137 results on '"A. Cruz-Bermudez"'
Search Results
2. BRAF mutational status is associated with survival outcomes in locally advanced resectable and metastatic NSCLC
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Provencio, Mariano, Robado de Lope, Lucía, Serna-Blasco, Roberto, Nadal, Ernest, Diz Tain, Pilar, Massuti, Bartomeu, González-Larriba, José Luis, Insa, Amelia, Sánchez-Hernández, Alfredo, Casal-Rubio, Joaquín, García-Campelo, Rosario, Sequero López, Silvia, Rogado, Jacobo, Martínez-Martí, Alex, Bosch-Barrera, Joaquim, Bernabé, Reyes, Vázquez Estévez, Sergio, Ponce, Santiago, de Castro, Javier, Coves Sarto, Juan, Reguart, Noemí, Dómine, Manuel, Aguilar, Andrés, Majem, Margarita, Estival, Anna, Peña Cabia, Silvia, López Martín, Ana, Sala González, María Ángeles, Cobo, Manuel, Camps, Carlos, Barneto, Isidoro, Calvo, Virginia, Collazo-Lorduy, Ana, Cruz-Bermúdez, Alberto, and Romero, Atocha
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- 2024
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3. Clinical phenotypes and outcomes in children with multisystem inflammatory syndrome across SARS-CoV-2 variant eras: a multinational study from the 4CE consortium
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Aaron, James R., Adam, Atif, Agapito, Giuseppe, Albayrak, Adem, Albi, Giuseppe, Alessiani, Mario, Alloni, Anna, Amendola, Danilo F., Angoulvant, François, Anthony, Li LLJ., Aronow, Bruce J., Ashraf, Fatima, Atz, Andrew, Avillach, Paul, Panickan, Vidul Ayakulangara, Azevedo, Paula S., Badenes, Rafael, Balshi, James, Batugo, Ashley, Beaulieu-Jones, Brendin R., Beaulieu-Jones, Brett K., Bell, Douglas S., Bellasi, Antonio, Bellazzi, Riccardo, Benoit, Vincent, Beraghi, Michele, Bernal-Sobrino, José Luis, Bernaux, Mélodie, Bey, Romain, Bhatnagar, Surbhi, Blanco-Martínez, Alvar, Boeker, Martin, Bonzel, Clara-Lea, Booth, John, Bosari, Silvano, Bourgeois, Florence T., Bradford, Robert L., Brat, Gabriel A., Bréant, Stéphane, Brown, Nicholas W., Bruno, Raffaele, Bryant, William A., Bucalo, Mauro, Bucholz, Emily, Burgun, Anita, Cai, Tianxi, Cannataro, Mario, Carmona, Aldo, Cattelan, Anna Maria, Caucheteux, Charlotte, Champ, Julien, Chen, Jin, Chen, Krista Y., Chiovato, Luca, Chiudinelli, Lorenzo, Cho, Kelly, Cimino, James J., Colicchio, Tiago K., Cormont, Sylvie, Cossin, Sébastien, Craig, Jean B., Cruz-Bermúdez, Juan Luis, Cruz-Rojo, Jaime, Dagliati, Arianna, Daniar, Mohamad, Daniel, Christel, Das, Priyam, Devkota, Batsal, Dionne, Audrey, Duan, Rui, Dubiel, Julien, DuVall, Scott L., Esteve, Loic, Estiri, Hossein, Fan, Shirley, Follett, Robert W., Ganslandt, Thomas, García-Barrio, Noelia, Garmire, Lana X., Gehlenborg, Nils, Getzen, Emily J., Geva, Alon, Goh, Rachel SJ., González, Tomás González, Gradinger, Tobias, Gramfort, Alexandre, Griffier, Romain, Griffon, Nicolas, Grisel, Olivier, Gutiérrez-Sacristán, Alba, Guzzi, Pietro H., Han, Larry, Hanauer, David A., Haverkamp, Christian, Hazard, Derek Y., He, Bing, Henderson, Darren W., Hilka, Martin, Ho, Yuk-Lam, Holmes, John H., Honerlaw, Jacqueline P., Hong, Chuan, Huling, Kenneth M., Hutch, Meghan R., Issitt, Richard W., Jannot, Anne Sophie, Jouhet, Vianney, Kainth, Mundeep K., Kate, Kernan F., Kavuluru, Ramakanth, Keller, Mark S., Kennedy, Chris J., Kernan, Kate F., Key, Daniel A., Kirchoff, Katie, Klann, Jeffrey G., Kohane, Isaac S., Krantz, Ian D., Kraska, Detlef, Krishnamurthy, Ashok K., L'Yi, Sehi, Leblanc, Judith, Lemaitre, Guillaume, Lenert, Leslie, Leprovost, Damien, Liu, Molei, Will Loh, Ne Hooi, Long, Qi, Lozano-Zahonero, Sara, Luo, Yuan, Lynch, Kristine E., Mahmood, Sadiqa, Maidlow, Sarah E., Makoudjou, Adeline, Makwana, Simran, Malovini, Alberto, Mandl, Kenneth D., Mao, Chengsheng, Maram, Anupama, Maripuri, Monika, Martel, Patricia, Martins, Marcelo R., Marwaha, Jayson S., Masino, Aaron J., Mazzitelli, Maria, Mazzotti, Diego R., Mensch, Arthur, Milano, Marianna, Minicucci, Marcos F., Moal, Bertrand, Ahooyi, Taha Mohseni, Moore, Jason H., Moraleda, Cinta, Morris, Jeffrey S., Morris, Michele, Moshal, Karyn L., Mousavi, Sajad, Mowery, Danielle L., Murad, Douglas A., Murphy, Shawn N., Naughton, Thomas P., Breda Neto, Carlos Tadeu, Neuraz, Antoine, Newburger, Jane, Ngiam, Kee Yuan, Njoroge, Wanjiku FM., Norman, James B., Obeid, Jihad, Okoshi, Marina P., Olson, Karen L., Omenn, Gilbert S., Orlova, Nina, Ostasiewski, Brian D., Palmer, Nathan P., Paris, Nicolas, Patel, Lav P., Pedrera-Jiménez, Miguel, Pfaff, Ashley C., Pfaff, Emily R., Pillion, Danielle, Pizzimenti, Sara, Priya, Tanu, Prokosch, Hans U., Prudente, Robson A., Prunotto, Andrea, Quirós-González, Víctor, Ramoni, Rachel B., Raskin, Maryna, Rieg, Siegbert, Roig-Domínguez, Gustavo, Rojo, Pablo, Romero-Garcia, Nekane, Rubio-Mayo, Paula, Sacchi, Paolo, Sáez, Carlos, Salamanca, Elisa, Samayamuthu, Malarkodi Jebathilagam, Sanchez-Pinto, L. Nelson, Sandrin, Arnaud, Santhanam, Nandhini, Santos, Janaina C.C., Sanz Vidorreta, Fernando J., Savino, Maria, Schriver, Emily R., Schubert, Petra, Schuettler, Juergen, Scudeller, Luigia, Sebire, Neil J., Serrano-Balazote, Pablo, Serre, Patricia, Serret-Larmande, Arnaud, Shah, Mohsin A., Hossein Abad, Zahra Shakeri, Silvio, Domenick, Sliz, Piotr, Son, Jiyeon, Sonday, Charles, South, Andrew M., Sperotto, Francesca, Spiridou, Anastasia, Strasser, Zachary H., Tan, Amelia LM., Tan, Bryce W.Q., Tan, Byorn W.L., Tanni, Suzana E., Taylor, Deanne M., Terriza-Torres, Ana I., Tibollo, Valentina, Tippmann, Patric, Toh, Emma MS., Torti, Carlo, Trecarichi, Enrico M., Vallejos, Andrew K., Varoquaux, Gael, Vella, Margaret E., Verdy, Guillaume, Vie, Jill-Jênn, Visweswaran, Shyam, Vitacca, Michele, Wagholikar, Kavishwar B., Waitman, Lemuel R., Wang, Xuan, Wassermann, Demian, Weber, Griffin M., Wolkewitz, Martin, Wong, Scott, Xia, Zongqi, Xiong, Xin, Ye, Ye, Yehya, Nadir, Yuan, William, Zachariasse, Joany M., Zahner, Janet J., Zambelli, Alberto, Zhang, Harrison G., Zöller, Daniela, Zuccaro, Valentina, Zucco, Chiara, Li, Xiudi, Rofeberg, Valerie N., Elias, Matthew D., Laird-Gion, Jessica, and Newburger, Jane W.
- Published
- 2023
- Full Text
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4. Characterization of long COVID temporal sub-phenotypes by distributed representation learning from electronic health record data: a cohort study
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Aaron, James R., Agapito, Giuseppe, Albayrak, Adem, Albi, Giuseppe, Alessiani, Mario, Alloni, Anna, Amendola, Danilo F., François Angoulvant, Anthony, Li L.L.J., Aronow, Bruce J., Ashraf, Fatima, Atz, Andrew, Avillach, Paul, Azevedo, Paula S., Balshi, James, Beaulieu-Jones, Brett K., Bell, Douglas S., Bellasi, Antonio, Bellazzi, Riccardo, Benoit, Vincent, Beraghi, Michele, Bernal-Sobrino, José Luis, Bernaux, Mélodie, Bey, Romain, Bhatnagar, Surbhi, Blanco-Martínez, Alvar, Bonzel, Clara-Lea, Booth, John, Bosari, Silvano, Bourgeois, Florence T., Bradford, Robert L., Brat, Gabriel A., Bréant, Stéphane, Brown, Nicholas W., Bruno, Raffaele, Bryant, William A., Bucalo, Mauro, Bucholz, Emily, Burgun, Anita, Cai, Tianxi, Cannataro, Mario, Carmona, Aldo, Caucheteux, Charlotte, Champ, Julien, Chen, Jin, Chen, Krista Y., Chiovato, Luca, Chiudinelli, Lorenzo, Cho, Kelly, Cimino, James J., Colicchio, Tiago K., Cormont, Sylvie, Cossin, Sébastien, Craig, Jean B., Cruz-Bermúdez, Juan Luis, Cruz-Rojo, Jaime, Dagliati, Arianna, Daniar, Mohamad, Daniel, Christel, Das, Priyam, Devkota, Batsal, Dionne, Audrey, Duan, Rui, Dubiel, Julien, DuVall, Scott L., Esteve, Loic, Estiri, Hossein, Fan, Shirley, Follett, Robert W., Ganslandt, Thomas, Barrio, Noelia García, Garmire, Lana X., Gehlenborg, Nils, Getzen, Emily J., Geva, Alon, Gradinger, Tobias, Gramfort, Alexandre, Griffier, Romain, Griffon, Nicolas, Grisel, Olivier, Gutiérrez-Sacristán, Alba, Han, Larry, Hanauer, David A., Haverkamp, Christian, Hazard, Derek Y., He, Bing, Henderson, Darren W., Hilka, Martin, Ho, Yuk-Lam, Holmes, John H., Hong, Chuan, Huling, Kenneth M., Hutch, Meghan R., Issitt, Richard W., Jannot, Anne Sophie, Jouhet, Vianney, Kavuluru, Ramakanth, Keller, Mark S., Kennedy, Chris J., Key, Daniel A., Kirchoff, Katie, Klann, Jeffrey G., Kohane, Isaac S., Krantz, Ian D., Kraska, Detlef, Krishnamurthy, Ashok K., L'Yi, Sehi, Le, Trang T., Leblanc, Judith, Lemaitre, Guillaume, Lenert, Leslie, Leprovost, Damien, Liu, Molei, Will Loh, Ne Hooi, Long, Qi, Lozano-Zahonero, Sara, Luo, Yuan, Lynch, Kristine E., Mahmood, Sadiqa, Maidlow, Sarah E., Makoudjou, Adeline, Malovini, Alberto, Mandl, Kenneth D., Mao, Chengsheng, Maram, Anupama, Martel, Patricia, Martins, Marcelo R., Marwaha, Jayson S., Masino, Aaron J., Mazzitelli, Maria, Mensch, Arthur, Milano, Marianna, Minicucci, Marcos F., Moal, Bertrand, Ahooyi, Taha Mohseni, Moore, Jason H., Moraleda, Cinta, Morris, Jeffrey S., Morris, Michele, Moshal, Karyn L., Mousavi, Sajad, Mowery, Danielle L., Murad, Douglas A., Murphy, Shawn N., Naughton, Thomas P., Breda Neto, Carlos Tadeu, Neuraz, Antoine, Newburger, Jane, Ngiam, Kee Yuan, Njoroge, Wanjiku F.M., Norman, James B., Obeid, Jihad, Okoshi, Marina P., Olson, Karen L., Omenn, Gilbert S., Orlova, Nina, Ostasiewski, Brian D., Palmer, Nathan P., Paris, Nicolas, Patel, Lav P., Pedrera-Jiménez, Miguel, Pfaff, Emily R., Pfaff, Ashley C., Pillion, Danielle, Pizzimenti, Sara, Prokosch, Hans U., Prudente, Robson A., Prunotto, Andrea, Quirós-González, Víctor, Ramoni, Rachel B., Raskin, Maryna, Rieg, Siegbert, Roig-Domínguez, Gustavo, Rojo, Pablo, Rubio-Mayo, Paula, Sacchi, Paolo, Sáez, Carlos, Salamanca, Elisa, Samayamuthu, Malarkodi Jebathilagam, Sanchez-Pinto, L. Nelson, Sandrin, Arnaud, Santhanam, Nandhini, Santos, Janaina C.C., Sanz Vidorreta, Fernando J., Savino, Maria, Schriver, Emily R., Schubert, Petra, Schuettler, Juergen, Scudeller, Luigia, Sebire, Neil J., Serrano-Balazote, Pablo, Serre, Patricia, Serret-Larmande, Arnaud, Shah, Mohsin, Hossein Abad, Zahra Shakeri, Silvio, Domenick, Sliz, Piotr, Son, Jiyeon, Sonday, Charles, South, Andrew M., Spiridou, Anastasia, Strasser, Zachary H., Tan, Amelia L.M., Tan, Bryce W.Q., Tan, Byorn W.L., Tanni, Suzana E., Taylor, Deanne M., Terriza-Torres, Ana I., Tibollo, Valentina, Tippmann, Patric, Toh, Emma M.S., Torti, Carlo, Trecarichi, Enrico M., Tseng, Yi-Ju, Vallejos, Andrew K., Varoquaux, Gael, Vella, Margaret E., Verdy, Guillaume, Vie, Jill-Jênn, Visweswaran, Shyam, Vitacca, Michele, Wagholikar, Kavishwar B., Waitman, Lemuel R., Wang, Xuan, Wassermann, Demian, Weber, Griffin M., Wolkewitz, Martin, Wong, Scott, Xia, Zongqi, Xiong, Xin, Ye, Ye, Yehya, Nadir, Yuan, William, Zambelli, Alberto, Zhang, Harrison G., Zo¨ller, Daniela, Zuccaro, Valentina, Zucco, Chiara, Mesa, Rebecca, and Verdy, Guillame
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- 2023
- Full Text
- View/download PDF
5. Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19
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Abdukahil, heryl Ann, Abdulkadir, Nurul Najmee, Abe, Ryuzo, Abel, Laurent, Abrous, Amal, Absil, Lara, Acker, Andrew, Adachi, Shingo, Adrião, Diana, Al Ageel, Saleh, Ahmed, Shakeel, Ainscough, Kate, Airlangga, Eka, Aisa, Tharwat, Hssain, Ali Ait, Tamlihat, Younes Ait, Akimoto, Takako, Akmal, Ernita, Akwani, Chika, Al Qasim, Eman, Alalqam, Razi, Alberti, Angela, Al-dabbous, Tala, Alegesan, Senthilkumar, Alessi, Marta, Alex, Beatrice, Alexandre, Kévin, Al-Fares, Abdulrahman, Alfoudri, Huda, Ali, Imran, Alidjnou, Kazali Enagnon, Aliudin, Jeffrey, Alkhafajee, Qabas, Allavena, Clotilde, Allou, Nathalie, Alves, João, Alves, Rita, Alves, João Melo, Cabrita, Joana Alves, Amaral, Maria, Amira, Nur, Ampaw, Phoebe, Andini, Roberto, Andréjak, Claire, Angheben, Andrea, Angoulvant, François, Ansart, Séverine, Anthonidass, Sivanesen, Antonelli, Massimo, Antunes de Brito, Carlos Alexandre, Apriyana, Ardiyan, Arabi, Yaseen, Aragao, Irene, Arancibia, Francisco, Araujo, Carolline, Arcadipane, Antonio, Archambault, Patrick, Arenz, Lukas, Arlet, Jean-Benoît, Arnold-Day, Christel, Arora, Lovkesh, Arora, Rakesh, Artaud-Macari, Elise, Aryal, Diptesh, Asensio, Angel, Ashraf, Muhammad, Assie, Jean Baptiste, Asyraf, Amirul, Atif, Minahel, Atique, Anika, Auchabie, Johann, Aumaitre, Hugues, Auvet, Adrien, Azemar, Laurène, Azoulay, Cecile, Bach, Benjamin, Bachelet, Delphine, Badr, Claudine, Baillie, J. Kenneth, Baird, J Kevin, Bak, Erica, Bakakos, Agamemnon, Bakar, Nazreen Abu, Bal, Andriy, Balakrishnan, Mohanaprasanth, Balan, Valeria, Bani-Sadr, Firouzé, Barbalho, Renata, Barbosa, Nicholas Yuri, Barclay, Wendy S., Barnett, Saef Umar, Barnikel, Michaela, Barrelet, Audrey, Barrigoto, Cleide, Bartoli, Marie, Baruch, Joaquín, Basmaci, Romain, Hassin Basri, Muhammad Fadhli, Battaglini, Denise, Bauer, Jules, Bautista Rincon, Diego Fernando, Beane, Abigail, Bedossa, Alexandra, Bee, Ker Hong, Begum, Husna, Behilill, Sylvie, Beishuizen, Albertus, Beljantsev, Aleksandr, Bellemare, David, Beltrame, Anna, Beltrão, Beatriz Amorim, Beluze, Marine, Benech, Nicolas, Benjiman, Lionel Eric, Benkerrou, Dehbia, Bennett, Suzanne, Benny, Binny, Bento, Luís, Berdal, Jan-Erik, Bergeaud, Delphine, Bergin, Hazel, Bernal Sobrino, José Luis, Bertoli, Giulia, Bertolino, Lorenzo, Bessis, Simon, Bevilcaqua, Sybille, Bezulier, Karine, Bhatt, Amar, Bhavsar, Krishna, Bianco, Claudia, Bidin, Farah Nadiah, Singh, Moirangthem Bikram, Humaid, Felwa Bin, Bin Kamarudin, Mohd Nazlin, Bisoffi, Zeno, Bissuel, François, Biston, Patrick, Bitker, Laurent, Bitton, Jonathan, Blanco-Schweizer, Pablo, Blier, Catherine, Bloos, Frank, Blot, Mathieu, Blumberg, Lucille, Boccia, Filomena, Bodenes, Laetitia, Bogaert, Debby, Boivin, Anne-Hélène, Bolaños, Isabela, Bolze, Pierre-Adrien, Bompart, François, Borges, Diogo, Borie, Raphaël, Botelho-Nevers, Elisabeth, Bouadma, Lila, Bouchaud, Olivier, Bouchez, Sabelline, Bouhmani, Dounia, Bouhour, Damien, Bouiller, Kévin, Bouillet, Laurence, Bouisse, Camile, Boureau, Anne-Sophie, Bourke, John, Bouscambert, Maude, Bousquet, Aurore, Bouziotis, Jason, Boxma, Bianca, Boyer-Besseyre, Marielle, Boylan, Maria, Bozza, Fernando Augusto, Braconnier, Axelle, Braga, Cynthia, Monteiro, Filipa Brás, Brazzi, Luca, Breen, Patrick, Breen, Dorothy, Brewster, David, Brickell, Kathy, Browne, Shaunagh, Brusse-Keizer, Marjolein, Bryda, Petra, Buchtele, Nina, Bugaeva, Polina, Buisson, Marielle, Burhan, Erlina, Burrell, Aidan, Bustos, Ingrid G., Butnaru, Denis, Cabie, André, Cabral, Susana, Caceres, Eder, Cadoz, Cyril, Garcês, Rui Caetano, Calligy, Kate, Calvache, Jose Andres, Camões, João, Campana, Valentine, Campbell, Paul, Campisi, Josie, Cantero, Mireia, Caraux-Paz, Pauline, Cardellino, Chiara