryan, K. K., additional, Aimakhanova, G. T., additional, Ayypova, D. A., additional, Akunov, A. Ch., additional, Alieva, M. K., additional, Almukhambedova, A. R., additional, Aparkina, A. V., additional, Aruslanova, O. R., additional, Ashina, E. Yu., additional, Badina, O. Yu., additional, Barysheva, O. Yu., additional, Batchaeva, A. S., additional, Bitieva, A. M., additional, Bikhteev, I. U., additional, Borodulina, N. A., additional, Bragin, M. V., additional, Brazhnik, V. A., additional, Budu, A. M., additional, Bykova, G. A., additional, Vagapova, K. R., additional, Varlamova, D. D., additional, Vezikova, N. N., additional, Verbitskaya, E. A., additional, Vilkova, O. E., additional, Vinnikova, E. A., additional, Vustina, V. V., additional, Galova, E. A., additional, Genkel, V. V., additional, Giller, D. B., additional, Gorshenina, E. I., additional, Grigoryeva, E. V., additional, Gubareva, E. Yu., additional, Dabylova, G. M., additional, Demchenko, A. I., additional, Dolgikh, O. Yu., additional, Duishobaev, M. Y., additional, Evdokimov, D. S., additional, Egorova, K. E., additional, Ermilova, A. N., additional, Zheldybaeva, A. E., additional, Zarechnova, N. V., additional, Zimina, Yu. D., additional, Ivanova, S. Yu., additional, Ivanchenko, E. Yu., additional, Ilina, M. V., additional, Kazakovtseva, M. V., additional, Kazymova, E. V., additional, Kalinina, Yu. S., additional, Kamardina, N. A., additional, Karachenova, A. M., additional, Karetnikov, I. A., additional, Karoli, N. A., additional, Karsiev, M. Kh., additional, Kaskaeva, D. S., additional, Kasymova, K. F., additional, Kerimbekova, Zh. B., additional, Kim, E. S., additional, Kiseleva, N. V., additional, Klimenko, D. A., additional, Klimova, A. V., additional, Kovalishena, O. V., additional, Kozlov, S. V., additional, Kolmakova, E. V., additional, Kolchinskaya, T. P., additional, Kolyadich, M. I., additional, Kondryakova, O. V., additional, Konoval, M. P., additional, Konstantinov, D. Yu., additional, Konstantinova, E. A., additional, Kordyukova, V. A., additional, Koroleva, E. V., additional, Kraposhina, A. Yu., additional, Kryukova, T. V., additional, Kuznetsova, A. S., additional, Kuzmina, T. Yu., additional, Kuzmichev, K. V., additional, Kulchoroeva, Ch. K., additional, Kuprina, T. V., additional, Kuranova, I. M., additional, Kurenkova, L. V., additional, Kurchugina, N. Yu., additional, Kushubakova, N. A., additional, Levankova, V. I., additional, Ledyaeva, A. A., additional, Lisun, T. V., additional, Lisyanskaya, V. E., additional, Lyubavina, N. A., additional, Magdeeva, N. A., additional, Mazalov, K. V., additional, Mayseenko, V. I., additional, Makarova, A. S., additional, Maripov, A. M., additional, Markov, N. V., additional, Marusina, A. A., additional, Melnikov, E. S., additional, Metlinskaya, A. I., additional, Moiseenko, N. B., additional, Muradova, F. N., additional, Muradyan, R. G., additional, Musaelyan, Sh. N., additional, Nekaeva, E. S., additional, Nikitina, N. M., additional, Nifontov, S. E., additional, Obolentseva, E. Yu., additional, Obukhova, A. A., additional, Ogurlieva, B. B., additional, Odegova, A. A., additional, Omarova, Yu. V., additional, Omurzakova, N. A., additional, Ospanova, Sh. O., additional, Pavlova, V. A., additional, Pakhomova, E. V., additional, Petrov, L. D., additional, Plastinina, S. S., additional, Platonov, D. A., additional, Pogrebetskaya, V. A., additional, Polyakov, D. V., additional, Polyakov, D. S., additional, Ponomarenko, E. V., additional, Popova, L. L., additional, Potanin, A. A., additional, Prokofieva, N. A., additional, Rabik, Yu. D., additional, Rakov, N. A., additional, Rakhimov, A. N., additional, Rozanova, N. A., additional, Samus, I. V., additional, Serikbolkyzy, S., additional, Sidorkina, Ya. A., additional, Simonov, A. A., additional, Skachkova, V. V., additional, Skvortsova, R. D., additional, Skuridin, D. S., additional, Solovieva, D. V., additional, Solovieva, I. A., additional, Sukhomlinova, I. M., additional, Sushilova, A. G., additional, Tagaeva, D. R., additional, Titoykina, Yu. V., additional, Tikhonova, E. P., additional, Tokmin, D. S., additional, Tolmacheva, A. A., additional, Torgunakova, M. S., additional, Trenogina, K. V., additional, Trostyanetskaya, N. A., additional, Trofimov, D. A., additional, Trubnikova, M. A., additional, Tulichev, A. A., additional, Tursunova, A. T., additional, Ulanova, N. D., additional, Fatenkov, O. V., additional, Fedorishina, O. V., additional, Fil, T. S., additional, Fomina, I. Yu., additional, Fominova, I. S., additional, Frolova, I. A., additional, Tsvinger, S. M., additional, Tsoma, V. V., additional, Cholponbaeva, M. B., additional, Chudinovskikh, T. I., additional, Shavrin, I. V., additional, Shevchenko, O. A., additional, Shikhaliev, D. R., additional, Shishkina, E. A., additional, Shishkov, K. Yu., additional, Shcherbakov, S. Yu., additional, Shcherbakova, G. V., additional, and Yausheva, E. A., additional
Published: 2023
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13. Microbiota in the pathogenesis of COPD and its impact on the course of the disease

Author: Vasilii D. Fedotov, A.V. Zhestkov, Artem V. Lyamin, M.I. Zaslavskaya, I.S. Dobrotina, and A.A. Tulichev
Subjects: Microbiology (medical), Infectious Diseases, Epidemiology, Pharmacology (medical)
Abstract: Chronic obstructive pulmonary disease (COPD) is a serious problem for global health. Infectious agents play a main role in the development of COPD exacerbations. Bacterial colonization of the lower respiratory tract is common in patients with stable COPD. The role of microbiota and host immune response to potential pathogens is not well studied. Microbiota composition disorders in respiratory tract are found in patients with COPD and associated with maladaptive changes in the immune system of the lungs and increased level of inflammation. This review investigates role of microbiota in the pathogenesis of COPD and its impact on the course of the disease. Some important issues such as pneumococcal vaccination and antimicrobial resistance of respiratory pathogens are also discussed.
Published: 2022

14. Complications of severe COVID-19 (dinical case)

Author: S. Plastinina, A. Tulichev, E. Makarova, N. Lyubavina, N. Menkov, E. Konyukhova, M. Chmuzh, A. Sidnev, D. Vasina, and M. Kuzmina
Subjects: Complementary and alternative medicine, Pharmaceutical Science, Pharmacology (medical)
Published: 2022

15. Clinical features of post-COVID period. Results of an International Register "Dynamics Analysis of Comorbidities in SARS-CoV-2 Survivors (ACTIV SARS-CoV-2)" (12-month follow-up)

Author: Arutyunov, G. P., primary, Tarlovskaya, E. I, additional, Arutyunov, A. G., additional, Belenkov, Yu. N., additional, Konradi, A. O., additional, Lopatin, Yu. M., additional, Rebrov, A. P., additional, Tereshchenko, S. N., additional, Chesnikova, A. I., additional, Hayrapetyan, H. G., additional, Babin, A. P., additional, Bakulin, I. G., additional, Bakulina, N. V., additional, Balykova, L. A., additional, Blagonravova, A. S., additional, Boldina, M. V., additional, Butomo, M. I., additional, Vaisberg, A. R., additional, Galyavich, A. S., additional, Gomonova, V. V., additional, Grigorieva, N. Yu., additional, Gubareva, I. V., additional, Demko, I. V., additional, Evzerikhina, A. V., additional, Zharkov, A. V., additional, Zateishchikova, A. A., additional, Kamilova, U. K., additional, Kim, Z. F., additional, Kuznetsova, T. Yu., additional, Kulikov, A. N., additional, Lareva, N. V., additional, Makarova, E. V., additional, Malchikova, S. V., additional, Nedogoda, S. V., additional, Petrova, M. M., additional, Pochinka, I. G., additional, Protasov, K. V., additional, Protsenko, D. N., additional, Ruzanav, D. Yu., additional, Sayganov, S. A., additional, Sarybaev, A. Sh., additional, Selezneva, N. M., additional, Sugraliev, A. B., additional, Fomin, I. V., additional, Khlynova, O. V., additional, Chizhova, O. Yu., additional, Shaposhnik, I. I., additional, Sh'ukarev, D. A., additional, Abdrakhmanova, A. K., additional, Avetisian, S. A., additional, Avoyan, H. G., additional, Azarian, K. K., additional, Aimakhanova, G. T., additional, Ayipova, D. A., additional, Akunov, A. Ch., additional, Alieva, M. K., additional, Almukhambedova, A. R., additional, Aparkina, A. V., additional, Aruslanova, O. R., additional, Ashina, E. Yu., additional, Badina, O. Yu., additional, Barysheva, O. Yu., additional, Batluk, T. I., additional, Batchayeva, A. S., additional, Bashkinov, R. A., additional, Bitieva, A. M., additional, Bikhteyev, I. U., additional, Borodulina, N. A., additional, Bragin, M. V., additional, Brazhnik, V. A., additional, Budu, A. M., additional, Bykova, G. A., additional, Vagapova, K. R., additional, Varlamova, D. D., additional, Vezikova, N. N., additional, Verbitskaya, E. A., additional, Vilkova, O. E., additional, Vinnikova, E. A., additional, Vustina, V. V., additional, Gаlova, E. A., additional, Genkel, V. V, additional, Giller, D. B., additional, Gorshenina, E. I., additional, Grigorieva, E. V., additional, Gubareva, E. U., additional, Dabylova, G. M., additional, Demchenko, A. I., additional, Dolgikh, O. Yu., additional, Duyshobayev, M. Y., additional, Evdokimov, D. S., additional, Egorova, K. E., additional, Zheldybayeva, A. E., additional, Zarechnova, N. V., additional, Zimina, Yu. D., additional, Ivanova, S. U., additional, Ivanchenko, E. U., additional, Ilina, M. V., additional, Kazakovtseva, M. V., additional, Kazymova, E. V., additional, Kalinina, Yu. S., additional, Kamardina, N. A., additional, Karachenova, A. M., additional, Karetnikov, I. A., additional, Karoli, N. A., additional, Karsiev, M. Kh., additional, Кaskaeva, D. S., additional, Kasymova, K. F., additional, Kerimbekova, Zh. B., additional, Kim, E. S., additional, Kiseleva, N. V., additional, Klimenko, D. A., additional, Kovalishena, O. V., additional, Kozlov, S. V., additional, Kolmakova, E. V., additional, Kolchinskaya, T. P., additional, Koliadich, M. I., additional, Kondriakova, O. V., additional, Konoval, M. P., additional, Konstantinov, D. U., additional, Konstantinova, E. A., additional, Kordukova, V. A., additional, Koroleva, E. V., additional, Kraposhina, A. U., additional, Kryukova, T. V., additional, Kuznetsova, A. S., additional, Kuzmina, T. U., additional, Kuzmichev, K. V., additional, Kulchoroeva, Ch. K., additional, Kuprina, T. V., additional, Kuranova, I. M., additional, Kurenkova, L. V., additional, Kurchugina, N. U., additional, Kushubakova, N. A., additional, Levankova, V. I., additional, Ledyaeva, A. A., additional, Lisun, T. V., additional, Lisyanskaya, V. E., additional, Lyubavina, N. A., additional, Magdeyeva, N. A., additional, Mazalov, K. V., additional, Maiseenko, V. I., additional, Makarova, A. S., additional, Maripov, A. M., additional, Markov, N. V., additional, Marusina, A. A., additional, Melnikov, E. S., additional, Metlinskaya, A. I., additional, Moiseenko, N. B., additional, Muradova, F. N., additional, Muradyan, R. G., additional, Musaelian, Sh. N., additional, Nekaeva, E. S., additional, Nikitina, N. M., additional, Nifontov, S. E., additional, Obolentseva, E. U., additional, Obukhova, A. A., additional, Ogurlieva, B. B., additional, Odegova, A. A., additional, Omarova, Yu. V., additional, Omurzakova, N. A., additional, Ospanova, Sh. O., additional, Pavlova, V. A., additional, Pahomova, E. V., additional, Petrov, L. D., additional, Plastinina, S. S., additional, Platonov, D. A., additional, Pogrebetskaya, V. A., additional, Polyakov, D. V., additional, Polyakov, D. S., additional, Ponomarenko, E. V., additional, Popova, L. L., additional, Potanin, A. A., additional, Prokofeva, N. A., additional, Rabik, J. D., additional, Rakov, N. A., additional, Rakhimov, A. N., additional, Rozanova, N. A., additional, Samus, I. V., additional, Serikbolkyzy, S., additional, Sidorkina, Ya. A., additional, Simonov, A. A., additional, Skachkova, V. V., additional, Skvortcova, R. D., additional, Skuridin, D. S., additional, Solovieva, D. V., additional, Solovieva, I. A., additional, Sukhomlinova, I. M., additional, Sushilova, A. G., additional, Tagayeva, D. R., additional, Tikhonova, E. P., additional, Tokmin, D. S., additional, Tolmacheva, A. A., additional, Torgunakova, M. S., additional, Trenogina, K. V., additional, Trostianetckaia, N. A., additional, Trofimov, D. A., additional, Trubnikova, M. A., additional, Tulichev, A. A., additional, Tursunova, A. T., additional, Ulanova, N. D., additional, Fatenkov, O. V., additional, Fedorishina, O. V., additional, Fil, T. S., additional, Fomina, I. U., additional, Fominova, I. S., additional, Frolova, I. A., additional, Tsvinger, S. M., additional, Tsoma, V. V., additional, Cholponbaeva, M. B., additional, Chudinovskikh, T. I., additional, Shavrin, I. V., additional, Shevchenko, O. A., additional, Shikhaliev, D. R., additional, Shishkina, E. A., additional, Shishkov, K. U., additional, Sherbakov, S. U., additional, Shcherbakova, G. V., additional, and Yausheva, E. A., additional
Published: 2022
Full Text: View/download PDF

16. Newly diagnosed diseases and the frequency of their occurrence in patients after a new coronavirus infection. Results of an International Register 'Dynamics Analysis of Comorbidities in SARS-CoV-2 Survivors (ACTIV SARS-CoV-2)' (12-month follow-up)

