Search

Your search keyword '"A. López-Guillermo"' showing total 3,048 results
Start Over Author "A. López-Guillermo"
3,048 results on '"A. López-Guillermo"'

1. P631: A PCR-BASED ASSAY FOR IGLV3-21R110 SCREENING CONFIRMS ITS PROGNOSTIC VALUE IN AN INDEPENDENT COHORT OF 613 PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA.

Author

C. Syrykh, N. Russiñol, T. Baumann, M. Kulis, M. Alcoceba, M. González, E. Colado, Á. R. Payer, M. Aymerich, M. J. Terol, S. Ruiz-Gaspà, A. López-Guillermo, J. I. Martín-Subero, D. Colomer, J. Delgado, E. Campo, and F. Nadeu

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2022
Full Text
View/download PDF

2. P1198: ASSOCIATION OF PRETREATMENT TUMOR CHARACTERISTICS AND CLINICAL OUTCOMES FOLLOWING SECOND-LINE AXICABTAGENE CILOLEUCEL VS STANDARD OF CARE IN PATIENTS WITH RELAPSED/REFRACTORY LARGE B-CELL LYMPHOMA

Author

F. L. Locke, J. Chou, S. Vardhanabhuti, R. Perbost, P. Dreger, B. T. Hill, C. Lee, P. L. Zinzani, N. Kröger, A. López-Guillermo, H. Greinix, W. Zhang, G. Tiwari, C. To, P. Cheng, A. Bot, R. Shen, S. Filosto, and J. Galon

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2022
Full Text
View/download PDF

3. P1260: UNRAVELING THE GENETICS OF TRANSFORMED SPLENIC MARGINAL ZONE LYMPHOMA

Author

M. Grau, C. López, A. Navarro, G. Clot, F. Nadeu, G. Bastidas, M. Alcoceba, M. J. Baptista, M. Blanes, F. Climent, D. Colomer, D. Costa, E. Domingo-Domènech, P. Forcada, A. Enjuanes, L. Escoda, G. Frigola, E. Giné, M. Lopez-Guerra, A. Rivas-Delgado, L. Vicente-Folch, A. Wotherspoon, E. Campo, A. López-Guillermo, E. Matutes, and S. Beà

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2022
Full Text
View/download PDF

4. P1282: DISEASE-SPECIFIC U1 SPLICEOSOMAL RNA MUTATIONS IN MATURE B-CELL NEOPLASMS

Author

F. Nadeu, S. Shuai, G. Clot, L. K. Hilton, A. Diaz-Navarro, S. Martín, R. Royo, T. Baumann, M. Kulis, I. López-Oreja, M. Cossio, J. Lu, V. Ljungström, E. Young, K. Plevova, B. A. Knisbacher, Z. Lin, C. K. Hahn, P. Bousquets, M. Alcoceba, M. González, E. Colado, M. Aymerich, M. J. Terol, A. Rivas-Delgado, A. Enjuanes, S. Ruiz-Gaspà, T. Chatzikonstantinou, D. Hägerstrand, C. Jylhä, A. Skaftason, L. Mansouri, K. Stranska, M. Doubek, E. J. van Gastel-Mol, Z. Davis, R. Walewska, L. Scarfò, L. Trentin, A. Visentin, S. A. Parikh, K. G. Rabe, R. Moia, M. Armand, D. Rossi, F. Davi, G. Gaidano, N. E. Kay, T. Shanafelt, P. Ghia, D. Oscier, A. W. Langerak, S. Beà, A. López-Guillermo, D. Neuberg, C. J. Wu, G. Getz, S. Pospisilova, K. Stamatopoulos, R. Rosenquist, W. Huber, T. Zenz, D. Colomer, J. I. Martín-Subero, J. Delgado, R. D. Morin, L. D. Stein, X. S. Puente, and E. Campo

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2022
Full Text
View/download PDF

5. P1277: MUTATIONAL LANDSCAPE AND COPY NUMBER ALTERATIONS IN TESTICULAR LARGE B-CELL LYMPHOMA

Author

C. López, A. Rivas-Delgado, F. Nadeu, M. Grau, A. Rivero, J. Boschs-Schips, M. Alcoceba, G. Tapia, L. Luizaga, C. Bárcena, N. Kelleher, M. Pablo, O. Balague, G. Frigola, N. Villamor, L. Magnano, T. Baumann, A. Muntañola, J. M. Sancho-Cia, A. M. García-Sancho, E. Gonzalez Barca, F. Climent, E. Campo, E. Giné, A. López-Guillermo, and S. Beà