Simona, Cardoso, Sofia, Cardoso, Filipe, Cardoso, Filipa, Cardoso, Nelson, Carelli, Simone, Carlier, Nicolas, Carmoi, Thierry, Carney, Gayle, Carqueja, Inês, Carret, Marie-Christine, Carrier, François Martin, Carroll, Ida, Carson, Gail, Casanova, Maire-Laure, Cascão, Mariana, Casey, Siobhan, Casimiro, José, Cassandra, Bailey, Castanheira, Nidyanara, Castor-Alexandre, Guylaine, Castro, Ivo, Catarino, Ana, Catherine, François-Xavier, Cattaneo, Paolo, Cavalin, Roberta, Cavayas, Alexandros, Cervantes-Gonzalez, Minerva, Chair, Anissa, Chakveatze, Catherine, Chan, Adrienne, Chand, Meera, Chantalat Auger, Christelle, Chapplain, Jean-Marc, Charpentier, Charlotte, Chas, Julie, Chávez Iñiguez, Jonathan Samuel, Chen, Anjellica, Chen, Yih-Sharng, Chenard, Léo, Cheng, Matthew Pellan, Cheret, Antoine, Chiarabini, Thibault, Chica, Julian, Chidambaram, Suresh Kumar, Tho, Leong Chin, Chirouze, Catherine, Chiumello, Davide, Cho, Sung-Min, Cholley, Bernard, Chopin, Marie-Charlotte, Chow, Ting Soo, Chow, Yock Ping, Chua, Hiu Jian, Chua, Jonathan, Cidade, Jose Pedro, Citarella, Barbara Wanjiru, Ciullo, Anna, Clarke, Jennifer, Claure-Del Granado, Rolando, Clohisey, Sara, Cobb, Perren J., Codan, Cassidy, Cody, Caitriona, Coelho, Alexandra, Coles, Megan, Coles, Jennifer, Colin, Gwenhaël, Collins, Michael, Colombo, Sebastiano Maria, Combs, Pamela, Connolly, Jennifer, Connor, Marie, Conrad, Anne, Conway, Elaine, Cooke, Graham S., Copland, Mary, Cordel, Hugues, Corley, Amanda, Cornelis, Sabine, Cornet, Alexander Daniel, Corpuz, Arianne Joy, Cortegiani, Andrea, Corvaisier, Grégory, Couffignal, Camille, Couffin-Cadiergues, Sandrine, Courtois, Roxane, Cousse, Stéphanie, Croonen, Sabine, Crowl, Gloria, Crump, Jonathan, Cruz, Claudina, Cruz Bermúdez, Juan Luis, Rojo, Jaime Cruz, Csete, Marc, Cullen, Ailbhe, Curley, Gerard, Curlier, Elodie, Curran, Colleen, Custodio, Paula, da Silva Filipe, Ana, Da Silveira, Charlene, Dabaliz, Al-Awwab, Dai, Danyang, Dagens, Andrew, Dahly, Darren, Dalton, Heidi, Dalton, Jo, Daly, Seamus, Damas, Juliana, Daneman, Nick, Daniel, Corinne, Dankwa, Emmanuelle A., Dantas, Jorge, de Loughry, Gillian, De Montmollin, Etienne, Freitas de Oliveira França, Rafael, De Rosa, Rosanna, de Silva, Thushan, de Vries, Peter, Dean, David, Debard, Alexa, DeBenedictis, Bianca, Debray, Marie-Pierre, DeCastro, Nathalie, Dechert, William, Deconninck, Lauren, Decours, Romain, Defous, Eve, Delacroix, Isabelle, Delaveuve, Eric, Delavigne, Karen, Dell'Amore, Andrea, Delmas, Christelle, Delobel, Pierre, Delsing, Corine, Demonchy, Elisa, Denis, Emmanuelle, Deplanque, Dominique, Depuydt, Pieter, Desai, Mehul, Descamps, Diane, Desvallées, Mathilde, Dewayanti, Santi, Dhanger, Pathik, Diallo, Alpha, Diamantis, Sylvain, Da Silva, Fernanda Dias, Diaz, Juan Jose, Diaz, Rodrigo, Didier, Kévin, Diehl, Jean-Luc, Dieperink, Wim, Dimet, Jérôme, Dinot, Vincent, Diop, Fara, Diouf, Alphonsine, Dishon, Yael, Djossou, Félix, Docherty, Annemarie B., Doherty, Helen, Donnelly, Maria, Donnelly, Christl A., Donohue, Sean, Donohue, Yoann, Donohue, Chloe, Doran, Peter, Dorival, Céline, D'Ortenzio, Eric, Douglas, James Joshua, Dournon, Nathalie, Downer, Triona, Downey, Joanne, Downing, Mark, Drake, Tom, Driscoll, Aoife, Dryden, Murray, Fonseca, Claudio Duarte, Dubee, Vincent, Dubos, François, Ducancelle, Alexandre, Duculan, Toni, Dudman, Susanne, Duggal, Abhijit, Dunand, Paul, Dunning, Jake, Duplaix, Mathilde, Durante-Mangoni, Emanuele, Durham, Lucian, III, Dussol, Bertrand, Duthoit, Juliette, Duval, Xavier, Dyrhol-Riise, Anne Margarita, Ean, Sim Choon, Echeverria-Villalobos, Marco, Edwards, Eleanor, Egan, Siobhan, El Sanharawi, Mohammed, Elapavaluru, Subbarao, Elharrar, Brigitte, Eloy, Philippine, Elshazly, Tarek, Enderle, Isabelle, Endo, Tomoyuki, Eng, Chan Chee, Engelmann, Ilka, Enouf, Vincent, Epaulard, Olivier, Escher, Martina, Esperatti, Mariano, Esperou, Hélène, Santo, Catarina Espírito, Esposito-Farese, Marina, Estevão, João, Etienne, Manuel, Ettalhaoui, Nadia, Everding, Anna Greti, Evers, Mirjam, Fabre, Marc, Fabre, Isabelle, Faheem, Amna, Fahy, Arabella, Fairfield, Cameron J., Faria, Pedro, Fateena, Hanan, Fatoni, Arie Zainul, Faure, Karine, Favory, Raphaël, Fayed, Mohamed, Feely, Niamh, Feeney, Laura, Fernandes, Jorge, Fernandes, Marília Andreia, Fernandes, Susana, Ferrand, François-Xavier, Devouge, Eglantine Ferrand, Ferrão, Joana, Ferraz, Mário, Ferreira, Sílvia, Ferreira, Bernardo, Ferreira, Benigno, Ferriere, Nicolas, Ficko, Céline, Figueiredo-Mello, Claudia, Fiorda, Juan, Flament, Thomas, Flanagan, Emily, Flateau, Clara, Fletcher, Tom, Florence, Aline-Marie, Florio, Letizia Lucia, Flynn, Deirdre, Foley, Jean, Fomin, Victor, Fonseca, Tatiana, Forsyth, Simon, Foster, Denise, Foti, Giuseppe, Fourn, Erwan, Fowler, Robert A., Fraher, Marianne, Franch-Llasat, Diego, Fraser, John F., Fraser, Christophe, Freire, Marcela Vieira, Ribeiro, Ana Freitas, Friedrich, Caren, Fritz, Ricardo, Fry, Stéphanie, Fuentes, Nora, Fukuda, Masahiro, G, Argin, Gaborieau, Valérie, Gaci, Rostane, Gagliardi, Massimo, Gagnard, Jean-Charles, Gagneux-Brunon, Amandine, Gaião, Sérgio, Skeie, Linda Gail, Gallagher, Phil, Gamble, Carrol, Gani, Yasmin, Garan, Arthur, Garcia, Rebekha, Barrio, Noelia García, Garcia-Gallo, Esteban, Garot, Denis, Garrait, Valérie, Gault, Nathalie, Gavin, Aisling, Gavrylov, Anatoliy, Gaymard, Alexandre, Gebauer, Johannes, Geraud, Eva, Morlaes, Louis Gerbaud, Germano, Nuno, Ghosn, Jade, Giani, Marco, Gibson, Jess, Gigante, Tristan, Gilg, Morgane, Gilroy, Elaine, Giordano, Guillermo, Girvan, Michelle, Gissot, Valérie, Glikman, Daniel, Glybochko, Petr, Gnall, Eric, Goehringer, François, Goffard, Jean-Christophe, Goh, Jin Yi, Golob, Jonathan, Gominet, Marie, Gonzalez, Alicia, Gordon, Patricia, Gorenne, Isabelle, Gormley, Conor, Goubert, Laure, Goujard, Cécile, Goulenok, Tiphaine, Grable, Margarite, Grandin, Edward Wilson, Granier, Pascal, Grasselli, Giacomo, Green, Christopher A., Greenhalf, William, Greffe, Segolène, Grieco, Domenico Luca, Griffee, Matthew, Griffiths, Fiona, Grigoras, Ioana, Groenendijk, Albert, Gruner, Heidi, Gu, Yusing, Guedj, Jérémie, Guego, Martin, Guellec, Dewi, Guerreiro, Daniela, Guery, Romain, Guillaumot, Anne, Guilleminault, Laurent, Guimarães de Castro, Maisa, Guimard, Thomas, Haalboom, Marieke, Haber, Daniel, Habraken, Hannah, Hachemi, Ali, Hadri, Nadir, Hakak, Sheeba, Hall, Adam, Hall, Matthew, Halpin, Sophie, Hamer, Ansley, Hamers, Raph L., Hamidfar, Rebecca, Hammond, Terese, Hammond, Naomi, Han, Lim Yuen, Hao, Kok Wei, Hardwick, Hayley, Harrison, Ewen M., Harrison, Janet, Hartman, Alan, Hashmi, Junaid, Hayes, Ailbhe, Hays, Leanne, Heerman, Jan, Heggelund, Lars, Hendry, Ross, Hennessy, Martina, Hentzien, Maxime, Hernandez, Diana, Hershey, Andrew, Hesstvedt, Liv, Higgins, Eibhlin, Higgins, Dawn, Higgins, Rupert, Hinchion, Rita, Hinton, Samuel, Hiraiwa, Hiroaki, Hitoto, Hikombo, Ho, Antonia, Ho, Yi Bin, Hoctin, Alexandre, Hoffmann, Isabelle, Hoh, Wei Han, Hoiting, Oscar, Holt, Rebecca, Holter, Jan Cato, Horby, Peter, Hoshino, Kota, Houas, Ikram, Hough, Catherine L., Houltham, Stuart, Ming-Yang Hsu, Jimmy, Hulot, Jean-Sébastien, Hurd, Abby, Ijaz, Samreen, Ikram, M. 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Alison M., Meysonnier, Vanina, Meziane, Amina, Mezidi, Mehdi, Michelanglei, Céline, Michelet, Isabelle, Mihelis, Efstathia, Mihnovit, Vladislav, Miller, Jennene, Misnan, Nor Arisah, Mohamed, Tahira Jamal, Eliza Mohamed, Nik Nur, Moin, Asma, Molinos, Elena, Molloy, Brenda, Monahan, Sinead, Mone, Mary, Monteiro, Agostinho, Montes, Claudia, Montrucchio, Giorgia, Moore, Shona C., Moore, Sarah, Cely, Lina Morales, Moro, Lucia, Motherway, Catherine, Motos, Ana, Mouquet, Hugo, Perrot, Clara Mouton, Moyet, Julien, Mudara, Caroline, Muh, Ng Yong, Muhamad, Dzawani, Mullaert, Jimmy, Müller, Fredrik, Müller, Karl Erik, Munblit, Daniel, Murphy, Aisling, Murphy, Lorna, Murray, Patrick, Murris, Marlène, Murthy, Srinivas, Musaab, Himed, Muyandy, Gugapriyaa, Myrodia, Dimitra Melia, Nagpal, Dave, Nagrebetsky, Alex, Narasimhan, Mangala, Narayanan, Nageswaran, Neant, Nadège, Necsoi, Coca, Nekliudov, Nikita, Neto, Raul, Neumann, Emily, Ng, Pauline Yeung, Ng, Wing Yiu, Nghi, Anthony, Nguyen, Duc, Choileain, 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Sandulescu, Oana, Santos, Marlene, Sarfo-Mensah, Shirley, Sarmiento, Iam Claire E., Sarton, Benjamine, Satyapriya, Sree, Satyawati, Rumaisah, Saviciute, Egle, Saw, Yen Tsen, Schaffer, Justin, Schermer, Tjard, Scherpereel, Arnaud, Schneider, Marion, Schroll, Stephan, Schwameis, Michael, Scott, Janet T., Scott-Brown, James, Sedillot, Nicholas, Seitz, Tamara, Selvarajoo, Mageswari, Semaille, Caroline, Semple, Malcolm G., Senian, Rasidah Bt, Senneville, Eric, Sepulveda, Claudia, Sequeira, Filipa, Sequeira, Tânia, Neto, Ary Serpa, Balazote, Pablo Serrano, Shadowitz, Ellen, Shahidan, Syamin Asyraf, Shamsah, Mohammad, Shankar, Anuraj, Sharjeel, Shaikh, Sharma, Pratima, Shaw, Catherine A., Shaw, Victoria, Sheenan, John Robert, Shi, Haixia, Shime, Nobuaki, Shimizu, Hiroaki, Shimizu, Keiki, Shrapnel, Sally, Shum, Hoi Ping, Mohammed, Nassima Si, Siang, Ng Yong, Sibiude, Jeanne, Siddiqui, Atif, Sigfrid, Louise, Sillaots, Piret, Silva, Catarina, Silva, Rogério, Silva, Maria Joao, Lim Heng, Benedict 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Rizo-Topete, Lilia, Pole, Jason D., and Johnson, David W.
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6. Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry
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Abdukahil, Sheryl Ann, Abdulkadir, Nurul Najmee, Abe, Ryuzo, Abel, Laurent, Abrous, Amal, Absil, Lara, Acker, Andrew, Adam, Elisabeth, Adrião, Diana, Al Ageel, Saleh, Ahmed, Shakeel, Ainscough, Kate, Aisa, Tharwat, Hssain, Ali Ait, Tamlihat, Younes Ait, Akimoto, Takako, Akmal, Ernita, Akwani, Chika, Al Qasim, Eman, Alalqam, Razi, Alberti, Angela, Al-dabbous, Tala, Alegesan, Senthilkumar, Alessi, Marta, Alex, Beatrice, Alexandre, Kévin, Al-Fares, Abdulrahman, Alfoudri, Huda, Ali, Imran, Alidjnou, Kazali Enagnon, Aliudin, Jeffrey, Alkhafajee, Qabas, Allavena, Clotilde, Allou, Nathalie, Alves, João, Alves, Rita, Alves, João Melo, Cabrita, Joana Alves, Amaral, Maria, Amira, Nur, Ampaw, Phoebe, Andini, Roberto, Andréjak, Claire, Angheben, Andrea, Angoulvant, François, Ansart, Séverine, Anthonidass, Sivanesen, Antonelli, Massimo, de Brito, Carlos Alexandre Antunes, Apriyana, Ardiyan, Arabi, Yaseen, Aragao, Irene, Arancibia, Francisco, Araujo, Carolline, Arcadipane, Antonio, Archambault, Patrick, Arenz, Lukas, Arlet, Jean-Benoît, Arnold-Day, Christel, Arora, Lovkesh, Arora, Rakesh, Artaud-Macari, Elise, Aryal, Diptesh, Asensio, Angel, Ashraf, Muhammad, Assie, Jean Baptiste, Asyraf, Amirul, Atif, Minahel, Atique, Anika, Auchabie, Johann, Aumaitre, Hugues, Auvet, Adrien, Azemar, Laurène, Azoulay, Cecile, Bach, Benjamin, Bachelet, Delphine, Badr, Claudine, Baig, Nadia, Baillie, J. 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Moirangthem Bikram, Humaid, Felwa Bin, Kamarudin, Mohd Nazlin Bin, Bisoffi, Zeno, Bissuel, François, Bitker, Laurent, Bitton, Jonathan, Blanco-Schweizer, Pablo, Blier, Catherine, Bloos, Frank, Blot, Mathieu, Blumberg, Lucille, Boccia, Filomena, Bodenes, Laetitia, Bogaert, Debby, Boivin, Anne-Hélène, Bolaños, Isabela, Bolze, Pierre-Adrien, Bompart, François, Borges, Diogo, Borie, Raphaël, Bosse, Hans Martin, Botelho-Nevers, Elisabeth, Bouadma, Lila, Bouchaud, Olivier, Bouchez, Sabelline, Bouhmani, Dounia, Bouhour, Damien, Bouiller, Kévin, Bouillet, Laurence, Bouisse, Camile, Boureau, Anne-Sophie, Bourke, John, Bouscambert, Maude, Bousquet, Aurore, Bouziotis, Jason, Boxma, Bianca, Boyer-Besseyre, Marielle, Boylan, Maria, Bozza, Fernando Augusto, Braconnier, Axelle, Braga, Cynthia, Brandenburger, Timo, Monteiro, Filipa Brás, Brazzi, Luca, Breen, Patrick, Breen, Dorothy, Brewster, David, Brickell, Kathy, Browne, Shaunagh, Browne, Alex, Brozzi, Nicolas, Brusse-Keizer, Marjolein, Bryda, Petra, Buchtele, Nina, Buisson, Marielle, Burhan, Erlina, Burrell, Aidan, Bustos, Ingrid G., Cabie, André, Cabral, Susana, Caceres, Eder, Cadoz, Cyril, Garcês, Rui Caetano, Calligy, Kate, Calvache, Jose Andres, Camões, João, Campana, Valentine, Campbell, Paul, Campisi, Josie, Canepa, Cecilia, Cantero, Mireia, Caraux-Paz, Pauline, Cárcel, Sheila, Cardellino, Chiara Simona, Cardoso, Sofia, Cardoso, Filipe, Cardoso, Filipa, Cardoso, Nelson, Carelli, Simone, Carlier, Nicolas, Carmoi, Thierry, Carney, Gayle, Carqueja, Inês, Carret, Marie-Christine, Carrier, François Martin, Carroll, Ida, Carson, Gail, Casanova, Maire-Laure, Cascão, Mariana, Casey, Siobhan, Casimiro, José, Cassandra, Bailey, Castañeda, Silvia, Castanheira, Nidyanara, Castor-Alexandre, Guylaine, Castro, Ivo, Catarino, Ana, Catherine, François-Xavier, Cattaneo, Paolo, Cavalin, Roberta, Cavayas, Alexandros, Cervantes-Gonzalez, Minerva, Chair, Anissa, Chakveatze, Catherine, Chan, Adrienne, Chand, Meera, Chantalat Auger, Christelle, Chapplain, Jean-Marc, Charpentier, Charlotte, Chas, Julie, Chávez Iñiguez, Jonathan Samuel, Chen, Anjellica, Chen, Yih-Sharng, Chenard, Léo, Cheng, Matthew Pellan, Cheret, Antoine, Chiarabini, Thibault, Chica, Julian, Chidambaram, Suresh Kumar, Chin Tho, Leong, Chirouze, Catherine, Chiumello, Davide, Cho, Sung-Min, Cholley, Bernard, Chopin, Marie-Charlotte, Chow, Ting Soo, Chua, Hiu Jian, Chua, Jonathan, Cidade, Jose Pedro, Cisneros Herreros, José Miguel, Citarella, Barbara Wanjiru, Ciullo, Anna, Clarke, Jennifer, Clarke, Emma, Claure-Del Granado, Rolando, Clohisey, Sara, Codan, Cassidy, Cody, Caitriona, Coelho, Alexandra, Coles, Megan, Coles, Jennifer, Colin, Gwenhaël, Collins, Michael, Colombo, Sebastiano Maria, Combs, Pamela, Connolly, Jennifer, Connor, Marie, Conrad, Anne, Conway, Elaine, Cooke, Graham S., Copland, Mary, Cordel, Hugues, Corley, Amanda, Cornelis, Sabine, Cornet, Alexander Daniel, Corpuz, Arianne Joy, Cortegiani, Andrea, Corvaisier, Grégory, Costigan, Emma, Couffignal, Camille, Couffin-Cadiergues, Sandrine, Courtois, Roxane, Cousse, Stéphanie, Cregan, Rachel, Cristella, Cosimo, Croonen, Sabine, Crowl, Gloria, Crump, Jonathan, Cruz, Claudina, Cruz Bermúdez, Juan Luis, Cruz Rojo, Jaime, Csete, Marc, Cullen, Ailbhe, Cummings, Matthew, Curley, Gerard, Curlier, Elodie, Curran, Colleen, Custodio, Paula, da Silva Filipe, Ana, Da Silveira, Charlene, Dabaliz, Al-Awwab, Dagens, Andrew, Dahly, Darren, Dalton, Heidi, Dalton, Jo, Daly, Seamus, Damas, Juliana, Daneman, Nick, Daniel, Corinne, Dankwa, Emmanuelle A., Dantas, Jorge, D'Aragon, Frédérick, de Jong, Menno, de Loughry, Gillian, De Montmollin, Etienne, de Oliveira França, Rafael