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1. Clinical features of post-COVID-19 period. Results of the international register 'Dynamic analysis of comorbidities in SARS-CoV-2 survivors (AKTIV SARS-CoV-2)'. Data from 6-month follow-up

Author

G. P. Arutyunov, E. I. Tarlovskaya, A. G. Arutyunov, Yu. N. Belenkov, A. O. Konradi, Yu. M. Lopatin, A. P. Rebrov, S. N. Tereshchenko, A. I. Chesnikova, H. G. Hayrapetyan, A. P. Babin, I. G. Bakulin, N. V. Bakulina, L. A. Balykova, A. S. Blagonravova, M. V. Boldina, A. R. Vaisberg, A. S. Galyavich, V. V. Gomonova, N. Yu. Grigorieva, I. V. Gubareva, I. V. Demko, A. V. Evzerikhina, A. V. Zharkov, U. K. Kamilova, Z. F. Kim, T. Yu. Kuznetsova, N. V. Lareva, E. V. Makarova, S. V. Malchikova, S. V. Nedogoda, M. M. Petrova, I. G. Pochinka, K. V. Protasov, D. N. Protsenko, D. Yu. Ruzanau, S. A. Sayganov, A. Sh. Sarybaev, N. M. Selezneva, A. B. Sugraliev, I. V. Fomin, O. V. Khlynova, O. Yu. Chizhova, I. I. Shaposhnik, D. A. Shchukarev, A. K. Abdrahmanova, S. A. Avetisian, H. G. Avoyan, K. K. Azarian, G. T. Aimakhanova, D. A. Ayipova, A. Ch. Akunov, M. K. Alieva, A. V. Aparkina, O. R. Aruslanova, E. Yu. Ashina, O. Yu. Badina, O. Yu. Barisheva, T. I. Batluk, A. S. Batchayeva, R. A. Bashkinov, A. M. Bitieva, I. U. Bikhteyev, N. A. Borodulina, M. V. Bragin, A. M. Budu, G. A. Bykova, K. R. Vagapova, D. D. Varlamova, N. N. Vezikova, E. A. Verbitskaya, O. E. Vilkova, E. A. Vinnikova, V. V. Vustina, E. A. Gаlova, V. V. Genkel, E. I. Gorshenina, E. V. Grigorieva, E. Yu. Gubareva, G. M. Dabylova, I. A. Demchenko, O. Yu. Dolgikh, M. Y. Duyshobayev, D. S. Evdokimov, K. E. Egorova, A. N. Ermilova, A. E. Zheldybayeva, N. V. Zarechnova, Yu. D. Zimina, S. Yu. Ivanova, E. Yu. Ivanchenko, M. V. Ilina, M. V. Kazakovtseva, E. V. Kazymova, Yu. S. Kalinina, N. A. Kamardina, A. M. Karachenova, I. A. Karetnikov, N. A. Karoli, M. K. Karsiev, D. S. Кaskaeva, K. F. Kasymova, Zh. B. Kerimbekova, A. Sh. Kerimova, E. S. Kim, N. V. Kiseleva, D. A. Klimenko, A. V. Klimova, O. V. Kovalishena, E. V. Kolmakova, T. P. Kolchinskaya, M. I. Kolyadich, O. V. Kondriakova, M. P. Konoval, D. Yu. Konstantinov, E. A. Konstantinova, V. A. Kordukova, E. V. Koroleva, A. Yu. Kraposhina, T. V. Kriukova, A. S. Kuznetsova, T. Yu. Kuzmina, K. V. Kuzmichev, Ch. K. Kulchoroeva, T. V. Kuprina, I. M. Kouranova, L. V. Kurenkova, N. Yu. Kurchugina, N. A. Kushubakova, V. I. Levankova, N. A. Lyubavina, N. A. Magdeyeva, K. V. Mazalov, V. I. Majseenko, A. S. Makarova, A. M. Maripov, A. A. Marusina, E. S. Melnikov, N. B. Moiseenko, F. N. Muradova, R. G. Muradyan, Sh. N. Musaelian, A. O. Myshak, E. S. Nekaeva, N. M. Nikitina, B. B. Ogurlieva, A. A. Odegova, Yu. M. Omarova, N. A. Omurzakova, Sh. O. Ospanova, E. V. Pahomova, L. D. Petrov, S. S. Plastinina, V. A. Pogrebetskaya, D. V. Polyakov, D. S. Polyakov, E. V. Ponomarenko, L. L. Popova, N. A. Prokofeva, I. A. Pudova, N. A. Rakov, A. N. Rakhimov, N. A. Rozanova, S. Serikbolkyzy, A. A. Simonov, V. V. Skachkova, D. V. Soloveva, I. A. Soloveva, I. M. Sukhomlinova, A. G. Sushilova, D. R. Tagayeva, Yu. V. Titojkina, E. P. Tikhonova, D. S. Tokmin, A. A. Tolmacheva, M. S. Torgunakova, K. V. Trenogina, N. A. Trostianetckaia, D. A. Trofimov, M. A. Trubnikova, A. A. Tulichev, A. T. Tursunova, N. D. Ulanova, O. V. Fatenkov, O. V. Fedorishina, T. S. Fil, I. Yu. Fomina, I. S. Fominova, I. A. Frolova, S. M. Tsvinger, V. V. Tsoma, M. B. Cholponbaeva, T. I. Chudinovskikh, O. A. Shevchenko, T. V. Sheshina, E. A. Shishkina, K. Yu. Shishkov, S. Yu. Sherbakov, and E. A. Yausheva

Subjects
covid-19, aktiv register, cardiovascular diseases, diabetes, postcovid-19 period, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Aim. To study the clinical course specifics of coronavirus disease 2019 (COVID-19) and comorbid conditions in COVID-19 survivors 3, 6, 12 months after recovery in the Eurasian region according to the AKTIV register. Material and methods.The AKTIV register was created at the initiative of the Eurasian Association of Therapists. The AKTIV register is divided into 2 parts: AKTIV 1 and AKTIV 2. The AKTIV 1 register currently includes 6300 patients, while in AKTIV 2 — 2770. Patients diagnosed with COVID-19 receiving in- and outpatient treatment have been anonymously included on the registry. The following 7 countries participated in the register: Russian Federation, Republic of Armenia, Republic of Belarus, Republic of Kazakhstan, Kyrgyz Republic, Republic of Moldova, Republic of Uzbekistan. This closed multicenter register with two nonoverlapping branches (in- and outpatient branch) provides 6 visits: 3 in-person visits during the acute period and 3 telephone calls after 3, 6, 12 months. Subject recruitment lasted from June 29, 2020 to October 29, 2020. Register will end on October 29, 2022. A total of 9 fragmentary analyzes of the registry data are planned. This fragment of the study presents the results of the post-hospitalization period in COVID-19 survivors after 3 and 6 months. Results. According to the AKTIV register, patients after COVID-19 are characterized by long-term persistent symptoms and frequent seeking for unscheduled medical care, including rehospitalizations. The most common causes of unplanned medical care are uncontrolled hypertension (HTN) and chronic coronary artery disease (CAD) and/or decompensated type 2 diabetes (T2D). During 3- and 6-month follow-up after hospitalization, 5,6% and 6,4% of patients were diagnosed with other diseases, which were more often presented by HTN, T2D, and CAD. The mortality rate of patients in the post-hospitalization period was 1,9% in the first 3 months and 0,2% for 4-6 months. The highest mortality rate was observed in the first 3 months in the group of patients with class II-IV heart failure, as well as in patients with cardiovascular diseases and cancer. In the pattern of death causes in the post-hospitalization period, following cardiovascular causes prevailed (31,8%): acute coronary syndrome, stroke, acute heart failure. Conclusion. According to the AKTIV register, the health status of patients after COVID-19 in a serious challenge for healthcare system, which requires planning adequate health system capacity to provide care to patients with COVID-19 in both acute and post-hospitalization period.

