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4,132 results on '"A. Khudyakov"'

1. The upper limit on the $K^+ \to \pi^0\pi^0\pi^0e^+\nu$ decay

Author

Kulik, A. V., Filippov, S. N., Gushchin, E. N., Khudyakov, A. A., Kravtsov, V. I., Kudenko, Yu. G., Polyarush, A. Yu., Artamonov, A. V., Donskov, S. V., Filin, A. P., Gorin, A. M., Inyakin, A. V., Khaustov, G. V., Kholodenko, S. A., Kolosov, V. N., Konoplyannikov, A. K., Kurshetsov, V. F., Lishin, V. A., Medynsky, M. V., Obraztsov, V. F., Okhotnikov, A. V., Polyakov, V. A., Romanovsky, V. I., Rykalin, V. I., Sadovsky, A. S., Samoylenko, V. D., Tiurin, I. S., Uvarov, V. A., and Yushchenko, O. P.

Subjects
High Energy Physics - Experiment
Abstract

A search for the $K^{+} \to \pi^{0}\pi^{0}\pi^{0}e^+\nu$ decay is performed by the OKA collaboration. The search is based on $3.65 \times 10^9 ~ K^+$ decays. No signal is observed. The upper limit set is $BR(K^{+} \to \pi^{0}\pi^{0}\pi^{0}e^+\nu) < 5.4\times 10^{-8} ~ 90\%$ CL, 65 times lower than the one currently listed by PDG.

Published
2024

3. The Upper Limit on the K+ → π0π0π0e+ν Decay

Author

Artamonov, A. V., Bychkov, V. N., Donskov, S. V., Filin, A. P., Filippov, S. N., Gorin, A. M., Gushchin, E. N., Inyakin, A. V., Kekelidze, G. D., Khaustov, G. V., Kholodenko, S. A., Khudyakov, A. A., Kolosov, V. N., Konoplyannikov, A. K., Kravtsov, V. I., Kudenko, Yu. G., Kulik, A. V., Kurshetsov, V. F., Lishin, V. A., Lysan, V. M., Medynsky, M. V., Obraztsov, V. F., Okhotnikov, A. V., Polyakov, V. A., Polyarush, A. Yu., Romanovsky, V. I., Rykalin, V. I., Sadovsky, A. S., Samoylenko, V. D., Shapkin, M. M., Tiurin, I. S., Uvarov, V. A., Yushchenko, O. P., and Zalikhanov, B. Zh.

Published
2024
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4. Tool-Augmented LLMs as a Universal Interface for IDEs

Author

Zharov, Yaroslav, Khudyakov, Yury, Fedotova, Evgeniia, Grigorenko, Evgeny, and Bogomolov, Egor

Subjects
Computer Science - Software Engineering
Abstract

Modern-day Integrated Development Environments (IDEs) have come a long way from the early text editing utilities to the complex programs encompassing thousands of functions to help developers. However, with the increasing number of efficiency-enhancing tools incorporated, IDEs gradually became sophisticated software with a steep learning curve. The rise of the Large Language Models (LLMs) capable of both natural language dialogue and code generation leads to a discourse on the obsolescence of the concept of IDE. In this work, we offer a view on the place of the LLMs in the IDEs as the universal interface wrapping the IDE facilities. We envision a model that is able to perform complex actions involving multiple IDE features upon user command, stripping the user experience of the tedious work involved in searching through options and actions. For the practical part of the work, we engage with the works exploring the ability of LLMs to call for external tools to expedite a given task execution. We showcase a proof-of-concept of such a tool., Comment: First IDE Workshop, ICSE'24

Published
2024
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6. Observation of $K^{+} \to \pi^{+}\pi^{0}\pi^{0}\gamma$ decay

Author

Filippov, S. N., Gushchin, E. N., Khudyakov, A. A., Kravtsov, V. I., Kudenko, Yu G., Kulik, A. V., Polyarush, A. Yu., Artamonov, A. V., Donskov, S. V., Filin, A. P., Gorin, A. M., Inyakin, A. V., Khaustov, G. V., Kholodenko, S. A., Kolosov, V. N., Kurshetsov, V. F., Lishin, V. A., Medynsky, M. V., Obraztsov, V. F., Okhotnikov, A. V., Polyakov, V. A., Romanovsky, V. I., Rykalin, V. I., Sadovsky, A. S., Samoylenko, V. D., Tiurin, I. S., Uvarov, V. A., Yushchenko, O. P., Bychkov, V. N., Kekelidze, G. D., Lysan, V. M., and Zalikhanov, B. Zh.

Subjects
High Energy Physics - Experiment
Abstract

The $K^{+} \to \pi^{+}\pi^{0}\pi^{0}\gamma$ decay is observed by the OKA collaboration. The branching ratio is measured to be $(4.1 \pm 0.9(stat) \pm 0.4(syst))\times 10^{-6}$. The branching ratio and $\gamma$ energy spectrum are consistent with ChPT prediction., Comment: arXiv admin note: text overlap with arXiv:2310.16429

Published
2023

7. Searches for the light invisible axion-like particle in $K^{+}\to\pi^{+}\pi^{0}a$ decay

Author

Sadovsky, A. S., Filin, A. P., Akimenko, S. A., Artamonov, A. V., Blik, A. M., Donskov, S. V., Gorin, A. M., Inyakin, A. V., Khaustov, G. V., Kholodenko, S. A., Kolosov, V. N., Kurshetsov, V. F., Lishin, V. A., Medynsky, M. V., Obraztsov, V. F., Okhotnikov, A. V., Polyakov, V. A., Romanovsky, V. I., Rykalin, V. I., Samoylenko, V. D., Tiurin, I. S., Uvarov, V. A., Yushchenko, O. P., Filippov, S. N., Gushchin, E. N., Khudyakov, A. A., Kravtsov, V. I., Kudenko, Yu G., Kulik, A. V., Polyarush, A. Yu., Bychkov, V. N., Kekelidze, G. D., Lysan, V. M., and Zalikhanov, B. Zh.

