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3. How Elon Musk backed away from his climate crusade

Author

Verma, Pranshu, Dwoskin, Elizabeth, Siddiqui, Faiz, and Osaka, Shannon

Subjects
Government regulation, Automobile Industry, Automobile industry -- Evaluation, Tax credits -- Laws, regulations and rules, Green technology -- Influence, Entrepreneurship -- Evaluation, Climatic changes -- Environmental aspects -- Influence, Businesspeople -- Evaluation, Environmental sustainability -- Influence, Tesla Inc. -- Evaluation
Abstract

Byline: Pranshu Verma, Elizabeth Dwoskin, Faiz Siddiqui, Shannon Osaka Earlier this year, top executives at Tesla gathered in Palo Alto to sell CEO Elon Musk on a line of compact [...]

Published
2024

4. Musk and Ramaswamy build a 'DOGE' team to go to war with Washington

Author

Dwoskin, Elizabeth, Stein, Jeff, Bogage, Jacob, and Siddiqui, Faiz

Subjects
Political consultants -- Beliefs, opinions and attitudes, United States. Department of Government Efficiency -- Powers and duties
Abstract

Byline: Elizabeth Dwoskin, Jeff Stein, Jacob Bogage, Faiz Siddiqui Elon Musk and Vivek Ramaswamy are interviewing job candidates and seeking advice from experts in Washington and Silicon Valley - pushing [...]

Published
2024

5. Trump aides explore plans to boost Musk effort by wresting control from Congress

Author

Stein, Jeff, Dwoskin, Elizabeth, Zakrzewski, Cat, and Bogage, Jacob

Subjects
Government regulation, Company business planning, Expenditures, Public -- Laws, regulations and rules, Administrative agencies -- Organization formation, United States. Congress -- Powers and duties
Abstract

Byline: Jeff Stein, Elizabeth Dwoskin, Cat Zakrzewski, Jacob Bogage President-elect Donald Trump's aides are readying unconventional strategies to implement at least some recommendations from a new government spending commission with [...]

Published
2024

6. Elon Musk says Trump win is just the start of his political ambitions

Author

Thadani, Trisha and Dwoskin, Elizabeth

Subjects
Entrepreneurship -- Beliefs, opinions and attitudes -- Political activity -- 2024 AD, Businesspeople -- Beliefs, opinions and attitudes -- Political activity -- 2024 AD, Ex-presidents -- Elections -- 2024 AD, Presidential elections (United States) -- 2024 AD, General interest, News, opinion and commentary
Abstract

Byline: Trisha Thadani, Elizabeth Dwoskin Elon Musk played a video game on his private jet as it hurtled toward Palm Beach, Florida, where he was due to watch election results [...]

Published
2024

7. Elon Musk will join Trump at Mar-a-Lago on election night

Author

Dwoskin, Elizabeth and Dawsey, Josh

Subjects
Company public relations, Billionaires -- Political activity, Presidential candidates -- Political activity -- Public relations
Abstract

Byline: Elizabeth Dwoskin, Josh Dawsey Tech billionaire Elon Musk is expected to spend election night with Donald Trump and his running mate, JD Vance, as wealthy donors descend on the [...]

Published
2024

8. Inside Elon Musk's vision to remake government: âDelete, delete, delete'

Author

Dwoskin, Elizabeth, Stein, Jeff, and Dawsey, Josh

Subjects
Personal finance, General interest, News, opinion and commentary
Abstract

Byline: Elizabeth Dwoskin, Jeff Stein, Josh Dawsey Taking the stage at former president Donald Trump's Madison Square Garden rally on Sunday, Elon Musk looked elated as the crowd chanted his [...]

