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383 results on '"A. Bosseray"'

2. Screening of hepatitis E in patients presenting for acute neurological disorders

Author

Aude Belbézier, Alban Deroux, Françoise Sarrot-Reynauld, Barbara Colombe, Annick Bosseray, Claire Wintenberger, Perrine Dumanoir, Maxime Lugosi, Isabelle Boccon-Gibod, Vincent Leroy, Maxime Maignan, Roselyne Collomb-Muret, Damien Viglino, Mathieu Vaillant, Lorella Minotti, Emeline Lagrange, Olivier Epaulard, Chantal Dumestre-Perard, Sébastien Lhomme, Julien Lupo, Sylvie Larrat, Patrice Morand, Carole Schwebel, Antoine Vilotitch, Jean-Luc Bosson, and Laurence Bouillet

Subjects
Hepatitis E, Neurological disorder, Acute hepatitis, Hepatitis, Infectious and parasitic diseases, RC109-216, Public aspects of medicine, RA1-1270
Abstract

Introduction: Hepatitis E virus (HEV) infection has been reported to be associated with neurological disorders. However, the real prevalence of acute hepatitis E in those diseases is still unknown. We determined the prevalence of anti-HEV IgM antibody in a population with acute non-traumatic, non-metabolic, non-vascular neurological injury. Method: A registry was created in Grenoble Hospital University from 2014 to 2018 to collect data on patients with acute (

Published
2020
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3. Un pancréas vexé

Author

Dionnet, N., primary, Garcin, F., additional, Potié, O., additional, Djeddar, A., additional, Vangout, M., additional, Bosseray, A., additional, Bocquet, A., additional, and Bouillet, L., additional

Published
2023
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6. Prolonged suppressive antibiotic therapy for prosthetic joint infection in the elderly: a national multicentre cohort study

Author

Prendki, V., Ferry, T., Sergent, P., Oziol, E., Forestier, E., Fraisse, T., Tounes, S., Ansart, S., Gaillat, J., Bayle, S., Ruyer, O., Borlot, F., Le Falher, G., Simorre, B., Dauchy, F.-A., Greffe, S., Bauer, T., Bell, E. N., Martha, B., Martinot, M., Froidure, M., Buisson, M., Waldner, A., Lemaire, X., Bosseray, A., Maillet, M., Charvet, V., Barrelet, A., Wyplosz, B., Noaillon, M., Denes, E., Beretti, E., Berlioz-Thibal, M., Meyssonnier, V., Fourniols, E., Tliba, L., Eden, A., Jean, M., Arvieux, C., Guignery-Kadri, K., Ronde-Oustau, C., Hansmann, Y., Belkacem, A., Bouchand, F., Gavazzi, G., Herrmann, F., Stirnemann, J., and Dinh, A.

Published
2017
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7. Profils des myosites auto-immunes avec ou sans atteinte pulmonaire : une étude monocentrique rétrospective de 40 patients

Author

O. Chol, A. Deroux, A. Bosseray, C. Dumestre-Perard, S. Quetant, A. Bocquet, L. Bouillet, Centre Hospitalier Universitaire [Grenoble] (CHU), Institut de biologie structurale (IBS - UMR 5075), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)

Subjects
[SDV]Life Sciences [q-bio], Gastroenterology, Internal Medicine
Published
2023
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8. The onset of late severe lung impairment in COVID-19 is associated with high inflammation markers at admission and metabolic syndrome markers

Author

Olivier Epaulard, Audrey Le Gouellec, Marion Le Marechal, Benjamin Nemoz, Anne-Laure Borel, Anaïs Dartevel, Hubert Gheerbrant, Marie-Christine Herault, Annick Bosseray, Giovanna Clavarino, Julien Lupo, Damien Viglino, Fanny Quenard, Clara Candille, Boubou Camara, Michel Durand, Patrice Faure, Dorra Guergour, Elena Chidlovski, Marie-Christine Jacob, Sylvie Larrat, Marie Froidure, Nicolas Terzi, Sébastien Quetant, Jean-François Payen, Barbara Colombe, Tatiana Raskovalova, Patrice Morand, Isabelle Pierre, Carole Schwebel, Rebecca Hamidfar, Laurence Bouillet, Jean-Paul Brion, Candice Trocme, Sylvie Berthier, Carole Chirica, Anne-Laure Mounayar, Myriam Blanc, Patricia Pavese, and Bertrand Toussaint

Abstract

BackgroundCOVID-19 severity is mainly related to lung impairment. However, preexisting patient characteristics and biomarkers at admission associated with this event are not precisely known.MethodsWe report 205 patients admitted for a proven COVID-19 in our institution between March 7 and April 22, 2020, particularly their comorbidities, respiratory severity, immune profile, and metabolic profile.FindingsMedian age was 70 years [interquartile range (IQR) 25-75: 60;79]; 115 (56·1%) patients were men. Oxygen supplementation of >2L/min was required in 107 patients (52·2%) after a median time of 8 days [IQR: 6;10] after the first symptoms; 67 (32·7%) patients were admitted to the intensive care unit (ICU), almost exclusively due to severe hypoxia. Patients requiring >2L/min oxygen therapy and/or ICU admission were older and more frequently males, with a significantly higher body mass index (BMI), a significantly higher total cholesterol (TC) / HDL cholesterol ratio, and higher triglycerides. They also had higher plasma levels of C-reactive protein (CRP) and interleukin 6 (IL-6); IL-6 >20 ng/L and CRP >70 mg/L were significantly associated with ICU admission and/or (for patients with a decision of limitation of life-support therapy) death. Higher BMI and TC/HDL-c ratio were associated with higher CRP and IL-6 levels. Steroid therapy was performed in 61 patients; while its clinical impact was inconclusive due to heterogeneous situations, IL-6 levels decreased significantly more in these patients.InterpretationSevere COVID-19 mostly relates to late-onset pneumonia associated with preexisting metabolic syndrome markers and a surge in inflammatory markers, allowing the early identification of at-risk patients.FundingThis work was supported by Foundation University of Grenoble Alpes.

Published
2022
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9. The onset of late severe lung impairment in COVID-19 is associated with high inflammation markers at admission and metabolic syndrome markers

Author

Epaulard, Olivier, primary, Le Gouellec, Audrey, additional, Le Marechal, Marion, additional, Nemoz, Benjamin, additional, Borel, Anne-Laure, additional, Dartevel, Anaïs, additional, Gheerbrant, Hubert, additional, Herault, Marie-Christine, additional, Bosseray, Annick, additional, Clavarino, Giovanna, additional, Lupo, Julien, additional, Viglino, Damien, additional, Quenard, Fanny, additional, Candille, Clara, additional, Camara, Boubou, additional, Durand, Michel, additional, Faure, Patrice, additional, Guergour, Dorra, additional, Chidlovski, Elena, additional, Jacob, Marie-Christine, additional, Larrat, Sylvie, additional, Froidure, Marie, additional, Terzi, Nicolas, additional, Quetant, Sébastien, additional, Payen, Jean-François, additional, Colombe, Barbara, additional, Raskovalova, Tatiana, additional, Morand, Patrice, additional, Pierre, Isabelle, additional, Schwebel, Carole, additional, Hamidfar, Rebecca, additional, Bouillet, Laurence, additional, Brion, Jean-Paul, additional, Trocme, Candice, additional, Berthier, Sylvie, additional, Chirica, Carole, additional, Mounayar, Anne-Laure, additional, Blanc, Myriam, additional, Pavese, Patricia, additional, and Toussaint, Bertrand, additional

Published
2022
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12. Borrelia crocidurae Meningoencephalitis, West Africa

Author

Sandrine Goutier, Elisabeth Ferquel, Claudine Pinel, Annick Bosseray, Bruno Hoen, Gérard Couetdic, Amina Bourahoui, Claire Lapostolle, Hervé Pelloux, Martine Garnier, Natacha Sertour, Isabelle Pelloux, Patricia Pavese, and Muriel Cornet

Subjects
Borrelia crocidurae, meningitis, encephalitis, molecular diagnosis, West Africa, Borrelia meningitis, Medicine, Infectious and parasitic diseases, RC109-216
Abstract

Borrelia crocidurae–associated relapsing fever is endemic to West Africa and is considered benign. We report 4 patients with B. crocidurae–associated neurologic symptoms; 2 of their cases had been misdiagnosed. Frequency and severity of this disease could be underestimated; molecular methods and serodiagnostic tests for Lyme disease might be helpful in its detection.