Published
2021
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2. International register 'Dynamics analysis of comorbidities in SARS-CoV-2 survivors' (AKTIV SARS-CoV-2): analysis of predictors of short-term adverse outcomes in COVID-19

Author

G. P. Arutyunov, E. I. Tarlovskaya, A. G. Arutyunov, Y. N. Belenkov, A. O. Konradi, Y. M. Lopatin, A. P. Rebrov, S. N. Tereshchenko, A. I. Chesnikova, H. G. Hayrapetyan, A. P. Babin, I. G. Bakulin, N. V. Bakulina, L. A. Balykova, A. S. Blagonravova, M. V. Boldina, A. R. Vaisberg, A. S. Galyavich, V. V. Gomonova, N. U. Grigorieva, I. V. Gubareva, I. V. Demko, A. V. Evzerikhina, A. V. Zharkov, U. K. Kamilova, Z. F. Kim, T. Yu. Kuznetsova, N. V. Lareva, E. V. Makarova, S. V. Malchikova, S. V. Nedogoda, M. M. Petrova, I. G. Pochinka, K. V. Protasov, D. N. Protsenko, D. Yu. Ruzanov, S. A. Sayganov, A. Sh. Sarybaev, N. M. Selezneva, A. B. Sugraliev, I. V. Fomin, O. V. Khlynova, O. Yu. Chizhova, I. I. Shaposhnik, D. A. Schukarev, A. K. Abdrahmanova, S. A. Avetisian, H. G. Avoyan, K. K. Azarian, G. T. Aimakhanova, D. A. Ayipova, A. Ch. Akunov, M. K. Alieva, A. V. Aparkina, O. R. Aruslanova, E. Yu. Ashina, O. Y. Badina, O. Yu. Barisheva, A. S. Batchayeva, I. U. Bikhteyev, N. A. Borodulina, M. V. Bragin, A. M. Budu, L. A. Burygina, G. A. Bykova, D. D. Varlamova, N. N. Vezikova, E. A. Verbitskaya, O. E. Vilkova, E. A. Vinnikova, V. V. Vustina, E. A. Gаlova, V. V. Genkel, E. I. Gorshenina, R. V. Gostishev, E. V. Grigorieva, E. Yu. Gubareva, G. M. Dabylova, A. I. Demchenko, O. Yu. Dolgikh, I. A. Duvanov, M. Y. Duyshobayev, D. S. Evdokimov, K. E. Egorova, A. N. Ermilova, A. E. Zheldybayeva, N. V. Zarechnova, S. Yu. Ivanova, E. Yu. Ivanchenko, M. V. Ilina, M. V. Kazakovtseva, E. V. Kazymova, Yu. S. Kalinina, N. A. Kamardina, A. M. Karachenova, I. A. Karetnikov, N. A. Karoli, O. V. Karpov, M. Kh. Karsiev, D. S. Kaskaeva, K. F. Kasymova, Zh. B. Kerimbekova, A. Sh. Kerimova, E. S. Kim, N. V. Kiseleva, D. A. Klimenko, A. V. Klimova, O. V. Kovalishena, E. V. Kolmakova, T. P. Kolchinskaya, M. I. Kolyadich, O. V. Kondriakova, M. P. Konoval, D. Yu. Konstantinov, E. A. Konstantinova, V. A. Kordukova, E. V. Koroleva, A. Yu. Kraposhina, T. V. Kriukova, A. S. Kuznetsova, T. Y. Kuzmina, K. V. Kuzmichev, Ch. K. Kulchoroeva, T. V. Kuprina, I. V. Kouranova, L. V. Kurenkova, N. Yu. Kurchugina, N. A. Kushubakova, V. I. Levankova, M. E. Levin, N. A. Lyubavina, N. A. Magdeyeva, K. V. Mazalov, V. I. Majseenko, A. S. Makarova, A. M. Maripov, A. A. Marusina, E. S. Melnikov, N. B. Moiseenko, F. N. Muradova, R. G. Muradyan, Sh. N. Musaelian, N. M. Nikitina, B. B. Ogurlieva, A. A. Odegova, Yu. M. Omarova, N. A. Omurzakova, Sh. O. Ospanova, E. V. Pahomova, L. D. Petrov, S. S. Plastinina, V. A. Pogrebetskaya, D. S. Polyakov, E. V. Ponomarenko, L. L. Popova, N. A. Prokofeva, I. A. Pudova, N. A. Rakov, A. N. Rakhimov, N. A. Rozanova, S. Serikbolkyzy, A. A. Simonov, V. V. Skachkova, L. A. Smirnova, D. V. Soloveva, I. A. Soloveva, F. M. Sokhova, A. K. Subbotin, I. M. Sukhomlinova, A. G. Sushilova, D. R. Tagayeva, Yu. V. Titojkina, E. P. Tikhonova, D. S. Tokmin, M. S. Torgunakova, K. V. Trenogina, N. A. Trostianetckaia, D. A. Trofimov, A. A. Tulichev, D. I. Tupitsin, A. T. Tursunova, N. D. Ulanova, O. V. Fatenkov, O. V. Fedorishina, T. S. Fil, I. Yu. Fomina, I. S. Fominova, I. A. Frolova, S. M. Tsvinger, V. V. Tsoma, M. B. Cholponbaeva, T. I. Chudinovskikh, L. D. Shakhgildyan, O. A. Shevchenko, T. V. Sheshina, E. A. Shishkina, K. Yu. Shishkov, S. Y. Sherbakov, and E. A. Yausheva

Subjects
aktiv register, covid-19, multimorbidity, mortality predictors, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

The international AKTIV register presents a detailed description of out- and inpatients with COVID-19 in the Eurasian region. It was found that hospitalized patients had more comorbidities. In addition, these patients were older and there were more men than among outpatients. Among the traditional risk factors, obesity and hypertension had a significant negative effect on prognosis, which was more significant for patients 60 years of age and older. Among comorbidities, CVDs had the maximum negative effect on prognosis, and this effect was more significant for patients 60 years of age and older. Among other comorbidities, type 2 and 1 diabetes, chronic kidney disease, chronic obstructive pulmonary disease, cancer and anemia had a negative impact on the prognosis. This effect was also more significant (with the exception of type 1 diabetes) for patients 60 years and older. The death risk in patients with COVID-19 depended on the severity and type of multimorbidity. Clusters of diseases typical for deceased patients were identified and their impact on prognosis was determined. The most unfavorable was a cluster of 4 diseases, including hypertension, coronary artery disease, heart failure, and diabetes mellitus. The data obtained should be taken into account when planning measures for prevention (vaccination priority groups), treatment and rehabilitation of COVID-19 survivors.