Published
2024

9. Her billionaire marriage broke up. Her VP campaign fizzled. Now she's a Trump-world star

Author

Dwoskin, Elizabeth, Parker, Ashley, Kornfield, Meryl, and Schaffer, Aaron

Subjects
Electioneering -- Social aspects, Politicians -- Public relations, Political campaigns -- Social aspects, Presidential candidates -- Political activity -- Public relations, Company public relations, General interest, News, opinion and commentary
Abstract

Byline: Elizabeth Dwoskin, Ashley Parker, Meryl Kornfield, Aaron Schaffer During his recent live tour, Tucker Carlson welcomed a stable of MAGA warhorses to the stage: activist Charlie Kirk in Wichita, [...]

Published
2024

10. Inside the Harris campaign's blitz to win back Silicon Valley

Author

Zakrzewski, Cat, Tiku, Nitasha, and Dwoskin, Elizabeth

Subjects
Electioneering -- Forecasts and trends, High technology industry -- Industry forecasts -- Economic aspects, Political campaigns -- Forecasts and trends, Economic conditions -- Forecasts and trends, Presidential candidates -- Political activity, Market trend/market analysis, General interest, News, opinion and commentary
Abstract

Byline: Cat Zakrzewski, Nitasha Tiku, Elizabeth Dwoskin Key members of Kamala Harris's inner circle are deploying across the country for fundraisers, private meetings and meals as part of an aggressive [...]

Published
2024

11. Inside Elon Musk's plan to trigger a âred wave' for Trump

Author

Thadani, Trisha and Dwoskin, Elizabeth

Subjects
Electioneering, Billionaires -- Political activity, Political campaigns, Political action committees -- Political activity, Presidential candidates -- Political activity, General interest, News, opinion and commentary
Abstract

Byline: Trisha Thadani, Elizabeth Dwoskin NEW BERLIN, Wis. - As she prepared to knock on her first door of the day, Alysia McMillan switched her red MAGA hat for a [...]

Published
2024

12. Predicting Opioid Use Disorder from Longitudinal Healthcare Data using Multi-stream Transformer

Author

Fouladvand, Sajjad, Talbert, Jeffery, Dwoskin, Linda P., Bush, Heather, Meadows, Amy Lynn, Peterson, Lars E., Kavuluru, Ramakanth, and Chen, Jin

Subjects
Computer Science - Machine Learning, Computer Science - Artificial Intelligence
Abstract

Opioid Use Disorder (OUD) is a public health crisis costing the US billions of dollars annually in healthcare, lost workplace productivity, and crime. Analyzing longitudinal healthcare data is critical in addressing many real-world problems in healthcare. Leveraging the real-world longitudinal healthcare data, we propose a novel multi-stream transformer model called MUPOD for OUD identification. MUPOD is designed to simultaneously analyze multiple types of healthcare data streams, such as medications and diagnoses, by attending to segments within and across these data streams. Our model tested on the data from 392,492 patients with long-term back pain problems showed significantly better performance than the traditional models and recently developed deep learning models., Comment: This manuscript has been accepted by AMIA 2021 for oral presentation on November 1, 2021

Published
2021

15. What we know about the electronics explosions across Lebanon

Author

De Vynck, Gerrit, Westfall, Sammy, Dwoskin, Elizabeth, and Masih, Niha

Subjects
Hezbollah -- Military aspects -- Investigations, Company legal issue, Computer-linked pager, Paging technology, Explosions -- Casualties -- Investigations, Radio paging -- Investigations -- Usage, Radio pagers -- Investigations -- Usage, Attack and defense (Military science) -- Investigations -- Methods, Israel. Defense Forces -- Powers and duties
Abstract

Byline: Gerrit De Vynck, Sammy Westfall, Elizabeth Dwoskin, Niha Masih Thousands of pagers used by the militant group Hezbollah exploded across Lebanon at 3:30 p.m. on Tuesday, wounding as many [...]