Published
2013
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13. The consequences of COVID-19 pandemic on patients with monoclonal gammopathy–associated systemic capillary leak syndrome (Clarkson disease)

Author

Pineton de Chambrun, Marc, Gousseff, Marie, Mauhin, Wladimir, Hot, Arnaud, Lega, Jean-Christophe, Lambert, Marc, Riviere, Sophie, Dossier, Antoine, Ruivard, Marc, Lhote, François, Blaison, Gilles, Merceron, Sybille, Zapella, Nathalie, Alric, Laurent, Agard, Christian, Lacout, Mathieu, Saadoun, David, Graveleau, Julie, Soubrier, Martin, Haroche, Julien, Boileau, Julien, Lucchini-Lecomte, Marie-Josee, Hanslik, Thomas, Christides, Christine, Levesque, Hervé, Talasczka, Aline, Bulte, Caroline, Hachulla, Eric, Decaux, Olivier, Sonneville, Romain, Ibouanga, Florent, Arnulf, Bertrand, Benedit, Marcel, Viallard, Jean François, Tieulie, Nathalie, Haddad, Fadi, Moulin, Bruno, Cohen-Aubert, Fleur, Lovey, Pierre-Yves, le Moal, Sylvie, Bibes, Béatrice, Rivard, Georges-Etienne, Rondeau, Eric, Malizia, Giuseppe, Debourdeau, Philippe, Abgueguen, Pierre, Bosseray, Annick, Devaquet, Jérôme, Presne, Claire, Liferman, François, Limal, Nicolas, Argaud, Laurent, Hernu, Romain, de la Salle, Sylvie, Faguer, Stanislas, Urbanski, Geoffrey, Zucman, Noémie, Werner, Marie, Luyt, Charles-Edouard, Moyon, Quentin, Verlicchi, Franco, Troncoso, Jorge Álvarez, Harty, John, Godmer, Pascal, Hie, Miguel, Papo, Thomas, Hatron, Pierre-Yves, Mathian, Alexis, and Amoura, Zahir

Published
2022
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14. Verbesserung der Logistikeffizienz: Benchmark-Studie Krankenhauslogistik 2020

Author

Hubert Otten and Sebastian Bosseray

Abstract

Zum dritten Mal wurde im Institut für Health Care Management eine Benchmark-Studie Krankenhauslogistik durchgeführt. In diesem Kontext wurden jeweils Struktur- und Transportmassendaten erhoben und Kennzahlenwerte zu Produktivität, Servicequalität, Auftragsstabilität und Kosten berechnet. Ausgewählte Auszüge aus der Studie werden im folgenden Fachbeitrag vorgestellt.

Published
2021
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15. [Profiles of autoimmune myositis with or without pulmonary involvement: A retrospective single-center study of 40 patients]

Author

O, Chol, A, Deroux, A, Bosseray, C, Dumestre-Perard, S, Quetant, A, Bocquet, and L, Bouillet

Abstract

Idiopathic inflammatory myopathies (IMM) are rare diseases with clinico-biological heterogeneity. Pulmonary involvement is frequent and associated with some distinctive manifestations. The aim of this study was to describe the clinico-biological profile of patients with autoimmune myositis with and without pulmonary involvement.This retrospective descriptive study included patients with idiopathic inflammatory myopathies and a positive antibody test performed at Grenoble Alpes University Hospital between 2010 and 2020.Forty patients were included, the majority were women. The anti-Jo1 autoantibody was the most frequently found (37.5%). The prevalence of pulmonary involvement was 70%. Mechanics' hands and Raynaud's syndrome were the extra-respiratory signs significantly more present in the group with lung involvement (P0.05), in contrast to creatine kinase levels which were lower in this group (P0.05). Glucocorticoids and rituximab were significantly more often used in the group with lung involvement (P0.05). The 5-year survival rate was 76.2% in patients with lung involvement and 100% in patients without lung involvement (P=0.50).We report a high prevalence of lung involvement probably explained by the presence of many patients with anti-synthetase syndrome. Our study highlights a lower severity of muscle involvement in myositis patients with lung disease, which deserves to be confirmed in a larger study.

Published
2022

16. Intravenous Immunoglobulins Improve Survival in Monoclonal Gammopathy-Associated Systemic Capillary-Leak Syndrome

Author

Pineton de Chambrun, Marc, Gousseff, Marie, Mauhin, Wladimir, Hot, Arnaud, Argaud, Laurent, Hernu, Romain, de la Salle, Sylvie, Lega, Jean-Christophe, Ledochowski, Stanislas, Lambert, Marc, Moreau, Anne-Sophie, Rivière, Sophie, Dossier, Antoine, Papo, Thomas, Sonneville, Romain, Ruivard, Marc, Lhote, François, Verdière, Bruno, Blaison, Gilles, Merceron, Sybille, Zappella, Nathalie, Alric, Laurent, Agard, Christian, Landais, Mickael, Limal, Nicolas, Contou, Damien, Saadoun, David, Similowski, Thomas, Demoule, Alexandre, Graveleau, Julie, Soubrier, Martin, Souweine, Bertrand, Haroche, Julien, Boileau, Julien, Lucchini-Lecomte, Marie-Josée, Lecomte, Bernard, Hanslik, Thomas, Vieillard-Baron, Antoine, Christides, Christine, Bosseray, Annick, Terzi, Nicolas, Levesque, Hervé, Bulte, Caroline, Talasczka, Aline, Hachulla, Eric, Decaux, Olivier, Ibouanga, Florent, Arnulf, Bertrand, Groh, Matthieu, Azoulay, Elie, Benedit, Marcel, Viallard, Jean-François, Tieulie, Nathalie, Maalouf, Assaad, Moulin, Bruno, Cohen-Aubart, Fleur, Lovey, Pierre-Yves, Friolet, Raymond, le Moal, Sylvie, Bibes, Béatrice, Pha, Micheline, Rivard, Georges-Etienne, Rondeau, Eric, Malizia, Giuseppe, Debourdeau, Philippe, Puidupin, Marc, Abgueguen, Pierre, Beloncle, François, Devaquet, Jérôme, Presne, Claire, Liferman, François, Mazou, Jean-Marc, Andrieu, Maude, Paulus, Sylvie, Fedun, Yannick, Mira, Jean-Paul, Raphalen, Jean-Herlé, Len Abad, Oscar, Devilliers, Hervé, Rogers, Alister, Godmer, Pascal, Luyt, Charles-Edouard, Combes, Alain, Hie, Miguel, Mathian, Alexis, Hatron, Pierre-Yves, Ninet, Jacques, Amoura, Zahir, Le Moal, Sylvie, and Lifermann, François

Published
2017
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17. Levels and determinants of breast and cervical cancer screening uptake in HIV‐infected women compared with the general population in France