Published
2021
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3. International register 'Dynamics analysis of comorbidities in SARS-CoV-2 survivors' (AKTIV) and the register 'Analysis of hospitalizations of comorbid patients infected during the second wave of SARS-CoV-2 outbreak' (AKTIV 2)

Author

G. P. Arutyunov, E. I. Tarlovskaya, A. G. Arutyunov, Y. N. Belenkov, A. O. Konradi, Y. M. Lopatin, A. P. Rebrov, S. N. Tereshchenko, A. I. Chesnikova, H. G. Hayrapetyan, A. P. Babin, I. G. Bakulin, N. V. Bakulina, l. A. Balykova, A. S. Blagonravova, M. V. Boldina, A. R. Vaisberg, A. S. Galyavich, V. V. Gomonova, N. U. Grigorieva, I. V. Gubareva, I. V. Demko, A. V. Evzerikhina, A. V. Zharkov, U. K. Kamilova, Z. F. Kim, T. Yu. Kuznetsova, N. V. Lareva, E. V. Makarova, S. V. Malchikova, S. V. Nedogoda, M. M. Petrova, I. G. Pochinka, K. V. Protasov, D. N. Protsenko, D. Yu. Ruzanov, S. A. Sayganov, A. Sh. Sarybaev, N. M. Selezneva, A. B. Sugraliev, I. V. Fomin, O. V. Khlynova, O. Yu. Chizhova, I. I. Shaposhnik, D. A. Sсhukarev, A. K. Abdrahmanova, S. A. Avetisian, H. G. Avoyan, K. K. Azarian, G. T. Aimakhanova, D. A. Ayipova, A. Ch. Akunov, M. K. Alieva, A. V. Aparkina, O. R. Aruslanova, E. Yu. Ashina, O. Y. Badina, O. Yu. Barisheva, A. S. Batchayeva, A. M. Bitieva, I. U. Bikhteyev, N. A. Borodulina, M. V. Bragin, A. M. Budu, L. A. Burygina, G. A. Bykova, D. D. Varlamova, N. N. Vezikova, E. A. Verbitskaya, O. E. Vilkova, E. A. Vinnikova, V. V. Vustina, E. A. Gаlova, V. V. Genkel, E. I. Gorshenina, E. V. Grigorieva, E. Yu. Gubareva, G. M. Dabylova, A. I. Demchenko, O. Yu. Dolgikh, I. A. Duvanov, M. Y. Duyshobayev, D. S. Evdokimov, K. E. Egorova, A. N. Ermilova, A. E. Zheldybayeva, N. V. Zarechnova, S. Yu. Ivanova, E. Yu. Ivanchenko, M. V. Ilina, M. V. Kazakovtseva, E. V. Kazymova, Yu. S. Kalinina, N. A. Kamardina, A. M. Karachenova, I. A. Karetnikov, N. A. Karoli, O. V. Karpov, M. Kh. Karsiev, D. S. Кaskaeva, K. F. Kasymova, Zh. B. Kerimbekova, A. Sh. Kerimova, E. S. Kim, N. V. Kiseleva, D. A. Klimenko, A. V. Klimova, O. V. Kovalishena, E. V. Kolmakova, T. P. Kolchinskaya, M. I. Kolyadich, O. V. Kondriakova, M. P. Konoval, D. Yu. Konstantinov, E. A. Konstantinova, V. A. Kordukova, E. V. Koroleva, A. Yu. Kraposhina, T. V. Kriukova, A. S. Kuznetsova, T. Y. Kuzmina, K. V. Kuzmichev, Ch. K. Kulchoroeva, T. V. Kuprina, I. M. Kouranova, L. V. Kurenkova, N. Yu. Kurchugina, N. A. Kushubakova, V. I. Levankova, M. E. Levin, N. A. Lyubavina, N. A. Magdeyeva, K. V. Mazalov, V. I. Majseenko, A. S. Makarova, A. M. Maripov, A. A. Marusina, E. S. Melnikov, N. B. Moiseenko, F. N. Muradova, R. G. Muradyan, Sh. N. Musaelian, N. M. Nikitina, B. B. Ogurlieva, A. A. Odegova, Yu. M. Omarova, N. A. Omurzakova, Sh. O. Ospanova, E. V. Pahomova, L. D. Petrov, S. S. Plastinina, V. A. Pogrebetskaya, D. S. Polyakov, E. V. Ponomarenko, L. L. Popova, N. A. Prokofeva, I. A. Pudova, N. A. Rakov, A. N. Rakhimov, N. A. Rozanova, S. Serikbolkyzy, A. A. Simonov, V. V. Skachkova, L. A. Smirnova, D. V. Soloveva, I. A. Soloveva, F. M. Sokhova, A. K. Subbotin, I. M. Sukhomlinova, A. G. Sushilova, D. R. Tagayeva, Yu. V. Titojkina, E. P. Tikhonova, D. S. Tokmin, M. S. Torgunakova, K. V. Trenogina, N. A. Trostianetckaia, D. A. Trofimov, A. A. Tulichev, D. I. Tupitsin, A. T. Tursunova, A. A. Tiurin, N. D. Ulanova, O. V. Fatenkov, O. V. Fedorishina, T. S. Fil, I. Yu. Fomina, I. S. Fominova, I. A. Frolova, S. M. Tsvinger, V. V. Tsoma, M. B. Cholponbaeva, T. I. Chudinovskikh, L. D. Shakhgildyan, O. A. Shevchenko, T. V. Sheshina, E. A. Shishkina, K. Yu. Shishkov, S. Y. Sherbakov, and E. A. Yausheva

Subjects
sars-cov-2, registry, covid-19, comorbidity, risk, multimorbidity, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

The organizer of the registers “Dynamics analysis of comorbidities in SARSCoV-2 survivors” (AKTIV) and “Analysis of hospitalizations of comorbid patients infected during the second wave of SARS-CoV-2 outbreak” (AKTIV 2) is the Eurasian Association of Therapists (EAT). Currently, there are no clinical registries in the Eurasian region designed to collect and analyze information on long-term outcomes of COVID-19 survivors with comorbid conditions. The aim of the register is to assess the impact of a novel coronavirus infection on long-term course of chronic non-communicable diseases 3, 6, 12 months after recovery, as well as to obtain information on the effect of comorbidity on the severity of COVID-19. Analysis of hospitalized patients of a possible second wave is planned for register “AKTIV 2”. To achieve this goal, the register will include men and women over 18 years of age diagnosed with COVID-19 who are treated in a hospital or in outpatient basis. The register includes 25 centers in 5 federal districts of the Russian Federation, centers in the Republic of Armenia, the Republic of Kazakhstan, the Republic of Kyrgyzstan, the Republic of Belarus, the Republic of Moldova, and the Republic of Uzbekistan. The estimated capacity of the register is 5400 patients.