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2022
Full Text
View/download PDF

6. PB2088: IMMUNE PROFILE OF PATIENTS WITH FOLLICULAR LYMPHOMA ASSESSED BY FLOW CYTOMETRY IN PERIPHERAL BLOOD: CHARACTERISTICS AT DIAGNOSIS AND AT RELAPSE OF THE DISEASE

Author

A. Rivero Arango, P. Mozas, J. Correa, A. Rivas-Delgado, F. Araujo-Ayala, K. Guinetti, A. Bataller, M. Condom, A. Gaya, J. Delgado, E. Giné, P. Perez-Galán, E. Campo, A. Vlagea, E. Matutes, A. López-Guillermo, N. Villamor, and L. Magnano

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2022
Full Text
View/download PDF

9. Patient-derived follicular lymphoma spheroids recapitulate lymph node signaling and immune profile uncovering galectin-9 as a novel immunotherapeutic target

Author

Dobaño-López, Cèlia, Valero, Juan García, Araujo-Ayala, Ferran, Nadeu, Ferran, Gava, Fabien, Faria, Carla, Norlund, Marine, Morin, Renaud, Bernes-Lasserre, Pascale, Arenas, Fabian, Grau, Marta, López, Cristina, López-Oreja, Irene, Serrat, Neus, Martínez-Farran, Ares, Hernández, Lluís, Playa-Albinyana, Heribert, Giménez, Rubén, Beà, Silvia, Campo, Elías, Lagarde, Jean-Michel, López-Guillermo, Armando, Magnano, Laura, Colomer, Dolors, Bezombes, Christine, and Pérez-Galán, Patricia

Published
2024
Full Text
View/download PDF

10. Long-term surveillance of the feline leukemia virus in the endangered Iberian lynx (Lynx pardinus) in Andalusia, Spain (2008–2021)

Author

Nájera, Fernando, López, Guillermo, del Rey-Wamba, Tere, Malik, Rimsha A., Garrote, Germán, López-Parra, Marcos, Fernández-Pena, Leonardo, García-Tardío, Maribel, Arenas-Rojas, Rafael, Simón, Miguel A., Zorrilla, Irene, Fernández, Isabel, Alcaide, Eva M., Ruiz, Carmen, Revuelta, Luis, Salcedo, Javier, Hofmann-Lehmann, Regina, and Meli, Marina L.

Published
2024
Full Text
View/download PDF

11. The genomic landscape of transformed splenic diffuse red pulp small B‐cell lymphoma

Author

Marta Grau, Melina Pol, Anna Montaner, Pablo Mozas, Ferran Nadeu, Ian Márquez‐López, Jose Ramon Álamo, Alba Navarro, Daniel Martinez, Gerard Frigola, Olga Balagué, Mónica Lopez‐Guerra, Dolors Colomer, Silvia Ruiz‐Gaspà, Melika Bashiri, Juan Correa, Eva Giné, Armando López‐Guillermo, Elias Campo, Cristina López, Estella Matutes, and Sílvia Beà

Subjects
B‐cell developement, cell cycle, clonal relationship, genetic alterations, histologic transformation, splenic diffuse red pulp small B‐cell lymphoma, Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Abstract The genetic landscape underlying the transformation of splenic diffuse red pulp small B‐cell lymphoma (SDRPL) is not well understood. The present study aimed to unravel the genomic alterations involved in the progression and transformation of SDRPL. We performed genetic studies on both SDRPL and subsequent or synchronous diffuse large B cell lymphoma (DLBCL) samples in three SDRPL patients who eventually developed DLBCL. Our findings revealed that SDRPL cases progressing to DLBCL acquired genomic alterations in genes related to the cell cycle (CDKN2A/B, TP53, MYC and CCND3) and B cell development (BCL6).

