1. Chromobacterium biopesticide overcomes insecticide resistance in malaria vector mosquitoes.
- Author
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Tikhe, Chinmay, Issiaka, Sare, Dong, Yuemei, Kefi, Mary, Tavadia, Mihra, Bilgo, Etienne, Corder, Rodrigo, Marshall, John, Diabate, Abdoulaye, and Dimopoulos, George
- Subjects
Animals ,Insecticide Resistance ,Mosquito Vectors ,Malaria ,Chromobacterium ,Anopheles ,Insecticides ,Mosquito Control ,Biological Control Agents ,Burkina Faso ,Pest Control ,Biological - Abstract
Vector mosquito control is an integral part of malaria control. The global emergence of insecticide resistance in malaria-transmitting Anophelines has become an impediment and has created an urgent need for novel mosquito control approaches. Here, we show that a biopesticide derived from the soil-dwelling bacterium Chromobacterium sp. Panama (Csp_P) kills insecticide-resistant Anopheles mosquitoes, regardless of their resistance mechanisms. In addition, sublethal dose of Csp_P acts as a synergist to now used chemical insecticides across multiple classes. Moreover, Csp_P reduces host-seeking behavior and malaria parasite infection in vector mosquitoes in ways that further decrease transmission. Mosquito glutathione S-transferases are essential for Csp_Ps mosquito-killing mechanism. Enclosed field trials in Burkina Faso, conducted in diverse ecological settings and supported by a mathematical model, have now demonstrated its potential for malaria control in settings with widespread insecticide resistance.
- Published
- 2024