Search

We report on a search for millicharged particles (mCPs) produced in cosmic ray proton atmospheric interactions using data collected during the first science run of the LUX-ZEPLIN experiment. The mCPs produced by two processes -- meson decay and proton bremsstrahlung -- are considered in this study. This search utilized a novel signature unique to liquid xenon (LXe) time projection chambers (TPCs), allowing sensitivity to mCPs with masses ranging from 10 to 1000 MeV/c$^2$ and fractional charges between 0.001 and 0.02 of the electron charge e. With an exposure of 60 live days and a 5.5 tonne fiducial mass, we observed no significant excess over background. This represents the first experimental search for atmospheric mCPs and the first search for mCPs using an underground LXe experiment.

Large language models (LLMs) are increasingly deployed via public-facing interfaces to interact with millions of users, each with diverse preferences. Despite this, preference tuning of LLMs predominantly relies on reward models trained using binary judgments where annotators select the preferred choice out of pairs of model outputs. In this work, we argue that this reliance on binary choices does not capture the broader, aggregate preferences of the target user in real-world tasks. We propose a taxonomy that identifies two dimensions of subjectivity where different users disagree on the preferred output-namely, the Plurality of Responses to Prompts, where prompts allow for multiple correct answers, and the Indistinguishability of Responses, where candidate outputs are paraphrases of each other. We show that reward models correlate weakly with user preferences in these cases. As a first step to address this issue, we introduce a simple yet effective method that augments existing binary preference datasets with synthetic preference judgments to estimate potential user disagreement. Incorporating these via a margin term as a form of regularization during model training yields predictions that better align with the aggregate user preferences.

Cluster analyses of high-dimensional data are often hampered by the presence of large numbers of variables that do not provide relevant information, as well as the perennial issue of choosing an appropriate number of clusters. These challenges are frequently encountered when analysing `omics datasets, such as in molecular precision medicine, where a key goal is to identify disease subtypes and the biomarkers that define them. Here we introduce an annealed variational Bayes algorithm for fitting high-dimensional mixture models while performing variable selection. Our algorithm is scalable and computationally efficient, and we provide an open source Python implementation, VBVarSel. In a range of simulated and real biomedical examples, we show that VBVarSel outperforms the current state of the art, and demonstrate its use for cancer subtyping and biomarker discovery.

With the advancement of large language models (LLMs), the biomedical domain has seen significant progress and improvement in multiple tasks such as biomedical question answering, lay language summarization of the biomedical literature, clinical note summarization, etc. However, hallucinations or confabulations remain one of the key challenges when using LLMs in the biomedical and other domains. Inaccuracies may be particularly harmful in high-risk situations, such as making clinical decisions or appraising biomedical research. Studies on the evaluation of the LLMs' abilities to ground generated statements in verifiable sources have shown that models perform significantly worse on lay-user generated questions, and often fail to reference relevant sources. This can be problematic when those seeking information want evidence from studies to back up the claims from LLMs[3]. Unsupported statements are a major barrier to using LLMs in any applications that may affect health. Methods for grounding generated statements in reliable sources along with practical evaluation approaches are needed to overcome this barrier. Towards this, in our pilot task organized at TREC 2024, we introduced the task of reference attribution as a means to mitigate the generation of false statements by LLMs answering biomedical questions.

Legacy software systems, written in outdated languages like MUMPS and mainframe assembly, pose challenges in efficiency, maintenance, staffing, and security. While LLMs offer promise for modernizing these systems, their ability to understand legacy languages is largely unknown. This paper investigates the utilization of LLMs to generate documentation for legacy code using two datasets: an electronic health records (EHR) system in MUMPS and open-source applications in IBM mainframe Assembly Language Code (ALC). We propose a prompting strategy for generating line-wise code comments and a rubric to evaluate their completeness, readability, usefulness, and hallucination. Our study assesses the correlation between human evaluations and automated metrics, such as code complexity and reference-based metrics. We find that LLM-generated comments for MUMPS and ALC are generally hallucination-free, complete, readable, and useful compared to ground-truth comments, though ALC poses challenges. However, no automated metrics strongly correlate with comment quality to predict or measure LLM performance. Our findings highlight the limitations of current automated measures and the need for better evaluation metrics for LLM-generated documentation in legacy systems., Comment: Abbreviated version submitted to LLM4Code 2025 (a workshop co-located with ICSE 2025), 13 pages, 3 figures

The capabilities and limitations of Large Language Models have been sketched out in great detail in recent years, providing an intriguing yet conflicting picture. On the one hand, LLMs demonstrate a general ability to solve problems. On the other hand, they show surprising reasoning gaps when compared to humans, casting doubt on the robustness of their generalisation strategies. The sheer volume of data used in the design of LLMs has precluded us from applying the method traditionally used to measure generalisation: train-test set separation. To overcome this, we study what kind of generalisation strategies LLMs employ when performing reasoning tasks by investigating the pretraining data they rely on. For two models of different sizes (7B and 35B) and 2.5B of their pretraining tokens, we identify what documents influence the model outputs for three simple mathematical reasoning tasks and contrast this to the data that are influential for answering factual questions. We find that, while the models rely on mostly distinct sets of data for each factual question, a document often has a similar influence across different reasoning questions within the same task, indicating the presence of procedural knowledge. We further find that the answers to factual questions often show up in the most influential data. However, for reasoning questions the answers usually do not show up as highly influential, nor do the answers to the intermediate reasoning steps. When we characterise the top ranked documents for the reasoning questions qualitatively, we confirm that the influential documents often contain procedural knowledge, like demonstrating how to obtain a solution using formulae or code. Our findings indicate that the approach to reasoning the models use is unlike retrieval, and more like a generalisable strategy that synthesises procedural knowledge from documents doing a similar form of reasoning.

