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1. Clinical features of post-COVID period. Results of an International Register 'Dynamics Analysis of Comorbidities in SARS-CoV-2 Survivors (ACTIV SARS-CoV-2)' (12-month follow-up)

Author

G. P. Arutyunov, E. I Tarlovskaya, A. G. Arutyunov, Yu. N. Belenkov, A. O. Konradi, Yu. M. Lopatin, A. P. Rebrov, S. N. Tereshchenko, A. I. Chesnikova, H. G. Hayrapetyan, A. P. Babin, I. G. Bakulin, N. V. Bakulina, L. A. Balykova, A. S. Blagonravova, M. V. Boldina, M. I. Butomo, A. R. Vaisberg, A. S. Galyavich, V. V. Gomonova, N. Yu. Grigorieva, I. V. Gubareva, I. V. Demko, A. V. Evzerikhina, A. V. Zharkov, A. A. Zateishchikova, U. K. Kamilova, Z. F. Kim, T. Yu. Kuznetsova, A. N. Kulikov, N. V. Lareva, E. V. Makarova, S. V. Malchikova, S. V. Nedogoda, M. M. Petrova, I. G. Pochinka, K. V. Protasov, D. N. Protsenko, D. Yu. Ruzanav, S. A. Sayganov, A. Sh. Sarybaev, N. M. Selezneva, A. B. Sugraliev, I. V. Fomin, O. V. Khlynova, O. Yu. Chizhova, I. I. Shaposhnik, D. A. Sh'ukarev, A. K. Abdrakhmanova, S. A. Avetisian, H. G. Avoyan, K. K. Azarian, G. T. Aimakhanova, D. A. Ayipova, A. Ch. Akunov, M. K. Alieva, A. R. Almukhambedova, A. V. Aparkina, O. R. Aruslanova, E. Yu. Ashina, O. Yu. Badina, O. Yu. Barysheva, T. I. Batluk, A. S. Batchayeva, R. A. Bashkinov, A. M. Bitieva, I. U. Bikhteyev, N. A. Borodulina, M. V. Bragin, V. A. Brazhnik, A. M. Budu, G. A. Bykova, K. R. Vagapova, D. D. Varlamova, N. N. Vezikova, E. A. Verbitskaya, O. E. Vilkova, E. A. Vinnikova, V. V. Vustina, E. A. Gаlova, V. V Genkel, D. B. Giller, E. I. Gorshenina, E. V. Grigorieva, E. U. Gubareva, G. M. Dabylova, A. I. Demchenko, O. Yu. Dolgikh, M. Y. Duyshobayev, D. S. Evdokimov, K. E. Egorova, A. E. Zheldybayeva, N. V. Zarechnova, Yu. D. Zimina, S. U. Ivanova, E. U. Ivanchenko, M. V. Ilina, M. V. Kazakovtseva, E. V. Kazymova, Yu. S. Kalinina, N. A. Kamardina, A. M. Karachenova, I. A. Karetnikov, N. A. Karoli, M. Kh. Karsiev, D. S. Кaskaeva, K. F. Kasymova, Zh. B. Kerimbekova, E. S. Kim, N. V. Kiseleva, D. A. Klimenko, O. V. Kovalishena, S. V. Kozlov, E. V. Kolmakova, T. P. Kolchinskaya, M. I. Koliadich, O. V. Kondriakova, M. P. Konoval, D. U. Konstantinov, E. A. Konstantinova, V. A. Kordukova, E. V. Koroleva, A. U. Kraposhina, T. V. Kryukova, A. S. Kuznetsova, T. U. Kuzmina, K. V. Kuzmichev, Ch. K. Kulchoroeva, T. V. Kuprina, I. M. Kuranova, L. V. Kurenkova, N. U. Kurchugina, N. A. Kushubakova, V. I. Levankova, A. A. Ledyaeva, T. V. Lisun, V. E. Lisyanskaya, N. A. Lyubavina, N. A. Magdeyeva, K. V. Mazalov, V. I. Maiseenko, A. S. Makarova, A. M. Maripov, N. V. Markov, A. A. Marusina, E. S. Melnikov, A. I. Metlinskaya, N. B. Moiseenko, F. N. Muradova, R. G. Muradyan, Sh. N. Musaelian, E. S. Nekaeva, N. M. Nikitina, S. E. Nifontov, E. U. Obolentseva, A. A. Obukhova, B. B. Ogurlieva, A. A. Odegova, Yu. V. Omarova, N. A. Omurzakova, Sh. O. Ospanova, V. A. Pavlova, E. V. Pahomova, L. D. Petrov, S. S. Plastinina, D. A. Platonov, V. A. Pogrebetskaya, D. V. Polyakov, D. S. Polyakov, E. V. Ponomarenko, L. L. Popova, A. A. Potanin, N. A. Prokofeva, J. D. Rabik, N. A. Rakov, A. N. Rakhimov, N. A. Rozanova, I. V. Samus, S. Serikbolkyzy, Ya. A. Sidorkina, A. A. Simonov, V. V. Skachkova, R. D. Skvortcova, D. S. Skuridin, D. V. Solovieva, I. A. Solovieva, I. M. Sukhomlinova, A. G. Sushilova, D. R. Tagayeva, E. P. Tikhonova, D. S. Tokmin, A. A. Tolmacheva, M. S. Torgunakova, K. V. Trenogina, N. A. Trostianetckaia, D. A. Trofimov, M. A. Trubnikova, A. A. Tulichev, A. T. Tursunova, N. D. Ulanova, O. V. Fatenkov, O. V. Fedorishina, T. S. Fil, I. U. Fomina, I. S. Fominova, I. A. Frolova, S. M. Tsvinger, V. V. Tsoma, M. B. Cholponbaeva, T. I. Chudinovskikh, I. V. Shavrin, O. A. Shevchenko, D. R. Shikhaliev, E. A. Shishkina, K. U. Shishkov, S. U. Sherbakov, G. V. Shcherbakova, and E. A. Yausheva

Subjects
covid-19, post-covid period, readmissions, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Aim. To investigate on post-COVID period in patients of the Eurasian region.Material and methods. A total of 9364 consecutively hospitalized patients were included in ACTIV registry. Enrollment of patients began on June 29, 2020, and was completed on March 30, 2021, corresponding to the first and second waves of the pandemic. Demographic, clinical, and laboratory data, computed tomography (CT) results, information about inhospital clinical course and complications of COVID-19 during hospitalization were extracted from electronic health records using a standardized data collection form. The design included follow-up telephone interviews with a standard questionnaire at 3, 6, and 12 months to examine the course of post-COVID period.Results. According to ACTIV register, 63% of patients after COVID-19 had new adverse symptoms or exacerbations of the existing symptoms lasting for up to 1 year. After hospital discharge, 79,8% of patients sought unscheduled medical attention in the first 3 months, 79,1% at 4-6 months, and 64,8% at 7-12 months. Readmission rate was 11,8% in the first 3 months, 10,9% at 4-6 months, and 10,1% at 7-12 months. The most common reasons for unscheduled treatment in the first 3 months were uncontrolled hypertension, decompensated type 2 diabetes, destabilization of coronary artery disease, gastrointestinal disease, AF episodes, exacerbation of asthma and chronic obstructive pulmonary disease, decompensated heart failure (HF). The 12-month mortality of COVID-19 survivors after the discharge was 3,08%. Multivariate analysis showed that independent risk factors for fatal outcome were age (direct correlation), the levels of hemoglobin (inverse correlation), oxygen saturation (inverse correlation), and aspartate aminotransferase (direct correlation), as well as class III-IV HF, prior stroke, cancer, inhospital acute kidney injury. Based on these identified risk factors, a nomogram was constructed to determine the 3-month mortality risk after discharge.Conclusion. Analysis of ACTIV register showed that end of the acute phase of COVID-19 does not imply a complete recovery.

Published
2023
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2. Lipid profile in hospitalized patients with COVID-19 depending on the outcome of its acute phase: data from the international registry 'Dynamics analysis of comorbidities in SARS-CoV-2 infection survivors'

