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1,869 results on '"A. Maillo"'

1. Chagas disease in Europe

Author

Gonzalez-Sanz, Marta, Crespillo-Andujar, Clara, Chamorro-Tojeiro, Sandra, Monge-Maillo, Begona, Perez-Molina, Jose A, and Norman, Francesca F

Published
2023

3. Author Correction: Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approach

Author

Villar, Silvina R., Herreros-Cabello, Alfonso, Callejas-Hernández, Francisco, Maza, María C., del Moral-Salmoral, Javier, Gómez-Montes, Mario, Rodríguez-Angulo, Héctor O., Carrillo, Irene, Górgolas, Miguel, Bosch-Nicolau, Pau, Molina, Israel, Pérez-Molina, José A., Monge-Maillo, Begoña, Bottasso, Oscar A., Beloscar, Juan, Pérez, Ana R., Fresno, Manuel, and Gironès, Núria

Published
2024
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5. Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approach

Author

Villar, Silvina R., Herreros-Cabello, Alfonso, Callejas-Hernández, Francisco, Maza, María C., del Moral-Salmoral, Javier, Gómez-Montes, Mario, Rodríguez-Angulo, Héctor O., Carrillo, Irene, Górgolas, Miguel, Bosch-Nicolau, Pau, Molina, Israel, Pérez-Molina, José A., Monge-Maillo, Begoña, Bottasso, Oscar A., Beloscar, Juan, Pérez, Ana R., Fresno, Manuel, and Gironès, Núria

Published
2024
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6. IHCV: Discovery of Hidden Time-Dependent Control Variables in Non-Linear Dynamical Systems

Author

Munoz, Juan, Balsamy, Subash, Bernal-Tamayo, Juan P., Balubaid, Ali, de Infante, Alberto Maillo Ruiz, Lagani, Vincenzo, Gomez-Cabrero, David, Kiani, Narsis A., and Tegner, Jesper

Subjects
Quantitative Biology - Quantitative Methods, Mathematics - Dynamical Systems, 37M20
Abstract

Discovering non-linear dynamical models from data is at the core of science. Recent progress hinges upon sparse regression of observables using extensive libraries of candidate functions. However, it remains challenging to model hidden non-observable control variables governing switching between different dynamical regimes. Here we develop a data-efficient derivative-free method, IHCV, for the Identification of Hidden Control Variables. First, the performance and robustness of IHCV against noise are evaluated by benchmarking the IHCV method using well-known bifurcation models (saddle-node, transcritical, pitchfork, Hopf). Next, we demonstrate that IHCV discovers hidden driver variables in the Lorenz, van der Pol, Hodgkin-Huxley, and Fitzhugh-Nagumo models. Finally, IHCV generalizes to the case when only partial observational is given, as demonstrated using the toggle switch model, the genetic repressilator oscillator, and a Waddington landscape model. Our proof-of-principle illustrates that utilizing normal forms could facilitate the data-efficient and scalable discovery of hidden variables controlling transitions between different dynamical regimes and non-linear models., Comment: 12 pages, 2 figures

Published
2023

7. Identification of Chagas disease biomarkers using untargeted metabolomics

Author

Alfonso Herreros-Cabello, Pau Bosch-Nicolau, José A. Pérez-Molina, Fernando Salvador, Begoña Monge-Maillo, Jose F. Rodriguez-Palomares, Antonio Luiz Pinho Ribeiro, Adrián Sánchez-Montalvá, Ester Cerdeira Sabino, Francesca F. Norman, Manuel Fresno, Núria Gironès, and Israel Molina

Subjects
Chagas disease, Untargeted metabolomics, Biomarkers, Chronic chagasic cardiomyopathy, Medicine, Science
Abstract

Abstract Untargeted metabolomic analysis is a powerful tool used for the discovery of novel biomarkers. Chagas disease (CD), caused by Trypanosoma cruzi, is a neglected tropical disease that affects 6–7 million people with approximately 30% developing cardiac manifestations. The most significant clinical challenge lies in its long latency period after acute infection, and the lack of surrogate markers to predict disease progression or cure. In this cross-sectional study, we analyzed sera from 120 individuals divided into four groups: 31 indeterminate CD, 41 chronic chagasic cardiomyopathy (CCC), 18 Latin Americans with other cardiomyopathies and 30 healthy volunteers. Using a high-throughput panel of 986 metabolites, we identified three distinct profiles among individuals with cardiomyopathy, indeterminate CD and healthy volunteers. After a more stringent analysis, we identified some potential biomarkers. Among peptides, phenylacetylglutamine and fibrinopeptide B (1–13) exhibited an increasing trend from controls to ICD and CCC. Conversely, reduced levels of bilirubin and biliverdin alongside elevated urobilin correlated with disease progression. Finally, elevated levels of cystathionine, phenol glucuronide and vanillactate among amino acids distinguished CCC individuals from ICD and controls. Our novel exploratory study using metabolomics identified potential biomarker candidates, either alone or in combination that if confirmed, can be translated into clinical practice.