Author

Tron, L, Lert, F, Spire, B, DraySpira, R, Allègre, T, Mours, P., Riou, J.M., Sordage, M., Chennebault, J. M., Fialaire, P., Rabier, V., Froidure, M., Huguet, D., Leduc, D., Pichancourt, G., Wajsbrot, A., Bourdeaux, C., Foltzer, A., Hoen, B., HustacheMathieu, L., Abgrall, S., Barruet, R., Bouchaud, O., Chabrol, A., Mattioni, S, Mechai, F., Jeantils, V., Bernard, N., Bonnet, F., Hessamfar, M., Lacoste, D., Malvy, D., Mercié, P., Morlat, P., Paccalin, F., Pertusa, M. C., Pistone, T., Receveur, M. C., Vandenhende, M. A., Dupont, C., Freire Maresca, A., Leporrier, J., Rouveix, E., Dargere, S., de la Blanchardière, ., Martin, A., Noyon, V., Verdon, R., Rogeaux, O., Beytout, J., Gourdon, F., Laurichesse, H., Meier, F., Mortier, E., Simonpoli, A. M., Cordier, F., Delacroix, I., Garrait, V., Elharrar, B., Dominguez, S., Lascaux, A. S., Lelièvre, J. D., Levy, Y., Melica, G., Buisson, M., Piroth, L., Waldner, A., Gruat, N., Leprêtre, A., de Truchis, P., Le Du, D, Melchior, J. Cl., Sehouane, R., Troisvallets, D., Blanc, M., BocconGibod, I., Bosseray, A., Brion, J. P., Durand, F., Leclercq, P., Marion, F., Pavese, P., BrottierMancini, E., Faba, L., RoncatoSaberan, M., BollengierStragier, O., Esnault, J. L., LeautezNainville, S., Perré, P., Froguel, E., Nguessan, M., Simon, P., Colardelle, P., Doll, J., GodinCollet, C., RoussinBretagne, S., Delfraissy, J. F., Duracinsky, M., Goujard, C., Peretti, D., Quertainmont, Y., Marionneau, J., Aissi, E., Van Grunderbeeck, N, Denes, E., DucroixRoubertou, S., Genet, C., Weinbreck, P., AugustinNormand, C., Boibieux, A., Cotte, L., Ferry, T., Koffi, J., Miailhes, P., Perpoint, T., Peyramond, D., Schlienger, I., Brunel, J. M., Carbonnel, E., Chiarello, P., Livrozet, J. M., Makhloufi, D., Dhiver, C., Husson, H., Madrid, A., Ravaux, I., de Severac, M.L., Thierry Mieg, M., Tomei, C., Hakoun, S., Moreau, J., Mokhtari, S., Soavi, M. J., Faucher, O., Ménard, A., Orticoni, M., PoizotMartin, I., Soavi, M. J., Atoui, N., Baillat, V., Faucherre, V., Favier, C., Jacquet, J. M., Le Moing, V, Makinson, A., Mansouri, R., Merle, C., Elforzli, N., Allavena, C., Aubry, O., Besnier, M., Billaud, E., Bonnet, B., Bouchez, S., Boutoille, D., Brunet, C., Feuillebois, N., Lefebvre, M., MorineauLe Houssine, P, Mounoury, O., Point, P., Raffi, F., Reliquet, V., Talarmin, J. P., Ceppi, C., Cua, E., Dellamonica, P., De SalvadorGuillouet, Durant, J., Ferrando, S., MondainMiton, V., Perbost, I., Pillet, S., ProuvostKeller, B., Pradier, C., Pugliese, P., Roger, P. M., Rosenthal, E., Sanderson, F., Hocqueloux, L., Niang, M., Prazuck, T., Arsac, P., BarraultAnstett, M.F., Ahouanto, M., Bouvet, E., Castanedo, G., CharloisOu, C., Dia Kotuba, A., EidAntoun, Z., Jestin, C., Jidar, K., Joly, V., KhuongJosses, M. A., Landgraf, N., Landman, R., Lariven, S., Leprêtre, A., Lʼhériteau, F., Machado, M., Matheron, S., Michard, F., Morau, G., Pahlavan, G., Phung, B. C., Prévot, M. H., Rioux, C., Yéni, P., BaniSadr, F., Calboreanu, A., Chakvetadze, E., Salmon, D., Silbermann, B., Batisse, D., Beumont, M., Buisson, M., Castiel, P., Derouineau, J., Eliaszewicz, M., Gonzalez, G., Jayle, D., Karmochkine, M., Kousignian, P., Pavie, J., Pierre, I., Weiss, L., Badsi, E., Bendenoun, M., Cervoni, J., Diemer, M., Durel, A., Rami, A., Sellier, P., AitMohand, H., Amirat, N., Bonmarchand, M., Bourdillon, F., Breton, G., Caby, F., Grivois, J. P., Katlama, C., Kirstetter, M., Paris, L., Pichon, F., Roudière, L., Schneider, L., Samba, M. C., Seang, S., Simon, A., Stitou, H., Tubiana, R., Valantin, M. A., Bollens, D., Bottero, J., Bui, E., Campa, P., Fonquernie, L., Fournier, S., Girard, P. M., Goetschel, A., Guyon, H. F., Lacombe, K., Lallemand, F., Lefebvre, B., Maynard, J. L., Meyohas, M. C., Ouazene, Z., Pacanowski, J., Picard, O., Raguin, G., Roussard, P., Tourneur, M., Tredup, J., Valin, N., Balkan, S., Clavel, F., Colin de Verdière, N, De Castro, N., de Lastours, V., Ferret, S., Gallien, S., Garrait, V., Gérard, L., Goguel, J., Lafaurie, M., LascouxCombe, C., Molina, J. M., Oksenhendler, E., Pavie, J., Pintado, C., Ponscarme, D., Rozenbaum, W., Scemla, A., Bonnard, P., Lassel, L., Lebrette, M. G., Lyavanc, T., Mariot, P., Missonnier, R., Ohayon, M., Pialoux, G., Treilhou, M. P., Vincensini, J. P., Gilquin, J., Hadacek, B., NaitIghil, L., Nguyen, T. H., Pintado, C., Sobel, A., Viard, J. P., Zak Dit Zbar, O., Aumaître, H., Eden, A., Ferreyra, M., Lopez, F., Medus, M., Neuville, S., Saada, M., Blum, L., Perfezou, P., Arvieux, C., Chapplain, J. M., Revest, M., Souala, F., Tattevin, P., Bord, S., BorsaLebas, F., Caron, F., Chapuzet, C., Debab, Y., Gueit, I., Etienne, M., Fartoukh, C., Feltgen, K., Joly, C., RobadayVoisin, S., Suel, P., Khuong, M. A., Krausse, J., Poupard, M., Tran Van, G., Cazorla, C., Daoud, F., Fascia, P., Frésard, A., Guglielminotti, C., Lucht, F., BernardHenry, C., Cheneau, C., Lang, J. M., de Mautort, E., Partisani, M., Priester, M., Rey, D., Majerholc, C., Zucman, D., Assi, A., Lafeuillade, A., de Jaureguiberry, J. P., Gisserot, O., Aquilina, C., Prevoteau du Clary, F., Alvarez, M., Chauveau, M., Cuzin, L., Delobel, P., Garipuy, D., Labau, E., Marchou, B., Massip, P., Mularczyk, M., Obadia, M., Ajana, F., Allienne, C., Baclet, V., de la Tribonnière, X, Huleux, T., Melliez, H., Meybeck, A., Riff, B., Valette, M., Viget, N., Bastides, F., Bernard, L., Gras, G., Guadagnin, P., May, T., Rabaud, C., Dos Santos, A, P oinsignon, Y., Derradji, O., Escaut, L., Teicher, E., Vittecoq, D., Bantsima, J., CarauxPaz, P., and Patey, O.

Published
2017
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19. The consequences of COVID-19 pandemic on patients with monoclonal gammopathy-associated systemic capillary leak syndrome (Clarkson disease)

Author

Marc Pineton de Chambrun, Quentin Moyon, Stanislas Faguer, Geoffrey Urbanski, Alexis Mathian, Noémie Zucman, Marie Werner, Charles-Edouard Luyt, Franco Verlicchi, Zahir Amoura, Marie Gousseff, Wladimir Mauhin, Arnaud Hot, Jean-Christophe Lega, Marc Lambert, Sophie Riviere, Antoine Dossier, Marc Ruivard, François Lhote, Gilles Blaison, Sybille Merceron, Nathalie Zapella, Laurent Alric, Christian Agard, Mathieu Lacout, David Saadoun, Julie Graveleau, Martin Soubrier, Julien Haroche, Julien Boileau, Marie-Josee Lucchini-Lecomte, Thomas Hanslik, Christine Christides, Hervé Levesque, Aline Talasczka, Caroline Bulte, Eric Hachulla, Olivier Decaux, Romain Sonneville, Florent Ibouanga, Bertrand Arnulf, Marcel Benedit, Jean François Viallard, Nathalie Tieulie, Fadi Haddad, Bruno Moulin, Fleur Cohen-Aubert, Pierre-Yves Lovey, Sylvie le Moal, Béatrice Bibes, Georges-Etienne Rivard, Eric Rondeau, Giuseppe Malizia, Philippe Debourdeau, Pierre Abgueguen, Annick Bosseray, Jérôme Devaquet, Claire Presne, François Liferman, Nicolas Limal, Laurent Argaud, Romain Hernu, Sylvie de la Salle, Jorge Álvarez Troncoso, John Harty, Pascal Godmer, Miguel Hie, Thomas Papo, and Pierre-Yves Hatron

Subjects
SARS-CoV-2, systemic capillary-leak syndrome, Paraproteinemias, Immunology and Allergy, COVID-19, Humans, Clinical Communications, Clarkson’s disease, vaccination, Pandemics, Capillary Leak Syndrome
Published
2021

21. Étude de la discordance des diagnostics infectieux entre les urgences et les services de médecine interne au CHUGA : recherche de facteurs prédictifs et évaluation d’impact

Author

M. Vangout, L. Bouillet, A. Bosseray, D. Viglino, P. Dumanoir, and A. Bocquet

Subjects
Gynecology, medicine.medical_specialty, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Gastroenterology, Internal Medicine, medicine, business
Abstract