Author: G. P. Arutyunov, E. I. Tarlovskaya, A. G. Arutyunov, D. S. Polyakov, Yu. N. Belenkov, A. O. Konradi, Yu. M. Lopatin, A. P. Rebrov, S. N. Tereshchenko, A. I. Chesnikova, H. G. Hayrapetyan, A. P. Babin, I. G. Bakulin, N. V. Bakulina, L. A. Balykova, A. S. Blagonravova, M. V. Boldina, M. I. Butomo, A. R. Vaisberg, A. S. Galyavich, V. V. Gomonova, N. Yu. Grigoryeva, I. V. Gubareva, I. V. Demko, A. V. Evzerikhina, A. V. Zharkov, A. A. Zateishchikova, U. K. Kamilova, Z. F. Kim, T. Yu. Kuznetsova, A. N. Kulikov, N. V. Lareva, E. V. Makarova, S. V. Malchikova, S. V. Nedogoda, M. M. Petrova, I. G. Pochinka, K. V. Protasov, D. N. Protsenko, D. Yu. Ruzanov, S. A. Saiganov, A. Sh. Sarybaev, N. M. Selezneva, A. B. Sugraliev, I. V. Fomin, O. V. Khlynova, O. Yu. Chizhova, I. I. Shaposhnik, D. A. Schukarev, A. K. Abdrakhmanova, S. A. Avetisyan, H. G. Avoyan, K. K. Azaryan, G. T. Aimakhanova, D. A. Ayypova, A. Ch. Akunov, M. K. Alieva, A. R. Almukhambedova, O. Yu. Aparkina, O. R. Aruslanova, E. Yu. Ashina, O. Yu. Badina, O. Yu. Barysheva, T. I. Batluk, A. S. Batchaeva, R. A. Bashkinov, A. M. Bitieva, I. U. Bikhteev, N. A. Borodulina, M. V. Bragin, V. A. Brazhnik, A. M. Budu, G. A. Bykova, K. R. Vagapova, D. D. Varlamova, N. N. Vezikova, E. A. Verbitskaya, O. E. Vilkova, E. .A. Vinnikova, V. V. Vustina, E. A. Elena A. Galova, V. V. Genkel, D. B. Giller, E. D. Gordeychuk, E. I. Gorshenina, E. V. Grigoryeva, E. Yu. Gubareva, G. M. Dabylova, A. I. Demchenko, O. Yu. Dolgikh, M. Y. Duishobaev, D. S. Evdokimov, K. E. Egorova48, A. E. Zheldybaeva, N. V. Zarechnova, Yu. D. Zimina, S. Yu. Ivanova, E. Yu. Ivanchenko, M. V. Ilina, M. V. Kazakovtseva, E. V. Kazymova, Yu. S. Yuliya S. Kalinina, N. A. Kamardina, A. M. Karachenova, I. A. Karetnikov, N. A. Karoli, M. Kh. Karsiev, D. S. Kaskaeva, K. F. Kasymova, Zh. B. Kerimbekova, E. S. Kim, N. V. Kiseleva, D. A. Klimenko, O. V. Kovalishena, S. V. Kozlov, E. V. Kolmakova, T. P. Kolchinskaya, M. I. Kolyadich, O. V. Kondryakova, M. P. Konoval, D. Yu. Konstantinov, E. A. Konstantinova, V. A. Kordyukova, E. V. Koroleva, A. Yu. Kraposhina, T. V. Kryukova, A. S. Kuznetsova, T. Yu. Kuzmina, K. V. Kuzmichev, C. K. Kulchoroeva, T. V. Kuprina, I. M. Kuranova, L. V. Kurenkova, N. Yu. Kurchugina, N. A. Kushubakova, V. I. Levankova, A. A. Ledyaeva, T. V. Lisun, V. E. Lisyanskaya, N. A. Lyubavina, N. A. Magdeeva, K. V. Mazalov, V. I. Mayseenko, A. S. Makarova, A. M. Maripov, N. V. Markov, A. A. Marusina, E. S. Melnikov, A. I. Metlinskaya, N. B. Moiseenko, F. N. Muradova, R. G. Muradyan, Sh. N. Musaelyan, E. S. Nekaeva, N. M. Nikitina, S. E. Nifontov, E. Yu. Obolentseva, A. A. Obukhova, B. B. Ogurlieva, A. A. Odegova, Yu. V. Yuliya V. Omarova, N. A. Omurzakova, Sh. O. Ospanova, V. A/ Pavlova, E. V. Pakhomova, L. D. Petrov, S. S. Plastinina, D. A. Platonov, V. A. Pogrebetskaya, D. V. Polyakov, E. V. Ponomarenko, L. L. Popova, A. A. Potanin, N. A. Prokofieva, Yu. D. Rabik, N. A. Rakov, A. N. Rakhimov, N. A. Rozanova, S. Serikbolkyzy, Ya. A. Sidorkina, A. A. Simonov, V. V. Skachkova, R. D. Skvortsova, D. S. Skuridin, D. V. Solovieva, I. A. Solovieva, I. M. Sukhomlinova, A. G. Sushilova, D. R. Tagaeva, E. P. Tikhonova, D. S. Tokmin, A. A. Tolmacheva, M. S. Torgunakova, K. V. Trenogina, N. A. Trostyanetskaya, D. A. Trofimov, M. A. Trubnikova, A. A. Tulichev, A. T. Tursunova, N. D. Ulanova, O. V. Fatenkov, O. V. Fedorishina, T. S. Fil, I. Yu. Fomina, I. S. Fominova, I. A. Frolova, S. M. Tsvinger, V. V. Tsoma, M. B. Cholponbaeva, T. I. Chudinovskikh, I. V. Shavrin, O. A. Shevchenko, D. R. Shikhaliev, E. A. Shishkina, K. Yu. Shishkov, S. Yu Shcherbakov, G. V. Shcherbakova, and E. A. Yausheva
Subjects: Cardiology and Cardiovascular Medicine
Abstract: Aim. To analyze newly diagnosed diseases and features of the post-COVID course in patients after a coronavirus disease 2019 (COVID-19) within 12-month follow-up.Material and methods. A total of 9364 consecutively hospitalized patients were included in the ACTIV registry. Enrollment of patients began on June 29, 2020, and was completed on March 30, 2021, corresponding to the first and second waves of the pandemic. Demographic, clinical, and laboratory data, computed tomography (CT) results, information about inhospital clinical course and complications of COVID-19 during hospitalization were extracted from electronic health records using a standardized data collection form. The design included follow-up telephone interviews with a standard questionnaire at 3, 6, and 12 months to examine the course of post-COVID period.Results. According to the ACTIV registry, 18,1% of patients after COVID-19 had newly diagnosed diseases (NDDs) over the next 12 months. Hypertension (HTN), type 2 diabetes and coronary artery disease (CAD) prevailed in the NDD structure. Comparison of the age-standardized incidence of NDDs (HTN, CAD, diabetes) in the post-COVID period in the ACTIV registry with NDD incidence in 2019 according to Rosstat and the expected incidence of NDDs according to the EPOHA study revealed that HTN, diabetes, CAD in patients after COVID-19 were registered more often as follows: HTN by 7,0 and 4,4 times, diabetes by 7,3 and 8,8 times, CAD by 2,3 and 2,9 times, respectively. NDDs most often developed in patients aged 47 to 70 years. Comparison of the actual and expected number of cases of newly diagnosed HTN, CAD and diabetes depending on age showed that the actual number of cases in the population of patients in the ACTIV register is significantly higher than expected for patients aged 45-69 years and for patients with hypertension or diabetes and aged Conclusion. Available evidence suggests that a strategy for managing COVID-19 survivors should include mandatory screening for early detection of cardiovascular disease and diabetes, which will be key to reducing the risk of further COVID-19 consequences.
Published: 2023

17. CORONAVIRUS PANDEMIC: EXPERIENCE OF THE FIRST WAVE IN THE NIZHNY NOVGOROD REGION

Author: A. A. Tulichev, V. D. Fedotov, I. S. Dobrotina, D. N. Shakurova, and O. O. Fedotova
Subjects: medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), business.industry, Medical record, General Medicine, Disease, medicine.disease_cause, chemistry.chemical_compound, Tocilizumab, chemistry, Internal medicine, Concomitant, Pandemic, Medicine, business, Statistical processing, Coronavirus
Abstract: Aim: The aim of the study was to analyze the data from real clinical practice of diagnosis and treatment of a new coronavirus infection obtained during the first wave of the virus in Nizhny Novgorod Region. Material and methods: We analyzed 4,250 records in the regional register of patients with confirmed coronavirus infection. For detailed analysis, 184 medical records of inpatients of medical institutions in Nizhny Novgorod and Nizhny Novgorod region with a diagnosis of confirmed coronavirus infection of different course and outcome were randomly selected. Of these, we used as analyzed groups the patients discharged with improvement (recovered) (n1 = 86) and those who died (n2 = 98). All patients underwent medical examination according to the current temporary clinical guidelines for the diagnosis and treatment of COVID-19 new coronavirus infection. Statistical processing was performed using Microsoft Office software package (Excel), USA and Statistica 10.0 (Statsoft, USA). Results and discussion: Our data allowed us to conclude that the prognosis is favorably influenced by early hospitalization in the pulmonary stage of the disease, by early etiotropic and pathogenetic therapy, by the absence of concomitant disease, by adding systemic glucocorticosteroids on day 6-8 of hospitalization (which corresponds to the published data), and by tocilizumab. All patients received anticoagulants, but a more detailed analysis of the correlation of prescribed doses with prognosis is required to understand their impact on the outcome.
Published: 2021

18. Lipid profile in hospitalized patients with COVID-19 depending on the outcome of its acute phase: data from the international registry "Dynamics analysis of comorbidities in SARS-CoV-2 infection survivors"

Author: Arutyunov, G. P., primary, Tarlovskaya, E. I., additional, Arutyunov, A. G., additional, Belenkov, Yu. N., additional, Konradi, A. O., additional, Lopatin, Yu. M., additional, Rebrov, A. P., additional, Tereshchenko, S. N., additional, Chesnikova, A. I., additional, Airapetyan, G. G., additional, Babin, A. P., additional, Bakulin, I. G., additional, Bakulina, N. V., additional, Balykova, L. A., additional, Blagonravova, A. S., additional, Boldina, M. V., additional, Butomo, M. I., additional, Vaisberg, A. R., additional, Galyavich, A. S., additional, Gomonova, V. V., additional, Grigorieva, N. Yu., additional, Gubareva, I. V., additional, Demko, I. V., additional, Evzerikhina, A. V., additional, Zharkov, A. V., additional, Zateyshchikova, A. A., additional, Kamilova, U. K., additional, Kim, Z. F., additional, Kuznetsova, T. Yu., additional, Kulikov, A. N., additional, Lareva, N. V., additional, Makarova, E. V., additional, Malchikova, S. V., additional, Nedogoda, S. V., additional, Petrova, M. M., additional, Pochinka, I. G., additional, Protasov, K. V., additional, Protsenko, D. N., additional, Ruzanov, D. Yu., additional, Saiganov, S. A., additional, Sarybaev, A. Sh., additional, Selezneva, N. M., additional, Sugraliev, A. B., additional, Fomin, I. V., additional, Khlynova, O. V., additional, Chizhova, O. Yu., additional, Shaposhnik, I. I., additional, Schukarev, D. A., additional, Abdrakhmanova, A. K., additional, Avetisyan, S. A., additional, Avoyan, O. G., additional, Azaryan, K. K., additional, Aimakhanova, G. T., additional, Aiypova, D. A., additional, Akunov, A. Ch., additional, Alieva, M. K., additional, Almukhambedova, A. R., additional, Aparkina, A. V., additional, Aruslanova, O. R., additional, Ashina, E. Yu., additional, Badina, O. Yu., additional, Barysheva, O. Yu., additional, Batluk, T. I., additional, Batchaeva, A. S., additional, Bashkinov, R. A., additional, Bitieva, A. M., additional, Bikhteev, I. U., additional, Borodulina, N. A., additional, Bragin, M. V., additional, Brazhnik, V. A., additional, Budu, A. M., additional, Bykova, G. A., additional, Vagapova, K. R., additional, Varlamova, D. D., additional, Vezikova, N. N., additional, Verbitskaya, E. A., additional, Vilkova, O. E., additional, Vinnikova, E. A., additional, Vustina, V. V., additional, Galova, E. A., additional, Genkel, V. V., additional, Giller, D. B., additional, Gorshenina, E. I., additional, Grigoryeva, E. V., additional, Gubareva, E. Yu., additional, Dabylova, G. M., additional, Demchenko, A. I., additional, Dolgikh, O. Yu., additional, Duishobaev, M. Y., additional, Evdokimov, D. S., additional, Egorova, K. E., additional, Ermilova, A. N., additional, Zheldybaeva, A. E., additional, Zarechnova, N. V., additional, Zimina, Yu. D., additional, Ivanova, S. Yu., additional, Ivanchenko, E. Yu., additional, Ilyina, M. V., additional, Kazakovtseva, M. V., additional, Kazymova, E. V., additional, Kalinina, Yu. S., additional, Kamardina, N. A., additional, Karachenova, A. M., additional, Karetnikov, I. A., additional, Karoli, N. A., additional, Karsiev, M. Kh., additional, Kaskaeva, D. S., additional, Kasymova, K. F., additional, Kerimbekova, J. B., additional, Kim, E. S., additional, Kiseleva, N. V., additional, Klimenko, D. A., additional, Klimova, A. V., additional, Kovalishena, O. V., additional, Kozlov, S. V., additional, Kolmakova, E. V., additional, Kolchinskaya, T. P., additional, Kolyadich, M. I., additional, Kondryakova, O. V., additional, Konoval, M. P., additional, Konstantinov, D. Yu., additional, Konstantinova, E. A., additional, Kordyukova, V. A., additional, Koroleva, E. V., additional, Kraposhina, A. Yu., additional, Kryukova, T. V., additional, Kuznetsova, A. P., additional, Kuzmina, T. Yu., additional, Kuzmichev, K. V., additional, Kulchoroeva, Ch. K., additional, Kuprina, T. V., additional, Kuranova, I. M., additional, Kurenkova, L. V., additional, Kurchugina, N. Yu., additional, Kushubakova, N. A., additional, Levankova, V. I., additional, Ledyaeva, A. A., additional, Lisun, T. V., additional, Lisyanskaya, V. E., additional, Lyubavina, N. A., additional, Magdeeva, N. A., additional, Mazalov, K. V., additional, Mayseenko, V. I., additional, Makarova, A. S., additional, Maripov, A. M., additional, Markov, N. V., additional, Marusina, A. A., additional, Melnikov, E. S., additional, Metlinskaya, A. I., additional, Moiseenko, N. B., additional, Muradova, F. N., additional, Muradyan, R. G., additional, Musaelyan, Sh. N., additional, Nekaeva, E. S., additional, Nikitina, N. M., additional, Nifontov, S. E., additional, Obolentseva, E. Yu., additional, Obukhova, A. A., additional, Ogurlieva, B. B., additional, Odegova, A. A., additional, Omarova, Yu. V., additional, Omurzakova, N. A., additional, Ospanova, Sh. O., additional, Pavlova, V. A., additional, Pakhomova, E. V., additional, Petrov, L. D., additional, Plastinina, S. S., additional, Platonov, D. A., additional, Pogrebetskaya, V. A., additional, Polyakov, D. V., additional, Polyakov, D. S., additional, Ponomarenko, E. V., additional, Popova, L. L., additional, Potanin, A. A., additional, Prokofieva, N. A., additional, Rabik, Yu. D., additional, Rakov, N. A., additional, Rakhimov, A. N., additional, Rozanova, N. A., additional, Serikbolkyzy, S., additional, Sidorkina, Ya. A., additional, Simonov, A. A., additional, Skachkova, V. V., additional, Skvortsova, R. D., additional, Skuridin, D. S., additional, Solovieva, D. V., additional, Solovieva, I. A., additional, Sukhomlinova, I. M., additional, Sushilova, A. G., additional, Tagaeva, D. R., additional, Titoikina, Yu. V., additional, Tikhonova, E. P., additional, Tokmin, D. S., additional, Tolmacheva, A. A., additional, Torgunakova, M. S., additional, Trenogina, K. V., additional, Trostyanetskaya, N. A., additional, Trofimov, D. A., additional, Trubnikova, M. A., additional, Tulichev, A. A., additional, Tursunova, A. T., additional, Ulanova, N. D., additional, Fatenkov, O. V., additional, Fedorishina, O. V., additional, Fil, T. S., additional, Fomina, I. Yu., additional, Fominova, I. S., additional, Frolova, I. A., additional, Tsvinger, S. M., additional, Tsoma, V. V., additional, Cholponbaeva, M. B., additional, Chudinovskikh, T. I., additional, Shavrin, I. V., additional, Shevchenko, O. A., additional, Shikhaliev, D. R., additional, Shishkina, E. A., additional, Shishkov, K. Yu, additional, Shcherbakov, S. Yu., additional, Shcherbakova, G. V., additional, and Yausheva, E. A., additional
Published: 2022
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19. 16S rRNA gene sequencing data of the upper respiratory tract microbiome in the SARS-CoV-2 infected patients