Subjects
High Energy Physics - Experiment
Abstract

A high statistics data sample of the $K^{+}$ decays is recorded by the OKA collaboration. A missing mass analysis is performed to search for a light invisible pseudoscalar axion-like particle (ALP) $a$ in the decay $K^{+} \to \pi^{+} \pi^{0} a$. No signal is observed, the upper limits for the branching ratio of the decay are calculated. The $90\%$ confidence level upper limit is changing from $2.5\cdot10^{-6}$ to $2\cdot10^{-7}$ for the ALP mass from 0 to 200 MeV/$c^{2}$, except for the region of $\pi^{0}$ mass, where the upper limit is $4.4\cdot10^{-6}$., Comment: 6 pages, 6 figures

Published
2023
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9. Magnetic shielding for large photoelectron multipliers for the OSIRIS facility of the JUNO detector

Author

Smirnov, O., Korablev, D., Sotnikov, A., Stahl, A., Steinmann, J., Khudyakov, V., Avetissov, I., and Zykova, M.

Subjects
Physics - Instrumentation and Detectors
Abstract

We present the technical design and characteristics of the magnetic shield developed for 20" PMTs of the low-background OSIRIS facility. A ribbon of amorphous alloy with the extreme magnetic permeability was used in its design providing the excellent efficiency in screening the Earth's magnetic field with a relatively small amount of the material. The mass of materials is crucial for the construction of low-background facilities from the point of view of radioactive backgrounds. Using amorphous materials is cost-efficient compared to other methods for screening the Earth's magnetic field., Comment: 15 pages, 8 figures, 5 tables

Published
2022
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10. Measurement of T-odd asymmetry in radiative K+ -> pi0 e+ nu gamma decay using OKA detector

Author

Polyarush, A. Yu., Akimenko, S. A., Artamonov, A. V., Bychkov, V. N., Donskov, S. V., Duka, V. A., Inyakin, A. V., Gorin, A. M., Gushchin, E. N., Filin, A. P., Filippov, S. N., Kekelidze, G. D., Kolosov, V. N., Kravtsov, V. I., Khaustov, G. V., Kholodenko, S. A., Khudyakov, A. A., Kudenko, Yu. G., Kulik, A. V., Kurshetsov, V. F., Lishin, V. A., Lysan, V. M., Medynsky, M. V., Obraztsov, V. F., Ohotnikov, A. V., Polyakov, V. A., Romanovsky, V. I., Rykalin, V. I., Sadovsky, A. S., Samoilenko, V. D., Tyurin, I. S., Tchikilev, O. G., Uvarov, V. A., Yushchenko, O. P., and Zalikhanov, B. Zh.

Subjects
High Energy Physics - Experiment
Abstract

The paper presents a measurement of the T-odd correlation in radiation decay \boldmath $K^+ \rightarrow \pi^{0} e^{+} \nu_{e} \gamma $ performed on the installation of the 101200 candidate events of the investigated decay were identified. Measured correlation $\xi_{\pi e \gamma}$ -is a mixed product of moments $e^{+}$, $\pi^{0}$, $\gamma$ in the kaon rest system, normalized by $M^{3}_{K}$. To assess the asymmetry of the distribution by $\xi_{\pi e \gamma}$ the value used is $A_{\xi}= \frac {N_{+}-N_{-}} {N_{+}+N_{-}}$, where $N_{+(-)}$ is the number of events with $\xi$ greater than (less than) zero. For the $A_{\xi}$ asymmetry, the value is obtained $A_{\xi} = (+0.1 \pm 3.9($stat.$) \pm1.7($syst.$))\times10^{-3}$ or $|A_{\xi}| < 5.4\times10^{-3} (90\%~ CL)$

Published
2022
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15. Observation of K+→π+π0π0γ decay

Author

Artamonov, A. V., Bychkov, V. N., Donskov, S. V., Filin, A. P., Filippov, S. N., Gorin, A. M., Gushchin, E. N., Inyakin, A. V., Kekelidze, G. D., Khaustov, G. V., Kholodenko, S. A., Khudyakov, A. A., Kolosov, V. N., Kravtsov, V. I., Kudenko, Yu. G., Kulik, A. V., Kurshetsov, V. F., Lishin, V. A., Lysan, V. M., Medynsky, M. V., Obraztsov, V. F., Okhotnikov, A. V., Polyakov, V. A., Polyarush, A. Yu., Romanovsky, V. I., Rykalin, V. I., Sadovsky, A. S., Samoylenko, V. D., Shapkin, M. M., Tiurin, I. S., Uvarov, V. A., Yushchenko, O. P., and Zalikhanov, B. Zh.

Published
2024
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16. Searches for the light invisible axion-like particle in K+→π+π0a decay

Author

Sadovsky, A. S., Filin, A. P., Akimenko, S. A., Artamonov, A. V., Blik, A. M., Bychkov, V. N., Donskov, S. V., Filippov, S. N., Gorin, A. M., Gushchin, E. N., Inyakin, A. V., Kekelidze, G. D., Khaustov, G. V., Kholodenko, S. A., Khudyakov, A. A., Kolosov, V. N., Kravtsov, V. I., Kudenko, Yu. G., Kulik, A. V., Kurshetsov, V. F., Lishin, V. A., Lysan, V. M., Medynsky, M. V., Obraztsov, V. F., Okhotnikov, A. V., Polyakov, V. A., Polyarush, A. Yu., Romanovsky, V. I., Rykalin, V. I., Samoylenko, V. D., Tiurin, I. S., Uvarov, V. A., Yushchenko, O. P., and Zalikhanov, B. Zh.

Published
2024
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21. Analysis of Proton Bunch Parameters in the AWAKE Experiment

Author

Hafych, V., Caldwell, A., Agnello, R., Ahdida, C. C., Aladi, M., Goncalves, M. C. Amoedo, Andrebe, Y., Apsimon, O., Apsimon, R., Bachmann, A. -M., Baistrukov, M. A., Batsch, F., Bergamaschi, M., Blanchard, P., Burrows, P. N., Buttenschön, B., Chappell, J., Chevallay, E., Chung, M., Cooke, D. A., Damerau, H., Davut, C., Demeter, G., Dexter, A., Doebert, S., Farmer, J., Fasoli, A., Fedosseev, V. N., Fiorito, R., Fonseca, R. A., Furno, I., Gessner, S., Gorn, A. A., Granados, E., Granetzny, M., Graubner, T., Grulke, O., Gschwendtner, E., Guran, E. D., Henderson, J. R., Hüther, M., Kedves, M. Á., Khudyakov, V., Kim, S. -Y., Kraus, F., Krupa, M., Lefevre, T., Liang, L., Lopes, N., Lotov, K. V., Mazzoni, S., Godoy, D. Medina, Moody, J. T., Moon, K., Guzmán, P. I. Morales, Moreira, M., Nechaeva, T., Nowak, E., Pakuza, C., Panuganti, H., Pardons, A., Perera, A., Pucek, J., Pukhov, A., Ráczkevi, B., Ramjiawan, R. L., Rey, S., Schmitz, O., Senes, E., Silva, L. O., Stollberg, C., Sublet, A., Topaloudis, A., Torrado, N., Tuev, P. V., Turner, M., Velotti, F., Verra, L., Vieira, J., Vincke, H., Welsch, C. P., Wendt, M., Wing, M., Wolfenden, J., Woolley, B., Xia, G., Zepp, M., and Della Porta, G. Zevi