Published
2024

16. What we know about the Hezbollah pagers attack

Author

De Vynck, Gerrit, Westfall, Sammy, and Dwoskin, Elizabeth

Subjects
Intelligence gathering, Political violence -- Forecasts and trends, Electronic surveillance, Explosions -- Investigations, Radio paging -- Usage, Radio pagers -- Usage, Company legal issue, Computer-linked pager, Market trend/market analysis, Paging technology, General interest, News, opinion and commentary, Hezbollah -- Political activity
Abstract

Byline: Gerrit De Vynck, Sammy Westfall, Elizabeth Dwoskin At 3:30 p.m. Tuesday in Lebanon, thousands of pagers used by the militant group Hezbollah exploded across the country, wounding at least [...]

Published
2024

17. Trump vs. Harris is dividing Silicon Valley into feuding political camps

Author

Thadani, Trisha, Dwoskin, Elizabeth, Tiku, Nitasha, and De Vynck, Gerrit

Subjects
Electioneering, High technology industry -- Political aspects, Political campaigns, Presidential candidates -- Political activity, Vice-Presidents -- Political activity, Company executive, General interest, News, opinion and commentary
Abstract

Byline: Trisha Thadani, Elizabeth Dwoskin, Nitasha Tiku, Gerrit De Vynck SAN FRANCISCO - In the 97 days before the election, billionaire investor Reid Hoffman is dedicating himself to a single [...]

Published
2024

18. Inside the powerful Peter Thiel network that anointed JD Vance

Author

Dwoskin, Elizabeth, Zakrzewski, Cat, Tiku, Nitasha, and Dawsey, Josh

Subjects
Venture capitalists (Persons) -- Political activity, Vice-Presidential candidates -- Endorsements, General interest, News, opinion and commentary
Abstract

Byline: Elizabeth Dwoskin, Cat Zakrzewski, Nitasha Tiku, Josh Dawsey - - - Correction: A previous version of this article incorrectly reported where Donald Trump praised Elon Musk; it was at [...]

Published
2024

19. The Silicon Valley realignment leading tech titans to Trump

Author

De Vynck, Gerrit, Dwoskin, Elizabeth, and Tiku, Nitasha

Subjects
Entrepreneurship -- Endorsements, Political action committees -- Finance, Businesspeople -- Endorsements, Presidential candidates -- Endorsements, Company financing, General interest, News, opinion and commentary, Republican Party (United States) -- Political activity
Abstract

Byline: Gerrit De Vynck, Elizabeth Dwoskin, Nitasha Tiku SAN FRANCISCO - A wave of Silicon Valley leaders has publicly lined up behind Donald Trump since Saturday's assassination attempt - including [...]

Published
2024

20. Elon Musk allies poured millions into pro-Trump super PAC

Author

Siddiqui, Faiz and Dwoskin, Elizabeth

Subjects
Electioneering -- Forecasts and trends, Campaign funds -- Forecasts and trends, Chief executive officers -- Donations, Political campaigns -- Forecasts and trends, Political action committees -- Donations, Presidential candidates -- Political activity -- Finance, Company financing, Market trend/market analysis, General interest, News, opinion and commentary
Abstract

Byline: Faiz Siddiqui, Elizabeth Dwoskin America PAC, a super PAC aligned with Trump, reported on Monday that it received donations ranging from $500,000 to $1 million from prominent tech titans, [...]

Published
2024

21. Musk, other pro-Trump billionaires have helped shape shooting narrative

Author

Dwoskin, Elizabeth and Siddiqui, Faiz

Subjects
Shooting -- Political aspects, Billionaires -- Beliefs, opinions and attitudes -- Endorsements, Presidential candidates -- Crimes against -- Endorsements, General interest, News, opinion and commentary
Abstract

Byline: Elizabeth Dwoskin, Faiz Siddiqui A chorus of right-leaning tech and business leaders, led by X owner Elon Musk, used their online megaphones in the wake of Saturday's attack to [...]