Author: Galeeva, Julia, primary, Babenko, Vladislav, additional, Bakhtyev, Ramiz, additional, Baklaushev, Vladimir, additional, Balykova, Larisa, additional, Bashkirov, Pavel, additional, Bespyatykh, Julia, additional, Blagonravova, Anna, additional, Boldyreva, Daria, additional, Fedorov, Dmitry, additional, Gafurov, Ilshat, additional, Gaifullina, Raushaniya, additional, Galova, Elena, additional, Gospodaryk, Alina, additional, Ilina, Elena, additional, Ivanov, Konstantin, additional, Kharlampieva, Daria, additional, Khromova, Polina, additional, Klimina, Ksenia, additional, Kolontarev, Konstantin, additional, Kolyshkina, Nadezhda, additional, Koritsky, Andrey, additional, Kuropatkin, Vyacheslav, additional, Lazarev, Vasily, additional, Manolov, Alexander, additional, Manuvera, Valentin, additional, Matyushkina, Daria, additional, Morozov, Maxim, additional, Moskaleva, Ekaterina, additional, Musarova, Varvara, additional, Ogarkov, Oleg, additional, Orlova, Elizaveta, additional, Pavlenko, Alexander, additional, Petrova, Alla, additional, Pozhenko, Natalia, additional, Pushkar, Dmitry, additional, Rumyantsev, Alexander, additional, Rumyantsev, Sergey, additional, Rumyantsev, Vladimir, additional, Rychkova, Lyubov, additional, Samoilov, Alexander, additional, Shirokova, Irina, additional, Sinkov, Vyacheslav, additional, Solovieva, Svetlana, additional, Starikova, Elizaveta, additional, Tikhonova, Polina, additional, Trifonova, Galina, additional, Troitsky, Alexander, additional, Tulichev, Alexander, additional, Udalov, Yuri, additional, Varizhuk, Anna, additional, Vasiliev, Alexander, additional, Veselovsky, Vladimir, additional, Vereshchagin, Rinat, additional, Volnukhin, Alexey, additional, Yusubalieva, Gaukhar, additional, and Govorun, Vadim, additional
Published: 2022
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20. ACTIV SARS-CoV-2 registry (Analysis of Chronic Non-infectious Diseases Dynamics After COVID-19 Infection in Adult Patients). Assessment of impact of combined original comorbid diseases in patients with COVID-19 on the prognosis

Author: Arutyunov, Gregory P., primary, Tarlovskaya, Ekaterina I., additional, Arutyunov, Alexander G., additional, Belenkov, Yuri N., additional, Konradi, Alexandra O., additional, Lopatin, Yury M., additional, Rebrov, Andrey P., additional, Tereshchenko, Sergey N., additional, Chesnikova, Anna I., additional, Hayrapetyan, Hamlet G., additional, Babin, Aleksandr P., additional, Bakulin, Igor G., additional, Bakulina, Natalia V., additional, Balykova, Larisa A., additional, Blagonravova, Anna S., additional, Boldina, Marina V., additional, Vaisberg, Alexandra R., additional, Galyavich, Albert S., additional, Gomonova, Veronika V., additional, Grigorieva, Natalia Yu., additional, Gubareva, Irina V., additional, Demko, Irina V., additional, Evzerikhina, Angelika V., additional, Zharkov, Aleksandr V., additional, Kamilova, Umida K., additional, Kim, Zulfia F., additional, Kuznetsova, Tatiana Yu., additional, Lareva, Natalia V., additional, Makarova, Ekaterina V., additional, Malchikova, Svetlana V., additional, Nedogoda, Sergey V., additional, Petrova, Marina M., additional, Pochinka, Ilya G., additional, Protasov, Konstantin V., additional, Protsenko, Denis N., additional, Ruzanau, Dmitry Yu., additional, Sayganov, Sergey A., additional, Sarybaev, Akpay S., additional, Selezneva, Natalia M., additional, Sugraliev, Akhmetzhan B., additional, Fomin, Igor V., additional, Khlynova, Olga V., additional, Chizhova, Olga Yu., additional, Shaposhnik, Igor I., additional, Sh'ukarev, Dmitry A., additional, Abdrahmanova, Айгуль K., additional, Avetisian, Susanna A., additional, Avoyan, Hovhannes G., additional, Azarian, Karine K., additional, Aimakhanova, Galiya T., additional, Ayipova, Dinara A., additional, Akunov, Almazbek Ch., additional, Alieva, Marianna K., additional, Aparkina, Aliona V., additional, Aruslanova, Olga R., additional, Ashina, Ekaterina Yu., additional, Badina, Olga Yu., additional, Barisheva, Olga Yu., additional, Batchayeva, Alina S., additional, Bitieva, Anna M., additional, Bikhteyev, Ismail U., additional, Borodulina, Nataliya A., additional, Bragin, Maksim V., additional, Budu, Angela M., additional, Bykova, Galina M., additional, Vagapova, Kristina R., additional, Varlamova, Darina D., additional, Vezikova, Natalia N., additional, Verbitskaya, Elena A., additional, Vilkova, Olga E., additional, Vinnikova, Elena A., additional, Vustina, Vera V., additional, Galova, Elena A., additional, Genkel, Vadim V., additional, Gorshenina, Elena I., additional, Gostishev, Roman V., additional, Grigorieva, Elena V., additional, Gubareva, Ekaterina Yu., additional, Dabylova, Gaukhar M., additional, Demchenko, Anastasiya I., additional, Dolgikh, Oleg Yu., additional, Duyshobayev, Melis Y., additional, Evdokimov, Dmitrii S., additional, Egorova, Ksenia E., additional, Ermilova, Anastasiia N., additional, Zheldybayeva, Aliya E., additional, Zarechnova, Nataliya V., additional, Zimina, Yuliia D., additional, Ivanova, Svetlana Yu., additional, Ivanchenko, Elena Yu., additional, Ilina, Mariya V., additional, Kazakovtseva, Maria V., additional, Kazymova, Elena V., additional, Kalinina, Yuliya S., additional, Kamardina, Nadezhda A., additional, Karachenova, Anastasiya M., additional, Karetnikov, Igor A., additional, Karoli, Nina A., additional, Karsiev, Magomed Kh., additional, Кaskaeva, Daria S., additional, Kasymova, Karina F., additional, Kerimbekova, Zhainagul B., additional, Kerimova, Ailar Sh., additional, Kim, Eugeni S., additional, Kiseleva, Nina V., additional, Klimenko, Darya A., additional, Klimova, Anastasiia V., additional, Kovalishena, Olga V., additional, Kolmakova, Elena V., additional, Kolchinskaya, Tatyana P., additional, Kolyadich, Maria I., additional, Kondriakova, Olga V., additional, Konoval, Marina P., additional, Konstantinov, Dmitryi Yu., additional, Konstantinova, Elena A., additional, Kordukova, Vera A., additional, Koroleva, Ekaterina V., additional, Kraposhina, Angelina Yu., additional, Kriukova, Tamara V., additional, Kuznetsova, Alla S., additional, Kuzmina, Tatyana Yu., additional, Kuzmichev, Kirill V., additional, Kulchoroevna, Cholpon K., additional, Kuprina, Tatiana V., additional, Kouranova, Irina M., additional, Kurenkova, Liliya V., additional, Kurchugina, Natalia Yu., additional, Kushubakova, Nadira A., additional, Levankova, Valeriia I., additional, Lyubavina, Natalia A., additional, Magdeyeva, Nadezhda A., additional, Mazalov, Konstantin V., additional, Majseenko, Viktoryia I., additional, Makarova, Aleksandra S., additional, Maripov, Abdirashit M., additional, Marusina, Anastasiia A., additional, Melnikov, Evgenii S., additional, Moiseenko, Nikita B., additional, Muradova, Fazliniso N., additional, Muradyan, Rimma G., additional, Musaelian, Shahane N., additional, Myshak, Anton O., additional, Nekaeva, Ekaterina S., additional, Nikitina, Nataliia M., additional, Ogurlieva, Bela B., additional, Odegova, Alla A., additional, Omarova, Yuliia V., additional, Omurzakova, Nazgul A., additional, Ospanova, Shynar O., additional, Pahomova, Ekaterina V., additional, Petrov, Liviu D., additional, Plastinina, Svetlana S., additional, Pogrebetskaya, Vera A., additional, Polyakov, Dmitry S., additional, Ponomarenko, Ekaterina V., additional, Popova, Larisa L., additional, Prokofeva, Natalya A., additional, Pudova, Inna A., additional, Rakov, Nikita A., additional, Rahimov, Abdurakhmon N., additional, Rozanova, Nadezhda A., additional, Serikbolkyzy, Saltanat, additional, Simonov, Andrei A, additional, Skachkova, Valeriya V., additional, Soloveva, Daria V., additional, Soloveva, Irina A., additional, Subbotin, Alexander K., additional, Sukhomlinova, Irina M., additional, Sushilova, Anastasiia G., additional, Tagayeva, Dilnoza R., additional, Titojkina, Yuliia V., additional, Tikhonova, Elena P., additional, Tokmin, Danil S., additional, Tolmacheva, Anastasiia A., additional, Torgunakova, Mariya S., additional, Trenogina, Ksenia V., additional, Trostianetckaia, Natalia A., additional, Trofimov, Dmitriy A., additional, Tulichev, Alexander A., additional, Tursunova, Assiya T., additional, Ulanova, Nina D., additional, Fatenkov, Oleg V., additional, Fedorishina, Olga V., additional, Fil, Tatiana S., additional, Fomina, Irina Yu., additional, Fominova, Irina S., additional, Frolova, Irina A., additional, Tsvinger, Svetlana M., additional, Tsoma, Vera V., additional, Cholponbaeva, Meerim B., additional, Chudinovskikh, Tatiana I., additional, Shevchenko, Olga A., additional, Sheshina, Tatyana V., additional, Shishkina, Ekaterina A., additional, Shishkov, Konstantin Yu., additional, Sherbakov, Stanislav Yu., additional, and Yausheva, Ekaterina A., additional
Published: 2022
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21. Microbiota in the pathogenesis of COPD and its impact on the course of the disease

Author: Fedotov, Vasilii D., primary, Zhestkov, A.V., additional, Lyamin, Artem V., additional, Zaslavskaya, M.I., additional, Dobrotina, I.S., additional, and Tulichev, A.A., additional
Published: 2022
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22. Complications of severe COVID-19 (dinical case)

Author: Plastinina, S., primary, Tulichev, A., additional, Makarova, E., additional, Lyubavina, N., additional, Menkov, N., additional, Konyukhova, E., additional, Chmuzh, M., additional, Sidnev, A., additional, Vasina, D., additional, and Kuzmina, M., additional
Published: 2022
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23. Clinical features of post-COVID-19 period. Results of the international register “Dynamic analysis of comorbidities in SARS-CoV-2 survivors (AKTIV SARS-CoV-2)”. Data from 6-month follow-up

Author: Arutyunov, G. P., primary, Tarlovskaya, E. I., additional, Arutyunov, A. G., additional, Belenkov, Yu. N., additional, Konradi, A. O., additional, Lopatin, Yu. M., additional, Rebrov, A. P., additional, Tereshchenko, S. N., additional, Chesnikova, A. I., additional, Hayrapetyan, H. G., additional, Babin, A. P., additional, Bakulin, I. G., additional, Bakulina, N. V., additional, Balykova, L. A., additional, Blagonravova, A. S., additional, Boldina, M. V., additional, Vaisberg, A. R., additional, Galyavich, A. S., additional, Gomonova, V. V., additional, Grigorieva, N. Yu., additional, Gubareva, I. V., additional, Demko, I. V., additional, Evzerikhina, A. V., additional, Zharkov, A. V., additional, Kamilova, U. K., additional, Kim, Z. F., additional, Kuznetsova, T. Yu., additional, Lareva, N. V., additional, Makarova, E. V., additional, Malchikova, S. V., additional, Nedogoda, S. V., additional, Petrova, M. M., additional, Pochinka, I. G., additional, Protasov, K. V., additional, Protsenko, D. N., additional, Ruzanau, D. Yu., additional, Sayganov, S. A., additional, Sarybaev, A. Sh., additional, Selezneva, N. M., additional, Sugraliev, A. B., additional, Fomin, I. V., additional, Khlynova, O. V., additional, Chizhova, O. Yu., additional, Shaposhnik, I. I., additional, Shchukarev, D. A., additional, Abdrahmanova, A. K., additional, Avetisian, S. A., additional, Avoyan, H. G., additional, Azarian, K. K., additional, Aimakhanova, G. T., additional, Ayipova, D. A., additional, Akunov, A. Ch., additional, Alieva, M. K., additional, Aparkina, A. V., additional, Aruslanova, O. R., additional, Ashina, E. Yu., additional, Badina, O. Yu., additional, Barisheva, O. Yu., additional, Batluk, T. I., additional, Batchayeva, A. S., additional, Bashkinov, R. A., additional, Bitieva, A. M., additional, Bikhteyev, I. U., additional, Borodulina, N. A., additional, Bragin, M. V., additional, Budu, A. M., additional, Bykova, G. A., additional, Vagapova, K. R., additional, Varlamova, D. D., additional, Vezikova, N. N., additional, Verbitskaya, E. A., additional, Vilkova, O. E., additional, Vinnikova, E. A., additional, Vustina, V. V., additional, Gаlova, E. A., additional, Genkel, V. V., additional, Gorshenina, E. I., additional, Grigorieva, E. V., additional, Gubareva, E. Yu., additional, Dabylova, G. M., additional, Demchenko, I. A., additional, Dolgikh, O. Yu., additional, Duyshobayev, M. Y., additional, Evdokimov, D. S., additional, Egorova, K. E., additional, Ermilova, A. N., additional, Zheldybayeva, A. E., additional, Zarechnova, N. V., additional, Zimina, Yu. D., additional, Ivanova, S. Yu., additional, Ivanchenko, E. Yu., additional, Ilina, M. V., additional, Kazakovtseva, M. V., additional, Kazymova, E. V., additional, Kalinina, Yu. S., additional, Kamardina, N. A., additional, Karachenova, A. M., additional, Karetnikov, I. A., additional, Karoli, N. A., additional, Karsiev, M. K., additional, Кaskaeva, D. S., additional, Kasymova, K. F., additional, Kerimbekova, Zh. B., additional, Kerimova, A. Sh., additional, Kim, E. S., additional, Kiseleva, N. V., additional, Klimenko, D. A., additional, Klimova, A. V., additional, Kovalishena, O. V., additional, Kolmakova, E. V., additional, Kolchinskaya, T. P., additional, Kolyadich, M. I., additional, Kondriakova, O. V., additional, Konoval, M. P., additional, Konstantinov, D. Yu., additional, Konstantinova, E. A., additional, Kordukova, V. A., additional, Koroleva, E. V., additional, Kraposhina, A. Yu., additional, Kriukova, T. V., additional, Kuznetsova, A. S., additional, Kuzmina, T. Yu., additional, Kuzmichev, K. V., additional, Kulchoroeva, Ch. K., additional, Kuprina, T. V., additional, Kouranova, I. M., additional, Kurenkova, L. V., additional, Kurchugina, N. Yu., additional, Kushubakova, N. A., additional, Levankova, V. I., additional, Lyubavina, N. A., additional, Magdeyeva, N. A., additional, Mazalov, K. V., additional, Majseenko, V. I., additional, Makarova, A. S., additional, Maripov, A. M., additional, Marusina, A. A., additional, Melnikov, E. S., additional, Moiseenko, N. B., additional, Muradova, F. N., additional, Muradyan, R. G., additional, Musaelian, Sh. N., additional, Myshak, A. O., additional, Nekaeva, E. S., additional, Nikitina, N. M., additional, Ogurlieva, B. B., additional, Odegova, A. A., additional, Omarova, Yu. M., additional, Omurzakova, N. A., additional, Ospanova, Sh. O., additional, Pahomova, E. V., additional, Petrov, L. D., additional, Plastinina, S. S., additional, Pogrebetskaya, V. A., additional, Polyakov, D. V., additional, Polyakov, D. S., additional, Ponomarenko, E. V., additional, Popova, L. L., additional, Prokofeva, N. A., additional, Pudova, I. A., additional, Rakov, N. A., additional, Rakhimov, A. N., additional, Rozanova, N. A., additional, Serikbolkyzy, S., additional, Simonov, A. A., additional, Skachkova, V. V., additional, Soloveva, D. V., additional, Soloveva, I. A., additional, Sukhomlinova, I. M., additional, Sushilova, A. G., additional, Tagayeva, D. R., additional, Titojkina, Yu. V., additional, Tikhonova, E. P., additional, Tokmin, D. S., additional, Tolmacheva, A. A., additional, Torgunakova, M. S., additional, Trenogina, K. V., additional, Trostianetckaia, N. A., additional, Trofimov, D. A., additional, Trubnikova, M. A., additional, Tulichev, A. A., additional, Tursunova, A. T., additional, Ulanova, N. D., additional, Fatenkov, O. V., additional, Fedorishina, O. V., additional, Fil, T. S., additional, Fomina, I. Yu., additional, Fominova, I. S., additional, Frolova, I. A., additional, Tsvinger, S. M., additional, Tsoma, V. V., additional, Cholponbaeva, M. B., additional, Chudinovskikh, T. I., additional, Shevchenko, O. A., additional, Sheshina, T. V., additional, Shishkina, E. A., additional, Shishkov, K. Yu., additional, Sherbakov, S. Yu., additional, and Yausheva, E. A., additional
Published: 2021
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24. Analysis of the upper respiratory tract microbiota in mild and severe COVID-19 patients