Published
2024
Full Text
View/download PDF

13. Testicular large B‐cell lymphoma is genetically similar to PCNSL and distinct from nodal DLBCL

Author

Alfredo Rivas‐Delgado, Cristina López, Guillem Clot, Ferran Nadeu, Marta Grau, Gerard Frigola, Jan Bosch‐Schips, Josefine Radke, Naveed Ishaque, Miguel Alcoceba, Gustavo Tapia, Luis Luizaga, Carmen Barcena, Nicholas Kelleher, Neus Villamor, Tycho Baumann, Ana Muntañola, Juan M. Sancho‐Cia, Alejandro M. García‐Sancho, Eva Gonzalez‐Barca, Estella Matutes, Jordi A. Brito, Kennosuke Karube, Itziar Salaverria, Anna Enjuanes, Stefan Wiemann, Frank L. Heppner, Reiner Siebert, Fina Climent, Elías Campo, Eva Giné, Armando López‐Guillermo, and Silvia Beà

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Abstract Testicular large B‐cell lymphoma (TLBCL) is an infrequent and aggressive lymphoma arising in an immune‐privileged site and has recently been recognized as a distinct entity from diffuse large B‐cell lymphoma (DLBCL). We describe the genetic features of TLBCL and compare them with published series of nodal DLBCL and primary large B‐cell lymphomas of the CNS (PCNSL). We collected 61 patients with TLBCL. We performed targeted next‐generation sequencing, copy number arrays, and fluorescent in situ hybridization to assess chromosomal rearrangements in 40 cases with available material. Seventy percent of the cases showed localized stages. BCL6 rearrangements were detected in 36% of cases, and no concomitant BCL2 and MYC rearrangements were found. TLBCL had fewer copy number alterations (p

Published
2024
Full Text
View/download PDF

14. Impact of tumor microenvironment on efficacy of anti-CD19 CAR T cell therapy or chemotherapy and transplant in large B cell lymphoma

Author

Locke, Frederick L., Filosto, Simone, Chou, Justin, Vardhanabhuti, Saran, Perbost, Regis, Dreger, Peter, Hill, Brian T., Lee, Catherine, Zinzani, Pier L., Kröger, Nicolaus, López-Guillermo, Armando, Greinix, Hildegard, Zhang, Wangshu, Tiwari, Gayatri, Budka, Justin, Marincola, Francesco M., To, Christina, Mattie, Mike, Schupp, Marco, Cheng, Paul, Bot, Adrian, Shen, Rhine, Bedognetti, Davide, Miao, Harry, and Galon, Jérôme

Published
2024
Full Text
View/download PDF

16. Patient-derived follicular lymphoma spheroids recapitulate lymph node signaling and immune profile uncovering galectin-9 as a novel immunotherapeutic target

Author

Cèlia Dobaño-López, Juan García Valero, Ferran Araujo-Ayala, Ferran Nadeu, Fabien Gava, Carla Faria, Marine Norlund, Renaud Morin, Pascale Bernes-Lasserre, Fabian Arenas, Marta Grau, Cristina López, Irene López-Oreja, Neus Serrat, Ares Martínez-Farran, Lluís Hernández, Heribert Playa-Albinyana, Rubén Giménez, Silvia Beà, Elías Campo, Jean-Michel Lagarde, Armando López-Guillermo, Laura Magnano, Dolors Colomer, Christine Bezombes, and Patricia Pérez-Galán

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Follicular lymphoma (FL), the most common indolent non-Hodgkin lymphoma, constitutes a paradigm of immune tumor microenvironment (TME) contribution to disease onset, progression, and heterogenous clinical outcome. Here we present the first FL-Patient Derived Lymphoma Spheroid (FL-PDLS), including fundamental immune actors and features of TME in FL lymph nodes (LNs). FL-PDLS is organized in disc-shaped 3D structures composed of proliferating B and T cells, together with macrophages with an intermediate M1/M2 phenotype. FL-PDLS recapitulates the most relevant B-cell transcriptional pathways present in FL-LN (proliferation, epigenetic regulation, mTOR, adaptive immune system, among others). The T cell compartment in the FL-PDLS preserves CD4 subsets (follicular helper, regulatory, and follicular regulatory), also encompassing the spectrum of activation/exhaustion phenotypes in CD4 and CD8 populations. Moreover, this system is suitable for chemo and immunotherapy testing, recapitulating results obtained in the clinic. FL-PDLS allowed uncovering that soluble galectin-9 limits rituximab, rituximab, plus nivolumab/TIM-3 antitumoral activities. Blocking galectin-9 improves rituximab efficacy, highlighting galectin-9 as a novel immunotherapeutic target in FL. In conclusion, FL-PDLS maintains the crosstalk between malignant B cells and the immune LN-TME and constitutes a robust and multiplexed pre-clinical tool to perform drug screening in a patient-derived system, advancing toward personalized therapeutic approaches.