Author

G. P. Arutyunov, E. I. Tarlovskaya, A. G. Arutyunov, Yu. N. Belenkov, A. O. Konradi, Yu. M. Lopatin, A. P. Rebrov, S. N. Tereshchenko, A. I. Chesnikova, G. G. Airapetyan, A. P. Babin, I. G. Bakulin, N. V. Bakulina, L. A. Balykova, A. S. Blagonravova, M. V. Boldina, M. I. Butomo, A. R. Vaisberg, A. S. Galyavich, V. V. Gomonova, N. Yu. Grigorieva, I. V. Gubareva, I. V. Demko, A. V. Evzerikhina, A. V. Zharkov, A. A. Zateyshchikova, U. K. Kamilova, Z. F. Kim, T. Yu. Kuznetsova, A. N. Kulikov, N. V. Lareva, E. V. Makarova, S. V. Malchikova, S. V. Nedogoda, M. M. Petrova, I. G. Pochinka, K. V. Protasov, D. N. Protsenko, D. Yu. Ruzanov, S. A. Saiganov, A. Sh. Sarybaev, N. M. Selezneva, A. B. Sugraliev, I. V. Fomin, O. V. Khlynova, O. Yu. Chizhova, I. I. Shaposhnik, D. A. Schukarev, A. K. Abdrakhmanova, S. A. Avetisyan, O. G. Avoyan, K. K. Azaryan, G. T. Aimakhanova, D. A. Aiypova, A. Ch. Akunov, M. K. Alieva, A. R. Almukhambedova, A. V. Aparkina, O. R. Aruslanova, E. Yu. Ashina, O. Yu. Badina, O. Yu. Barysheva, T. I. Batluk, A. S. Batchaeva, R. A. Bashkinov, A. M. Bitieva, I. U. Bikhteev, N. A. Borodulina, M. V. Bragin, V. A. Brazhnik, A. M. Budu, G. A. Bykova, K. R. Vagapova, D. D. Varlamova, N. N. Vezikova, E. A. Verbitskaya, O. E. Vilkova, E. A. Vinnikova, V. V. Vustina, E. A. Galova, V. V. Genkel, D. B. Giller, E. I. Gorshenina, E. V. Grigoryeva, E. Yu. Gubareva, G. M. Dabylova, A. I. Demchenko, O. Yu. Dolgikh, M. Y. Duishobaev, D. S. Evdokimov, K. E. Egorova, A. N. Ermilova, A. E. Zheldybaeva, N. V. Zarechnova, Yu. D. Zimina, S. Yu. Ivanova, E. Yu. Ivanchenko, M. V. Ilyina, M. V. Kazakovtseva, E. V. Kazymova, Yu. S. Kalinina, N. A. Kamardina, A. M. Karachenova, I. A. Karetnikov, N. A. Karoli, M. Kh. Karsiev, D. S. Kaskaeva, K. F. Kasymova, J. B. Kerimbekova, E. S. Kim, N. V. Kiseleva, D. A. Klimenko, A. V. Klimova, O. V. Kovalishena, S. V. Kozlov, E. V. Kolmakova, T. P. Kolchinskaya, M. I. Kolyadich, O. V. Kondryakova, M. P. Konoval, D. Yu. Konstantinov, E. A. Konstantinova, V. A. Kordyukova, E. V. Koroleva, A. Yu. Kraposhina, T. V. Kryukova, A. P. Kuznetsova, T. Yu. Kuzmina, K. V. Kuzmichev, Ch. K. Kulchoroeva, T. V. Kuprina, I. M. Kuranova, L. V. Kurenkova, N. Yu. Kurchugina, N. A. Kushubakova, V. I. Levankova, A. A. Ledyaeva, T. V. Lisun, V. E. Lisyanskaya, N. A. Lyubavina, N. A. Magdeeva, K. V. Mazalov, V. I. Mayseenko, A. S. Makarova, A. M. Maripov, N. V. Markov, A. A. Marusina, E. S. Melnikov, A. I. Metlinskaya, N. B. Moiseenko, F. N. Muradova, R. G. Muradyan, Sh. N. Musaelyan, E. S. Nekaeva, N. M. Nikitina, S. E. Nifontov, E. Yu. Obolentseva, A. A. Obukhova, B. B. Ogurlieva, A. A. Odegova, Yu. V. Omarova, N. A. Omurzakova, Sh. O. Ospanova, V. A. Pavlova, E. V. Pakhomova, L. D. Petrov, S. S. Plastinina, D. A. Platonov, V. A. Pogrebetskaya, D. V. Polyakov, D. S. Polyakov, E. V. Ponomarenko, L. L. Popova, A. A. Potanin, N. A. Prokofieva, Yu. D. Rabik, N. A. Rakov, A. N. Rakhimov, N. A. Rozanova, S. Serikbolkyzy, Ya. A. Sidorkina, A. A. Simonov, V. V. Skachkova, R. D. Skvortsova, D. S. Skuridin, D. V. Solovieva, I. A. Solovieva, I. M. Sukhomlinova, A. G. Sushilova, D. R. Tagaeva, Yu. V. Titoikina, E. P. Tikhonova, D. S. Tokmin, A. A. Tolmacheva, M. S. Torgunakova, K. V. Trenogina, N. A. Trostyanetskaya, D. A. Trofimov, M. A. Trubnikova, A. A. Tulichev, A. T. Tursunova, N. D. Ulanova, O. V. Fatenkov, O. V. Fedorishina, T. S. Fil, I. Yu. Fomina, I. S. Fominova, I. A. Frolova, S. M. Tsvinger, V. V. Tsoma, M. B. Cholponbaeva, T. I. Chudinovskikh, I. V. Shavrin, O. A. Shevchenko, D. R. Shikhaliev, E. A. Shishkina, K. Yu Shishkov, S. Yu. Shcherbakov, G. V. Shcherbakova, and E. A. Yausheva

Subjects
covid-19, low density lipoproteins, cholesterol, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Aim. To study the lipid profile in hospitalized patients with coronavirus disease 2019 (COVID-19) depending on the outcome of its acute phase according to the AKTIV international registry.Material and methods. The AKTIV registry included men and women over 18 years of age with a diagnosis of COVID-19, who were treated in a hospital. A total of 9364 patients were included in the registry, of which 623 patients were analyzed for levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C) and triglycerides on days 1-2 of hospitalization. The level of high-density lipoprotein cholesterol (HDL-C) was calculated using the Friedewald equation.Results. We found that a decrease in LDL-C level was significantly associated with an unfavorable prognosis for hospitalized patients with COVID-19. This pattern persisted in both univariate and multivariate analyses. LDL-C levels in the final multivariate model had a significant relationship with the prognosis (an increase in the death risk by 1,7 times with a decrease per 1 mmol/l). In addition, we found that the survival of patients with an indicator level of

Published
2022
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3. Clinical features of post-COVID-19 period. Results of the international register 'Dynamic analysis of comorbidities in SARS-CoV-2 survivors (AKTIV SARS-CoV-2)'. Data from 6-month follow-up

Author

G. P. Arutyunov, E. I. Tarlovskaya, A. G. Arutyunov, Yu. N. Belenkov, A. O. Konradi, Yu. M. Lopatin, A. P. Rebrov, S. N. Tereshchenko, A. I. Chesnikova, H. G. Hayrapetyan, A. P. Babin, I. G. Bakulin, N. V. Bakulina, L. A. Balykova, A. S. Blagonravova, M. V. Boldina, A. R. Vaisberg, A. S. Galyavich, V. V. Gomonova, N. Yu. Grigorieva, I. V. Gubareva, I. V. Demko, A. V. Evzerikhina, A. V. Zharkov, U. K. Kamilova, Z. F. Kim, T. Yu. Kuznetsova, N. V. Lareva, E. V. Makarova, S. V. Malchikova, S. V. Nedogoda, M. M. Petrova, I. G. Pochinka, K. V. Protasov, D. N. Protsenko, D. Yu. Ruzanau, S. A. Sayganov, A. Sh. Sarybaev, N. M. Selezneva, A. B. Sugraliev, I. V. Fomin, O. V. Khlynova, O. Yu. Chizhova, I. I. Shaposhnik, D. A. Shchukarev, A. K. Abdrahmanova, S. A. Avetisian, H. G. Avoyan, K. K. Azarian, G. T. Aimakhanova, D. A. Ayipova, A. Ch. Akunov, M. K. Alieva, A. V. Aparkina, O. R. Aruslanova, E. Yu. Ashina, O. Yu. Badina, O. Yu. Barisheva, T. I. Batluk, A. S. Batchayeva, R. A. Bashkinov, A. M. Bitieva, I. U. Bikhteyev, N. A. Borodulina, M. V. Bragin, A. M. Budu, G. A. Bykova, K. R. Vagapova, D. D. Varlamova, N. N. Vezikova, E. A. Verbitskaya, O. E. Vilkova, E. A. Vinnikova, V. V. Vustina, E. A. Gаlova, V. V. Genkel, E. I. Gorshenina, E. V. Grigorieva, E. Yu. Gubareva, G. M. Dabylova, I. A. Demchenko, O. Yu. Dolgikh, M. Y. Duyshobayev, D. S. Evdokimov, K. E. Egorova, A. N. Ermilova, A. E. Zheldybayeva, N. V. Zarechnova, Yu. D. Zimina, S. Yu. Ivanova, E. Yu. Ivanchenko, M. V. Ilina, M. V. Kazakovtseva, E. V. Kazymova, Yu. S. Kalinina, N. A. Kamardina, A. M. Karachenova, I. A. Karetnikov, N. A. Karoli, M. K. Karsiev, D. S. Кaskaeva, K. F. Kasymova, Zh. B. Kerimbekova, A. Sh. Kerimova, E. S. Kim, N. V. Kiseleva, D. A. Klimenko, A. V. Klimova, O. V. Kovalishena, E. V. Kolmakova, T. P. Kolchinskaya, M. I. Kolyadich, O. V. Kondriakova, M. P. Konoval, D. Yu. Konstantinov, E. A. Konstantinova, V. A. Kordukova, E. V. Koroleva, A. Yu. Kraposhina, T. V. Kriukova, A. S. Kuznetsova, T. Yu. Kuzmina, K. V. Kuzmichev, Ch. K. Kulchoroeva, T. V. Kuprina, I. M. Kouranova, L. V. Kurenkova, N. Yu. Kurchugina, N. A. Kushubakova, V. I. Levankova, N. A. Lyubavina, N. A. Magdeyeva, K. V. Mazalov, V. I. Majseenko, A. S. Makarova, A. M. Maripov, A. A. Marusina, E. S. Melnikov, N. B. Moiseenko, F. N. Muradova, R. G. Muradyan, Sh. N. Musaelian, A. O. Myshak, E. S. Nekaeva, N. M. Nikitina, B. B. Ogurlieva, A. A. Odegova, Yu. M. Omarova, N. A. Omurzakova, Sh. O. Ospanova, E. V. Pahomova, L. D. Petrov, S. S. Plastinina, V. A. Pogrebetskaya, D. V. Polyakov, D. S. Polyakov, E. V. Ponomarenko, L. L. Popova, N. A. Prokofeva, I. A. Pudova, N. A. Rakov, A. N. Rakhimov, N. A. Rozanova, S. Serikbolkyzy, A. A. Simonov, V. V. Skachkova, D. V. Soloveva, I. A. Soloveva, I. M. Sukhomlinova, A. G. Sushilova, D. R. Tagayeva, Yu. V. Titojkina, E. P. Tikhonova, D. S. Tokmin, A. A. Tolmacheva, M. S. Torgunakova, K. V. Trenogina, N. A. Trostianetckaia, D. A. Trofimov, M. A. Trubnikova, A. A. Tulichev, A. T. Tursunova, N. D. Ulanova, O. V. Fatenkov, O. V. Fedorishina, T. S. Fil, I. Yu. Fomina, I. S. Fominova, I. A. Frolova, S. M. Tsvinger, V. V. Tsoma, M. B. Cholponbaeva, T. I. Chudinovskikh, O. A. Shevchenko, T. V. Sheshina, E. A. Shishkina, K. Yu. Shishkov, S. Yu. Sherbakov, and E. A. Yausheva