Author: Rinat Irekovich Vereshchagin, Alla Germanovna Petrova, Elizaveta Andreevna Orlova, Dmitry Yurievich Pushkar, Larisa Alexandrovna Balykova, Polina Andreevna Khromova, Anna Sergeevna Blagonravova, Alexander Sergeevich Samoilov, Alina Vladimirovna Gospodaryk, Konstantin Borisovich Kolontarev, Vadim M. Govorun, Elena Anatolyevna Galova, Daria Igorevna Boldyreva, Vyacheslav Alexandrovich Kuropatkin, Ramiz Romanovich Bakhtyev, Alexander Alekseevich Tulichev, Oleg Borisovich Ogarkov, Vladimir Alexandrovich Rumyantsev, Alexander Grigorievich Rumyantsev, Vladislav V. Babenko, Svetlana Vladimirovna Solovieva, Vyacheslav Vladimirovich Sinkov, Natalia Sergeevna Pozhenko, Vladimir Pavlovich Baklaushev, Gaukhar Maratovna Yusubalieva, Vladimir A. Veselovsky, Andrey Vladimirovich Koritsky, Irina Yurievna Shirokova, Galina Sergeevna Trifonova, Dmitry E. Fedorov, Varvara Alexandrovna Musarova, Alexey Igorevich Volnukhin, Lyubov Vladimirovna Rychkova, Ksenia M. Klimina, Alexander Olegovich Vasiliev, Alexander I. Manolov, Elizaveta V. Starikova, Raushaniya Faritovna Gaifullina, Julia Bespyatykh, Alexander Vitalievich Troitsky, Sergey Aleksandrovich Rumyantsev, Vasily Nikolaevich Lazarev, P. O. Tikhonova, Daria Kharlampieva, Daria Matyushkina, Maxim Denisovich Morozov, Anna M. Varizhuk, Valentin A. Manuvera, Elena N. Ilina, Alexander V. Pavlenko, Nadezhda Aleksandrovna Kolyshkina, Konstantin Pavlovich Ivanov, Ekaterina Vladimirovna Moskaleva, Yuri Dmitrievich Udalov, Pavel Viktorovich Bashkirov, Julia Sergeevna Galeeva, and Ilshat Gafurov
Subjects: Multivariate analysis, Lung, Streptococcus, Disease, Biology, medicine.disease_cause, biology.organism_classification, medicine.anatomical_structure, Immune system, Immunology, medicine, Prevotella, Leptotrichia, Respiratory tract
Abstract: The microbiota of the respiratory tract remains a relatively poorly studied subject. At the same time, like the intestinal microbiota, it is involved in modulating the immune response to infectious agents in the host organism. A causal relationship between the composition of the respiratory microbiota and the likelihood of development and the severity of COVID-19 may be hypothesized. We analyze biomaterial from nasopharyngeal smears from 336 patients with a confirmed diagnosis of COVID-19, selected during the first and second waves of the epidemic in Russia. Sequences from a similar study conducted in Spain were also included in the analysis. We investigated associations between disease severity and microbiota at the level of microbial community (community types) and individual microbes (differentially represented species). To search for associations, we performed multivariate analysis, taking into account comorbidities, type of community and lineage of the virus. We found that two out of six community types are associated with a more severe course of the disease, and one of the community types is characterized by high stability (very similar microbiota profiles in different patients) and low level of lung damage. Differential abundance analysis with respect to comorbidities and community type suggested association of Rothia and Streptococcus genera representatives with more severe lung damage, and Leptotrichia, unclassified Lachnospiraceae and Prevotella with milder forms of the disease.
Published: 2021

25. [ACTIV SARS-CoV-2 registry (Analysis of Chronic Non-infectious Diseases Dynamics After COVID-19 Infection in Adult Patients). Assessment of impact of combined original comorbid diseases in patients with COVID-19 on the prognosis]

Author: Gregory P. Arutyunov, Ekaterina I. Tarlovskaya, Alexander G. Arutyunov, Yuri N. Belenkov, Alexandra O. Konradi, Yury M. Lopatin, Andrey P. Rebrov, Sergey N. Tereshchenko, Anna I. Chesnikova, Hamlet G. Hayrapetyan, Aleksandr P. Babin, Igor G. Bakulin, Natalia V. Bakulina, Larisa A. Balykova, Anna S. Blagonravova, Marina V. Boldina, Alexandra R. Vaisberg, Albert S. Galyavich, Veronika V. Gomonova, Natalia Yu. Grigorieva, Irina V. Gubareva, Irina V. Demko, Angelika V. Evzerikhina, Aleksandr V. Zharkov, Umida K. Kamilova, Zulfia F. Kim, Tatiana Yu. Kuznetsova, Natalia V. Lareva, Ekaterina V. Makarova, Svetlana V. Malchikova, Sergey V. Nedogoda, Marina M. Petrova, Ilya G. Pochinka, Konstantin V. Protasov, Denis N. Protsenko, Dmitry Yu. Ruzanau, Sergey A. Sayganov, Akpay S. Sarybaev, Natalia M. Selezneva, Akhmetzhan B. Sugraliev, Igor V. Fomin, Olga V. Khlynova, Olga Yu. Chizhova, Igor I. Shaposhnik, Dmitry A. Sh'ukarev, Айгуль K. Abdrahmanova, Susanna A. Avetisian, Hovhannes G. Avoyan, Karine K. Azarian, Galiya T. Aimakhanova, Dinara A. Ayipova, Almazbek Ch. Akunov, Marianna K. Alieva, Aliona V. Aparkina, Olga R. Aruslanova, Ekaterina Yu. Ashina, Olga Yu. Badina, Olga Yu. Barisheva, Alina S. Batchayeva, Anna M. Bitieva, Ismail U. Bikhteyev, Nataliya A. Borodulina, Maksim V. Bragin, Angela M. Budu, Galina M. Bykova, Kristina R. Vagapova, Darina D. Varlamova, Natalia N. Vezikova, Elena A. Verbitskaya, Olga E. Vilkova, Elena A. Vinnikova, Vera V. Vustina, Elena A. Galova, Vadim V. Genkel, Elena I. Gorshenina, Roman V. Gostishev, Elena V. Grigorieva, Ekaterina Yu. Gubareva, Gaukhar M. Dabylova, Anastasiya I. Demchenko, Oleg Yu. Dolgikh, Melis Y. Duyshobayev, Dmitrii S. Evdokimov, Ksenia E. Egorova, Anastasiia N. Ermilova, Aliya E. Zheldybayeva, Nataliya V. Zarechnova, Yuliia D. Zimina, Svetlana Yu. Ivanova, Elena Yu. Ivanchenko, Mariya V. Ilina, Maria V. Kazakovtseva, Elena V. Kazymova, Yuliya S. Kalinina, Nadezhda A. Kamardina, Anastasiya M. Karachenova, Igor A. Karetnikov, Nina A. Karoli, Magomed Kh. Karsiev, Daria S. Кaskaeva, Karina F. Kasymova, Zhainagul B. Kerimbekova, Ailar Sh. Kerimova, Eugeni S. Kim, Nina V. Kiseleva, Darya A. Klimenko, Anastasiia V. Klimova, Olga V. Kovalishena, Elena V. Kolmakova, Tatyana P. Kolchinskaya, Maria I. Kolyadich, Olga V. Kondriakova, Marina P. Konoval, Dmitryi Yu. Konstantinov, Elena A. Konstantinova, Vera A. Kordukova, Ekaterina V. Koroleva, Angelina Yu. Kraposhina, Tamara V. Kriukova, Alla S. Kuznetsova, Tatyana Yu. Kuzmina, Kirill V. Kuzmichev, Cholpon K. Kulchoroevna, Tatiana V. Kuprina, Irina M. Kouranova, Liliya V. Kurenkova, Natalia Yu. Kurchugina, Nadira A. Kushubakova, Valeriia I. Levankova, Natalia A. Lyubavina, Nadezhda A. Magdeyeva, Konstantin V. Mazalov, Viktoryia I. Majseenko, Aleksandra S. Makarova, Abdirashit M. Maripov, Anastasiia A. Marusina, Evgenii S. Melnikov, Nikita B. Moiseenko, Fazliniso N. Muradova, Rimma G. Muradyan, Shahane N. Musaelian, Anton O. Myshak, Ekaterina S. Nekaeva, Nataliia M. Nikitina, Bela B. Ogurlieva, Alla A. Odegova, Yuliia V. Omarova, Nazgul A. Omurzakova, Shynar O. Ospanova, Ekaterina V. Pahomova, Liviu D. Petrov, Svetlana S. Plastinina, Vera A. Pogrebetskaya, Dmitry S. Polyakov, Ekaterina V. Ponomarenko, Larisa L. Popova, Natalya A. Prokofeva, Inna A. Pudova, Nikita A. Rakov, Abdurakhmon N. Rahimov, Nadezhda A. Rozanova, Saltanat Serikbolkyzy, Andrei A Simonov, Valeriya V. Skachkova, Daria V. Soloveva, Irina A. Soloveva, Alexander K. Subbotin, Irina M. Sukhomlinova, Anastasiia G. Sushilova, Dilnoza R. Tagayeva, Yuliia V. Titojkina, Elena P. Tikhonova, Danil S. Tokmin, Anastasiia A. Tolmacheva, Mariya S. Torgunakova, Ksenia V. Trenogina, Natalia A. Trostianetckaia, Dmitriy A. Trofimov, Alexander A. Tulichev, Assiya T. Tursunova, Nina D. Ulanova, Oleg V. Fatenkov, Olga V. Fedorishina, Tatiana S. Fil, Irina Yu. Fomina, Irina S. Fominova, Irina A. Frolova, Svetlana M. Tsvinger, Vera V. Tsoma, Meerim B. Cholponbaeva, Tatiana I. Chudinovskikh, Olga A. Shevchenko, Tatyana V. Sheshina, Ekaterina A. Shishkina, Konstantin Yu. Shishkov, Stanislav Yu. Sherbakov, and Ekaterina A. Yausheva
Subjects: Adult, Male, Heart Failure, History, SARS-CoV-2, Endocrinology, Diabetes and Metabolism, COVID-19, Coronary Disease, General Medicine, Prognosis, Cardiovascular Diseases, Chronic Disease, Hypertension, Diabetes Mellitus, Humans, Female, Registries, Family Practice, Noncommunicable Diseases
Abstract: Study the impact of various combinations of comorbid original diseases in patients infected with COVID-19 later on the disease progression and outcomes of the new coronavirus infection.The ACTIV registry was created on the Eurasian Association of Therapists initiative. 5,808 patients have been included in the registry: men and women with COVID-19 treated at hospital or at home.gov ID NCT04492384.Most patients with COVID-19 have original comorbid diseases (oCDs). Polymorbidity assessed by way of simple counting of oCDs is an independent factor in negative outcomes of COVID-19. Search for most frequent combinations of 2, 3 and 4 oCDs has revealed absolute domination of cardiovascular diseases (all possible variants). The most unfavorable combination of 2 oCDs includes atrial hypertension (AH) and chronic heart failure (CHF). The most unfavorable combination of 3 oCDs includes AH, coronary heart disease (CHD) and CHF; the worst combination of 4 oCDs includes AH, CHD, CHF and diabetes mellitus. Such combinations increased the risk of lethal outcomes 3.963, 4.082 and 4.215 times respectively.Polymorbidity determined by way of simple counting of diseases may be estimated as a factor in the lethal outcome risk in the acute phase of COVID-19 in real practice. Most frequent combinations of 2, 3 and 4 diseases in patients with COVID-19 primarily include cardiovascular diseases (AH, CHD and CHF), diabetes mellitus and obesity. Combinations of such diseases increase the COVID-19 lethal outcome risk.Цель. Изучить влияние различных комбинаций сопутствующих заболеваний, существовавших у пациентов исходно, до инфицирования вирусом SARS-CoV-2, на тяжесть течения и исходы новой коронавирусной инфекции. Материалы и методы. Регистр АКТИВ создан по инициативе Евразийской ассоциации терапевтов. В регистр включены 5808 пациентов: мужчины и женщины с диагнозом COVID-19, находящиеся на лечении в стационаре или получающие лечение на дому. Регистрация регистра: идентификатор ClinicalTrials.gov: NCT04492384. Результаты. Подавляющее большинство пациентов с COVID-19 имеют исходные сопутствующие заболевания (иСЗ). Полиморбидность, оцененная методом простого подсчета иСЗ, является самостоятельным фактором негативного прогноза больных COVID-19. Поиск наиболее часто встречающихся комбинаций из 2, 3, 4 и более СЗ выявил абсолютное доминирование сердечно-сосудистых заболеваний во всех возможных вариантах. Наиболее неблагоприятной при сочетании 2 иСЗ была комбинация, включающая артериальную гипертензию (АГ) и хроническую сердечную недостаточность (ХСН), при сочетании 3 иСЗ комбинация, включающая АГ, ишемическую болезнь сердца (ИБС), ХСН, и при сочетании 4 иСЗ комбинация, включающая АГ, ИБС, ХСН и сахарный диабет. Наличие таких комбинаций приводило к росту риска летального исхода в 3,963, 4,082, 4,215 раза соответственно. Заключение. Полиморбидность, определенная методом простого подсчета заболеваний, может использоваться в реальной практике как фактор риска летальности в остром периоде COVID-19. В состав наиболее часто встречающихся комбинаций из 2, 3, 4 заболеваний у пациентов с COVID-19 входят преимущественно сердечно-сосудистые заболевания (АГ, ИБС, ХСН), сахарный диабет и ожирение. Комбинации этих заболеваний повышают риск летального исхода при COVID-19.
Published: 2021

26. Analysis of influence of background therapy for comorbidities in the period before infection on the risk of the lethal COVID outcome. Data from the international ACTIV SARS-CoV-2 registry («Analysis of chronic non-infectious diseases dynamics after COVID-19 infection in adult patients SARS-CoV-2»)