Published
2024
Full Text
View/download PDF

21. Modelling of saturated external MHD instabilities in tokamaks: a comparison of 3D free boundary equilibria and nonlinear stability calculations

Author

Ramasamy, Rohan, Ramirez, Guillermo Bustos, Hoelzl, Matthias, Graves, Jonathan, López, Guillermo Suárez, Lackner, Karl, Günter, Sibylle, and team, the JOREK

Subjects
Physics - Plasma Physics
Abstract

3D free boundary equilibrium computations have recently been used to model external kinks and edge harmonic oscillations (EHOs), comparing with linear MHD stability codes, and nonlinear analytic theory [Kleiner et al, PPCF 61 084005 (2019)]. In this study, results of the VMEC equilibrium code are compared further with nonlinear reduced MHD simulations, using the JOREK code. The purpose of this investigation is to understand the extent to which the modelling approaches agree, and identify the important physical effects which can modify the dynamics. For the simulated external kink, which is dominated by a single toroidal harmonic, good agreement is found when a large Lundquist number is used in the JOREK simulation, such that resistive effects are sub-dominant. Modelling EHOs where multiple toroidal harmonics are linearly unstable, the saturated perturbation observed can differ in the dominant toroidal harmonic. On the ideal timescale, a n=2 EHO is observed in JOREK, while the saturated perturbation predicted by VMEC is a n=1 mode. Extending simulations into timescales where resistive effects can play a role, similar n=1 perturbations can be found. The coupling of different linearly unstable toroidal harmonics in the JOREK simulation broadens the magnetic energy spectrum and ergodises the plasma edge region, resulting in a more localised pressure perturbation. These effects are not observed in VMEC, because closed magnetic flux surfaces are enforced. Despite the sensitivity of JOREK results on the assumed resistivity, saturated states can be found using both approaches that are in reasonable agreement, even for this more advanced case., Comment: Submitted to Physics of Plasmas, with revisions from review process included

Published
2022
Full Text
View/download PDF

23. Impacto de la guardia de cardiología en el tratamiento de reperfusión de los pacientes con IAMCEST en un centro de segundo nivel

Author

Santás Álvarez, Melisa, Bayón Lorenzo, Jeremías, Aldama López, Guillermo, Paredes Galán, Emilio, Abellás Sequeiros, Rosa Alba, Ocaranza Sánchez, Raymundo, Franco Gutiérrez, Raúl, Pereira López, Eva María, López López, Andrea, Prada Delgado, Óscar, Méndez Eirín, Elizabet, Pérez Cebey, Lucía, Iglesias Río, Enrique, Rodríguez Fernández, José Ángel, Vázquez Rodríguez, José Manuel, and González-Juanatey, Carlos

Published
2024
Full Text
View/download PDF

24. MALAT1 expression is associated with aggressive behavior in indolent B-cell neoplasms

Author

Elena María Fernández-Garnacho, Ferran Nadeu, Silvia Martín, Pablo Mozas, Andrea Rivero, Julio Delgado, Eva Giné, Armando López-Guillermo, Martí Duran-Ferrer, Itziar Salaverria, Cristina López, Sílvia Beà, Santiago Demajo, Pedro Jares, Xose S. Puente, José Ignacio Martín-Subero, Elías Campo, and Lluís Hernández