Subjects
Physics - Accelerator Physics, High Energy Physics - Experiment
Abstract

A precise characterization of the incoming proton bunch parameters is required to accurately simulate the self-modulation process in the Advanced Wakefield Experiment (AWAKE). This paper presents an analysis of the parameters of the incoming proton bunches used in the later stages of the AWAKE Run 1 data-taking period. The transverse structure of the bunch is observed at multiple positions along the beamline using scintillating or optical transition radiation screens. The parameters of a model that describes the bunch transverse dimensions and divergence are fitted to represent the observed data using Bayesian inference. The analysis is tested on simulated data and then applied to the experimental data.

Published
2021
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22. Simulation and Experimental Study of Proton Bunch Self-Modulation in Plasma with Linear Density Gradients

Author

Guzmán, P. I. Morales, Muggli, P., Agnello, R., Ahdida, C. C., Aladi, M., Goncalves, M. C. Amoedo, Andrebe, Y., Apsimon, O., Apsimon, R., Bachmann, A. -M., Baistrukov, M. A., Batsch, F., Bergamaschi, M., Blanchard, P., Braunmüller, F., Burrows, P. N., Buttenschön, B., Caldwell, A., Chappell, J., Chevallay, E., Chung, M., Cooke, D. A., Damerau, H., Davut, C., Demeter, G., Dexter, A., Doebert, S., Farmer, J., Fasoli, A., Fedosseev, V. N., Fiorito, R., Fonseca, R. A., Furno, I., Gessner, S., Gorn, A. A., Granados, E., Granetzny, M., Graubner, T., Grulke, O., Gschwendtner, E., Guran, E. D., Hafych, V., Henderson, J. R., Hüther, M., Kedves, M. Á., Khudyakov, V., Kim, S. -Y., Kraus, F., Krupa, M., Lefevre, T., Liang, L., Lopes, N., Lotov, K. V., Martyanov, M., Mazzoni, S., Godoy, D. Medina, Moody, J. T., Moon, K., Moreira, M., Nechaeva, T., Nowak, E., Pakuza, C., Panuganti, H., Pardons, A., Perera, A., Pucek, J., Pukhov, A., Ráczkevi, B., Ramjiawan, R. L., Rey, S., Schmitz, O., Senes, E., Silva, L. O., Stollberg, C., Sublet, A., Topaloudis, A., Torrado, N., Tuev, P. V., Turner, M., Velotti, F., Verra, L., Vieira, J., Vincke, H., Welsch, C. P., Wendt, M., Wing, M., Wolfenden, J., Woolley, B., Xia, G., Zepp, M., and Della Porta, G. Zevi

Subjects
Physics - Plasma Physics, Physics - Accelerator Physics
Abstract

We present numerical simulations and experimental results of the self-modulation of a long proton bunch in a plasma with linear density gradients along the beam path. Simulation results agree with the experimental results reported in arXiv:2007.14894v2: with negative gradients, the charge of the modulated bunch is lower than with positive gradients. In addition, the bunch modulation frequency varies with gradient. Simulation results show that dephasing of the wakefields with respect to the relativistic protons along the plasma is the main cause for the loss of charge. The study of the modulation frequency reveals details about the evolution of the self-modulation process along the plasma. In particular for negative gradients, the modulation frequency across time-resolved images of the bunch indicates the position along the plasma where protons leave the wakefields. Simulations and experimental results are in excellent agreement., Comment: 13 pages, 11 figures

Published
2021
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24. Comprehensive molecular and morphological resolution of blubber stratification in a deep-diving, fasting-adapted seal

Author

Khudyakov, JI, Allen, KN, Crocker, DE, Trost, NS, Roberts, AH, Pirard, L, Debier, C, Piotrowski, ER, and Vázquez-Medina, JP

Subjects
Affordable and Clean Energy, blubber depth, transcriptome, histology, seal, metabolism and endocrinology, adipogenesis, Physiology, Medical Physiology, Psychology
Abstract

Blubber is a modified subcutaneous adipose tissue in marine mammals that provides energy storage, thermoregulation, hydrodynamic locomotion, and buoyancy. Blubber displays vertical stratification by lipid content, fatty acid composition, and vascularization, leading to the assumption that deeper blubber layers are metabolically active, while superficial layers are mainly structural and thermoregulatory. However, few studies have examined functional stratification of marine mammal blubber directly, especially in pinnipeds. We characterized morphological and transcriptional differences across blubber layers in the northern elephant seal, a deep-diving and fasting-adapted phocid. We collected blubber from seals early in their fasting period and divided blubber cores into three similarly sized portions. We hypothesized that the innermost blubber portion would have higher 1) heterogeneity in adipocyte size, 2) microvascular density, and 3) expression of genes associated with metabolism and hormone signaling than outer blubber. We found that adipocyte area and variance increased from outermost (skin-adjacent) to innermost (muscle-adjacent) blubber layers, suggesting that inner blubber has a higher capacity for lipid storage and turnover than outer blubber. Inner blubber had a higher proportion of CD144+ endothelial cells, suggesting higher microvascular density. In contrast, outer blubber had a higher proportion of CD4+ immune cells than inner blubber, suggesting higher capacity for response to tissue injury. Transcriptome analysis identified 61 genes that were differentially expressed between inner and outer blubber layers, many of which have not been studied previously in marine mammals. Based on known functions of these genes in other mammals, we suggest that inner blubber has potentially higher 1) adipogenic capacity, 2) cellular diversity, and 3) metabolic and neuroendocrine signaling activity, while outer blubber may have higher 1) extracellular matrix synthesis activity and 2) responsiveness to pathogens and cell stressors. We further characterized expression of nine genes of interest identified by transcriptomics and two adipokines with higher precision across blubber layers using targeted assays. Our study provides functional insights into stratification of blubber in marine mammals and a molecular key, including CD144, CD4, HMGCS2, GABRG2, HCAR2, and COL1A2, for distinguishing blubber layers for physiological and functional studies in seals.