Author: N V Lareva, A Sh Kerimova, D A Shсukarev, I. V. Fomin, I. A. Karetnikov, K. F. Kasymova, U. K. Kamilova, A. M. Budu, A O Konradi, A. A. Marusina, V. I. Majseenko, Yu D Zimina, E. V. Ponomarenko, E. V. Grigorieva, N. V. Bakulina, I. G. Pochinka, O. V. Kondriakova, N. A. Lyubavina, A. G. Sushilova, K. V. Protasov, E A Konstantinova, Yu. M. Lopatin, I I Shaposhnik, O. V. Karpov, I. A. Soloveva, N. V. Zarechnova, M. V. Bragin, G. T. Aimakhanova, O Yu Badina, O Yu Chizhova, A. P. Rebrov, D. V. Soloveva, E S Kim, V. I. Levankova, S. V. Malchikova, A. S. Galyavich, I. M. Sukhomlinova, M. B. Cholponbaeva, A. V. Klimova, A. R. Vaisberg, M. P. Konoval, V. V. Skachkova, N. N. Vezikova, E. A. Gаlova, N. A. Prokofeva, M Е Levin, L. A. Balykova, M. V. Kazakovtseva, A. S. Makarova, T. I. Chudinovskikh, K R Vagapova, A. K. Subbotin, N Yu Kurchugina, A. T. Tursunova, L. D. Petrov, O. R. Aruslanova, M V Ilina, Yu N Belenkov, I. V. Gubareva, E. S. Melnikov, G. A. Bykova, S Yu Ivanova, Yu V Titojkina, Z. F. Kim, A. V. Aparkina, D Yu Konstantinov, A. M. Maripov, K. V. Trenogina, Ch K. Kulchoroeva, E. A. Yausheva, S. S. Plastinina, N. D. Ulanova, D. D. Varlamova, E. V. Makarova, S. V. Nedogoda, R. V. Gostishev, A. P. Babin, A S Sarybaev, S. A. Avetisian, M. S. Torgunakova, G P Arutyunov, O. V. Fedorishina, L. V. Kurenkova, Sh O. Ospanova, G M Dabylova, E. I. Gorshenina, V V Genkel, N. M. Nikitina, M Kh Karsiev, R. G. Muradyan, M. V. Boldina, S Yu Sherbakov, A. A. Odegova, E. P. Tikhonova, M. I. Kolyadich, D. N. Protsenko, V. V. Gomonova, N. A. Karoli, T. V. Kuprina, N. B. Moiseenko, A O Myshak, K Yu Shishkov, N Yu Grigorieva, K. E. Egorova, A. N. Rakhimov, V. A. Pogrebetskaya, S. N. Tereshchenko, V. V. Vustina, I. U. Bikhteyev, N. A. Magdeyeva, Sh N. Musaelian, A. A. Tulichev, O. V. Khlynova, E. V. Kolmakova, A. I. Demchenko, E. V. Pahomova, I. A. Frolova, D. A. Trofimov, M. Y. Duyshobayev, A I Chesnikova, T. S. Fil, A. S. Kuznetsova, N. A. Kamardina, K. V. Kuzmichev, I. V. Demko, D. A. Klimenko, D. S. Evdokimov, O. E. Vilkova, K. V. Mazalov, A Ch Akunov, A. N. Ermilova, N. A. Rakov, B. B. Ogurlieva, O. V. Fatenkov, O. A. Shevchenko, A A Tolmacheva, E Yu Ashina, E. A. Vinnikova, D Yu Ruzanau, Zh B. Kerimbekova, A. K. Abdrahmanova, Yu S. Kalinina, T. V. Sheshina, I. G. Bakulin, Yu M. Omarova, A. V. Zharkov, I S Fominova, H. G. Hayrapetyan, L. A. Burygina, N. V. Kiseleva, A. M. Karachenova, A. M. Bitieva, D. S. Polyakov, T V Kriukova, F. M. Sokhova, A. G. Arutyunov, D. A. Ayipova, M. M. Petrova, M K Alieva, N. A. Borodulina, F. N. Muradova, I. A. Pudova, N A Kushubakova, A. A. Simonov, V. V. Tsoma, S. Serikbolkyzy, O Yu Barisheva, E. A. Shishkina, O. V. Kovalishena, L. L. Popova, A. V. Evzerikhina, A S Batchayeva, T Yu Kuzmina, K. K. Azarian, D. S. Tokmin, N. A. Omurzakova, D S Кaskaeva, A. E. Zheldybayeva, T. Yu. Kuznetsova, I Yu Fomina, E. A. Verbitskaya, N. A. Rozanova, D. R. Tagayeva, S. M. Tsvinger, E. Yu. Ivanchenko, S A Sayganov, N. A. Trostianetckaia, A. S. Blagonravova, A. Yu. Kraposhina, V. A. Kordukova, E. I. Tarlovskaya, O Yu Dolgikh, I. M. Kouranova, H. G. Avoyan, E. V. Kazymova, T. P. Kolchinskaya, N M Selezneva, A. B. Sugraliev, E. V. Koroleva, and E Yu Gubareva
Subjects: Adult, Male, medicine.medical_specialty, Population, Disease, Comorbidity, Lower risk, Pharmacotherapy, Internal medicine, medicine, Humans, Registries, education, Noncommunicable Diseases, Pandemics, education.field_of_study, COPD, business.industry, SARS-CoV-2, COVID-19, medicine.disease, Clopidogrel, Diabetes Mellitus, Type 2, Female, Cardiology and Cardiovascular Medicine, business, Ticagrelor, medicine.drug
Abstract: Aim To study the effect of regular drug therapy for cardiovascular and other diseases preceding the COVID-19 infection on severity and outcome of COVID-19 based on data of the ACTIVE (Analysis of dynamics of Comorbidities in paTIents who surVived SARS-CoV-2 infEction) registry.Material and methods The ACTIVE registry was created at the initiative of the Eurasian Association of Therapists. The registry includes 5 808 male and female patients diagnosed with COVID-19 treated in a hospital or at home with a due protection of patients’ privacy (data of nasal and throat smears; antibody titer; typical CT imaging features). The register territory included 7 countries: the Russian Federation, the Republic of Armenia, the Republic of Belarus, the Republic of Kazakhstan, the Kyrgyz Republic, the Republic of Moldova, and the Republic of Uzbekistan. The registry design: a closed, multicenter registry with two nonoverlapping arms (outpatient arm and in-patient arm). The registry scheduled 6 visits, 3 in-person visits during the acute period and 3 virtual visits (telephone calls) at 3, 6, and 12 mos. Patient enrollment started on June 29, 2020 and was completed on October 29, 2020. The registry completion is scheduled for October 29, 2022. The registry ID: ClinicalTrials.gov: NCT04492384. In this fragment of the study of registry data, the work group analyzed the effect of therapy for comorbidities at baseline on severity and outcomes of the novel coronavirus infection. The study population included only the patients who took their medicines on a regular basis while the comparison population consisted of noncompliant patients (irregular drug intake or not taking drugs at all despite indications for the treatment).ResultsThe analysis of the ACTIVE registry database included 5808 patients. The vast majority of patients with COVID-19 had comorbidities with prevalence of cardiovascular diseases. Medicines used for the treatment of COVID-19 comorbidities influenced the course of the infectious disease in different ways. A lower risk of fatal outcome was associated with the statin treatment in patients with ischemic heart disease (IHD); with angiotensin-converting enzyme inhibitors (ACEI)/angiotensin receptor antagonists and with beta-blockers in patients with IHD, arterial hypertension, chronic heart failure (CHF), and atrial fibrillation; with oral anticoagulants (OAC), primarily direct OAC, clopidogrel/prasugrel/ticagrelor in patients with IHD; with oral antihyperglycemic therapy in patients with type 2 diabetes mellitus (DM); and with long-acting insulins in patients with type 1 DM. A higher risk of fatal outcome was associated with the spironolactone treatment in patients with CHF and with inhaled corticosteroids (iCS) in patients with chronic obstructive pulmonary disease (COPD).Conclusion In the epoch of COVID-19 pandemic, a lower risk of severe course of the coronavirus infection was observed for patients with chronic noninfectious comorbidities highly compliant with the base treatment of the comorbidity.
Published: 2021

27. Analysis of influence of background therapy for comorbidities in the period before infection on the risk of the lethal COVID outcome. Data from the international ACTIV SARS-CoV-2 registry («Analysis of chronic non-infectious diseases dynamics after COVID-19 infection in adult patients SARS-CoV-2»)

Author: Tarlovskaya, E. I., primary, Arutyunov, A. G., additional, Konradi, A. O., additional, Lopatin, Yu. M., additional, Rebrov, A. P., additional, Tereshchenko, S. N., additional, Chesnikova, A. I., additional, Hayrapetyan, H. G., additional, Babin, A. P., additional, Bakulin, I. G., additional, Bakulina, N. V., additional, Balykova, L. A., additional, Blagonravova, A. S., additional, Boldina, M. V., additional, Vaisberg, A. R., additional, Galyavich, A. S., additional, Gomonova, V. V., additional, Grigorieva, N. Yu., additional, Gubareva, I. V., additional, Demko, I. V., additional, Evzerikhina, A. V., additional, Zharkov, A. V., additional, Kamilova, U. K., additional, Kim, Z. F., additional, Kuznetsova, T. Yu., additional, Lareva, N. V., additional, Makarova, E. V., additional, Malchikova, S. V., additional, Nedogoda, S. V., additional, Petrova, M. M., additional, Pochinka, I. G., additional, Protasov, K. V., additional, Protsenko, D. N., additional, Ruzanau, D. Yu., additional, Sayganov, S. A., additional, Sarybaev, A. S., additional, Selezneva, N. M., additional, Sugraliev, A. B., additional, Fomin, I. V., additional, Khlynova, O. V., additional, Chizhova, O. Yu., additional, Shaposhnik, I. I., additional, Shсukarev, D. A., additional, Abdrahmanova, A. K., additional, Avetisian, S. A., additional, Avoyan, H. G., additional, Azarian, K. K., additional, Aimakhanova, G. T., additional, Ayipova, D. A., additional, Akunov, A. Ch., additional, Alieva, M. K., additional, Aparkina, A. V., additional, Aruslanova, O. R., additional, Ashina, E. Yu., additional, Badina, O. Yu., additional, Barisheva, O. Yu., additional, Batchayeva, A. S., additional, Bitieva, A. M., additional, Bikhteyev, I. U., additional, Borodulina, N. A., additional, Bragin, M. V., additional, Budu, A. M., additional, Burygina, L. A., additional, Bykova, G. A., additional, Vagapova, K. R., additional, Varlamova, D. D., additional, Vezikova, N. N., additional, Verbitskaya, E. A., additional, Vilkova, O. E., additional, Vinnikova, E. A., additional, Vustina, V. V., additional, Gаlova, E. A., additional, Genkel, V. V., additional, Gorshenina, E. I., additional, Gostishev, R. V., additional, Grigorieva, E. V., additional, Gubareva, E. Yu., additional, Dabylova, G. M., additional, Demchenko, A. I., additional, Dolgikh, O. Yu., additional, Duyshobayev, M. Y., additional, Evdokimov, D. S., additional, Egorova, K. E., additional, Ermilova, A. N., additional, Zheldybayeva, A. E., additional, Zarechnova, N. V., additional, Zimina, Yu. D., additional, Ivanova, S. Yu., additional, Ivanchenko, E. Yu., additional, Ilina, M. V., additional, Kazakovtseva, M. V., additional, Kazymova, E. V., additional, Kalinina, Yu. S., additional, Kamardina, N. A., additional, Karachenova, A. M., additional, Karetnikov, I. A., additional, Karoli, N. A., additional, Karpov, O. V., additional, Karsiev, M. Kh., additional, Кaskaeva, D. S., additional, Kasymova, K. F., additional, Kerimbekova, Zh. B., additional, Kerimova, A. Sh., additional, Kim, E. S., additional, Kiseleva, N. V., additional, Klimenko, D. A., additional, Klimova, A. V., additional, Kovalishena, O. V., additional, Kolmakova, E. V., additional, Kolchinskaya, T. P., additional, Kolyadich, M. I., additional, Kondriakova, O. V., additional, Konoval , M. P., additional, Konstantinov, D. Yu., additional, Konstantinova, E. A., additional, Kordukova, V. A., additional, Koroleva, E. V., additional, Kraposhina, A. Yu., additional, Kriukova, T. V., additional, Kuznetsova, A. S., additional, Kuzmina, T. Yu., additional, Kuzmichev, K. V., additional, Kulchoroeva, Ch. K., additional, Kuprina, T. V., additional, Kouranova, I. M., additional, Kurenkova, L. V., additional, Kurchugina, N. Yu., additional, Kushubakova, N. A., additional, Levankova, V. I., additional, Levin, M. Е., additional, Lyubavina, N. A., additional, Magdeyeva, N. A., additional, Mazalov, K. V., additional, Majseenko, V. I., additional, Makarova, A. S., additional, Maripov, A. M., additional, Marusina, A. A., additional, Melnikov, E. S., additional, Moiseenko, N. B., additional, Muradova, F. N., additional, Muradyan, R. G., additional, Myshak, A. O., additional, Nikitina, N. M., additional, Ogurlieva, B. B., additional, Odegova, A. A., additional, Omarova, Yu. M., additional, Omurzakova, N. A., additional, Ospanova, Sh. O., additional, Pahomova, E. V., additional, Petrov, L. D., additional, Plastinina, S. S., additional, Pogrebetskaya, V. A., additional, Polyakov, D. S., additional, Ponomarenko, E. V., additional, Popova, L. L., additional, Prokofeva, N. A., additional, Pudova, I. A., additional, Rakov, N. A., additional, Rakhimov, A. N., additional, Rozanova, N. A., additional, Serikbolkyzy, S., additional, Simonov, A. A., additional, Skachkova, V. V., additional, Soloveva, D. V., additional, Soloveva, I. A., additional, Sokhova, F. M., additional, Subbotin, A. K., additional, Sukhomlinova, I. M., additional, Sushilova, A. G., additional, Tagayeva, D. R., additional, Titojkina, Yu. V., additional, Tikhonova, E. P., additional, Tokmin, D. S., additional, Tolmacheva, A. A., additional, Torgunakova, M. S., additional, Trenogina, K. V., additional, Trostianetckaia, N. A., additional, Trofimov, D. A., additional, Tulichev, A. A., additional, Tursunova, A. T., additional, Ulanova, N. D., additional, Fatenkov, O. V., additional, Fedorishina, O. V., additional, Fil, T. S., additional, Fomina, I. Yu., additional, Fominova, I. S., additional, Frolova, I. A., additional, Tsvinger, S. M., additional, Tsoma, V. V., additional, Cholponbaeva, M. B., additional, Chudinovskikh, T. I., additional, Shevchenko, O. A., additional, Sheshina, T. V., additional, Shishkina, E. A., additional, Shishkov, K. Yu., additional, Sherbakov, S. Yu., additional, Yausheva, E. A., additional, Musaelian, Sh. N., additional, Belenkov, Yu. N., additional, and Arutyunov, G. P., additional
Published: 2021
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28. Analysis of the upper respiratory tract microbiota in mild and severe COVID-19 patients

Author: Babenko, V., primary, Bakhtyev, R., additional, Baklaushev, V., additional, Balykova, L., additional, Bashkirov, P., additional, Bespyatykh, J., additional, Blagonravova, A., additional, Boldyreva, D., additional, Fedorov, D., additional, Gafurov, I., additional, Gaifullina, R., additional, Galeeva, J., additional, Galova, E., additional, Gospodaryk, A., additional, Ilina, E., additional, Ivanov, K., additional, Kharlampieva, D., additional, Khromova, P., additional, Klimina, K., additional, Kolontarev, K., additional, Kolyshkina, N., additional, Koritsky, A., additional, Kuropatkin, V., additional, Lazarev, V., additional, Manolov, A., additional, Manuvera, V., additional, Matyushkina, D., additional, Morozov, M., additional, Moskaleva, E., additional, Musarova, V., additional, Ogarkov, O., additional, Orlova, E., additional, Pavlenko, A., additional, Petrova, A., additional, Pozhenko, N., additional, Pushkar, D., additional, Rumyantsev, A., additional, Rumyantsev, S., additional, Rumyantsev, V., additional, Rychkova, L., additional, Samoilov, A., additional, Shirokova, I., additional, Sinkov, V., additional, Solovieva, S., additional, Starikova, E., additional, Tikhonova, P., additional, Trifonova, G., additional, Troitsky, A., additional, Tulichev, A., additional, Udalov, Y., additional, Varizhuk, A., additional, Vasiliev, A., additional, Vereshchagin, R., additional, Veselovsky, V., additional, Volnukhin, A., additional, Yusubalieva, G., additional, and Govorun, V., additional
Published: 2021
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29. ADAPTIVE PHYSICAL EDUCATION IN PATIENTS WITH CARDIOVASCULAR DISEASES

Author: V.A. Vyaznikova, I.B. Ulitin, V.G. Kuzmin, A.A. Tulichev, N.Y. Fyodorova, and A.N. Ovchinnikov
Subjects: medicine.medical_specialty, business.industry, Physical therapy, Medicine, In patient, business, Physical education
Published: 2020

30. Daily indices of central and peripheral blood pressure in patients with chronic glomerulonephritis and arterial hypertension at different stages of chronic kidney disease