Subjects
Medicine, Science
Abstract

Abstract MALAT1 long non-coding RNA has oncogenic roles but has been poorly studied in indolent B-cell neoplasms. Here, MALAT1 expression was analyzed using RNA-seq, microarrays or qRT-PCR in primary samples from clinico-biological subtypes of chronic lymphocytic leukemia (CLL, n = 266), paired Richter transformation (RT, n = 6) and follicular lymphoma (FL, n = 61). In peripheral blood (PB) CLL samples, high MALAT1 expression was associated with a significantly shorter time to treatment independently from other known prognostic factors. Coding genes expressed in association with MALAT1 in CLL were predominantly related to oncogenic pathways stimulated in the lymph node (LN) microenvironment. In RT paired samples, MALAT1 levels were lower, concordant with their acquired increased independency of external signals. Moreover, MALAT1 levels in paired PB/LN CLLs were similar, suggesting that the prognostic value of MALAT1 expression in PB is mirroring expression differences already present in LN. Similarly, high MALAT1 expression in FL predicted for a shorter progression-free survival, in association with expression pathways promoting FL pathogenesis. In summary, MALAT1 expression is related to pathophysiology and more aggressive clinical behavior of indolent B-cell neoplasms. Particularly in CLL, its levels could be a surrogate marker of the microenvironment stimulation and may contribute to refine the clinical management of these patients.

Published
2023
Full Text
View/download PDF

25. Born to be wild: Captive-born and wild Iberian lynx (Lynx pardinus) reveal space-use similarities when reintroduced for species conservation concerns

Author

Cisneros-Araujo, Pablo, Garrote, German, Corradini, Andrea, Farhadinia, Mohammad S., Robira, Benjamin, López, Guillermo, Fernández, Leonardo, López-Parra, Marcos, García-Tardío, Maribel, Arenas-Rojas, Rafael, del Rey, Teresa, Salcedo, Javier, Sarmento, Pedro, Sánchez, Juan Francisco, Palacios, María Jesús, García-Viñás, Juan Ignacio, Damiani, Maria Luisa, Hachem, Fatima, Gastón, Aitor, and Cagnacci, Francesca

Published
2024
Full Text
View/download PDF

34. Unraveling the genetics of transformed splenic marginal zone lymphoma

Author

Grau, Marta, López, Cristina, Navarro, Alba, Frigola, Gerard, Nadeu, Ferran, Clot, Guillem, Bastidas-Mora, Gabriela, Alcoceba, Miguel, Baptista, Maria Joao, Blanes, Margarita, Colomer, Dolors, Costa, Dolors, Domingo-Domènech, Eva, Enjuanes, Anna, Escoda, Lourdes, Forcada, Pilar, Giné, Eva, Lopez-Guerra, Mónica, Ramón, Olga, Rivas-Delgado, Alfredo, Vicente Folch, Laura, Wotherspoon, Andrew, Climent, Fina, Campo, Elias, López-Guillermo, Armando, Matutes, Estella, and Beà, Sílvia

Published
2023
Full Text
View/download PDF

35. SARS-CoV-2: Air pollution highly correlated to the increase in mortality. The case of Guadalajara, Jalisco, México

Author

Torres-Anguiano, Elizabeth, Sánchez-López, Itzel, Garduno-Robles, Angeles, Rivas-Carrillo, Jorge David, Rivera-León, Edgar Alfonso, Sánchez-Enríquez, Sergio, Ornelas-Hernández, Luis Fernando, Zazueta León-Quintero, Fernando, Salazar León-Quintero, Eduardo Narciso, Juárez-López, Guillermo Enrique, Sánchez-Zubieta, Fernando Antonio, Ochoa-Bru, Mariana, and Zepeda-Moreno, Abraham

Published
2023
Full Text
View/download PDF

39. Detection of early seeding of Richter transformation in chronic lymphocytic leukemia

Author

Nadeu, Ferran, Royo, Romina, Massoni-Badosa, Ramon, Playa-Albinyana, Heribert, Garcia-Torre, Beatriz, Duran-Ferrer, Martí, Dawson, Kevin J., Kulis, Marta, Diaz-Navarro, Ander, Villamor, Neus, Melero, Juan L., Chapaprieta, Vicente, Dueso-Barroso, Ana, Delgado, Julio, Moia, Riccardo, Ruiz-Gil, Sara, Marchese, Domenica, Giró, Ariadna, Verdaguer-Dot, Núria, Romo, Mónica, Clot, Guillem, Rozman, Maria, Frigola, Gerard, Rivas-Delgado, Alfredo, Baumann, Tycho, Alcoceba, Miguel, González, Marcos, Climent, Fina, Abrisqueta, Pau, Castellví, Josep, Bosch, Francesc, Aymerich, Marta, Enjuanes, Anna, Ruiz-Gaspà, Sílvia, López-Guillermo, Armando, Jares, Pedro, Beà, Sílvia, Capella-Gutierrez, Salvador, Gelpí, Josep Ll., López-Bigas, Núria, Torrents, David, Campbell, Peter J., Gut, Ivo, Rossi, Davide, Gaidano, Gianluca, Puente, Xose S., Garcia-Roves, Pablo M., Colomer, Dolors, Heyn, Holger, Maura, Francesco, Martín-Subero, José I., and Campo, Elías