Published
2022

25. Time Domains of Hypoxia Responses and -Omics Insights.

Author

Yu, James J, Non, Amy L, Heinrich, Erica C, Gu, Wanjun, Alcock, Joe, Moya, Esteban A, Lawrence, Elijah S, Tift, Michael S, O'Brien, Katie A, Storz, Jay F, Signore, Anthony V, Khudyakov, Jane I, Milsom, William K, Wilson, Sean M, Beall, Cynthia M, Villafuerte, Francisco C, Stobdan, Tsering, Julian, Colleen G, Moore, Lorna G, Fuster, Mark M, Stokes, Jennifer A, Milner, Richard, West, John B, Zhang, Jiao, Shyy, John Y, Childebayeva, Ainash, Vázquez-Medina, José Pablo, Pham, Luu V, Mesarwi, Omar A, Hall, James E, Cheviron, Zachary A, Sieker, Jeremy, Blood, Arlin B, Yuan, Jason X, Scott, Graham R, Rana, Brinda K, Ponganis, Paul J, Malhotra, Atul, Powell, Frank L, and Simonson, Tatum S

Subjects
adaptation, high altitude, hypoxia, integrative physiology, oxygen, Lung, Sleep Research, Perinatal Period - Conditions Originating in Perinatal Period, Pediatric, Generic health relevance, Physiology, Medical Physiology, Psychology
Abstract

The ability to respond rapidly to changes in oxygen tension is critical for many forms of life. Challenges to oxygen homeostasis, specifically in the contexts of evolutionary biology and biomedicine, provide important insights into mechanisms of hypoxia adaptation and tolerance. Here we synthesize findings across varying time domains of hypoxia in terms of oxygen delivery, ranging from early animal to modern human evolution and examine the potential impacts of environmental and clinical challenges through emerging multi-omics approaches. We discuss how diverse animal species have adapted to hypoxic environments, how humans vary in their responses to hypoxia (i.e., in the context of high-altitude exposure, cardiopulmonary disease, and sleep apnea), and how findings from each of these fields inform the other and lead to promising new directions in basic and clinical hypoxia research.

Published
2022

26. Vitamin D supplements for fracture prevention in schoolchildren in Mongolia: analysis of secondary outcomes from a multicentre, double-blind, randomised, placebo-controlled trial

Author

Ganmaa, Davaasambuu, Khudyakov, Polyna, Buyanjargal, Uyanga, Tserenkhuu, Enkhtsetseg, Erdenenbaatar, Sumiya, Achtai, Chuluun-Erdene, Yansanjav, Narankhuu, Delgererekh, Baigal, Ankhbat, Munkhzaya, Tsendjav, Enkhjargal, Ochirbat, Batbayar, Jargalsaikhan, Badamtsetseg, Enkhmaa, Davaasambuu, and Martineau, Adrian R

Published
2024
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30. Study of $K^+ \rightarrow \pi^{0} e^{+} \nu \gamma $ decay with OKA setup

Author

Polyarush, A. Yu., Duk, V. A., Filippov, S. N., Guschin, E. N., Khudyakov, A. A., Kravtsov, V. I., Kudenko, Yu. G., Akimenko, S. A., Artamonov, A. V., Blik, A. M., Burtovoy, V. S., Donskov, S. V., Filin, A. P., Inyakin, A. V., Gorin, A. M., Khaustov, G. V., Kholodenko, S. A., Kolosov, V. N., Kurshetsov, V. F., Lishin, V. A., Medynsky, M. V., Mikhailov, Yu. V., Obraztsov, V. F., Polyakov, V. A., Romanovsky, V. I., Rykalin, V. I., Sadovsky, A. S., Samoilenko, V. D., Shapkin, M. M., Stenyakin, O. V., Tchikilev, O. G., Uvarov, V. A., Yushchenko, O. P., Bychkov, V. N., Kekelidze, G. D., Lysan, V. M., and Zalikhanov, B. Zh.

Subjects
High Energy Physics - Experiment
Abstract

Results of a study of the $K^+ \rightarrow \pi^{0} e^{+} \nu \gamma $ decay at OKA setup are presented. More than 32000 events of this decay are observed. The differential spectra over the photon energy and the photon-electron opening angle in kaon rest frame are presented. The branching ratios, normalized to that of $K_{e3}$ decay are calculated for different cuts in $E^*_\gamma$ and $cos\Theta^{*}_{e\gamma}$. In particular, the branching ratio for $E^{*}_{\gamma}>30$ MeV and $\Theta^{*}_{e \gamma}>20^{\circ}$ is measured R = $\frac{Br(K^+ \rightarrow \pi^{0} e^{+} \nu_{e} \gamma) } {Br(K^+ \rightarrow \pi^{0} e^{+} \nu_{e})} $ = =(0.587$\pm$0.010($stat.$)$\pm$0.015($syst.$))$\times10^{-2}$, which is in a good agreement with ChPT $O(p^{4})$ calculations.

Published
2020
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31. Dissipation of electron-beam-driven plasma wakes

Author

Zgadzaj, Rafal, Li, Zhengyan, Downer, M. C., Sosedkin, A., Khudyakov, V. K., Lotov, K. V., Silva, T., Vieira, J., Allen, J., Gessner, S., Hogan, M. J., Litos, M., and Yakimenko, V.