Author: A A Tulichev, T I Maslova, S Yu Zubova, N Yu Borovkova, I V Polyakova, N Yu Linyova, and I Yu Maksimova
Subjects: medicine.medical_specialty, arterial hypertension, 030232 urology & nephrology, Diastole, Renal function, lcsh:Medicine, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine.artery, medicine, Brachial artery, Aorta, biology, Dipper, business.industry, lcsh:R, General Medicine, biology.organism_classification, medicine.disease, Pulse pressure, chronic glomerulonephritis, Blood pressure, Cardiology, business, central and peripheral blood pressure, chronic kidney disease, Kidney disease
Abstract: Aim. To study the daily indices of central and peripheral blood pressure in patients with chronic glomerulonephritis and arterial hypertension at different stages of chronic kidney disease. Methods. 76 patients with chronic glomerulonephritis and arterial hypertension were examined: 13.2% with chronic kidney disease stage 1 (G1), 15.8% G2, 21.0% G3, 23.7% G4, 26.3% G5D. For the daily monitoring of central (in aorta) and peripheral blood pressure (in brachial artery), the BPLab monitor and the Vasotens-24 technology were used. Results. In the examined patients central and peripheral systolic, diastolic, and pulse blood pressure increased with renal function decline. Thus, the daily systolic pressure increased from 112 [107; 129] mm Hg in the aorta and 127 [118; 131] mm Hg in the brachial artery in patients with G1 to 146 [137; 153] and 147 [138; 155] mm Hg with G5D; diastolic — from 76 [70; 83] and 78 [71; 85] to 96 [82; 104] and 97 [81; 107] mm Hg; pulse pressure — from 36 [33; 45] and 48 [42; 51] to 53 [45; 56] and 62 [50; 65] mm Hg (p
Published: 2019

31. Endothelial function and its role in the formation of cardiovascular pathology in patients with rheumatoid arthritis

Author: I Yu Maksimova, N Yu Borovkova, N. N. Borovkov, I V Polyakova, A. A. Spassky, A A Tulichev, and S Yu Zubova
Subjects: rheumatoid arthritis, musculoskeletal diseases, Cardiovascular pathology, lcsh:Medicine, Disease, 030204 cardiovascular system & hematology, Systemic inflammation, endothelial dysfunction, 03 medical and health sciences, 0302 clinical medicine, Immune system, medicine, In patient, Endothelial dysfunction, skin and connective tissue diseases, Subclinical infection, 030203 arthritis & rheumatology, business.industry, lcsh:R, General Medicine, medicine.disease, Rheumatoid arthritis, Immunology, atherosclerosis, medicine.symptom, business
Abstract: Currently rheumatoid arthritis is considered as an immune inflammatory disease of unknown origin characterized by chronic erosive arthritis and systemic damage of internal organs, leading to early disability and reduced life expectancy. Cardiovascular diseases are most often mentioned as factors of poor prognosis in rheumatoid arthritis. Pathology of the cardiovascular system in rheumatoid arthritis is usually associated with the macro- and microvascular changes and rheumatoid lesions of the heart. The leading factor in the damage of the vascular wall in rheumatoid arthritis is systemic inflammation affecting its viscosity and elastic properties, increased rigidity, impaired endothelial function. Endothelial dysfunction is currently regarded to as an initial stage of morphogenesis of various vascular disorders. It is considered as a subclinical marker of cardiovascular diseases and the earliest predictor of cardiovascular complications. From this point of view study of endothelial dysfunction in patients with rheumatoid arthritis aimed at determining cardiovascular risk is a perspective direction. Only single and fragmentary information about certain endothelial functions in patients with rheumatoid arthritis and substances released in this. There is no clear analysis of relationship between them and dependence on the process activity. Not clear is their role in the pathology of the vascular wall in rheumatoid arthritis. This literature review discusses the problem of endothelial dysfunction in rheumatoid arthritis patients as well as its role in the development of cardiovascular diseases in these patients. The development mechanisms and the role of immune inflammation in its formation are considered. Also the association was found between chronic inflammatory activity indicators in rheumatoid arthritis and various biological markers and development of endothelial dysfunction. The effects of antirheumatic treatment on endothelial dysfunction in these patients were analyzed.
Published: 2019

32. ARTERIAL STIFFNESS IN PATIENTS WITH RHEUMATOID ARTHRITIS WITH ARTERIAL HYPERTENSION AND THE POTENTIALS FOR ITS CORRECTION (LITERATURE REVIEW)

Author: A.A. Tulichev Tulichev, S Yu Zubova, A.A. Spassky Spassky, N. Yu. Borovkova, A.S. Ilyina Ilyina, I Yu Maksimova, and N.F. Kiseleva Kiseleva
Subjects: medicine.medical_specialty, business.industry, Internal medicine, Rheumatoid arthritis, medicine, Arterial stiffness, Cardiology, In patient, medicine.disease, business
Published: 2018

33. [International register 'Analysis of Chronic Non-infectious Diseases Dynamics After COVID-19 Infection in Adult Patients (ACTIV SARS-CoV-2)']

Author: V. V. Tsoma, N A Krivosheina, M S Grigorovich, D. R. Tagayeva, D Y Ruzanau, A. M. Budu, A O Konradi, I Y Fomina, E. V. Kazymova, O. V. Kondriakova, I I Shaposhnik, M D Gaukhar, E. V. Grigorieva, N. N. Vezikova, I A Duvanov, I. A. Pudova, N. A. Prokofeva, G. T. Aimakhanova, D. A. Trofimov, E. S. Melnikov, L. D. Shakhgildyan, T. I. Chudinovskikh, M. V. Kazakovtseva, A. T. Tursunova, A. K. Abdrahmanova, A. B. Sugraliev, E. V. Koroleva, A. P. Rebrov, D. S. Evdokimov, S V Baramzina, E. P. Tikhonova, N. A. Magdeyeva, Y N Belenkov, T. Y. Kuzmina, A A Levchenko, L. A. Burygina, S T Fil, A S Kerimova, I. M. Kouranova, A. R. Vaisberg, M. P. Konoval, Z. F. Kim, A. V. Aparkina, A. A. Tulichev, D. S. Tokmin, I. V. Fomin, S. N. Tereshchenko, N. U. Grigorieva, D V Saphonov, N. A. Kamardina, R. V. Gostishev, U. K. Kamilova, L. A. Smirnova, O A Chumakova, H. G. Avoyan, N A Kushubakova, K. V. Mazalov, A. N. Ermilova, V V Genkel, N. A. Lyubavina, A E Gаlova, O. V. Fatenkov, Y M Lopatin, V. V. Gomonova, H. G. Hayrapetyan, N. V. Zarechnova, E S Kim, Z D Rasulova, N Y Kurchugina, S A Sayganov, N. M. Nikitina, T. V. Sheshina, G P Arutyunov, V. I. Levankova, S. V. Malchikova, A. A. Simonov, T. V. Kuprina, E Y Ashina, S. S. Plastinina, A S Sarybaev, N. A. Trostianetckaia, I. A. Frolova, S. V. Nedogoda, S. Serikbolkyzy, F. N. Muradova, M. B. Cholponbaeva, A. V. Evzerikhina, N. A. Rozanova, T Y Kuznetsova, A. S. Galyavich, A. A. Odegova, A C Akunov, D. I. Tupitsin, Y V Omarova, A. S. Blagonravova, A. K. Subbotin, O Y Barisheva, N. V. Kiseleva, A. V. Klimova, Sh O. Ospanova, M. E. Levin, M. Y. Duyshobayev, O. V. Kovalishena, V M Boldina, E. V. Makarova, Zh B. Kerimbekova, E Y Gubareva, D. V. Soloveva, D. N. Protsenko, N. A. Karoli, K. E. Egorova, A Y Kraposhina, V. A. Pogrebetskaya, K. K. Azarian, E. V. Pahomova, N V Zelyaeva, D. A. Ayipova, S. A. Avetisian, O Y Badina, R. G. Muradyan, I. V. Demko, V. A. Kordukova, E. I. Tarlovskaya, D Y Konstantinov, M. I. Kolyadich, A. E. Zheldybayeva, A. P. Babin, Sh N. Musaelian, D S Kaskaeva, S Y Chukhlova, K Y Shishkov, T. P. Kolchinskaya, T V Kriukova, I. V. Gubareva, O Y Dolgikh, V. I. Majseenko, O. V. Karpov, I. A. Soloveva, S Y Sherbakov, A. M. Bitieva, D. S. Polyakov, E M Mamutova, F. M. Sokhova, A. G. Arutyunov, L. D. Petrov, M. M. Petrova, S Y Ivanova, D. D. Varlamova, A. A. Tiurin, D A Doshchannikov, A. I. Demchenko, A I Chesnikova, A. S. Kuznetsova, D. A. Klimenko, and O. E. Vilkova
Subjects: Adult, 2019-20 coronavirus outbreak, Adult patients, Coronavirus disease 2019 (COVID-19), business.industry, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), MEDLINE, COVID-19, Virology, Medicine, Humans, Cardiology and Cardiovascular Medicine, business, Noncommunicable Diseases, Non infectious
Published: 2021

34. Immunological Approaches to the Treatment of Novel Coronavirus Infection (Review)

Author: Lyubavina, N.A., primary, Saltsev, S.G., additional, Menkov, N.V., additional, Tyurikova, L.V., additional, Plastinina, S.S., additional, Shonia, M.L., additional, Tulichev, A.A., additional, Milyutina, M.Yu., additional, and Makarova, E.V., additional
Published: 2021
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35. International register “Dynamics analysis of comorbidities in SARS-CoV-2 survivors” (AKTIV SARS-CoV-2): analysis of predictors of short-term adverse outcomes in COVID-19

Author: Arutyunov, G. P., primary, Tarlovskaya, E. I., additional, Arutyunov, A. G., additional, Belenkov, Y. N., additional, Konradi, A. O., additional, Lopatin, Y. M., additional, Rebrov, A. P., additional, Tereshchenko, S. N., additional, Chesnikova, A. I., additional, Hayrapetyan, H. G., additional, Babin, A. P., additional, Bakulin, I. G., additional, Bakulina, N. V., additional, Balykova, L. A., additional, Blagonravova, A. S., additional, Boldina, M. V., additional, Vaisberg, A. R., additional, Galyavich, A. S., additional, Gomonova, V. V., additional, Grigorieva, N. U., additional, Gubareva, I. V., additional, Demko, I. V., additional, Evzerikhina, A. V., additional, Zharkov, A. V., additional, Kamilova, U. K., additional, Kim, Z. F., additional, Kuznetsova, T. Yu., additional, Lareva, N. V., additional, Makarova, E. V., additional, Malchikova, S. V., additional, Nedogoda, S. V., additional, Petrova, M. M., additional, Pochinka, I. G., additional, Protasov, K. V., additional, Protsenko, D. N., additional, Ruzanov, D. Yu., additional, Sayganov, S. A., additional, Sarybaev, A. Sh., additional, Selezneva, N. M., additional, Sugraliev, A. B., additional, Fomin, I. V., additional, Khlynova, O. V., additional, Chizhova, O. Yu., additional, Shaposhnik, I. I., additional, Schukarev, D. A., additional, Abdrahmanova, A. K., additional, Avetisian, S. A., additional, Avoyan, H. G., additional, Azarian, K. K., additional, Aimakhanova, G. T., additional, Ayipova, D. A., additional, Akunov, A. Ch., additional, Alieva, M. K., additional, Aparkina, A. V., additional, Aruslanova, O. R., additional, Ashina, E. Yu., additional, Badina, O. Y., additional, Barisheva, O. Yu., additional, Batchayeva, A. S., additional, Bikhteyev, I. U., additional, Borodulina, N. A., additional, Bragin, M. V., additional, Budu, A. M., additional, Burygina, L. A., additional, Bykova, G. A., additional, Varlamova, D. D., additional, Vezikova, N. N., additional, Verbitskaya, E. A., additional, Vilkova, O. E., additional, Vinnikova, E. A., additional, Vustina, V. V., additional, Gаlova, E. A., additional, Genkel, V. V., additional, Gorshenina, E. I., additional, Gostishev, R. V., additional, Grigorieva, E. V., additional, Gubareva, E. Yu., additional, Dabylova, G. M., additional, Demchenko, A. I., additional, Dolgikh, O. Yu., additional, Duvanov, I. A., additional, Duyshobayev, M. Y., additional, Evdokimov, D. S., additional, Egorova, K. E., additional, Ermilova, A. N., additional, Zheldybayeva, A. E., additional, Zarechnova, N. V., additional, Ivanova, S. Yu., additional, Ivanchenko, E. Yu., additional, Ilina, M. V., additional, Kazakovtseva, M. V., additional, Kazymova, E. V., additional, Kalinina, Yu. S., additional, Kamardina, N. A., additional, Karachenova, A. M., additional, Karetnikov, I. A., additional, Karoli, N. A., additional, Karpov, O. V., additional, Karsiev, M. Kh., additional, Kaskaeva, D. S., additional, Kasymova, K. F., additional, Kerimbekova, Zh. B., additional, Kerimova, A. Sh., additional, Kim, E. S., additional, Kiseleva, N. V., additional, Klimenko, D. A., additional, Klimova, A. V., additional, Kovalishena, O. V., additional, Kolmakova, E. V., additional, Kolchinskaya, T. P., additional, Kolyadich, M. I., additional, Kondriakova, O. V., additional, Konoval, M. P., additional, Konstantinov, D. Yu., additional, Konstantinova, E. A., additional, Kordukova, V. A., additional, Koroleva, E. V., additional, Kraposhina, A. Yu., additional, Kriukova, T. V., additional, Kuznetsova, A. S., additional, Kuzmina, T. Y., additional, Kuzmichev, K. V., additional, Kulchoroeva, Ch. K., additional, Kuprina, T. V., additional, Kouranova, I. V., additional, Kurenkova, L. V., additional, Kurchugina, N. Yu., additional, Kushubakova, N. A., additional, Levankova, V. I., additional, Levin, M. E., additional, Lyubavina, N. A., additional, Magdeyeva, N. A., additional, Mazalov, K. V., additional, Majseenko, V. I., additional, Makarova, A. S., additional, Maripov, A. M., additional, Marusina, A. A., additional, Melnikov, E. S., additional, Moiseenko, N. B., additional, Muradova, F. N., additional, Muradyan, R. G., additional, Musaelian, Sh. N., additional, Nikitina, N. M., additional, Ogurlieva, B. B., additional, Odegova, A. A., additional, Omarova, Yu. M., additional, Omurzakova, N. A., additional, Ospanova, Sh. O., additional, Pahomova, E. V., additional, Petrov, L. D., additional, Plastinina, S. S., additional, Pogrebetskaya, V. A., additional, Polyakov, D. S., additional, Ponomarenko, E. V., additional, Popova, L. L., additional, Prokofeva, N. A., additional, Pudova, I. A., additional, Rakov, N. A., additional, Rakhimov, A. N., additional, Rozanova, N. A., additional, Serikbolkyzy, S., additional, Simonov, A. A., additional, Skachkova, V. V., additional, Smirnova, L. A., additional, Soloveva, D. V., additional, Soloveva, I. A., additional, Sokhova, F. M., additional, Subbotin, A. K., additional, Sukhomlinova, I. M., additional, Sushilova, A. G., additional, Tagayeva, D. R., additional, Titojkina, Yu. V., additional, Tikhonova, E. P., additional, Tokmin, D. S., additional, Torgunakova, M. S., additional, Trenogina, K. V., additional, Trostianetckaia, N. A., additional, Trofimov, D. A., additional, Tulichev, A. A., additional, Tupitsin, D. I., additional, Tursunova, A. T., additional, Ulanova, N. D., additional, Fatenkov, O. V., additional, Fedorishina, O. V., additional, Fil, T. S., additional, Fomina, I. Yu., additional, Fominova, I. S., additional, Frolova, I. A., additional, Tsvinger, S. M., additional, Tsoma, V. V., additional, Cholponbaeva, M. B., additional, Chudinovskikh, T. I., additional, Shakhgildyan, L. D., additional, Shevchenko, O. A., additional, Sheshina, T. V., additional, Shishkina, E. A., additional, Shishkov, K. Yu., additional, Sherbakov, S. Y., additional, and Yausheva, E. A., additional
Published: 2021
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36. International register “Dynamics analysis of comorbidities in SARS-CoV-2 survivors” (AKTIV) and the register “Analysis of hospitalizations of comorbid patients infected during the second wave of SARS-CoV-2 outbreak” (AKTIV 2)