Published
2022
Full Text
View/download PDF

40. Molecular Pathogenesis of Follicular Lymphoma: From Genetics to Clinical Practice

Author

Cristina López, Pablo Mozas, Armando López-Guillermo, and Sílvia Beà

Subjects
follicular lymphoma, BCL2 rearrangement, genetic alterations, histological transformation, tumor microenvironment, targeted therapies, Medicine
Abstract

Follicular lymphoma (FL), a generally indolent disease that derives from germinal center (GC) B cells, represents around 20–25% of all new lymphomas diagnosed in Western countries. The characteristic t(14;18)(q32;q21) translocation that places the BCL2 oncogene under control of the immunoglobulin heavy-chain enhancer occurs in pro- or pre-B cells. However, additional secondary alterations are required for the development of overt FL, which mainly affects genes involved in epigenetic and transcriptional regulation, signaling and B cell differentiation, the BCR/NF-κB pathway, and proliferation/apoptosis. On the other hand, new insights into the FL pathogenesis suggest that FL lacking the BCL2 translocation might be a distinct biological entity with genomic features different from the classical FL. Although FL is considered an indolent disease, around 10–20% of cases eventually transform to an aggressive lymphoma, usually a diffuse large B cell lymphoma, generally by a divergent evolution process from a common altered precursor cell acquiring genomic alterations involved in the cell cycle and DNA damage responses. Importantly, FL tumor cells require interaction with the microenvironment, which sustains cell survival and proliferation. Although the use of rituximab has improved the outlook of most FL patients, further genomic studies are needed to identify those of high risk who can benefit from innovative therapies. This review provides an updated synopsis of FL, including the molecular and cellular pathogenesis, key events of transformation, and targeted treatments.

Published
2022
Full Text
View/download PDF

41. Novel targeted drugs for follicular and marginal zone lymphoma: a comprehensive review

Author

Andrea Rivero, Pablo Mozas, Laura Magnano, and Armando López-Guillermo

Subjects
follicular lymphoma, marginal zone lymphoma, targeted therapy, immunotherapy, CAR-T cells, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Although mostly incurable, indolent non-Hodgkin lymphomas (iNHL) are chronic diseases with a median overall survival approaching 20 years. In recent years, important advances in the knowledge of the biology of these lymphomas have led to the development of new drugs, mostly chemotherapy-free, with promising outcomes. With a median age of around 70 years at diagnosis, many patients with iNHL suffer from comorbid conditions that may limit treatment options. Therefore, nowadays, in the transition towards personalized medicine, several challenges lie ahead, such as identifying predictive markers for the selection of treatment, the adequate sequencing of available therapies, and the management of new and accumulated toxicities. In this review, we include a perspective on recent therapeutic advances in follicular and marginal zone lymphoma. We describe emerging data on approved and emerging novel therapies, such as targeted therapies (PI3K inhibitors, BTK inhibitors, EZH2 inhibitors), monoclonal antibodies and antibody-drug conjugates. Finally, we describe immune-directed approaches such as combinations with lenalidomide or the even more innovative bispecific T-cell engagers and chimeric antigen receptor T-cell therapy, which can achieve a high rate of durable responses with manageable toxicities, further obviating the need for chemotherapy.