Published
2024

23. Doctors couldn't help. They turned to a shadow system of DIY medical tests

Author

Dwoskin, Elizabeth, Gilbert, Daniel, and Hunter, Tatum

Subjects
Home medical tests -- Usage -- Product development, Medical test kit industry -- Forecasts and trends -- Product development, Medical equipment and supplies industry -- Forecasts and trends -- Product development, Market trend/market analysis, General interest, News, opinion and commentary
Abstract

Byline: Elizabeth Dwoskin, Daniel Gilbert, Tatum Hunter Angelika Sharma was desperate. An array of basic first foods - from bananas to sweet potatoes - caused her six-month old Annika to [...]

Published
2024

24. Trump gets $1 million from Silicon Valley donor who once gave to Democrats

Author

Dwoskin, Elizabeth and Reston, Maeve

Subjects
Electioneering, Political fund raising, Entrepreneurship -- Donations -- Political activity, Political campaigns, Businesspeople -- Donations -- Political activity, Presidential candidates -- Political activity, General interest, News, opinion and commentary
Abstract

Byline: Elizabeth Dwoskin, Maeve Reston - - - Correction: A previous version of this article incorrectly said Rick Scott is governor of Florida. He is a U.S. senator. The article [...]

Published
2024

25. How the authoritarian Middle East became the capital of Silicon Valley

Author

Dwoskin, Elizabeth, Nakashima, Ellen, Tiku, Nitasha, and Zakrzewski, Cat

Subjects
High technology industry, Entrepreneurship, Businesspeople, General interest, News, opinion and commentary
Abstract

Byline: Elizabeth Dwoskin, Ellen Nakashima, Nitasha Tiku, Cat Zakrzewski Two years ago, Andrew Feldman couldn't find Abu Dhabi on a map. But like many Silicon Valley leaders, the artificial intelligence [...]

Published
2024

26. How the push to ban TikTok spurred a new Washington influence machine

Author

Dwoskin, Elizabeth, Harwell, Drew, and Zakrzewski, Cat

Subjects
TikTok Inc. -- Laws, regulations and rules -- Mergers, acquisitions and divestments, Computer services industry -- Laws, regulations and rules -- Mergers, acquisitions and divestments, Consultants -- Political activity, Online social networks -- Laws, regulations and rules -- Censorship -- Political aspects, Government regulation, Company acquisition/merger, Computer services industry, General interest, News, opinion and commentary, TikTok (Online social network) -- Political aspects -- Censorship -- Laws, regulations and rules
Abstract

Byline: Elizabeth Dwoskin, Drew Harwell, Cat Zakrzewski Two years ago, Jacob Helberg, a little-known tech industry adviser, convened a dinner between lawmakers and a small group of Silicon Valley insiders [...]

Published
2024

27. The tech billionaires who helped ban TikTok want to write AI rules for Trump

Author

Dwoskin, Elizabeth, Harwell, Drew, and Zakrzewski, Cat

Subjects
Rich, High technology industry, Venture capital companies, Social networks, General interest, News, opinion and commentary
Abstract

Byline: Elizabeth Dwoskin, Drew Harwell, Cat Zakrzewski Two years ago, Jacob Helberg, a little-known tech industry adviser, convened a dinner between lawmakers and a small group of Silicon Valley insiders [...]

Published
2024

28. Having remade Twitter, Musk takes his speech fight global

Author

Dwoskin, Elizabeth, McCoy, Terrence, and Dias, Marina

Subjects
Freedom of speech, Disinformation, Democracy -- Brazil, General interest, News, opinion and commentary, Twitter (Online social network)
Abstract

Byline: Elizabeth Dwoskin, Terrence McCoy, Marina Dias SAN FRANCISCO - To Elon Musk, the Brazilian Supreme Court justice is a Ç£dictator.Ç¥ In the justiceÇÖs view, Musk is allowing his social [...]