Author: Arutyunov, G. P., primary, Tarlovskaya, E. I., additional, Arutyunov, A. G., additional, Belenkov, Y. N., additional, Konradi, A. O., additional, Lopatin, Y. M., additional, Rebrov, A. P., additional, Tereshchenko, S. N., additional, Chesnikova, A. I., additional, Hayrapetyan, H. G., additional, Babin, A. P., additional, Bakulin, I. G., additional, Bakulina, N. V., additional, Balykova, L. A., additional, Blagonravova, A. S., additional, Boldina, M. V., additional, Vaisberg, A. R., additional, Galyavich, A. S., additional, Gomonova, V. V., additional, Grigorieva, N. U., additional, Gubareva, I. V., additional, Demko, I. V., additional, Evzerikhina, A. V., additional, Zharkov, A. V., additional, Kamilova, U. K., additional, Kim, Z. F., additional, Kuznetsova, T. Yu., additional, Lareva, N. V., additional, Makarova, E. V., additional, Malchikova, S. V., additional, Nedogoda, S. V., additional, Petrova, M. M., additional, Pochinka, I. G., additional, Protasov, K. V., additional, Protsenko, D. N., additional, Ruzanov, D. Yu., additional, Sayganov, S. A., additional, Sarybaev, A. Sh., additional, Selezneva, N. M., additional, Sugraliev, A. B., additional, Fomin, I. V., additional, Khlynova, O. V., additional, Chizhova, O. Yu., additional, Shaposhnik, I. I., additional, Sсhukarev, D. A., additional, Abdrahmanova, A. K., additional, Avetisian, S. A., additional, Avoyan, H. G., additional, Azarian, K. K., additional, Aimakhanova, G. T., additional, Ayipova, D. A., additional, Akunov, A. Ch., additional, Alieva, M. K., additional, Aparkina, A. V., additional, Aruslanova, O. R., additional, Ashina, E. Yu., additional, Badina, O. Y., additional, Barisheva, O. Yu., additional, Batchayeva, A. S., additional, Bitieva, A. M., additional, Bikhteyev, I. U., additional, Borodulina, N. A., additional, Bragin, M. V., additional, Budu, A. M., additional, Burygina, L. A., additional, Bykova, G. A., additional, Varlamova, D. D., additional, Vezikova, N. N., additional, Verbitskaya, E. A., additional, Vilkova, O. E., additional, Vinnikova, E. A., additional, Vustina, V. V., additional, Gаlova, E. A., additional, Genkel, V. V., additional, Gorshenina, E. I., additional, Grigorieva, E. V., additional, Gubareva, E. Yu., additional, Dabylova, G. M., additional, Demchenko, A. I., additional, Dolgikh, O. Yu., additional, Duvanov, I. A., additional, Duyshobayev, M. Y., additional, Evdokimov, D. S., additional, Egorova, K. E., additional, Ermilova, A. N., additional, Zheldybayeva, A. E., additional, Zarechnova, N. V., additional, Ivanova, S. Yu., additional, Ivanchenko, E. Yu., additional, Ilina, M. V., additional, Kazakovtseva, M. V., additional, Kazymova, E. V., additional, Kalinina, Yu. S., additional, Kamardina, N. A., additional, Karachenova, A. M., additional, Karetnikov, I. A., additional, Karoli, N. A., additional, Karpov, O. V., additional, Karsiev, M. Kh., additional, Кaskaeva, D. S., additional, Kasymova, K. F., additional, Kerimbekova, Zh. B., additional, Kerimova, A. Sh., additional, Kim, E. S., additional, Kiseleva, N. V., additional, Klimenko, D. A., additional, Klimova, A. V., additional, Kovalishena, O. V., additional, Kolmakova, E. V., additional, Kolchinskaya, T. P., additional, Kolyadich, M. I., additional, Kondriakova, O. V., additional, Konoval, M. P., additional, Konstantinov, D. Yu., additional, Konstantinova, E. A., additional, Kordukova, V. A., additional, Koroleva, E. V., additional, Kraposhina, A. Yu., additional, Kriukova, T. V., additional, Kuznetsova, A. S., additional, Kuzmina, T. Y., additional, Kuzmichev, K. V., additional, Kulchoroeva, Ch. K., additional, Kuprina, T. V., additional, Kouranova, I. M., additional, Kurenkova, L. V., additional, Kurchugina, N. Yu., additional, Kushubakova, N. A., additional, Levankova, V. I., additional, Levin, M. E., additional, Lyubavina, N. A., additional, Magdeyeva, N. A., additional, Mazalov, K. V., additional, Majseenko, V. I., additional, Makarova, A. S., additional, Maripov, A. M., additional, Marusina, A. A., additional, Melnikov, E. S., additional, Moiseenko, N. B., additional, Muradova, F. N., additional, Muradyan, R. G., additional, Musaelian, Sh. N., additional, Nikitina, N. M., additional, Ogurlieva, B. B., additional, Odegova, A. A., additional, Omarova, Yu. M., additional, Omurzakova, N. A., additional, Ospanova, Sh. O., additional, Pahomova, E. V., additional, Petrov, L. D., additional, Plastinina, S. S., additional, Pogrebetskaya, V. A., additional, Polyakov, D. S., additional, Ponomarenko, E. V., additional, Popova, L. L., additional, Prokofeva, N. A., additional, Pudova, I. A., additional, Rakov, N. A., additional, Rakhimov, A. N., additional, Rozanova, N. A., additional, Serikbolkyzy, S., additional, Simonov, A. A., additional, Skachkova, V. V., additional, Smirnova, L. A., additional, Soloveva, D. V., additional, Soloveva, I. A., additional, Sokhova, F. M., additional, Subbotin, A. K., additional, Sukhomlinova, I. M., additional, Sushilova, A. G., additional, Tagayeva, D. R., additional, Titojkina, Yu. V., additional, Tikhonova, E. P., additional, Tokmin, D. S., additional, Torgunakova, M. S., additional, Trenogina, K. V., additional, Trostianetckaia, N. A., additional, Trofimov, D. A., additional, Tulichev, A. A., additional, Tupitsin, D. I., additional, Tursunova, A. T., additional, Tiurin, A. A., additional, Ulanova, N. D., additional, Fatenkov, O. V., additional, Fedorishina, O. V., additional, Fil, T. S., additional, Fomina, I. Yu., additional, Fominova, I. S., additional, Frolova, I. A., additional, Tsvinger, S. M., additional, Tsoma, V. V., additional, Cholponbaeva, M. B., additional, Chudinovskikh, T. I., additional, Shakhgildyan, L. D., additional, Shevchenko, O. A., additional, Sheshina, T. V., additional, Shishkina, E. A., additional, Shishkov, K. Yu., additional, Sherbakov, S. Y., additional, and Yausheva, E. A., additional
Published: 2021
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37. 16S rRNA gene sequencing data of the upper respiratory tract microbiome in the SARS-CoV-2 infected patients

Author: Julia Galeeva, Vladislav Babenko, Ramiz Bakhtyev, Vladimir Baklaushev, Larisa Balykova, Pavel Bashkirov, Julia Bespyatykh, Anna Blagonravova, Daria Boldyreva, Dmitry Fedorov, Ilshat Gafurov, Raushaniya Gaifullina, Elena Galova, Alina Gospodaryk, Elena Ilina, Konstantin Ivanov, Daria Kharlampieva, Polina Khromova, Ksenia Klimina, Konstantin Kolontarev, Nadezhda Kolyshkina, Andrey Koritsky, Vyacheslav Kuropatkin, Vasily Lazarev, Alexander Manolov, Valentin Manuvera, Daria Matyushkina, Maxim Morozov, Ekaterina Moskaleva, Varvara Musarova, Oleg Ogarkov, Elizaveta Orlova, Alexander Pavlenko, Alla Petrova, Natalia Pozhenko, Dmitry Pushkar, Alexander Rumyantsev, Sergey Rumyantsev, Vladimir Rumyantsev, Lyubov Rychkova, Alexander Samoilov, Irina Shirokova, Vyacheslav Sinkov, Svetlana Solovieva, Elizaveta Starikova, Polina Tikhonova, Galina Trifonova, Alexander Troitsky, Alexander Tulichev, Yuri Udalov, Anna Varizhuk, Alexander Vasiliev, Vladimir Veselovsky, Rinat Vereshchagin, Alexey Volnukhin, Gaukhar Yusubalieva, and Vadim Govorun
Subjects: Q1-390, 16S, Multidisciplinary, Science (General), SARS-CoV-2, Computer applications to medicine. Medical informatics, R858-859.7, Microbiome, Upper respiratory tract, Data Article
Abstract: The SARS-CoV-2 pandemic is a big challenge for humanity. The COVID-19 severity differs significantly from patient to patient, and it is important to study the factors protecting from severe forms of the disease. Respiratory microbiota may influence the patient's susceptibility to infection and disease severity due to its ability to modulate the immune system response of the host organism. This data article describes the microbiome dataset from the upper respiratory tract of SARS-CoV-2 positive patients from Russia. This dataset reports the microbial community profile of 335 human nasopharyngeal swabs collected between 2020-05 and 2021-03 during the first and the second epidemic waves. Samples were collected from both inpatients and outpatients in 4 cities of the Russian Federation (Moscow, Kazan, Irkutsk, Nizhny Novgorod) and sequenced using the 16S rRNA gene amplicon sequencing of V3-V4 region. Data contains information about the patient such as age, sex, hospitalization status, percent of damaged lung tissue, oxygen saturation (SpO2), respiratory rate, need for supplemental oxygen, chest computer tomography severity score, SARS-CoV-2 lineage, and also information about smoking and comorbidities. The amplicon sequencing data were deposited at NCBI SRA as BioProject PRJNA751478.
Published: 2021

38. Agranulocytosis in Felty’s syndrome: a case from clinical practice

Author: E O Efremova and A A Tulichev
Subjects: Nosology, rheumatoid arthritis, medicine.medical_specialty, Cytopenia, Felty’s syndrome, Cirrhosis, business.industry, lcsh:R, lcsh:Medicine, General Medicine, Disease, medicine.disease, agranulocytosis, Felty's syndrome, Clinical Practice, Rheumatoid arthritis, medicine, Differential diagnosis, Intensive care medicine, business
Abstract: Differential diagnosis of articular syndrome is one of the leading issues of primary medical sanitary care. Timely and correct diagnosis of rheumatic diseases made by an internist in an out-patient setting is a cornerstone of successful treatment and prevention of possible complications. The masks of clinical course, subtle symptoms, as well as pathomorphosis of the disease make the accurate diagnosis difficult to establish. Among rheumatic diseases more and more often isolated hematological manifestations are observed on the onset of the disease. Among them the leading place is taken by Felty’s syndrome. Being a form of seropositive rheumatoid arthritis, it is often associated with cytopenia. The aim of the article is to draw attention to the problem of timely diagnosis of Felty’s syndrome. The presented clinical case of Felty’s syndrome with agranulocytosis was based on clinical, laboratory, instrumental data obtained on examination of a patient. The features of the course, diagnostic methods and treatment methods of the pathology are discussed. The treatment efficacy of corticosteroids and cytostatics, similarities in clinical presentation and course of the syndrome with lymphoproliferative diseases and liver cirrhosis are presented. According to the obtained data a conclusion was made about the need for early diagnosis and complex examination in case of Felty’s syndrome for successful treatment of the nosology.
Published: 2018

39. International register “Dynamics analysis of comorbidities in SARS-CoV-2 survivors” (AKTIV SARS-CoV-2): analysis of 1,000 patients

Author: Arutyunov, G. P., primary, Tarlovskaya, E. I., additional, Arutyunov, A. G., additional, Belenkov, Y. N., additional, Konradi, A. O., additional, Lopatin, Y. M., additional, Tereshchenko, S. N., additional, Rebrov, A. P., additional, Chesnikova, A. I., additional, Fomin, I. V., additional, Grigorieva, N. V., additional, Boldina, M. V., additional, Vaisberg, A. R., additional, Blagonravova, A. S., additional, Makarova, E. V., additional, Shaposhnik, I. I., additional, Kuznetsova, T. Yu., additional, Malchikova, S. V., additional, Protsenko, D. N., additional, Evzerikhina, A. V., additional, Petrova, M. M., additional, Demko, I. V., additional, Saphonov, D. V., additional, Hayrapetyan, H. G., additional, Galyavich, A. S., additional, Kim, Z. F., additional, Sugraliev, A. B., additional, Nedogoda, S. V., additional, Tsoma, V. V., additional, Sayganov, S. A., additional, Gomonova, V. V., additional, Gubareva, I. V., additional, Sarybaev, A. Sh., additional, Koroleva, E. V., additional, Vilkova, O. E., additional, Fomina, I. Y., additional, Pudova, I. A., additional, Soloveva, D. V., additional, Kiseleva, N. V., additional, Zelyaeva, N. V., additional, Kouranova, I. M., additional, Pogrebetskaya, V. A., additional, Muradova, F. N., additional, Badina, O. Y., additional, Kovalishena, O. V., additional, Galova, E. A., additional, Plastinina, S. S., additional, Lyubavina, N. A., additional, Vezikova, N. N., additional, Levankova, V. I., additional, Ivanova, S. Yu., additional, Ermilova, A. N., additional, Muradyan, R. G., additional, Gostishev, R. V., additional, Tikhonova, E. P., additional, Kuzmina, T. Y., additional, Soloveva, I. A., additional, Kraposhina, A. Yu., additional, Kolyadich, M. I., additional, Kolchinskaya, T. P., additional, Genkel, V. V., additional, Kuznetsova, A. S., additional, Kazakovtseva, M. V., additional, Odegova, A. A., additional, Chudinovskikh, T. I., additional, Baramzina, S. V., additional, Rozanova, N. A., additional, Kerimova, A. Sh., additional, Krivosheina, N. A., additional, Chukhlova, S. Y., additional, Levchenko, A. A., additional, Avoyan, H. G., additional, Azarian, K. K., additional, Musaelian, Sh. N., additional, Avetisian, S. A., additional, Levin, M. E., additional, Karpov, O. V., additional, Sokhova, F. M., additional, Burygina, L. A., additional, Sheshina, T. V., additional, Tiurin, A. A., additional, Dolgikh, O. Yu., additional, Kazymova, E. V., additional, Konstantinov, D. Yu., additional, Chumakova, O. A., additional, Kondriakova, O. V., additional, Shishkov, K. Yu., additional, Fil, T. S., additional, Prokofeva, N. A., additional, Konoval, M. P., additional, Simonov, A. A., additional, Bitieva, A. M., additional, Trostianetckaia, N. A., additional, Cholponbaeva, M. B., additional, Kerimbekova, Zh. B., additional, Duyshobayev, M. Y., additional, Akunov, A. Ch., additional, Kushubakova, N. A., additional, Melnikov, E. S., additional, Kim, E. S., additional, Sherbakov, S. Y., additional, Trofimov, D. A., additional, Evdokimov, D. S., additional, Ayipova, D. A., additional, Duvanov, I. A., additional, Abdrahmanova, A. K., additional, Aimakhanova, G. T., additional, Ospanova, Sh. O., additional, Dabylova, G. M., additional, Tursunova, A. T., additional, Xaskaeva, D. S., additional, Tulichev, A. A., additional, Ashina, E. Yu., additional, Kordukova, V. A., additional, Barisheva, O. Yu., additional, Egorova, K. E., additional, Varlamova, D. D., additional, Kuprina, T. V., additional, Pahomova, E. V., additional, Kurchugina, N. Yu., additional, Frolova, I. A., additional, Mazalov, K. V., additional, Subbotin, A. K., additional, Kamardina, N. A., additional, Zarechnova, N. V., additional, Mamutova, E. M., additional, Smirnova, L. A., additional, Klimova, A. V., additional, Shakhgildyan, L. D., additional, Tokmin, D. S., additional, Tupitsin, D. I., additional, Kriukova, T. V., additional, Rakov, N. A., additional, and Polyakov, D. S., additional
Published: 2020
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40. International register “Analysis of Chronic Non-infectious Diseases Dynamics After COVID-19 Infection in Adult Patients (ACTIV SARS-CoV-2)”