Subjects
covid-19, aktiv register, cardiovascular diseases, diabetes, postcovid-19 period, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Aim. To study the clinical course specifics of coronavirus disease 2019 (COVID-19) and comorbid conditions in COVID-19 survivors 3, 6, 12 months after recovery in the Eurasian region according to the AKTIV register. Material and methods.The AKTIV register was created at the initiative of the Eurasian Association of Therapists. The AKTIV register is divided into 2 parts: AKTIV 1 and AKTIV 2. The AKTIV 1 register currently includes 6300 patients, while in AKTIV 2 — 2770. Patients diagnosed with COVID-19 receiving in- and outpatient treatment have been anonymously included on the registry. The following 7 countries participated in the register: Russian Federation, Republic of Armenia, Republic of Belarus, Republic of Kazakhstan, Kyrgyz Republic, Republic of Moldova, Republic of Uzbekistan. This closed multicenter register with two nonoverlapping branches (in- and outpatient branch) provides 6 visits: 3 in-person visits during the acute period and 3 telephone calls after 3, 6, 12 months. Subject recruitment lasted from June 29, 2020 to October 29, 2020. Register will end on October 29, 2022. A total of 9 fragmentary analyzes of the registry data are planned. This fragment of the study presents the results of the post-hospitalization period in COVID-19 survivors after 3 and 6 months. Results. According to the AKTIV register, patients after COVID-19 are characterized by long-term persistent symptoms and frequent seeking for unscheduled medical care, including rehospitalizations. The most common causes of unplanned medical care are uncontrolled hypertension (HTN) and chronic coronary artery disease (CAD) and/or decompensated type 2 diabetes (T2D). During 3- and 6-month follow-up after hospitalization, 5,6% and 6,4% of patients were diagnosed with other diseases, which were more often presented by HTN, T2D, and CAD. The mortality rate of patients in the post-hospitalization period was 1,9% in the first 3 months and 0,2% for 4-6 months. The highest mortality rate was observed in the first 3 months in the group of patients with class II-IV heart failure, as well as in patients with cardiovascular diseases and cancer. In the pattern of death causes in the post-hospitalization period, following cardiovascular causes prevailed (31,8%): acute coronary syndrome, stroke, acute heart failure. Conclusion. According to the AKTIV register, the health status of patients after COVID-19 in a serious challenge for healthcare system, which requires planning adequate health system capacity to provide care to patients with COVID-19 in both acute and post-hospitalization period.

Published
2021
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4. International register 'Dynamics analysis of comorbidities in SARS-CoV-2 survivors' (AKTIV SARS-CoV-2): analysis of predictors of short-term adverse outcomes in COVID-19

Author

G. P. Arutyunov, E. I. Tarlovskaya, A. G. Arutyunov, Y. N. Belenkov, A. O. Konradi, Y. M. Lopatin, A. P. Rebrov, S. N. Tereshchenko, A. I. Chesnikova, H. G. Hayrapetyan, A. P. Babin, I. G. Bakulin, N. V. Bakulina, L. A. Balykova, A. S. Blagonravova, M. V. Boldina, A. R. Vaisberg, A. S. Galyavich, V. V. Gomonova, N. U. Grigorieva, I. V. Gubareva, I. V. Demko, A. V. Evzerikhina, A. V. Zharkov, U. K. Kamilova, Z. F. Kim, T. Yu. Kuznetsova, N. V. Lareva, E. V. Makarova, S. V. Malchikova, S. V. Nedogoda, M. M. Petrova, I. G. Pochinka, K. V. Protasov, D. N. Protsenko, D. Yu. Ruzanov, S. A. Sayganov, A. Sh. Sarybaev, N. M. Selezneva, A. B. Sugraliev, I. V. Fomin, O. V. Khlynova, O. Yu. Chizhova, I. I. Shaposhnik, D. A. Schukarev, A. K. Abdrahmanova, S. A. Avetisian, H. G. Avoyan, K. K. Azarian, G. T. Aimakhanova, D. A. Ayipova, A. Ch. Akunov, M. K. Alieva, A. V. Aparkina, O. R. Aruslanova, E. Yu. Ashina, O. Y. Badina, O. Yu. Barisheva, A. S. Batchayeva, I. U. Bikhteyev, N. A. Borodulina, M. V. Bragin, A. M. Budu, L. A. Burygina, G. A. Bykova, D. D. Varlamova, N. N. Vezikova, E. A. Verbitskaya, O. E. Vilkova, E. A. Vinnikova, V. V. Vustina, E. A. Gаlova, V. V. Genkel, E. I. Gorshenina, R. V. Gostishev, E. V. Grigorieva, E. Yu. Gubareva, G. M. Dabylova, A. I. Demchenko, O. Yu. Dolgikh, I. A. Duvanov, M. Y. Duyshobayev, D. S. Evdokimov, K. E. Egorova, A. N. Ermilova, A. E. Zheldybayeva, N. V. Zarechnova, S. Yu. Ivanova, E. Yu. Ivanchenko, M. V. Ilina, M. V. Kazakovtseva, E. V. Kazymova, Yu. S. Kalinina, N. A. Kamardina, A. M. Karachenova, I. A. Karetnikov, N. A. Karoli, O. V. Karpov, M. Kh. Karsiev, D. S. Kaskaeva, K. F. Kasymova, Zh. B. Kerimbekova, A. Sh. Kerimova, E. S. Kim, N. V. Kiseleva, D. A. Klimenko, A. V. Klimova, O. V. Kovalishena, E. V. Kolmakova, T. P. Kolchinskaya, M. I. Kolyadich, O. V. Kondriakova, M. P. Konoval, D. Yu. Konstantinov, E. A. Konstantinova, V. A. Kordukova, E. V. Koroleva, A. Yu. Kraposhina, T. V. Kriukova, A. S. Kuznetsova, T. Y. Kuzmina, K. V. Kuzmichev, Ch. K. Kulchoroeva, T. V. Kuprina, I. V. Kouranova, L. V. Kurenkova, N. Yu. Kurchugina, N. A. Kushubakova, V. I. Levankova, M. E. Levin, N. A. Lyubavina, N. A. Magdeyeva, K. V. Mazalov, V. I. Majseenko, A. S. Makarova, A. M. Maripov, A. A. Marusina, E. S. Melnikov, N. B. Moiseenko, F. N. Muradova, R. G. Muradyan, Sh. N. Musaelian, N. M. Nikitina, B. B. Ogurlieva, A. A. Odegova, Yu. M. Omarova, N. A. Omurzakova, Sh. O. Ospanova, E. V. Pahomova, L. D. Petrov, S. S. Plastinina, V. A. Pogrebetskaya, D. S. Polyakov, E. V. Ponomarenko, L. L. Popova, N. A. Prokofeva, I. A. Pudova, N. A. Rakov, A. N. Rakhimov, N. A. Rozanova, S. Serikbolkyzy, A. A. Simonov, V. V. Skachkova, L. A. Smirnova, D. V. Soloveva, I. A. Soloveva, F. M. Sokhova, A. K. Subbotin, I. M. Sukhomlinova, A. G. Sushilova, D. R. Tagayeva, Yu. V. Titojkina, E. P. Tikhonova, D. S. Tokmin, M. S. Torgunakova, K. V. Trenogina, N. A. Trostianetckaia, D. A. Trofimov, A. A. Tulichev, D. I. Tupitsin, A. T. Tursunova, N. D. Ulanova, O. V. Fatenkov, O. V. Fedorishina, T. S. Fil, I. Yu. Fomina, I. S. Fominova, I. A. Frolova, S. M. Tsvinger, V. V. Tsoma, M. B. Cholponbaeva, T. I. Chudinovskikh, L. D. Shakhgildyan, O. A. Shevchenko, T. V. Sheshina, E. A. Shishkina, K. Yu. Shishkov, S. Y. Sherbakov, and E. A. Yausheva

Subjects
aktiv register, covid-19, multimorbidity, mortality predictors, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

The international AKTIV register presents a detailed description of out- and inpatients with COVID-19 in the Eurasian region. It was found that hospitalized patients had more comorbidities. In addition, these patients were older and there were more men than among outpatients. Among the traditional risk factors, obesity and hypertension had a significant negative effect on prognosis, which was more significant for patients 60 years of age and older. Among comorbidities, CVDs had the maximum negative effect on prognosis, and this effect was more significant for patients 60 years of age and older. Among other comorbidities, type 2 and 1 diabetes, chronic kidney disease, chronic obstructive pulmonary disease, cancer and anemia had a negative impact on the prognosis. This effect was also more significant (with the exception of type 1 diabetes) for patients 60 years and older. The death risk in patients with COVID-19 depended on the severity and type of multimorbidity. Clusters of diseases typical for deceased patients were identified and their impact on prognosis was determined. The most unfavorable was a cluster of 4 diseases, including hypertension, coronary artery disease, heart failure, and diabetes mellitus. The data obtained should be taken into account when planning measures for prevention (vaccination priority groups), treatment and rehabilitation of COVID-19 survivors.