Objectives: Despite the recent adoption of large language models (LLMs) for biomedical information extraction, challenges in prompt engineering and algorithms persist, with no dedicated software available. To address this, we developed LLM-IE: a Python package for building complete information extraction pipelines. Our key innovation is an interactive LLM agent to support schema definition and prompt design. Materials and Methods: The LLM-IE supports named entity recognition, entity attribute extraction, and relation extraction tasks. We benchmarked on the i2b2 datasets and conducted a system evaluation. Results: The sentence-based prompting algorithm resulted in the best performance while requiring a longer inference time. System evaluation provided intuitive visualization. Discussion: LLM-IE was designed from practical NLP experience in healthcare and has been adopted in internal projects. It should hold great value to the biomedical NLP community. Conclusion: We developed a Python package, LLM-IE, that provides building blocks for robust information extraction pipeline construction.

An extreme yet reconfigurable nonlinear response to a single photon by a photonic system is crucial for realizing a universal two-photon gate, an elementary building block for photonic quantum computing. Yet such a response, characterized by the photon blockade effect, has only been achieved in atomic systems or solid states ones that are difficult to scale up. Here we demonstrate electrically tunable partial photon blockade in dipolar waveguide polaritons on a semiconductor chip, measured via photon-correlations. Remarkably, these "dipolar photons" display a two-orders-of-magnitude stronger nonlinearity compared to unpolarized polaritons, with an extracted dipolar blockade radius up to more than 4 $\mu$m, significantly larger than the optical wavelength, and comparable to that of atomic Rydberg polaritons. Furthermore, we show that the dipolar interaction can be electrically switched and locally configured by simply tuning the gate voltage. Finally we show that with a simple modification of the design, a full photon blockade is expected, setting a new route towards scalable, reconfigurable, chip-integrated quantum photonic circuits with strong two-photon nonlinearities., Comment: 30 pages, 11 figures

In this Letter we report on the experimental generation of high energy (10 GeV), ultra-short (fs-duration), ultra-high current (0.1 MA), petawatt peak power electron beams in a particle accelerator. These extreme beams enable the exploration of a new frontier of high intensity beam-light and beam-matter interactions broadly relevant across fields ranging from laboratory astrophysics to strong field quantum electrodynamics and ultra-fast quantum chemistry. We demonstrate our ability to generate and control the properties of these electron beams by means of a laser-electron beam shaping technique. This experimental demonstration opens the door to on-the-fly customization of extreme beam current profiles for desired experiments and is poised to benefit a broad swathe of cross-cutting applications of relativistic electron beams.

In the span of four decades, quantum computation has evolved from an intellectual curiosity to a potentially realizable technology. Today, small-scale demonstrations have become possible for quantum algorithmic primitives on hundreds of physical qubits and proof-of-principle error-correction on a single logical qubit. Nevertheless, despite significant progress and excitement, the path toward a full-stack scalable technology is largely unknown. There are significant outstanding quantum hardware, fabrication, software architecture, and algorithmic challenges that are either unresolved or overlooked. These issues could seriously undermine the arrival of utility-scale quantum computers for the foreseeable future. Here, we provide a comprehensive review of these scaling challenges. We show how the road to scaling could be paved by adopting existing semiconductor technology to build much higher-quality qubits, employing system engineering approaches, and performing distributed quantum computation within heterogeneous high-performance computing infrastructures. These opportunities for research and development could unlock certain promising applications, in particular, efficient quantum simulation/learning of quantum data generated by natural or engineered quantum systems. To estimate the true cost of such promises, we provide a detailed resource and sensitivity analysis for classically hard quantum chemistry calculations on surface-code error-corrected quantum computers given current, target, and desired hardware specifications based on superconducting qubits, accounting for a realistic distribution of errors. Furthermore, we argue that, to tackle industry-scale classical optimization and machine learning problems in a cost-effective manner, distributed quantum-assisted probabilistic computing with custom-designed accelerators should be considered as a complementary path toward scalability., Comment: 50 pages, 42 figures