Published
2024
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8. Screening blood donors for malaria, can we increase the number of eligible donors? An observational retrospective study

Author

María Dolores Corbacho-Loarte, Oihane Martín, Sandra Chamorro-Tojeiro, Clara Crespillo-Andújar, Francesca F. Norman, José A. Pérez-Molina, Marta González Sanz, Marta Rosas Cancio-Suárez, Gabriel Ruiz-Calvo, Alberto Richart López, José Miguel Rubio, Rogelio López-Vélez, and Begoña Monge-Maillo

Subjects
Transfusion, Malaria, Plasmodium, Asymptomatic infection, Immigrants, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background In non-endemic countries, malaria can be transmitted through blood donations from imported cases. To ensure standards of quality and safety of human blood, the European Union and Spanish national law, requires a deferral period, or a screening by immunological or genomic test among those donors with potential risk of malaria. Scientific societies, European Committee on Blood Transfusion, and Spanish Society of Haematology and Haemotherapy, refer only to the result of the immunological test. Methods An observational retrospective study was performed in potential donors with a positive immunological test for malaria done in the Regional Transfusion Center in Madrid and referred to the National Reference Unit for Tropical Diseases in Madrid between 2015–2020. At consultation a Polymerase Chain Reaction (PCR) for malaria was performed. Results During the study period, 121 possible donors attended for consultation at NRU-Trop. Median age: 38.5 (IQR:33–48); median time to consultation was 32 months (IQR:12.5–110). Eighty-two (67.8%) donors were migrants and thirty-nine were travellers (32.2%). ELISA values were available for 109 subjects (90.1%), 56 individual left malaria endemic area > 3 years before. All donors tested negative for Plasmodium spp PCR test (n = 121, 100%). Conclusions None of the subjects with a positive immunologic test deferred as blood donors had a positive genomic test. The presence of Plasmodium spp in collected blood was not detected by molecular techniques. To avoid the loss of potential blood donors, especially those with low incidence red blood cell antigens, as more precise microbiology techniques become available, updating the existing legislation becomes necessary to increase the availability of donated blood.

Published
2024
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12. Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approach

Author

Silvina R. Villar, Alfonso Herreros-Cabello, Francisco Callejas-Hernández, María C. Maza, Javier del Moral-Salmoral, Mario Gómez-Montes, Héctor O. Rodríguez-Angulo, Irene Carrillo, Miguel Górgolas, Pau Bosch-Nicolau, Israel Molina, José A. Pérez-Molina, Begoña Monge-Maillo, Oscar A. Bottasso, Juan Beloscar, Ana R. Pérez, Manuel Fresno, and Núria Gironès

Subjects
Medicine, Science
Abstract

Abstract Chagas disease affects approximately 7 million people worldwide in Latin America and is a neglected tropical disease. Twenty to thirty percent of chronically infected patients develop chronic Chagas cardiomyopathy decades after acute infection. Identifying biomarkers of Chagas disease progression is necessary to develop better therapeutic and preventive strategies. Circulating microRNAs are increasingly reliable biomarkers of disease and therapeutic targets. To identify new circulating microRNAs for Chagas disease, we performed exploratory small RNA sequencing from the plasma of patients and performed de novo miRNA prediction, identifying potential new microRNAs. The levels of the new microRNAs temporarily named miR-Contig-1519 and miR-Contig-3244 and microRNAs that are biomarkers for nonchagasic cardiomyopathies, such as miR-148a-3p and miR-224-5p, were validated by quantitative reverse transcription. We found a specific circulating microRNA signature defined by low miR-Contig-3244, miR-Contig-1519, and miR-148a-3 levels but high miR-224-5p levels for patients with chronic Chagas disease. Finally, we predicted in silico that these altered circulating microRNAs could affect the expression of target genes involved in different cellular pathways and biological processes, which we will explore in the future.