Introduction : Les hospitalisations pour motif infectieux en medecine interne via les urgences representent une part importante du nombre total d’hospitalisations. Les urgentistes posent un diagnostic initial qui influence le deroulement du traitement apres l'admission. Des discordances avec le diagnostic de sortie de medecine interne sont decrites dans la litterature, avec de potentielles consequences medicales et economiques. Cette etude, centree sur les patients avec un diagnostic preliminaire ou definitif d’origine infectieuse, a pour objectif principal d’evaluer le taux de discordance diagnostique entre le diagnostic evoque aux urgences et celui retenu en medecine interne. Les objectifs secondaires sont d’identifier les facteurs associes a ces ecarts de diagnostic et d’en mesurer les consequences. Materiel et Methode : Nous avons realise une etude retrospective monocentrique sur les patients hospitalises en medecine interne au Centre Hospitalier Grenoble Alpes, via un service d’urgence, du 22 mars 2021 au 22 juin 2021 inclus, avec un diagnostic evoque d’infection aux urgences et/ou retenu a la fin de leur hospitalisation en medecine interne. Nous avons determine s'il y avait une difference entre le type d’infection evoque a la sortie des urgences et le type d’infection retenu a la sortie du service de medecine interne, permettant de definir la discordance diagnostique. Les caracteristiques intrinseques des patients, liees au passage aux urgences et les caracteristiques hospitalieres de morbi-mortalite ont ete recueillies afin d’etudier leur association a la discordance diagnostique. Resultats : Sur la periode d’inclusion, 559 patients ont ete hospitalises en medecine interne, dont 280 provenaient des urgences et avaient un diagnostic infectieux retenu aux urgences et/ou en medecine interne. Il s’agissait principalement d’hommes (59,3%), avec une mediane d’âge de 80 ans, un score de Charlson superieur a 6 et une prise de 7 medicaments par jour. Une infection COVID etait le diagnostic en sortie d’hospitalisation de medecine interne chez un peu moins d’un tiers des patients inclus. Une discordance diagnostique a ete retrouvee chez 65 des 280 patients inclus soit 23,2%. Elle concernait principalement, parmi les diagnostics poses aux urgences, des diagnostics etiquetes d’origine non infectieuse (26 patients), des infections respiratoires (14 patients) et des infections urinaires (4 patients). Parmi les caracteristiques intrinseques des patients associees a une discordance diagnostique, on note un âge plus eleve (p-value 0,01) et un score de Charlson plus important (p-value 0,034). Parmi les caracteristiques du passage aux urgences, on retrouve un temps de passage plus long aux urgences (p-value 0,016). La conclusion a une infection COVID en fin d’hospitalisation de medecine interne etait associee de maniere significative a l’absence de discordance diagnostique (p-value < 0,001). Concernant l’etude de l’impact, on met en evidence une association statistiquement significative avec l’arret de l’antibiotherapie a l’arrivee dans le service (p-value < 0,0001). Conclusion : La discordance diagnostique est un probleme de sante publique qui affecte tous les services de l’hopital mais aussi la medecine ambulatoire. L’integration des connaissances actuelles dans notre pratique, ainsi que la multiplication d’etudes robustes sur la prevalence et la recherche des facteurs causals sont necessaires en vue de l’elaboration d'etudes interventionnelles.

Published
2021
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23. Screening of hepatitis E in patients presenting for acute neurological disorders

Author

Sébastien Lhomme, Chantal Dumestre-Pérard, Vincent Leroy, Lorella Minotti, Emeline Lagrange, Patrice Morand, Jean-Luc Bosson, M. Lugosi, Claire Wintenberger, Roselyne Collomb-Muret, Aude Belbézier, Maxime Maignan, Damien Viglino, Françoise Sarrot-Reynauld, Sylvie Larrat, Perrine Dumanoir, Isabelle Boccon-Gibod, Alban Deroux, Carole Schwebel, A. Bosseray, Antoine Vilotitch, Mathieu Vaillant, Julien Lupo, Laurence Bouillet, Olivier Epaulard, B. Colombe, Clinique de médecine interne, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Centre Hospitalier Universitaire [Grenoble] (CHU), Pôle Psychiatrie et Neurologie [Grenoble], Service d'immunologie [CHU Grenoble], CHU de Grenoble, Centre de Physiopathologie Toulouse Purpan (CPTP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Virologie [Toulouse], CHU Toulouse [Toulouse], Département de virologie [Grenoble], Institut de biologie structurale (IBS - UMR 5075), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), Radiopharmaceutiques biocliniques (LRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 (TIMC ), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Biologie du Cancer et de l'Infection (BCI ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Virologie [CHU Toulouse], Institut Fédératif de Biologie (IFB), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Pôle Biologie [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), and Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications Grenoble - UMR 5525 (TIMC-IMAG)

Subjects
0301 basic medicine, Male, viruses, Neurological disorder, medicine.disease_cause, Serology, Hepatitis, 0302 clinical medicine, Hepatitis E virus, Seroepidemiologic Studies, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, 030212 general & internal medicine, Prospective Studies, Acute hepatitis, MESH: Acute Disease / epidemiology, Adult, Aged, Aged, 80 and over, Brachial Plexus Neuritis / epidemiology, Female, France / epidemiology, Guillain-Barre Syndrome / epidemiology, Hepatitis Antibodies / blood, Hepatitis E / blood, Hepatitis E / diagnosis, Hepatitis E / epidemiology, Hepatitis E / immunology, Hepatitis E virus / immunology, Humans Immunoglobulin M / blood, Middle Aged, Nervous System Diseases / epidemiology, Nervous System Diseases / immunology, RNA, Viral / blood, Reverse Transcriptase Polymerase Chain Reaction, Transaminases / blood, Young Adult, education.field_of_study, lcsh:Public aspects of medicine, virus diseases, General Medicine, Hepatitis E, 3. Good health, Infectious Diseases, Acute Disease, RNA, Viral, France, medicine.medical_specialty, 030106 microbiology, Population, Guillain-Barre Syndrome, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Internal medicine, medicine, Seroprevalence, Brachial Plexus Neuritis, Humans, lcsh:RC109-216, Hepatitis Antibodies, education, Transaminases, business.industry, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, medicine.disease, Immunoglobulin M, Elevated transaminases, Nervous System Diseases, business
Abstract

International audience; Introduction: Hepatitis E virus (HEV) infection has been reported to be associated with neurological disor-ders. However, the real prevalence of acute hepatitis E in those diseases is still unknown. We determinedthe prevalence of anti-HEV IgM antibody in a population with acute non-traumatic, non-metabolic,non-vascular neurological injury.Method: A registry was created in Grenoble Hospital University from 2014 to 2018 to collect data onpatients with acute (

Published
2020
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25. Screening of hepatitis E in patients presenting for acute neurological disorders

Author

Belbézier, Aude, primary, Deroux, Alban, additional, Sarrot-Reynauld, Françoise, additional, Colombe, Barbara, additional, Bosseray, Annick, additional, Wintenberger, Claire, additional, Dumanoir, Perrine, additional, Lugosi, Maxime, additional, Boccon-Gibod, Isabelle, additional, Leroy, Vincent, additional, Maignan, Maxime, additional, Collomb-Muret, Roselyne, additional, Viglino, Damien, additional, Vaillant, Mathieu, additional, Minotti, Lorella, additional, Lagrange, Emeline, additional, Epaulard, Olivier, additional, Dumestre-Perard, Chantal, additional, Lhomme, Sébastien, additional, Lupo, Julien, additional, Larrat, Sylvie, additional, Morand, Patrice, additional, Schwebel, Carole, additional, Vilotitch, Antoine, additional, Bosson, Jean-Luc, additional, and Bouillet, Laurence, additional

Published
2020
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33. Hepatitis E Virus in Acute Non-Traumatic, Non-Vascular Neurological Injury: A French Monocentric Prospective Study

Author

aude belbézier, Alban Deroux, Françoise Sarrot-Reynauld, Barbara Colombe, Annick Bosseray, Claire Wintenberger, Perrine Dumanoir, Maxime Lugosi, Isabelle Boccond-Gibod, Vincent Leroy, Maxime Maignan, Roselyne Collomb-Muret, Damien Viglino, Mathieu Vaillant, Emeline Lagrange, Olivier Epaulard, Chantal Dumestre-Perard, Julien Lupo, Sylvie Larrat, Patrice Morand, Carole Schwebel, Antoine Vilotitch, Jean-Luc Bosson, and Laurence Bouillet

Published
2018
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34. Hepatitis E Virus in Acute Non-Traumatic, Non-Vascular Neurological Injury: A French Monocentric Prospective Study