Subjects
Physics - Plasma Physics
Abstract

Metre-scale plasma wakefield accelerators have imparted energy gain approaching 10 gigaelectronvolts to single nano-Coulomb electron bunches. To reach useful average currents, however, the enormous energy density that the driver deposits into the wake must be removed efficiently between shots. Yet mechanisms by which wakes dissipate their energy into surrounding plasma remain poorly understood. Here, we report ps-time-resolved, grazing-angle optical shadowgraphic measurements and large-scale particle-in-cell simulations of ion channels emerging from broken wakes that electron bunches from the SLAC linac generate in tenuous lithium plasma. Measurements show the channel boundary expands radially at 1 million metres-per-second for over a nanosecond. Simulations show that ions and electrons that the original wake propels outward, carrying 90 percent of its energy, drive this expansion by impact-ionizing surrounding neutral lithium. The results provide a basis for understanding global thermodynamics of multi-GeV plasma accelerators, which underlie their viability for applications demanding high average beam current.

Published
2020
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32. Ontogeny of Carbon Monoxide-Related Gene Expression in a Deep-Diving Marine Mammal.

Author

Piotrowski, Elizabeth R, Tift, Michael S, Crocker, Daniel E, Pearson, Anna B, Vázquez-Medina, José P, Keith, Anna D, and Khudyakov, Jane I

Subjects
carbon monoxide, diving physiology, gene expression, heme oxygenase, hypoxia tolerance, marine mammal, Genetics, 1.1 Normal biological development and functioning, Underpinning research, Physiology, Medical Physiology, Psychology
Abstract

Marine mammals such as northern elephant seals (NES) routinely experience hypoxemia and ischemia-reperfusion events to many tissues during deep dives with no apparent adverse effects. Adaptations to diving include increased antioxidants and elevated oxygen storage capacity associated with high hemoprotein content in blood and muscle. The natural turnover of heme by heme oxygenase enzymes (encoded by HMOX1 and HMOX2) produces endogenous carbon monoxide (CO), which is present at high levels in NES blood and has been shown to have cytoprotective effects in laboratory systems exposed to hypoxia. To understand how pathways associated with endogenous CO production and signaling change across ontogeny in diving mammals, we measured muscle CO and baseline expression of 17 CO-related genes in skeletal muscle and whole blood of three age classes of NES. Muscle CO levels approached those of animals exposed to high exogenous CO, increased with age, and were significantly correlated with gene expression levels. Muscle expression of genes associated with CO production and antioxidant defenses (HMOX1, BVR, GPX3, PRDX1) increased with age and was highest in adult females, while that of genes associated with protection from lipid peroxidation (GPX4, PRDX6, PRDX1, SIRT1) was highest in adult males. In contrast, muscle expression of mitochondrial biogenesis regulators (PGC1A, ESRRA, ESRRG) was highest in pups, while genes associated with inflammation (HMOX2, NRF2, IL1B) did not vary with age or sex. Blood expression of genes involved in regulation of inflammation (IL1B, NRF2, BVR, IL10) was highest in pups, while HMOX1, HMOX2 and pro-inflammatory markers (TLR4, CCL4, PRDX1, TNFA) did not vary with age. We propose that ontogenetic upregulation of baseline HMOX1 expression in skeletal muscle of NES may, in part, underlie increases in CO levels and expression of genes encoding antioxidant enzymes. HMOX2, in turn, may play a role in regulating inflammation related to ischemia and reperfusion in muscle and circulating immune cells. Our data suggest putative ontogenetic mechanisms that may enable phocid pups to transition to a deep-diving lifestyle, including high baseline expression of genes associated with mitochondrial biogenesis and immune system activation during postnatal development and increased expression of genes associated with protection from lipid peroxidation in adulthood.

Published
2021

37. Measurement of the $K^+\rightarrow{\mu^+}{\nu_{\mu}}{\gamma}$ decay form factors in the OKA experiment

Author

Kravtsov, V. I., Duk, V. A., Filippov, S. N., Gushchin, E. N., Khudyakov, A. A., Kudenko, Yu. G., Polyarush, A. Yu., Akimenko, S. A., Artamonov, A. V., Blik, A. M., Burtovoy, V. S., Donskov, S. V., Filin, A. P., Gorin, A. M., Inyakin, A. V., Khaustov, G. V., Kholodenko, S. A., Kolosov, V. N., Kurshetsov, V. F., Lishin, V. A., Medynsky, M. V., Mikhailov, Yu. V., Obraztsov, V. F., Polyakov, V. A., Popov, A. V., Romanovsky, V. I., Rykalin, V. I., Sadovsky, A. S., Samoilenko, V. D., Semenov, V. K., Shapkin, M. M., Stenyakin, O. V., Tchikilev, O. G., Uvarov, V. A., Yushchenko, O. P., Bychkov, V. N., Kekelidze, G. D., Lysan, V. M., and Zalikhanov, B. Zh.

Subjects
High Energy Physics - Experiment, Nuclear Experiment
Abstract

A precise measurement of the vector and axial-vector form factors difference $F_V-F_A$ in the $K^+\rightarrow{\mu^+}{\nu_{\mu}}{\gamma}$ decay is presented. About 95K events of $K^+\rightarrow{\mu^+}{\nu_{\mu}}{\gamma}$ are selected in the OKA experiment. The result is $F_V-F_A=0.134\pm0.021(stat)\pm0.027(syst)$. Both errors are smaller than in the previous $F_V-F_A$ measurements., Comment: 9 pages, 8 figures

Published
2019
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39. Contributors