Published
2024
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15. Ongoing CPR with an onboard physician

Author

Sucunza, Alfredo Echarri, Fernández del Valle, Patricia, Vázquez, Jose Antonio Iglesias, Azeli, Youcef, Navalpotro Pascual, Jose María, Rodriguez, Juan Valenciano, Barreras, Cristian Fernández, Embid, Sonia Royo, Gutiérrez-García, Carmen, Rozalén, María Isabel Ceniceros, García, Cesar Manuel Guerra, del Pozo Pérez, Carmen, Luque-Hernández, María José, Muñoz, Silvia Sola, Canos, Ana Belén Forner, Maíllo, María Isabel Herrera, García, Marcos Juanes, García, Natividad Ramos, Isabel, Belén Muñoz, Mendoza, Junior Jose García, Ramas, José Antonio Cortés, Revilla, Faustino Redondo, Mateo-Rodríguez, Inmaculada, Sanz, Félix Rivera, Knox, Emily, Codina, Antonio Daponte, Azpiazu, José Ignacio Ruiz, and Ortiz, Fernando Rosell

Published
2024
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16. Author Correction: Discovery of circulating miRNAs as biomarkers of chronic Chagas heart disease via a small RNA-Seq approach

Author

Silvina R. Villar, Alfonso Herreros-Cabello, Francisco Callejas-Hernández, María C. Maza, Javier del Moral-Salmoral, Mario Gómez-Montes, Héctor O. Rodríguez-Angulo, Irene Carrillo, Miguel Górgolas, Pau Bosch-Nicolau, Israel Molina, José A. Pérez-Molina, Begoña Monge-Maillo, Oscar A. Bottasso, Juan Beloscar, Ana R. Pérez, Manuel Fresno, and Núria Gironès

Subjects
Medicine, Science
Published
2024
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18. 3D Technology Applied on Complex Abdominal Wall Pathologies

Author

Torres Villachica, Jose A., Sánchez Tabernero, Álvaro, Coelho Morais, Tiago, Montejo Mailló, Beatriz, Juanes Mendez, Juan A., Huang, Ronghuai, Series Editor, Kinshuk, Series Editor, Jemni, Mohamed, Series Editor, Chen, Nian-Shing, Series Editor, Spector, J. Michael, Series Editor, García-Peñalvo, Francisco José, editor, and García-Holgado, Alicia, editor

Published
2023
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26. Developing the University of Tartu in Estonia into a well-networked Patient Safety Research Centre (PATSAFE): A study protocol [version 2; peer review: 1 approved, 2 approved with reservations]

Author

Mari Kangasniemi, Helena Vall-Roqué, Joel Starkopf, Siim Läänelaid, Hub Wollersheim, Anne van Tuijl, Liisi Mägi, Tiina Freimann, María del Mar Fernández-Maillo, Joaquim Bañeres, Margus Lember, Yvette Emond, Kaja PÕLLUSTE, Carola Orrego, Hiske Calsbeek, Rosa Suñol, and Marta Ballester

Subjects
Patient safety, research competences, early-stage researchers, research strategy, knowledge exchange., eng, Science, Social Sciences
Abstract

Background Patient safety (PS) is a serious global public health problem affecting all countries. Estimates show that around 10 percent of the patients are harmed during hospital care, resulting in 23 million disability-adjusted life years lost per year. Experts emphasize research advancements as a key precondition for safer care. Aim The Patient Safety Research Centre (PATSAFE) project enhances the Institute of Clinical Medicine of the University of Tartu’s (ICM-UT) research potential and capacities in PS in order to improve and strengthen knowledge and skills in methods, techniques and experience for PS research. Methods A strategic partnership with Avedis Donabedian Research Institute in Spain, and IQ Healthcare in the Netherlands, both international leaders in PS research, enables the development of a long-lasting knowledge exchange, allowing the ICM-UT to capitalise on its current achievements and to overcome gaps in scientific excellence in the field of PS research. These twining activities will strengthen and raise the research profile of the ICM-UT academic staff and early-stage researchers (ESRs), by implementing the hands-on training on methods, techniques, and experience in PS research. The project also encourages the active participation of ESRs in PS research by increasing their soft skills, to ensure the continuity and sustainability of PS research in ICM-UT. Finally, development of the research strategy on PS contributes to the long-term sustainability of PS research in Estonia. To implement these activities, PATSAFE foresees a comprehensive strategy consisting of knowledge exchange, soft research skills capacity building, strategic planning, and strong dissemination and exploitation efforts. Expected results As a result of the project, ICM-UT will have the capacity to carry out PS research using the appropriate methodology and the competences to apply state-of-the-art evidence-based strategies for PS research.

