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1. Supports of quasi-copulas

Author

Fernández-Sánchez, Juan, Quesada-Molina, José Juan, and Úbeda-Flores, Manuel

Subjects
Mathematics - Dynamical Systems, Mathematics - Probability, 60E05, 62E10
Abstract

It is known that for every $s\in]1,2[$ there is a copula whose support is a self-similar fractal set with Hausdorff -- and box-counting -- dimension $s$. In this paper we provide similar results for (proper) quasi-copulas, in both the bivariate and multivariate cases.

Published
2025
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2. Extreme semilinear copulas

Author

Durante, Fabrizio, Fernández-Sánchez, Juan, and Úbeda-Flores, Manuel

Subjects
Mathematics - Probability
Abstract

We study the extreme points (in the Krein-Milman sense) of the class of semilinear copulas and provide their characterization. Related results into the more general setting of conjunctive aggregation functions (i.e, semi--copulas and quasi--copulas) are also presented.

Published
2025
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3. Results of a Randomized Wait-List Controlled Trial of CAYA: A Nurse Case Management HIV Prevention Intervention for Youth Experiencing Homelessness.

Author

Maria, Diane, Nyamathi, Adeline, Lightfoot, Marguerita, Paul, Mary, Quadri, Yasmeen, Padhye, Nikhil, Businelle, Michael, Fernandez-Sanchez, Higinio, and Jones, Jennifer

Subjects
Condom use, HIV Prevention, PrEP, Substance use, Youth Homelessness, nPEP, Humans, HIV Infections, Male, Female, Adolescent, Case Management, Young Adult, Adult, Ill-Housed Persons, Homeless Youth, Condoms, Waiting Lists, Pre-Exposure Prophylaxis
Abstract

Youth experiencing homelessness (YEH) face challenges that increase their susceptibility to HIV/STIs. Nurse case management is effective in managing the complex needs of populations experiencing homelessness and reducing HIV risk. A randomized wait-list control study conducted between September 2019 to May 2023 evaluated the CAYA Come As You Are intervention. This nurse-led HIV prevention for YEH aged 16-25 years focused on the uptake of HIV prevention methods: pre- and post-HIV exposure prophylaxis (PrEP, nPEP), HIV/STI testing and treatment, sober sex, and condom use. Secondarily, we examined intervention impact on housing stability. Descriptive statistics were calculated by study arm. Multiple imputation (m = 10) was used for missing values and intervention effects were estimated from Bayesian multilevel models with noninformative priors. Participants (N = 450) were 21.1 years old on average, 62% Black, 11% Hispanic, 11% White, and 10% other race and reported being homeless for an average of 3 years. An intervention effect was found for PrEP use, which showed a larger increase from baseline to first follow-up (OR = 3.27; 95% Cr.I.: 1.13 to 10.14). No intervention impact was found for nPEP use, HIV and STI cases, sober sex, or condom use. Sheltering arrangements improved from baseline to the first follow-up in both groups with increase in shelter stability (OR = 3.85; 95% Cr.I.: 1.61 to 10.30) and decreased shelter transiency (OR = 0.29; 95% Cr.I.: 0.14 to 0.60). This study demonstrates that a personalized, nurse-led HIV prevention approach increased uptake of some but not all HIV prevention strategies among YEH. CLINICAL TRIAL REGISTRATION NUMBER: NCT03910218.

Published
2025

4. Alpha Entropy Search for New Information-based Bayesian Optimization

Author

Fernández-Sánchez, Daniel, Garrido-Merchán, Eduardo C., and Hernández-Lobato, Daniel

Subjects
Statistics - Machine Learning, Computer Science - Machine Learning
Abstract

Bayesian optimization (BO) methods based on information theory have obtained state-of-the-art results in several tasks. These techniques heavily rely on the Kullback-Leibler (KL) divergence to compute the acquisition function. In this work, we introduce a novel information-based class of acquisition functions for BO called Alpha Entropy Search (AES). AES is based on the {\alpha}-divergence, that generalizes the KL divergence. Iteratively, AES selects the next evaluation point as the one whose associated target value has the highest level of the dependency with respect to the location and associated value of the global maximum of the optimization problem. Dependency is measured in terms of the {\alpha}-divergence, as an alternative to the KL divergence. Intuitively, this favors the evaluation of the objective function at the most informative points about the global maximum. The {\alpha}-divergence has a free parameter {\alpha}, which determines the behavior of the divergence, trading-off evaluating differences between distributions at a single mode, and evaluating differences globally. Therefore, different values of {\alpha} result in different acquisition functions. AES acquisition lacks a closed-form expression. However, we propose an efficient and accurate approximation using a truncated Gaussian distribution. In practice, the value of {\alpha} can be chosen by the practitioner, but here we suggest to use a combination of acquisition functions obtained by simultaneously considering a range of values of {\alpha}. We provide an implementation of AES in BOTorch and we evaluate its performance in both synthetic, benchmark and real-world experiments involving the tuning of the hyper-parameters of a deep neural network. These experiments show that the performance of AES is competitive with respect to other information-based acquisition functions such as JES, MES or PES., Comment: 31 pages, 12 figures, 3 tables, Journal KBS

Published
2024

6. Algebrability and Riemann integrability of the composite function

Author

D'Aniello, E., Fernández-Sánchez, J., Maiuriello, M., and Sepúlveda, J. B. Seoane

Subjects
Mathematics - Functional Analysis
Abstract

In this note we show that there exist a $2^\mathfrak{c}$-generated free algebra $\mathcal{S} \subset \mathbb{R}^\mathbb{R}$ of Riemann integrable functions and a free algebra $\mathcal{C} \subset \mathbb{R}^{[0,1]}$ of continuous functions, having $\mathfrak{c}$-generators, such that $r \circ c$ is not Riemann integrable for any $r \in \mathcal{S}$ and $c \in \mathcal{C}$. This result is the best possible one in terms of lineability within these families of functions and, at the same time, an improvement of a precious result (\cite[Theorem 2.7]{A}). In order to achieve our results we shall employ set theoretical tools such as the Fichtenholz-Kantorovich-Hausdorff theorem, Cantor-Smith-Volterra--type sets, and classical real analysis techniques.

Published
2024

7. Phylogenetic invariants: straightforward from the general Markov to equivariant models

Author

Casanellas, Marta and Fernández-Sánchez, Jesús

Subjects
Quantitative Biology - Populations and Evolution, Mathematics - Algebraic Geometry, 14J99, 92D15, 05C85, 62R01
Abstract

In the last decade, some algebraic tools have been successfully applied to phylogenetic reconstruction. These tools are mainly based on the knowledge of equations describing algebraic varieties associated to phylogenetic trees evolving under Markov processes of molecular substitution, the so called phylogenetic invariants. Although the theory involved allows to explicitly obtain these equations for all equivariant models (which include some of the most popular nucleotide substitution models), practical uses of these algebraic tools have been restricted to the case of the general Markov model. Arguably, one of the reasons for this restriction is that knowledge of linear representation theory is required before making these equations explicit. With the aim of enlarging the practical uses of algebraic phylogenetics, in this paper we prove that phylogenetic invariants for trees evolving under equivariant models can be derived from phylogenetic invariants for the general Markov model, without the need of representation theory. Our main result states that the algebraic variety corresponding to a phylogenetic tree evolving under an equivariant model is an irreducible component of the variety corresponding to the same tree under the general Markov model cut with the linear space defined by the model. We also prove that, for any equivariant model, those phylogenetic invariants that are relevant for practical uses (e.g. tree reconstruction) can be simply deduced from a single rank constraint on the matrices obtained by flattening the joint distribution at the leaves of the tree. This condition can be easily tested from singular values of the matrices and extends our results from trees to phylogenetic networks., Comment: 30 pages, 4 figures