Freitas, de Pinho Oliveira, Ana Isabel, De Rosa, Rosanna, de Silva, Thushan, de Vries, Peter, Dean, David, Debard, Alexa, DeBenedictis, Bianca, Debray, Marie-Pierre, DeCastro, Nathalie, Dechert, William, Deconninck, Lauren, Decours, Romain, Defous, Eve, Delacroix, Isabelle, Delaveuve, Eric, Delavigne, Karen, Delfos, Nathalie M., Deligiannis, Ionna, Dell'Amore, Andrea, Delmas, Christelle, Delobel, Pierre, Delsing, Corine, Demonchy, Elisa, Denis, Emmanuelle, Deplanque, Dominique, Depuydt, Pieter, Desai, Mehul, Descamps, Diane, Desvallées, Mathilde, Dewayanti, Santi, Dhanger, Pathik, Diallo, Alpha, Diamantis, Sylvain, Dias, André, Da Silva, Fernanda Dias, Diaz, Juan Jose, Diaz, Rodrigo, Diaz, Priscila, Didier, Kévin, Diehl, Jean-Luc, Dieperink, Wim, Dimet, Jérôme, Dinot, Vincent, Diop, Fara, Diouf, Alphonsine, Dishon, Yael, Djossou, Félix, Docherty, Annemarie B., Doherty, Helen, Donnelly, Maria, Donnelly, Christl A., Donohue, Sean, Donohue, Yoann, Donohue, Chloe, Doran, Peter, Dorival, Céline, D'Ortenzio, Eric, Douglas, James Joshua, Dournon, Nathalie, Downer, Triona, Downey, Joanne, Downing, Mark, Drake, Tom, Driscoll, Aoife, Dryden, Murray, Fonseca, Claudio Duarte, Dubee, Vincent, Dubos, François, Ducancelle, Alexandre, Duculan, Toni, Dudman, Susanne, Duggal, Abhijit, Dunand, Paul, Dunning, Jake, Duplaix, Mathilde, Durante-Mangoni, Emanuele, Durham, Lucian, III, Dussol, Bertrand, Duthoit, Juliette, Duval, Xavier, Dyrhol-Riise, Anne Margarita, Ean, Sim Choon, Echeverria-Villalobos, Marco, Egan, Siobhan, Eira, Carla, El Sanharawi, Mohammed, Elapavaluru, Subbarao, Elharrar, Brigitte, Ellerbroek, Jacobien, Eloy, Philippine, Elshazly, Tarek, Enderle, Isabelle, Endo, Tomoyuki, Eng, Chan Chee, Engelmann, Ilka, Enouf, Vincent, Epaulard, Olivier, Escher, Martina, Esperatti, Mariano, Esperou, Hélène, Santo, Catarina Espírito, Esposito-Farese, Marina, Estevão, João, Etienne, Manuel, Ettalhaoui, Nadia, Everding, Anna Greti, Evers, Mirjam, Fabre, Isabelle, Fabre, Marc, Faheem, Amna, Fahy, Arabella, Fairfield, Cameron J., Faria, Pedro, Fateena, Hanan, Fatoni, Arie Zainul, Faure, Karine, Favory, Raphaël, Fayed, Mohamed, Feely, Niamh, Feeney, Laura, Fernandes, Jorge, Fernandes, Marília Andreia, Fernandes, Susana, Ferrand, François-Xavier, Devouge, Eglantine Ferrand, Ferrão, Joana, Ferraz, Mário, Ferreira, Sílvia, Ferreira, Bernardo, Ferreira, Benigno, Ferreira, Isabel, Ferriere, Nicolas, Ficko, Céline, Figueiredo-Mello, Claudia, Fiorda, Juan, Flament, Thomas, Flateau, Clara, Fletcher, Tom, Florence, Aline-Marie, Florio, Letizia Lucia, Flynn, Deirdre, Foley, Claire, Foley, Jean, Fonseca, Tatiana, Forsyth, Simon, Foster, Denise, Foti, Giuseppe, Fourn, Erwan, Fowler, Robert A., Fraher, Marianne, Franch-Llasat, Diego, Fraser, John F., Fraser, Christophe, Freire, Marcela Vieira, Ribeiro, Ana Freitas, Fritz, Ricardo, Fry, Stéphanie, Fuentes, Nora, Fukuda, Masahiro, Gaborieau, Valérie, Gaci, Rostane, Gagliardi, Massimo, Gagnard, Jean-Charles, Gagneux-Brunon, Amandine, Gaião, Sérgio, Skeie, Linda Gail, Gallagher, Phil, Gamble, Carrol, Gani, Yasmin, Garan, Arthur, Garcia, Rebekha, Barrio, Noelia García, Garcia-Gallo, Esteban, Garot, Denis, Garrait, Valérie, Gault, Nathalie, Gavin, Aisling, Gavrylov, Anatoliy, Gaymard, Alexandre, Gebauer, Johannes, Geraud, Eva, Morlaes, Louis Gerbaud, Germano, Nuno, Ghosn, Jade, Giani, Marco, Gibson, Jess, Gigante, Tristan, Gilg, Morgane, Gilroy, Elaine, Giordano, Guillermo, Girvan, Michelle, Gissot, Valérie, Glikman, Daniel, Gnall, Eric, Goehringer, François, Goepel, Siri, Goffard, Jean-Christophe, Goh, Jin Yi, Golob, Jonathan, Gómez-Junyent, Joan, Gominet, Marie, Gonzalez, Alicia, Gordon, Patricia, Gorenne, Isabelle, Gormley, Conor, Goubert, Laure, Goujard, Cécile, Goulenok, Tiphaine, Grable, Margarite, Graf, Jeronimo, Grandin, Edward Wilson, Granier, Pascal, Grasselli, Giacomo, Green, Christopher A., Greene, Courtney, Greenhalf, William, Greffe, Segolène, Grieco, Domenico Luca, Griffee, Matthew, Griffiths, Fiona, Grigoras, Ioana, Groenendijk, Albert, Gruner, Heidi, Gu, Yusing, Guedj, Jérémie, Guego, Martin, Guellec, Dewi, Guerreiro, Daniela, Guery, Romain, Guillaumot, Anne, Guilleminault, Laurent, de Castro, Maisa Guimarães, Guimard, Thomas, Haalboom, Marieke, Haber, Daniel, Habraken, Hannah, Hachemi, Ali, Hadri, Nadir, Hakak, Sheeba, Hall, Adam, Hall, Matthew, Halpin, Sophie, Hamer, Ansley, Hamidfar, Rebecca, Hammond, Terese, Hammond, Naomi, Han, Lim Yuen, Haniffa, Rashan, Hao, Kok Wei, Hardwick, Hayley, Harrison, Ewen M., Harrison, Janet, Ekow Harrison, Samuel Bernard, Hartman, Alan, Hashmi, Junaid, Hayes, Ailbhe, Hays, Leanne, Heerman, Jan, Heggelund, Lars, Hendry, Ross, Hennessy, Martina, Henriquez-Trujillo, Aquiles, Hentzien, Maxime, Hernandez, Diana, Hernandez-Montfort, Jaime, Hershey, Andrew, Hesstvedt, Liv, Higgins, Eibhlin, Higgins, Dawn, Higgins, Rupert, Hinchion, Rita, Hinton, Samuel, Hiraiwa, Hiroaki, Hitoto, Hikombo, Ho, Antonia, Ho, Yi Bin, Hoctin, Alexandre, Hoffmann, Isabelle, Hoh, Wei Han, Hoiting, Oscar, Holt, Rebecca, Holter, Jan Cato, Horby, Peter, Horcajada, Juan Pablo, Hoshino, Koji, Houas, Ikram, Hough, Catherine L., Houltham, Stuart, Ming-Yang Hsu, Jimmy, Hulot, Jean-Sébastien, Hurd, Abby, Ijaz, Samreen, Ikram, M. Arfan, Illes, Hajnal-Gabriela, Imbert, Patrick, Inácio, Hugo, Infante Dominguez, Carmen, Ing, Yun Sii, Iosifidis, Elias, Ippolito, Mariachiara, Isgett, Sarah, Isidoro, Tiago, Ismail, Nadiah, Isnard, Margaux, Itai, Junji, Ivulich, Daniel, Jaafar, Danielle, Jaafoura, Salma, Jabot, Julien, Jackson, Clare, Janes, Victoria, Jaquet, Pierre, Jassat, Waasila, Jaud-Fischer, Coline, Jaureguiberry, Stéphane, Jaworsky, Denise, Jego, Florence, Jelani, Anilawati Mat, Jenum, Synne, Jimbo-Sotomayor, Ruth, Joe, Ong Yiaw, Jorge García, Ruth N., Joseph, Cédric, Joseph, Mark, Jourdain, Mercé, Jouvet, Philippe, Jung, Anna, Jung, Hanna, Juzar, Dafsah, Kafif, Ouifiya, Kaguelidou, Florentia, Kaisbain, Neerusha, Kaleesvran, Thavamany, Kali, Sabina, Kalomoiri, Smaragdi, Ayadi Kamaluddin, Muhammad Aisar, Che Kamaruddin, Zul Amali, Kamarudin, Nadiah, Kandamby, Darshana Hewa, Kandel, Chris, Kang, Kong Yeow, Karpayah, Pratap, Kartsonaki, Christiana, Kasugai, Daisuke, Kataria, Anant, Katz, Kevin, Kaur, Aasmine, Kay, Christy, Kayyali, Lamees, Keane, Hannah, Keating, Seán, Kelly, Claire, Kelly, Yvelynne, Kelly, Andrea, Kelly, Niamh, Kelly, Aoife, Kelly, Sadie, Kelsey, Maeve, Kennedy, Ryan, Kennon, Kalynn, Kernan, Maeve, Kerroumi, Younes, Keshav, Sharma, Khalid, Imrana, Khalil, Antoine, Khan, Coralie, Khan, Irfan, Kho, Michelle E., Khoo, Saye, Khoo, Ryan, Khoo, Denisa, Kiat, Khor How, Kida, Yuri, Kiiza, Peter, Granerud, Beathe Kiland, Kildal, Anders Benjamin, Kimmoun, Antoine, Kindgen-Milles, Detlef, King, Alexander, Kitamura, Nobuya, Klenerman, Paul, Klont, Rob, Bekken, Gry Kloumann, Knight, Stephen R., Vasconcelos, Malte Kohns, Komatsu, Mamoru, Kosgei, Caroline, Kpangon, Arsène, Krawczyk, Karolina, Krishnan, Sudhir, Krishnan, Vinothini, Kruglova, Oksana, Kumar, Deepali, Kumar, Ganesh, Vecham, Pavan Kumar, Kuriakose, Dinesh, Kurtzman, Ethan, Kutsogiannis, Demetrios, Kutsyna, Galyna, Kyriakoulis, Konstantinos, Lachatre, Marie, Lacoste, Marie, Laffey, John G., Lafhej, Nadhem, Lagrange, Marie, Laine, Fabrice, Lairez, Olivier, Lalueza, Antonio, Lambert, Marc, Lamontagne, François, Langelot-Richard, Marie, Langlois, Vincent, Lantang, Eka Yudha, Lanza, Marina, Laouénan, Cédric, Laribi, Samira, Lariviere, Delphine, Lasry, Stéphane, Launay, Odile, Laureillard, Didier, Lavie-Badie, Yoan, Law, Andy, Lawrence, Teresa, Lawrence, Cassie, Le, Minh, Le Bihan, Clément, Le Bris, Cyril, Le Falher, Georges, Le Fevre, Lucie, Le Hingrat, Quentin, Le Maréchal, Marion, Mestre, Soizic Le, Le Moal, Gwenaël, Le Moing, Vincent, Le Nagard, Hervé, LeTurnier, Paul, Leal, Ema, Santos, Marta Leal, Lee, Todd C., Lee, Su Hwan, Lee, James, Lee, Jennifer, Lee, Heng Gee, Lee, Biing Horng, Lee, Yi Lin, Leeming, Gary, Lefebvre, Bénédicte, Lefebvre, Laurent, Lefèvre, Benjamin, LeGac, Sylvie, Lelievre, Jean-Daniel, Lellouche, François, Lemaignen, Adrien, Lemee, Véronique, Lemeur, Anthony, Lemmink, Gretchen, Lene, Ha Sha, Lennon, Jenny, León, Rafael, Leone, Marc, Leone, Michela, Lepiller, Quentin, Lescure, François-Xavier, Lesens, Olivier, Lesouhaitier, Mathieu, Lester-Grant, Amy, Letrou, Sophie, Levy, Bruno, Levy, Yves, Levy-Marchal, Claire, Lewandowska, Katarzyna, L'Her, Erwan, Bassi, Gianluigi Li, Liegeon, Geoffrey, Lim, Wei Shen, Lim, Kah Chuan, Lima, Chantre, Lina, Bruno, Lina, Lim, Lind, Andreas, Lingas, Guillaume, Lion-Daolio, Sylvie, Lissauer, Samantha, Liu, Keibun, Livrozet, Marine, Lizotte, Patricia, Lolong, Navy, Loon, Leong Chee, Lopes, Diogo, Lopez-Colon, Dalia, Loschner, Anthony L., Loubet, Paul, Loufti, Bouchra, Louis, Guillame, Lourenco, Silvia, Lee Low, Lee, Lowik, Marije, Loy, Jia Shyi, Lucet, Jean-Christophe, Bermejo, Carlos Lumbreras, Luna, Carlos M., Lungu, Olguta, Luong, Liem, Luque, Nestor, Luton, Dominique, Lwin, Nilar, Lyons, Ruth, Maasikas, Olavi, Mabiala, Oryane, Machado, Moïse, Machado, Sara, Macheda, Gabriel, Madiha, Hashmi, de la Calle, Guillermo Maestro, Mahieu, Rafael, Mahy, Sophie, Maia, Ana Raquel, Maier, Lars S., Maillet, Mylène, Maitre, Thomas, Malfertheiner, Maximilian, Malik, Nadia, Mallon, Paddy, Maltez, Fernando, Malvy, Denis, Manda, Victoria, Mandelbrot, Laurent, Manetta, Frank, Mankikian, Julie, Manning, Edmund, Manuel, Aldric, Sant`Ana Malaque, Ceila Maria, Marino, Flávio, Markowicz, Samuel, Marques, Ana, Marquis, Catherine, Marsh, Brian, Marsh, Laura, Marshal, Megan, Marshall, John, Martelli, Celina Turchi, Martin, Emily, Martin-Blondel, Guillaume, Martinez, F. Eduardo, Martin-Loeches, Ignacio, Martinot, Martin, Martins, João, Martins, Ana, Martins, Nuno, Rego, Caroline Martins, Martucci, Gennaro, Martynenko, Olga, Marwali, Eva Miranda, Marzukie, Marsilla, Maslove, David, Mason, Sabina, Mat Nor, Mohd Basri, Matan, Moshe, Mathieu, Daniel, Mattei, Mathieu, Maulin, Laurence, Maxwell, Michael, Maynar, Javier, Mazzoni, Thierry, Sweeney, Lisa Mc, McArthur, Colin, McCanny, Peter, McCarthy, Anne, McCarthy, Aine, McCloskey, Colin, McConnochie, Rachael, McDermott, Sherry, McDonald, Sarah E., McElroy, Aine, McElwee, Samuel, McEneany, Victoria, McEvoy, Natalie, McGeer, Allison, McKay, Chris, McKeown, Johnny, McLean, Kenneth A., McNally, Paul, McNicholas, Bairbre, McPartlan, Elaine, Meaney, Edel, Mear-Passard, Cécile, Mechlin, Maggie, Mehkri, Omar, Mele, Ferruccio, Melo, Luis, Mendes, Joao Joao, Menon, Kusum, Mentré, France, Mentzer, Alexander J., Mercier, Emmanuelle, Mercier, Noémie, Merckx, Antoine, Mergeay-Fabre, Mayka, Mergler, Blake, Merson, Laura, Mesquita, António, Metwally, Osama, Meybeck, Agnès, Meyer, Dan, Meynert, Alison M., Meysonnier, Vanina, Meziane, Amina, Mezidi, Mehdi, Michelanglei, Céline, Michelet, Isabelle, Mihelis, Efstathia, Mihnovit, Vladislav, Miller, Jennene, Miranda-Maldonado, Hugo, Misnan, Nor Arisah, Mohamed, Tahira Jamal, Eliza Mohamed, Nik Nur, Moin, Asma, Molinos, Elena, Molloy, Brenda, Monahan, Sinead, Mone, Mary, Monteiro, Agostinho, Montes, Claudia, Montrucchio, Giorgia, Moore, Shona C., Moore, Sarah, Cely, Lina Morales, Moro, Lucia, Morton, Ben, Motherway, Catherine, Motos, Ana, Mouquet, Hugo, Perrot, Clara Mouton, Moyet, Julien, Mudara, Caroline, Muh, Ng Yong, Muhamad, Dzawani, Mullaert, Jimmy, Müller, Fredrik, Müller, Karl Erik, Murphy, Aisling, Murphy, Lorna, Murray, Patrick, Murris, Marlène, Murthy, Srinivas, Musaab, Himed, Muyandy, Gugapriyaa, Myrodia, Dimitra Melia, Nagpal, Dave, Nagrebetsky, Alex, Narasimhan, Mangala, Narayanan, Nageswaran, Nazerali-Maitland, Alasdair, Neant, Nadège, Neb, Holger, Neto, Raul, Neumann, Emily, Ng, Pauline Yeung, Ng, Wing Yiu, Nghi, Anthony, Nguyen, Duc, Choileain, Orna Ni, Leathlobhair, Niamh Ni, Nichol, Alistair D., Nitayavardhana, Prompak, Nonas, Stephanie, Mohd Noordin, Nurul Amani, Noret, Marion, Izzati Norharizam, Nurul Faten, Norman, Lisa, Noursadeghi, Mahdad, Nowinski, Adam, Nseir, Saad, Nunez, Jose I., Nyamankolly, Elsa, Brien, Fionnuala O., Callaghan, Annmarie O., O'Callaghan, Annmarie, Occhipinti, Giovanna, OConnor, Derbrenn, O'Donnell, Max, Ogston, Tawnya, Ogura, Takayuki, Oh, Tak-Hyuk, O'Halloran, Sophie, O'Hearn, Katie, Ohshimo, Shinichiro, Oliveira, João, Oliveira, Larissa, Olliaro, Piero L., Ong, David S.Y., Ong, Jee Yan, Oosthuyzen, Wilna, Opavsky, Anne, Openshaw, Peter, Orozco-Chamorro, Claudia Milena, Ortoleva, Jamel, Osatnik, Javier, O'Shea, Linda, O'Sullivan, Miriam, Othman, Siti Zubaidah, Ouamara, Nadia, Ouissa, Rachida, Oziol, Eric, Pagadoy, Maïder, Pages, Justine, Palacios, Amanda, Palmarini, Massimo, Panarello, Giovanna, Panda, Prasan Kumar, Pang, Lai Hui, Panigada, Mauro, Pansu, Nathalie, Papadopoulos, Aurélie, Parke, Rachael, Pasquier, Jérémie, Pastene, Bruno, Patauner, Fabian, Pathmanathan, Mohan Dass, Patrão, Luís, Patricio, Patricia, Patrier, Juliette, Patterson, Lisa, Paul, Christelle, Paul, Mical, Paulos, Jorge, Paxton, William A., Payen, Jean-François, Peake, Sandra L., Peariasamy, Kalaiarasu, Jiménez, Miguel Pedrera, Peek, Giles J., Peelman, Florent, Peiffer-Smadja, Nathan, Peigne, Vincent, Pejkovska, Mare, Pelosi, Paolo, Peltan, Ithan D., Pereira, Rui, Perez, Daniel, Periel, Luis, Perpoint, Thomas, Pesenti, Antonio, Pestre, Vincent, Petrou, Lenka, Petrovic, Michele, Petrov-Sanchez, Ventzislava, Pettersen, Frank Olav, Peytavin, Gilles, Pharand, Scott, Picard, Walter, Picone, Olivier, de Piero, Maria, Pierobon, Carola, Piersma, Djura, Pimentel, Carlos, Pinto, Raquel, Piquard, Valentine, Pires, Catarina, Pironneau, Isabelle, Piroth, Lionel, Piubelli, Chiara, Pius, Riinu, Plantier, Laurent, Png, Hon Shen, Poissy, Julien, Pokeerbux, Ryadh, Poli, Sergio, Pollakis, Georgios, Ponscarme, Diane, Porto, Diego Bastos, Post, Andra-Maris, Postma, Douwe F., Povoa, Pedro, Póvoas, Diana, Powis, Jeff, Prapa, Sofia, Preau, Sébastien, Prebensen, Christian, Preiser, Jean-Charles, Prinssen, Anton, Pritchard, Mark G., Proença, Lucia, Pudota, Sravya, Puéchal, Oriane, Semedi, Bambang Pujo, Purcell, Gregory, Quesada, Luisa, González, Víctor Quirós, Quist-Paulsen, Else, Quraishi, Mohammed, Qutishat, Fadi, Rabaud, Christian, Rafael, Aldo, Rafiq, Marie, Rahman, Rozanah Abd, Haji Ab Rahman, Ahmad Kashfi, Rainieri, Fernando, Rajahram, Giri Shan, Ramakrishnan, Nagarajan, Ramalho, José, Ramli, Ahmad Afiq, Rammaert, Blandine, Ramos, Grazielle Viana, Ranjan, Ritika, Rapp, Christophe, Rasmin, Menaldi, Rätsep, Indrek, Ravi, Tharmini, Real, Andre, Rebaudet, Stanislas, Redl, Sarah, Reeve, Brenda, Reid, Liadain, Reikvam, Dag