Author

Claire Wintenberger, Maxime Maignan, Damien Viglino, Olivier Epaulard, Sylvie Larrat, Carole Schwebel, Françoise Sarrot-Reynauld, B. Colombe, Chantal Dumestre-Pérard, Lorella Minotti, Emeline Lagrange, Isabelle Boccond-Gibod, Alban Deroux, Maxime Lugosi, Laurence Bouillet, Perrine Dumanoir, Patrice Morand, A. Bosseray, Roselyne Collomb-Muret, Vincent Leroy, Jean-Luc Bosson, Julien Lupo, Antoine Vilotitch, Mathieu Vaillant, and Aude Belbézier

Subjects
medicine.medical_specialty, Neurological injury, Hepatitis E virus, business.industry, Non traumatic, Internal medicine, Medicine, business, Prospective cohort study, medicine.disease_cause
Published
2018
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35. Adding Azathioprine to Remission-Induction Glucocorticoids for Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss), Microscopic Polyangiitis, or Polyarteritis Nodosa Without Poor Prognosis Factors

Author

Puechal, Xavier, Pagnoux, Christian, Baron, Gabriel, Quemeneur, Thomas, Néel, Antoine, Agard, Christian, Lifermann, François, Liozon, Eric, Ruivard, Marc, Godmer, Pascal, Limal, Nicolas, Mekinian, Arsène, Papo, Thomas, Ruppert, Anne, Bourgarit, Anne, Bienvenu, Boris, Geffray, Loïc, Saraux, Luc, Diot, Elisabeth, Crestani, Bruno, Delbrel, Xavier, Sailler, Laurent, Cohen, Pascal, Le Guern, Véronique, Terrier, Benjamin, Groh, Matthieu, Le Jeunne, Claire, Mouthon, Luc, Ravaud, Philippe, Guillevin, Loïc, Pineton de Chambrun, Marc, Luyt, Charles-Edouard, Beloncle, Francois, Gousseff, Marie, Mauhin, Wladimir, Argaud, Laurent, Ledochowski, Stanislas, Moreau, Anne-Sophie, Sonneville, Romain, Verdière, Bruno, Merceron, Sybille, Zappella, Nathalie, Landais, Mickael, Contou, Damien, Demoule, Alexandre, Paulus, Sylvie, Souweine, Bertrand, Lecomte, Bernard, Vieillard-Baron, Antoine, Terzi, Nicolas, Azoulay, Elie, Friolet, Raymond, Puidupin, Marc, Devaquet, Jérôme, Mazou, Jean-Marc, Fédun, Yannick, Mira, Jean-Paul, Raphalen, Jean-Herlé, Combes, Alain, Amoura, Zahir, Lega, Jean-Christophe, Lambert, Marc, Rivière, Sophie, Dossier, Antoine, Lhote, François, Blaison, Gilles, Alric, Laurent, Saadoun, David, Graveleau, Julie, Soubrier, Martin, Lecomte, Marie-Josée, Christides, Christine, Bosseray, Annick, Lévesque, Hervé, Viallard, François, Tieulie, Nathalie, Lovey, Pierre-Yves, Le Moal, Sylvie, Bibes, Béatrice, Malizia, Giuseppe, Abgueguen, Pierre, Liferman, François, Ninet, Jacques, Hatron, Pierre-Yves, Hot, Arnaud, Hernu, Romain, de La Salle, Sylvie, Similowski, Thomas, Haroche, Julien, Boileau, Julien, Hanslik, Thomas, Bulte, Caroline, Talasczka, Aline, Hachulla, Eric, Decaux, Olivier, Ibouanga, Florent, Arnulf, Bertrand, Benedit, Marc, Maalouf, Assaad, Moulin, Bruno, Cohen-Aubart, Fleur, Pha, Micheline, Rivard, Georges-Etienne, Rondeau, Eric, Debourdeau, Philippe, Presne, Claire, Andrieu, Maude, Len Abad, Oscar, Devilliers, Hervé, Rogers, Alister, Hie, Miguel, Mathian, Alexis, Heidelberger, Valentine, Ingen-Housz-Oro, Saskia, Marquet, Alicia, Mahevas, Matthieu, Bessis, Didier, Bouillet, Laurence, Caux, Frédéric, Chapelon-Abric, Catherine, Debarbieux, Sebastien, Delaporte, Emmanuel, Duval-Modeste, Anne-Bénédicte, Fain, Olivier, Joly, Pascal, Marchand-Adam, Marc, Monfort, Jean-Benoît, Noel, Nicolas, Passeron, Thierry, Sarrot-Reynauld, Françoise, Verrot, Denis, Bouvry, Diane, Fardet, Laurence, Chosidow, Olivier, Sève, Pascal, Valeyre, Dominique, Moreau, Sophie, Centre Hospitalier Le Mans (CH Le Mans), Service de médecine interne et centre de référence des maladies rares [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Modèles et méthodes de l'évaluation thérapeutique des maladies chroniques (U738 / UMR_S738), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7), Département de Médecine Interne (VALENCIENNES - Med Int), CH Valenciennes, Service de médecine interne [Nantes], Université de Nantes (UN)-Hôtel-Dieu-Centre hospitalier universitaire de Nantes (CHU Nantes), Service de Médecine Interne [Dax], Centre Hospitalier de Dax, Service de Médecine interne A et polyclinique médicale [CHU Limoges], CHU Limoges, CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand, Service de médecine interne [CHU Bretagnes Atlantique], CHU Bretagnes Atlantique, Service de rhumatologie [CHU Saint-Antoine], CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Department of Internal Medicine, Université Paris Diderot - Paris 7 (UPD7), Centre d'Immunologie et de Maladies Infectieuses (CIMI), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Médecine interne, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Physiopathologie et Epidemiologie de l'Insuffisance Respiratoire, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Médecine Interne [Pau], Centre hospitalier de Pau, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Immunologie - Immunopathologie - Immunothérapeutique (I3), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service des maladies infectieuses et tropicales, Université Paris Diderot - Paris 7 (UPD7)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Chirurgie Orthopédique et traumatique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Centre de référence pour les vascularites nécrosantes et la sclérodermie systémique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Faculté de Médecine-pôle de Médecine Interne, CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de Réanimation Médicale et de Médecine Hyperbare [Angers], Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Institut Pasteur de Madagascar, Réseau International des Instituts Pasteur (RIIP), Centre de recherche en myologie, Université Pierre et Marie Curie - Paris 6 (UPMC)-Association française contre les myopathies (AFM-Téléthon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), Ecole Polytechnique Fédérale de Lausanne (EPFL), Hôpital Bichat - Claude Bernard, Service de soins intensifs, Centre Hospitalier de Versailles André Mignot (CHV), Service de réanimation médicale, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Neurophysiologie Respiratoire Expérimentale et Clinique, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Microorganismes : Génome et Environnement (LMGE), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Centre National de la Recherche Scientifique (CNRS)-Université d'Auvergne - Clermont-Ferrand I (UdA), Médecine générale, Service de réanimation medico-chirurgicale [CHU Raymond-Poincaré], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Ambroise Paré [AP-HP], Service de réanimation médicale [CHU Caen], Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Université de Caen Normandie (UNICAEN), Normandie Université (NU), Medical ICU, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Service d'anesthésie-réanimation SAMU94-SMUR94 [Mondor], Institut Cochin (UMR_S567 / UMR 8104), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Immunité et Infection, Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR113-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Montpellier (CHU Montpellier ), Centre National de la Recherche Scientifique (CNRS), Hôpital pasteur [Colmar], Service de Medecine Interne, CHU Toulouse [Toulouse]-Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse], Centre hospitalier de Saint-Nazaire, Clinique de médecine interne, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Service de Médecine Interne [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Hôpital l'Archet, Service des maladies infectieuses et tropicales [CHU Angers], Médecine Interne Dax (MEDECINE INTERNE), Hopital, Service de Médecine Interne, Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Service de médecine interne [Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service de Pneumologie et Réanimation Médicale [CHU Pitié-Salpêtrière] (Département ' R3S '), CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de médecine interne [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Department of Clinical Immunology, CHU Strasbourg, CHU Pontchaillou [Rennes], Service d'hématologie biologique, Service de néphrologie, Service de médecine interne et d'immunologie clinique [CHU Pitié-Salpêtrière], Service d'Hématologie-Oncologie, Hôpital Ste-Justine, Département d'Oncologie (Dep Oncol - AVIGNON), Institut Ste Catherine, Service de Néphrologie - Médecine Interne, CHU Amiens-Picardie-hôpital Sud, Service de Médecine Interne (SOC 1 et SOC 2) [CHU de Dijon], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), CHU Henri Mondor, Service de Médecine Interne [Henri Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Centre de référence maladie rare des cytopénies auto-immunes de l'adulte-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Service de Dermatologie, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Service de dermatologie [Avicenne], Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris 13 (UP13), Service de Dermatologie, Centre Hospitalier Sud, Hospices Civils, Lyon, Service de dermatologie (CHRU de Lille), Service de dermatologie [Rouen], Service de médecine interne, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Jean Verdier [AP-HP], Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université Paris Descartes - Faculté de Médecine (UPD5 Médecine), Université Paris Descartes - Paris 5 (UPD5), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Equipe 12, Centre Hospitalier Universitaire de Nice (CHU Nice)-Hôpital l'Archet-Centre Hospitalier Universitaire de Nice (CHU Nice)-Hôpital l'Archet-Centre méditerranéen de médecine moléculaire (C3M), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), Service de pneumologie [Avicenne], Service de médecine interne [Saint-Antoine], Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Epidemiology in Dermatology and Evaluation in Therapeutics (EpiDermE), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Centre de recherche en Myologie – U974 SU-INSERM, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Centre National de la Recherche Scientifique (CNRS), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Service Médecine interne [CHU Toulouse], Pôle Inflammation, infection, immunologie et loco-moteur [CHU Toulouse] (Pôle I3LM Toulouse), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), CHU Henri Mondor [Créteil], Université Paris 13 (UP13)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (1965 - 2019) (UNS), Hôpital Ambroise Paré [AP-HP]-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR113-Université Pierre et Marie Curie - Paris 6 (UPMC), Service de Département de médecine interne et immunologie clinique [CHU Pitié-Salpêtrière] (DMIIC), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Service de médecine interne [CHU Saint-Antoine]