Published
2023

9. Software Startups -- A Research Agenda

Author

Unterkalmsteiner, Michael, Abrahamsson, Pekka, Wang, Xiaofeng, Nguyen-Duc, Anh, Shah, Syed M. Ali, Bajwa, Sohaib Shahid, Baltes, Guido H., Conboy, Kieran, Cullina, Eoin, Dennehy, Denis, Edison, Henry, Fernández-Sánchez, Carlos, Garbajosa, Juan, Gorschek, Tony, Klotins, Eriks, Hokkanen, Laura, Kon, Fabio, Lunesu, Ilaria, Marchesi, Michele, Morgan, Lorraine, Oivo, Markku, Selig, Christoph, Seppänen, Pertti, Sweetman, Roger, Tyrväinen, Pasi, Ungerer, Christina, and Yagüe, Agustín

Subjects
Computer Science - Software Engineering
Abstract

Software startup companies develop innovative, software-intensive products within limited time frames and with few resources, searching for sustainable and scalable business models. Software startups are quite distinct from traditional mature software companies, but also from micro-, small-, and medium-sized enterprises, introducing new challenges relevant for software engineering research. This paper's research agenda focuses on software engineering in startups, identifying, in particular, 70+ research questions in the areas of supporting startup engineering activities, startup evolution models and patterns, ecosystems and innovation hubs, human aspects in software startups, applying startup concepts in non-startup environments, and methodologies and theories for startup research. We connect and motivate this research agenda with past studies in software startup research, while pointing out possible future directions. While all authors of this research agenda have their main background in Software Engineering or Computer Science, their interest in software startups broadens the perspective to the challenges, but also to the opportunities that emerge from multi-disciplinary research. Our audience is therefore primarily software engineering researchers, even though we aim at stimulating collaborations and research that crosses disciplinary boundaries. We believe that with this research agenda we cover a wide spectrum of the software startup industry current needs.

Published
2023
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12. A link between Kendall's tau, the length measure and the surface of bivariate copulas, and a consequence to copulas with self-similar support

Author

Fernández-Sánchez, Juan and Trutschnig, Wolfgang

Subjects
Mathematics - Statistics Theory
Abstract

Working with shuffles we establish a close link between Kendall's tau, the so-called length measure, and the surface area of bivariate copulas and derive some consequences. While it is well-known that Spearman's rho of a bivariate copula A is a rescaled version of the volume of the area under the graph of A, in this contribution we show that the other famous concordance measure, Kendall's tau, allows for a simple geometric interpretation as well - it is inextricably linked to the surface area of A., Comment: 12 pages, 3 figures

Published
2023

13. A succinct characterization of period annuli in planar piecewise linear differential systems with a straight line of nonsmoothness

Author

Carmona, Victoriano, Fernández-Sánchez, Fernando, and Novaes, Douglas D.

Subjects
Mathematics - Dynamical Systems, 34A36, 34C25, 37C27
Abstract

We close the problem of the existence of period annuli in planar piecewise linear differential systems with a straight line of nonsmoothness. In fact, a characterization for the existence of such objects is provided by means of a few basic operations on the parameters.

Published
2022
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14. Uniform upper bound for the number of limit cycles of planar piecewise linear differential systems with two zones separated by a straight line

Author

Carmona, Victoriano, Fernández-Sánchez, Fernando, and Novaes, Douglas D.

Subjects
Mathematics - Dynamical Systems, 34A26, 34A36, 34C25
Abstract

The existence of a uniform upper bound for the maximum number of limit cycles of planar piecewise linear differential systems with two zones separated by a straight line has been subject of interest of hundreds of papers. After more than 30 years of investigation since Lum-Chua's work, it has remained an open question whether this uniform upper bound exists or not. Here, we give a positive answer for this question by establishing the existence of a natural number $L^*\leq 8$ for which any planar piecewise linear differential system with two zones separated by a straight line has no more than $L^*$ limit cycles. The proof is obtained by combining a newly developed integral characterization of Poincar\'{e} half-maps for linear differential systems with an extension of Khovanski\u{\i}'s theory for investigating the number of intersection points between smooth curves and a particular kind of orbits of vector fields.

Published
2022
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15. A Contemporary Picture of Coagulase-Negative Staphylococcal Endocarditis: A Nationwide GAMES Cohort Study