Henrik, Reis, Renato, Rello, Jordi, Remppis, Jonathan, Remy, Martine, Ren, Hongru, Renk, Hanna, Resseguier, Anne-Sophie, Revest, Matthieu, Rewa, Oleksa, Reyes, Tiago, Reyes, Luis Felipe, Ribeiro, Maria Ines, Richardson, David, Richardson, Denise, Richier, Laurent, Atikah Ahmad Ridzuan, Siti Nurul, Rios, Ana L., Rishu, Asgar, Rispal, Patrick, Risso, Karine, Rizer, Nicholas, Robba, Chiara, Roberto, André, Roberts, Stephanie, Robertson, David L., Robineau, Olivier, Roche-Campo, Ferran, Rodari, Paola, Rodeia, Simão, Roessler, Bernhard, Roger, Pierre-Marie, Roger, Claire, Roilides, Emmanuel, Rojek, Amanda, Romaru, Juliette, Roncon-Albuquerque, Roberto, Jr., Roriz, Mélanie, Rosa-Calatrava, Manuel, Rose, Michael, Rosenberger, Dorothea, Rossanese, Andrea, Rossetti, Matteo, Rossignol, Bénédicte, Rossignol, Patrick, Rousset, Stella, Roy, Carine, Roze, Benoît, Russell, Clark D., Ryan, Maria, Ryan, Maeve, Ryckaert, Steffi, Holten, Aleksander Rygh, Saba, Isabela, Sadat, Musharaf, Sahraei, Valla, Saint-Gilles, Maximilien, Sakiyalak, Pranya, Salazar, Leonardo, Sales, Gabriele, Sallaberry, Stéphane, Gandonniere, Charlotte Salmon, Salvator, Hélène, Sanchez, Olivier, Sanchez, Emely, Sanchez-Miralles, Angel, Sancho-Shimizu, Vanessa, Sandhu, Gyan, Sandhu, Zulfiqar, Sandrine, Pierre-François, Sandulescu, Oana, Santos, Marlene, Sarfo-Mensah, Shirley, Sarmento Banheiro, Bruno, Sarmiento, Iam Claire E., Sarton, Benjamin, Satyapriya, Sree, Satyawati, Rumaisah, Saviciute, Egle, Savvidou, Parthena, Saw, Yen Tsen, Schaffer, Justin, Schermer, Tjard, Scherpereel, Arnaud, Schneider, Marion, Schroll, Stephan, Schwameis, Michael, Scicluna, Brendan, Scott, Janet T., Scott-Brown, James, Sedillot, Nicholas, Seitz, Tamara, Selvarajoo, Mageswari, Semaille, Caroline, Semple, Malcolm G., Senian, Rasidah Bt, Senneville, Eric, Sepulveda, Claudia, Sequeira, Filipa, Sequeira, Tânia, Neto, Ary Serpa, Balazote, Pablo Serrano, Shadowitz, Ellen, Shahidan, Syamin Asyraf, Shamsah, Mohammad, Sharjeel, Shaikh, Sharma, Pratima, Shaw, Catherine A., Shaw, Victoria, Sheenan, John Robert, Shi, Haixia, Shime, Nobuaki, Shimizu, Keiki, Shrapnel, Sally, Shum, Hoi Ping, Mohammed, Nassima Si, Siang, Ng Yong, Sibiude, Jeanne, Siddiqui, Atif, Sigfrid, Louise, Sillaots, Piret, Silva, Catarina, Silva, Rogério, Silva, Maria Joao, Lim Heng, Benedict Sim, Sin, Wai Ching, Singh, Punam, Singh, Budha Charan, Sitompul, Pompini Agustina, Sivam, Karisha, Skogen, Vegard, Smith, Sue, Smood, Benjamin, Smyth, Coilin, Smyth, Michelle, Snacken, Morgane, So, Dominic, Soh, Tze Vee, Solomon, Joshua, Solomon, Tom, Somers, Emily, Sommet, Agnès, Song, Rima, Song, Myung Jin, Song, Tae, Chia, Jack Song, Sonntagbauer, Michael, Soom, Azlan Mat, Sotto, Albert, Soum, Edouard, Sousa, Marta, Sousa, Ana Chora, Uva, Maria Sousa, Souza-Dantas, Vicente, Sperry, Alexandra, Spinuzza, Elisabetta, Sriskandan, Shiranee, Stabler, Sarah, Staudinger, Thomas, Stecher, Stephanie-Susanne, Steinsvik, Trude, Stienstra, Ymkje, Stiksrud, Birgitte, Stolz, Eva, Stone, Amy, Streinu-Cercel, Adrian, Streinu-Cercel, Anca, Stuart, Ami, Stuart, David, Su, Richa, Suen, Jacky Y., Suen, Gabriel, Sukumar, Prasanth, Sultana, Asfia, Summers, Charlotte, Supic, Dubravka, Suppiah, Deepashankari, Surovcová, Magdalena, Syahrin, Sarah, Syrigos, Konstantinos, Sztajnbok, Jaques, Szuldrzynski, Konstanty, Tabrizi, Shirin, Taccone, Fabio S., Tagherset, Lysa, Taib, Shahdattul Mawarni, Taleb, Sara, Talsma, Jelmer, Tampubolon, Maria Lawrensia, Tan, Kim Keat, Tan, Yan Chyi, Tanaka, Hiroyuki, Tanaka, Taku, Taniguchi, Hayato, Tardivon, Coralie, Tattevin, Pierre, Taufik, M. Azhari, Tawfik, Hassan, Tedder, Richard S., Tee, Tze Yuan, Teixeira, João, Tejada, Sofia, Tellier, Marie-Capucine, Teoh, Sze Kye, Teotonio, Vanessa, Téoulé, François, Terpstra, Pleun, Terrier, Olivier, Terzi, Nicolas, Tessier-Grenier, Hubert, Tey, Adrian, Mohd Thabit, Alif Adlan, Tham, Zhang Duan, Thangavelu, Suvintheran, Theron, Elmi, Thibault, Vincent, Thiberville, Simon-Djamel, Thill, Benoît, Thirumanickam, Jananee, Thompson, Shaun, Thomson, David, Thomson, Emma C., Thorpe, Mathew, Thanga Thurai, Surain Raaj, Thwaites, Ryan S., Tierney, Paul, Tieroshyn, Vadim, Timsit, Jean-François, Tissot, Noémie, Toal, Fiona, Yang Toh, Jordan Zhien, Toki, Maria, Tonby, Kristian, Tonnii, Sia Loong, Torre, Marta, Torres, Margarida, Torres, Antoni, Torres-Zevallos, Hernando, Towers, Michael, Trapani, Tony, Trioux, Théo, Tromeur, Cécile, Trontzas, Ioannis, Trouillon, Tiffany, Truong, Jeanne, Tual, Christelle, Tubiana, Sarah, Tuite, Helen, Turgeon, Alexis F., Turmel, Jean-Marie, Turtle, Lance C.W., Tveita, Anders, Twardowski, Pawel, Uchiyama, Makoto, Udy, Andrew, Ullrich, Roman, Uribe, Alberto, Usman, Asad, Uyeki, Timothy M., Vajdovics, Cristinava, Val-Flores, Luís, Valran, Amélie, Van de Velde, Stijn, van den Berge, Marcel, Van der Feltz, Machteld, van der Palen, Job, van der Valk, Paul, Van Der Vekens, Nicky, Van der Voort, Peter, Van Der Werf, Sylvie, van Gulik, Laura, Van Hattem, Jarne, van Netten, Carolien, van Someren Gréve, Frank, van Veen, Ilonka, Van Willigen, Hugo, Vanel, Noémie, Vanoverschelde, Henk, Varghese, Pooja, Varrone, Michael, Vasudayan, Shoban Raj, Vauchy, Charline, Veeran, Shaminee, Veislinger, Aurélie, Vencken, Sebastian, Ventura, Sara, Verbon, Annelies, Vidal, José Ernesto, Vieira, César, Villanueva, Joy Ann, Villar, Judit, Villeneuve, Pierre-Marc, Villoldo, Andrea, Visseaux, Benoit, Visser, Hannah, Vitiello, Chiara, Vonkeman, Harald, Vuotto, Fanny, Wahab, Noor Hidayu, Wahab, Suhaila Abdul, Wahid, Nadirah Abdul, Wainstein, Marina, Walsh, Laura, Wang, Chih-Hsien, Webb, Steve, Wei, Jia, Weil, Katharina, Wen, Tan Pei, Wesselius, Sanne, Wham, Murray, Whelan, Bryan, White, Nicole, Wicky, Paul Henri, Wiedemann, Aurélie, Wijaya, Surya Otto, Wille, Keith, Willems, Sue, Williams, Bailey, Williams, Virginie, Williams, Patricia J., Wils, Evert-Jan, Wittman, Jessica, Wong, Calvin, Wong, Xin Ci, Wong, Yew Sing, Wong, Teck Fung, Xian, Gan Ee, Xian, Lim Saio, Kuan, Pei Xuan, Xynogalas, Ioannis, Binti Mohd Yakop, Siti Rohani, Yamazaki, Masaki, Yarad, Elizabeth, Yazdanpanah, Yazdan, Liang Hing, Nicholas Yee, Yelnik, Cécile, Yeoh, Chian Hui, Yerkovich, Stephanie, Yokoyama, Toshiki, Yonis, Hodane, Yousif, Obada, Zaaqoq, Akram, Zabbe, Marion, Zacharowski, Kai, Zahid, Masliza, Zahran, Maram, Binti Zaidan, Nor Zaila, Zambon, Maria, Zambrano, Miguel, Zanella, Alberto, Zaynah, Nurul, Zayyad, Hiba, Zoufaly, Alexander, Zucman, David, Griffee, Matthew J., Bozza, Patricia T., Eddington, Devin P., Fanning, Jonathon P., Alexander, Peta M.A., and Fraser, John
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- 2023
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7. Making EHRs Trustable: A Quality Analysis of EHR-Derived Datasets for COVID-19 Research
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Pedrera-Jimenez, Miguel, primary, Garcia-Barrio, Noelia, additional, Rubio-Mayo, Paula, additional, Maestro, Guillermo, additional, Lalueza, Antonio, additional, Garcia-Reyne, Ana, additional, Zamorro, María José, additional, Pons, Alejandra, additional, Sanchez-Martin, María Jesús, additional, Cruz-Rojo, Jaime, additional, Quiros, Víctor, additional, Aguado, José María, additional, Cruz-Bermudez, Juan Luis, additional, Bernal, José Luis, additional, Merson, Laura, additional, Lumbreras, Carlos, additional, and Serrano, Pablo, additional
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- 2022
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8. Building an i2b2-Based Population Repository for COVID-19 Research
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Pedrera-Jimenez, Miguel, primary, Garcia-Barrio, Noelia, additional, Hernandez-Ibarburu, Gema, additional, Baselga, Blanca, additional, Blanco, Alvar, additional, Calvo-Boyero, Fernando, additional, Gutierrez-Sacristan, Alba, additional, Quiros, Víctor, additional, Cruz-Bermudez, Juan Luis, additional, Bernal, José Luis, additional, Meloni, Laura, additional, Perez-Rey, David, additional, Palchuk, Matvey, additional, Kohane, Isaac, additional, and Serrano, Pablo, additional
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- 2022
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9. KRAS p.G12C mutation occurs in 1% of EGFR-mutated advanced non-small-cell lung cancer patients progressing on a first-line treatment with a tyrosine kinase inhibitor
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Serna-Blasco, R., Sánchez-Herrero, E., Sanz-Moreno, S., Rodriguez-Festa, A., García-Veros, E., Casarrubios, M., Sierra-Rodero, B., Laza-Briviesca, R., Cruz-Bermúdez, A., Mielgo-Rubio, X., Sánchez-Hernández, A., Uribelarrea, E.A., Calvo, V., Romero, A., and Provencio, M.
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- 2021
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10. Obtaining EHR-derived datasets for COVID-19 research within a short time: a flexible methodology based on Detailed Clinical Models
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Pedrera-Jiménez, Miguel, García-Barrio, Noelia, Cruz-Rojo, Jaime, Terriza-Torres, Ana Isabel, López-Jiménez, Elena Ana, Calvo-Boyero, Fernando, Jiménez-Cerezo, María Jesús, Blanco-Martínez, Alvar Javier, Roig-Domínguez, Gustavo, Cruz-Bermúdez, Juan Luis, Bernal-Sobrino, José Luis, Serrano-Balazote, Pablo, and Muñoz-Carrero, Adolfo
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- 2021
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11. Neoadjuvant chemotherapy and nivolumab in resectable non-small-cell lung cancer (NADIM): an open-label, multicentre, single-arm, phase 2 trial
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Provencio, Mariano, Nadal, Ernest, Insa, Amelia, García-Campelo, María Rosario, Casal-Rubio, Joaquín, Dómine, Manuel, Majem, Margarita, Rodríguez-Abreu, Delvys, Martínez-Martí, Alex, De Castro Carpeño, Javier, Cobo, Manuel, López Vivanco, Guillermo, Del Barco, Edel, Bernabé Caro, Reyes, Viñolas, Nuria, Barneto Aranda, Isidoro, Viteri, Santiago, Pereira, Eva, Royuela, Ana, Casarrubios, Marta, Salas Antón, Clara, Parra, Edwin R, Wistuba, Ignacio, Calvo, Virginia, Laza-Briviesca, Raquel, Romero, Atocha, Massuti, Bartomeu, and Cruz-Bermúdez, Alberto
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- 2020
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12. Reconstructing the patient’s natural history from electronic health records
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Najafabadipour, Marjan, Zanin, Massimiliano, Rodríguez-González, Alejandro, Torrente, Maria, Nuñez García, Beatriz, Cruz Bermudez, Juan Luis, Provencio, Mariano, and Menasalvas, Ernestina
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- 2020
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13. Validation of extracorporeal membrane oxygenation mortality prediction and severity of illness scores in an international COVID-19 cohort
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Shah, N, Xue, B, Xu, Z, Yang, H, Marwali, E, Dalton, H, Payne, P, Lu, C, Said, A, Abdukahil, S, Abdulkadir, N, Absil, L, Acker, A, Adriao, D, Hssain, A, Akwani, C, Qasim, E, Alalqam, R, Al-Dabbous, T, Alex, B, Al-Fares, A, Alfoudri, H, Aliudin, J, Alves, J, Alves, R, Cabrita, J, Amaral, M, Amira, N, Andini, R, Anthonidass, S, Antonelli, M, Arabi, Y, Arcadipane, A, Arenz, L, Arnold-Day, C, Arora, L, Arora, R, Ashraf, M, Asyraf, A, Atique, A, Bach, B, Baillie, J, Bak, E, Bakar, N, Balakrishnan, M, Barbalho, R, Barclay, W, Barnett, S, Barnikel, M, Barrasa, H, Barrigoto, C, Baruch, J, Hassin Basri, M, Battaglini, D, Bautista Rincon, D, Bee, K, Begum, H, Beljantsev, A, Benjiman, L, Bento, L, Bernal Sobrino, J, Bertolino, L, Bhatt, A, Bianco, C, Bidin, F, Humaid, F, Bin Kamarudin, M, Blanco-Schweizer, P, Bloos, F, Boccia, F, Bogaert, D, Borges, D, Bouhmani, D, Bouziotis, J, Boylan, M, Bozza, F, Brazzi, L, Brewster, D, Brickell, K, Broadley, T, Brozzi, N, Buchtele, N, Burrell, A, Cabral, S, Garces, R, Calligy, K, Campbell, P, Cardoso, S, Cardoso, F, Carelli, S, Carrier, F, Carson, G, Cascao, M, Casimiro, J, Castanheira, N, Castro, I, Catarino, A, Cavalin, R, Cavalli, G, Cavayas, A, Chand, M, Chen, A, Chen, Y, Cheng, M, Chica, J, Chidambaram, S, Tho, L, Cho, S, Chow, T, Chua, H, Chua, J, Cidade, J, Citarella, B, Ciullo, A, Clarke, J, Clohisey, S, Codan, C, Coles, J, Colombo, S, Connor, M, Cooke, G, Corley, A, Cornelis, S, Corpuz, A, Crump, J, Cruz, C, Cruz Bermudez, J, Rojo, J, Csete, M, Cullen, A, Cummings, M, Curley, G, Custodio, P, Filipe, A, Dabaliz, A, Dagens, A, Dahly, D, Dalton, J, Damas, J, Dankwa, E, Dantas, J, de Loughry, G, de Rosa, R, de Silva, T, Deacon, J, Dean, D, Debenedictis, B, Dell'Amore, A, Denis, E, Depuydt, P, Desai, M, Dhangar, P, Diaz, R, Dieperink, W, Docherty, A, Doherty, H, Donnelly, C, Donohue, C, Downer, T, Drake, T, Duculan, T, Dunning, J, Duplaix, M, Durante-Mangoni, E, Durham, L, Ean, S, Echeverria-Villalobos, M, Elotmani, L, Elshazly, T, Eng, C, Escher, M, Santo, C, Estevao, J, Everding, A, Fairfield, C, Faria, P, Fateena, H, Fayed, M, Fernandes, J, Fernandes, M, Fernandes, S, Ferrao, J, Ferraz, M, Ferreira, B, Figueiredo-Mello, C, Fiorda, J, Fletcher, T, Florio, L, Fonseca, T, Forsyth, S, Foti, G, Fowler, R, Fraser, J, Fraser, C, Ribeiro, A, French, C, Fukuda, M, G, A, Gagliardi, M, Gaiao, S, Gamble, C, Gani, Y, Garcia, R, Barrio, N, Gavin, A, Germano, N, Giani, M, Gilroy, E, Girvan, M, Gnall, E, Goffard, J, Goh, J, Golob, J, Gonzalez, A, Graf, J, Grasselli, G, Green, C, Greenhalf, W, Grieco, D, Griffee, M, Griffiths, F, Lordemann, A, Gruner, H, Gu, Y, Guerreiro, D, Castro, M, Hakak, S, Hall, M, Halpin, S, Hamer, A, Hammond, T, Hammond, N, Han, L, Hao, K, Hardwick, H, Ekow Harrison, S, Harrison, E, Harrison, J, Heerman, J, Hendry, R, Hennessy, M, Higgins, D, Higgins, R, Hinton, S, Ho, Y, Ho, A, Hoh, W, Holt, R, Horby, P, Hsu, J, Hurd, A, Ijaz, S, Inacio, H, Ing, Y, Isgett, S, Isidoro, T, Ismail, N, Ivulich, D, Jackson, C, Jelani, A, Joe, O, Joshi, S, Jung, A, Kaisbain, N, Kaleesvran, T, Ayadi Kamaluddin, M, Che Kamaruddin, Z, Kamarudin, N, Kang, K, Karpayah, P, Kartsonaki, C, Kay, C, Keating, S, Kelly, A, Kelly, S, Kennon, K, Khalid, I, Khan, I, Kho, M, Khoo, R, Khoo, D, Khoo, S, Kiat, K, Kida, Y, Kim, J, Kitamura, N, Klenerman, P, Knight, S, Kobbe, R, Krishnan, V, Kumar, D, Kumar, G, Kurtzman, E, Lalueza, A, Lanza, M, Law, A, Lee, T, Lee, H, Lee, B, Lee, Y, Lee, J, Leeming, G, Lene, H, Leone, M, Bassi, G, Lim, K, Lim, W, Lina, L, Liu, K, Loforte, A, Loon, L, Lopes, D, Low, L, Loy, J, Bermejo, C, Lunn, M, Lyons, R, Maasikas, O, Machado, S, de la Calle, G, Maier, L, Malfertheiner, M, Malik, N, Sant'ana