Backgrounds: Information extraction (IE) is critical in clinical natural language processing (NLP). While large language models (LLMs) excel on generative tasks, their performance on extractive tasks remains debated. Methods: We investigated Named Entity Recognition (NER) and Relation Extraction (RE) using 1,588 clinical notes from four sources (UT Physicians, MTSamples, MIMIC-III, and i2b2). We developed an annotated corpus covering 4 clinical entities and 16 modifiers, and compared instruction-tuned LLaMA-2 and LLaMA-3 against BiomedBERT in terms of performance, generalizability, computational resources, and throughput to BiomedBERT. Results: LLaMA models outperformed BiomedBERT across datasets. With sufficient training data, LLaMA showed modest improvements (1% on NER, 1.5-3.7% on RE); improvements were larger with limited training data. On unseen i2b2 data, LLaMA-3-70B outperformed BiomedBERT by 7% (F1) on NER and 4% on RE. However, LLaMA models required more computing resources and ran up to 28 times slower. We implemented "Kiwi," a clinical IE package featuring both models, available at https://kiwi.clinicalnlp.org/. Conclusion: This study is among the first to develop and evaluate a comprehensive clinical IE system using open-source LLMs. Results indicate that LLaMA models outperform BiomedBERT for clinical NER and RE but with higher computational costs and lower throughputs. These findings highlight that choosing between LLMs and traditional deep learning methods for clinical IE applications should remain task-specific, taking into account both performance metrics and practical considerations such as available computing resources and the intended use case scenarios.

Recent advancements in artificial intelligence (AI) for numerical weather prediction (NWP) have significantly transformed atmospheric modeling. AI NWP models outperform traditional physics-based systems, such as the Integrated Forecast System (IFS), across several global metrics while requiring fewer computational resources. However, existing AI NWP models face limitations related to training datasets and timestep choices, often resulting in artifacts that reduce model performance. To address these challenges, we introduce the Community Research Earth Digital Intelligence Twin (CREDIT) framework, developed at NSF NCAR. CREDIT provides a flexible, scalable, and user-friendly platform for training and deploying AI-based atmospheric models on high-performance computing systems. It offers an end-to-end pipeline for data preprocessing, model training, and evaluation, democratizing access to advanced AI NWP capabilities. We demonstrate CREDIT's potential through WXFormer, a novel deterministic vision transformer designed to predict atmospheric states autoregressively, addressing common AI NWP issues like compounding error growth with techniques such as spectral normalization, padding, and multi-step training. Additionally, to illustrate CREDIT's flexibility and state-of-the-art model comparisons, we train the FUXI architecture within this framework. Our findings show that both FUXI and WXFormer, trained on six-hourly ERA5 hybrid sigma-pressure levels, generally outperform IFS HRES in 10-day forecasts, offering potential improvements in efficiency and forecast accuracy. CREDIT's modular design enables researchers to explore various models, datasets, and training configurations, fostering innovation within the scientific community.

Many workers in cities across the world, who have been teleworking because of the COVID-19 pandemic, are expected to be back to their commutes. As this process is believed to be gradual and telecommuting is likely to remain an option for many workers, hybrid model and flexible schedules might become the norm in the future. This variable work schedules allows employees to commute outside of traditional rush hours. Moreover, many studies showed that commuters might be skeptical of using trains, buses, and carpools and could turn to personal vehicles to get to work, which might increase congestion and crashes in the roads. This study attempts to provide information on the safest time to commute to Washington, DC area analyzing historical traffic crash data before the COVID-19 pandemic. It also aims to advance our understanding of traffic crashes and other relating factors such as weather in the Washington, DC area. We created a model to predict crashes by time of the day, using a negative binomial regression after rejecting a Poisson regression, and additionally explored the validity of a Random Forest regression. Our main consideration for an eventual application of this study is to reduce crashes in Washington DC, using this tool that provides people with better options on when to commute and when to telework, if available. The study also provides policymakers and researchers with real-world insights that decrease the number of traffic crashes to help achieve the goals of The Vision Zero Initiative adopted by the district.

Generating discharge summaries is a crucial yet time-consuming task in clinical practice, essential for conveying pertinent patient information and facilitating continuity of care. Recent advancements in large language models (LLMs) have significantly enhanced their capability in understanding and summarizing complex medical texts. This research aims to explore how LLMs can alleviate the burden of manual summarization, streamline workflow efficiencies, and support informed decision-making in healthcare settings. Clinical notes from a cohort of 1,099 lung cancer patients were utilized, with a subset of 50 patients for testing purposes, and 102 patients used for model fine-tuning. This study evaluates the performance of multiple LLMs, including GPT-3.5, GPT-4, GPT-4o, and LLaMA 3 8b, in generating discharge summaries. Evaluation metrics included token-level analysis (BLEU, ROUGE-1, ROUGE-2, ROUGE-L) and semantic similarity scores between model-generated summaries and physician-written gold standards. LLaMA 3 8b was further tested on clinical notes of varying lengths to examine the stability of its performance. The study found notable variations in summarization capabilities among LLMs. GPT-4o and fine-tuned LLaMA 3 demonstrated superior token-level evaluation metrics, while LLaMA 3 consistently produced concise summaries across different input lengths. Semantic similarity scores indicated GPT-4o and LLaMA 3 as leading models in capturing clinical relevance. This study contributes insights into the efficacy of LLMs for generating discharge summaries, highlighting LLaMA 3's robust performance in maintaining clarity and relevance across varying clinical contexts. These findings underscore the potential of automated summarization tools to enhance documentation precision and efficiency, ultimately improving patient care and operational capability in healthcare settings.