Published
2024

29. OpenAI prepares to fight for its life as legal troubles mount

Author

Zakrzewski, Cat, Tiku, Nitasha, and Dwoskin, Elizabeth

Subjects
Comedians, Governmental investigations, General interest, News, opinion and commentary
Abstract

Byline: Cat Zakrzewski, Nitasha Tiku, Elizabeth Dwoskin As OpenAIÇÖs top executives huddled with world leaders this past summer - touting the benefits of its ChatGPT with Indian Prime Minister Narendra [...]

Published
2024

32. Mnuchinâs plan to buy TikTok has some insiders bewildered

Author

Dwoskin, Elizabeth and Harwell, Drew

Subjects
Government regulation of business, General interest, News, opinion and commentary
Abstract

Byline: Elizabeth Dwoskin, Drew Harwell Former treasury secretary Steven Mnuchin is telling rich investors he has a plan to take over TikTok: rebuild the wildly popular video app from scratch. [...]

Published
2024

33. Many GOP billionaires balked at Jan. 6. Theyâre coming back to Trump

Author

Dawsey, Josh, Stein, Jeff, Scherer, Michael, and Dwoskin, Elizabeth

Subjects
Rich -- Political activity -- Political aspects, General interest, News, opinion and commentary
Abstract

Byline: Josh Dawsey, Jeff Stein, Michael Scherer, Elizabeth Dwoskin The day after a pro-Trump mob stormed the Capitol on Jan. 6, 2021, billionaire and GOP megadonor Nelson Peltz called the [...]

Published
2024

34. How a liberal billionaire became Americaâs leading anti-DEI crusader

Author

Dwoskin, Elizabeth

Subjects
Hedge funds, General interest, News, opinion and commentary, Harvard University
Abstract

Byline: Elizabeth Dwoskin CORRECTION: A previous version of this article incorrectly reported that Bill Ackman was a board member of the real estate company that owned Rockefeller Center. He was [...]

Published
2024

35. How Silicon Valley learned to love America, drones and glory

Author

Tiku, Nitasha and Dwoskin, Elizabeth

Subjects
General interest, News, opinion and commentary
Abstract

Byline: Nitasha Tiku, Elizabeth Dwoskin Hundreds of bright young technologists have landed in California this weekend for a two-day hackathon - a quintessential start-up contest in which teams of coders [...]

Published
2024

36. Inside Meta, a debate over when the word âZionistâ is hate speech

Author

Nix, Naomi and Dwoskin, Elizabeth

Subjects
Israel-Arab conflicts, General interest, News, opinion and commentary
Abstract

Byline: Naomi Nix, Elizabeth Dwoskin Meta is debating whether to more aggressively remove some social media posts containing the words âZionistâ to counter a surge of antisemitism online, setting up [...]

Published
2024

37. Mark Zuckerberg joins struggle over Harvardâs future

Author

Dwoskin, Elizabeth and Svrluga, Susan

Subjects
General interest, News, opinion and commentary, Harvard University
Abstract

Byline: Elizabeth Dwoskin, Susan Svrluga Meta CEO Mark Zuckerberg jumped into the fight over Harvard Universityâs future on Friday, the latest prominent business leader to do so at a moment [...]

Published
2024

38. OpenAI suspends bot developer for presidential hopeful Dean Phillips

Author

Dwoskin, Elizabeth

Subjects
Electioneering, Political campaigns, Political action committees, Presidential candidates, General interest, News, opinion and commentary
Abstract

Byline: Elizabeth Dwoskin The artificial intelligence company OpenAI banned the developer of a bot mimicking long shot Democratic presidential hopeful Rep. Dean Phillips - the first action that the maker [...]

Published
2024

39. How the internet is erasing the Oct. 7 Hamas massacre

Author

Dwoskin, Elizabeth

Subjects
Foreign policy -- Reports, Violence -- Reports, Social networks -- Reports, Massacres -- Reports, General interest, News, opinion and commentary
Abstract

Byline: Elizabeth Dwoskin When she first heard about HamasÇÖ Oct. 7 attack on Israel, Mirela Monte was Ç£appalled.Ç¥ The South Carolina real estate agent and self-described holistic healer detests violence [...]