Author

Fernández Sánchez, Fernando, García de Lomas, José M., Rosas, Gabriel, de la Torre Lima, Javier, Bereciartua, Elena, Blanco Vidal, María José, Blanco, Roberto, Boado, María Victoria, Lázaro, Marta Campaña, Crespo, Alejandro, Carrión, Laura Guio, Martínez de Lagos, Mikel Del Álamo, Ugarte, Gorane Euba, Goikoetxea, Ane Josune, Hierro, Marta Ibarrola, Iruretagoyena, José Ramón, Zuazabal, Josu Irurzun, López-Soria, Leire, Montejo, Miguel, Nieto, Javier, Rodrigo, David, Rodríguez, Regino, Vitoria, Yolanda, Voces, Roberto, García López, M<ce:sup loc='post">a</ce:sup> Victoria, Georgieva, Radka Ivanova, Ojeda, Guillermo, Bailón, Isabel Rodríguez, Morales, Josefa Ruiz, Rodríguez, Ignacio Álvarez, Galparsoro, Harkaitz Azkune, Boronat, Elisa Berritu, Odriozola, M<ce:sup loc='post">a</ce:sup> Jesús Bustinduy, Martín, Cristina del Bosque, Echeverría, Tomás, Yarza, Alberto Eizaguirre, Fuentes, Ana, Goenaga, Miguel Ángel, del Río, Muskilda Goyeneche, Bauza, Ángela Granda, Iribarren, José Antonio, Urkola, Xabier Kortajarena, Pérez-Moreiras López, José Ignacio, Jiménez, Ainhoa Rengel, Reviejo, Karlos, Berbejillo, Alberto Sáez, Haza, Elou Sánchez, Alda, Rosa Sebastián, Ruiz, Itziar Solla, Ugartemendia, Irati Unamuno, Anza, Diego Vicente, Villanueva Benito, Iñaki, Arrieta, Mar Zabalo, Carrasco, Rafael, Climent, Vicente, Llamas, Patricio, Merino, Esperanza, Plazas, Joaquín, Reus, Sergio, Alonso, Alicia, Bouzas, Alberto, Castelo, Brais, Cuenca, José, Gutiérrez, Laura, Ramos, Lucía, Mayo, María Rodríguez, Serrano, Joaquín Manuel, Regueiro, Dolores Sousa, Martínez Marcos, Francisco Javier, M, del Mar Alonso, Castro, Beatriz, Melian, Teresa Delgado, Sarabia, Javier Fernández, Rosado, Dácil García, González González, Julia, Lacalzada, Juan, de la Peña, Lissete Lorenzo, Ramírez, Alina Pérez, Arrondo, Pablo Prada, Moreno, Fermín Rodríguez, Ciezar, Antonio Plata, Reguera Iglesias, José M<ce:sup loc='post">a</ce:sup>, Asensi Álvarez, Víctor, Álvarez Cabo, Rubén, Caminal, Luis, de la Hera, Jesús, García, Laura, Iglesias Fraile, Lisardo, León Arguero, Víctor, Bajo, Pilar Mencia, Morales Pérez, Carlos, Rodríguez García, Raquel, Rodríguez Esteban, M<ce:sup loc='post">a</ce:sup> Ángeles, Silva, Jacobo, Almela, Manuel, Ambrosioni, Juan, Azqueta, Manuel, Brunet, Mercè, Bodro, Marta, Cartañá, Ramón, Cuervo, Guillermo, Falces, Carlos, Fernández-Pittol, Mariana J., Fita, Guillermina, Fuster, David, de la Mària, Cristina García, García-Pares, Delia, Hernández-Meneses, Marta, Pérez, Jaume Llopis, Marco, Francesc, Miró, José M., Moreno, Asunción, Nicolás, David, Ninot, Salvador, Quintana, Eduardo, Paré, Carlos, Pereda, Daniel, Pericás, Juan M., Pomar, José L., Ramírez, José, Roque, Mercè, Rovira, Irene, Sandoval, Elena, Sitges, Marta, Soy, Dolors, Téllez, Adrián, Tolosana, José M., Vidal, Bárbara, Vila, Jordi, Adán, Iván, Alonso, David, Alonso, Juan Carlos, Álvarez-Uría, Ana, Bermejo, Javier, Bouza, Emilio, Caballero, Gregorio Cuerpo, Montero, Antonia Delgado, Estévez, Agustín, Fortuny Ribas, Ramón, Gargallo, Esther, García Leoni, M<ce:sup loc='post">a</ce:sup> Eugenia, González Mansilla, Ana, González Moraga, Francisco Javier, González Ramallo, Víctor, Kestler Hernández, Martha, Hualde, Amaia Mari, Machado, Marina, Marín, Mercedes, Martínez-Sellés, Manuel, Melero, Rosa, Muñoz, Patricia, Monzón, Diego, Olmedo, María, Pedraz, Álvaro, Pinilla, Blanca, Pinto, Ángel, Rincón, Cristina, Rodríguez-Abella, Hugo, Rodríguez-Créixems, Marta, Sánchez-Pérez, Eduardo, Segado, Antonio, Toledo, Neera, Valerio, Maricela, Vázquez, Pilar, Moreno, Eduardo Verde, de la Villa, Sofía, Antorrena, Isabel, Loeches, Belén, Moreno, Mar, Ramírez, Ulises, Bastón, Verónica Rial, Romero, María, Rosillo, Sandra, Agüero Balbín, Jesús, Amado Fernández, Cristina, Armiñanzas Castillo, Carlos, Arnaiz de las Revillas, Francisco, Cobo Belaustegui, Manuel, Carmen Fariñas, María, Fariñas-Álvarez, Concepción, Fernández Sampedro, Marta, García, Iván, Garrido, Raquel, González Rico, Claudia, Gutiérrez-Fernández, Laura, Gutiérrez-Cuadra, Manuel, Gutiérrez Díez, José, Pajarón, Marcos, Parra, José Antonio, Alonso, Noelia Ruiz, Teira, Ramón, Zarauza, Jesús, Parra, Jorge Calderón, Cobo, Marta, Domínguez, Fernando, García Pavía, Pablo, Fernández Cruz, Ana, López Azor, Juan Carlos, Ramos-Martínez, Antonio, Romero, Isabel Sánchez, Centella, Tomasa, Cobo, Javier, Gioia, Francesca, Hermida, José Manuel, Moya, José Luis, Martín-Dávila, Pilar, Navas, Enrique, Oliva, Enrique, del Río, Alejandro, Rodríguez-Roda Stuart, Jorge, Ruiz, Soledad, Hidalgo Tenorio, Carmen, Sequera, Sergio, Almendro Delia, Manuel, Araji, Omar, Barquero, José Miguel, Calvo Jambrina, Román, de Cueto, Marina, Gálvez Acebal, Juan, Méndez, Irene, Morales, Isabel, López-Cortés, Luis Eduardo, de Alarcón, Arístides, Gutiérrez-Carretero, Encarnación, Lepe, José Antonio, López-Haldón, José, Luque-Márquez, Rafael, Marín, Guillermo, Ortiz-Carrellán, Antonio, Poyato Borrego, Manuel, Sánchez-Domínguez, Eladio, Alonso, Luis Javier, Azcárate, Pedro, Azcona Gutiérrez, José Manuel, Blanco, José Ramón, Armas, Estíbaliz Corral, García-Álvarez, Lara, Oteo, José Antonio, Barros Membrilla, Antonio, Ginel Iglesias, Antonino, Grillo, Sara, Petracca, Rubén Leta, López-Contreras, Joaquín, Rivera Martínez, María Alba, Álvarez, M., Fernández, A.L., Martínez, Amparo, Prieto, A., Regueiro, Benito, Tijeira, E., Vega, Marino, Aguirre Quiñonero, Amaia, Miñambres, Ángela Alonso, Gainzarain Arana, Juan Carlos, de Alaiza Ortega, Sara González, Morán Rodríguez, Miguel Ángel, Moreno Rodríguez, Anai, Ortiz de Zárate, Zuriñe, Zapirain, José Joaquín Portu, de Adana Arroniz, Ester Sáez, Sorto Sánchez, Daisy Carolina, Antonio, Sánchez-Porto, Alejandro, Úbeda Iglesias, Albert, Laura, Cánovas, Sergio, Vázquez, Elisa García, Torres, Alicia Hernández, Blázquez, Ana, de la Morena Valenzuela, Gonzalo, de Gea, José H., Martínez Toldos, M<ce:sup loc='post">a</ce:sup> Carmen, Escudero, Encarnación Moral, Oliva, M<ce:sup loc='post">a</ce:sup> José, Ortín, Alejandro, Pérez Andreu, Joaquín, Piloto, Avchel Roura, Saura, Daniel, Alonso, Ángel, Aramburu, Javier, Calvo, Felicitas Elena, Tarabini-Castellani, Paola, Heredero Gálvez, Eva, Bellido, Carolina Maicas, Largo Pau, José, Sepúlveda, M<ce:sup loc='post">a</ce:sup> Antonia, Toledano Sierra, Pilar, Zafar Iqbal-Mirza, Sadaf, Alcolea, Eva Cascales, Yañez, Ivan Keituqwa, Navarro Martínez, Julián, Peláez Ballesta, Ana, Moreno Escobar, Eduardo, Peña Monje, Alejandro, Sánchez Cabrera, Valme, Vinuesa García, David, Arrizabalaga Asenjo, María, Cifuentes Luna, Carmen, Núñez Morcillo, Juana, Pérez Seco, M<ce:sup loc='post">a</ce:sup> Cruz, Villoslada Gelabert, Aroa, Aured Guallar, Carmen, Abad, Nuria Fernández, Mangas, Pilar García, Matamala Adell, Marta, Palacián Ruiz, M<ce:sup loc='post">a</ce:sup> Pilar, Porres, Juan Carlos, Vidal, Begoña Alcaraz, Del Amor Espín, María Jesús, Buendía, Francisco, Sánchez, Roberto Jiménez, Mármol, Rosario, Martínez, Francisco, Meseguer, Antonio, Pérez, Beatriz, Risco, Leticia, Saura, Zoser, Silva, Vanina, Villmarín, M<ce:sup loc='post">a</ce:sup> Belén, Ribas Blanco, M<ce:sup loc='post">a</ce:sup> Ángels, de Gopegui Bordes, Enrique Ruiz, Vidal Bonet, Laura, Vives Borràs, Miquel, Bellón Munera, M<ce:sup loc='post">a</ce:sup> Carmen, Escribano Garaizabal, Elena, Tercero Martínez, Antonia, Segura Luque, Juan Carlos, Badía, Cristina, Boix-Palop, Lucía, Xercavins, Mariona, Ibars, Sónia, Fernández- Paniagua, Estefanía Águila, Bosch, Xerach, Gilarranz Luengo, Raúl, Gómez Nebreda, Eloy, Herrera, Ibalia Horcajada, Menduiña Gallego, Irene, Mohamed Ramírez, Karim, Pulido, Imanol, Nelson, Verónica Quevedo, Urso, Stefano, Santiago, Héctor Marrero, de Miguel Martínez, Isabel, Álamo, Elena Pisos, San Román Sánchez, Daniel, Pérez, Jorge Boan, Aguilar Blanco, Eva M., González, Mercedes Catalán, Corres Peiretti, María Angélica, Esteve, Andrea Eixerés, Pérez, Laura Domínguez, de Cossío Tejido, Santiago, Galván Román, Francisco, García Robles, José Antonio, López-Medrano, Francisco, López Gude, M<ce:sup loc='post">a</ce:sup> Jesús, Orellana Miguel, M<ce:sup loc='post">a</ce:sup> Ángeles, Pilkington, Patrick, Ostalaza, Yolanda Revilla, Morales, Juan Ruiz, Solís, Sebastián Ruiz, Collado, Ana Sabín, Sánchez Fernández, Marcos, Rallo, Javier Solera, Martín, Jorge Solís, Escrihuela-Vidal, Francesc, Carratalà, Jordi, Grau, Imma, Ardanuy, Carmen, Berbel, Dámaris, Alegre, Oriol, Mañas Jiménez, María Pilar, Notta Gonzalez, Paula Cecilia, Sbraga, Fabrizio, Blasco, Arnau, Gracia Sánchez, Laura, Sánchez-Rodríguez, Iván, Aldamiz, Gonzalo, Álvarez, Beatriz, Bernal Palacios, Marina, Cabello Úbeda, Alfonso, Fernández Roblas, Ricardo, Hernández, Rafael, Hortigüela Martín, Victoria Andrea, Kallmeyer, Andrea, Kancev, Cristina Landaeta, Martín, Marta, Ruiz, Miguel Morante, Navas Lobato, Miguel Ángel, Pello, Ana María, Prieto, Laura, Mallebrera, Marta Tomás, Varela, Laura, de la Peña Triguero, Mireia, Cerón, Ruth Esther Figueroa, Gómez, Lara Ruiz, Ble, Mireia, Horcajada Gallego, Juan Pablo, Ginel, Antonio José, López, Inmaculada, Mas, Alexandra, Mestres, Antoni, Molina, Lluís, Serrat, Ramón, Ribas, Núria, Sánchez, Francisca, Silverio, Ana, Suárez, Marina, Sorlí, Luisa, Recasens, Lluís, Taurón, Manuel, Fernández Regueras, María, Mantecón Vallejo, María Ángeles, Pérez Rivera, José Ángel, Mata, Nuria Sánchez, Calvo Cano, Antonia, Fajardo Olivares, Miguel, Millán Núñez, María Victoria, Muñoz Sanz, Agustín, Palom-Grau, Clara, Marín Arriaza, Mercedes, González-Ramallo, Víctor, Poyato-Borrego, Manuel, Rodríguez-García, Raquel, Rodríguez-Esteban, M. Ángeles, Fariñas, M. Carmen, González-Rico, Claudia, Ojeda-Burgos, Guillermo, Goikoetxea-Agirre, Ane Josune, Calderón-Parra, Jorge, López-Azor, Juan Carlos, García-Vázquez, Elisa, Quintana, Eduard, García de la Mària, Cristina, and Llopis, Jaume