Author

Abzug, Mark J., primary, Acharya, Priyamvada, additional, Acosta, Anna M., additional, Ahmed, S. Sohail, additional, Amanna, Ian J., additional, Anderson, Annaliesa S., additional, Asturias, Edwin J., additional, Bachmann, Martin F., additional, Bahl, Sunil, additional, Bailey, Justin R., additional, Baker, Carol J., additional, Balfour, Henry H., additional, Baric, Ralph S., additional, Barnett, Elizabeth D., additional, Barrett, Alan D.T., additional, Belser, Jessica A., additional, Berzofsky, Jay A., additional, Bethony, Jeffrey M., additional, Brewer-Jensen, Paul D., additional, Bubak, Andrew N., additional, Burns, Cara C., additional, Caplan, Arthur L., additional, Cavaleri, Marco, additional, Chandran, Aruna, additional, Cherian, Thomas, additional, Clemens, John D., additional, Cochino, Emil, additional, Cohet, Catherine, additional, Cohn, Amanda, additional, Cortese, Margaret M., additional, Crowcroft, Natasha S., additional, Curtis, Nigel, additional, Damron, F. Heath, additional, Danchin, Margie, additional, Debbink, Kari, additional, Desai, Sachin N., additional, Davis, Emily H., additional, Decker, Michael D., additional, Denison, Mark R., additional, DeStefano, Frank, additional, Douglas, R. Gordon, additional, Dreher-Lesnick, Sheila M., additional, Eberhardt, Christiane S., additional, Edmunds, W. John, additional, Edwards, Caitlin E., additional, Edwards, Kathryn M., additional, Eggers, Rudolf, additional, Ellis, Ronald, additional, Erdman, Dean D., additional, Ertl, Hildegund C.J., additional, Estivariz, Concepcion F., additional, Fine, Paul E.M., additional, Finn, Theresa M., additional, Fisher, Allison M., additional, Fitzwater, Sean Patrick, additional, Freedman, Mark S., additional, Friede, Martin, additional, Friedlander, Arthur M., additional, Frumento, Nicole, additional, Fry, Alicia M., additional, Garçon, Nathalie, additional, Geris, Jennifer M., additional, Gershon, Anne A., additional, Gervier, Regis, additional, Gessner, Bradford D., additional, Gilbert, Peter B., additional, Gomez, Phillip Louis, additional, Ginsberg, Ann M., additional, Grabenstein, John D., additional, Graham, Rachel L., additional, Graham, Barney S., additional, Granoff, Dan M., additional, Gray, Gregory C., additional, Greenberg, David P., additional, Grohskopf, Lisa A., additional, Gruber, Marion F., additional, Guerena, Fernando B., additional, Havelange, Nicolas, additional, Halstead, Scott B., additional, Hanekom, Willem A., additional, Harrison, Lee H., additional, Hawn, Thomas R., additional, Haynes, Barton F., additional, Healy, C. Mary, additional, Hills, Susan L., additional, Hirabayashi, Kuniko, additional, Holmgren, Jan, additional, Hombach, Joachim M., additional, Hotez, Peter Jay, additional, Howe, Barbara J., additional, Hunegnaw, Ruth, additional, Izopet, Jacques, additional, Jamieson, Denise J., additional, Jansen, Kathrin, additional, Jarrahian, Courtney, additional, Johansen, Kari, additional, Kahn, Geoffrey D., additional, Karron, Ruth A., additional, Katz, Jacqueline M., additional, Kennedy, Richard B., additional, Broojerdi, Alireza Khadem, additional, Khetsuriani, Nino, additional, Khudyakov, Yury, additional, Klugman, Keith P., additional, Kocher, Jacob F., additional, Kollaritsch, Herwig, additional, Kotloff, Karen L., additional, Kozarsky, Phyllis E., additional, Kreimer, Aimée R., additional, Kroger, Andrew T., additional, Kwong, Peter D., additional, Lal, Manjari, additional, Levin, Myron J., additional, Levine, Myron M., additional, Lindesmith, Lisa C., additional, Lindstrand, Ann, additional, Ljungman, Per, additional, Lowy, Douglas R., additional, Lundgren, Anna, additional, Lydon, Patrick, additional, Macklin, Grace R., additional, Maeng, Hoyoung M., additional, Mahalingam, Ravi, additional, Malley, Richard, additional, Mallory, Michael L., additional, Marfin, Anthony A., additional, Markowitz, Lauri E., additional, Marshall, CDR Valerie, additional, McCollum, Andrea, additional, Meyer, Sarah, additional, McNamara, Lucy A., additional, Menning, Lisa, additional, Messacar, Kevin, additional, Miller, Mark A., additional, Milutinovic, Pavle, additional, Modlin, John F., additional, Monath, Thomas P., additional, Morabito, Kaitlyn M., additional, Moss, William J., additional, Mulholland, Kim, additional, Mura, Manuela, additional, Musher, Daniel M., additional, Nagel, Maria A., additional, Nair, G. Balakrish, additional, Nelson, Noele P., additional, Netea, Mihai G., additional, Neuzil, Kathleen Maletic, additional, Niemeyer, Christy S., additional, Nohynek, Hanna, additional, Norheim, Gunnstein, additional, Nussbaum, Lauren, additional, O’Brien, Katherine L., additional, O’Leary, Sean, additional, Ockenhouse, Christian, additional, Offit, Paul A., additional, Okwo-Bele, Jean-Marie, additional, Olkhanud, Purevdorj B., additional, Omer, Saad B., additional, Orenstein, Walter A., additional, Oyston, Petra C.F., additional, Parashar, Umesh D., additional, Patel, Manish M., additional, Payne, Daniel C., additional, Pebody, Richard, additional, Pecetta, Simone, additional, Perlman, Stanley, additional, Pierson, Benjamin, additional, Pierson, Theodore C., additional, Pittet, Laure F., additional, Pittman, Phillip R., additional, Plotkin, Stanley A., additional, Plotkin, Susan L., additional, Poland, Gregory A., additional, Pollard, Sir Andrew John, additional, Poovorawan, Yong, additional, Proctor, Richard A., additional, Qadri, Firdausi, additional, Rao, Agam, additional, Rappuoli, Rino, additional, Reef, Susan E., additional, Rogalewicz, Joseph A., additional, Robinson, James Michael, additional, Roesel, Sigrun, additional, Rubin, Steven A., additional, Rupprecht, Charles E., additional, Rutter, Paul, additional, Samant, Vijay B., additional, Sambhara, Suryaprakash, additional, Samies, Nicole L., additional, Santosham, Mathuram, additional, Saunders, Kevin O., additional, Schiller, John T., additional, Schleiss, Mark R., additional, Schuerman, Lode, additional, Schwab, Jennifer, additional, Schwartz, Jason L., additional, Scobie, Heather M., additional, Scott, J. Anthony, additional, Shapiro, Eugene D., additional, Shenoy, Erica S., additional, Shimabukuro, Tom T., additional, Shouval, Daniel, additional, Siegrist, Claire-Anne, additional, Sitrin, Robert D., additional, Skinner, Nicole E., additional, Slifka, Mark K., additional, Sodha, Samir V., additional, Soeters, Heidi M., additional, Solomon, Tom, additional, Speiser, Daniel E., additional, Staples, J. Erin, additional, Steffen, Robert, additional, Stephens, David S., additional, Strebel, Peter M., additional, Subbarao, Kanta, additional, Sullivan, Nancy J., additional, Takashima, Yoshihiro, additional, Tate, Jacqueline E., additional, Tayman, Alice, additional, Telford, Sam R., additional, Thombley, Melisa, additional, Thomsen, Isaac, additional, Tohme, Rania A., additional, Trabold, Malin, additional, El-Turabi, Aadil, additional, Vaughn, David W., additional, Verardi, Raffaello, additional, Vicari, Andrea S., additional, Vidor, Emmanuel J., additional, Villafana, Tonya, additional, Vogt, Matthew R., additional, Walker, Mark J., additional, Walsh, Nick M., additional, Wanlapakorn, Nasamon, additional, Ward, John W., additional, Wassilak, Steven G.F., additional, Watts, Lisa A., additional, Weber, David J., additional, Weiner, David B., additional, Weng, Mark K., additional, Wexler, Deborah L., additional, Wharton, Melinda, additional, Whitley, Richard J., additional, Whitney, Cynthia G., additional, Wiehe, Kevin, additional, Williamson, E. Diane, additional, Wormser, Gary P., additional, Xia, Ningshao, additional, Yildirim, Inci, additional, Zehrung, Darin, additional, and Zweigart, Mark R., additional