Published
2024

40. OpenAI bans developer of bot for presidential hopeful Dean Phillips

Author

Dwoskin, Elizabeth

Subjects
Electioneering, Political campaigns, Political action committees, Presidential candidates, General interest, News, opinion and commentary
Abstract

Byline: Elizabeth Dwoskin The artificial intelligence company OpenAI banned the developer of a bot impersonating long shot Democratic presidential hopeful Rep. Dean Phillips - the first action that the maker [...]

Published
2024

41. Silicon Valley insiders are trying to unseat Biden with help from AI

Author

Kornfield, Meryl and Dwoskin, Elizabeth

Subjects
Political parties -- New Hampshire, Political action committees -- Political aspects, General interest, News, opinion and commentary
Abstract

Byline: Meryl Kornfield and Elizabeth Dwoskin Stopping New Hampshire voters on the sidewalk, refilling their coffee mugs at diners and repeating his stump speech, long-shot presidential candidate Dean Phillips - [...]

Published
2024

44. Glycemic Control and Urinary Tract Infections in Women with Type 1 Diabetes: Results from the DCCT/EDIC

Author

Lenherr, Sara M, Clemens, J Quentin, Braffett, Barbara H, Cleary, Patricia A, Dunn, Rodney L, Hotaling, James M, Jacobson, Alan M, Kim, Catherine, Herman, William, Brown, Jeanette S, Wessells, Hunter, Sarma, Aruna V, Nathan, DM, Zinman, B, Crofford, O, Genuth, S, Brown-Friday, J, Crandall, J, Engel, H, Engel, S, Martinez, H, Phillips, M, Reid, M, Shamoon, H, Sheindlin, J, Gubitosi-Klug, R, Mayer, L, Pendegast, S, Zegarra, H, Miller, D, Singerman, L, Smith-Brewer, S, Novak, M, Quin, J, Genuth, Saul, Palmert, M, Brown, E, McConnell, J, Pugsley, P, Crawford, P, Dahms, W, Brillon, D, Lackaye, ME, Kiss, S, Chan, R, Orlin, A, Rubin, M, Reppucci, V, Lee, T, Heinemann, M, Chang, S, Levy, B, Jovanovic, L, Richardson, M, Bosco, B, Dwoskin, A, Hanna, R, Barron, S, Campbell, R, Bhan, A, Kruger, D, Jones, JK, Edwards, PA, Carey, JD, Angus, E, Thomas, A, Galprin, A, McLellan, M, Whitehouse, F, Bergenstal, R, Johnson, M, Gunyou, K, Thomas, L, Laechelt, J, Hollander, P, Spencer, M, Kendall, D, Cuddihy, R, Callahan, P, List, S, Gott, J, Rude, N, Olson, B, Franz, M, Castle, G, Birk, R, Nelson, J, Freking, D, Gill, L, Mestrezat, W, Etzwiler, D, Morgan, K, Aiello, LP, Golden, E, Arrigg, P, Asuquo, V, Beaser, R, Bestourous, L, and Cavallerano, J

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Infectious Diseases, Clinical Research, Urologic Diseases, Diabetes, Prevention, Reproductive health and childbirth, Renal and urogenital, Infection, Metabolic and endocrine, Adolescent, Adult, Blood Glucose, Body Mass Index, Diabetes Mellitus, Type 1, Female, Glycated Hemoglobin, Humans, Hypoglycemic Agents, Risk Factors, Surveys and Questionnaires, Urinary Incontinence, Urinary Tract Infections, Young Adult, DCCT/EDIC Research Group, diabetes mellitus, risk factors, urinary tract infections, Clinical Sciences, Urology & Nephrology, Clinical sciences
Abstract