Malaque, C, Marino, D, Marques, A, Marsh, B, Marsh, L, Marshall, J, Martin, E, Martinez, F, Martin-Loeches, I, Martins, J, Martins, A, Rego, C, Martucci, G, Marzukie, M, Maynar, J, Mcarthur, C, Mccanny, P, Mccloskey, C, Mcdermott, S, Mcdonald, S, Mcelroy, A, Mcelwee, S, Mcevoy, N, Mckay, C, Mckeown, J, Mclean, K, Mele, F, Menkiti, O, Mentzer, A, Mergler, B, Merson, L, Mesquita, A, Meynert, A, Mihnovit, V, Miller, J, Misnan, N, Mohamed, T, Eliza Mohamed, N, Moin, A, Mone, M, Monteiro, A, Montes, C, Montrucchio, G, Moore, S, Motos, A, Muh, N, Muhamad, D, Murphy, A, Murthy, S, Muyandy, G, Nagpal, D, Nagrebetsky, A, Neto, R, Neumann, E, Ng, W, Choileain, O, Nichol, A, Nitayavardhana, P, Nonas, S, Mohd Noordin, N, Izzati Norharizam, N, Norman, L, Noursadeghi, M, Occhipinti, G, O'Donnell, M, Ogura, T, Oliveira, J, Olliaro, P, Ong, J, Oosthuyzen, W, Openshaw, P, Ortoleva, J, Osatnik, J, Othman, S, Palmarini, M, Panarello, G, Panda, P, Pang, L, Panigada, M, Parke, R, Patauner, F, Pathmanathan, M, Patterson, L, Paulos, J, Paxton, W, Peake, S, Peariasamy, K, Jimenez, M, Pelosi, P, Pereira, R, Periel, L, Pesenti, A, Pimentel, C, Pires, C, Pius, R, Png, H, Poli, S, Pollakis, G, Post, A, Postma, D, Povoa, P, Povoas, D, Preiser, J, Pritchard, M, Proenca, L, Semedi, B, Quesada, L, Quinones-Cardona, V, Gonzalez, V, Quraishi, M, Rafael, A, Rahman, R, Rahman, A, Rajahram, G, Ramalho, J, Ramli, A, Ramos, G, Rangappa, R, Ratsep, I, Rau, C, Ravi, T, Reis, R, Rello, J, Ren, H, Richardson, D, Ahmad Ridzuan, S, Rios, A, Robba, C, Roberto, A, Roberts, S, Robertson, D, Rodeia, S, Roessler, B, Roger, C, Rojek, A, Roncon-Albuquerque, R, Rose, M, Rosenberger, D, Rossetti, M, Russell, C, Ryckaert, S, Saba, I, Sadat, M, Sakiyalak, P, Salazar, L, Sales, G, Sanchez, E, Sancho-Shimizu, V, Sandhu, G, Santos, M, Satyapriya, S, Saviciute, E, Saw, Y, Schaffer, J, Schermer, T, Schwameis, M, Scott, J, Scott-Brown, J, Selvarajoo, M, Semple, M, Senian, R, Sequeira, F, Sequeira, T, Neto, A, Balazote, P, Shahidan, S, Shamsah, M, Sharma, P, Shaw, C, Shaw, V, Shetty, R, Shi, H, Shimizu, H, Shimizu, K, Shrapnel, S, Shum, H, Siang, N, Sigfrid, L, Sillaots, P, Silva, C, Heng, B, Singh, P, Singh, M, Sivam, K, Smith, S, Smood, B, Smyth, C, Snacken, M, Soh, T, Solomon, J, Solomon, T, Somers, E, 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P. R., Lu C., Said A. S., Abdukahil S. A., Abdulkadir N. N., Absil L., Acker A., Adriao D., Hssain A. A., Akwani C., Qasim E. A., Alalqam R., Al-Dabbous T., Alex B., Al-Fares A., Alfoudri H., Aliudin J., Alves J., Alves R., Alves J. M., Cabrita J. A., Amaral M., Amira N., Andini R., Anthonidass S., Antonelli M., Arabi Y., Arcadipane A., Arenz L., Arnold-Day C., Arora L., Arora R., Ashraf M., Asyraf A., Atique A., Bach B., Baillie J. K., Bak E., Bakar N. A., Balakrishnan M., Barbalho R., Barclay W. S., Barnett S. U., Barnikel M., Barrasa H., Barrigoto C., Baruch J., Hassin Basri M. F., Battaglini D., Bautista Rincon D. F., Bee K. H., Begum H., Beljantsev A., Benjiman L. E., Bento L., Bernal Sobrino J. L., Bertolino L., Bhatt A., Bianco C., Bidin F. N., Humaid F. B., Bin Kamarudin M. N., Blanco-Schweizer P., Bloos F., Boccia F., Bogaert D., Borges D., Bouhmani D., Bouziotis J., Boylan M., Bozza F. A., Brazzi L., Brewster D., Brickell K., Broadley T., Brozzi N., Buchtele N., Burrell A., Cabral S., Cabrita J., Garces R. C., Calligy K., Campbell P., Cardoso S., Cardoso F., Carelli S., Carrier F. M., Carson G., Cascao M., Casimiro J., Castanheira N., Castro I., Catarino A., Cavalin R., Cavalli G. G., Cavayas A., Chand M., Chen A., Chen Y. -S., Cheng M. P., Chica J., Chidambaram S. K., Tho L. C., Cho S. -M., Chow T. S., Chua H. J., Chua J., Cidade J. P., Citarella B. W., Ciullo A., Clarke J., Clohisey S., Codan C., Coles J., Colombo S. M., Connor M., Cooke G. S., Corley A., Cornelis S., Corpuz A. J., Crump J., Cruz C., Cruz Bermudez J. L., Rojo J. C., Csete M., Cullen A., Cummings M., Curley G., Custodio P., Filipe A. S., Dabaliz A. -A., Dagens A., Dahly D., Dalton J., Damas J., Dankwa E. A., Dantas J., de Loughry G., de Rosa R., de Silva T., Deacon J., Dean D., Debenedictis B., Dell'Amore A., Denis E., Depuydt P., Desai M., Dhangar P., Diaz R., Dieperink W., Docherty A. B., Doherty H., Donnelly C. A., Donohue C., Downer T., Drake T., Duculan T., Dunning J., Duplaix M., Durante-Mangoni E., Durham L., Ean S. C., Echeverria-Villalobos M., Elotmani L., Elshazly T., Eng C. C., Escher M., Santo C. E., Estevao J., Everding A. G., Fairfield C. J., Faria P., Fateena H., Fayed M., Fernandes J., Fernandes M. A., Fernandes S., Ferrao J., Ferraz M., Ferreira B., Figueiredo-Mello C., Fiorda J., Fletcher T., Florio L. L., Fonseca T., Forsyth S., Foti G., Fowler R. A., Fraser J. F., Fraser C., Ribeiro A. F., French C., Fukuda M., G A., Gagliardi M., Gaiao S., Gamble C., Gani Y., Garcia R., Barrio N. G., Gavin A., Germano N., Giani M., Gilroy E., Girvan M., Gnall E., Goffard J. -C., Goh J. Y., Golob J., Gonzalez A., Graf J., Grasselli G., Green C. A., Greenhalf W., Grieco D. L., Griffee M., Griffiths F., Lordemann A. G., Gruner H., Gu Y., Guerreiro D., Castro M. G., Hakak S., Hall M., Halpin S., Hamer A., Hammond T., Hammond N., Han L. Y., Hao K. W., Hardwick H., Ekow Harrison S. B., Harrison E. M., Harrison J., Heerman J., Hendry R., Hennessy M., Higgins D., Higgins R., Hinton S., Ho Y. B., Ho A., Hoh W. H., Holt R., Horby P., Hsu J. M. -Y., Hurd A., Ijaz S., Inacio H., Ing Y. S., Isgett S., Isidoro T., Ismail N., Ivulich D., Jackson C., Jelani A. M., Joe O. Y., Joshi S., Jung A., Kaisbain N., Kaleesvran T., Ayadi Kamaluddin M. A., Che Kamaruddin Z. A., Kamarudin N., Kang K. Y., Karpayah P., Kartsonaki C., Kay C., Keating S., Kelly A., Kelly S., Kennon K., Khalid I., Khan I., Kho M. E., Khoo R., Khoo D., Khoo S., Kiat K. H., Kida Y., Kim J. B., Kitamura N., Klenerman P., Knight S. R., Kobbe R., Krishnan V., Kumar D., Kumar G., Kurtzman E., Lalueza A., Lanza M., Law A., Lee T. C., Lee H. G., Lee B. H., Lee Y. L., Lee J., Leeming G., Lene H. S., Leone M., Bassi G. L., Lim K. C., Lim W. S., Lina L., Liu K., Loforte A., Loon L. C., Lopes D., Low L. L., Loy J. S., Bermejo C. L., Lunn M., Lyons R., Maasikas O., Machado S., de la Calle G. M., Maier L. S., Malfertheiner M., Malik N., Sant'ana Malaque C. M., Marino D., Marques A., Marsh B., Marsh L., Marshall J., Martin E., Martinez F. E., Martin-Loeches I., Martins J., Martins A., Rego C. M., Martucci G., Marzukie M., Maynar J., McArthur C., McCanny P., McCloskey C., McDermott S., McDonald S. E., McElroy A., McElwee S., McEvoy N., McKay C., McKeown J., McLean K. A., Mele F., Menkiti O., Mentzer A. J., Mergler B., Merson L., Mesquita A., Meynert A. M., Mihnovit V., Miller J., Misnan N. A., Mohamed T. J., Eliza Mohamed N. N., Moin A., Mone M., Monteiro A., Montes C., Montrucchio G., Moore S. C., Moore S., Motos A., Muh N. Y., Muhamad D., Murphy A., Murthy S., Muyandy G., Nagpal D., Nagrebetsky A., Neto R., Neumann E., Ng W. Y., Choileain O. N., Nichol A. D., Nitayavardhana P., Nonas S., Mohd Noordin N. A., Izzati Norharizam N. F., Norman L., Noursadeghi M., Occhipinti G., O'Donnell M., Ogura T., Oliveira J., Olliaro P. L., Ong J. Y., Oosthuyzen W., Openshaw P., Ortoleva J., Osatnik J., Othman S. Z., Palmarini M., Panarello G., Panda P. K., Pang L. H., Panigada M., Parke R., Patauner F., Pathmanathan M. D., Patterson L., Paulos J., Paxton W. A., Peake S. L., Peariasamy K., Jimenez M. P., Pelosi P., Pereira R., Periel L., Pesenti A., Pimentel C., Pires C., Pius R., Png H. S., Poli S., Pollakis G., Post A. -M., Postma D. F., Povoa P., Povoas D., Preiser J. -C., Pritchard M. G., Proenca L., Semedi B. P., Quesada L., Quinones-Cardona V., Gonzalez V. Q., Quraishi M., Rafael A., Rahman R. A., Rahman A. K. H. A., Rajahram G. S., Ramalho J., Ramli A. A., Ramos G. V., Rangappa R., Ratsep I., Rau C., Ravi T., Reis R., Rello J., Ren H., Richardson D., Ahmad Ridzuan S. N. A., Rios A. L., Robba C., Roberto A., Roberts S., Robertson D. L., Rodeia S., Roessler B., Roger C., Rojek A., Roncon-Albuquerque R., Rose M., Rosenberger D., Rossetti M., Russell C. D., Ryckaert S., Saba I., Sadat M., Sakiyalak P., Salazar L., Sales G., Sanchez E., Sancho-Shimizu V., Sandhu G., Santos M., Satyapriya S., Saviciute E., Saw Y. T., Schaffer J., Schermer T., Schwameis M., Scott J. T., Scott-Brown J., Selvarajoo M., Semple M. G., Senian R. B., Sequeira F., Sequeira T., Neto A. S., Balazote P. S., Shahidan S. A., Shamsah M., Sharma P., Shaw C. A., Shaw V., Shetty R. M., Shi H., Shimizu H., Shimizu K., Shrapnel S., Shum H. P., Siang N. Y., Sigfrid L., Sillaots P., Silva C., Heng B. S. L., Singh P., Singh M., Sivam K., Smith S., Smood B., Smyth C., Snacken M., Soh T. V., Solomon J., Solomon T., Somers E., Song M. J., Sousa M., Uva M. S., Sperry A., Sriskandan S., Staudinger T., Stecher S. -S., Stienstra Y., Stolz E., Stuart A., Stuart D., Suen J. Y., Summers C., Suppiah D., Syahrin S., Sztajnbok J., Szuldrzynski K., Tabrizi S., Taccone F. S., Taib S. M., Taleb S., Talsma J., Tan K. K., Tan Y. C., Tedder R. S., Tee T. Y., Teixeira J., Tejada S., Teoh S. K., Terpstra P., Tessier-Grenier H., Thabit A. A. M., Tham Z. D., Thangavelu S., Thirumanickam J., Thompson S., Thomson D., Thomson E. C., Thorpe M., Thurai S. R. T., Thwaites R. S., Toh J. Z. Y., Tonnii S. L., Torre M., Torres A., Towers M., Trapani T., Turtle L. C. W., Udy A., Ullrich R., Uribe A., Usman A., Uyeki T. M., Val-Flores L., Van de Velde S., Van Der Vekens N., Van der Voort P., Vanoverschelde H., Vasudayan S. R., Veeran S., Ventura S., Vidal J. E., Vieira C., Villanueva J. A., Vitiello C., Wahab N. H., Wahab S. A., Wahid N. A., Wang C. -H., Webb S., Wei J., Wen T. P., Wham M., White N., Wille K., Williams B., Williams V., Williams P. J., Wong C., Wong X. C., Wong Y. S., Wong T. F., Xian G. E., Xian L. S., Xuan K. P., Mohd Yakop S. R. B., Yamazaki M., Yarad E., Hing N. Y. L., Yeoh C. H., Yerkovich S., Yokoyama T., Zaaqoq A., Zahid M., Binti Zaidan N. Z., Zambon M., Zanella A., Zaynah N., Shah, N, Xue, B, Xu, Z, Yang, H, Marwali, E, Dalton, H, Payne, P, Lu, C, Said, A, Abdukahil, S, Abdulkadir, N, Absil, L, Acker, A, Adriao, D, Hssain, A, Akwani, C, Qasim, E, Alalqam, R, Al-Dabbous, T, Alex, B, Al-Fares, A, Alfoudri, H, Aliudin, J, Alves, J, Alves, R, Cabrita, J, Amaral, M, Amira, N, Andini, R, Anthonidass, S, Antonelli, M, Arabi, Y, Arcadipane, A, Arenz, L, Arnold-Day, C, Arora, L, Arora, R, Ashraf, M, Asyraf, A, Atique, A, Bach, B, Baillie, J, Bak, E, Bakar, N, Balakrishnan, M, Barbalho, R, Barclay, W, Barnett, S, Barnikel, M, Barrasa, H, Barrigoto, C, Baruch, J, Hassin Basri, M, Battaglini, D, Bautista Rincon, D, Bee, K, Begum, H, Beljantsev, A, Benjiman, L, Bento, L, Bernal Sobrino, J, Bertolino, L, Bhatt, A, Bianco, C, Bidin, F, Humaid, F, Bin Kamarudin, M, Blanco-Schweizer, P, Bloos, F, Boccia, F, Bogaert, D, Borges, D, Bouhmani, D, Bouziotis, J, Boylan, M, Bozza, F, Brazzi, L, Brewster, D, Brickell, K, Broadley, T, Brozzi, N, Buchtele, N, Burrell, A, Cabral, S, Garces, R, Calligy, K, Campbell, P, Cardoso, S, Cardoso, F, Carelli, S, Carrier, F, Carson, G, Cascao, M, Casimiro, J, Castanheira, N, Castro, I, Catarino, A, Cavalin, R, Cavalli, G, Cavayas, A, Chand, M, Chen, A, Chen, Y, Cheng, M, Chica, J, Chidambaram, S, Tho, L, Cho, S, Chow, T, Chua, H, Chua, J, Cidade, J, Citarella, B, Ciullo, A, Clarke, J, Clohisey, S, Codan, C, Coles, J, Colombo, S, Connor, M, Cooke, G, Corley, A, Cornelis, S, Corpuz, A, Crump, J, Cruz, C, Cruz Bermudez, J, Rojo, J, Csete, M, Cullen, A, Cummings, M, Curley, G, Custodio, P, Filipe, A, Dabaliz, A, Dagens, A, Dahly, D, Dalton, J, Damas, J, Dankwa, E, Dantas, J, de Loughry, G, de Rosa, R, de Silva, T, Deacon, J, Dean, D, Debenedictis, B, Dell'Amore, A, Denis, E, Depuydt, P, Desai, M, Dhangar, P, Diaz, R, Dieperink, W, Docherty, A, Doherty, H, Donnelly, C, Donohue, C, Downer, T, Drake, T, Duculan, T, Dunning, J, Duplaix, M, Durante-Mangoni, E, Durham, L, Ean, S, Echeverria-Villalobos, M, Elotmani, L, Elshazly, T, Eng, C, Escher, M, Santo, C, Estevao, J, Everding, A, Fairfield, C, Faria, P, Fateena, H, Fayed, M, Fernandes, J, Fernandes, M, Fernandes, S, Ferrao, J, Ferraz, M, Ferreira, B, Figueiredo-Mello, C, Fiorda, J, Fletcher, T, Florio, L, Fonseca, T, Forsyth, S, Foti, G, Fowler, R, Fraser, J, Fraser, C, Ribeiro, A, French, C, Fukuda, M, G, A, Gagliardi, M, Gaiao, S, Gamble, C, Gani, Y, Garcia, R, Barrio, N, Gavin, A, Germano, N, Giani, M, Gilroy, E, Girvan, M, Gnall, E, Goffard, J, Goh, J, Golob, J, Gonzalez, A, Graf, J, Grasselli, G, Green, C, Greenhalf, W, Grieco, D, Griffee, M, Griffiths, F, Lordemann, A, Gruner, H, Gu, Y, Guerreiro, D, Castro, M, Hakak, S, Hall, M, Halpin, S, Hamer, A, Hammond, T, Hammond, N, Han, L, Hao, K, Hardwick, H, Ekow Harrison, S, Harrison, E, Harrison, J, Heerman, J, Hendry, R, Hennessy, M, Higgins, D, Higgins, R, Hinton, S, Ho, Y, Ho, A, Hoh, W, Holt, R, Horby, P, Hsu, J, Hurd, A, Ijaz, S, Inacio, H, Ing, Y, Isgett, S, Isidoro, T, Ismail, N, Ivulich, D, Jackson, C, Jelani, A, Joe, O, Joshi, S, Jung, A, Kaisbain, N, Kaleesvran, T, Ayadi Kamaluddin, M, Che Kamaruddin, Z, Kamarudin, N, Kang, K, Karpayah, P, Kartsonaki, C, Kay, C, Keating, S, Kelly, A, Kelly, S, Kennon, K, Khalid, I, Khan, I, Kho, M, Khoo, R, Khoo, D, Khoo, S, Kiat, K, Kida, Y, Kim, J, Kitamura, N, Klenerman, P, Knight, S, Kobbe, R, Krishnan, V, Kumar, D, Kumar, G, Kurtzman, E, Lalueza, A, Lanza, M, Law, A, Lee, T, Lee, H, Lee, B, Lee, Y, Lee, J, Leeming, G, Lene, H, Leone, M, Bassi, G, Lim, K, Lim, W, Lina, L, Liu, K, Loforte, A, Loon, L, Lopes, D, Low, L, Loy, J, Bermejo, C, Lunn, M, Lyons, R, Maasikas, O, Machado, S, de la Calle, G, Maier, L, Malfertheiner, M, Malik, N, Sant'ana Malaque, C, Marino, D, Marques, A, Marsh, B, Marsh, L, Marshall, J, Martin, E, Martinez, F, Martin-Loeches, I, Martins, J, Martins, A, Rego, C, Martucci, G, Marzukie, M, Maynar, J, Mcarthur, C, Mccanny, P, Mccloskey, C, Mcdermott, S, Mcdonald, S, Mcelroy, A, Mcelwee, S, Mcevoy, N, Mckay, C, Mckeown, J, Mclean, K, Mele, F, Menkiti, O, Mentzer, A, Mergler, B, Merson, L, Mesquita, A, Meynert, A, Mihnovit, V, Miller, J, Misnan, N, Mohamed, T, Eliza Mohamed, N, Moin, A, Mone, M, Monteiro, A, Montes, C, Montrucchio, G, Moore, S, Motos, A, Muh, N, Muhamad, D, Murphy, A, Murthy, S, Muyandy, G, Nagpal, D, Nagrebetsky, A, Neto, R, Neumann, E, Ng, W, Choileain, O, Nichol, A, Nitayavardhana, P, Nonas, S, Mohd Noordin, N, Izzati