Published
2023
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40. Optimization of Wastes Compaction Parameters in Case of Gradual Wear of the Briquetting Press Rolls

Author

Baiul, Kostiantyn, Vashchenko, Sergii, Khudyakov, Aleksander, Krot, Pavlo, Solodka, Nataliia, Correia, José A. F. O., Series Editor, De Jesus, Abílio M. P., Series Editor, Ayatollahi, Majid Reza, Advisory Editor, Berto, Filippo, Advisory Editor, Fernández-Canteli, Alfonso, Advisory Editor, Hebdon, Matthew, Advisory Editor, Kotousov, Andrei, Advisory Editor, Lesiuk, Grzegorz, Advisory Editor, Murakami, Yukitaka, Advisory Editor, Carvalho, Hermes, Advisory Editor, Zhu, Shun-Peng, Advisory Editor, Bordas, Stéphane, Advisory Editor, Fantuzzi, Nicholas, Advisory Editor, Susmel, Luca, Advisory Editor, Dutta, Subhrajit, Advisory Editor, Maruschak, Pavlo, Advisory Editor, Fedorova, Elena, Advisory Editor, Szata, Mieczyslaw, editor, Blazejewski, Wojciech, editor, Jesus, Abílio M.P. de, editor, and Correia, José A.F.O., editor

Published
2022
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41. Discretion and Continuity of Psychological Space

Author

Khudyakov, Andrey, Spagnoletti, Paolo, Series Editor, De Marco, Marco, Series Editor, Pouloudi, Nancy, Series Editor, Te'eni, Dov, Series Editor, vom Brocke, Jan, Series Editor, Winter, Robert, Series Editor, Baskerville, Richard, Series Editor, Zaramenskikh, Evgeny, editor, and Fedorova, Alena, editor

Published
2022
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43. Study of the decay $K^{+}\to\pi^{+}\pi^{-}\pi^{+}\gamma$ in the OKA experiment

Author

Shapkin, M. M., Akimenko, S. A., Artamonov, A. V., Blik, A. M., Burtovoy, V. S., Donskov, S. V., Filin, A. P., Inyakin, A. V., Gorin, A. M., Khaustov, G. V., Kholodenko, S. A., Kolosov, V. N., Konstantinov, A. S., Kurshetsov, V. F., Lishin, V. A., Medynsky, M. V., Mikhailov, Yu. V., Obraztsov, V. F., Polyakov, V. A., Popov, A. V., Romanovsky, V. I., Rykalin, V. I., Sadovsky, A. S., Samoilenko, V. D., Semenov, V. K., Stenyakin, O. V., Tchikilev, O. G., Uvarov, V. A., Yushchenko, O. P., Duk, V. A., Filippov, S. N., Guschin, E. N., Khudyakov, A. A., Kravtsov, V. I., Kudenko, Yu. G., Polyarush, A. Yu., Bychkov, V. N., Kekelidze, G. D., Lysan, V. M., and Zalikhanov, B. Zh.

Subjects
High Energy Physics - Experiment
Abstract

A high statistics data sample of the decays of $K^+$ mesons to three charged particles was accumulated by the OKA experiment in 2012 and 2013. This allowed to select a clean sample of about 450 events with $K^{+}\to\pi^{+}\pi^{-}\pi^{+}\gamma$ decays with the energy of the photon in the kaon rest frame greater than 30 MeV. The measured branching fraction of the $K^{+}\to\pi^{+}\pi^{-}\pi^{+}\gamma$, with $E_{\gamma}^{*}$ > 30 MeV is $(0.71 \pm 0.05) \times 10^{-5}$. The measured energy spectrum of the decay photon is compared with the prediction of the chiral perturbation theory to O$(p^{4})$. A search for an up-down asymmetry of the photon with respect to the hadronic system decay plane is also performed., Comment: 9 pages, 7 figures, 1 table

Published
2018
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44. Search for $K^{+}\rightarrow\pi^{+}\nu\overline{\nu}$ at NA62