We present the first broadband near- to mid-infrared (3-12 microns) transmission spectrum of the highly-irradiated (T_eq = 981 K) M dwarf rocky planet L 168-9 b (TOI-134 b) observed with the NIRSpec and MIRI instruments aboard JWST. We measure the near-infrared transit depths to a combined median precision of 20 ppm across the three visits in 54 spectroscopic channels with uniform widths of 60 pixels (~0.2 microns wide; R~100), and the mid-infrared transit depths to 61 ppm median precision in 48 wavelength bins (~0.15 microns wide; R~50). We compare the transmission spectrum of L 168-9 b to a grid of 1D thermochemical equilibrium forward models, and rule out atmospheric metallicities of less than 100x solar (mean molecular weights <4 g mol$^{-1}$) to 3-sigma confidence assuming high surface pressure (>1 bar), cloudless atmospheres. Based on photoevaporation models for L 168-9 b with initial atmospheric mass fractions ranging from 2-100%, we find that this planet could not have retained a primordial H/He atmosphere beyond the first 200 Myr of its lifetime. Follow-up MIRI eclipse observations at 15 microns could make it possible to confidently identify a CO2-dominated atmosphere on this planet if one exists., Comment: 19 pages, 11 figures, accepted for publication in The Astronomical Journal

We present 850 $\mu$m polarization observations of the IC 348 star-forming region in the Perseus molecular cloud as part of the B-fields In STar-forming Region Observation (BISTRO) survey. We study the magnetic properties of two cores (HH 211 MMS and IC 348 MMS) and a filamentary structure of IC 348. We find that the overall field tends to be more perpendicular than parallel to the filamentary structure of the region. The polarization fraction decreases with intensity, and we estimate the trend by power-law and the mean of the Rice distribution fittings. The power indices for the cores are much smaller than 1, indicative of possible grain growth to micron size in the cores. We also measure the magnetic field strengths of the two cores and the filamentary area separately by applying the Davis-Chandrasekhar-Fermi method and its alternative version for compressed medium. The estimated mass-to-flux ratios are 0.45-2.20 and 0.63-2.76 for HH 211 MMS and IC 348 MMS, respectively, while the ratios for the filament is 0.33-1.50. This result may suggest that the transition from subcritical to supercritical conditions occurs at the core scale ($\sim$ 0.05 pc) in the region. In addition, we study the energy balance of the cores and find that the relative strength of turbulence to the magnetic field tends to be stronger for IC 348 MMS than HH 211 MMS. The result could potentially explain the different configurations inside the two cores: a single protostellar system in HH 211 MMS and multiple protostars in IC 348 MMS., Comment: Accepted for publication in ApJ. 21 pages, 12 figures

We formulate and analyze interior penalty discontinuous Galerkin methods for coupled elliptic PDEs modeling excitable tissue, represented by intracellular and extracellular domains sharing a common interface. The PDEs are coupled through a dynamic boundary condition, posed on the interface, that relates the normal gradients of the solutions to the time derivative of their jump. This system is referred to as the Extracellular Membrane Intracellular model or the cell-by-cell model. Due to the dynamic nature of the interface condition and to the presence of corner singularities, the analysis of discontinuous Galerkin methods is non-standard. We prove the existence and uniqueness of solutions by a reformulation of the problem to one posed on the membrane. Convergence is shown by utilizing face-to-element lifting operators and notions of weak consistency suitable for solutions with low spatial regularity. Further, we present parameter-robust preconditioned iterative solvers. Numerical examples in idealized geometries demonstrate our theoretical findings, and simulations in multiple cells portray the robustness of the method.

In molecular systems, the ultrafast motion of electrons initiates the process of chemical change. Tracking this electronic motion across molecules requires coupling attosecond time resolution to atomic-scale spatial sensitivity. In this work, we employ a pair of attosecond x-ray pulses from an x-ray free-electron laser to follow electron motion resulting from the sudden removal of an electron from a prototypical aromatic system, para-aminophenol. X-ray absorption enables tracking this motion with atomic-site specificity. Our measurements are compared with state-of-the-art computational modeling, reproducing the observed response across multiple timescales. Sub-femtosecond dynamics are assigned to states undergoing non-radiative decay, while few-femtosecond oscillatory motion is associated with electronic wavepacket motion in stable cation states, that will eventually couple to nuclear motion. Our work provides insight on the ultrafast charge motion preceding and initiating chemical transformations in moderately complex systems, and provides a powerful benchmark for computational models of ultrafast charge motion in matter.

Motivated by recently observed anomalies in the flavour sector, we analyse the potential of measurements of top quarks at the Large Hadron Collider (LHC) to provide complementary constraints on interactions that shape low-energy precision investigations in the $B$ sector. The measurement of top quark properties, such as the top width and the abundant top pair production channels, are already reaching the percent level at this relatively early stage of the LHC phenomenology program. A focused analysis of four-fermion interactions, employing effective field theory without flavour structure assumptions and incorporating renormalization group evolution effects, bridges $B$ meson scale phenomena with key top quark measurements. We demonstrate that the LHC is increasingly competitive with, and complementary to, flavour physics constraints. Our results, which include a first comprehensive analysis of non-leptonic B decays in this context, suggest that the LHC's top physics program could serve as a valuable, complementary tool in the search for physics beyond the Standard Model within the flavour sector., Comment: 8 pages, 3 figures, 1 table. v2: Added references and small improvements to the discussion