Norharizam, N, Norman, L, Noursadeghi, M, Occhipinti, G, O'Donnell, M, Ogura, T, Oliveira, J, Olliaro, P, Ong, J, Oosthuyzen, W, Openshaw, P, Ortoleva, J, Osatnik, J, Othman, S, Palmarini, M, Panarello, G, Panda, P, Pang, L, Panigada, M, Parke, R, Patauner, F, Pathmanathan, M, Patterson, L, Paulos, J, Paxton, W, Peake, S, Peariasamy, K, Jimenez, M, Pelosi, P, Pereira, R, Periel, L, Pesenti, A, Pimentel, C, Pires, C, Pius, R, Png, H, Poli, S, Pollakis, G, Post, A, Postma, D, Povoa, P, Povoas, D, Preiser, J, Pritchard, M, Proenca, L, Semedi, B, Quesada, L, Quinones-Cardona, V, Gonzalez, V, Quraishi, M, Rafael, A, Rahman, R, Rahman, A, Rajahram, G, Ramalho, J, Ramli, A, Ramos, G, Rangappa, R, Ratsep, I, Rau, C, Ravi, T, Reis, R, Rello, J, Ren, H, Richardson, D, Ahmad Ridzuan, S, Rios, A, Robba, C, Roberto, A, Roberts, S, Robertson, D, Rodeia, S, Roessler, B, Roger, C, Rojek, A, Roncon-Albuquerque, R, Rose, M, Rosenberger, D, Rossetti, M, Russell, C, Ryckaert, S, Saba, I, Sadat, M, Sakiyalak, P, Salazar, L, Sales, G, Sanchez, E, Sancho-Shimizu, V, Sandhu, G, Santos, M, Satyapriya, S, Saviciute, E, Saw, Y, Schaffer, J, Schermer, T, Schwameis, M, Scott, J, Scott-Brown, J, Selvarajoo, M, Semple, M, Senian, R, Sequeira, F, Sequeira, T, Neto, A, Balazote, P, Shahidan, S, Shamsah, M, Sharma, P, Shaw, C, Shaw, V, Shetty, R, Shi, H, Shimizu, H, Shimizu, K, Shrapnel, S, Shum, H, Siang, N, Sigfrid, L, Sillaots, P, Silva, C, Heng, B, Singh, P, Singh, M, Sivam, K, Smith, S, Smood, B, Smyth, C, Snacken, M, Soh, T, Solomon, J, Solomon, T, Somers, E, Song, M, Sousa, M, Uva, M, Sperry, A, Sriskandan, S, Staudinger, T, Stecher, S, Stienstra, Y, Stolz, E, Stuart, A, Stuart, D, Suen, J, Summers, C, Suppiah, D, Syahrin, S, Sztajnbok, J, Szuldrzynski, K, Tabrizi, S, Taccone, F, Taib, S, Taleb, S, Talsma, J, Tan, K, Tan, Y, Tedder, R, Tee, T, Teixeira, J, Tejada, S, Teoh, S, Terpstra, P, Tessier-Grenier, H, Thabit, A, Tham, Z, Thangavelu, S, Thirumanickam, J, Thompson, S, Thomson, D, Thomson, E, Thorpe, M, Thurai, S, Thwaites, R, Toh, J, Tonnii, S, Torre, M, Torres, A, Towers, M, Trapani, T, Turtle, L, Udy, A, Ullrich, R, Uribe, A, Usman, A, Uyeki, T, Val-Flores, L, Van de Velde, S, Van Der Vekens, N, Van der Voort, P, Vanoverschelde, H, Vasudayan, S, Veeran, S, Ventura, S, Vidal, J, Vieira, C, Villanueva, J, Vitiello, C, Wahab, N, Wahab, S, Wahid, N, Wang, C, Webb, S, Wei, J, Wen, T, Wham, M, White, N, Wille, K, Williams, B, Williams, V, Williams, P, Wong, C, Wong, X, Wong, Y, Wong, T, Xian, G, Xian, L, Xuan, K, Mohd Yakop, S, Yamazaki, M, Yarad, E, Hing, N, Yeoh, C, Yerkovich, S, Yokoyama, T, Zaaqoq, A, Zahid, M, Binti Zaidan, N, Zambon, M, Zanella, A, Zaynah, N, Shah N., Xue B., Xu Z., Yang H., Marwali E., Dalton H., Payne P. P. R., Lu C., Said A. S., Abdukahil S. A., Abdulkadir N. N., Absil L., Acker A., Adriao D., Hssain A. A., Akwani C., Qasim E. A., Alalqam R., Al-Dabbous T., Alex B., Al-Fares A., Alfoudri H., Aliudin J., Alves J., Alves R., Alves J. M., Cabrita J. A., Amaral M., Amira N., Andini R., Anthonidass S., Antonelli M., Arabi Y., Arcadipane A., Arenz L., Arnold-Day C., Arora L., Arora R., Ashraf M., Asyraf A., Atique A., Bach B., Baillie J. K., Bak E., Bakar N. A., Balakrishnan M., Barbalho R., Barclay W. S., Barnett S. U., Barnikel M., Barrasa H., Barrigoto C., Baruch J., Hassin Basri M. F., Battaglini D., Bautista Rincon D. F., Bee K. H., Begum H., Beljantsev A., Benjiman L. E., Bento L., Bernal Sobrino J. L., Bertolino L., Bhatt A., Bianco C., Bidin F. N., Humaid F. B., Bin Kamarudin M. N., Blanco-Schweizer P., Bloos F., Boccia F., Bogaert D., Borges D., Bouhmani D., Bouziotis J., Boylan M., Bozza F. A., Brazzi L., Brewster D., Brickell K., Broadley T., Brozzi N., Buchtele N., Burrell A., Cabral S., Cabrita J., Garces R. C., Calligy K., Campbell P., Cardoso S., Cardoso F., Carelli S., Carrier F. M., Carson G., Cascao M., Casimiro J., Castanheira N., Castro I., Catarino A., Cavalin R., Cavalli G. G., Cavayas A., Chand M., Chen A., Chen Y. -S., Cheng M. P., Chica J., Chidambaram S. K., Tho L. C., Cho S. -M., Chow T. S., Chua H. J., Chua J., Cidade J. P., Citarella B. W., Ciullo A., Clarke J., Clohisey S., Codan C., Coles J., Colombo S. M., Connor M., Cooke G. S., Corley A., Cornelis S., Corpuz A. J., Crump J., Cruz C., Cruz Bermudez J. L., Rojo J. C., Csete M., Cullen A., Cummings M., Curley G., Custodio P., Filipe A. S., Dabaliz A. -A., Dagens A., Dahly D., Dalton J., Damas J., Dankwa E. A., Dantas J., de Loughry G., de Rosa R., de Silva T., Deacon J., Dean D., Debenedictis B., Dell'Amore A., Denis E., Depuydt P., Desai M., Dhangar P., Diaz R., Dieperink W., Docherty A. B., Doherty H., Donnelly C. A., Donohue C., Downer T., Drake T., Duculan T., Dunning J., Duplaix M., Durante-Mangoni E., Durham L., Ean S. C., Echeverria-Villalobos M., Elotmani L., Elshazly T., Eng C. C., Escher M., Santo C. E., Estevao J., Everding A. G., Fairfield C. J., Faria P., Fateena H., Fayed M., Fernandes J., Fernandes M. A., Fernandes S., Ferrao J., Ferraz M., Ferreira B., Figueiredo-Mello C., Fiorda J., Fletcher T., Florio L. L., Fonseca T., Forsyth S., Foti G., Fowler R. A., Fraser J. F., Fraser C., Ribeiro A. F., French C., Fukuda M., G A., Gagliardi M., Gaiao S., Gamble C., Gani Y., Garcia R., Barrio N. G., Gavin A., Germano N., Giani M., Gilroy E., Girvan M., Gnall E., Goffard J. -C., Goh J. Y., Golob J., Gonzalez A., Graf J., Grasselli G., Green C. A., Greenhalf W., Grieco D. L., Griffee M., Griffiths F., Lordemann A. G., Gruner H., Gu Y., Guerreiro D., Castro M. G., Hakak S., Hall M., Halpin S., Hamer A., Hammond T., Hammond N., Han L. Y., Hao K. W., Hardwick H., Ekow Harrison S. B., Harrison E. M., Harrison J., Heerman J., Hendry R., Hennessy M., Higgins D., Higgins R., Hinton S., Ho Y. B., Ho A., Hoh W. H., Holt R., Horby P., Hsu J. M. -Y., Hurd A., Ijaz S., Inacio H., Ing Y. S., Isgett S., Isidoro T., Ismail N., Ivulich D., Jackson C., Jelani A. M., Joe O. Y., Joshi S., Jung A., Kaisbain N., Kaleesvran T., Ayadi Kamaluddin M. A., Che Kamaruddin Z. A., Kamarudin N., Kang K. Y., Karpayah P., Kartsonaki C., Kay C., Keating S., Kelly A., Kelly S., Kennon K., Khalid I., Khan I., Kho M. E., Khoo R., Khoo D., Khoo S., Kiat K. H., Kida Y., Kim J. B., Kitamura N., Klenerman P., Knight S. R., Kobbe R., Krishnan V., Kumar D., Kumar G., Kurtzman E., Lalueza A., Lanza M., Law A., Lee T. C., Lee H. G., Lee B. H., Lee Y. L., Lee J., Leeming G., Lene H. S., Leone M., Bassi G. L., Lim K. C., Lim W. S., Lina L., Liu K., Loforte A., Loon L. C., Lopes D., Low L. L., Loy J. S., Bermejo C. L., Lunn M., Lyons R., Maasikas O., Machado S., de la Calle G. M., Maier L. S., Malfertheiner M., Malik N., Sant'ana Malaque C. M., Marino D., Marques A., Marsh B., Marsh L., Marshall J., Martin E., Martinez F. E., Martin-Loeches I., Martins J., Martins A., Rego C. M., Martucci G., Marzukie M., Maynar J., McArthur C., McCanny P., McCloskey C., McDermott S., McDonald S. E., McElroy A., McElwee S., McEvoy N., McKay C., McKeown J., McLean K. A., Mele F., Menkiti O., Mentzer A. J., Mergler B., Merson L., Mesquita A., Meynert A. M., Mihnovit V., Miller J., Misnan N. A., Mohamed T. J., Eliza Mohamed N. N., Moin A., Mone M., Monteiro A., Montes C., Montrucchio G., Moore S. C., Moore S., Motos A., Muh N. Y., Muhamad D., Murphy A., Murthy S., Muyandy G., Nagpal D., Nagrebetsky A., Neto R., Neumann E., Ng W. Y., Choileain O. N., Nichol A. D., Nitayavardhana P., Nonas S., Mohd Noordin N. A., Izzati Norharizam N. F., Norman L., Noursadeghi M., Occhipinti G., O'Donnell M., Ogura T., Oliveira J., Olliaro P. L., Ong J. Y., Oosthuyzen W., Openshaw P., Ortoleva J., Osatnik J., Othman S. Z., Palmarini M., Panarello G., Panda P. K., Pang L. H., Panigada M., Parke R., Patauner F., Pathmanathan M. D., Patterson L., Paulos J., Paxton W. A., Peake S. L., Peariasamy K., Jimenez M. P., Pelosi P., Pereira R., Periel L., Pesenti A., Pimentel C., Pires C., Pius R., Png H. S., Poli S., Pollakis G., Post A. -M., Postma D. F., Povoa P., Povoas D., Preiser J. -C., Pritchard M. G., Proenca L., Semedi B. P., Quesada L., Quinones-Cardona V., Gonzalez V. Q., Quraishi M., Rafael A., Rahman R. A., Rahman A. K. H. A., Rajahram G. S., Ramalho J., Ramli A. A., Ramos G. V., Rangappa R., Ratsep I., Rau C., Ravi T., Reis R., Rello J., Ren H., Richardson D., Ahmad Ridzuan S. N. A., Rios A. L., Robba C., Roberto A., Roberts S., Robertson D. L., Rodeia S., Roessler B., Roger C., Rojek A., Roncon-Albuquerque R., Rose M., Rosenberger D., Rossetti M., Russell C. D., Ryckaert S., Saba I., Sadat M., Sakiyalak P., Salazar L., Sales G., Sanchez E., Sancho-Shimizu V., Sandhu G., Santos M., Satyapriya S., Saviciute E., Saw Y. T., Schaffer J., Schermer T., Schwameis M., Scott J. T., Scott-Brown J., Selvarajoo M., Semple M. G., Senian R. B., Sequeira F., Sequeira T., Neto A. S., Balazote P. S., Shahidan S. A., Shamsah M., Sharma P., Shaw C. A., Shaw V., Shetty R. M., Shi H., Shimizu H., Shimizu K., Shrapnel S., Shum H. P., Siang N. Y., Sigfrid L., Sillaots P., Silva C., Heng B. S. L., Singh P., Singh M., Sivam K., Smith S., Smood B., Smyth C., Snacken M., Soh T. V., Solomon J., Solomon T., Somers E., Song M. J., Sousa M., Uva M. S., Sperry A., Sriskandan S., Staudinger T., Stecher S. -S., Stienstra Y., Stolz E., Stuart A., Stuart D., Suen J. 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B., Yamazaki M., Yarad E., Hing N. Y. L., Yeoh C. H., Yerkovich S., Yokoyama T., Zaaqoq A., Zahid M., Binti Zaidan N. Z., Zambon M., Zanella A., and Zaynah N.
- Abstract
Background: Veno-venous extracorporeal membrane oxygenation (V-V ECMO) is a lifesaving support modality for severe respiratory failure, but its resource-intensive nature led to significant controversy surrounding its use during the COVID-19 pandemic. We report the performance of several ECMO mortality prediction and severity of illness scores at discriminating survival in a large COVID-19 V-V ECMO cohort. Methods: We validated ECMOnet, PRESET (PREdiction of Survival on ECMO Therapy-Score), Roch, SOFA (Sequential Organ Failure Assessment), APACHE II (acute physiology and chronic health evaluation), 4C (Coronavirus Clinical Characterisation Consortium), and CURB-65 (Confusion, Urea nitrogen, Respiratory Rate, Blood Pressure, age >65 years) scores on the ISARIC (International Severe Acute Respiratory and emerging Infection Consortium) database. We report discrimination via Area Under the Receiver Operative Curve (AUROC) and Area under the Precision Recall Curve (AURPC) and calibration via Brier score. Results: We included 1147 patients and scores were calculated on patients with sufficient variables. ECMO mortality scores had AUROC (0.58–0.62), AUPRC (0.62–0.74), and Brier score (0.286–0.303). Roch score had the highest accuracy (AUROC 0.62), precision (AUPRC 0.74) yet worst calibration (Brier score of 0.3) despite being calculated on the fewest patients (144). Severity of illness scores had AUROC (0.52–0.57), AURPC (0.59–0.64), and Brier Score (0.265–0.471). APACHE II had the highest accuracy (AUROC 0.58), precision (AUPRC 0.64), and best calibration (Brier score 0.26). Conclusion: Within a large international multicenter COVID-19 cohort, the evaluated ECMO mortality prediction and severity of illness scores demonstrated inconsistent discrimination and calibration highlighting the need for better clinically applicable decision support tools.
- Published
- 2023
14. Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry
- Author
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B., Matan M., Mathieu D., Mattei M., Maulin L., Maxwell M., Maynar J., Mazzoni T., Sweeney L. M., McArthur C., McCanny P., McCarthy A., McCloskey C., McConnochie R., McDermott S., McDonald S. E., McElroy A., McElwee S., McEneany V., McEvoy N., McGeer A., McKay C., McKeown J., McLean K. A., McNally P., McNicholas B., McPartlan E., Meaney E., Mear-Passard C., Mechlin M., Mehkri O., Mele F., Melo L., Mendes J. J., Menon K., Mentre F., Mentzer A. J., Mercier E., Mercier N., Merckx A., Mergeay-Fabre M., Mergler B., Mesquita A., Metwally O., Meybeck A., Meyer D., Meynert A. M., Meysonnier V., Meziane A., Mezidi M., Michelanglei C., Michelet I., Mihelis E., Mihnovit V., Miller J., Miranda-Maldonado H., Misnan N. A., Mohamed T. J., Eliza Mohamed N. N., Moin A., Molinos E., Molloy B., Monahan S., Mone M., Monteiro A., Montes C., Montrucchio G., Moore S. C., Moore S., Cely L. M., Moro L., Morton B., Motherway C., Motos A., Mouquet H., Perrot C. M., Moyet J., Mudara C., Muh N. 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C., Lima C., Lina B., Lina L., Lind A., Lingas G., Lion-Daolio S., Lissauer S., Liu K., Livrozet M., Lizotte P., Lolong N., Loon L. C., Lopes D., Lopez-Colon D., Loschner A. L., Loubet P., Loufti B., Louis G., Lourenco S., Lee Low L., Lowik M., Loy J. S., Lucet J. -C., Bermejo C. L., Luna C. M., Lungu O., Luong L., Luque N., Luton D., Lwin N., Lyons R., Maasikas O., Mabiala O., Machado M., Machado S., Macheda G., Madiha H., de la Calle G. M., Mahieu R., Mahy S., Maia A. R., Maier L. S., Maillet M., Maitre T., Malfertheiner M., Malik N., Mallon P., Maltez F., Malvy D., Manda V., Mandelbrot L., Manetta F., Mankikian J., Manning E., Manuel A., Sant`Ana Malaque C. M., Marino F., Markowicz S., Marques A., Marquis C., Marsh B., Marsh L., Marshal M., Marshall J., Martelli C. T., Martin E., Martin-Blondel G., Martinez F. E., Martin-Loeches I., Martinot M., Martins J., Martins A., Martins N., Rego C. M., Martucci G., Martynenko O., Marwali E. M., Marzukie M., Maslove D., Mason S., Mat Nor M. B., Matan M., Mathieu D., Mattei M., Maulin L., Maxwell M., Maynar J., Mazzoni T., Sweeney L. M., McArthur C., McCanny P., McCarthy A., McCloskey C., McConnochie R., McDermott S., McDonald S. E., McElroy A., McElwee S., McEneany V., McEvoy N., McGeer A., McKay C., McKeown J., McLean K. A., McNally P., McNicholas B., McPartlan E., Meaney E., Mear-Passard C., Mechlin M., Mehkri O., Mele F., Melo L., Mendes J. J., Menon K., Mentre F., Mentzer A. J., Mercier E., Mercier N., Merckx A., Mergeay-Fabre M., Mergler B., Mesquita A., Metwally O., Meybeck A., Meyer D., Meynert A. M., Meysonnier V., Meziane A., Mezidi M., Michelanglei C., Michelet I., Mihelis E., Mihnovit V., Miller J., Miranda-Maldonado H., Misnan N. A., Mohamed T. J., Eliza Mohamed N. N., Moin A., Molinos E., Molloy B., Monahan S., Mone M., Monteiro A., Montes C., Montrucchio G., Moore S. C., Moore S., Cely L. M., Moro L., Morton B., Motherway C., Motos A., Mouquet H., Perrot C. M., Moyet J., Mudara C., Muh N. 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R., Yamazaki M., Yarad E., Yazdanpanah Y., Liang Hing N. Y., Yelnik C., Yeoh C. H., Yerkovich S., Yokoyama T., Yonis H., Yousif O., Zaaqoq A., Zabbe M., Zacharowski K., Zahid M., Zahran M., Binti Zaidan N. Z., Zambon M., Zambrano M., Zanella A., Zaynah N., Zayyad H., Zoufaly A., and Zucman D.