Published
2021
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5. International register 'Dynamics analysis of comorbidities in SARS-CoV-2 survivors' (AKTIV) and the register 'Analysis of hospitalizations of comorbid patients infected during the second wave of SARS-CoV-2 outbreak' (AKTIV 2)

Author

G. P. Arutyunov, E. I. Tarlovskaya, A. G. Arutyunov, Y. N. Belenkov, A. O. Konradi, Y. M. Lopatin, A. P. Rebrov, S. N. Tereshchenko, A. I. Chesnikova, H. G. Hayrapetyan, A. P. Babin, I. G. Bakulin, N. V. Bakulina, l. A. Balykova, A. S. Blagonravova, M. V. Boldina, A. R. Vaisberg, A. S. Galyavich, V. V. Gomonova, N. U. Grigorieva, I. V. Gubareva, I. V. Demko, A. V. Evzerikhina, A. V. Zharkov, U. K. Kamilova, Z. F. Kim, T. Yu. Kuznetsova, N. V. Lareva, E. V. Makarova, S. V. Malchikova, S. V. Nedogoda, M. M. Petrova, I. G. Pochinka, K. V. Protasov, D. N. Protsenko, D. Yu. Ruzanov, S. A. Sayganov, A. Sh. Sarybaev, N. M. Selezneva, A. B. Sugraliev, I. V. Fomin, O. V. Khlynova, O. Yu. Chizhova, I. I. Shaposhnik, D. A. Sсhukarev, A. K. Abdrahmanova, S. A. Avetisian, H. G. Avoyan, K. K. Azarian, G. T. Aimakhanova, D. A. Ayipova, A. Ch. Akunov, M. K. Alieva, A. V. Aparkina, O. R. Aruslanova, E. Yu. Ashina, O. Y. Badina, O. Yu. Barisheva, A. S. Batchayeva, A. M. Bitieva, I. U. Bikhteyev, N. A. Borodulina, M. V. Bragin, A. M. Budu, L. A. Burygina, G. A. Bykova, D. D. Varlamova, N. N. Vezikova, E. A. Verbitskaya, O. E. Vilkova, E. A. Vinnikova, V. V. Vustina, E. A. Gаlova, V. V. Genkel, E. I. Gorshenina, E. V. Grigorieva, E. Yu. Gubareva, G. M. Dabylova, A. I. Demchenko, O. Yu. Dolgikh, I. A. Duvanov, M. Y. Duyshobayev, D. S. Evdokimov, K. E. Egorova, A. N. Ermilova, A. E. Zheldybayeva, N. V. Zarechnova, S. Yu. Ivanova, E. Yu. Ivanchenko, M. V. Ilina, M. V. Kazakovtseva, E. V. Kazymova, Yu. S. Kalinina, N. A. Kamardina, A. M. Karachenova, I. A. Karetnikov, N. A. Karoli, O. V. Karpov, M. Kh. Karsiev, D. S. Кaskaeva, K. F. Kasymova, Zh. B. Kerimbekova, A. Sh. Kerimova, E. S. Kim, N. V. Kiseleva, D. A. Klimenko, A. V. Klimova, O. V. Kovalishena, E. V. Kolmakova, T. P. Kolchinskaya, M. I. Kolyadich, O. V. Kondriakova, M. P. Konoval, D. Yu. Konstantinov, E. A. Konstantinova, V. A. Kordukova, E. V. Koroleva, A. Yu. Kraposhina, T. V. Kriukova, A. S. Kuznetsova, T. Y. Kuzmina, K. V. Kuzmichev, Ch. K. Kulchoroeva, T. V. Kuprina, I. M. Kouranova, L. V. Kurenkova, N. Yu. Kurchugina, N. A. Kushubakova, V. I. Levankova, M. E. Levin, N. A. Lyubavina, N. A. Magdeyeva, K. V. Mazalov, V. I. Majseenko, A. S. Makarova, A. M. Maripov, A. A. Marusina, E. S. Melnikov, N. B. Moiseenko, F. N. Muradova, R. G. Muradyan, Sh. N. Musaelian, N. M. Nikitina, B. B. Ogurlieva, A. A. Odegova, Yu. M. Omarova, N. A. Omurzakova, Sh. O. Ospanova, E. V. Pahomova, L. D. Petrov, S. S. Plastinina, V. A. Pogrebetskaya, D. S. Polyakov, E. V. Ponomarenko, L. L. Popova, N. A. Prokofeva, I. A. Pudova, N. A. Rakov, A. N. Rakhimov, N. A. Rozanova, S. Serikbolkyzy, A. A. Simonov, V. V. Skachkova, L. A. Smirnova, D. V. Soloveva, I. A. Soloveva, F. M. Sokhova, A. K. Subbotin, I. M. Sukhomlinova, A. G. Sushilova, D. R. Tagayeva, Yu. V. Titojkina, E. P. Tikhonova, D. S. Tokmin, M. S. Torgunakova, K. V. Trenogina, N. A. Trostianetckaia, D. A. Trofimov, A. A. Tulichev, D. I. Tupitsin, A. T. Tursunova, A. A. Tiurin, N. D. Ulanova, O. V. Fatenkov, O. V. Fedorishina, T. S. Fil, I. Yu. Fomina, I. S. Fominova, I. A. Frolova, S. M. Tsvinger, V. V. Tsoma, M. B. Cholponbaeva, T. I. Chudinovskikh, L. D. Shakhgildyan, O. A. Shevchenko, T. V. Sheshina, E. A. Shishkina, K. Yu. Shishkov, S. Y. Sherbakov, and E. A. Yausheva

Subjects
sars-cov-2, registry, covid-19, comorbidity, risk, multimorbidity, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

The organizer of the registers “Dynamics analysis of comorbidities in SARSCoV-2 survivors” (AKTIV) and “Analysis of hospitalizations of comorbid patients infected during the second wave of SARS-CoV-2 outbreak” (AKTIV 2) is the Eurasian Association of Therapists (EAT). Currently, there are no clinical registries in the Eurasian region designed to collect and analyze information on long-term outcomes of COVID-19 survivors with comorbid conditions. The aim of the register is to assess the impact of a novel coronavirus infection on long-term course of chronic non-communicable diseases 3, 6, 12 months after recovery, as well as to obtain information on the effect of comorbidity on the severity of COVID-19. Analysis of hospitalized patients of a possible second wave is planned for register “AKTIV 2”. To achieve this goal, the register will include men and women over 18 years of age diagnosed with COVID-19 who are treated in a hospital or in outpatient basis. The register includes 25 centers in 5 federal districts of the Russian Federation, centers in the Republic of Armenia, the Republic of Kazakhstan, the Republic of Kyrgyzstan, the Republic of Belarus, the Republic of Moldova, and the Republic of Uzbekistan. The estimated capacity of the register is 5400 patients.

Published
2021
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6. The impact of BMI on the course of the acute SARS-COV-2 infection and the risks that emerge during the first year after the hospital discharge. Subanalysis evidence of the AKTIV and AKTIV 2 registries

Author

A. G. Arutyunov, E. I. Tarlovskaya, G. R. Galstyan, T. I. Batluk, R. A. Bashkinov, G. P. Arutyunov, Yu. N. Belenkov, A. O. Konradi, Yu. M. Lopatin, A. P. Rebrov, S. N. Tereshchenko, A. I. Chesnikova, H. G. Hayrapetyan, A. P. Babin, I. G. Bakulin, N. V. Bakulina, L. A. Balykova, A. S. Blagonravova, M. V. Boldina, M. I. Butomo, A. R. Vaisberg, A. S. Galyavich, V. V. Gomonova, N. Yu. Grigoryeva, I. V. Gubareva, I. V. Demko, A. V. Evzerikhina, A. V. Zharkov, A. A. Zateishchikova, U. K. Kamilova, Z. F. Kim, T. Yu. Kuznetsova, A. N. Kulikov, N. V. Lareva, E. V. Makarova, S. V. Malchikova, S. V. Nedogoda, M. M. Petrova, I. G. Pochinka, K. V. Protasov, D. N. Protsenko, D. Yu. Ruzanov, S. A. Saiganov, A. Sh. Sarybaev, N. M. Selezneva, A. B. Sugraliev, I. V. Fomin, O. V. Khlynova, O. Yu. Chizhova, I. I. Shaposhnik, D. A. Schukarev, A. K. Abdrakhmanova, S. A. Avetisyan, H. G. Avoyan, K. K. Azaryan, G. T. Aimakhanova, D. A. Ayypova, A. Ch. Akunov, M. K. Alieva, A. R. Almukhambedova, A. V. Aparkina, O. R. Aruslanova, E. Yu. Ashina, O. Yu. Badina, O. Yu. Barysheva, A. S. Batchaeva, A. M. Bitieva, I. U. Bikhteev, N. A. Borodulina, M. V. Bragin, V. A. Brazhnik, A. M. Budu, G. A. Bykova, K. R. Vagapova, D. D. Varlamova, N. N. Vezikova, E. A. Verbitskaya, O. E. Vilkova, E. A. Vinnikova, V. V. Vustina, E. A. Galova, V. V. Genkel, D. B. Giller, E. I. Gorshenina, E. V. Grigoryeva, E. Yu. Gubareva, G. M. Dabylova, A. I. Demchenko, O. Yu. Dolgikh, M. Y. Duishobaev, D. S. Evdokimov, K. E. Egorova, A. N. Ermilova, A. E. Zheldybaeva, N. V. Zarechnova, Yu. D. Zimina, S. Yu. Ivanova, E. Yu. Ivanchenko, M. V. Ilina, M. V. Kazakovtseva, E. V. Kazymova, Yu. S. Kalinina, N. A. Kamardina, A. M. Karachenova, I. A. Karetnikov, N. A. Karoli, M. Kh. Karsiev, D. S. Kaskaeva, K. F. Kasymova, Zh. B. Kerimbekova, E. S. Kim, N. V. Kiseleva, D. A. Klimenko, A. V. Klimova, O. V. Kovalishena, S. V. Kozlov, E. V. Kolmakova, T. P. Kolchinskaya, M. I. Kolyadich, O. V. Kondryakova, M. P. Konoval, D. Yu. Konstantinov, E. A. Konstantinova, V. A. Kordyukova, E. V. Koroleva, A. Yu. Kraposhina, T. V. Kryukova, A. S. Kuznetsova, T. Yu. Kuzmina, K. V. Kuzmichev, Ch. K. Kulchoroeva, T. V. Kuprina, I. M. Kuranova, L. V. Kurenkova, N. Yu. Kurchugina, N. A. Kushubakova, V. I. Levankova, A. A. Ledyaeva, T. V. Lisun, V. E. Lisyanskaya, N. A. Lyubavina, N. A. Magdeeva, K. V. Mazalov, V. I. Mayseenko, A. S. Makarova, A. M. Maripov, N. V. Markov, A. A. Marusina, E. S. Melnikov, A. I. Metlinskaya, N. B. Moiseenko, F. N. Muradova, R. G. Muradyan, Sh. N. Musaelyan, E. S. Nekaeva, N. M. Nikitina, S. E. Nifontov, E. Yu. Obolentseva, A. A. Obukhova, B. B. Ogurlieva, A. A. Odegova, Yu. V. Omarova, N. A. Omurzakova, Sh. O. Ospanova, V. A. Pavlova, E. V. Pakhomova, L. D. Petrov, S. S. Plastinina, D. A. Platonov, V. A. Pogrebetskaya, D. V. Polyakov, D. S. Polyakov, E. V. Ponomarenko, L. L. Popova, A. A. Potanin, N. A. Prokofieva, Yu. D. Rabik, N. A. Rakov, A. N. Rakhimov, N. A. Rozanova, I. V. Samus, S. Serikbolkyzy, Ya. A. Sidorkina, A. A. Simonov, V. V. Skachkova, R. D. Skvortsova, D. S. Skuridin, D. V. Solovieva, I. A. Solovieva, I. M. Sukhomlinova, A. G. Sushilova, D. R. Tagaeva, Yu. V. Titoykina, E. P. Tikhonova, D. S. Tokmin, A. A. Tolmacheva, M. S. Torgunakova, K. V. Trenogina, N. A. Trostyanetskaya, D. A. Trofimov, M. A. Trubnikova, A. A. Tulichev, A. T. Tursunova, N. D. Ulanova, O. V. Fatenkov, O. V. Fedorishina, T. S. Fil, I. Yu. Fomina, I. S. Fominova, I. A. Frolova, S. M. Tsvinger, V. V. Tsoma, M. B. Cholponbaeva, T. I. Chudinovskikh, I. V. Shavrin, O. A. Shevchenko, D. R. Shikhaliev, E. A. Shishkina, K. Yu. Shishkov, S. Yu. Shcherbakov, G. V. Shcherbakova, and E. A. Yausheva