Published
2023
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27. Democracia y desinformación : Nuevas formas de polarización, discursos de odio y campañas en redes. Respuestas regulatorias de Europa y América Latina

Author

Maíllo, Isabel Serrano, Corredoira, Loreto, Anguita, Pedro, de Andrade Monteiro, Vitor, Jimeno, Tamara Antona, Ferrer, Ferran Armengol, Rueda, Altus Alejandro Baquero, Bernad, Javier Barriuso, Bel, Ignacio, Presuel, Rodrigo Cetina, Martínez, Mariluz Congosto, Fedchenko, Yevhen, Gómez, Rocío, Aguilar, Juan Manuel Gozález, Gonzalo, Miguel Ángel, Jans, Alejandra, Castro, Oscar Jaramillo, Blanes, María José Labrador, Mayagoitia-Soria, Ana, Sánchez, Adrián Merinero, Osuna, José Javier Olivas, Rebollo, María Antonia Paz, Portero, Florentino, Núñez, Rafael Rubio, Molina, José Manuel Saavedra, Boj, Francisco Segado, Díaz, Nairbis Desiree Sibrian, Vincent-Ibáñez, Mireya, Camacho, Jessica Zorogastua, Maíllo, Isabel Serrano, Corredoira, Loreto, Anguita, Pedro, de Andrade Monteiro, Vitor, Jimeno, Tamara Antona, Ferrer, Ferran Armengol, Rueda, Altus Alejandro Baquero, Bernad, Javier Barriuso, Bel, Ignacio, Presuel, Rodrigo Cetina, Martínez, Mariluz Congosto, Fedchenko, Yevhen, Gómez, Rocío, Aguilar, Juan Manuel Gozález, Gonzalo, Miguel Ángel, Jans, Alejandra, Castro, Oscar Jaramillo, Blanes, María José Labrador, Mayagoitia-Soria, Ana, Sánchez, Adrián Merinero, Osuna, José Javier Olivas, Rebollo, María Antonia Paz, Portero, Florentino, Núñez, Rafael Rubio, Molina, José Manuel Saavedra, Boj, Francisco Segado, Díaz, Nairbis Desiree Sibrian, Vincent-Ibáñez, Mireya, and Camacho, Jessica Zorogastua

Published
2024

28. El podcast como herramienta de enseñanza y aprendizaje. El Derecho de viva voz

Author

Serrano Maillo, María Isabel, Abad Alcalá, Leopoldo, Ballesteros Valero, Francisco, Burgos Martín, Teba, Cousido González, María Pilar, Serrano Tárraga, María Dolores, Garrote Marcos, María de los Ángeles, Fernández Riveira, Rosa María, Gaete Salgado, Catalina Andrea, Galván Jerez, Sol, García Pozo, Marta, García- Poggio Baeza, Paz, Gordo Martín, Daniel, Herranz Calvo, Félix, Martín de Llano, Isabel, Martínez Pastor, Esther, Molero Alonso, Diego Julián, Muñoz Carrasco, Patricia, Oliva Santos, Blanca, Pérez Sánchez, María Cristina, Serrano Maillo, Alfonso, Serrano Maillo, María Isabel, Abad Alcalá, Leopoldo, Ballesteros Valero, Francisco, Burgos Martín, Teba, Cousido González, María Pilar, Serrano Tárraga, María Dolores, Garrote Marcos, María de los Ángeles, Fernández Riveira, Rosa María, Gaete Salgado, Catalina Andrea, Galván Jerez, Sol, García Pozo, Marta, García- Poggio Baeza, Paz, Gordo Martín, Daniel, Herranz Calvo, Félix, Martín de Llano, Isabel, Martínez Pastor, Esther, Molero Alonso, Diego Julián, Muñoz Carrasco, Patricia, Oliva Santos, Blanca, Pérez Sánchez, María Cristina, and Serrano Maillo, Alfonso