- Abstract
Background: COVID-19 has been associated with a broad range of thromboembolic, ischemic, and hemorrhagic complications (coagulopathy complications). Most studies have focused on patients with severe disease from high-income countries (HICs). Objectives: The main aims were to compare the frequency of coagulopathy complications in developing countries (low- and middle-income countries [LMICs]) with those in HICs, delineate the frequency across a range of treatment levels, and determine associations with in-hospital mortality. Methods: Adult patients enrolled in an observational, multinational registry, the International Severe Acute Respiratory and Emerging Infections COVID-19 study, between January 1, 2020, and September 15, 2021, met inclusion criteria, including admission to a hospital for laboratory-confirmed, acute COVID-19 and data on complications and survival. The advanced-treatment cohort received care, such as admission to the intensive care unit, mechanical ventilation, or inotropes or vasopressors; the basic-treatment cohort did not receive any of these interventions. Results: The study population included 495,682 patients from 52 countries, with 63% from LMICs and 85% in the basic treatment cohort. The frequency of coagulopathy complications was higher in HICs (0.76%-3.4%) than in LMICs (0.09%-1.22%). Complications were more frequent in the advanced-treatment cohort than in the basic-treatment cohort. Coagulopathy complications were associated with increased in-hospital mortality (odds ratio, 1.58; 95% CI, 1.52-1.64). The increased mortality associated with these complications was higher in LMICs (58.5%) than in HICs (35.4%). After controlling for coagulopathy complications, treatment intensity, and multiple other factors, the mortality was higher among patients in LMICs than among patients in HICs (odds ratio, 1.45; 95% CI, 1.39-1.51). Conclusion: In a large, international registry of patients hospitalized for COVID-19, coagulopathy complications were mo
- Published
- 2023
15. Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19
- Author
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A., Shamsah M., Shankar A., Sharjeel S., Sharma P., Shaw C. A., Shaw V., Sheenan J. R., Shi H., Shime N., Shimizu H., Shimizu K., Shum H. P., Mohammed N. S., Siang N. Y., Sibiude J., Siddiqui A., Sigfrid L., Sillaots P., Silva C., Silva R., Silva M. J., Lim Heng B. S., Sin W. C., Singh P., Singh B. C., Sitompul P. A., Sivam K., Skogen V., Smith S., Smood B., Smyth C., Smyth M., Snacken M., So D., Soh T. V., Solomon J., Solomon T., Somers E., Sommet A., Song R., Song M. J., Song T., Chia J. S., Sotto A., Soum E., Sousa M., Sousa A. C., Uva M. S., Souza-Dantas V., Sperry A., Spinuzza E., Sriskandan S., Stabler S., Staudinger T., Stecher S. -S., Steinsvik T., Stienstra Y., Stiksrud B., Stolz E., Stone A., Streinu-Cercel A., Stuart A., Stuart D., Su R., Subekti D., Suen G., Suen J. Y., Sukumar P., Sultana A., Summers C., Supic D., Suppiah D., Surovcova M., Svistunov S. A., Syahrin S., Syrigos K., Sztajnbok J., Szuldrzynski K., Tabrizi S., Taccone F. S., Tagherset L., Taib S. M., Taleb S., Talsma J., Tampubolon M. L., Tan K. K., Tan Y. C., Tanaka H., Tanaka T., Taniguchi H., Tardivon C., Tattevin P., Taufik M. A., Tawfik H., Tedder R. S., Tee T. Y., Teixeira J., Tellier M. -C., Teoh S. K., Teotonio V., Teoule F., Terpstra P., Terrier O., Terzi N., Tessier-Grenier H., Tey A., Mohd Thabit A. A., Tham Z. D., Thangavelu S., Theron E., Thibault V., Thiberville S. -D., Thill B., Thirumanickam J., Thompson S., Thomson D., Thomson E. C., Thorpe M., Thanga Thurai S. R., Thwaites R. S., Tierney P., Tieroshyn V., Timashev P. S., Timsit J. -F., Tissot N., Toal F., Yang Toh J. Z., Toki M., Tonby K., Tonnii S. L., Torre M., Torres A., Torres-Zevallos H., Towers M., Trapani T., Tromeur C., Trontzas I., Trouillon T., Truong J., Tual C., Tubiana S., Tuite H., Turgeon A. F., Turmel J. -M., Turtle L. C. W., Tveita A., Twardowski P., Udy A., Ullrich R., Uribe A., Usman A., Uyeki T. M., Vajdovics C., Val-Flores L., Valran A., Van de Velde S., van den Berge M., van der Palen J., van der Valk P., Van Der Vekens N., Van der Voort P., Van Der Werf S., van Gulik L., Van Hattem J., van Netten C., van Veen I., Vanel N., Vanoverschelde H., Varghese P., Varrone M., Vasudayan S. R., Vauchy C., Veeran S., Veislinger A., Vencken S., Ventura S., Verbon A., Vidal J. E., Vieira C., Villanueva J. A., Villoldo A., Visseaux B., Vitiello C., Vonkeman H., Vuotto F., Wahab N. H., Wahab S. A., Wahid N. A., Walsh L., Wang C. -H., Webb S., Wei J., Wen T. P., Wesselius S., Wham M., Whelan B., White N., Wicky P. H., Wiedemann A., Wijaya S. O., Wille K., Willems S., Williams B., Williams V., Williams P. J., Wils E. -J., Wittman J., Wong C., Wong X. C., Wong Y. S., Wong T. F., Xian G. E., Xian L. S., Kuan P. X., Xynogalas I., Binti Mohd Yakop S. R., Yamazaki M., Yarad E., Yazdanpanah Y., Liang Hing N. Y., Yelnik C., Yeoh C. H., Yerkovich S., Yokoyama T., Yonis H., Yousif O., Zaaqoq A., Zabbe M., Zahid M., Zahran M., Binti Zaidan N. Z., Zambon M., Zambrano M., Zanella A., Zaynah N., Zayyad H., Zoufaly A., and Zucman D.
- Abstract
Introduction: Acute kidney injury (AKI) has been identified as one of the most common and significant problems in hospitalized patients with COVID-19. However, studies examining the relationship between COVID-19 and AKI in low- and low-middle income countries (LLMIC) are lacking. Given that AKI is known to carry a higher mortality rate in these countries, it is important to understand differences in this population. Methods: This prospective, observational study examines the AKI incidence and characteristics of 32,210 patients with COVID-19 from 49 countries across all income levels who were admitted to an intensive care unit during their hospital stay. Results: Among patients with COVID-19 admitted to the intensive care unit, AKI incidence was highest in patients in LLMIC, followed by patients in upper-middle income countries (UMIC) and high-income countries (HIC) (53%, 38%, and 30%, respectively), whereas dialysis rates were lowest among patients with AKI from LLMIC and highest among those from HIC (27% vs. 45%). Patients with AKI in LLMIC had the largest proportion of community-acquired AKI (CA-AKI) and highest rate of in-hospital death (79% vs. 54% in HIC and 66% in UMIC). The association between AKI, being from LLMIC and in-hospital death persisted even after adjusting for disease severity. Conclusions: AKI is a particularly devastating complication of COVID-19 among patients from poorer nations where the gaps in accessibility and quality of healthcare delivery have a major impact on patient outcomes.
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- 2023
16. Impacto del primer año de tratamiento sustitutivo renal en la hospitalización de una comunidad autónoma
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López-Sánchez, Paula, Portolés, José, Martín Rodríguez, Leyre, Tornero, Fernando, Ramos Martín-Vegue, Arturo José, Herrero, José Antonio, and Cruz Bermúdez, Juan Luis
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- 2019
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17. Cancer-associated fibroblasts modify lung cancer metabolism involving ROS and TGF-β signaling
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Cruz-Bermúdez, Alberto, Laza-Briviesca, Raquel, Vicente-Blanco, Ramiro J., García-Grande, Aránzazu, Coronado, Maria José, Laine-Menéndez, Sara, Alfaro, Cristina, Sanchez, Juan Cristobal, Franco, Fernando, Calvo, Virginia, Romero, Atocha, Martin-Acosta, Paloma, Salas, Clara, Garcia, José Miguel, and Provencio, Mariano
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- 2019
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18. P1.27-07 BRAF Mutations Identify Non-small-Cell Lung Cancer Patients Who Benefit from Neoadjuvant Chemo-Immunotherapy
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Robado de Lope, L., primary, Nadal, E., additional, Calvo, V., additional, González-Larriba, J.L., additional, Insa, A., additional, Martinez-Marti, A., additional, Massutí, B., additional, González, C., additional, Serna Blasco, R., additional, Bosch-Barrera, J., additional, Garcia-Campelo, M.R., additional, Ponce, S., additional, Reguart, N., additional, Bernabé, R., additional, Cobo, M., additional, De Castro, J., additional, Dómine, M., additional, Camps, C., additional, Barneto, I., additional, López-Vivanco, G., additional, Majem, M., additional, Rodríguez-Abreu, D., additional, Palmero, R., additional, Cruz-Bermudez, A., additional, Romero, A., additional, and Provencio, M., additional
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- 2023
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19. Evaluation of the Perception of a University Group of Teachers about Education as a Social Phenomenon in Colombia
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Jorge Enrique Moreno-Collazos, Harold Fabián Cruz-Bermudez, Adriana Angarita-Fonseca, and Amparo Vélez-Ramírez
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Educación ,desarrollo ,historia ,investigación ,sociología ,Education ,Special aspects of education ,LC8-6691 - Abstract
Objective: This paper aims to evaluate the perception of a university group of teachers about education as a social phenomenon. An analytical cross-sectional study was conducted with a group of university teachers in Bogota, Colombia, in October 2014. A survey was applied in order to evaluate the perception about education as a social phenomenon; the data analysis was performed using SPSS software version 19. The population studied consisted of 60 university professors with an average age of 42.2 ± 14.4 years, and with 6.15 years of teaching practice. Male gender was predominant with 53% (n = 32). There were statistically significant differences in the results related to the concept of education (p = 0.05 to 0.00) and to the following items: “Do you consider that investment in public education is enough?” (p = 0.02), “Is education a political model?” (P = 0.03); in aggregate age, “Is access to higher education conceived by the Colombian government with social concern?”, “Does the environment influence the Colombian student’s education development?” (p = 0.02 to 0.00); it was the same case for the interpretive sociology for the item “Are patterns of educational assessment adequate in the country?” (p = 0.04). In conclusion, it was found that there are differences in teachers’ conceptions about the construction of education as a social phenomenon.f education as a social phenomenon by finding differences between the conceptions of it in teaching.
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- 2016
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20. 187P Tissue B-cell receptor repertoire as biomarker of complete pathological response in NSCLC patients treated with neoadjuvant chemoimmunotherapy (NADIM trials)
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B. Sierra-Rodero, C. Martínez-Toledo, M. Molina-Alejandre, V. Calvo, E. Nadal, B. Massuti Sureda, R. García Campelo, C. Gonzalez Ojea, A. Martinez-Marti, M. Domine Gomez, S. Ponce Aix, M.A. Insa Molla, J. De Castro Carpeno, M. Majem, I.C. Barneto Aranda, D. Rodriguez-Abreu, E. del Barco, M. Cobo Dols, M. Provencio Pulla, and A. Cruz-Bermudez
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Pulmonary and Respiratory Medicine ,Oncology - Published
- 2023
21. 939P Changes in immune gene signatures after neoadjuvant chemoimmunotherapy treatment in NSCLC patients from NADIM trial
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Casarrubios, M., primary, Cruz-Bermudez, A., additional, Sierra-Rodero, B., additional, Martinez, C., additional, Nadal, E., additional, Insa Molla, M.A., additional, Martinez, J. Mosquera, additional, Ojea, C. Gonzalez, additional, Gomez, M. Domine, additional, Tarruella, M. Majem, additional, Abreu, D. Rodriguez, additional, Martinez-Marti, A., additional, De Castro Carpeno, J., additional, Dols, M. Cobo, additional, Vivanco, G. Lopez, additional, Caro, R. Bernabe, additional, Segarra, N. Vinolas, additional, Aranda, I.C. Barneto, additional, Sureda, B. Massuti, additional, and Pulla, M. Provencio, additional
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- 2022
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22. P3.08E.04 TCR Metrics as Predictive Biomarkers of Response and Survival after Perioperative Chemoimmunotherapy. NADIM & NADIM II Trials
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Martínez-Toledo, C., Sierra, B., Molina-Alejandre, M., Casarrubios, M., Calvo, V., Nadal, E., García Campelo, M.R., Martínez-Martí, A., Garrido, A., Massutí, B., Insa, A., De Castro, J., Dómine, M., González-Larriba, J.L., Majem, M., Ponce, S., Barneto, I., Aguilar, A., Martín-López, J., Provencio, M., and Cruz- Bermúdez, A.
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- 2024
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23. P3.08E.01 Perioperative Chemoimmunotherapy Rescue Cold HLA-Deficient Tumors Inducing Strong Immune Responses and Long-Term Survival
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Molina-Alejandre, M., Perea, F., Calvo, V., Nadal, E., Huidobro, G., Martínez, C., Martínez-Martí, A., Sierra, B., Insa, A., Massutí, B., Aguilar, A., Barneto, I., Rodríguez - Abreu, D., De Castro Carpeño, J., García Campelo, M.R., Cobo, M., Wistuba, I., Parra, E.R., Martín-López, J., Megías, D., Muñoz-Viana, R., Casarrubios, M., Garrido, F., Aptsiauri, N., Ruiz-Cabello, F., Provencio, M., and Cruz- Bermúdez, A.
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- 2024
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24. MA01.08 Five-Year Clinical Outcomes of Perioperative Nivolumab and Chemotherapy in Stage III Non-Small-Cell Lung Cancer (NADIM Trial)
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Provencio, M., Nadal, E., Insa, A., Campelo, M.R. García, Calvo, V., Palmero, R., Lázaro, M., Dómine, M., Majem, M., Rodríguez - Abreu, D., Martínez-Martí, A., De Castro Carpeño, J., Cobo, M., Bernabé, R., Viñolas, N., Barneto, I., Viteri, S., Cruz-Bermúdez, A., Romero, A., and Massutí, B.
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- 2024
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25. OA12.05 APOLO: Phase II Trial of Induction Chemo-Immunotherapy Plus Chemoradiotherapy and Maintenance Immunotherapy in Stage III NSCLC
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Provencio, M., Campos, B., Guirado, M., Vilà, L., Campelo, M.R. García, Dorta, M., Vázquez Estévez, S., Ferrández, A., Sala, M.A., Ortega, A.L., Blasco, A., Insa, A., Areses, M.C., Sullivan, I., López Castro, R., Calvo, V., Rodríguez - Abreu, D., Bosch-Barrera, J., López-Martín, A., Marsé, R., Torrado, L., Matskov, K., Giner, J., Fernández Bruno, M., Sánchez Saugar, E., Martínez-Toledo, C., and Cruz-Bermudez, A.
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- 2024
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26. Profiling Lung Cancer Patients Using Electronic Health Records
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Menasalvas Ruiz, Ernestina, Tuñas, Juan Manuel, Bermejo, Guzmán, Gonzalo Martín, Consuelo, Rodríguez-González, Alejandro, Zanin, Massimiliano, González de Pedro, Cristina, Méndez, Marta, Zaretskaia, Olga, Rey, Jesús, Parejo, Consuelo, Cruz Bermudez, Juan Luis, and Provencio, Mariano
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- 2018
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27. Nivolumab + chemotherapy versus chemotherapy as neoadjuvant treatment for resectable stage IIIA NSCLC: Primary endpoint results of pathological complete response (pCR) from phase II NADIM II trial.
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Provencio-Pulla, Mariano, primary, Nadal, Ernest, additional, Larriba, Jose Luis Gonzalez, additional, Martinez-Marti, Alex, additional, Bernabé, Reyes, additional, Bosch-Barrera, Joaquim, additional, Casal, Joaquin, additional, Calvo, Virginia, additional, Insa, Amelia, additional, Aix, Santiago Ponce, additional, Reguart, Noemi, additional, Carpeño, Javier De Castro, additional, Mosquera, Joaquín, additional, Benitez, Raquel, additional, Aguado De La Rosa, Carlos, additional, Palmero, Ramon, additional, Hernando-Trancho, Florentino, additional, Romero, Atocha, additional, Cruz Bermudez, Alberto, additional, and Massuti, Bartomeu, additional
- Published
- 2022
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28. 939P Changes in immune gene signatures after neoadjuvant chemoimmunotherapy treatment in NSCLC patients from NADIM trial
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M. Casarrubios, A. Cruz-Bermudez, B. Sierra-Rodero, C. Martinez, E. Nadal, M.A. Insa Molla, J. Mosquera Martinez, C. Gonzalez Ojea, M. Domine Gomez, M. Majem Tarruella, D. Rodriguez Abreu, A. Martinez-Marti, J. De Castro Carpeno, M. Cobo Dols, G. Lopez Vivanco, R. Bernabe Caro, N. Vinolas Segarra, I.C. Barneto Aranda, B. Massuti Sureda, and M. Provencio Pulla
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Oncology ,Hematology - Published
- 2022
29. Building an i2b2-Based Population Repository for COVID-19 Research
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Miguel Pedrera-Jimenez, Noelia Garcia-Barrio, Gema Hernandez-Ibarburu, Blanca Baselga, Alvar Blanco, Fernando Calvo-Boyero, Alba Gutierrez-Sacristan, Víctor Quiros, Juan Luis Cruz-Bermudez, José Luis Bernal, Laura Meloni, David Perez-Rey, Matvey Palchuk, Isaac Kohane, and Pablo Serrano
- Abstract
Reuse of Electronic Health Records (EHRs) for specific diseases such as COVID-19 requires data to be recorded and persisted according to international standards. Since the beginning of the COVID-19 pandemic, Hospital Universitario 12 de Octubre (H12O) evolved its EHRs: it identified, modeled and standardized the concepts related to this new disease in an agile, flexible and staged way. Thus, data from more than 200,000 COVID-19 cases were extracted, transformed, and loaded into an i2b2 repository. This effort allowed H12O to share data with worldwide networks such as the TriNetX platform and the 4CE Consortium.
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- 2022
30. Building an i2b2-Based Population Repository for COVID-19 Research
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Miguel, Pedrera-Jimenez, Noelia, Garcia-Barrio, Gema, Hernandez-Ibarburu, Blanca, Baselga, Alvar, Blanco, Fernando, Calvo-Boyero, Alba, Gutierrez-Sacristan, Víctor, Quiros, Juan Luis, Cruz-Bermudez, José Luis, Bernal, Laura, Meloni, David, Perez-Rey, Matvey, Palchuk, Isaac, Kohane, and Pablo, Serrano
- Subjects
COVID-19 ,Electronic Health Records ,Humans ,Pandemics - Abstract
Reuse of Electronic Health Records (EHRs) for specific diseases such as COVID-19 requires data to be recorded and persisted according to international standards. Since the beginning of the COVID-19 pandemic, Hospital Universitario 12 de Octubre (H12O) evolved its EHRs: it identified, modeled and standardized the concepts related to this new disease in an agile, flexible and staged way. Thus, data from more than 200,000 COVID-19 cases were extracted, transformed, and loaded into an i2b2 repository. This effort allowed H12O to share data with worldwide networks such as the TriNetX platform and the 4CE Consortium.
- Published
- 2022
31. Making EHRs Trustable: A Quality Analysis of EHR-Derived Datasets for COVID-19 Research
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Miguel Pedrera-Jimenez, Noelia Garcia-Barrio, Paula Rubio-Mayo, Guillermo Maestro, Antonio Lalueza, Ana Garcia-Reyne, María José Zamorro, Alejandra Pons, María Jesús Sanchez-Martin, Jaime Cruz-Rojo, Víctor Quiros, José María Aguado, Juan Luis Cruz-Bermudez, José Luis Bernal, Laura Merson, Carlos Lumbreras, and Pablo Serrano
- Abstract
One approach to verifying the quality of research data obtained from EHRs is auditing how complete and correct the data are in comparison with those collected by manual and controlled methods. This study analyzed data quality of an EHR-derived dataset for COVID-19 research, obtained during the pandemic at Hospital Universitario 12 de Octubre. Data were extracted from EHRs and a manually collected research database, and then transformed into the ISARIC-WHO COVID-19 CRF model. Subsequently, a data analysis was performed, comparing both sources through this convergence model. More concepts and records were obtained from EHRs, and PPV (95% CI) was above 85% in most sections. In future studies, a more detailed analysis of data quality will be carried out.