Published
2023
Full Text
View/download PDF

42. The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee

Author

Campo, Elias, Jaffe, Elaine S., Cook, James R., Quintanilla-Martinez, Leticia, Swerdlow, Steven H., Anderson, Kenneth C., Brousset, Pierre, Cerroni, Lorenzo, de Leval, Laurence, Dirnhofer, Stefan, Dogan, Ahmet, Feldman, Andrew L., Fend, Falko, Friedberg, Jonathan W., Gaulard, Philippe, Ghia, Paolo, Horwitz, Steven M., King, Rebecca L., Salles, Gilles, San-Miguel, Jesus, Seymour, John F., Treon, Steven P., Vose, Julie M., Zucca, Emanuele, Advani, Ranjana, Ansell, Stephen, Au, Wing-Yan, Barrionuevo, Carlos, Bergsagel, Leif, Chan, Wing C., Cohen, Jeffrey I., d'Amore, Francesco, Davies, Andrew, Falini, Brunangelo, Ghobrial, Irene M., Goodlad, John R., Gribben, John G., Hsi, Eric D., Kahl, Brad S., Kim, Won-Seog, Kumar, Shaji, LaCasce, Ann S., Laurent, Camille, Lenz, Georg, Leonard, John P., Link, Michael P., Lopez-Guillermo, Armando, Mateos, Maria Victoria, Macintyre, Elizabeth, Melnick, Ari M., Morschhauser, Franck, Nakamura, Shigeo, Narbaitz, Marina, Pavlovsky, Astrid, Pileri, Stefano A., Piris, Miguel, Pro, Barbara, Rajkumar, Vincent, Rosen, Steven T., Sander, Birgitta, Sehn, Laurie, Shipp, Margaret A., Smith, Sonali M., Staudt, Louis M., Thieblemont, Catherine, Tousseyn, Thomas, Wilson, Wyndham H., Yoshino, Tadashi, Zinzani, Pier-Luigi, Dreyling, Martin, Scott, David W., Winter, Jane N., and Zelenetz, Andrew D.

Published
2022
Full Text
View/download PDF

43. Dissertatio 15C revisited: Concept and Body in Kant's Problems of Directionality.

Author

Villaverde López, Guillermo

Subjects
AESTHETICS
Abstract

This article focuses on the relationship between Kant's reference to our own body in the context of problems of directionality and the type of resources that, according to him, are necessary to distinguish left and right and to orient ourselves in space. It challenges the almost universally accepted idea that the principle formulated in Dissertatio 15C (namely, that two incongruent counterparts cannot be distinguished by notae) is fatally flawed. While arguing that this principle is correct in its strongest formulation, the article offers a unified line of reasoning that runs precisely from Dissertatio 15C to the presence of the body in 1768/1786 and extends to include several important features of the Transcendental Aesthetic of the first Critique. The final part of the paper explores some of the implications of this reading for Kant's theory of space and its development. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

45. Bluetongue Virus in the Iberian Lynx (Lynx pardinus), 2010–2022.

Author

Caballero-Gómez, Javier, Sánchez-Sánchez, Marta, Lorca-Oró, Cristina, Fernández de Mera, Isabel G., Zorrilla, Irene, López, Guillermo, Rosell, Rosa, Grande-Gómez, Rebeca, Montoya-Oliver, Juan I., Salcedo, Javier, Paniagua, Jorge, Cano-Gómez, Cristina, Gonzálvez, Moisés, and García-Bocanegra, Ignacio

Subjects
BLUETONGUE virus, LYNX, VIRUS diseases, RUMINANTS, SEROTYPES
Abstract

Clinical infection and death caused by bluetongue virus infection has been reported in the Eurasian lynx. Bluetongue virus surveillance in the Iberian lynx revealed widespread and repeated exposure to serotypes 1 and 4 in wild and captive populations of this species. This exposure is possibly from a spillover event from sympatric ruminants. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