PurposeWe examined the relationship between glycemic control and urinary tract infections in women with type 1 diabetes mellitus.Materials and methodsWomen enrolled in the Epidemiology of Diabetes Interventions and Complications study, the observational followup of the Diabetes Control and Complications Trial, were surveyed to assess the rate of physician diagnosed urinary tract infections in the preceding 12 months. The relationship between glycated hemoglobin levels and number of urinary tract infections in the previous 12 months was assessed using a multivariable Poisson regression model.ResultsA total of 572 women were evaluated at year 17. Mean age was 50.7 ± 7.2 years, mean body mass index was 28.6 ± 5.9 kg/m(2), mean type 1 diabetes duration was 29.8 ± 5.0 years and mean glycated hemoglobin was 8.0% ± 0.9%. Of these women 86 (15.0%) reported at least 1 physician diagnosed urinary tract infection during the last 12 months. Higher glycated hemoglobin levels were significantly associated with number of urinary tract infections such that for every unit increase (1%) in recent glycated hemoglobin level, there was a 21% (p=0.02) increase in urinary tract infection frequency in the previous 12 months after adjusting for race, hysterectomy status, urinary incontinence, sexual activity in the last 12 months, peripheral and autonomic neuropathy, and nephropathy.ConclusionsThe frequency of urinary tract infections increases with poor glycemic control in women with type 1 diabetes. This relationship is independent of other well described predictors of urinary tract infections and suggests that factors directly related to glycemic control may influence the risk of lower urinary tract infections.

Published
2016

45. Epigenomic profiling reveals an association between persistence of DNA methylation and metabolic memory in the DCCT/EDIC type 1 diabetes cohort

Author

Chen, Zhuo, Miao, Feng, Paterson, Andrew D, Lachin, John M, Zhang, Lingxiao, Schones, Dustin E, Wu, Xiwei, Wang, Jinhui, Tompkins, Joshua D, Genuth, Saul, Braffett, Barbara H, Riggs, Arthur D, Natarajan, Rama, Nathan, DM, Zinman, B, Crofford, O, Genuth, S, Brown-Friday, J, Crandall, J, Engel, H, Engel, S, Martinez, H, Phillips, M, Reid, M, Shamoon, H, Sheindlin, J, Gubitosi-Klug, R, Mayer, L, Pendegast, S, Zegarra, H, Miller, D, Singerman, L, Smith-Brewer, S, Novak, M, Quin, J, Palmert, M, Brown, E, McConnell, J, Pugsley, P, Crawford, P, Dahms, W, Brillon, D, Lackaye, ME, Kiss, S, Chan, R, Orlin, A, Rubin, M, Reppucci, V, Lee, T, Heinemann, M, Chang, S, Levy, B, Jovanovic, L, Richardson, M, Bosco, B, Dwoskin, A, Hanna, R, Barron, S, Campbell, R, Bhan, A, Kruger, D, Jones, JK, Edwards, PA, Carey, JD, Angus, E, Thomas, A, Galprin, A, McLellan, M, Whitehouse, F, Bergenstal, R, Johnson, M, Gunyou, K, Thomas, L, Laechelt, J, Hollander, P, Spencer, M, Kendall, D, Cuddihy, R, Callahan, P, List, S, Gott, J, Rude, N, Olson, B, Franz, M, Castle, G, Birk, R, Nelson, J, Freking, D, Gill, L, Mestrezat, W, Etzwiler, D, Morgan, K, Aiello, LP, Golden, E, Arrigg, P, Asuquo, V, Beaser, R, and Bestourous, L

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Clinical Research, Diabetes, Human Genome, Nutrition, Autoimmune Disease, Prevention, 2.1 Biological and endogenous factors, Metabolic and endocrine, Adolescent, Adult, Carrier Proteins, Cell Line, Tumor, Cohort Studies, DNA Methylation, Diabetes Mellitus, Type 1, Epigenomics, Female, Genetic Loci, Glycated Hemoglobin, Humans, Male, DCCT/EDIC Research Group, DNA methylation, TXNIP, diabetic complications, epigenetics, metabolic memory
Abstract