Author

NA62 Collaboration, Rinella, G. Aglieri, Aliberti, R., Ambrosino, F., Ammendola, R., Angelucci, B., Antonelli, A., Anzivino, G., Arcidiacono, R., Azhinenko, I., Balev, S., Barbanera, M., Bendotti, J., Biagioni, A., Bician, L., Biino, C., Bizzeti, A., Blazek, T., Blik, A., Bloch-Devaux, B., Bolotov, V., Bonaiuto, V., Boretto, M., Bragadireanu, M., Britton, D., Britvich, G., Brunetti, M. B., Bryman, D., Bucci, F., Butin, F., Calvo, J., Capitolo, E., Capoccia, C., Capussela, T., Cassese, A., Catinaccio, A., Cecchetti, A., Ceccucci, A., Cenci, P., Cerny, V., Cerri, C., Checcucci, B., Chikilev, O., Chiozzi, S., Ciaranfi, R., Collazuol, G., Conovaloff, A., Cooke, P., Cooper, P., Corradi, G., Gil, E. Cortina, Costantini, F., Cotorobai, F., Ramusino, A. Cotta, Coward, D., D'Agostini, G., Dainton, J., Dalpiaz, P., Danielsson, H., Degrange, J., De Simone, N., Di Filippo, D., Di Lella, L., Di Lorenzo, S., Dixon, N., Doble, N., Dobrich, B., Duk, V., Elsha, V., Engelfried, J., Enik, T., Estrada, N., Falaleev, V., Fantechi, R., Fascianelli, V., Federici, L., Fedotov, S., Filippi, A., Fiorini, M., Fry, J., Fu, J., Fucci, A., Fulton, L., Gallorini, S., Galeotti, S., Gamberini, E., Gatignon, L., Georgiev, G., Ghinescu, S., Gianoli, A., Giorgi, M., Giudici, S., Glonti, L., Martins, A. Goncalves, Gonnella, F., Goudzovski, E., Guida, R., Gushchin, E., Hahn, F., Hallgren, B., Heath, H., Herman, F., Husek, T., Hutanu, O., Hutchcroft, D., Iacobuzio, L., Iacopini, E., Imbergamo, E., Jamet, O., Jarron, P., Jones, E., Kampf, T. Jones K., Kaplon, J., Kekelidze, V., Kholodenko, S., Khoriauli, G., Khotyantsev, A., Khudyakov, A., Kiryushin, Yu., Kleimenova, A., Kleinknecht, K., Kluge, A., Koval, M., Kozhuharov, V., Krivda, M., Kucerova, Z., Kudenko, Yu., Kunze, J., Lamanna, G., Latino, G., Lazzeroni, C., Lehmann-Miotto, G., Lenci, R., Lenti, M., Leonardi, E., Lichard, P., Lietava, R., Likhacheva, V., Litov, L., Lollini, R., Lomidze, D., Lonardo, A., Lupi, M., Lurkin, N., McCormick, K., Madigozhin, D., Maire, G., Mandeiro, C., Mannelli, I., Mannocchi, G., Mapelli, A., Marchetto, F., Marchevski, R., Martellotti, S., Massarotti, P., Massri, K., Matak, P., Maurice, E., Medvedeva, M., Mefodev, A., Menichetti, E., Migliore, E., Minucci, E., Mirra, M., Misheva, M., Molokanova, N., Morant, J., Morel, M., Moulson, M., Movchan, S., Munday, D., Napolitano, M., Neri, I., Newson, F., Noël, J., Norton, A., Noy, M., Nuessle, G., Numao, T., Obraztsov, V., Ostankov, A., Padolski, S., Page, R., Palladino, V., Paoluzzi, G., Parkinson, C., Pedreschi, E., Pepe, M., Gomez, F. Perez, Perrin-Terrin, M., Peruzzo, L., Petrov, P., Petrucci, F., Piandani, R., Piccini, M., Pietreanu, D., Pinzino, J., Polenkevich, I., Pontisso, L., Potrebenikov, Yu., Protopopescu, D., Raffaelli, F., Raggi, M., Riedler, P., Romano, A., Rubin, P., Ruggiero, G., Russo, V., Ryjov, V., Salamon, A., Salina, G., Samsonov, V., Santoni, C., Saracino, G., Sargeni, F., Semenov, V., Sergi, A., Serra, M., Shaikhiev, A., Shkarovskiy, S., Skillicorn, I., Soldi, D., Sotnikov, A., Sugonyaev, V., Sozzi, M., Spadaro, T., Spinella, F., Staley, R., Sturgess, A., Sutcliffe, P., Szilasi, N., Tagnani, D., Trilov, S., Valdata-Nappi, M., Valente, P., Vasile, M., Vassilieva, T., Velghe, B., Veltri, M., Venditti, S., Vicini, P., Volpe, R., Vormstein, M., Wahl, H., Wanke, R., Wertelaers, P., Winhart, A., Winston, R., Wrona, B., Yushchenko, O., Zamkovsky, M., and Zinchenko, A.

Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

$K^{+}\rightarrow\pi^{+}\nu\overline{\nu}$ is one of the theoretically cleanest meson decay where to look for indirect effects of new physics complementary to LHC searches. The NA62 experiment at CERN SPS is designed to measure the branching ratio of this decay with 10\% precision. NA62 took data in pilot runs in 2014 and 2015 reaching the final designed beam intensity. The quality of 2015 data acquired, in view of the final measurement, will be presented., Comment: proceeding of the conference New Trends in High-Energy Physics 2016

Published
2018

45. The design optimization and experimental investigation of the 4420 nm Raman laser based on hydrogen-filled revolver silica fiber

Author

Kolyadin, A. N., Astapovich, M. S., Gladyshev, A. V., Kosolapov, A. F., Pryamikov, A. D., Alagashev, K. G., Khudyakov, M. M., Likhachev, M. E., and Bufetov, I. A.

Subjects
Physics - Optics
Abstract

Optical properties of hollow-core revolver fibers are numerically investigated depending on various parameters: the hollow-core diameter, the capillary wall thickness, the values of the minimum gap between the capillaries, the number of capillaries in the cladding and the type of glass (silica and chalcogenide). Preliminary, similar calculations are made for simple models of hollow-core fibers. Based on the obtained results, the optimal design of the revolver fiber for Raman laser frequency conversion (1560 nm to 4420 nm in H2) was determined. As a result, efficient ns-pulsed 4420 nm Raman laser based on H2-filled revolver silica fiber is realized. Quantum efficiency as high as 36 % is achieved and output average power as high as 250 mW is demonstrated., Comment: 13 pages, 11 figures

Published
2018

46. Efficient 4.42 {\mu}m Raman laser based on hollow-core silica fiber

Author

Astapovich, Maxim S., Kolyadin, Anton N., Gladyshev, Alexey V., Kosolapov, Alexey F., Pryamikov, Andrey D., Khudyakov, Maxim M., Likhachev, Mikhail E., and Bufetov, Igor A.

Subjects
Physics - Optics
Abstract

In this paper we consider mid-infrared Raman lasers based on gas-filled hollow-core silica fibers and provide theoretical and experimental analysis of factors that limit the efficiency and output power of these lasers. As a result, we realized an efficient ns-pulsed 4.42 {\mu}m Raman laser based on an 1H2-filled revolver silica fiber. Quantum efficiency as high as 36 % is achieved, and output average power as high as 250 mW is demonstrated. The possibilities of further improving the laser efficiency are discussed.

Published
2018

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