Published
2025
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17. Antibiotic‐associated neutropenia is marked by the depletion of intestinal Lachnospiraceae and associated metabolites in pediatric patients

Author

Josaura Fernandez‐Sanchez, Rachel Rodgers, Arushana A. Maknojia, Nusrat Shaikh, Hannah Yan, Marlyd E. Mejia, Hope Hendricks, Robert R. Jenq, Pavan Reddy, Ritu Banerjee, Jeremy M. Schraw, Megan T. Baldridge, and Katherine Y. King

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Abstract Prolonged antibiotic exposure causes dangerous hematologic side effects, including neutropenia, in up to 34% of patients. Murine studies established a link between the intestinal microbiota and hematopoiesis. To identify factors that predispose to neutropenia in pediatric patients, we evaluated changes in microbiota‐derived metabolites and intestinal microbiota composition after prolonged courses of antibiotics. In this multi‐center study, patients with infections requiring anticipated antibiotic treatment of two or more weeks were enrolled. Stool samples were obtained at the start and completion of antibiotics or at neutropenia onset (prospective arm). Some patients were enrolled in a retrospective arm in which a stool sample was collected at the time of neutropenia during antibiotic therapy and 2–4 weeks after completion of antibiotics with recovery of blood counts. We identified 10 patients who developed neutropenia on antibiotics and 29 controls matched for age, sex, race, and ethnicity. Clinical data demonstrated no association between neutropenia and the type of infection or antibiotic used; however, patients with neutropenia were admitted to the intensive care unit more often and received longer courses of antibiotics. Reduced intestinal microbiome richness and, specifically, decreased abundance of Lachnospiraceae family members correlated with neutropenia. Untargeted stool metabolomic profiling revealed several metabolites that were depleted exclusively in patients with neutropenia, including members of the urea cycle pathway, pyrimidine metabolism, and fatty acid metabolism that are known to be produced by Lachnospiraceae. Our study shows a relationship between intestinal microbiota disruption and abnormal hematopoiesis and identifies taxa and metabolites likely to contribute to microbiota‐sustained hematopoiesis.

Published
2024
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18. Uniqueness and stability of limit cycles in planar piecewise linear differential systems without sliding region

Author

Carmona, Victoriano, Fernández-Sánchez, Fernando, and Novaes, Douglas D.

Subjects
Mathematics - Dynamical Systems
Abstract

In this paper, we consider the family of planar piecewise linear differential systems with two zones separated by a straight line without sliding regions, that is, differential systems whose flow transversally crosses the switching line except for at most one point. In the research literature, many papers deal with the problem of determining the maximum number of limit cycles that these differential systems can have. This problem has been usually approached via large case-by-case analyses which distinguish the many different possibilities for the spectra of the matrices of the differential systems. Here, by using a novel integral characterization of Poincar\'e half-maps, we prove, without unnecessary distinctions of matrix spectra, that the optimal uniform upper bound for the number of limit cycles of these differential systems is one. In addition, it is proven that this limit cycle, if it exists, is hyperbolic and its stability is determined by a simple condition in terms of the parameters of the system. As a byproduct of our analysis, a condition for the existence of the limit cycle is also derived., Comment: To appear in Communications in Nonlinear Science and Numerical Simulation

Published
2022
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19. Some properties of differentiable p-adic functions

Author

Fernández-Sánchez, Juan, Maghsoudi, Saeid, Rodríguez-Vidanes, Daniel L., and Seoane-Sepúlveda, Juan B.

Subjects
Mathematics - Functional Analysis
Abstract

In this paper, using the tools from the lineability theory, we distinguish certain subsets of $p$-adic differentiable functions. Specifically, we show that the following sets of functions are large enough to contain an infinite dimensional algebraic structure: (i) continuously differentiable but not strictly differentiable functions, (ii) strictly differentiable functions of order $r$ but not strictly differentiable of order $r+1$, (iii) strictly differentiable functions with zero derivative that are not Lipschitzian of any order $\alpha >1$, (iv) differentiable functions with unbounded derivative, and (v) continuous functions that are differentiable on a full set with respect to the Haar measure but not differentiable on its complement having cardinality the continuum.