Author: Arutyunov, G. P., primary, Tarlovskaya, E. I., additional, Arutyunov, A. G., additional, Belenkov, Y. N., additional, Konradi, A. O., additional, Lopatin, Y. M., additional, Tereshchenko, S. N., additional, Rebrov, A. P., additional, Chesnikova, A. I., additional, Fomin, I. V., additional, Grigorieva, N. U., additional, Boldina, V. M., additional, Vaisberg, A. R., additional, Blagonravova, A. S., additional, Makarova, E. V., additional, Shaposhnik, I. I., additional, Kuznetsova, T. Y., additional, Malchikova, S. V., additional, Protsenko, D. N., additional, Evzerikhina, A. V., additional, Petrova, M. M., additional, Demko, I. V., additional, Saphonov, D. V., additional, Hayrapetyan, H. G., additional, Galyavich, A. S., additional, Kim, Z. F., additional, Sugraliev, A. B., additional, Nedogoda, S. V., additional, Tsoma, V. V., additional, Sayganov, S. A., additional, Gomonova, V. V., additional, Gubareva, I. V., additional, Sarybaev, A. S., additional, Ruzanau, D. Y., additional, Majseenko, V. I., additional, Babin, A. P., additional, Kamilova, U. K., additional, Koroleva, E. V., additional, Vilkova, O. E., additional, Fomina, I. Y., additional, Pudova, I. A., additional, Soloveva, D. V., additional, Doshchannikov, D. A., additional, Kiseleva, N. V., additional, Zelyaeva, N. V., additional, Kouranova, I. M., additional, Pogrebetskaya, V. A., additional, Muradova, F. N., additional, Omarova, Y. V., additional, Badina, O. Y., additional, Kovalishena, O. V., additional, Gаlova, A. E., additional, Plastinina, S. S., additional, Grigorovich, M. S., additional, Lyubavina, N. A., additional, Vezikova, N. N., additional, Levankova, V. I., additional, Ivanova, S. Y., additional, Ermilova, A. N., additional, Muradyan, R. G., additional, Gostishev, R. V., additional, Tikhonova, E. P., additional, Kuzmina, T. Y., additional, Soloveva, I. A., additional, Kraposhina, A. Y., additional, Kolyadich, M. I., additional, Kolchinskaya, T. P., additional, Genkel, V. V., additional, Kuznetsova, A. S., additional, Kazakovtseva, M. V., additional, Odegova, A. A., additional, Chudinovskikh, T. I., additional, Baramzina, S. V., additional, Rozanova, N. A., additional, Kerimova, A. S., additional, Krivosheina, N. A., additional, Chukhlova, S. Y., additional, Levchenko, A. A., additional, Avoyan, H. G., additional, Azarian, K. K., additional, Musaelian, S. N., additional, Avetisian, S. A., additional, Levin, M. E., additional, Karpov, O. V., additional, Sokhova, F. M., additional, Burygina, L. A., additional, Sheshina, T. V., additional, Tiurin, A. A., additional, Dolgikh, O. Y., additional, Kazymova, E. V., additional, Konstantinov, D. Y., additional, Chumakova, O. A., additional, Kondriakova, O. V., additional, Shishkov, K. Y., additional, Fil, S. T., additional, Prokofeva, N. A., additional, Konoval, M. P., additional, Simonov, A. A., additional, Bitieva, A. M., additional, Trostianetckaia, N. A., additional, Cholponbaeva, M. B., additional, Kerimbekova, Z. B., additional, Duyshobayev, M. Y., additional, Akunov, A. C., additional, Kushubakova, N. A., additional, Melnikov, E. S., additional, Kim, E. S., additional, Sherbakov, S. Y., additional, Trofimov, D. A., additional, Evdokimov, D. S., additional, Ayipova, D. A., additional, Duvanov, I. A., additional, Abdrahmanova, A. K., additional, Aimakhanova, G. T., additional, Ospanova, S. O., additional, Dabylova, G. M., additional, Tursunova, A. T., additional, Kaskaeva, D. S., additional, Tulichev, A. A., additional, Ashina, E. Y., additional, Kordukova, V. A., additional, Barisheva, O. Y., additional, Egorova, K. E., additional, Varlamova, D. D., additional, Kuprina, T. V., additional, Pahomova, E. V., additional, Kurchugina, N. Y., additional, Frolova, I. A., additional, Mazalov, K. V., additional, Subbotin, A. K., additional, Kamardina, N. A., additional, Zarechnova, N. V., additional, Mamutova, E. M., additional, Smirnova, L. A., additional, Klimova, A. V., additional, Shakhgildyan, L. D., additional, Tokmin, D. S., additional, Tupitsin, D. I., additional, Kriukova, T. V., additional, Polyakov, D. S., additional, Karoli, N. A., additional, Grigorieva, E. V., additional, Magdeyeva, N. A., additional, Aparkina, A. V., additional, Nikitina, N. M., additional, Petrov, L. D., additional, Budu, A. M., additional, Rasulova, Z. D., additional, Tagayeva, D. R., additional, Fatenkov, O. V., additional, Gubareva, E. Y., additional, Demchenko, A. I., additional, Klimenko, D. A., additional, Serikbolkyzy, S., additional, and Zheldybayeva, A. E., additional
Published: 2020
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41. Differential diagnostic of stenosing ligamentitis and rheumatoid arthritis

Author: Borovkova, N. Yu., primary, Sumin, P. M., additional, Tulichev, A. A., additional, Starshov, A. S., additional, Plastinina, S. S., additional, and Berezina, N. A., additional
Published: 2020
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42. Immunological Approaches to the Treatment of Novel Coronavirus Infection (Review)

Author: S. S. Plastinina, Nikolay Menkov, A.A. Tulichev, M.Yu. Milyutina, L. V. Tyurikova, Natalya Lyubavina, Ekaterina Makarova, M.L. Shonia, and S.G. Saltsev
Subjects: Reviews, medicine.disease_cause, prophylactic vaccines, immune response, General Biochemistry, Genetics and Molecular Biology, Virus, coronavirus infection, Immune system, Pandemic, Humans, pneumonia, Medicine, Pandemics, lung damage, Coronavirus, biology, SARS-CoV-2, business.industry, Mesenchymal stem cell, COVID-19, General Medicine, medicine.disease, COVID-19 Drug Treatment, Host-Pathogen Interactions, cytokine storm, Immunology, biology.protein, Antibody, business, Cytokine storm, Pneumonia (non-human)
Abstract: The pandemic of the new coronavirus infection (COVID-19) caused by the SARS-CoV-2 virus has spread all over the world. The large amount of information that appears every day requires comprehension and systematization. The immunological aspects of the virus-host interaction are the core issues in the effective treatment and prevention of COVID-19’ development. The review analyzes the known pathways of the viral invasion and evasion, the mechanisms of the cytokine storm, endothelial damage, and hypercoagulability associated with SARS-CoV-2 infection. Clinical data from previous SARS and MERS epidemics is discussed here. We also address the therapeutic approaches based on the basic knowledge of immune response and the blood cells’ immune functions, as well as the ways to reduce their hyperactivation. The use of interferon therapy, anti-inflammatory therapy, anti-cytokine therapy, neutralizing antibodies, convalescent plasma, and mesenchymal stem cells, as well as prophylactic vaccines, is discussed.
Published: 2021

43. Daily indices of central and peripheral blood pressure in patients with chronic glomerulonephritis and arterial hypertension at different stages of chronic kidney disease

Author: Polyakova, I V, primary, Borovkova, N Yu, additional, Tulichev, A A, additional, Maslova, T I, additional, Linyova, N Yu, additional, Zubova, S Yu, additional, and Maksimova, I Yu, additional
Published: 2019
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44. SELECTION OF THE OPTIMAL ANTIHYPERTENSION TREATMENT IN PATIENTS WITH CHRONIC HEART FAILURE WITH THE SIGNS OF CHRONIC KIDNEY DISEASE

Author: Borovkova, N. Yu, primary, Kuznetsova, Т. Е., additional, Borovkov, N. N., additional, Tulichev, A. A., additional, and Ilyina, A. S., additional
Published: 2016
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45. ACTIV SARS-CoV-2 registry (Analysis of Chronic Non-infectious Diseases Dynamics After COVID-19 Infection in Adult Patients). Assessment of impact of combined original comorbid diseases in patients with COVID-19 on the prognosis

Author: Gregory P. Arutyunov, Ekaterina I. Tarlovskaya, Alexander G. Arutyunov, Yuri N. Belenkov, Alexandra O. Konradi, Yury M. Lopatin, Andrey P. Rebrov, Sergey N. Tereshchenko, Anna I. Chesnikova, Hamlet G. Hayrapetyan, Aleksandr P. Babin, Igor G. Bakulin, Natalia V. Bakulina, Larisa A. Balykova, Anna S. Blagonravova, Marina V. Boldina, Alexandra R. Vaisberg, Albert S. Galyavich, Veronika V. Gomonova, Natalia Yu. Grigorieva, Irina V. Gubareva, Irina V. Demko, Angelika V. Evzerikhina, Aleksandr V. Zharkov, Umida K. Kamilova, Zulfia F. Kim, Tatiana Yu. Kuznetsova, Natalia V. Lareva, Ekaterina V. Makarova, Svetlana V. Malchikova, Sergey V. Nedogoda, Marina M. Petrova, Ilya G. Pochinka, Konstantin V. Protasov, Denis N. Protsenko, Dmitry Yu. Ruzanau, Sergey A. Sayganov, Akpay S. Sarybaev, Natalia M. Selezneva, Akhmetzhan B. Sugraliev, Igor V. Fomin, Olga V. Khlynova, Olga Yu. Chizhova, Igor I. Shaposhnik, Dmitry A. Sh'ukarev, Айгуль K. Abdrahmanova, Susanna A. Avetisian, Hovhannes G. Avoyan, Karine K. Azarian, Galiya T. Aimakhanova, Dinara A. Ayipova, Almazbek Ch. Akunov, Marianna K. Alieva, Aliona V. Aparkina, Olga R. Aruslanova, Ekaterina Yu. Ashina, Olga Yu. Badina, Olga Yu. Barisheva, Alina S. Batchayeva, Anna M. Bitieva, Ismail U. Bikhteyev, Nataliya A. Borodulina, Maksim V. Bragin, Angela M. Budu, Galina M. Bykova, Kristina R. Vagapova, Darina D. Varlamova, Natalia N. Vezikova, Elena A. Verbitskaya, Olga E. Vilkova, Elena A. Vinnikova, Vera V. Vustina, Elena A. Galova, Vadim V. Genkel, Elena I. Gorshenina, Roman V. Gostishev, Elena V. Grigorieva, Ekaterina Yu. Gubareva, Gaukhar M. Dabylova, Anastasiya I. Demchenko, Oleg Yu. Dolgikh, Melis Y. Duyshobayev, Dmitrii S. Evdokimov, Ksenia E. Egorova, Anastasiia N. Ermilova, Aliya E. Zheldybayeva, Nataliya V. Zarechnova, Yuliia D. Zimina, Svetlana Yu. Ivanova, Elena Yu. Ivanchenko, Mariya V. Ilina, Maria V. Kazakovtseva, Elena V. Kazymova, Yuliya S. Kalinina, Nadezhda A. Kamardina, Anastasiya M. Karachenova, Igor A. Karetnikov, Nina A. Karoli, Magomed Kh. Karsiev, Daria S. Кaskaeva, Karina F. Kasymova, Zhainagul B. Kerimbekova, Ailar Sh. Kerimova, Eugeni S. Kim, Nina V. Kiseleva, Darya A. Klimenko, Anastasiia V. Klimova, Olga V. Kovalishena, Elena V. Kolmakova, Tatyana P. Kolchinskaya, Maria I. Kolyadich, Olga V. Kondriakova, Marina P. Konoval, Dmitryi Yu. Konstantinov, Elena A. Konstantinova, Vera A. Kordukova, Ekaterina V. Koroleva, Angelina Yu. Kraposhina, Tamara V. Kriukova, Alla S. Kuznetsova, Tatyana Yu. Kuzmina, Kirill V. Kuzmichev, Cholpon K. Kulchoroevna, Tatiana V. Kuprina, Irina M. Kouranova, Liliya V. Kurenkova, Natalia Yu. Kurchugina, Nadira A. Kushubakova, Valeriia I. Levankova, Natalia A. Lyubavina, Nadezhda A. Magdeyeva, Konstantin V. Mazalov, Viktoryia I. Majseenko, Aleksandra S. Makarova, Abdirashit M. Maripov, Anastasiia A. Marusina, Evgenii S. Melnikov, Nikita B. Moiseenko, Fazliniso N. Muradova, Rimma G. Muradyan, Shahane N. Musaelian, Anton O. Myshak, Ekaterina S. Nekaeva, Nataliia M. Nikitina, Bela B. Ogurlieva, Alla A. Odegova, Yuliia V. Omarova, Nazgul A. Omurzakova, Shynar O. Ospanova, Ekaterina V. Pahomova, Liviu D. Petrov, Svetlana S. Plastinina, Vera A. Pogrebetskaya, Dmitry S. Polyakov, Ekaterina V. Ponomarenko, Larisa L. Popova, Natalya A. Prokofeva, Inna A. Pudova, Nikita A. Rakov, Abdurakhmon N. Rahimov, Nadezhda A. Rozanova, Saltanat Serikbolkyzy, Andrei A Simonov, Valeriya V. Skachkova, Daria V. Soloveva, Irina A. Soloveva, Alexander K. Subbotin, Irina M. Sukhomlinova, Anastasiia G. Sushilova, Dilnoza R. Tagayeva, Yuliia V. Titojkina, Elena P. Tikhonova, Danil S. Tokmin, Anastasiia A. Tolmacheva, Mariya S. Torgunakova, Ksenia V. Trenogina, Natalia A. Trostianetckaia, Dmitriy A. Trofimov, Alexander A. Tulichev, Assiya T. Tursunova, Nina D. Ulanova, Oleg V. Fatenkov, Olga V. Fedorishina, Tatiana S. Fil, Irina Yu. Fomina, Irina S. Fominova, Irina A. Frolova, Svetlana M. Tsvinger, Vera V. Tsoma, Meerim B. Cholponbaeva, Tatiana I. Chudinovskikh, Olga A. Shevchenko, Tatyana V. Sheshina, Ekaterina A. Shishkina, Konstantin Yu. Shishkov, Stanislav Yu. Sherbakov, and Ekaterina A. Yausheva
Subjects: covid-19, activ registry, cardiovascular diseases, diabetes mellitus, polymorbidity, disease combinations, Medicine
Abstract: Aim. Study the impact of various combinations of comorbid original diseases in patients infected with COVID-19 later on the disease progression and outcomes of the new coronavirus infection. Materials and methods. The ACTIV registry was created on the Eurasian Association of Therapists initiative. 5,808 patients have been included in the registry: men and women with COVID-19 treated at hospital or at home. ClinicalTrials.gov ID NCT04492384. Results. Most patients with COVID-19 have original comorbid diseases (oCDs). Polymorbidity assessed by way of simple counting of oCDs is an independent factor in negative outcomes of COVID-19. Search for most frequent combinations of 2, 3 and 4 oCDs has revealed absolute domination of cardiovascular diseases (all possible variants). The most unfavorable combination of 2 oCDs includes atrial hypertension (AH) and chronic heart failure (CHF). The most unfavorable combination of 3 oCDs includes AH, coronary heart disease (CHD) and CHF; the worst combination of 4 oCDs includes AH, CHD, CHF and diabetes mellitus. Such combinations increased the risk of lethal outcomes 3.963, 4.082 and 4.215 times respectively. Conclusion. Polymorbidity determined by way of simple counting of diseases may be estimated as a factor in the lethal outcome risk in the acute phase of COVID-19 in real practice. Most frequent combinations of 2, 3 and 4 diseases in patients with COVID-19 primarily include cardiovascular diseases (AH, CHD and CHF), diabetes mellitus and obesity. Combinations of such diseases increase the COVID-19 lethal outcome risk.
Published: 2022
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