Subjects
[SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience

Published
2017
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36. Uncommon and fatal case of cystoisosporiasis in a non HIV-immunosuppressed patient from a non-endemic country

Author

Lucie Post, Annick Bosseray, Hervé Pelloux, Cécile Garnaud, Danièle Maubon, Catherine Mansard, and Céline Dard

Subjects
Diarrhea, Pediatrics, medicine.medical_specialty, Acute decompensated heart failure, 030231 tropical medicine, Isosporiasis, 03 medical and health sciences, Feces, Immunocompromised Host, 0302 clinical medicine, Fatal Outcome, Acquired immunodeficiency syndrome (AIDS), Food Parasitology, Cystoisosporiasis, Communicable Diseases, Imported, Trimethoprim, Sulfamethoxazole Drug Combination, Medicine, Humans, Aged, biology, Isospora, business.industry, Transmission (medicine), Oocysts, medicine.disease, biology.organism_classification, Infectious Diseases, Methotrexate, Immunology, Coccidiostats, 030211 gastroenterology & hepatology, Parasitology, Cystoisospora belli, Female, France, medicine.symptom, business, Immunosuppressive Agents
Abstract

Cystoisospora belli (previously known as Isospora belli) is a tropical coccidian parasite sometimes leading to severe diarrhea in immunocompromised patients. Here we describe a fatal case of cystoisosporiasis in a non HIV-immunocompromised 71-year-old female with no recent travel history. Infection was either latent or potentially caused by the consumption of contaminated imported food from Asia. Diagnosis was made by microscopical detection of numerous C. belli oocysts in stools without specific staining. Treatment with TMP-SMZ slightly improved diarrhea within 3days, but dehydration subsequently led to acute decompensated heart failure and a fatal evolution. This report illustrates the possibility of severe cystoisosporiasis in non HIV-immunocompromised patients in a non-endemic country and highlights the risk of transmission through imported contaminated food consumption.

Published
2017

37. Thrombosis and antiphospholipid antibody syndrome during acute Q fever

Author

Million, Matthieu, Bardin, Nathalie, Bessis, Simon, Nouiakh, Nadia, Douliery, Charlaine, Edouard, Sophie, Angelakis, Emmanouil, Bosseray, Annick, Epaulard, Olivier, Branger, Stéphanie, Chaudier, Bernard, Blanc-Laserre, Karine, Ferreira-Maldent, Nicole, Demonchy, Élisa, Roblot, France, Reynes, Jacques, Djossou, Félix, Protopopescu, Camelia, Carrieri, Patrizia, Camoin-Jau, Laurence, Mege, Jean-Louis, Raoult, Didier, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, INSB-INSB-Centre National de la Recherche Scientifique (CNRS), Vascular research center of Marseille (VRCM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU), CHU Grenoble, Hôpital d'Instruction des Armées Laveran, Service de Santé des Armées, Centre hospitalier de Valence, Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Centre Hospitalier Universitaire de Nice (CHU Nice), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U912 INSERM - Aix Marseille Univ - IRD), Institut de Recherche pour le Développement (IRD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU), ORS PACA, Laboratoire d'hématologie biologique [Hôpital de la Timone - Hôpital Nord - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Pharmacologie des anti-infectieux (PHAR), Université de Poitiers-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Herrada, Anthony

Subjects
Adult, Male, Adolescent, Observational Study, Enzyme-Linked Immunosorbent Assay, Young Adult, Surveys and Questionnaires, Humans, Child, Q fever, thrombosis, Aged, Aged, 80 and over, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, antiphospholipid antibodies, Middle Aged, Antiphospholipid Syndrome, infection, Cross-Sectional Studies, Logistic Models, ROC Curve, Coxiella burnetii, Antibodies, Anticardiolipin, Immunoglobulin G, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Female, France, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Research Article, Follow-Up Studies
Abstract

Supplemental Digital Content is available in the text, Q fever is a neglected and potentially fatal disease. During acute Q fever, antiphospholipid antibodies are very prevalent and have been associated with fever, thrombocytopenia, acquired heart valve disease, and progression to chronic endocarditis. However, thrombosis, the main clinical criterion of the 2006 updated classification of the antiphospholipid syndrome, has not been assessed in this context. To test whether thrombosis is associated with antiphospholipid antibodies and whether the criteria for antiphospholipid syndrome can be met in patients with acute Q fever, we conducted a cross-sectional study at the French National Referral Center for Q fever. Patients included were diagnosed with acute Q fever in our Center between January 2007 and December 2015. Each patient's history and clinical characteristics were recorded with a standardized questionnaire. Predictive factors associated with thrombosis were assessed using a rare events logistic regression model. IgG anticardiolipin antibodies (IgG aCL) assessed by an enzyme-linked immunosorbent assay were tested on the Q fever diagnostic serum. A dose-dependent relationship between IgG aCL levels and thrombosis was tested using a receiver operating characteristic (ROC) analysis. Of the 664 patients identified for inclusion in the study, 313 (47.1%) had positive IgG aCL and 13 (1.9%) were diagnosed with thrombosis. Three patients fulfilled the antiphospholipid syndrome criteria. After multiple adjustments, only positive IgG aCL (relative risk, 14.46 [1.85–113.14], P = .011) were independently associated with thrombosis. ROC analysis identified a dose-dependent relationship between IgG aCL levels and occurrence of thrombosis (area under curve, 0.83, 95%CI [0.73–0.93], P

Published
2017
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41. Intravenous Immunoglobulins Improve Survival in Monoclonal Gammopathy-Associated Systemic Capillary-Leak Syndrome