Published
2022

20. Designing weights for quartet-based methods when data is heterogeneous across lineages

Author

Casanellas, Marta, Fernández-Sánchez, Jesús, Garrote-López, Marina, and Sabaté-Vidales, Marc

Subjects
Quantitative Biology - Populations and Evolution, 92D15
Abstract

Homogeneity across lineages is a common assumption in phylogenetics according to which nucleotide substitution rates remain constant in time and do not depend on lineages. This is a simplifying hypothesis which is often adopted to make the process of sequence evolution more tractable. However, its validity has been explored and put into question in several papers. On the other hand, dealing successfully with the general case (heterogeneity across lineages) is one of the key features of phylogenetic reconstruction methods based on algebraic tools. The goal of this paper is twofold. First, we present a new weighting system for quartets (ASAQ) based on algebraic and semi-algebraic tools, thus specially indicated to deal with data evolving under heterogeneus rates. This method combines the weights two previous methods by means of a test based on the positivity of the branch length estimated with the paralinear distance. ASAQ is statistically consistent when applied to GM data, considers rate and base composition heterogeneity among lineages and does not assume stationarity nor time-reversibility. Second, we test and compare the performance of several quartet-based methods for phylogenetic tree reconstruction (namely, Quartet Puzzling, Weight Optimization and Wilson's method) in combination with ASAQ weights and other weights based on algebraic and semi-algebraic methods or on the paralinear distance. These tests are applied to both simulated and real data and support Weight Optimization with ASAQ weights as a reliable and successful reconstruction method., Comment: Main article: 25 pages, 6 figures, 4 tables; 1 appendix: 22 pages, 11 figures, 7 yables

Published
2022

21. Intravenous glibenclamide for cerebral oedema after large hemispheric stroke (CHARM): a phase 3, double-blind, placebo-controlled, randomised trial

Author

Abraham, Michael, Acosta, Indrani, Agostoni, Elio Clemente, Aguera Morales, Eduardo, Akaike, Yuji, Ale Bark, Samir, Alexandrov, Andrei, Altschul, Dorothea, Arenillas Lara, Juan Francisco, Arias Rivas, Susana, Arnold, Marcel, Asimos, Andrew, Bar, Michal, Barlinn, Kristian, Beccia, Mario, Benesch, Curtis, Bereczki, Daniel, Berk, Julie, Berkeley, Jennifer, Berrouschot, Joerg, Bettermann, Kerstin, Bevers, Matthew, Bösel, Julian, Bogdanov, Enver, Bonato, Sara, Bornstein, Natan, Boutwell, Christine, Bowling, Susana, Brown, Helen, Bruno, Askiel, Burgin, William, Bustamante, Rafael, Cabral Moro, Carla Heloísa, Cao, Wenfeng, Carandang, Raphael, Cardona Portela, Pedro, Castro, Pedro, Cativo, Maria, Cereda, Carlo, Cerejo, Russell, Chang, Chiung-Chih, Cheng, Roger, Chin, Masaki, Ching, Marilou, Christensen, Hanne, Chung, Lee, Clark, Jonie, Clark, Wayne, Cloud, Geoffrey, Cogez, Julien, Comi, Giancarlo, Cordato, Dennis, Coull, Bruce, Cronin, Carolyn, Csanyi, Attila, Cullis, Paul, Czeisler, Barry, Dangayach, Neha, Datta, Mohit, Debouverie, Marc, Demchuk, Andrew, Denier, Christian, Desfontaines, Philippe, Devlin, Thomas, Dhar, Rajat, Diomedi, Marina, Dioszeghy, Peter, Diringer, Michael, Dixit, Anand, Dong, Qiang, Eichel, Roni, Elliott, Jamie, Fan, Dongsheng, Fernandez Sanchez, Victoria Eugenia, Ferro, José Manuel, Finocchi, Cinzia, Foreman, Brandon, Fortea Cabo, Gerardo, Freire Goncalves, Antonio, Fukuyama, Kozo, Gamero Garcia, Miguel Angel, Garcia Esperon, Carlos, Geng, Deqin, Ghoshal, Shivani, Gomes, Joao, Gordon, Errol, Guillon, Benoit, Hagihara, Yasushi, Hallevi, Hen, Halse, Omid, Han, Moon-Ku, Hargis, Mitch, Harnof, Sagi, Harsany, Michal, Hasegawa, Yasuhiro, Hassan, Ameer, Hayasaka, Michihiro, He, Jincai, Hemelsoet, Dimitri, Henon, Hilde, Herzig, Roman, Hill, Michael, Hinduja, Archana, Hirano, Teruyuki, Horev, Anat, Howell, Bradley, Hu, Xingyue, Huang, David, Hwang, Yangha, Ifergane, Gal, Isayev, Yevgeniy, Ito, Yasuhiro, Iversen, Helle, Jatuzis, Dalius, Jeng, Jiann-Shing, Jeon, Sang-Beom, Jeong, Jin-Heon, Ji, Qiuhong, Kahles, Timo, Kallmuenzer, Bernd, Kaneko, Chikako, Kanzawa, Takao, Kasner, Scott, Kawabata, Masayuki, Kelly, Adam, Kerrigan, Deborah, Keshary, Sanjeev, Khanna, Anna, Kidjemet-Piskac, Spomenka, Kidwell, Chelsea, Kim, Minjee, Kimura, Kazumi, Kimura, Naoto, Kin, Shigenari, Kirmani, Jawad, Kitazawa, Kazuo, Kleinig, Timothy, Koehrmann, Martin, Koga, Masatoshi, Kollmar, Rainer, Konno, Hiromu, Krause, Martin, Kuga, Yoshihiro, Kullman, Dimitri, Kurka, Natalia, Lago Martin, Aida, Latorre, Julius (Gene), LeDoux, David, Leal Loureiro, Jose, Lebedeva, Anna, Lee, Tsong-Hai, Leker, Ronen, Lemmens, Robin, Li, Yansheng, Lioutas, Vasileious-Arsenios, Liu, Chunfeng, Liu, Liping, Liu, Wei, Liu, Yaling, Longoni, Marco, Lopez, George, Lord, Aaron, Lu, Zuneng, Machida, Akira, Magoni, Mauro, Malik, Maheen, Marcheselli, Simona, Marques Pontes Neto, Octávio, Martin, Jerry, Martino, Stephen, Martins Maia Carvalho, Fernanda, Masjuan Vallejo, Jaime, Matijosaitis, Vaidas, Mayer, Stephan, McGrade, Harold, Mehta, Sanal, Melmed, Kara, Melnikova, Elena, Messe, Steven, Meyer, Brett, Miller, Chad, Minnerup, Jens, Mittal, Shilpi, Molina Cateriano, Carlos, Moniche Alvarez, Francisco, Moroi, Junta, Moulin, Thierry, Muir, Keith, Murase, Satoru, Murialdo, Alessandra, Muscat, Paul, Nagy, Ferenc, Nakagawa, Kazuma, Nakagawa, Koshi, Nakano, Shin, Naval, Neeraj, Nencini, Patrizia, Ng, Kwan, Niesen, Wolf-Dirk, Nomura, Sadahiro, Olds, Karin, Olga, Samoshkina, Ota, Shinzo, Ouriques Martins, Sheila Cristina, Ovary, Csaba, Panczel, Gyula, Peretz, Shlomi, Perry, Richard, Petersen, Nils, Phan, Thanh, Pinho e Melo, Teresa, Poisson, Sharon, Poljakovic, Zdravka, Pulido, Angel, Radai, Ferenc, Ramiro, Joanna Isabelle I., Ramos-Estebanez, Ciro, Ratcliff, Jonathan, Renati, Swetha, Richard, Sébastien, Rincon, Fred, Rippee, Michael, Rocha, Marcelo, Rodrigues, Miguel, Rodriguez Campello, Ana, Roh, David, Roje Bedekovic, Marina, Roquer Gonzalez, Jaime, Roriz Cruz, Matheus, Roriz, José Mário, Roshkovskaya, Ludmila, Roveri, Luisa, Ruano, Luis, Rubio Borrego, Francisco, Ruuskanen, Jori, Rybinnik, Igor, Sabet, Arman, Sakai, Nobuyuki, Sampaio Silva, Gisele, Santo, Gustavo, Sarwal, Aarti, Sato, Kenichi, Sato, Kota, Sattin, Justin, Schaefer, Jan-Hendrik, Schneider, Hauke, Serena Leal, Joaquin, Shah, Ruchir, Shah, Shreyansh, Sharma, Kartavya, Shepherd, Starane, Shi, Fudong, Shimoe, Yutaka, Shuaib, Ashfaq, Sibon, Igor, Silliman, Scott, Skorna, Miroslav, Snider, Samuel, Soda, Hassan, Sprigg, Nikola, Stetkarova, Ivana, Strbian, Daniel, Streib, Christopher, Stretz, Hanns Christoph, Sugimori, Hiroshi, Sundararajan, Sophia, Sung, Pi-Shan, Sztriha, Laszlo, Takahashi, Shinichi, Takizawa, Katsumi, Takizawa, Shunya, Tang, Sung-Chun, Tassi, Rosanna, Tayal, Ashis, Tedim Cruz, Vitor, Telman, Gregory, Temes, Richard, Terry, John, Tian, Xiangyang, Timchenko, Ludmila, Timsit, Serge, Tirschwell, David, Tokunaga, Koji, Tomek, Ales, Toni, Danilo, Torbey, Michel, Ueda, Masayuki, Uriel, Eitan, Valverde Moyano, Roberto, Vandermeeren, Yves, Vannier, Stéphane, Vargas, Alejandro, Vecsei, Laszlo, Veltkamp, Roland, Venkatasubramanian, Chitra, Viana Baptista, Miguel, Vilionskis, Aleksandras, Vohanka, Stanislav, Voznyuk, Igor, Wang, Furong, Wang, Guoping, Wang, Ning, Warburton, Elizabeth, Waters, Michael, Wen, Guoqiang, Wendell, Linda, Werring, David, Wienecke, Troels, Wijeratne, Tissa, Wilson, Laura, Witt, John, Wu, Jin, Xiong, Yingqiong, Xu, En, Xu, Jindong, Yamano, Yoshihisa, Yan, Fuling, Yang, Yi, Yi, Fei, Youn, Teddy, Zachariah, George, Zafar, Sahar, Zaidi, Syed, Zammit, Christopher, Zeng, Jinsheng, Zhang, Guilian, Zhang, Meng, Zini, Andrea, Zinke, Jan, Zurasky, John, Sheth, Kevin N, Albers, Gregory W, Saver, Jeffrey L, Campbell, Bruce C V, Molyneaux, Bradley J, Hinson, H E, Cordonnier, Charlotte, Steiner, Thorsten, Toyoda, Kazunori, Wintermark, Max, Littauer, Ross, Collins, Jessica, Lucas, Nisha, Nogueira, Raul G, Simard, J Marc, Wald, Michael, Dawson, Kate, and Kimberly, W Taylor