Motivated by our collaboration with a major refugee resettlement agency in the U.S., we study a dynamic matching problem where each new arrival (a refugee case) must be matched immediately and irrevocably to one of the static resources (a location with a fixed annual quota). In addition to consuming the static resource, each case requires post-allocation service from a server, such as a translator. Given the time-consuming nature of service, a server may not be available at a given time, thus we refer to it as a dynamic resource. Upon matching, the case will wait to avail service in a first-come-first-serve manner. Bursty matching to a location may result in undesirable congestion at its corresponding server. Consequently, the central planner (the agency) faces a dynamic matching problem with an objective that combines the matching reward (captured by pair-specific employment outcomes) with the cost for congestion for dynamic resources and over-allocation for the static ones. Motivated by the observed fluctuations in the composition of refugee pools across the years, we design algorithms that do not rely on distributional knowledge constructed based on past years' data. To that end, we develop learning-based algorithms that are asymptotically optimal in certain regimes, easy to interpret, and computationally fast. Our design is based on learning the dual variables of the underlying optimization problem; however, the main challenge lies in the time-varying nature of the dual variables associated with dynamic resources. To overcome this challenge, our theoretical development brings together techniques from Lyapunov analysis, adversarial online learning, and stochastic optimization. On the application side, when tested on real data from our partner agency, our method outperforms existing ones making it a viable candidate for replacing the current practice upon experimentation., Comment: Preliminary conference version appeared in ACM Economics and Computation (EC 2024)

This letter presents a dual quadrature phasemeter, an implementation of a phase-locked loop designed to track the phase of homodyne and heterodyne inter-satellite laser links. The dual quadrature phasemeters use dual quadrature optical detection to enable an alternate phase readout scheme that operates with wider bandwidths and on signals with carrier frequency differences down to DC. Analytical modeling demonstrates that dual quadrature phasemeters overcome the bandwidth limitations of conventional phasemeters. Numerical simulations of noise linearity tests found that the phase tracking error of the dual quadrature phasemeter is less than 10 microcycle/$\sqrt{\text{Hz}}$ in the presence of non-linear cyclic errors. The dual quadrature phasemeter enables exploration of a new optical configuration for retroreflector-based space geodesy missions with architecture similar to that implemented in GRACE-FO. One such alternate configuration is proposed that is capable of tracking satellite separation without requiring a frequency offset between local and incoming light, eliminating the need for optical frequency shifters.

Heteroclinic cycles and networks are structures in dynamical systems composed of invariant sets and connecting heteroclinic orbits, and can be robust in systems with invariant subspaces. The usual method for analysing the stability of heteroclinic cycles and networks is to construct return maps to cross-sections near the network. From these return maps, transition matrices can be defined, whose eigenvalues and eigenvectors can be analysed to determine stability. In this paper, we introduce an extension to this methodology, the projected map, which we define by identifying trajectories with, in a certain sense, qualitatively the same dynamics. The projected map is a discrete, piecewise-smooth map of one dimension one fewer than the rank of the transition matrix. We use these maps to describe the dynamics of trajectories near three heteroclinic networks in $\mathbb{R}^{4}$ with four equilibria. We find in all three cases that the onset of trajectories that switch between cycles of the network can be caused by a fold bifurcation or border-collision bifurcation, where fixed points of the map no longer exist in the corresponding function's domain of definition. We are able to show that trajectories near these three networks are asymptotic to only one subcycle, and cannot switch between subcycles multiple times, in contrast to examples with more than four equilibria, and resolving a 30-year-old claim by Brannath. We are also able to generalise some results to all quasi-simple networks, showing that a border-collision bifurcation of the projected map, corresponding to a condition on the eigenvectors of certain transition matrices, causes a cycle to lose stability.

The XLZD collaboration is developing a two-phase xenon time projection chamber with an active mass of 60 to 80 t capable of probing the remaining WIMP-nucleon interaction parameter space down to the so-called neutrino fog. In this work we show that, based on the performance of currently operating detectors using the same technology and a realistic reduction of radioactivity in detector materials, such an experiment will also be able to competitively search for neutrinoless double beta decay in $^{136}$Xe using a natural-abundance xenon target. XLZD can reach a 3$\sigma$ discovery potential half-life of 5.7$\times$10$^{27}$ yr (and a 90% CL exclusion of 1.3$\times$10$^{28}$ yr) with 10 years of data taking, corresponding to a Majorana mass range of 7.3-31.3 meV (4.8-20.5 meV). XLZD will thus exclude the inverted neutrino mass ordering parameter space and will start to probe the normal ordering region for most of the nuclear matrix elements commonly considered by the community., Comment: 29 pages, 7 figures

We investigate the different transport mechanisms that can occur in atomically precise advanced-manufacturing (APAM) pn junction devices at cryogenic and room temperatures. We first elucidate the potential cause of the anomalous behaviors observed in the forward-bias response of these devices in recent cryogenic temperature measurements, which deviates from the theoretical response of a silicon Esaki diode. Specifically, the suppression of the tunneling current at low bias and the appearance of regular diode current at lower biases than theoretically expected for silicon. We find that the latter can be attributed to modifications in the electronic band structure within the $\delta$-layer regions, leading to band-gap narrowing induced by the high density of dopants. We also find that a combination of two sets of band-to-band tunneling (BTBT) parameters can qualitatively approximate the shape of the tunneling current at low bias. This can arise from band quantization and realignment due to the strong potential confinement in APAM-doped layers. Finally, we extend our analyses to room temperature operation, and we predict that trap-assisted tunneling (TAT) may become significant, leading to a complex superposition of BTBT and TAT transport mechanisms in the electrical measurements.