Author

Marc Pineton de Chambrun, Marie Gousseff, Wladimir Mauhin, Jean-Christophe Lega, Marc Lambert, Sophie Rivière, Antoine Dossier, Marc Ruivard, François Lhote, Gilles Blaison, Laurent Alric, Christian Agard, David Saadoun, Julie Graveleau, Martin Soubrier, Marie-Josée Lucchini-Lecomte, Christine Christides, Annick Bosseray, Hervé Levesque, Jean-François Viallard, Nathalie Tieulie, Pierre-Yves Lovey, Sylvie Le Moal, Béatrice Bibes, Giuseppe Malizia, Pierre Abgueguen, François Lifermann, Jacques Ninet, Pierre-Yves Hatron, Zahir Amoura, Arnaud Hot, Laurent Argaud, Romain Hernu, Sylvie de la Salle, Stanislas Ledochowski, Anne-Sophie Moreau, Thomas Papo, Romain Sonneville, Bruno Verdière, Sybille Merceron, Nathalie Zappella, Mickael Landais, Nicolas Limal, Damien Contou, Thomas Similowski, Alexandre Demoule, Bertrand Souweine, Julien Haroche, Julien Boileau, Bernard Lecomte, Thomas Hanslik, Antoine Vieillard-Baron, Nicolas Terzi, Caroline Bulte, Aline Talasczka, Eric Hachulla, Olivier Decaux, Florent Ibouanga, Bertrand Arnulf, Matthieu Groh, Elie Azoulay, Marcel Benedit, Assaad Maalouf, Bruno Moulin, Fleur Cohen-Aubart, Raymond Friolet, Sylvie le Moal, Micheline Pha, Georges-Etienne Rivard, Eric Rondeau, Philippe Debourdeau, Marc Puidupin, François Beloncle, Jérôme Devaquet, Claire Presne, François Liferman, Jean-Marc Mazou, Maude Andrieu, Sylvie Paulus, Yannick Fedun, Jean-Paul Mira, Jean-Herlé Raphalen, Oscar Len Abad, Hervé Devilliers, Alister Rogers, Pascal Godmer, Charles-Edouard Luyt, Alain Combes, Miguel Hie, Alexis Mathian, CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Pasteur de Madagascar, Réseau International des Instituts Pasteur (RIIP), Centre de recherche en myologie, Université Pierre et Marie Curie - Paris 6 (UPMC)-Association française contre les myopathies (AFM-Téléthon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hospices Civils de Lyon (HCL), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Hospitalier Universitaire de Montpellier (CHU Montpellier ), Centre d'Immunologie et de Maladies Infectieuses (CIMI), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Pascal (IP), SIGMA Clermont (SIGMA Clermont)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS), Department of Internal Medicine, Hôpital pasteur [Colmar], CHU Toulouse [Toulouse], Service de médecine interne [Nantes], Université de Nantes (UN)-Hôtel-Dieu-Centre hospitalier universitaire de Nantes (CHU Nantes), Immunologie - Immunopathologie - Immunothérapeutique (I3), Centre hospitalier de Saint-Nazaire, CHU Clermont-Ferrand, Centre hospitalier d'Ajaccio, Centre Hospitalier Henri Duffaut (Avignon), Clinique de médecine interne, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Service de Médecine Interne [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), IHU-LIRYC, Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux], Hôpital l'Archet, Centre Hospitalier du Valais Romand [Sion, Switzerland], CHU de Saint-Brieuc, CHP Saint Grégoire, Service des maladies infectieuses et tropicales [CHU Angers], Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Médecine Interne Dax (MEDECINE INTERNE), Hopital, Service de Médecine Interne, Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Service de médecine interne [Lille], Immunité et Infection, Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR113-Institut National de la Santé et de la Recherche Médicale (INSERM), Analyse Comparée des Pouvoirs (ACP), Université Paris-Est Marne-la-Vallée (UPEM), Université Paris Diderot - Paris 7 (UPD7), Hôpital Bichat - Claude Bernard, Service de soins intensifs, Centre Hospitalier de Versailles André Mignot (CHV), Service de réanimation médicale, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Service de Pneumologie et Réanimation Médicale [CHU Pitié-Salpêtrière] (Département ' R3S '), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Neurophysiologie Respiratoire Expérimentale et Clinique, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Microorganismes : Génome et Environnement (LMGE), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Centre National de la Recherche Scientifique (CNRS), Service de médecine interne [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Department of Clinical Immunology, CHU Strasbourg, Médecine générale, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Ambroise Paré [AP-HP], Service de réanimation medico-chirurgicale [CHU Raymond-Poincaré], Service de réanimation médicale [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), CHU Pontchaillou [Rennes], Service d'hématologie biologique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Service des maladies infectieuses et tropicales, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Medical ICU, Service de néphrologie, Service de Département de médecine interne et immunologie clinique [CHU Pitié-Salpêtrière] (DMIIC), Service d'Hématologie-Oncologie, Hôpital Ste-Justine, Département d'Oncologie (Dep Oncol - AVIGNON), Institut Ste Catherine, Service de Réanimation Médicale et de Médecine Hyperbare [Angers], Service d'anesthésie-réanimation SAMU94-SMUR94 [Mondor], Service de Néphrologie - Médecine Interne, CHU Amiens-Picardie-hôpital Sud, Institut Cochin (UMR_S567 / UMR 8104), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de Médecine Interne (SOC 1 et SOC 2) [CHU de Dijon], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Service de médecine interne [CHU Bretagnes Atlantique], CHU Bretagnes Atlantique, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de recherche en Myologie – U974 SU-INSERM, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), SIGMA Clermont (SIGMA Clermont)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Service de Medecine Interne, CHU Toulouse [Toulouse]-Hôpital Purpan [Toulouse], Pharmacochimie et Biologie pour le Développement (PHARMA-DEV), Institut de Recherche pour le Développement (IRD)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Centre National de la Recherche Scientifique (CNRS)-Université d'Auvergne - Clermont-Ferrand I (UdA), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Université de Caen Normandie (UNICAEN), Université Paris Diderot - Paris 7 (UPD7)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), and Service de médecine interne et d'immunologie clinique [CHU Pitié-Salpêtrière]

Subjects
Male, medicine.medical_specialty, Paraproteinemias, Context (language use), Intravenous immunoglobulins, Monoclonal gammopathy-associated systemic capillary-leak syndrome, Systemic capillary-leak syndrome, 030204 cardiovascular system & hematology, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Theophylline, Interquartile range, Internal medicine, medicine, Terbutaline, Systemic capillary leak syndrome, Humans, 030212 general & internal medicine, Multiple myeloma, Clarkson disease, business.industry, Hazard ratio, Immunoglobulins, Intravenous, [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology, General Medicine, Middle Aged, medicine.disease, Survival Analysis, 3. Good health, Surgery, Cohort, Monoclonal, Female, business, Capillary Leak Syndrome, Cohort study
Abstract

International audience; Background: Monoclonal gammopathy-associated systemic capillary-leak syndrome, also known as Clarkson disease, is a rare condition characterized by recurrent life-threatening episodes of capillary hyperpermeability in the context of a monoclonal gammopathy. This study was conducted to better describe the clinical characteristics, natural history, and long-term outcome of monoclonal gammopathy-associated systemic capillary-leak syndrome.Methods: We conducted a cohort analysis of all patients included in the European Clarkson disease (EurêClark) registry between January 1997 and March 2016. From diagnosis to last follow-up, studied outcomes (eg, the frequency and severity of attacks, death, and evolution toward multiple myeloma) and the type of preventive treatments administered were monitored every 6 months.Results: Sixty-nine patients (M/F sex ratio 1:1; mean ± SD age at disease onset 52 ± 12 years) were included in the study. All patients had monoclonal gammopathy of immunoglobulin G type, with kappa light chains in 47 (68%). Median (interquartile range) follow-up duration was 5.1 (2.5-9.7) years. Twenty-four patients (35%) died after 3.3 (0.9-8) years. Fifty-seven (86%) patients received at least one preventive treatment, including intravenous immunoglobulins (IVIg) n = 48 (73.8%), theophylline n = 22 (33.8%), terbutaline n = 22 (33.8%), and thalidomide n = 5 (7.7%). In the 65 patients with follow-up, 5- and 10-year survival rates were 78% (n = 35) and 69% (n = 17), respectively. Multivariate analysis found preventive treatment with IVIg (hazard ratio 0.27; 95% confidence interval, 0.10-0.70; P = .007) and terbutaline (hazard ratio 0.35; 95% confidence interval, 0.13-0.96; P = .041) to be independent predictors of mortality.Conclusions: We describe the largest cohort to date of patients with well-defined monoclonal gammopathy-associated systemic capillary-leak syndrome. Preventive treatment with IVIg was the strongest factor associated with survival, suggesting the use of IVIg as the first line in prevention therapy.

Published
2016
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42. Organising pneumonia and mesenteric plasmocytoma: A fortuitous association?

Author

C. Massot, Alban Deroux, Emilie Berthoux, A. Bosseray, Sylvain Carras, and B. Colombe

Subjects
Pathology, medicine.medical_specialty, Tomography x ray computed, medicine.anatomical_structure, business.industry, Medicine, Radionuclide imaging, General Medicine, business, Mesentery, Organising pneumonia, Cryptogenic Organizing Pneumonia
Published
2012
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44. Unusual Evolution in Wegener's Granulomatosis: Recovery of Pulmonary Involvement While Renal Disease Progressed to End-Stage

Author

B. Colombe, Leonidas Chavez, Marc Padilla, Emilie Berthoux, A. Bosseray, and C. Massot

Subjects
Lung Diseases, Male, medicine.medical_specialty, Pathology, urologic and male genital diseases, Critical Care and Intensive Care Medicine, Gastroenterology, Internal medicine, medicine, Humans, Rapidly progressive glomerulonephritis, Anti-neutrophil cytoplasmic antibody, medicine.diagnostic_test, business.industry, Granulomatosis with Polyangiitis, Acute kidney injury, Glomerulonephritis, Diffuse alveolar hemorrhage, General Medicine, Middle Aged, medicine.disease, Otitis, Nephrology, Disease Progression, Kidney Failure, Chronic, Renal biopsy, medicine.symptom, business, Polyneuropathy
Abstract

A 54-year-old male patient was admitted for acute respiratory distress with fever. He was suffering from chronic sinusitis/rhinitis and had persistent otitis for the past 2 months before admission despite several antibiotics courses. He developed a complex pulmonary involvement (embolism and diffuse alveolar hemorrhage) with acute glomerular disease (proteinuria and hematuria but initially no renal failure). Clinical suspicion of Wegener's granulomatosis was confirmed by the positive high titer of antineutrophil cytoplasmic antibodies (c-ANCA with antiproteinase 3 specificity) and despite a negative nasal biopsy. Treatment including cyclophosphamide and methylprednisolone intravenous pulses permitted pulmonary recovery over 4 weeks contrasting with the development of rapidly progressive glomerulonephritis and polyneuropathy of lower limbs. Renal biopsy showed pauci-immune crescentic and necrotizing glomerulonephritis. However, despite additional plasma exchanges, acute kidney injury worsened and the patient ended up in dialysis. Such a dissociated evolution was unexpected in this case since pulmonary and renal involvements reflected the same pathological process (small vessels vasculitis/capillaritis) and the same pathogenic mechanism (antiproteinase 3 autoantibodies).