Published
2021
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4. International register 'Dynamics analysis of comorbidities in SARS-CoV-2 survivors' (AKTIV SARS-CoV-2): analysis of 1,000 patients

Author

G. P. Arutyunov, E. I. Tarlovskaya, A. G. Arutyunov, Y. N. Belenkov, A. O. Konradi, Y. M. Lopatin, S. N. Tereshchenko, A. P. Rebrov, A. I. Chesnikova, I. V. Fomin, N. V. Grigorieva, M. V. Boldina, A. R. Vaisberg, A. S. Blagonravova, E. V. Makarova, I. I. Shaposhnik, T. Yu. Kuznetsova, S. V. Malchikova, D. N. Protsenko, A. V. Evzerikhina, M. M. Petrova, I. V. Demko, D. V. Saphonov, H. G. Hayrapetyan, A. S. Galyavich, Z. F. Kim, A. B. Sugraliev, S. V. Nedogoda, V. V. Tsoma, S. A. Sayganov, V. V. Gomonova, I. V. Gubareva, A. Sh. Sarybaev, E. V. Koroleva, O. E. Vilkova, I. Y. Fomina, I. A. Pudova, D. V. Soloveva, N. V. Kiseleva, N. V. Zelyaeva, I. M. Kouranova, V. A. Pogrebetskaya, F. N. Muradova, O. Y. Badina, O. V. Kovalishena, E. A. Galova, S. S. Plastinina, N. A. Lyubavina, N. N. Vezikova, V. I. Levankova, S. Yu. Ivanova, A. N. Ermilova, R. G. Muradyan, R. V. Gostishev, E. P. Tikhonova, T. Y. Kuzmina, I. A. Soloveva, A. Yu. Kraposhina, M. I. Kolyadich, T. P. Kolchinskaya, V. V. Genkel, A. S. Kuznetsova, M. V. Kazakovtseva, A. A. Odegova, T. I. Chudinovskikh, S. V. Baramzina, N. A. Rozanova, A. Sh. Kerimova, N. A. Krivosheina, S. Y. Chukhlova, A. A. Levchenko, H. G. Avoyan, K. K. Azarian, Sh. N. Musaelian, S. A. Avetisian, M. E. Levin, O. V. Karpov, F. M. Sokhova, L. A. Burygina, T. V. Sheshina, A. A. Tiurin, O. Yu. Dolgikh, E. V. Kazymova, D. Yu. Konstantinov, O. A. Chumakova, O. V. Kondriakova, K. Yu. Shishkov, T. S. Fil, N. A. Prokofeva, M. P. Konoval, A. A. Simonov, A. M. Bitieva, N. A. Trostianetckaia, M. B. Cholponbaeva, Zh. B. Kerimbekova, M. Y. Duyshobayev, A. Ch. Akunov, N. A. Kushubakova, E. S. Melnikov, E. S. Kim, S. Y. Sherbakov, D. A. Trofimov, D. S. Evdokimov, D. A. Ayipova, I. A. Duvanov, A. K. Abdrahmanova, G. T. Aimakhanova, Sh. O. Ospanova, G. M. Dabylova, A. T. Tursunova, D. S. Xaskaeva, A. A. Tulichev, E. Yu. Ashina, V. A. Kordukova, O. Yu. Barisheva, K. E. Egorova, D. D. Varlamova, T. V. Kuprina, E. V. Pahomova, N. Yu. Kurchugina, I. A. Frolova, K. V. Mazalov, A. K. Subbotin, N. A. Kamardina, N. V. Zarechnova, E. M. Mamutova, L. A. Smirnova, A. V. Klimova, L. D. Shakhgildyan, D. S. Tokmin, D. I. Tupitsin, T. V. Kriukova, N. A. Rakov, and D. S. Polyakov

Subjects
aktiv register, sars-cov-2, covid-19, multimorbidity, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

COVID-19 is a severe infection with high mortality. The concept of the disease has been shaped to a greater extent on the basis of large registers from the USA, Spain, Italy, and China. However, there is no information on the disease characteristics in Caucasian patients.Therefore, we created an international register with the estimated capacity of 5,000 patients — Dynamics Analysis of Comorbidities in SARS-CoV-2 Survivors (AKTIV SARS-CoV-2), which brought together professionals from the Russian Federation, Republic of Armenia, Republic of Kazakhstan, and Kyrgyz Republic. The article presents the first analysis of the register involving 1,003 patients. It was shown that the most significant difference of the Caucasian population was the higher effect of multimorbidity on the mortality risk vs other registers. More pronounced effect on mortality of such diseases as diabetes, obesity, hypertension, chronic kidney disease, and age over 60 years was also revealed.

Published
2020
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5. [ACTIV SARS-CoV-2 registry (Analysis of Chronic Non-infectious Diseases Dynamics After COVID-19 Infection in Adult Patients). Assessment of impact of combined original comorbid diseases in patients with COVID-19 on the prognosis]