Subjects
Endocrinology, Diabetes and Metabolism
Abstract

BACKGROUND. There is enough evidence of the negative impact of excess weight on the formation and progression of res piratory pathology. Given the continuing SARS-CoV-2 pandemic, it is relevant to determine the relationship between body mass index (BMI) and the clinical features of the novel coronavirus infection (NCI).AIM. To study the effect of BMI on the course of the acute SARS-COV-2 infection and the post-covid period.MATERIALS AND METHODS. AKTIV and AKTIV 2 are multicenter non-interventional real-world registers. The АКТИВ registry (n=6396) includes non-overlapping outpatient and inpatient arms with 6 visits in each. The АКТИВ 2 registry (n=2968) collected the data of hospitalized patients and included 3 visits. All subjects were divided into 3 groups: not overweight (n=2139), overweight (n=2931) and obese (n=2666).RESULTS. A higher BMI was significantly associated with a more severe course of the infection in the form of acute kidney injury (p=0.018), cytokine storm (pCONCLUSION. Overweight and/or obesity is a significant risk factor for severe course of the new coronavirus infection and the associated cardiovascular and kidney damage Overweight people and patients with the 1st and 2nd degree obesity tend to have a high risk of death of SARS-CoV-2 infection in both acute and post-covid periods. On top of that, in case of morbid obesity patients this tendency is statistically significant. Normalization of body weight is a strategic objective of modern medicine and can contribute to prevention of respiratory conditions, severe course and complications of the new coronavirus infection.

Published
2023

7. Newly diagnosed diseases and the frequency of their occurrence in patients after a new coronavirus infection. Results of an International Register 'Dynamics Analysis of Comorbidities in SARS-CoV-2 Survivors (ACTIV SARS-CoV-2)' (12-month follow-up)

Author

G. P. Arutyunov, E. I. Tarlovskaya, A. G. Arutyunov, D. S. Polyakov, Yu. N. Belenkov, A. O. Konradi, Yu. M. Lopatin, A. P. Rebrov, S. N. Tereshchenko, A. I. Chesnikova, H. G. Hayrapetyan, A. P. Babin, I. G. Bakulin, N. V. Bakulina, L. A. Balykova, A. S. Blagonravova, M. V. Boldina, M. I. Butomo, A. R. Vaisberg, A. S. Galyavich, V. V. Gomonova, N. Yu. Grigoryeva, I. V. Gubareva, I. V. Demko, A. V. Evzerikhina, A. V. Zharkov, A. A. Zateishchikova, U. K. Kamilova, Z. F. Kim, T. Yu. Kuznetsova, A. N. Kulikov, N. V. Lareva, E. V. Makarova, S. V. Malchikova, S. V. Nedogoda, M. M. Petrova, I. G. Pochinka, K. V. Protasov, D. N. Protsenko, D. Yu. Ruzanov, S. A. Saiganov, A. Sh. Sarybaev, N. M. Selezneva, A. B. Sugraliev, I. V. Fomin, O. V. Khlynova, O. Yu. Chizhova, I. I. Shaposhnik, D. A. Schukarev, A. K. Abdrakhmanova, S. A. Avetisyan, H. G. Avoyan, K. K. Azaryan, G. T. Aimakhanova, D. A. Ayypova, A. Ch. Akunov, M. K. Alieva, A. R. Almukhambedova, O. Yu. Aparkina, O. R. Aruslanova, E. Yu. Ashina, O. Yu. Badina, O. Yu. Barysheva, T. I. Batluk, A. S. Batchaeva, R. A. Bashkinov, A. M. Bitieva, I. U. Bikhteev, N. A. Borodulina, M. V. Bragin, V. A. Brazhnik, A. M. Budu, G. A. Bykova, K. R. Vagapova, D. D. Varlamova, N. N. Vezikova, E. A. Verbitskaya, O. E. Vilkova, E. .A. Vinnikova, V. V. Vustina, E. A. Elena A. Galova, V. V. Genkel, D. B. Giller, E. D. Gordeychuk, E. I. Gorshenina, E. V. Grigoryeva, E. Yu. Gubareva, G. M. Dabylova, A. I. Demchenko, O. Yu. Dolgikh, M. Y. Duishobaev, D. S. Evdokimov, K. E. Egorova48, A. E. Zheldybaeva, N. V. Zarechnova, Yu. D. Zimina, S. Yu. Ivanova, E. Yu. Ivanchenko, M. V. Ilina, M. V. Kazakovtseva, E. V. Kazymova, Yu. S. Yuliya S. Kalinina, N. A. Kamardina, A. M. Karachenova, I. A. Karetnikov, N. A. Karoli, M. Kh. Karsiev, D. S. Kaskaeva, K. F. Kasymova, Zh. B. Kerimbekova, E. S. Kim, N. V. Kiseleva, D. A. Klimenko, O. V. Kovalishena, S. V. Kozlov, E. V. Kolmakova, T. P. Kolchinskaya, M. I. Kolyadich, O. V. Kondryakova, M. P. Konoval, D. Yu. Konstantinov, E. A. Konstantinova, V. A. Kordyukova, E. V. Koroleva, A. Yu. Kraposhina, T. V. Kryukova, A. S. Kuznetsova, T. Yu. Kuzmina, K. V. Kuzmichev, C. K. Kulchoroeva, T. V. Kuprina, I. M. Kuranova, L. V. Kurenkova, N. Yu. Kurchugina, N. A. Kushubakova, V. I. Levankova, A. A. Ledyaeva, T. V. Lisun, V. E. Lisyanskaya, N. A. Lyubavina, N. A. Magdeeva, K. V. Mazalov, V. I. Mayseenko, A. S. Makarova, A. M. Maripov, N. V. Markov, A. A. Marusina, E. S. Melnikov, A. I. Metlinskaya, N. B. Moiseenko, F. N. Muradova, R. G. Muradyan, Sh. N. Musaelyan, E. S. Nekaeva, N. M. Nikitina, S. E. Nifontov, E. Yu. Obolentseva, A. A. Obukhova, B. B. Ogurlieva, A. A. Odegova, Yu. V. Yuliya V. Omarova, N. A. Omurzakova, Sh. O. Ospanova, V. A/ Pavlova, E. V. Pakhomova, L. D. Petrov, S. S. Plastinina, D. A. Platonov, V. A. Pogrebetskaya, D. V. Polyakov, E. V. Ponomarenko, L. L. Popova, A. A. Potanin, N. A. Prokofieva, Yu. D. Rabik, N. A. Rakov, A. N. Rakhimov, N. A. Rozanova, S. Serikbolkyzy, Ya. A. Sidorkina, A. A. Simonov, V. V. Skachkova, R. D. Skvortsova, D. S. Skuridin, D. V. Solovieva, I. A. Solovieva, I. M. Sukhomlinova, A. G. Sushilova, D. R. Tagaeva, E. P. Tikhonova, D. S. Tokmin, A. A. Tolmacheva, M. S. Torgunakova, K. V. Trenogina, N. A. Trostyanetskaya, D. A. Trofimov, M. A. Trubnikova, A. A. Tulichev, A. T. Tursunova, N. D. Ulanova, O. V. Fatenkov, O. V. Fedorishina, T. S. Fil, I. Yu. Fomina, I. S. Fominova, I. A. Frolova, S. M. Tsvinger, V. V. Tsoma, M. B. Cholponbaeva, T. I. Chudinovskikh, I. V. Shavrin, O. A. Shevchenko, D. R. Shikhaliev, E. A. Shishkina, K. Yu. Shishkov, S. Yu Shcherbakov, G. V. Shcherbakova, and E. A. Yausheva