We examined whether persistence of epigenetic DNA methylation (DNA-me) alterations at specific loci over two different time points in people with diabetes are associated with metabolic memory, the prolonged beneficial effects of intensive vs. conventional therapy during the Diabetes Control and Complications Trial (DCCT) on the progression of microvascular outcomes in the long-term follow-up Epidemiology of Diabetes Interventions and Complications (EDIC) Study. We compared DNA-me profiles in genomic DNA of whole blood (WB) isolated at EDIC Study baseline from 32 cases (DCCT conventional therapy group subjects showing retinopathy or albuminuria progression by EDIC Study year 10) vs. 31 controls (DCCT intensive therapy group subjects without complication progression by EDIC year 10). DNA-me was also profiled in blood monocytes (Monos) of the same patients obtained during EDIC Study years 16-17. In WB, 153 loci depicted hypomethylation, and 225 depicted hypermethylation, whereas in Monos, 155 hypomethylated loci and 247 hypermethylated loci were found (fold change ≥1.3; P < 0.005; cases vs. controls). Twelve annotated differentially methylated loci were common in both WB and Monos, including thioredoxin-interacting protein (TXNIP), known to be associated with hyperglycemia and related complications. A set of differentially methylated loci depicted similar trends of associations with prior HbA1c in both WB and Monos. In vitro, high glucose induced similar persistent hypomethylation at TXNIP in cultured THP1 Monos. These results show that DNA-me differences during the DCCT persist at certain loci associated with glycemia for several years during the EDIC Study and support an epigenetic explanation for metabolic memory.

Published
2016

47. Think your credit card rate is high? Some in Brazil pay 455 percent

Author

Dwoskin, Elizabeth and Pessoa, Gabriela Sa

Subjects
Brazil -- Economic aspects, Credit and debit card industry -- Prices and rates, Interest rates -- Statistics -- Economic aspects, Credit cards -- Economic aspects, Company pricing policy, General interest, News, opinion and commentary
Abstract

Byline: Elizabeth Dwoskin and Gabriela Sa Pessoa PORTO ALEGRE, Brazil - Ady Chaves opened her bank statement reluctantly. In the fine print of the lengthy credit card contract was the [...]

Published
2023

48. 'King of the cannibals': How Sam Altman took over Silicon Valley

Author

Dwoskin, Elizabeth, Fisher, Marc, and Tiku, Nitasha

Subjects
General interest, News, opinion and commentary
Abstract

Byline: Elizabeth Dwoskin, Marc Fisher and Nitasha Tiku Several weeks before he was ousted as CEO of OpenAI, Sam Altman called up his longtime mentor, billionaire Peter Thiel, to talk [...]

Published
2023

49. Altman's polarizing past hints at OpenAI board's reason for firing him

Author

Dwoskin, Elizabeth and Tiku, Nitasha

Subjects
OpenAI -- Officials and employees -- Services, Chief executive officers -- Appointments, resignations and dismissals, Information services industry -- Officials and employees -- Services, Information services -- Officials and employees -- Services, Information services industry, General interest, News, opinion and commentary
Abstract

Byline: Elizabeth Dwoskin and Nitasha Tiku Friday's shocking ouster of Sam Altman, who negotiated his return as CEO of OpenAI late Tuesday night, was not the first time the shrewd [...]

Published
2023

50. Sam Altman's been fired before. The polarizing past of OpenAI's reinstated CEO

Author

Dwoskin, Elizabeth and Tiku, Nitasha

Subjects
OpenAI -- Officials and employees, Computer software industry -- Officials and employees, Chief executive officers -- Appointments, resignations and dismissals -- Evaluation, General interest, News, opinion and commentary
Abstract

Byline: Elizabeth Dwoskin and Nitasha Tiku Friday's shocking ouster of Sam Altman, who negotiated his return as CEO of OpenAI late Tuesday night, was not the first time the shrewd [...]

Published
2023

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