Author

Gregory P. Arutyunov, Ekaterina I. Tarlovskaya, Alexander G. Arutyunov, Yuri N. Belenkov, Alexandra O. Konradi, Yury M. Lopatin, Andrey P. Rebrov, Sergey N. Tereshchenko, Anna I. Chesnikova, Hamlet G. Hayrapetyan, Aleksandr P. Babin, Igor G. Bakulin, Natalia V. Bakulina, Larisa A. Balykova, Anna S. Blagonravova, Marina V. Boldina, Alexandra R. Vaisberg, Albert S. Galyavich, Veronika V. Gomonova, Natalia Yu. Grigorieva, Irina V. Gubareva, Irina V. Demko, Angelika V. Evzerikhina, Aleksandr V. Zharkov, Umida K. Kamilova, Zulfia F. Kim, Tatiana Yu. Kuznetsova, Natalia V. Lareva, Ekaterina V. Makarova, Svetlana V. Malchikova, Sergey V. Nedogoda, Marina M. Petrova, Ilya G. Pochinka, Konstantin V. Protasov, Denis N. Protsenko, Dmitry Yu. Ruzanau, Sergey A. Sayganov, Akpay S. Sarybaev, Natalia M. Selezneva, Akhmetzhan B. Sugraliev, Igor V. Fomin, Olga V. Khlynova, Olga Yu. Chizhova, Igor I. Shaposhnik, Dmitry A. Sh'ukarev, Айгуль K. Abdrahmanova, Susanna A. Avetisian, Hovhannes G. Avoyan, Karine K. Azarian, Galiya T. Aimakhanova, Dinara A. Ayipova, Almazbek Ch. Akunov, Marianna K. Alieva, Aliona V. Aparkina, Olga R. Aruslanova, Ekaterina Yu. Ashina, Olga Yu. Badina, Olga Yu. Barisheva, Alina S. Batchayeva, Anna M. Bitieva, Ismail U. Bikhteyev, Nataliya A. Borodulina, Maksim V. Bragin, Angela M. Budu, Galina M. Bykova, Kristina R. Vagapova, Darina D. Varlamova, Natalia N. Vezikova, Elena A. Verbitskaya, Olga E. Vilkova, Elena A. Vinnikova, Vera V. Vustina, Elena A. Galova, Vadim V. Genkel, Elena I. Gorshenina, Roman V. Gostishev, Elena V. Grigorieva, Ekaterina Yu. Gubareva, Gaukhar M. Dabylova, Anastasiya I. Demchenko, Oleg Yu. Dolgikh, Melis Y. Duyshobayev, Dmitrii S. Evdokimov, Ksenia E. Egorova, Anastasiia N. Ermilova, Aliya E. Zheldybayeva, Nataliya V. Zarechnova, Yuliia D. Zimina, Svetlana Yu. Ivanova, Elena Yu. Ivanchenko, Mariya V. Ilina, Maria V. Kazakovtseva, Elena V. Kazymova, Yuliya S. Kalinina, Nadezhda A. Kamardina, Anastasiya M. Karachenova, Igor A. Karetnikov, Nina A. Karoli, Magomed Kh. Karsiev, Daria S. Кaskaeva, Karina F. Kasymova, Zhainagul B. Kerimbekova, Ailar Sh. Kerimova, Eugeni S. Kim, Nina V. Kiseleva, Darya A. Klimenko, Anastasiia V. Klimova, Olga V. Kovalishena, Elena V. Kolmakova, Tatyana P. Kolchinskaya, Maria I. Kolyadich, Olga V. Kondriakova, Marina P. Konoval, Dmitryi Yu. Konstantinov, Elena A. Konstantinova, Vera A. Kordukova, Ekaterina V. Koroleva, Angelina Yu. Kraposhina, Tamara V. Kriukova, Alla S. Kuznetsova, Tatyana Yu. Kuzmina, Kirill V. Kuzmichev, Cholpon K. Kulchoroevna, Tatiana V. Kuprina, Irina M. Kouranova, Liliya V. Kurenkova, Natalia Yu. Kurchugina, Nadira A. Kushubakova, Valeriia I. Levankova, Natalia A. Lyubavina, Nadezhda A. Magdeyeva, Konstantin V. Mazalov, Viktoryia I. Majseenko, Aleksandra S. Makarova, Abdirashit M. Maripov, Anastasiia A. Marusina, Evgenii S. Melnikov, Nikita B. Moiseenko, Fazliniso N. Muradova, Rimma G. Muradyan, Shahane N. Musaelian, Anton O. Myshak, Ekaterina S. Nekaeva, Nataliia M. Nikitina, Bela B. Ogurlieva, Alla A. Odegova, Yuliia V. Omarova, Nazgul A. Omurzakova, Shynar O. Ospanova, Ekaterina V. Pahomova, Liviu D. Petrov, Svetlana S. Plastinina, Vera A. Pogrebetskaya, Dmitry S. Polyakov, Ekaterina V. Ponomarenko, Larisa L. Popova, Natalya A. Prokofeva, Inna A. Pudova, Nikita A. Rakov, Abdurakhmon N. Rahimov, Nadezhda A. Rozanova, Saltanat Serikbolkyzy, Andrei A Simonov, Valeriya V. Skachkova, Daria V. Soloveva, Irina A. Soloveva, Alexander K. Subbotin, Irina M. Sukhomlinova, Anastasiia G. Sushilova, Dilnoza R. Tagayeva, Yuliia V. Titojkina, Elena P. Tikhonova, Danil S. Tokmin, Anastasiia A. Tolmacheva, Mariya S. Torgunakova, Ksenia V. Trenogina, Natalia A. Trostianetckaia, Dmitriy A. Trofimov, Alexander A. Tulichev, Assiya T. Tursunova, Nina D. Ulanova, Oleg V. Fatenkov, Olga V. Fedorishina, Tatiana S. Fil, Irina Yu. Fomina, Irina S. Fominova, Irina A. Frolova, Svetlana M. Tsvinger, Vera V. Tsoma, Meerim B. Cholponbaeva, Tatiana I. Chudinovskikh, Olga A. Shevchenko, Tatyana V. Sheshina, Ekaterina A. Shishkina, Konstantin Yu. Shishkov, Stanislav Yu. Sherbakov, and Ekaterina A. Yausheva

Subjects
Adult, Male, Heart Failure, History, SARS-CoV-2, Endocrinology, Diabetes and Metabolism, COVID-19, Coronary Disease, General Medicine, Prognosis, Cardiovascular Diseases, Chronic Disease, Hypertension, Diabetes Mellitus, Humans, Female, Registries, Family Practice, Noncommunicable Diseases
Abstract

Study the impact of various combinations of comorbid original diseases in patients infected with COVID-19 later on the disease progression and outcomes of the new coronavirus infection.The ACTIV registry was created on the Eurasian Association of Therapists initiative. 5,808 patients have been included in the registry: men and women with COVID-19 treated at hospital or at home.gov ID NCT04492384.Most patients with COVID-19 have original comorbid diseases (oCDs). Polymorbidity assessed by way of simple counting of oCDs is an independent factor in negative outcomes of COVID-19. Search for most frequent combinations of 2, 3 and 4 oCDs has revealed absolute domination of cardiovascular diseases (all possible variants). The most unfavorable combination of 2 oCDs includes atrial hypertension (AH) and chronic heart failure (CHF). The most unfavorable combination of 3 oCDs includes AH, coronary heart disease (CHD) and CHF; the worst combination of 4 oCDs includes AH, CHD, CHF and diabetes mellitus. Such combinations increased the risk of lethal outcomes 3.963, 4.082 and 4.215 times respectively.Polymorbidity determined by way of simple counting of diseases may be estimated as a factor in the lethal outcome risk in the acute phase of COVID-19 in real practice. Most frequent combinations of 2, 3 and 4 diseases in patients with COVID-19 primarily include cardiovascular diseases (AH, CHD and CHF), diabetes mellitus and obesity. Combinations of such diseases increase the COVID-19 lethal outcome risk.Цель. Изучить влияние различных комбинаций сопутствующих заболеваний, существовавших у пациентов исходно, до инфицирования вирусом SARS-CoV-2, на тяжесть течения и исходы новой коронавирусной инфекции. Материалы и методы. Регистр АКТИВ создан по инициативе Евразийской ассоциации терапевтов. В регистр включены 5808 пациентов: мужчины и женщины с диагнозом COVID-19, находящиеся на лечении в стационаре или получающие лечение на дому. Регистрация регистра: идентификатор ClinicalTrials.gov: NCT04492384. Результаты. Подавляющее большинство пациентов с COVID-19 имеют исходные сопутствующие заболевания (иСЗ). Полиморбидность, оцененная методом простого подсчета иСЗ, является самостоятельным фактором негативного прогноза больных COVID-19. Поиск наиболее часто встречающихся комбинаций из 2, 3, 4 и более СЗ выявил абсолютное доминирование сердечно-сосудистых заболеваний во всех возможных вариантах. Наиболее неблагоприятной при сочетании 2 иСЗ была комбинация, включающая артериальную гипертензию (АГ) и хроническую сердечную недостаточность (ХСН), при сочетании 3 иСЗ комбинация, включающая АГ, ишемическую болезнь сердца (ИБС), ХСН, и при сочетании 4 иСЗ комбинация, включающая АГ, ИБС, ХСН и сахарный диабет. Наличие таких комбинаций приводило к росту риска летального исхода в 3,963, 4,082, 4,215 раза соответственно. Заключение. Полиморбидность, определенная методом простого подсчета заболеваний, может использоваться в реальной практике как фактор риска летальности в остром периоде COVID-19. В состав наиболее часто встречающихся комбинаций из 2, 3, 4 заболеваний у пациентов с COVID-19 входят преимущественно сердечно-сосудистые заболевания (АГ, ИБС, ХСН), сахарный диабет и ожирение. Комбинации этих заболеваний повышают риск летального исхода при COVID-19.