Published
2024
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22. A novel long non-coding RNA connects obesity to impaired adipocyte function

Author

Lluch, Aina, Latorre, Jèssica, Oliveras-Cañellas, Núria, Fernández-Sánchez, Ana, Moreno-Navarrete, José M., Castells-Nobau, Anna, Comas, Ferran, Buxò, Maria, Rodríguez-Hermosa, José I., Ballester, María, Espadas, Isabel, Martín-Montalvo, Alejandro, Zhang, Birong, Zhou, You, Burkhardt, Ralph, Höring, Marcus, Liebisch, Gerhard, Castellanos-Rubio, Ainara, Santin, Izortze, Kar, Asha, Laakso, Markku, Pajukanta, Päivi, Olkkonen, Vesa M., Fernández-Real, José M., and Ortega, Francisco J.

Published
2024
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25. Association of dead space fraction to mortality in patients with COVID-19-related ARDS: A historical cohort observational study

Author

Carvajal, Carlos, Giraldo Ramirez, Nelson Darío, De La Hoz Castro, Andrés David, Vidal Vargas, Carlos Guillermo, Pacheco, Hemel Antonio, Fernández Sánchez, David, González Salazar, Laura Vannesa, Romero Otta, Silvia Stella, Vergara Jaimes, Silvia, Bolivar Ospina, Juan Fernando, Correa Céspedes, Juliana, Narvaez Orozco, Alejandro, Donado, Jorge Hernando, Cadavid, Carlos Alberto, and De La Rosa, Gisela

Published
2024
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26. Imported malaria cases by Plasmodium falciparum and Plasmodium vivax in Mexican territory: Potential impact of the migration crisis

Author

Loyola-Cruz, Miguel Ángel, Durán-Manuel, Emilio Mariano, Cruz-Cruz, Clemente, Bravata-Alcántara, Juan Carlos, Gutierrez-Muñoz, Victor Hugo, Márquez-Valdelamar, Laura Margarita, Leal-Escobar, Beatriz, Vásquez-Jiménez, Enzo, Cureño-Díaz, Mónica Alethia, Lugo-Zamudio, Gustavo Esteban, Calzada-Mendoza, Claudia Camelia, López-Leal, Gamaliel, Castro-Escarpulli, Graciela, Rojas-Bernabé, Araceli, Fernández-Sánchez, Verónica, Plascencia-Nieto, Estibeyesbo Said, Nieto-Velázquez, Nayeli Goreti, and Bello-López, Juan Manuel

Published
2024
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27. Asociación de fracción de espacio muerto con la mortalidad en pacientes con síndrome de dificultad respiratoria aguda por COVID-19: Un estudio observacional de una cohorte histórica

Author

Carvajal, Carlos, Giraldo Ramirez, Nelson Darío, de la Hoz Castro, Andrés David, Vidal Vargas, Carlos Guillermo, Pacheco, Hemel Antonio, Fernández Sánchez, David, González Salazar, Laura Vannesa, Romero Otta, Silvia Stella, Vergara Jaimes, Silvia, Bolívar Ospina, Juan Fernando, Correa Céspedes, Juliana, Narváez Orozco, Alejandro, Donado, Jorge Hernando, Cadavid, Carlos Alberto, and de la Rosa, Gisela

Published
2024
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29. Language Matters: Exploring Preferred Terms for Diverse Populations

Author

Higinio Fernandez-Sanchez, Emmanuel Akwasi Marfo, Diane Santa Maria, and Mercy Mumba

Subjects
Nursing, RT1-120
Abstract

This article explores the significance of employing preferred terms and inclusive language in research practices concerning diverse populations. It highlights how inappropriate terminology can lead to labeling, stereotyping, and stigma, particularly for equity-denied groups. The study aimed to identify and analyze terminology preferences for diverse communities by major international organizations. Through a systematic environmental scan methodology, data were collected from 12 prominent organizations. The results indicate a concerted effort toward adopting inclusive language, with organizations favoring respectful and accurate terminology. For instance, terms like “people made vulnerable by systemic inequities” and “migrant workers” were preferred over outdated or stigmatizing alternatives. The discussion emphasizes the importance of identifying conflicting terms and trends in terminology preferences over time. We recommend prioritizing the use of preferred terms to promote respectful and accurate discourse, with a focus on person-centered language. Ultimately, the findings underscore the critical role of language in shaping perceptions and attitudes toward diverse communities, and advocate for continued efforts to promote inclusivity and equity in research, policy, and practice.