In condensed-matter physics, supersolids refer to many-body quantum states breaking translational symmetry while exhibiting off-diagonal long-range order. This combination is debated for commensurate crystals, however it is accessible in lattice potentials fractionally filled by bosons with extended interactions. Here, we report such lattice supersolid with dipolar excitons confined in a sub-wavelength period potential. Excitons implement the Dicke-Hubbard Hamiltonian controlled by spatially extended dipolar and Dicke correlations. At half lattice-filling, these induce both a condensation in a single sub-radiant state and a dipolar quantum order spontaneously breaking the lattice symmetry. This combination signals a lattice supersolid dissipatively prepared across 8x8 sites. Our study underlines that nanoscopic exciton arrays open a route to explore new frontiers of quantum matter, e.g. many-body entanglement, at the interface with quantum nano-photonics., Comment: 12 pages, 7 figures

This report describes the experimental strategy and technologies for a next-generation xenon observatory sensitive to dark matter and neutrino physics. The detector will have an active liquid xenon target mass of 60-80 tonnes and is proposed by the XENON-LUX-ZEPLIN-DARWIN (XLZD) collaboration. The design is based on the mature liquid xenon time projection chamber technology of the current-generation experiments, LZ and XENONnT. A baseline design and opportunities for further optimization of the individual detector components are discussed. The experiment envisaged here has the capability to explore parameter space for Weakly Interacting Massive Particle (WIMP) dark matter down to the neutrino fog, with a 3$\sigma$ evidence potential for the spin-independent WIMP-nucleon cross sections as low as $3\times10^{-49}\rm cm^2$ (at 40 GeV/c$^2$ WIMP mass). The observatory is also projected to have a 3$\sigma$ observation potential of neutrinoless double-beta decay of $^{136}$Xe at a half-life of up to $5.7\times 10^{27}$ years. Additionally, it is sensitive to astrophysical neutrinos from the atmosphere, sun, and galactic supernovae., Comment: 32 pages, 14 figures

Radio interferometry is an observational technique used to study astrophysical phenomena. Data gathered by an interferometer requires substantial processing before astronomers can extract the scientific information from it. Data processing consists of a sequence of calibration and analysis procedures where choices must be made about the sequence of procedures as well as the specific configuration of the procedure itself. These choices are typically based on a combination of measurable data characteristics, an understanding of the instrument itself, an appreciation of the trade-offs between compute cost and accuracy, and a learned understanding of what is considered "best practice". A metric of absolute correctness is not always available and validity is often subject to human judgment. The underlying principles and software configurations to discern a reasonable workflow for a given dataset is the subject of training workshops for students and scientists. Our goal is to use objective metrics that quantify best practice, and numerically map out the decision space with respect to our metrics. With these objective metrics we demonstrate an automated, data-driven, decision system that is capable of sequencing the optimal action(s) for processing interferometric data. This paper introduces a simplified description of the principles behind interferometry and the procedures required for data processing. We highlight the issues with current automation approaches and propose our ideas for solving these bottlenecks. A prototype is demonstrated and the results are discussed., Comment: 22 pages, 13 figures; accepted for publication in The Astronomical Journal October 18, 2024

We report results of a search for nuclear recoils induced by weakly interacting massive particle (WIMP) dark matter using the LUX-ZEPLIN (LZ) two-phase xenon time projection chamber. This analysis uses a total exposure of $4.2\pm0.1$ tonne-years from 280 live days of LZ operation, of which $3.3\pm0.1$ tonne-years and 220 live days are new. A technique to actively tag background electronic recoils from $^{214}$Pb $\beta$ decays is featured for the first time. Enhanced electron-ion recombination is observed in two-neutrino double electron capture decays of $^{124}$Xe, representing a noteworthy new background. After removal of artificial signal-like events injected into the data set to mitigate analyzer bias, we find no evidence for an excess over expected backgrounds. World-leading constraints are placed on spin-independent (SI) and spin-dependent WIMP-nucleon cross sections for masses $\geq$9 GeV/$c^2$. The strongest SI exclusion set is $2.1\times10^{-48}$ cm$^{2}$ at the 90% confidence level at a mass of 36 GeV/$c^2$, and the best SI median sensitivity achieved is $5.0\times10^{-48}$ cm$^{2}$ for a mass of 40 GeV/$c^2$., Comment: 9 pages, 7 figures. See https://www.hepdata.net/record/155182 for a data release related to this paper