- Published
- 2022
32. 157MO Immune gene signatures for predicting pathological response of NSCLC patients treated with neoadjuvant chemoimmunotherapy
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Casarrubios, M., primary, Cruz-Bermudez, A., additional, Sierra-Rodero, B., additional, Nadal, E., additional, Insa Molla, M.A., additional, Garcia Campelo, M.R., additional, Garcia Benito, C., additional, Domine Gomez, M., additional, Majem Tarruella, M., additional, Rodriguez-Abreu, D., additional, Martinez, A., additional, De Castro Carpeno, J., additional, Cobo Dols, M., additional, Lopez Vivanco, G., additional, Vinolas Segarra, N., additional, Barneto Aranda, I.C., additional, Viteri, S., additional, Massuti Sureda, B., additional, and Provencio Pulla, M., additional
- Published
- 2022
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33. Impact of first year renal replacement therapy on the hospital admissions of a regional public health system
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Paula López-Sánchez, José Portolés, Leyre Martín Rodríguez, Juan Luis Cruz Bermudez, Arturo Jose Ramos Martin-Vegue, Fernando Tornero, and José Antonio Herrero
- Subjects
Adult ,Male ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,030232 urology & nephrology ,030204 cardiovascular system & hematology ,lcsh:RC870-923 ,Institutional support ,Peritoneal dialysis ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Economic impact analysis ,Renal replacement therapy ,Dialysis ,Aged ,business.industry ,Public health ,Middle Aged ,lcsh:Diseases of the genitourinary system. Urology ,medicine.disease ,Hospitalization ,Renal Replacement Therapy ,Spain ,Nephrology ,Hospital admission ,Emergency medicine ,Kidney Failure, Chronic ,Female ,Public Health ,business ,Delivery of Health Care ,Kidney disease - Abstract
Introduction and objectives: Chronic kidney disease has a high prevalence and economic impact, and an increased risk of hospitalization. Although there are public regional and country registries, we have not found references to estimate the impact of renal replacement therapy (RRT) on hospital admissions. Methods: We obtained authorization from the ethics committee and health authorities to integrate the REMER [Madrid Kidney Disease Registry] (2013-2014) and Minimum Basic Data Set (2013-2015) databases and to analyze the admissions during the first year of RRT. Results: 767 patients started RRT in all the hospitals of our region across all RRT modalities. More than a third of the patients start dialysis during a hospital admission. This unplanned start, more common in HD than PD, shows relevant differences in patient profile or admission characteristics.Without considering this initial episode, almost 60% of patients were admitted during their first year. The hospitalization rate was 1.2 admissions/patient, higher in HD than in TX or PD; the mean length of stay was 8.6 days.The estimated cost of admissions during the first year is €12,006/patient. Our analysis ensures the exhaustive inclusion of all episodes and accurate estimation based on the discharge form. Conclusion: The impact of RRT on hospitals has been underestimated and is very relevant when calculating the total cost of RRT. Results from other countries cannot be extrapolated due to differences in the health system and patient profile. The integration of clinical databases could open up an opportunity that needs only institutional support for its development. Resumen: Introducción: y objetivos La enfermedad renal crónica tiene una alta prevalencia y coste, así como un mayor riesgo de ingreso. Disponemos de registros públicos y obligatorios, pero no hay referencias recientes para estimar el impacto que el tratamiento sustitutivo renal (TSR) tiene en la actividad hospitalaria. Métodos: Tras las autorizaciones pertinentes, hemos integrado las bases de datos REMER (2013-2014) y CMBDH (2013-2015) para analizar la actividad hospitalaria durante el primer año de TSR. Resultados: Un total de 767 pacientes iniciaron TSR en los 7 hospitales de tercer nivel de la Comunidad de Madrid. Más de una tercera parte lo hicieron de forma no programada durante un ingreso. Este inicio es más frecuente en HD que en DP, pero existen diferencias clínicas relevantes en edad y en comorbilidad. Descartando este primer episodio, casi el 60% de pacientes ingresan durante el primer año. La tasa de ingreso es de 1,2 ingresos/paciente, más alta en HD que en TX y DP; la estancia media es de 8,6 días. El coste agregado de los ingresos del primer año es de 12.006 €/paciente. Nuestro análisis asegura la inclusión exhaustiva de todos los episodios y la estimación precisa de costes. Conclusiones: El impacto del TSR en la actividad hospitalaria ha sido infraestimado y es una parte importante del coste global del TSR. Los resultados de la literatura internacional no pueden extrapolarse a nuestro país por las diferencias en el modelo sanitario y perfil de paciente. La integración de bases de datos clínicas es técnicamente viable y podría abrir una vía inmensa de información que solo requiere apoyo institucional para su desarrollo. Keywords: Renal replacement therapy, Hospital admission, Economic impact, Peritoneal dialysis, Haemodialysis, Transplant, Minimum Basic Data Set, Palabras clave: terapia sustitutiva renal, ingreso hospitalario, coste, diálisis peritoneal, hemodiálisis, trasplante, CMBDH
- Published
- 2019
34. Nivolumab + chemotherapy versus chemotherapy as neoadjuvant treatment for resectable stage IIIA NSCLC: Primary endpoint results of pathological complete response (pCR) from phase II NADIM II trial
- Author
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Mariano Provencio-Pulla, Ernest Nadal, Jose Luis Gonzalez Larriba, Alex Martinez-Marti, Reyes Bernabé, Joaquim Bosch-Barrera, Joaquin Casal, Virginia Calvo, Amelia Insa, Santiago Ponce Aix, Noemi Reguart, Javier De Castro Carpeño, Joaquín Mosquera, Raquel Benitez, Carlos Aguado De La Rosa, Ramon Palmero, Florentino Hernando-Trancho, Atocha Romero, Alberto Cruz Bermudez, and Bartomeu Massuti
- Subjects
Cancer Research ,Oncology - Abstract
8501 Background: Non-small cell lung cancer (NSCLC) is incurable in most patients with locally advanced stage IIIA disease. Previous results indicate that the use of neoadjuvant chemoimmunotherapy could increase the percentage of cured patients being a promising therapeutic option that has to be tested in randomized clinical trials. Methods: NADIM II (NCT03838159) is an open-label, randomized, two-arm, phase II, multi-center clinical trial. Patients with resectable clinical stage IIIA (per AJCC 7th ed) NSCLC, ECOG PS 0-1, and no known EGFR/ALK alterations were randomized to receive Nivolumab (NIVO) 360mg + Paclitaxel 200mg/m2 + Carboplatin AUC5 for 3 cycles every 21 days (+/- 3 days) as neoadjuvant treatment followed by surgery, or Paclitaxel 200mg/m2 + Carboplatin AUC5 for 3 cycles every 21 days (+/- 3 days) followed by surgery. Patients with R0 resection confirmed by pathological evaluation initiated adjuvant administration of NIVO within the 3rd to 8th week (+7 days) from surgery and for 6 months. The primary endpoint was pathological complete response (pCR) by blinded independent pathological review (BIPR) in the intent-to-treat population (ITT). pCR was defined as 0% viable tumor cells in resected lung and lymph nodes; patients who did not undergo surgery were classified as non-responders. Major pathological response (MPR; ≤ 10% viable tumor) per BIPR, overall response rate (ORR), toxicity profile, and potential predictive biomarkers are secondary endpoints. Results: Between February 8, 2019, and November 11, 2021, 90 patients were enrolled, of whom 87 patients were valid. Neoadjuvant NIVO + chemo significantly increased the pCR rate compared to chemo in the ITT (36.2% vs 6.8%; Relative Risk (RR) 5.25 [99% CI 1.32-20.87]; P = 0.0071). NIVO + chemo also improved MPR rates vs chemo in the ITT (52 % vs 14 %), as well as ORR (74 % vs 48%). Definitive surgery occurred for 91% of pts treated with NIVO + chemo and 69% with chemo; surgery was cancelled rarely due to AEs (1 pts/experimental arm) and due to disease progression in 1 and 4 pts in the experimental and control arm respectively. Grade 3-4-related AEs were reported in 24 % vs 10% in the NIVO + chemo vs chemo arms, respectively. In the ITT experimental arm, patients with pCR had higher PD-L1 TPS (median 70%, IQR 5-90%) compared to non-responders (median 0%, IQR 0-37.5%, P = 0.0035). AUC to predict pCR was 0.734 (95% CI 0.59-0.88; P = 0.005). The pCR rate rises across increasing categories of PD-L1 TPS ( < 1% 14.3%; 1-49% 41.7%; ≥50% 61.1%; P = 0.008). Conclusions: This study confirms the superiority of the chemo-immuno combination in patients with resectable stage IIIA NSCLC in terms of pCR, as well as the feasibility of surgery, with a moderate increase in grade 3-4 toxicity. Thus, this treatment should become the standard of care in these patients. Clinical trial information: NCT03838159.
- Published
- 2022
35. Pre-treatment tissue TCR repertoire evenness is associated with complete pathological response in patients with NSCLC receiving neoadjuvant chemoimmunotherapy
- Author
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Casarrubios M, Cruz-Bermudez A, Nadal E, Insa A, Garcia-Campelo R, Lazaro M, Domine M, Majem M, Rodriguez-Abreu D, Martinez-Marti A, de Castro-Carpeno J, Cobo M, Lopez-Vivanco G, Del Barco E, Bernabe Caro R, Vinolas N, Barneto Aranda I, Viteri S, Massuti B, Barquin M, Laza-Briviesca R, Sierra-Rodero B, Parra E, Sanchez-Espiridion B, Rocha P, Kadara H, Wistuba I, Romero A, Calvo V, and Provencio M
- Abstract
PURPOSE: Characterization of the T-cell receptor (TCR) repertoire may be a promising source for predictive biomarkers of pathological response to immunotherapy in locally-advanced non-small cell lung cancer (NSCLC). EXPERIMENTAL DESIGN: In this study, next-generation TCR sequencing was performed in peripheral blood and tissue samples of 40 NSCLC patients, before and after neoadjuvant chemoimmunotherapy (NADIM clinical trial, NCT03081689), considering their complete pathologic response (CPR) or non-CPR. Beyond TCR metrics, tissue clones were ranked by their frequency and spatiotemporal evolution of top 1% clones was determined. RESULTS: We have found a positive association between an uneven TCR repertoire in tissue samples at diagnosis and CPR at surgery. Moreover, TCR most frequent-ranked clones (top 1%) present in diagnostic biopsies occupied greater frequency in the total clonal space of CPR patients, achieving an AUC ROC to identify CPR patients of 0.967 (95% CI, 0.897 to 1.000; p=0.001), and improving the results of PD-L1 TPS (AUC 0.767; p=0.026) or TMB (AUC 0.550; p=0.687). Furthermore, tumors with high pre-treatment top 1% clonal space showed similar immune cell populations but a higher immune reactive gene expression profile. Finally, the selective expansion of pre-treatment tissue top 1% clones in peripheral blood of CPR patients suggests also a peripheral immunosurveillance, which could explain the high survival rate of these patients. CONCLUSIONS: We have identified two parameters derived from TCR repertoire analysis that could outperform PD-L1 TPS and TMB as predictive biomarkers of CPR after neoadjuvant chemoimmunotherapy, and unraveled possible mechanisms of CPR involving enhanced tumor immunogenicity and peripheral immunosurveillance.
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- 2021
36. Perfil Sensorial en niños con Trastorno Por Déficit De Atención e Hiperactividad
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Cristhian Santiago Bazan and Marco Antonio Jesus Cruz Bermudez
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Aprendizaje ,lcsh:R5-920 ,Trastorno por Déficit de Atención con Hiperactividad ,Modalidades Sensoriales ,Easily distracted ,Sensory system ,General Medicine ,Sensory profile ,medicine.disease ,Developmental disorder ,Treatment plan ,medicine ,Attention deficit ,Attention deficit hyperactivity disorder ,Observational study ,Psychology ,lcsh:Medicine (General) ,Clinical psychology - Abstract
Introduction. Coronavirus disease 2019 (COVID-19) is an acute respiratory infectious disease caused by the SARS-Cov-2 virus, which not only represents a great challenge, but is setting a precedent for the medical community. In this situation, it is suggested that all personnel who are exposed to occupational risks - specifically biological risk - will use the necessary personal and collective protection equipment provided by the institution or company for which they work. Workers in areas and jobs at high risk of infection can be stigmatized and discriminated, leading to their exclusion from the community and their increased exposure to violence and harassment. Objective. Analyze the occupational exposure to SARS-CoV-2 in health personnel in Latin America in May, 2020. Methods and materials. A quantitative, descriptive, cross-sectional study was carried out; a non-probabilistic sample of 713 volunteers participated. An online questionnaire of 30 closed questions was applied. Statistical analysis was performed using Excel 2019, using frequency analysis and central tendency measurements. The Helsinki bioethics recommendations were considered. Results and discussion. Health workers from 13 Spanish-speaking Latin American countries, from 7 professions in the health sector, participated. The personal and labor/institutional risk factors and repercussions on the personnel were detailed. Conclusions. Besides providing the necessary equipment and safety measures and protocols to the health workforce, it is fundamental that institutions adopt new collaborative policies that ensure the holistic protection (including psychological and emotional) of their workers.
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- 2020
37. 157MO Immune gene signatures for predicting pathological response of NSCLC patients treated with neoadjuvant chemoimmunotherapy
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M. Casarrubios, A. Cruz-Bermudez, B. Sierra-Rodero, E. Nadal, M.A. Insa Molla, M.R. Garcia Campelo, C. Garcia Benito, M. Domine Gomez, M. Majem Tarruella, D. Rodriguez-Abreu, A. Martinez, J. De Castro Carpeno, M. Cobo Dols, G. Lopez Vivanco, N. Vinolas Segarra, I.C. Barneto Aranda, S. Viteri, B. Massuti Sureda, and M. Provencio Pulla
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Oncology ,Hematology - Published
- 2022
38. Two cases of saturnine gout: APLAR-0403
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CONSIGNADO, J and CRUZ-BERMUDEZ, C CB
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- 2014
39. 81P Predictive molecular parameters of pneumonitis development in stage IIIa NSCLC patients treated with neo-adjuvant chemo-immunotherapy from NADIM clinical trial
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Sierra-Rodero, B., primary, Garitaonaindia, Y., additional, Martinez-Cutillas, M., additional, Nadal, E., additional, Insa, A., additional, Campelo, M.R. Garcia, additional, Rubio, J. Casal, additional, Gomez, M. Domine, additional, Tarruella, M. Majem, additional, Abreu, D. Rodriguez, additional, Martinez-Marti, A., additional, De Castro Carpeno, J., additional, del Barco, E., additional, Viñolas, N., additional, Aranda, I.C. Barneto, additional, Sureda, B. Massuti, additional, Casarrubios, M., additional, Laza-Briviesca, R., additional, Cruz-Bermudez, A., additional, and Provencio, M., additional
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- 2021
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40. P60.07 TMB and Selected Mutations in Resectable Stage IIIA NSCLC Patients Receiving Neo-Adjuvant Chemo-Immunotherapy from NADIM Trial
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Cruz-Bermudez, A., primary, Casarrubios, M., additional, Briviesca, R. Laza, additional, Nadal, E., additional, Insa, A., additional, Mosquera, J., additional, Huidobro, G., additional, Gómez, M. Dómine, additional, Massuti, B., additional, Tarruella, M. Majem, additional, Rodríguez-Abreu, D., additional, Martinez-Marti, A., additional, De Castro Campeño, J., additional, Dols, M. Cobo, additional, Vivanco, G. López, additional, Del Barco, E., additional, Caro, R. Bernabé, additional, Viñolas, N., additional, Barneto, I., additional, Viteri, S., additional, Jove, M., additional, Romero, A., additional, Franco, F., additional, and Provencio, M., additional
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- 2021
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41. P09.50 Lung Cancer Hospitalization Burden. Generating Knowledge from Administrative Data to Optimize Management
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Sanchez, J., primary, Nunez-Garcia, B., additional, Clemente, M. Blanco, additional, Cruz-Bermudez, J., additional, Mendez, M., additional, Cantos, B., additional, Garitaonaindía, Y., additional, Martin-Vegue, A. Ramos, additional, Calvo, V., additional, and Provencio, M., additional
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- 2021
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42. FP12.09 Molecular Insight into NADIM Clinical Trial: Potential Immune Biomarkers of Pathological Response for NSCLC Patients.
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Laza Briviesca, R., primary, Nadal, E., additional, Casarrubios, M., additional, Insa, A., additional, Sierra-Rodero, B., additional, Garcia Campelo, M.R., additional, Huidobro, G., additional, Dómine Gómez, M., additional, Massuti, B., additional, Majem, M., additional, Rodríguez-Abreu, D., additional, Martinez-Marti, A., additional, De Castro Campeño, J., additional, Cobo Dols, M., additional, López Vivanco, G., additional, Del Barco, E., additional, Bernabé Caro, R., additional, Viñolas, N., additional, Barneto, I., additional, Viteri, S., additional, Cruz-Bermudez, A., additional, and Provencio, M., additional
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- 2021
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43. P60.11 TCR Repertoire Predicts Pathological Response in NSCLC Patients Receiving Neoadjuvant Chemoimmunotherapy from NADIM Trial
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Casarrubios, M., primary, Nadal, E., additional, Cruz-Bermudez, A., additional, Insa, A., additional, Briviesca, R. Laza, additional, Campelo, M.R. Garcia, additional, Sierra-Rodero, B., additional, Casal, J., additional, Dómine, M., additional, Massuti, B., additional, Tarruella, M. Majem, additional, Rodríguez-Abreu, D., additional, Martinez-Marti, A., additional, De Castro Campeño, J., additional, Dols, M. Cobo, additional, Vivanco, G. López, additional, Del Barco, E., additional, Caro, R. Bernabé, additional, Viñolas, N., additional, Barneto, I., additional, Viteri, S., additional, Jove, M., additional, Franco, F., additional, and Provencio, M., additional
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- 2021
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44. ES06.01 Neoadjuvant IO Monotherapy vs. Chemo-IO
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Provencio, M., primary, Calvo, V., additional, Briviesca, R. Laza, additional, and Cruz-Bermudez, A., additional
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- 2021
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45. Perfil Sensorial en niños con Trastorno Por Déficit De Atención e Hiperactividad
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Santiago Bazán, Cristhian, Jesus Cruz Bermudez, Marco Antonio, Santiago Bazán, Cristhian, and Jesus Cruz Bermudez, Marco Antonio
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Introduction: Attention deficit hyperactivity disorder is a developmental disorder that affects behavior, is easily distracted, and has trouble concentrating and learning in children with it. Objective: To determine the sensory profile in children with attention dEficit and hyperactivity disorders. Material and Methods: It is a descriptive longitudinal and observational study, the required sample was 107 patients with Transtorno diagnosis for attention deficit and hyperactivity of both sexes and an age between 4 and 8 years of age, attended in the Clinical Home San Juan de Dios, the instrument used to measure the sensory profile was the Sensory Profile Test-2 , adapted to Peruvian reality, whose reliability was 0.885 alpha crombach. Results: Of the 107 patients with attention deficit hyperactivity disorder, the search sensory profile was observed as much as the others with 79.4%, the avoidative sensory profile more than the others with 41.1% and the like the others with 50.5%. Sensory sensitive profile was observed, more than the others with 49.5%. Likewise, we have the sensory profile spectator, we observed the levels "much more than the others" with 47.7%. Conclusions: The sensory profile is of paramount importance because it is part of the evaluation protocol and treatment plan of the patient with attention deficit and hyperactivity disorders, as well as in the prevention of problems in learning and school experience., Introducción: El trastorno por déficit de atención e hiperactividad,es un trastorno del desarrollo que afecta el comportamiento, se distraen con facilidad y tienen problemas para concentrarse y el aprendizaje en los niños en que lo padecen. Objetivo: Determinar el perfil sensorial en niños con transtornos por déficit de atención e hiperactividad. Material y Métodos: Es un estudio descriptivo de tipo longitudinal y observacional, la muestra requerida fue de 107 pacientes con diagnóstico Transtorno por déficit de atención e hiperactividad de ambos sexos y una edad comprendida entre 4 a 8 años de edad, atendidos en el Hogar Clínica San Juan de Dios, el instrumento utilizado para medir el perfil sensorial fue el Test Perfil Sensorial-2, adaptado a la realidad peruana, cuya confiabilidad fue de 0.885 alfa de crombach. Resultados: De los 107 pacientes con trastorno por déficit de atención e hiperactividad el perfil sensorial buscador se observó los niveles "mucho más que los demás" con 79,4%, el perfil sensorial evitativo "más que los demás" con 41,1 % y "como los demás" con 50,5%. Perfil sensorial sensitivo se observó, "más que los demás" con 49,5%. Así mismo, tenemos el perfil sensorial espectador, se observó los niveles "mucho más que los demás" con un 47,7%. Conclusiones: El perfil sensorial es de suma importancia porque forma parte del protocolo de evaluación y plan de tratamiento del paciente con transtornos por déficit de atención e hiperactividad, así como en la prevención de problemas en el aprendizaje y en la experiencia escolar.
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- 2020
46. Perfil Sensorial en niños con Trastorno Por Déficit De Atención e Hiperactividad
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Santiago, Cristhian, primary and Jesus Cruz Bermudez, Marco Antonio, additional
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- 2020
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47. P028 - CALIDAD DE VIDA TRAS SINOVIORTESIS RADIOISOTÓPICA EN PACIENTES CON ENFERMEDADES REUMÁTICAS CRÓNICAS
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Márquez, Mercedes Gallego, Chaparro, Javier Venero, Martínez, Francisco José Garí, Torrente, Miguel Sánchez, Morales, Cruz Bermúdez, García, Diego Becerra, and Torres, Dolores Martínez-Valle
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- 2023
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48. 187P Tissue B-cell receptor repertoire as biomarker of complete pathological response in NSCLC patients treated with neoadjuvant chemoimmunotherapy (NADIM trials)
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Sierra-Rodero, B., Martínez-Toledo, C., Molina-Alejandre, M., Calvo, V., Nadal, E., Sureda, B. Massuti, Campelo, R. García, Ojea, C. Gonzalez, Martinez-Marti, A., Gomez, M. Domine, Aix, S. Ponce, Molla, M.A. Insa, De Castro Carpeno, J., Majem, M., Aranda, I.C. Barneto, Rodriguez-Abreu, D., del Barco, E., Dols, M. Cobo, Pulla, M. Provencio, and Cruz-Bermudez, A.
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- 2023
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49. ctDNA analysis reveals different molecular patterns upon disease progression in patients treated with osimertinib
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Romero, Atocha, primary, Serna-Blasco, Roberto, additional, Alfaro, Cristina, additional, Sánchez-Herrero, Estela, additional, Barquín, Miguel, additional, Turpin, María Carmen, additional, Chico, Sofía, additional, Sanz-Moreno, Sandra, additional, Rodrigez-Festa, Alejandro, additional, Laza-Briviesca, Raquel, additional, Cruz-Bermudez, Alberto, additional, Calvo, Virginia, additional, Royuela, Ana, additional, and Provencio, Mariano, additional
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- 2020
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50. Peripheral blood T-cell receptor immune repertoire characterization of resectable stage IIIA non-small cell lung cancer patients receiving neo-adjuvant chemo-immunotherapy treatment from NADIM study.
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Cruz Bermudez, Alberto, primary, Casarrubios, Marta, additional, Laza Briviesca, Raquel, additional, Sierra-Rodero, Belen, additional, Barquin, Miguel, additional, Romero, Atocha, additional, Franco, Fernando, additional, Calvo, Virginia, additional, Nadal, Ernest, additional, Insa, Amelia, additional, Garcia-Campelo, Rosario, additional, Casal, Joaquin, additional, Domine, Manuel, additional, Massuti, Bartomeu, additional, Majem, Margarita, additional, Rodriguez-Abreu, Delvys, additional, Martinez-Marti, Alex, additional, De Castro, Javier, additional, and Provencio-Pulla, Mariano, additional
- Published
- 2020
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