Published
2024
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30. Assessment of the likelihood of hypothyroidism in dogs diagnosed with and treated for hypothyroidism at primary care practices: 102 cases (2016‐2021)

Author

Victoria Travail, Carolina Fernandez Sanchez, Jose M. Costo, Nicola Valentine, Megan Conroy, Venessa Lee, Dimitrios Bouziopoulos, Kathryn Bateman, Emma Gatehouse, Judith Cruzado‐Perez, Danica Pollard, Valerie Lamb, Florence Juvet, and Darren Kelly

Subjects
endocrinology, levothyroxine, thyroid gland, thyroxine, total T4, Veterinary medicine, SF600-1100
Abstract

Abstract Background There is a possibility that an incorrect diagnosis of hypothyroidism could be made in euthyroid dogs, and the prevalence of hypothyroidism in the dog population remains unknown. Objectives To retrospectively assess the percentage of dogs diagnosed with, and treated for, hypothyroidism at first opinion practice which are likely to be hypothyroid and require levothyroxine supplementation. Animals One hundred two client‐owned dogs were included in this study. Materials and Methods The computerized databases of 7 first opinion practices were searched to identify dogs treated with levothyroxine supplementation. Three European College of Veterinary Internal Medicine—Companian Animals (ECVIM‐CA) diplomates independently assigned 1 of 4 clinical assessments to each case as follows: confirmed or likely hypothyroid, hypothyroidism suspected but not confirmed, hypothyroidism considered unlikely, and no reason to suspect hypothyroidism. They commented as to whether or not they thought levothyroxine supplementation was appropriate. Results The clinical assessments of “confirmed or likely hypothyroid”; “Hypothyroidism suspected but not confirmed”; “Hypothyroidism considered unlikely”; and “No reason to suspect hypothyroidism” was assigned respectively by Clinician 1 to 38.2%, 5.9%, 3.9%, and 52% of cases, by Clinician 2 to 48%, 22.6%, 22.6%, 6.9% of cases, and by Clinician 3 to 55.9%, 11.8%, 13.7% and 18.6%. Clinician 1, Clinician 2, and Clinician 3 considered levothyroxine supplementation not indicated in 58.8%, 52.9%, and 45.1% of cases, respectively. Conclusion These results support the concern that hypothyroidism might be overly and incorrectly diagnosed in first opinion practice, and that thyroid function testing should be performed only in those dogs with a high pretest probability of the disease.

Published
2024
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31. Exploring Definitions and Predictors of Response to Biologics for Severe Asthma

Author

Scelo, Ghislaine, Tran, Trung N., Le, Tham T., Fagerås, Malin, Dorscheid, Delbert, Busby, John, Al-Ahmad, Mona, Al-Lehebi, Riyad, Altraja, Alan, Beastall, Aaron, Bergeron, Celine, Bjermer, Leif, Bjerrum, Anne S., Cano-Rosales, Diana Jimena, Canonica, Giorgio Walter, Carter, Victoria, Charriot, Jeremy, Christoff, George C., Cosio, Borja G., Denton, Eve, Fernandez-Sanchez, Maria Jose, Fonseca, João A., Gibson, Peter G., Goh, Celine, Heaney, Liam G., Heffler, Enrico, Hew, Mark, Iwanaga, Takashi, Katial, Rohit, Koh, Mariko S., Kuna, Piotr, Larenas-Linnemann, Désirée, Lehtimäki, Lauri, Mahboub, Bassam, Martin, Neil, Matsumoto, Hisako, Menzies-Gow, Andrew N., Papadopoulos, Nikolaos G., Patel, Pujan, Perez-De-Llano, Luis, Peters, Matthew, Pfeffer, Paul E., Popov, Todor A., Porsbjerg, Celeste M., Rhee, Chin K., Sadatsafavi, Mohsen, Taillé, Camille, Torres-Duque, Carlos A., Tsai, Ming-Ju, Ulrik, Charlotte S., Upham, John W., von Bülow, Anna, Wang, Eileen, Wechsler, Michael E., and Price, David B.

Published
2024
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35. Properties of Poincar\'{e} half-maps for planar linear systems and some direct applications to periodic orbits of piecewise systems

Author

Carmona, Victoriano, Fernández-Sánchez, Fernando, García-Medina, Elisabeth, and Novaes, Douglas D.

Subjects
Mathematics - Dynamical Systems, 34A25, 34A26, 34A36, 34C05
Abstract

This paper deals with fundamental properties of Poincar\'e half-maps defined on a straight line for planar linear systems. Concretely, we focus on the analyticity of the Poincar\'e half-maps, their series expansions (Taylor and Newton-Puiseux) at the tangency point and at infinity, the relative position between the graph of Poincar\'e half-maps and the bisector of the fourth quadrant, and the sign of their second derivatives. All these properties are essential to understand the dynamic behavior of planar piecewise linear systems. Accordingly, we also provide some of their most immediate, but non-trivial, consequences regarding periodic orbits.

Published
2021
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38. ADAMTS13 recovery in acute thrombotic thrombocytopenic purpura after caplacizumab therapy

Author

Abio Calvete, Mariola, Albert, Albert, Alberto López García, Alberto, Alegre, Adrian, Alkorta Eizagirre, Aitziber, Alonso Escobar, María Nieves, Alonso Madrigal, Cristina, Amunarriz, Cristina, Antelo Caamaño, María Luisa, Arbona Castaño, Cristina, Ballester Ruiz, Maria Carmen, Ballina Martín, Belén, Berberana Fernández de Murias, Margarita, Berrueco Moreno, Ruben, Bueno, Jose Luis, Calderón López, María Teresa, Chica Gullón, Esther, Cid Vidal, Joan, Contreras Barbeta, Enric, Cuéllar Pérez-Ávila, Clara, de la Rubia Comos, Javier, Del Orbe Barreto, Rafael Andres, Del Río Garma, Julio, Díaz Valdés, José R., Diaz-Ricart, Maribel, Diez Gallarreta, Zuriñe, Dueñas Hernando, Virginia, Eguia, Blanca, Escoda, Lourdes, Fernández Docampo, Marta, Fernandez Fuertes, Fernando, Fernández Muñoz, Hermogenes, Fernández Sánchez de Mora, Maria Carmen, Fernandez Zarzoso, Miguel, Fidalgo, Teresa, Flores Ballester, Elena, Fonte Feal, Cristina, Galvez, Francisco Javier, Garcia Arroba Peinado, Jose, García Candel, Faustino, Garcia Erce, Jose Antonio, García Gala, José María, Gimeno, JJ, Gómez, Delia, Gómez Seguí, Inés, Gomez Vazquez, Maria Jesus, Gonzalez, Carlos, González Fernández, Fernando Ataulfo, Gonzalez Porras, Jose Ramon, Gonzalez Rodriguez, Victoria Paz, Goterris Viciedo, Rosa, Guerra Domínguez, Luisa, Guillén García, Helga, Hernandez, Adoracion, Hernández Castellet, José Carlos, Hernandez Mohedo, Francisca, Hernandez Vazquez, Laura, Hidalgo Soto, Marta, Hong Tam, Azueg Hang, Kerguelen Fuentes, Ana Lilia, Leal Bento, Marta, Lopes, Raquel, López, Olga, López Chuliá, Francisca, Maria Jose Busto, Maria Jose, Martín Hernández, María Paz, Martinez Estefano, Elvira, Martinez Nieto, Jorge, Martinez Redondo, Consuelo, Martinez Revuelta, Eva, Medina Marrero, Laura, Mingot Castellano, María Eva, Morales Sanz, María Dolores, Moreno, Gemma, Moreno Beltrán, Mª Esperanza, Moreno Chulilla, Jose Antonio, Nistal Gil, Sara, Oliva Hernandez, Ana Yurena, Pascual, Teresa, Pascual Izquierdo, Crisina, Paumard Rodríguez, Elena, Pecos, Patricia, Peña Marcos, Francisco, Pereira Coelho, Daniela Sofia, Pérez Segura, Gloria Maria, Perez-Lopez, Olga, Prieto Pareja, Elena, Ramiro, Laia, Richart López, Luis Alberto, Rodriguez Dominguez, Maria Jesus, Rodriguez Nuñez, Antonio, Ruiz Sainz, María Elena, Saez Serrano, Isabel, Salinas Argente, Ramón, Sanchez, Maria Elena, Sanchez Anton, Piva, Sánchez Fernández, Mª Soledad, Sebastian, Elena, Simona, Gabriela, Solanich Moreno, Xabier, Soledad Casado, Soledad, Tallón, Jose David, Turcu, Violeta, Valledor Méndez, Manuel, Vidan Y Estevez, Julia, Viejo Llorente, Aurora, Bienert, Álvaro, Serrano, Alfons, Llorente, Laura, Campuzano, Verónica, Tallón, Inmaculada, Pons, Verónica, Linares, Mónica, Valles, Ana, Martínez Francés, Antonio, Freiria, Carmen, González Arias, Elena, Araujo, Enmanuel, Marco de Lucas, Fernando, López, Juan Antonio, Uribe Barrientos, Marisol, Calviño, Michael, Gómez Calafat, Montse, Marco Vera, Pascual, Fariña, Sabela, Zalba, Saioa, Monsalvo, Silvia, Escamilla, Virginia, Mingot-Castellano, María-Eva, García-Candel, Faustino, Martínez-Nieto, Jorge, García-Arroba, José, de la Rubia-Comos, Javier, Gómez-Seguí, Inés, Paciello-Coronel, María-Liz, Valcárcel-Ferreiras, David, Jiménez, Moraima, Cid, Joan, Lozano, Miquel, García-Gala, José-María, Angós-Vazquez, Sonia, Vara-Pampliega, Miriam, Guerra-Domínguez, Luisa, Ávila-Idrobo, Laura-Francisca, Oliva-Hernandez, Ana, Zalba-Marcos, Saioa, Tallón-Ruiz, Inmaculada, Ortega-Sánchez, Sandra, Goterris-Viciedo, Rosa, Moreno-Jiménez, Gemma, Domínguez-Acosta, Lourdes, Araiz-Ramírez, María, Hernández-Mateos, Luis, Flores-Ballesteros, Elena, del Río-Garma, Julio, and Pascual-Izquierdo, Cristina