Subjects
Cardiology and Cardiovascular Medicine
Abstract

Aim. To analyze newly diagnosed diseases and features of the post-COVID course in patients after a coronavirus disease 2019 (COVID-19) within 12-month follow-up.Material and methods. A total of 9364 consecutively hospitalized patients were included in the ACTIV registry. Enrollment of patients began on June 29, 2020, and was completed on March 30, 2021, corresponding to the first and second waves of the pandemic. Demographic, clinical, and laboratory data, computed tomography (CT) results, information about inhospital clinical course and complications of COVID-19 during hospitalization were extracted from electronic health records using a standardized data collection form. The design included follow-up telephone interviews with a standard questionnaire at 3, 6, and 12 months to examine the course of post-COVID period.Results. According to the ACTIV registry, 18,1% of patients after COVID-19 had newly diagnosed diseases (NDDs) over the next 12 months. Hypertension (HTN), type 2 diabetes and coronary artery disease (CAD) prevailed in the NDD structure. Comparison of the age-standardized incidence of NDDs (HTN, CAD, diabetes) in the post-COVID period in the ACTIV registry with NDD incidence in 2019 according to Rosstat and the expected incidence of NDDs according to the EPOHA study revealed that HTN, diabetes, CAD in patients after COVID-19 were registered more often as follows: HTN by 7,0 and 4,4 times, diabetes by 7,3 and 8,8 times, CAD by 2,3 and 2,9 times, respectively. NDDs most often developed in patients aged 47 to 70 years. Comparison of the actual and expected number of cases of newly diagnosed HTN, CAD and diabetes depending on age showed that the actual number of cases in the population of patients in the ACTIV register is significantly higher than expected for patients aged 45-69 years and for patients with hypertension or diabetes and aged Conclusion. Available evidence suggests that a strategy for managing COVID-19 survivors should include mandatory screening for early detection of cardiovascular disease and diabetes, which will be key to reducing the risk of further COVID-19 consequences.

Published
2023

8. [ACTIV SARS-CoV-2 registry (Analysis of Chronic Non-infectious Diseases Dynamics After COVID-19 Infection in Adult Patients). Assessment of impact of combined original comorbid diseases in patients with COVID-19 on the prognosis]

Author

Gregory P. Arutyunov, Ekaterina I. Tarlovskaya, Alexander G. Arutyunov, Yuri N. Belenkov, Alexandra O. Konradi, Yury M. Lopatin, Andrey P. Rebrov, Sergey N. Tereshchenko, Anna I. Chesnikova, Hamlet G. Hayrapetyan, Aleksandr P. Babin, Igor G. Bakulin, Natalia V. Bakulina, Larisa A. Balykova, Anna S. Blagonravova, Marina V. Boldina, Alexandra R. Vaisberg, Albert S. Galyavich, Veronika V. Gomonova, Natalia Yu. Grigorieva, Irina V. Gubareva, Irina V. Demko, Angelika V. Evzerikhina, Aleksandr V. Zharkov, Umida K. Kamilova, Zulfia F. Kim, Tatiana Yu. Kuznetsova, Natalia V. Lareva, Ekaterina V. Makarova, Svetlana V. Malchikova, Sergey V. Nedogoda, Marina M. Petrova, Ilya G. Pochinka, Konstantin V. Protasov, Denis N. Protsenko, Dmitry Yu. Ruzanau, Sergey A. Sayganov, Akpay S. Sarybaev, Natalia M. Selezneva, Akhmetzhan B. Sugraliev, Igor V. Fomin, Olga V. Khlynova, Olga Yu. Chizhova, Igor I. Shaposhnik, Dmitry A. Sh'ukarev, Айгуль K. Abdrahmanova, Susanna A. Avetisian, Hovhannes G. Avoyan, Karine K. Azarian, Galiya T. Aimakhanova, Dinara A. Ayipova, Almazbek Ch. Akunov, Marianna K. Alieva, Aliona V. Aparkina, Olga R. Aruslanova, Ekaterina Yu. Ashina, Olga Yu. Badina, Olga Yu. Barisheva, Alina S. Batchayeva, Anna M. Bitieva, Ismail U. Bikhteyev, Nataliya A. Borodulina, Maksim V. Bragin, Angela M. Budu, Galina M. Bykova, Kristina R. Vagapova, Darina D. Varlamova, Natalia N. Vezikova, Elena A. Verbitskaya, Olga E. Vilkova, Elena A. Vinnikova, Vera V. Vustina, Elena A. Galova, Vadim V. Genkel, Elena I. Gorshenina, Roman V. Gostishev, Elena V. Grigorieva, Ekaterina Yu. Gubareva, Gaukhar M. Dabylova, Anastasiya I. Demchenko, Oleg Yu. Dolgikh, Melis Y. Duyshobayev, Dmitrii S. Evdokimov, Ksenia E. Egorova, Anastasiia N. Ermilova, Aliya E. Zheldybayeva, Nataliya V. Zarechnova, Yuliia D. Zimina, Svetlana Yu. Ivanova, Elena Yu. Ivanchenko, Mariya V. Ilina, Maria V. Kazakovtseva, Elena V. Kazymova, Yuliya S. Kalinina, Nadezhda A. Kamardina, Anastasiya M. Karachenova, Igor A. Karetnikov, Nina A. Karoli, Magomed Kh. Karsiev, Daria S. Кaskaeva, Karina F. Kasymova, Zhainagul B. Kerimbekova, Ailar Sh. Kerimova, Eugeni S. Kim, Nina V. Kiseleva, Darya A. Klimenko, Anastasiia V. Klimova, Olga V. Kovalishena, Elena V. Kolmakova, Tatyana P. Kolchinskaya, Maria I. Kolyadich, Olga V. Kondriakova, Marina P. Konoval, Dmitryi Yu. Konstantinov, Elena A. Konstantinova, Vera A. Kordukova, Ekaterina V. Koroleva, Angelina Yu. Kraposhina, Tamara V. Kriukova, Alla S. Kuznetsova, Tatyana Yu. Kuzmina, Kirill V. Kuzmichev, Cholpon K. Kulchoroevna, Tatiana V. Kuprina, Irina M. Kouranova, Liliya V. Kurenkova, Natalia Yu. Kurchugina, Nadira A. Kushubakova, Valeriia I. Levankova, Natalia A. Lyubavina, Nadezhda A. Magdeyeva, Konstantin V. Mazalov, Viktoryia I. Majseenko, Aleksandra S. Makarova, Abdirashit M. Maripov, Anastasiia A. Marusina, Evgenii S. Melnikov, Nikita B. Moiseenko, Fazliniso N. Muradova, Rimma G. Muradyan, Shahane N. Musaelian, Anton O. Myshak, Ekaterina S. Nekaeva, Nataliia M. Nikitina, Bela B. Ogurlieva, Alla A. Odegova, Yuliia V. Omarova, Nazgul A. Omurzakova, Shynar O. Ospanova, Ekaterina V. Pahomova, Liviu D. Petrov, Svetlana S. Plastinina, Vera A. Pogrebetskaya, Dmitry S. Polyakov, Ekaterina V. Ponomarenko, Larisa L. Popova, Natalya A. Prokofeva, Inna A. Pudova, Nikita A. Rakov, Abdurakhmon N. Rahimov, Nadezhda A. Rozanova, Saltanat Serikbolkyzy, Andrei A Simonov, Valeriya V. Skachkova, Daria V. Soloveva, Irina A. Soloveva, Alexander K. Subbotin, Irina M. Sukhomlinova, Anastasiia G. Sushilova, Dilnoza R. Tagayeva, Yuliia V. Titojkina, Elena P. Tikhonova, Danil S. Tokmin, Anastasiia A. Tolmacheva, Mariya S. Torgunakova, Ksenia V. Trenogina, Natalia A. Trostianetckaia, Dmitriy A. Trofimov, Alexander A. Tulichev, Assiya T. Tursunova, Nina D. Ulanova, Oleg V. Fatenkov, Olga V. Fedorishina, Tatiana S. Fil, Irina Yu. Fomina, Irina S. Fominova, Irina A. Frolova, Svetlana M. Tsvinger, Vera V. Tsoma, Meerim B. Cholponbaeva, Tatiana I. Chudinovskikh, Olga A. Shevchenko, Tatyana V. Sheshina, Ekaterina A. Shishkina, Konstantin Yu. Shishkov, Stanislav Yu. Sherbakov, and Ekaterina A. Yausheva

Subjects
Adult, Male, Heart Failure, History, SARS-CoV-2, Endocrinology, Diabetes and Metabolism, COVID-19, Coronary Disease, General Medicine, Prognosis, Cardiovascular Diseases, Chronic Disease, Hypertension, Diabetes Mellitus, Humans, Female, Registries, Family Practice, Noncommunicable Diseases
Abstract