Published
2021

6. Analysis of influence of background therapy for comorbidities in the period before infection on the risk of the lethal COVID outcome. Data from the international ACTIV SARS-CoV-2 registry («Analysis of chronic non-infectious diseases dynamics after COVID-19 infection in adult patients SARS-CoV-2»)

Author

N V Lareva, A Sh Kerimova, D A Shсukarev, I. V. Fomin, I. A. Karetnikov, K. F. Kasymova, U. K. Kamilova, A. M. Budu, A O Konradi, A. A. Marusina, V. I. Majseenko, Yu D Zimina, E. V. Ponomarenko, E. V. Grigorieva, N. V. Bakulina, I. G. Pochinka, O. V. Kondriakova, N. A. Lyubavina, A. G. Sushilova, K. V. Protasov, E A Konstantinova, Yu. M. Lopatin, I I Shaposhnik, O. V. Karpov, I. A. Soloveva, N. V. Zarechnova, M. V. Bragin, G. T. Aimakhanova, O Yu Badina, O Yu Chizhova, A. P. Rebrov, D. V. Soloveva, E S Kim, V. I. Levankova, S. V. Malchikova, A. S. Galyavich, I. M. Sukhomlinova, M. B. Cholponbaeva, A. V. Klimova, A. R. Vaisberg, M. P. Konoval, V. V. Skachkova, N. N. Vezikova, E. A. Gаlova, N. A. Prokofeva, M Е Levin, L. A. Balykova, M. V. Kazakovtseva, A. S. Makarova, T. I. Chudinovskikh, K R Vagapova, A. K. Subbotin, N Yu Kurchugina, A. T. Tursunova, L. D. Petrov, O. R. Aruslanova, M V Ilina, Yu N Belenkov, I. V. Gubareva, E. S. Melnikov, G. A. Bykova, S Yu Ivanova, Yu V Titojkina, Z. F. Kim, A. V. Aparkina, D Yu Konstantinov, A. M. Maripov, K. V. Trenogina, Ch K. Kulchoroeva, E. A. Yausheva, S. S. Plastinina, N. D. Ulanova, D. D. Varlamova, E. V. Makarova, S. V. Nedogoda, R. V. Gostishev, A. P. Babin, A S Sarybaev, S. A. Avetisian, M. S. Torgunakova, G P Arutyunov, O. V. Fedorishina, L. V. Kurenkova, Sh O. Ospanova, G M Dabylova, E. I. Gorshenina, V V Genkel, N. M. Nikitina, M Kh Karsiev, R. G. Muradyan, M. V. Boldina, S Yu Sherbakov, A. A. Odegova, E. P. Tikhonova, M. I. Kolyadich, D. N. Protsenko, V. V. Gomonova, N. A. Karoli, T. V. Kuprina, N. B. Moiseenko, A O Myshak, K Yu Shishkov, N Yu Grigorieva, K. E. Egorova, A. N. Rakhimov, V. A. Pogrebetskaya, S. N. Tereshchenko, V. V. Vustina, I. U. Bikhteyev, N. A. Magdeyeva, Sh N. Musaelian, A. A. Tulichev, O. V. Khlynova, E. V. Kolmakova, A. I. Demchenko, E. V. Pahomova, I. A. Frolova, D. A. Trofimov, M. Y. Duyshobayev, A I Chesnikova, T. S. Fil, A. S. Kuznetsova, N. A. Kamardina, K. V. Kuzmichev, I. V. Demko, D. A. Klimenko, D. S. Evdokimov, O. E. Vilkova, K. V. Mazalov, A Ch Akunov, A. N. Ermilova, N. A. Rakov, B. B. Ogurlieva, O. V. Fatenkov, O. A. Shevchenko, A A Tolmacheva, E Yu Ashina, E. A. Vinnikova, D Yu Ruzanau, Zh B. Kerimbekova, A. K. Abdrahmanova, Yu S. Kalinina, T. V. Sheshina, I. G. Bakulin, Yu M. Omarova, A. V. Zharkov, I S Fominova, H. G. Hayrapetyan, L. A. Burygina, N. V. Kiseleva, A. M. Karachenova, A. M. Bitieva, D. S. Polyakov, T V Kriukova, F. M. Sokhova, A. G. Arutyunov, D. A. Ayipova, M. M. Petrova, M K Alieva, N. A. Borodulina, F. N. Muradova, I. A. Pudova, N A Kushubakova, A. A. Simonov, V. V. Tsoma, S. Serikbolkyzy, O Yu Barisheva, E. A. Shishkina, O. V. Kovalishena, L. L. Popova, A. V. Evzerikhina, A S Batchayeva, T Yu Kuzmina, K. K. Azarian, D. S. Tokmin, N. A. Omurzakova, D S Кaskaeva, A. E. Zheldybayeva, T. Yu. Kuznetsova, I Yu Fomina, E. A. Verbitskaya, N. A. Rozanova, D. R. Tagayeva, S. M. Tsvinger, E. Yu. Ivanchenko, S A Sayganov, N. A. Trostianetckaia, A. S. Blagonravova, A. Yu. Kraposhina, V. A. Kordukova, E. I. Tarlovskaya, O Yu Dolgikh, I. M. Kouranova, H. G. Avoyan, E. V. Kazymova, T. P. Kolchinskaya, N M Selezneva, A. B. Sugraliev, E. V. Koroleva, and E Yu Gubareva

Subjects
Adult, Male, medicine.medical_specialty, Population, Disease, Comorbidity, Lower risk, Pharmacotherapy, Internal medicine, medicine, Humans, Registries, education, Noncommunicable Diseases, Pandemics, education.field_of_study, COPD, business.industry, SARS-CoV-2, COVID-19, medicine.disease, Clopidogrel, Diabetes Mellitus, Type 2, Female, Cardiology and Cardiovascular Medicine, business, Ticagrelor, medicine.drug
Abstract

Aim To study the effect of regular drug therapy for cardiovascular and other diseases preceding the COVID-19 infection on severity and outcome of COVID-19 based on data of the ACTIVE (Analysis of dynamics of Comorbidities in paTIents who surVived SARS-CoV-2 infEction) registry.Material and methods The ACTIVE registry was created at the initiative of the Eurasian Association of Therapists. The registry includes 5 808 male and female patients diagnosed with COVID-19 treated in a hospital or at home with a due protection of patients’ privacy (data of nasal and throat smears; antibody titer; typical CT imaging features). The register territory included 7 countries: the Russian Federation, the Republic of Armenia, the Republic of Belarus, the Republic of Kazakhstan, the Kyrgyz Republic, the Republic of Moldova, and the Republic of Uzbekistan. The registry design: a closed, multicenter registry with two nonoverlapping arms (outpatient arm and in-patient arm). The registry scheduled 6 visits, 3 in-person visits during the acute period and 3 virtual visits (telephone calls) at 3, 6, and 12 mos. Patient enrollment started on June 29, 2020 and was completed on October 29, 2020. The registry completion is scheduled for October 29, 2022. The registry ID: ClinicalTrials.gov: NCT04492384. In this fragment of the study of registry data, the work group analyzed the effect of therapy for comorbidities at baseline on severity and outcomes of the novel coronavirus infection. The study population included only the patients who took their medicines on a regular basis while the comparison population consisted of noncompliant patients (irregular drug intake or not taking drugs at all despite indications for the treatment).ResultsThe analysis of the ACTIVE registry database included 5808 patients. The vast majority of patients with COVID-19 had comorbidities with prevalence of cardiovascular diseases. Medicines used for the treatment of COVID-19 comorbidities influenced the course of the infectious disease in different ways. A lower risk of fatal outcome was associated with the statin treatment in patients with ischemic heart disease (IHD); with angiotensin-converting enzyme inhibitors (ACEI)/angiotensin receptor antagonists and with beta-blockers in patients with IHD, arterial hypertension, chronic heart failure (CHF), and atrial fibrillation; with oral anticoagulants (OAC), primarily direct OAC, clopidogrel/prasugrel/ticagrelor in patients with IHD; with oral antihyperglycemic therapy in patients with type 2 diabetes mellitus (DM); and with long-acting insulins in patients with type 1 DM. A higher risk of fatal outcome was associated with the spironolactone treatment in patients with CHF and with inhaled corticosteroids (iCS) in patients with chronic obstructive pulmonary disease (COPD).Conclusion In the epoch of COVID-19 pandemic, a lower risk of severe course of the coronavirus infection was observed for patients with chronic noninfectious comorbidities highly compliant with the base treatment of the comorbidity.