Observations suggest that filaments in molecular clouds can grow by mass accretion while forming cores via fragmentation. Here we present one of the first large sample studies of filament accretion using velocity gradient measurements of star-forming filaments on the $\sim 0.05$ pc scale with NH$_3$ observations of the Perseus Molecular Cloud, primarily obtained as a part of the GBT Ammonia Survey (GAS). In this study, we find significant correlations between velocity gradient, velocity dispersion, mass per unit length, and the number of cores per unit length of the Perseus filaments. Our results suggest a scenario in which filaments not only grow through mass accretion but also form new cores continuously in the process well into the thermally supercritical regime. Such behavior is contrary to that expected from isolated filament models but consistent with how filaments form within a more realistic cloud environment, suggesting that the cloud environment plays a crucial role in shaping core formation and evolution in filaments. Furthermore, even though velocity gradients within filaments are not oriented randomly, we find no correlation between velocity gradient orientation and the filament properties we analyzed. This result suggests that gravity is unlikely the dominant mechanism imposing order on the $\sim 0.05$ pc scale for dense star-forming gas., Comment: Accepted to ApJ (Oct 17, 2024)

Recovering a spectrum of diverse policies from a set of expert trajectories is an important research topic in imitation learning. After determining a latent style for a trajectory, previous diverse policies recovering methods usually employ a vanilla behavioral cloning learning objective conditioned on the latent style, treating each state-action pair in the trajectory with equal importance. Based on an observation that in many scenarios, behavioral styles are often highly relevant with only a subset of state-action pairs, this paper presents a new principled method in diverse polices recovery. In particular, after inferring or assigning a latent style for a trajectory, we enhance the vanilla behavioral cloning by incorporating a weighting mechanism based on pointwise mutual information. This additional weighting reflects the significance of each state-action pair's contribution to learning the style, thus allowing our method to focus on state-action pairs most representative of that style. We provide theoretical justifications for our new objective, and extensive empirical evaluations confirm the effectiveness of our method in recovering diverse policies from expert data., Comment: 18 pages, 6 figures

We discuss a novel and simple parametrisation of the pion vector form factor that transparently connects spacelike and timelike regions of the momentum transfer $q^2$. Our parametrisation employs the framework of conformal mapping and respects the known analyticity properties of the form factor, accounting explicitly for the $\rho(770)$-meson pole. The parametrisation manifestly fulfils the normalisation condition at $q^2 = 0$ as well as further restrictions at the pion production threshold and in the limit $|q^2| \to \infty$. In contrast to the widely used Omn\`es parametrisation, our approach does not use the pion-pion scattering phase shift as input. We confront the parametrisation with experimental data from $\pi H$ scattering and $\tau^- \to \pi^-\pi^0\nu$ decay. We already find a good description of the data with only five free parameters, which include the pole mass and decay width of the $\rho(770)$., Comment: 4 pages, 1 figure, 1 table

It is generally assumed that existing artificial systems are not phenomenally conscious, and that the construction of phenomenally conscious artificial systems would require significant technological progress if it is possible at all. We challenge this assumption by arguing that if Global Workspace Theory (GWT) - a leading scientific theory of phenomenal consciousness - is correct, then instances of one widely implemented AI architecture, the artificial language agent, might easily be made phenomenally conscious if they are not already. Along the way, we articulate an explicit methodology for thinking about how to apply scientific theories of consciousness to artificial systems and employ this methodology to arrive at a set of necessary and sufficient conditions for phenomenal consciousness according to GWT.

The propagation of wave fields and their interactions with matter are important for established and emerging fields in optical sciences. Efficient methods for predicting such behaviour have been employed routinely for coherent sources. However, most real world optical systems exhibit partial coherence, for which the present mathematical description involves high dimensional complex functions and hence poses challenges for numerical implementations. This demands significant computational resources to determine the properties of partially coherent wavefields. Here, we describe the novel Phase-Space (PS) propagator, an efficient and self-consistent technique for free space propagation of wave fields which are partially coherent in the spatial domain. The PS propagator makes use of the fact that the propagation of a wave field in free space is equivalent to a shearing of the corresponding PSD function. Computationally, this approach is simpler and the need for using different propagation methods for near and far-field regions is removed., Comment: 17 pages, 4 figures, to be submitted to Optics Communications For the associated Python package, see https://github.com/jakerogers-1/Phase-Space-Propagator

We present a transmission spectrum of the misaligned hot Jupiter WASP-15b from 2.8--5.2 microns observed with JWST's NIRSpec/G395H grating. Our high signal to noise data, which has negligible red noise, reveals significant absorption by H$_2$O ($4.2\sigma$) and CO$_2$ ($8.9\sigma$). From independent data reduction and atmospheric retrieval approaches, we infer that WASP-15b's atmospheric metallicity is super-solar ($\gtrsim 15\times$ solar) and its C/O is consistent with solar, that together imply planetesimal accretion. Our GCM simulations for WASP-15b suggest that the C/O we measure at the limb is likely representative of the entire photosphere due to the mostly uniform spatial distribution of H$_2$O, CO$_2$ and CO. We additionally see evidence for absorption by SO$_2$ and absorption at 4.9$\mu$m, for which the current leading candidate is OCS, albeit with several caveats. If confirmed, this would be the first detection of OCS in an exoplanet atmosphere and point towards complex photochemistry of sulphur-bearing species in the upper atmosphere. These are the first observations from the BOWIE-ALIGN survey which is using JWST's NIRSpec/G395H instrument to compare the atmospheric compositions of aligned/low-obliquity and misaligned/high-obliquity hot Jupiters around F stars above the Kraft break. The goal of our survey is to determine whether the atmospheric composition differs across two populations of planets that have likely undergone different migration histories (disc versus disc-free) as evidenced by their obliquities (aligned versus misaligned)., Comment: 24 pages, 23 figures, 6 tables. Submitted to MNRAS