46. Genetic and phenotypic attributes of splenic marginal zone lymphoma

Author

Bonfiglio, Ferdinando, Bruscaggin, Alessio, Guidetti, Francesca, Terzi di Bergamo, Lodovico, Faderl, Martin, Spina, Valeria, Condoluci, Adalgisa, Bonomini, Luisella, Forestieri, Gabriela, Koch, Ricardo, Piffaretti, Deborah, Pini, Katia, Pirosa, Maria Cristina, Cittone, Micol Giulia, Arribas, Alberto, Lucioni, Marco, Ghilardi, Guido, Wu, Wei, Arcaini, Luca, Baptista, Maria Joao, Bastidas, Gabriela, Bea, Silvia, Boldorini, Renzo, Broccoli, Alessandro, Buehler, Marco Matteo, Canzonieri, Vincenzo, Cascione, Luciano, Ceriani, Luca, Cogliatti, Sergio, Corradini, Paolo, Derenzini, Enrico, Devizzi, Liliana, Dietrich, Sascha, Elia, Angela Rita, Facchetti, Fabio, Gaidano, Gianluca, Garcia, Juan Fernando, Gerber, Bernhard, Ghia, Paolo, Gomes da Silva, Maria, Gritti, Giuseppe, Guidetti, Anna, Hitz, Felicitas, Inghirami, Giorgio, Ladetto, Marco, Lopez-Guillermo, Armando, Lucchini, Elisa, Maiorana, Antonino, Marasca, Roberto, Matutes, Estella, Meignin, Veronique, Merli, Michele, Moccia, Alden, Mollejo, Manuela, Montalban, Carlos, Novak, Urban, Oscier, David Graham, Passamonti, Francesco, Piazza, Francesco, Pizzolitto, Stefano, Rambaldi, Alessandro, Sabattini, Elena, Salles, Gilles, Santambrogio, Elisa, Scarfò, Lydia, Stathis, Anastasios, Stüssi, Georg, Geyer, Julia T., Tapia, Gustavo, Tarella, Corrado, Thieblemont, Catherine, Tousseyn, Thomas, Tucci, Alessandra, Vanini, Giorgio, Visco, Carlo, Vitolo, Umberto, Walewska, Renata, Zaja, Francesco, Zenz, Thorsten, Zinzani, Pier Luigi, Khiabanian, Hossein, Calcinotto, Arianna, Bertoni, Francesco, Bhagat, Govind, Campo, Elias, De Leval, Laurence, Dirnhofer, Stefan, Pileri, Stefano A., Piris, Miguel A., Traverse-Glehen, Alexandra, Tzankov, Alexander, Paulli, Marco, Ponzoni, Maurilio, Mazzucchelli, Luca, Cavalli, Franco, Zucca, Emanuele, and Rossi, Davide

Published
2022
Full Text
View/download PDF

47. Post-landing major element quantification using SuperCam laser induced breakdown spectroscopy

Author

Anderson, Ryan B., Forni, Olivier, Cousin, Agnes, Wiens, Roger C., Clegg, Samuel M., Frydenvang, Jens, Gabriel, Travis S.J., Ollila, Ann, Schröder, Susanne, Beyssac, Olivier, Gibbons, Erin, Vogt, David S., Clavé, Elise, Manrique, Jose-Antonio, Legett, Carey, IV, Pilleri, Paolo, Newell, Raymond T., Sarrao, Joseph, Maurice, Sylvestre, Arana, Gorka, Benzerara, Karim, Bernardi, Pernelle, Bernard, Sylvain, Bousquet, Bruno, Brown, Adrian J., Alvarez-Llamas, César, Chide, Baptiste, Cloutis, Edward, Comellas, Jade, Connell, Stephanie, Dehouck, Erwin, Delapp, Dorothea M., Essunfeld, Ari, Fabre, Cecile, Fouchet, Thierry, Garcia-Florentino, Cristina, García-Gómez, Laura, Gasda, Patrick, Gasnault, Olivier, Hausrath, Elisabeth M., Lanza, Nina L., Laserna, Javier, Lasue, Jeremie, Lopez, Guillermo, Madariaga, Juan Manuel, Mandon, Lucia, Mangold, Nicolas, Meslin, Pierre-Yves, Nelson, Anthony E., Newsom, Horton, Reyes-Newell, Adriana L., Robinson, Scott, Rull, Fernando, Sharma, Shiv, Simon, Justin I., Sobron, Pablo, Fernandez, Imanol Torre, Udry, Arya, Venhaus, Dawn, McLennan, Scott M., Morris, Richard V., and Ehlmann, Bethany

Published
2022
Full Text
View/download PDF

49. TOP-350-YI DNA differential methylation as a potential drug-induced liver injury biomarker and genome-wide DNA methylation functional analysis

Author

De los Santos Fernández, Romina, primary, Villanueva, Marina, additional, Alvarez-Alvarez, Ismael, additional, Niu, Hao, additional, Stephens, Camilla, additional, Jiménez, Andrés González, additional, López, Guillermo Paz, additional, Bandera, Jose Pinazo, additional, Matilla, Gonzalo, additional, Lucena, Maria Isabel, additional, Medina-Caliz, Inmaculada, additional, and Andrade, Raul J., additional

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results