Published
2021

7. [International register 'Analysis of Chronic Non-infectious Diseases Dynamics After COVID-19 Infection in Adult Patients (ACTIV SARS-CoV-2)']

Author

V. V. Tsoma, N A Krivosheina, M S Grigorovich, D. R. Tagayeva, D Y Ruzanau, A. M. Budu, A O Konradi, I Y Fomina, E. V. Kazymova, O. V. Kondriakova, I I Shaposhnik, M D Gaukhar, E. V. Grigorieva, N. N. Vezikova, I A Duvanov, I. A. Pudova, N. A. Prokofeva, G. T. Aimakhanova, D. A. Trofimov, E. S. Melnikov, L. D. Shakhgildyan, T. I. Chudinovskikh, M. V. Kazakovtseva, A. T. Tursunova, A. K. Abdrahmanova, A. B. Sugraliev, E. V. Koroleva, A. P. Rebrov, D. S. Evdokimov, S V Baramzina, E. P. Tikhonova, N. A. Magdeyeva, Y N Belenkov, T. Y. Kuzmina, A A Levchenko, L. A. Burygina, S T Fil, A S Kerimova, I. M. Kouranova, A. R. Vaisberg, M. P. Konoval, Z. F. Kim, A. V. Aparkina, A. A. Tulichev, D. S. Tokmin, I. V. Fomin, S. N. Tereshchenko, N. U. Grigorieva, D V Saphonov, N. A. Kamardina, R. V. Gostishev, U. K. Kamilova, L. A. Smirnova, O A Chumakova, H. G. Avoyan, N A Kushubakova, K. V. Mazalov, A. N. Ermilova, V V Genkel, N. A. Lyubavina, A E Gаlova, O. V. Fatenkov, Y M Lopatin, V. V. Gomonova, H. G. Hayrapetyan, N. V. Zarechnova, E S Kim, Z D Rasulova, N Y Kurchugina, S A Sayganov, N. M. Nikitina, T. V. Sheshina, G P Arutyunov, V. I. Levankova, S. V. Malchikova, A. A. Simonov, T. V. Kuprina, E Y Ashina, S. S. Plastinina, A S Sarybaev, N. A. Trostianetckaia, I. A. Frolova, S. V. Nedogoda, S. Serikbolkyzy, F. N. Muradova, M. B. Cholponbaeva, A. V. Evzerikhina, N. A. Rozanova, T Y Kuznetsova, A. S. Galyavich, A. A. Odegova, A C Akunov, D. I. Tupitsin, Y V Omarova, A. S. Blagonravova, A. K. Subbotin, O Y Barisheva, N. V. Kiseleva, A. V. Klimova, Sh O. Ospanova, M. E. Levin, M. Y. Duyshobayev, O. V. Kovalishena, V M Boldina, E. V. Makarova, Zh B. Kerimbekova, E Y Gubareva, D. V. Soloveva, D. N. Protsenko, N. A. Karoli, K. E. Egorova, A Y Kraposhina, V. A. Pogrebetskaya, K. K. Azarian, E. V. Pahomova, N V Zelyaeva, D. A. Ayipova, S. A. Avetisian, O Y Badina, R. G. Muradyan, I. V. Demko, V. A. Kordukova, E. I. Tarlovskaya, D Y Konstantinov, M. I. Kolyadich, A. E. Zheldybayeva, A. P. Babin, Sh N. Musaelian, D S Kaskaeva, S Y Chukhlova, K Y Shishkov, T. P. Kolchinskaya, T V Kriukova, I. V. Gubareva, O Y Dolgikh, V. I. Majseenko, O. V. Karpov, I. A. Soloveva, S Y Sherbakov, A. M. Bitieva, D. S. Polyakov, E M Mamutova, F. M. Sokhova, A. G. Arutyunov, L. D. Petrov, M. M. Petrova, S Y Ivanova, D. D. Varlamova, A. A. Tiurin, D A Doshchannikov, A. I. Demchenko, A I Chesnikova, A. S. Kuznetsova, D. A. Klimenko, and O. E. Vilkova

Subjects
Adult, 2019-20 coronavirus outbreak, Adult patients, Coronavirus disease 2019 (COVID-19), business.industry, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), MEDLINE, COVID-19, Virology, Medicine, Humans, Cardiology and Cardiovascular Medicine, business, Noncommunicable Diseases, Non infectious
Published
2021

8. Lanthanum and cerium separation on sulfonic cation-exchanger purolite C-160

Author

E. V. Kirillov, A. K. Abdrahmanova, S. M. Titova, V. N. Rychkov, A. S. Malyshev, and O. V. Yakovleva

Subjects
inorganic chemicals, chemistry.chemical_compound, Cerium, Column chromatography, chemistry, Ion exchange, Inorganic chemistry, Lanthanum, chemistry.chemical_element, Sulfuric acid, Capacity value, Saturation (chemistry), Ion-exchange resin
Abstract

The possibility of using Purolite C-160 ion exchange resin for separation of La and Ce by the method of size-exclusion chromatography was studied. The saturation of the resin in NH4+ form should be carried out from sulfuric acid solutions at pH 2.5. The exchange capacity value of the resin at full saturation was 35.82 kg La/m3 and 38.37 kg Ce/m3. The chromatography could be carried out by use of Fe3+ as ion-moderator and EDTA solution as eluent (0.015 M, pH 8.0).