There has been a growing trend that activities relating to clinical trials take place at locations other than traditional trial sites (hence decentralized clinical trials or DCTs), some of which are at settings of real-world clinical practice. Although there are numerous benefits of DCTs, this also brings some implications on a number of issues relating to the design, conduct, and analysis of DCTs. The Real-World Evidence Scientific Working Group of the American Statistical Association Biopharmaceutical Section has been reviewing the field of DCTs and provides in this paper considerations for decentralized trials from a statistical perspective. This paper first discusses selected critical decentralized elements that may have statistical implications on the trial and then summarizes regulatory guidance, framework, and initiatives on DCTs. More discussions are presented by focusing on the design (including construction of estimand), implementation, statistical analysis plan (including missing data handling), and reporting of safety events. Some additional considerations (e.g., ethical considerations, technology infrastructure, study oversight, data security and privacy, and regulatory compliance) are also briefly discussed. This paper is intended to provide statistical considerations for decentralized trials of medical products to support regulatory decision-making.

Job interviews play a critical role in shaping one's career, yet practicing interview skills can be challenging, especially without access to human coaches or peers for feedback. Recent advancements in large language models (LLMs) present an opportunity to enhance the interview practice experience. Yet, little research has explored the effectiveness and user perceptions of such systems or the benefits and challenges of using LLMs for interview practice. Furthermore, while prior work and recent commercial tools have demonstrated the potential of AI to assist with interview practice, they often deliver one-way feedback, where users only receive information about their performance. By contrast, dialogic feedback, a concept developed in learning sciences, is a two-way interaction feedback process that allows users to further engage with and learn from the provided feedback through interactive dialogue. This paper introduces Conversate, a web-based application that supports reflective learning in job interview practice by leveraging large language models (LLMs) for interactive interview simulations and dialogic feedback. To start the interview session, the user provides the title of a job position (e.g., entry-level software engineer) in the system. Then, our system will initialize the LLM agent to start the interview simulation by asking the user an opening interview question and following up with questions carefully adapted to subsequent user responses. After the interview session, our back-end LLM framework will then analyze the user's responses and highlight areas for improvement. Users can then annotate the transcript by selecting specific sections and writing self-reflections. Finally, the user can interact with the system for dialogic feedback, conversing with the LLM agent to learn from and iteratively refine their answers based on the agent's guidance.

We explore strategies aimed at reducing the amount of computation, both quantum and classical, required to run the Quantum Approximate Optimization Algorithm (QAOA). First, following Wurtz et al. [Phys.Rev A 104:052419], we consider the standard QAOA with instance-independent "tree" parameters chosen in advance. These tree parameters are chosen to optimize the MaxCut expectation for large girth graphs. We provide extensive numerical evidence supporting the performance guarantee for tree parameters conjectured in [Phys.Rev A 103:042612] and see that the approximation ratios obtained with tree parameters are typically well beyond the conjectured lower bounds, often comparable to performing a full optimization. This suggests that in practice, the QAOA can achieve near-optimal performance without the need for parameter optimization. Next, we modify the warm-start QAOA of Tate et al. [Quantum 7:1121]. The starting state for the QAOA is now an optimized product state associated with a solution of the Goemans-Williamson (GW) algorithm. Surprisingly, the tree parameters continue to perform well for the warm-start QAOA. We find that for random 3-regular graphs with hundreds of vertices, the expected cut obtained by the warm-start QAOA at depth $p \gtrsim 3$ is comparable to that of the standard GW algorithm. Our numerics on random instances do not provide general performance guarantees but do provide substantial evidence that there exists a regime of instance sizes in which the QAOA finds good solutions at low depth without the need for parameter optimization. For each instance studied, we classically compute the expected size of the QAOA distribution of cuts; producing the actual cuts requires running on a quantum computer., Comment: 15 pages, 4 figures

The local (z=0.0315) AGN Mrk 817, was monitored over more than 500 days with space-borne and ground-based instruments as part of a large international campaign AGN STORM 2. Here, we present a comprehensive analysis of the broad-band continuum variations using detailed modeling of the broad line region (BLR), several types of disk winds classified by their optical depth, and new numerical simulations. We find that diffuse continuum (DC) emission, with additional contributions from strong and broad emission lines, can explain the continuum lags observed in this source during high and low luminosity phases. Disk illumination by the variable X-ray corona contributes only a small fraction of the observed continuum lags. Our BLR models assume radiation pressure-confined clouds distributed over a distance of 2-122 light days. We present calculated mean-emissivity radii of many emission lines, and DC emission, and suggest a simple, transfer-function-dependent method that ties them to cross-correlation lag determinations. We do not find clear indications for large optical depth winds but identify the signature of lower column density winds. In particular, we associate the shortest observed continuum lags with a combination of tau(1 Ryd) approx. 2 wind and a partly shielded BLR. Even smaller optical depth winds may be associated with X-ray absorption features and with noticeable variations in the width and lags of several high ionization lines like HeII and CIV. Finally, we demonstrate the effect of torus dust emission on the observed lags in the i and z bands., Comment: 23 pages, 18 figures. Corrected typographical error in the title of the paper as it appeared in the Metadata