Published
2011
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45. La maladie de Whipple : une cause curable d’encéphalite

Author

Brieuc Gestin, Claire Wintenberger, A. Bosseray, B. Colombe, C. Massot, and Sylvie Grand

Subjects
Gynecology, 0303 health sciences, medicine.medical_specialty, biology, 030306 microbiology, business.industry, Whipple Disease, Gastroenterology, biology.organism_classification, medicine.disease, 3. Good health, Tropheryma whipplei, Intestinal malabsorption, 03 medical and health sciences, 0302 clinical medicine, Internal Medicine, medicine, 030212 general & internal medicine, Whipple's disease, business, Encephalitis
Abstract

Resume Introduction La maladie de Whipple est une granulomatose systemique rare et de diagnostic parfois difficile. Observation Nous rapportons une observation de maladie de Whipple dont la presentation initiale etait une encephalite aigue. La realisation de multiples prelevements a la recherche d’une maladie de Whipple a conduit au diagnostic, alors que la polymerase chain reaction (PCR) Tropheryma whipplei sur le liquide cephalorachidien etait negative et la biopsie cerebrale stereotaxique recusee. L’evolution sous antibiotherapie adaptee a ete consideree comme « spectaculaire ». Conclusion La maladie de Whipple est une cause rare d’encephalite. Le diagnostic repose sur la realisation de la PCR specifique sur divers prelevements, et sur l’histologie. L’evolution sous antibiotherapie adaptee peut etre tres favorable.

Published
2011
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47. Hepatitis E Virus in Acute Non-Traumatic, Non-Vascular Neurological Injury: A French Monocentric Prospective Study

Author

belbézier, aude, primary, Deroux, Alban, additional, Sarrot-Reynauld, Françoise, additional, Colombe, Barbara, additional, Bosseray, Annick, additional, Wintenberger, Claire, additional, Dumanoir, Perrine, additional, Lugosi, Maxime, additional, Boccond-Gibod, Isabelle, additional, Leroy, Vincent, additional, Maignan, Maxime, additional, Collomb-Muret, Roselyne, additional, Viglino, Damien, additional, Vaillant, Mathieu, additional, Lagrange, Emeline, additional, Epaulard, Olivier, additional, Dumestre-Perard, Chantal, additional, Lupo, Julien, additional, Larrat, Sylvie, additional, Morand, Patrice, additional, Schwebel, Carole, additional, Vilotitch, Antoine, additional, Bosson, Jean-Luc, additional, and Bouillet, Laurence, additional

Published
2018
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48. Hepatitis E and neuralgic amyotrophy: Five cases and review of literature

Author

Sylvie Larrat, Françoise Sarrot-Reynauld, Anaïs Dartevel, Emmeline Lagrange, B. Colombe, Laurence Bouillet, A. Bosseray, Aude Belbézier, Université Grenoble Alpes - UFR Médecine (UGA UFRM), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Clinique de médecine interne, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Unit for Virus Host-Cell Interactions [Grenoble] (UVHCI), Université Joseph Fourier - Grenoble 1 (UJF)-European Molecular Biology Laboratory [Grenoble] (EMBL)-Centre National de la Recherche Scientifique (CNRS), Département de neurologie, and Centre National de la Recherche Scientifique (CNRS)-European Molecular Biology Laboratory [Grenoble] (EMBL)-Université Joseph Fourier - Grenoble 1 (UJF)

Subjects
Parsonage–Turner syndrome, Adult, Male, Pediatrics, medicine.medical_specialty, Usually asymptomatic, Sex Factors, MESH: Sex Factors, Virology, medicine, Brachial Plexus Neuritis, Humans, Parsonage turner syndrome, MESH: Brachial Plexus Neuritis, MESH: Developed Countries, Neuralgic amyotrophy, MESH: Humans, MESH: Middle Aged, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], Acute hepatitis E, business.industry, Developed Countries, MESH: Hepatitis E, Mean age, Strong hepatitis E, MESH: Adult, Middle Aged, Hepatitis E, medicine.disease, Nervous system diseases, MESH: Immunoglobulin M, MESH: Male, 3. Good health, Surgery, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM], Infectious Diseases, Immunoglobulin M, Female, business, Brachial plexus, MESH: Female, Hepatitis E virus infection
Abstract

International audience; Hepatitis E virus infection - mainly genotype 3 - is increasingly common in industrialized countries. Infection is usually asymptomatic, but cases of central or peripheral neurological symptoms with hepatitis E have been described. The most frequent is Guillain-Barre but somes cases of neuralgic amyotrophy have been described. In our center, since 2010, we have identified five cases of neuralgic amyotrophy associated with acute hepatitis E in immunocompetent patients. For all these patients, neuralgic amyotrophy was diagnosed with electromyogram and positive IgM for hepatitis E, and detectable HEV RNA in 4 of the cases. Including our patients, we count 26 cases in literature. The mean age of the patients was 44 years old, with a large predominance of males (88%). The disorder is bilateral and asymmetric in 69% of cases. Peripheral nerves other than the brachial plexus were affected in 6 patients (23%). In industrialized countries, any neuralgic amyotrophy, particularly if there is bilateral, asymmetric associated with involvement of nerves outside the brachial plexus, should lead physicians to consider a diagnosis of acute hepatitis E.

Published
2015
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49. Treatment of imported malaria in adults: a multicentre study in France

Author

A Bosseray, Jean Delmont, R. Laganier, J. Gaillat, B. Marchou, Hervé Tissot-Dupont, Denis Malvy, P. Brouqui, Stéphane Ranque, Jean-Paul Stahl, C. Cazorla, A. Lotte, Albert Sotto, J. Durant, Eric Adehossi, J.-M. Ragneau, and S. Dydymsky

Subjects
Adult, Pediatrics, medicine.medical_specialty, Antimalarials, chemistry.chemical_compound, Halofantrine, medicine, Humans, Malaria, Falciparum, Practice Patterns, Physicians', Medical prescription, business.industry, Mefloquine, Tropical disease, General Medicine, Emigration and Immigration, medicine.disease, Discontinuation, Regimen, Cross-Sectional Studies, Treatment Outcome, chemistry, Practice Guidelines as Topic, Propensity score matching, Emergency medicine, France, Guideline Adherence, business, Malaria, medicine.drug
Abstract

Summary Background: Data about anti-malarial drugs prescription practices in Europe and the safety of imported malaria treatments are scanty. In 1999, a French consensus development conference published guidelines for the prevention and treatment of imported P. falciparum malaria. The impact of these guidelines has not been evaluated. Aim: To investigate the impact of these guidelines on the prescription of anti-malarials, and to evaluate the incidence of acute drug events (ADEs) leading to discontinuation of treatment. Design: Cross-sectional survey. Methods: Members of the medical staff in 14 French infectious and tropical disease wards completed a standardized form for each patient treated for imported malaria in 2001. A propensity score matching technique was used to estimate the risk of ADEs leading to discontinuation of the regimen. Results: In the 474 patients studied, quinine was the first-line anti-malarial most often prescribed. Only 3% of patients received halofantrine. Mefloquine was associated with a RR of 4.9 (95%CI 3.2–7.4, p50.00001) risk of discontinuation of treatment due to ADEs. Discussion: The very limited use of halofantrine indicates that the main practice recommendations of the guidelines have been taken into account. Mefloquine was associated with a substantial risk of discontinuing the treatment because of ADEs. This is a serious limitation for the use of mefloquine in the treatment of out-patients with imported malaria.

Published
2005
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