Study the impact of various combinations of comorbid original diseases in patients infected with COVID-19 later on the disease progression and outcomes of the new coronavirus infection.The ACTIV registry was created on the Eurasian Association of Therapists initiative. 5,808 patients have been included in the registry: men and women with COVID-19 treated at hospital or at home.gov ID NCT04492384.Most patients with COVID-19 have original comorbid diseases (oCDs). Polymorbidity assessed by way of simple counting of oCDs is an independent factor in negative outcomes of COVID-19. Search for most frequent combinations of 2, 3 and 4 oCDs has revealed absolute domination of cardiovascular diseases (all possible variants). The most unfavorable combination of 2 oCDs includes atrial hypertension (AH) and chronic heart failure (CHF). The most unfavorable combination of 3 oCDs includes AH, coronary heart disease (CHD) and CHF; the worst combination of 4 oCDs includes AH, CHD, CHF and diabetes mellitus. Such combinations increased the risk of lethal outcomes 3.963, 4.082 and 4.215 times respectively.Polymorbidity determined by way of simple counting of diseases may be estimated as a factor in the lethal outcome risk in the acute phase of COVID-19 in real practice. Most frequent combinations of 2, 3 and 4 diseases in patients with COVID-19 primarily include cardiovascular diseases (AH, CHD and CHF), diabetes mellitus and obesity. Combinations of such diseases increase the COVID-19 lethal outcome risk.Цель. Изучить влияние различных комбинаций сопутствующих заболеваний, существовавших у пациентов исходно, до инфицирования вирусом SARS-CoV-2, на тяжесть течения и исходы новой коронавирусной инфекции. Материалы и методы. Регистр АКТИВ создан по инициативе Евразийской ассоциации терапевтов. В регистр включены 5808 пациентов: мужчины и женщины с диагнозом COVID-19, находящиеся на лечении в стационаре или получающие лечение на дому. Регистрация регистра: идентификатор ClinicalTrials.gov: NCT04492384. Результаты. Подавляющее большинство пациентов с COVID-19 имеют исходные сопутствующие заболевания (иСЗ). Полиморбидность, оцененная методом простого подсчета иСЗ, является самостоятельным фактором негативного прогноза больных COVID-19. Поиск наиболее часто встречающихся комбинаций из 2, 3, 4 и более СЗ выявил абсолютное доминирование сердечно-сосудистых заболеваний во всех возможных вариантах. Наиболее неблагоприятной при сочетании 2 иСЗ была комбинация, включающая артериальную гипертензию (АГ) и хроническую сердечную недостаточность (ХСН), при сочетании 3 иСЗ комбинация, включающая АГ, ишемическую болезнь сердца (ИБС), ХСН, и при сочетании 4 иСЗ комбинация, включающая АГ, ИБС, ХСН и сахарный диабет. Наличие таких комбинаций приводило к росту риска летального исхода в 3,963, 4,082, 4,215 раза соответственно. Заключение. Полиморбидность, определенная методом простого подсчета заболеваний, может использоваться в реальной практике как фактор риска летальности в остром периоде COVID-19. В состав наиболее часто встречающихся комбинаций из 2, 3, 4 заболеваний у пациентов с COVID-19 входят преимущественно сердечно-сосудистые заболевания (АГ, ИБС, ХСН), сахарный диабет и ожирение. Комбинации этих заболеваний повышают риск летального исхода при COVID-19.

Published
2021

9. Analysis of influence of background therapy for comorbidities in the period before infection on the risk of the lethal COVID outcome. Data from the international ACTIV SARS-CoV-2 registry («Analysis of chronic non-infectious diseases dynamics after COVID-19 infection in adult patients SARS-CoV-2»)

Author

N V Lareva, A Sh Kerimova, D A Shсukarev, I. V. Fomin, I. A. Karetnikov, K. F. Kasymova, U. K. Kamilova, A. M. Budu, A O Konradi, A. A. Marusina, V. I. Majseenko, Yu D Zimina, E. V. Ponomarenko, E. V. Grigorieva, N. V. Bakulina, I. G. Pochinka, O. V. Kondriakova, N. A. Lyubavina, A. G. Sushilova, K. V. Protasov, E A Konstantinova, Yu. M. Lopatin, I I Shaposhnik, O. V. Karpov, I. A. Soloveva, N. V. Zarechnova, M. V. Bragin, G. T. Aimakhanova, O Yu Badina, O Yu Chizhova, A. P. Rebrov, D. V. Soloveva, E S Kim, V. I. Levankova, S. V. Malchikova, A. S. Galyavich, I. M. Sukhomlinova, M. B. Cholponbaeva, A. V. Klimova, A. R. Vaisberg, M. P. Konoval, V. V. Skachkova, N. N. Vezikova, E. A. Gаlova, N. A. Prokofeva, M Е Levin, L. A. Balykova, M. V. Kazakovtseva, A. S. Makarova, T. I. Chudinovskikh, K R Vagapova, A. K. Subbotin, N Yu Kurchugina, A. T. Tursunova, L. D. Petrov, O. R. Aruslanova, M V Ilina, Yu N Belenkov, I. V. Gubareva, E. S. Melnikov, G. A. Bykova, S Yu Ivanova, Yu V Titojkina, Z. F. Kim, A. V. Aparkina, D Yu Konstantinov, A. M. Maripov, K. V. Trenogina, Ch K. Kulchoroeva, E. A. Yausheva, S. S. Plastinina, N. D. Ulanova, D. D. Varlamova, E. V. Makarova, S. V. Nedogoda, R. V. Gostishev, A. P. Babin, A S Sarybaev, S. A. Avetisian, M. S. Torgunakova, G P Arutyunov, O. V. Fedorishina, L. V. Kurenkova, Sh O. Ospanova, G M Dabylova, E. I. Gorshenina, V V Genkel, N. M. Nikitina, M Kh Karsiev, R. G. Muradyan, M. V. Boldina, S Yu Sherbakov, A. A. Odegova, E. P. Tikhonova, M. I. Kolyadich, D. N. Protsenko, V. V. Gomonova, N. A. Karoli, T. V. Kuprina, N. B. Moiseenko, A O Myshak, K Yu Shishkov, N Yu Grigorieva, K. E. Egorova, A. N. Rakhimov, V. A. Pogrebetskaya, S. N. Tereshchenko, V. V. Vustina, I. U. Bikhteyev, N. A. Magdeyeva, Sh N. Musaelian, A. A. Tulichev, O. V. Khlynova, E. V. Kolmakova, A. I. Demchenko, E. V. Pahomova, I. A. Frolova, D. A. Trofimov, M. Y. Duyshobayev, A I Chesnikova, T. S. Fil, A. S. Kuznetsova, N. A. Kamardina, K. V. Kuzmichev, I. V. Demko, D. A. Klimenko, D. S. Evdokimov, O. E. Vilkova, K. V. Mazalov, A Ch Akunov, A. N. Ermilova, N. A. Rakov, B. B. Ogurlieva, O. V. Fatenkov, O. A. Shevchenko, A A Tolmacheva, E Yu Ashina, E. A. Vinnikova, D Yu Ruzanau, Zh B. Kerimbekova, A. K. Abdrahmanova, Yu S. Kalinina, T. V. Sheshina, I. G. Bakulin, Yu M. Omarova, A. V. Zharkov, I S Fominova, H. G. Hayrapetyan, L. A. Burygina, N. V. Kiseleva, A. M. Karachenova, A. M. Bitieva, D. S. Polyakov, T V Kriukova, F. M. Sokhova, A. G. Arutyunov, D. A. Ayipova, M. M. Petrova, M K Alieva, N. A. Borodulina, F. N. Muradova, I. A. Pudova, N A Kushubakova, A. A. Simonov, V. V. Tsoma, S. Serikbolkyzy, O Yu Barisheva, E. A. Shishkina, O. V. Kovalishena, L. L. Popova, A. V. Evzerikhina, A S Batchayeva, T Yu Kuzmina, K. K. Azarian, D. S. Tokmin, N. A. Omurzakova, D S Кaskaeva, A. E. Zheldybayeva, T. Yu. Kuznetsova, I Yu Fomina, E. A. Verbitskaya, N. A. Rozanova, D. R. Tagayeva, S. M. Tsvinger, E. Yu. Ivanchenko, S A Sayganov, N. A. Trostianetckaia, A. S. Blagonravova, A. Yu. Kraposhina, V. A. Kordukova, E. I. Tarlovskaya, O Yu Dolgikh, I. M. Kouranova, H. G. Avoyan, E. V. Kazymova, T. P. Kolchinskaya, N M Selezneva, A. B. Sugraliev, E. V. Koroleva, and E Yu Gubareva

Subjects
Adult, Male, medicine.medical_specialty, Population, Disease, Comorbidity, Lower risk, Pharmacotherapy, Internal medicine, medicine, Humans, Registries, education, Noncommunicable Diseases, Pandemics, education.field_of_study, COPD, business.industry, SARS-CoV-2, COVID-19, medicine.disease, Clopidogrel, Diabetes Mellitus, Type 2, Female, Cardiology and Cardiovascular Medicine, business, Ticagrelor, medicine.drug
Abstract