Published
2020

9. ACTIV SARS-CoV-2 registry (Analysis of Chronic Non-infectious Diseases Dynamics After COVID-19 Infection in Adult Patients). Assessment of impact of combined original comorbid diseases in patients with COVID-19 on the prognosis

Author

Gregory P. Arutyunov, Ekaterina I. Tarlovskaya, Alexander G. Arutyunov, Yuri N. Belenkov, Alexandra O. Konradi, Yury M. Lopatin, Andrey P. Rebrov, Sergey N. Tereshchenko, Anna I. Chesnikova, Hamlet G. Hayrapetyan, Aleksandr P. Babin, Igor G. Bakulin, Natalia V. Bakulina, Larisa A. Balykova, Anna S. Blagonravova, Marina V. Boldina, Alexandra R. Vaisberg, Albert S. Galyavich, Veronika V. Gomonova, Natalia Yu. Grigorieva, Irina V. Gubareva, Irina V. Demko, Angelika V. Evzerikhina, Aleksandr V. Zharkov, Umida K. Kamilova, Zulfia F. Kim, Tatiana Yu. Kuznetsova, Natalia V. Lareva, Ekaterina V. Makarova, Svetlana V. Malchikova, Sergey V. Nedogoda, Marina M. Petrova, Ilya G. Pochinka, Konstantin V. Protasov, Denis N. Protsenko, Dmitry Yu. Ruzanau, Sergey A. Sayganov, Akpay S. Sarybaev, Natalia M. Selezneva, Akhmetzhan B. Sugraliev, Igor V. Fomin, Olga V. Khlynova, Olga Yu. Chizhova, Igor I. Shaposhnik, Dmitry A. Sh'ukarev, Айгуль K. Abdrahmanova, Susanna A. Avetisian, Hovhannes G. Avoyan, Karine K. Azarian, Galiya T. Aimakhanova, Dinara A. Ayipova, Almazbek Ch. Akunov, Marianna K. Alieva, Aliona V. Aparkina, Olga R. Aruslanova, Ekaterina Yu. Ashina, Olga Yu. Badina, Olga Yu. Barisheva, Alina S. Batchayeva, Anna M. Bitieva, Ismail U. Bikhteyev, Nataliya A. Borodulina, Maksim V. Bragin, Angela M. Budu, Galina M. Bykova, Kristina R. Vagapova, Darina D. Varlamova, Natalia N. Vezikova, Elena A. Verbitskaya, Olga E. Vilkova, Elena A. Vinnikova, Vera V. Vustina, Elena A. Galova, Vadim V. Genkel, Elena I. Gorshenina, Roman V. Gostishev, Elena V. Grigorieva, Ekaterina Yu. Gubareva, Gaukhar M. Dabylova, Anastasiya I. Demchenko, Oleg Yu. Dolgikh, Melis Y. Duyshobayev, Dmitrii S. Evdokimov, Ksenia E. Egorova, Anastasiia N. Ermilova, Aliya E. Zheldybayeva, Nataliya V. Zarechnova, Yuliia D. Zimina, Svetlana Yu. Ivanova, Elena Yu. Ivanchenko, Mariya V. Ilina, Maria V. Kazakovtseva, Elena V. Kazymova, Yuliya S. Kalinina, Nadezhda A. Kamardina, Anastasiya M. Karachenova, Igor A. Karetnikov, Nina A. Karoli, Magomed Kh. Karsiev, Daria S. Кaskaeva, Karina F. Kasymova, Zhainagul B. Kerimbekova, Ailar Sh. Kerimova, Eugeni S. Kim, Nina V. Kiseleva, Darya A. Klimenko, Anastasiia V. Klimova, Olga V. Kovalishena, Elena V. Kolmakova, Tatyana P. Kolchinskaya, Maria I. Kolyadich, Olga V. Kondriakova, Marina P. Konoval, Dmitryi Yu. Konstantinov, Elena A. Konstantinova, Vera A. Kordukova, Ekaterina V. Koroleva, Angelina Yu. Kraposhina, Tamara V. Kriukova, Alla S. Kuznetsova, Tatyana Yu. Kuzmina, Kirill V. Kuzmichev, Cholpon K. Kulchoroevna, Tatiana V. Kuprina, Irina M. Kouranova, Liliya V. Kurenkova, Natalia Yu. Kurchugina, Nadira A. Kushubakova, Valeriia I. Levankova, Natalia A. Lyubavina, Nadezhda A. Magdeyeva, Konstantin V. Mazalov, Viktoryia I. Majseenko, Aleksandra S. Makarova, Abdirashit M. Maripov, Anastasiia A. Marusina, Evgenii S. Melnikov, Nikita B. Moiseenko, Fazliniso N. Muradova, Rimma G. Muradyan, Shahane N. Musaelian, Anton O. Myshak, Ekaterina S. Nekaeva, Nataliia M. Nikitina, Bela B. Ogurlieva, Alla A. Odegova, Yuliia V. Omarova, Nazgul A. Omurzakova, Shynar O. Ospanova, Ekaterina V. Pahomova, Liviu D. Petrov, Svetlana S. Plastinina, Vera A. Pogrebetskaya, Dmitry S. Polyakov, Ekaterina V. Ponomarenko, Larisa L. Popova, Natalya A. Prokofeva, Inna A. Pudova, Nikita A. Rakov, Abdurakhmon N. Rahimov, Nadezhda A. Rozanova, Saltanat Serikbolkyzy, Andrei A Simonov, Valeriya V. Skachkova, Daria V. Soloveva, Irina A. Soloveva, Alexander K. Subbotin, Irina M. Sukhomlinova, Anastasiia G. Sushilova, Dilnoza R. Tagayeva, Yuliia V. Titojkina, Elena P. Tikhonova, Danil S. Tokmin, Anastasiia A. Tolmacheva, Mariya S. Torgunakova, Ksenia V. Trenogina, Natalia A. Trostianetckaia, Dmitriy A. Trofimov, Alexander A. Tulichev, Assiya T. Tursunova, Nina D. Ulanova, Oleg V. Fatenkov, Olga V. Fedorishina, Tatiana S. Fil, Irina Yu. Fomina, Irina S. Fominova, Irina A. Frolova, Svetlana M. Tsvinger, Vera V. Tsoma, Meerim B. Cholponbaeva, Tatiana I. Chudinovskikh, Olga A. Shevchenko, Tatyana V. Sheshina, Ekaterina A. Shishkina, Konstantin Yu. Shishkov, Stanislav Yu. Sherbakov, and Ekaterina A. Yausheva

Subjects
covid-19, activ registry, cardiovascular diseases, diabetes mellitus, polymorbidity, disease combinations, Medicine
Abstract

Aim. Study the impact of various combinations of comorbid original diseases in patients infected with COVID-19 later on the disease progression and outcomes of the new coronavirus infection. Materials and methods. The ACTIV registry was created on the Eurasian Association of Therapists initiative. 5,808 patients have been included in the registry: men and women with COVID-19 treated at hospital or at home. ClinicalTrials.gov ID NCT04492384. Results. Most patients with COVID-19 have original comorbid diseases (oCDs). Polymorbidity assessed by way of simple counting of oCDs is an independent factor in negative outcomes of COVID-19. Search for most frequent combinations of 2, 3 and 4 oCDs has revealed absolute domination of cardiovascular diseases (all possible variants). The most unfavorable combination of 2 oCDs includes atrial hypertension (AH) and chronic heart failure (CHF). The most unfavorable combination of 3 oCDs includes AH, coronary heart disease (CHD) and CHF; the worst combination of 4 oCDs includes AH, CHD, CHF and diabetes mellitus. Such combinations increased the risk of lethal outcomes 3.963, 4.082 and 4.215 times respectively. Conclusion. Polymorbidity determined by way of simple counting of diseases may be estimated as a factor in the lethal outcome risk in the acute phase of COVID-19 in real practice. Most frequent combinations of 2, 3 and 4 diseases in patients with COVID-19 primarily include cardiovascular diseases (AH, CHD and CHF), diabetes mellitus and obesity. Combinations of such diseases increase the COVID-19 lethal outcome risk.

Published
2022
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