Published
2024
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43. SAQ: semi-algebraic quartet reconstruction method

Author

Casanellas, Marta, Fernández-Sánchez, Jesús, and Garrote-López, Marina

Subjects
Quantitative Biology - Populations and Evolution
Abstract

We present the phylogenetic quartet reconstruction method SAQ (Semi-algebraic quartet reconstruction). SAQ is consistent with the most general Markov model of nucleotide substitution and, in particular, it allows for rate heterogeneity across lineages. Based on the algebraic and semi-algebraic description of distributions that arise from the general Markov model on a quartet, the method outputs normalized weights for the three trivalent quartets (which can be used as input of quartet-base methods). We show that SAQ is a highly competitive method that outperforms most of the well known reconstruction methods on data simulated under the general Markov model on 4-taxon trees. Moreover, it also achieves a high performance on data that violates the underlying assumptions.

Published
2020

44. Improved Max-value Entropy Search for Multi-objective Bayesian Optimization with Constraints

Author

Fernández-Sánchez, Daniel, Garrido-Merchán, Eduardo C., and Hernández-Lobato, Daniel

Subjects
Statistics - Machine Learning, Computer Science - Machine Learning
Abstract

We present MESMOC+, an improved version of Max-value Entropy search for Multi-Objective Bayesian optimization with Constraints (MESMOC). MESMOC+ can be used to solve constrained multi-objective problems when the objectives and the constraints are expensive to evaluate. MESMOC+ works by minimizing the entropy of the solution of the optimization problem in function space, i.e., the Pareto frontier, to guide the search for the optimum. The cost of MESMOC+ is linear in the number of objectives and constraints. Furthermore, it is often significantly smaller than the cost of alternative methods based on minimizing the entropy of the Pareto set. The reason for this is that it is easier to approximate the required computations in MESMOC+. Moreover, MESMOC+'s acquisition function is expressed as the sum of one acquisition per each black-box (objective or constraint). Thus, it can be used in a decoupled evaluation setting in which one chooses not only the next input location to evaluate, but also which black-box to evaluate there. We compare MESMOC+ with related methods in synthetic and real optimization problems. These experiments show that the entropy estimation provided by MESMOC+ is more accurate than that of previous methods. This leads to better optimization results. MESMOC+ is also competitive with other information-based methods for constrained multi-objective Bayesian optimization, but it is significantly faster.

Published
2020

45. The embedding problem for Markov matrices

Author

Casanellas, Marta, Fernández-Sánchez, Jesús, and Roca-Lacostena, Jordi

Subjects
Mathematics - Probability, Mathematics - Spectral Theory, 60J10, 60J27, 15B51, 15A16
Abstract

Characterizing whether a Markov process of discrete random variables has an homogeneous continuous-time realization is a hard problem. In practice, this problem reduces to deciding when a given Markov matrix can be written as the exponential of some rate matrix (a Markov generator). This is an old question known in the literature as the embedding problem (Elfving37), which has been only solved for matrices of size $2\times 2$ or $3\times 3$. In this paper, we address this problem and related questions and obtain results in two different lines. First, for matrices of any size, we give a bound on the number of Markov generators in terms of the spectrum of the Markov matrix. Based on this, we establish a criterion for deciding whether a generic Markov matrix (different eigenvalues) is embeddable and propose an algorithm that lists all its Markov generators. Then, motivated and inspired by recent results on substitution models of DNA, we focus in the $4\times 4$ case and completely solve the embedding problem for any Markov matrix. The solution in this case is more concise as the embeddability is given in terms of a single condition.

Published
2020

46. An open set of $4\times4$ embeddable matrices whose principal logarithm is not a Markov generator

Author

Casanellas, Marta, Fernández-Sánchez, Jesús, and Roca-Lacostena, Jordi

Subjects
Mathematics - Probability, Mathematics - Spectral Theory, 60J10, 60J27, 15B51, 15A16
Abstract

A Markov matrix is embeddable if it can represent a homogeneous continuous-time Markov process. It is well known that if a Markov matrix has real and pairwise-different eigenvalues, then the embeddability can be determined by checking whether its principal logarithm is a rate matrix or not. The same holds for Markov matrices close enough to the identity matrix or that rule a Markov process subjected to certain restrictions. In this paper we prove that this criterion cannot be generalized and we provide open sets of Markov matrices that are embeddable and whose principal logarithm is a not a rate matrix.

Published
2020

47. Rank conditions on phylogenetic networks

Author

Casanellas, Marta and Fernández-Sánchez, Jesús

Subjects
Quantitative Biology - Populations and Evolution, 92B10, 92D15
Abstract

Less rigid than phylogenetic trees, phylogenetic networks allow the description of a wider range of evolutionary events. In this note, we explain how to extend the rank invariants from phylogenetic trees to phylogenetic networks evolving under the general Markov model and the equivariant models., Comment: 5 pages, 1 figure. This paper will appear in Research Perspectives CRM Barcelona, Spring 2019, vol. 10, in Trends in Mathematics Springer-Birkhauser

Published
2020

48. Neuron Characterization in Complex Cultures Using a Combined YOLO and U-Net Segmentation Approach

Author

Puerta, Paula, Öztürk, Berke, Khojasteh, Samad Barri, González, Víctor M., Villar, José R., Serrano-Pertierra, Esther, Novelli, Antonello, Fernández-Sánchez, M. Teresa, Río-Álvarez, Ángel, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, García Bringas, Pablo, editor, Pérez García, Hilde, editor, Martínez de Pisón, Francisco Javier, editor, Martínez Álvarez, Francisco, editor, Troncoso Lora, Alicia, editor, Herrero, Álvaro, editor, Calvo Rolle, José Luis, editor, Quintián, Héctor, editor, and Corchado, Emilio, editor

Published
2023
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49. Convergence of Copulas Revisited: Different Notions of Convergence and Their Interrelations

Author

Dietrich, Nicolas, Fernández-Sánchez, Juan, Trutschnig, Wolfgang, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, García-Escudero, Luis A., editor, Gordaliza, Alfonso, editor, Mayo, Agustín, editor, Lubiano Gomez, María Asunción, editor, Gil, Maria Angeles, editor, Grzegorzewski, Przemyslaw, editor, and Hryniewicz, Olgierd, editor

Published
2023
Full Text
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