Aim To study the effect of regular drug therapy for cardiovascular and other diseases preceding the COVID-19 infection on severity and outcome of COVID-19 based on data of the ACTIVE (Analysis of dynamics of Comorbidities in paTIents who surVived SARS-CoV-2 infEction) registry.Material and methods The ACTIVE registry was created at the initiative of the Eurasian Association of Therapists. The registry includes 5 808 male and female patients diagnosed with COVID-19 treated in a hospital or at home with a due protection of patients’ privacy (data of nasal and throat smears; antibody titer; typical CT imaging features). The register territory included 7 countries: the Russian Federation, the Republic of Armenia, the Republic of Belarus, the Republic of Kazakhstan, the Kyrgyz Republic, the Republic of Moldova, and the Republic of Uzbekistan. The registry design: a closed, multicenter registry with two nonoverlapping arms (outpatient arm and in-patient arm). The registry scheduled 6 visits, 3 in-person visits during the acute period and 3 virtual visits (telephone calls) at 3, 6, and 12 mos. Patient enrollment started on June 29, 2020 and was completed on October 29, 2020. The registry completion is scheduled for October 29, 2022. The registry ID: ClinicalTrials.gov: NCT04492384. In this fragment of the study of registry data, the work group analyzed the effect of therapy for comorbidities at baseline on severity and outcomes of the novel coronavirus infection. The study population included only the patients who took their medicines on a regular basis while the comparison population consisted of noncompliant patients (irregular drug intake or not taking drugs at all despite indications for the treatment).ResultsThe analysis of the ACTIVE registry database included 5808 patients. The vast majority of patients with COVID-19 had comorbidities with prevalence of cardiovascular diseases. Medicines used for the treatment of COVID-19 comorbidities influenced the course of the infectious disease in different ways. A lower risk of fatal outcome was associated with the statin treatment in patients with ischemic heart disease (IHD); with angiotensin-converting enzyme inhibitors (ACEI)/angiotensin receptor antagonists and with beta-blockers in patients with IHD, arterial hypertension, chronic heart failure (CHF), and atrial fibrillation; with oral anticoagulants (OAC), primarily direct OAC, clopidogrel/prasugrel/ticagrelor in patients with IHD; with oral antihyperglycemic therapy in patients with type 2 diabetes mellitus (DM); and with long-acting insulins in patients with type 1 DM. A higher risk of fatal outcome was associated with the spironolactone treatment in patients with CHF and with inhaled corticosteroids (iCS) in patients with chronic obstructive pulmonary disease (COPD).Conclusion In the epoch of COVID-19 pandemic, a lower risk of severe course of the coronavirus infection was observed for patients with chronic noninfectious comorbidities highly compliant with the base treatment of the comorbidity.

Published
2021

10. ACTIV SARS-CoV-2 registry (Analysis of Chronic Non-infectious Diseases Dynamics After COVID-19 Infection in Adult Patients). Assessment of impact of combined original comorbid diseases in patients with COVID-19 on the prognosis

Author

Gregory P. Arutyunov, Ekaterina I. Tarlovskaya, Alexander G. Arutyunov, Yuri N. Belenkov, Alexandra O. Konradi, Yury M. Lopatin, Andrey P. Rebrov, Sergey N. Tereshchenko, Anna I. Chesnikova, Hamlet G. Hayrapetyan, Aleksandr P. Babin, Igor G. Bakulin, Natalia V. Bakulina, Larisa A. Balykova, Anna S. Blagonravova, Marina V. Boldina, Alexandra R. Vaisberg, Albert S. Galyavich, Veronika V. Gomonova, Natalia Yu. Grigorieva, Irina V. Gubareva, Irina V. Demko, Angelika V. Evzerikhina, Aleksandr V. Zharkov, Umida K. Kamilova, Zulfia F. Kim, Tatiana Yu. Kuznetsova, Natalia V. Lareva, Ekaterina V. Makarova, Svetlana V. Malchikova, Sergey V. Nedogoda, Marina M. Petrova, Ilya G. Pochinka, Konstantin V. Protasov, Denis N. Protsenko, Dmitry Yu. Ruzanau, Sergey A. Sayganov, Akpay S. Sarybaev, Natalia M. Selezneva, Akhmetzhan B. Sugraliev, Igor V. Fomin, Olga V. Khlynova, Olga Yu. Chizhova, Igor I. Shaposhnik, Dmitry A. Sh'ukarev, Айгуль K. Abdrahmanova, Susanna A. Avetisian, Hovhannes G. Avoyan, Karine K. Azarian, Galiya T. Aimakhanova, Dinara A. Ayipova, Almazbek Ch. Akunov, Marianna K. Alieva, Aliona V. Aparkina, Olga R. Aruslanova, Ekaterina Yu. Ashina, Olga Yu. Badina, Olga Yu. Barisheva, Alina S. Batchayeva, Anna M. Bitieva, Ismail U. Bikhteyev, Nataliya A. Borodulina, Maksim V. Bragin, Angela M. Budu, Galina M. Bykova, Kristina R. Vagapova, Darina D. Varlamova, Natalia N. Vezikova, Elena A. Verbitskaya, Olga E. Vilkova, Elena A. Vinnikova, Vera V. Vustina, Elena A. Galova, Vadim V. Genkel, Elena I. Gorshenina, Roman V. Gostishev, Elena V. Grigorieva, Ekaterina Yu. Gubareva, Gaukhar M. Dabylova, Anastasiya I. Demchenko, Oleg Yu. Dolgikh, Melis Y. Duyshobayev, Dmitrii S. Evdokimov, Ksenia E. Egorova, Anastasiia N. Ermilova, Aliya E. Zheldybayeva, Nataliya V. Zarechnova, Yuliia D. Zimina, Svetlana Yu. Ivanova, Elena Yu. Ivanchenko, Mariya V. Ilina, Maria V. Kazakovtseva, Elena V. Kazymova, Yuliya S. Kalinina, Nadezhda A. Kamardina, Anastasiya M. Karachenova, Igor A. Karetnikov, Nina A. Karoli, Magomed Kh. Karsiev, Daria S. Кaskaeva, Karina F. Kasymova, Zhainagul B. Kerimbekova, Ailar Sh. Kerimova, Eugeni S. Kim, Nina V. Kiseleva, Darya A. Klimenko, Anastasiia V. Klimova, Olga V. Kovalishena, Elena V. Kolmakova, Tatyana P. Kolchinskaya, Maria I. Kolyadich, Olga V. Kondriakova, Marina P. Konoval, Dmitryi Yu. Konstantinov, Elena A. Konstantinova, Vera A. Kordukova, Ekaterina V. Koroleva, Angelina Yu. Kraposhina, Tamara V. Kriukova, Alla S. Kuznetsova, Tatyana Yu. Kuzmina, Kirill V. Kuzmichev, Cholpon K. Kulchoroevna, Tatiana V. Kuprina, Irina M. Kouranova, Liliya V. Kurenkova, Natalia Yu. Kurchugina, Nadira A. Kushubakova, Valeriia I. Levankova, Natalia A. Lyubavina, Nadezhda A. Magdeyeva, Konstantin V. Mazalov, Viktoryia I. Majseenko, Aleksandra S. Makarova, Abdirashit M. Maripov, Anastasiia A. Marusina, Evgenii S. Melnikov, Nikita B. Moiseenko, Fazliniso N. Muradova, Rimma G. Muradyan, Shahane N. Musaelian, Anton O. Myshak, Ekaterina S. Nekaeva, Nataliia M. Nikitina, Bela B. Ogurlieva, Alla A. Odegova, Yuliia V. Omarova, Nazgul A. Omurzakova, Shynar O. Ospanova, Ekaterina V. Pahomova, Liviu D. Petrov, Svetlana S. Plastinina, Vera A. Pogrebetskaya, Dmitry S. Polyakov, Ekaterina V. Ponomarenko, Larisa L. Popova, Natalya A. Prokofeva, Inna A. Pudova, Nikita A. Rakov, Abdurakhmon N. Rahimov, Nadezhda A. Rozanova, Saltanat Serikbolkyzy, Andrei A Simonov, Valeriya V. Skachkova, Daria V. Soloveva, Irina A. Soloveva, Alexander K. Subbotin, Irina M. Sukhomlinova, Anastasiia G. Sushilova, Dilnoza R. Tagayeva, Yuliia V. Titojkina, Elena P. Tikhonova, Danil S. Tokmin, Anastasiia A. Tolmacheva, Mariya S. Torgunakova, Ksenia V. Trenogina, Natalia A. Trostianetckaia, Dmitriy A. Trofimov, Alexander A. Tulichev, Assiya T. Tursunova, Nina D. Ulanova, Oleg V. Fatenkov, Olga V. Fedorishina, Tatiana S. Fil, Irina Yu. Fomina, Irina S. Fominova, Irina A. Frolova, Svetlana M. Tsvinger, Vera V. Tsoma, Meerim B. Cholponbaeva, Tatiana I. Chudinovskikh, Olga A. Shevchenko, Tatyana V. Sheshina, Ekaterina A. Shishkina, Konstantin Yu. Shishkov, Stanislav Yu. Sherbakov, and Ekaterina A. Yausheva

Subjects
covid-19, activ registry, cardiovascular diseases, diabetes mellitus, polymorbidity, disease combinations, Medicine
Abstract

Aim. Study the impact of various combinations of comorbid original diseases in patients infected with COVID-19 later on the disease progression and outcomes of the new coronavirus infection. Materials and methods. The ACTIV registry was created on the Eurasian Association of Therapists initiative. 5,808 patients have been included in the registry: men and women with COVID-19 treated at hospital or at home. ClinicalTrials.gov ID NCT04492384. Results. Most patients with COVID-19 have original comorbid diseases (oCDs). Polymorbidity assessed by way of simple counting of oCDs is an independent factor in negative outcomes of COVID-19. Search for most frequent combinations of 2, 3 and 4 oCDs has revealed absolute domination of cardiovascular diseases (all possible variants). The most unfavorable combination of 2 oCDs includes atrial hypertension (AH) and chronic heart failure (CHF). The most unfavorable combination of 3 oCDs includes AH, coronary heart disease (CHD) and CHF; the worst combination of 4 oCDs includes AH, CHD, CHF and diabetes mellitus. Such combinations increased the risk of lethal outcomes 3.963, 4.082 and 4.215 times respectively. Conclusion. Polymorbidity determined by way of simple counting of diseases may be estimated as a factor in the lethal outcome risk in the acute phase of COVID-19 in real practice. Most frequent combinations of 2, 3 and 4 diseases in patients with COVID-19 primarily include cardiovascular diseases (AH, CHD and CHF), diabetes mellitus and obesity. Combinations of such diseases increase the COVID-19 lethal outcome risk.

Published
2022
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