Abstract

Serie de podcast jurídicos con un fin divulgativo. En los últimos tiempos se ha hecho patente la necesidad de explicar el Derecho de una manera más cercana, imparcial y accesible: el qué y el porqué de algunas las leyes, la función de los jueces, la explicación de ciertas penas, etc… Es necesario explicar el Derecho de manera que todos puedan entenderlo, empezando por nuestras y nuestros estudiantes, aunque no exclusivamente. Hemos optado por el formato podcast porque nos parece una manera actual, accesible e inclusiva de enseñar. Se trata de enseñar Derecho de una manera amena. Hay más proyectos de este tipo (por ejemplo: Café Jurídico: https://cafejuridico.es/; Tertulia jurídica: https://open.spotify.com/show/2B4wGYx5rVulH2BLvQhvOG?si=5f72b8b98ed147ab; Almacén de Derecho: https://almacendederecho.org/podcasts, entre otros), pero todos adolecen –desde nuestro punto vista- del mismo problema: Son demasiado teóricos y el lenguaje es demasiado técnico. Nuestro objetivo es acercar el mundo del derecho al público en general. A todas aquellas personas que son legas en Derecho pero que se interesan por los temas jurídicos de actualidad. Que quieren entender el porqué de lo que pasa, que tiene curiosidad por comprender todo lo que ocurre en el Parlamento o en los Juzgados, qué hace que se imponga una pena u otra, etc. Así, para poder hacer un producto de calidad y accesible a todo el mundo, en nuestro equipo contamos no solo con juristas y profesores de reconocido prestigio, sino también con periodistas, alumnos y alumnas de comunicación (grado y doctorado) y personas de la sociedad civil que actuarán como asesores temáticos. Creemos que es necesario que existan todos estos perfiles (junto con el de técnicos, obviamente) porque a veces desde la Academia perdemos la perspectiva social y es una “pata” esencial si queremos que el resultado de nuestro proyecto tenga realmente un carácter divulgativo. Se plantea una serie de podcasts. Cada podcast tendrá una duración de 20-30 m

Published
2024

33. Onomatopoeia, gestures, actions and words:How do caregivers use multimodal cues in their communication to children?

Author

Vigliocco, Gabriella, Motamedi, Yasamin, Murgiano, Margherita, Wonnacott, Elizabeth, Marshall, Chloe, Maillo, Iris Milan, and Perniss, Pamela

Subjects
language development, word learning, iconicity, onomatopoeia, co-speech gestures, child directed speech, naturalistic observation.
Abstract

Most research on how children learn the mapping betweenwords and world has assumed that language is arbitrary, andhas investigated language learning in contexts in which objectsreferred to are present in the environment. Here, we reportanalyses of a semi-naturalistic corpus of caregivers talking totheir 2-3 year-old. We focus on caregivers’ use of non-arbitrarycues across different expressive channels: both iconic(onomatopoeia and representational gestures) and indexical(points and actions with objects). We ask if these cues are useddifferently when talking about objects known or unknown tothe child, and when the referred objects are present or absent.We hypothesize that caregivers would use these cues moreoften with objects novel to the child. Moreover, they would usethe iconic cues especially when objects are absent becauseiconic cues bring to the mind’s eye properties of referents. Wefind that cue distribution differs: all cues except points are morecommon for unknown objects indicating their potential role inlearning; onomatopoeia and representational gestures are morecommon for displaced contexts whereas indexical cues aremore common when objects are present. Thus, caregiversprovide multimodal non-arbitrary cues to support children’svocabulary learning and iconicity – specifically – can supportlinking mental representations for objects and labels.

Published
2019

35. LA FAMILIA

Author

de la Cigoña, Carmen Fernández, primary and Maillo, Carmen Sánchez, additional

Published
2022
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36. Prevalence of bleeding secondary to anticoagulation and mortality in patients with atrial fibrillation admitted with SARS-CoV-2 infection

Author

Rubini-Costa, Ricardo, Bermúdez-Jiménez, Francisco, Rivera-López, Ricardo, Sola-García, Elena, Nagib-Raya, Hadi, Moreno-Escobar, Eduardo, López-Zúñiga, Miguel Ángel, Briones-Través, Adela, Sanz-Herrera, Francisco, Sequí-Sabater, Jose Miguel, Romero-Cabrera, Juan Luis, Maíllo-Seco, Javier, Fernández-Vázquez, Felipe, Rivadeneira-Ruiz, María, López-Valero, Lucas, Gómez-Navarro, Carlos, Aparicio-Gómez, Jose Antonio, López, Miguel Álvarez, Tercedor, Luis, Molina-Jiménez, María, Macías-Ruiz, Rosa, and Jiménez-Jáimez, Juan

Published
2022
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37. Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses

Author

Pan, Hongchao, Peto, Richard, Henao Restrepo, Ana Maria, Preziosi, Marie-Pierre, Sathiyamoorthy, Vasee, Karim, Quarraisha Abdool, Alejandria, Marissa, Hernàndez García, César, Kieny, Marie-Paule, Malekzadeh, Reza, Murthy, Srinivas, Reddy, K. Srinath, Periago, Mirta Roses, Hanna, Pierre Abi, Abutidze, Akaki, Ader, Florence, Al-Bader, Abdullah, Alhasawi, Almonther, Allum, Emma, Al Mawali, Adhra, Alotaibi, Athari, Alvarez- Moreno, Carlos, Appadoo, Sheila, Arts, Derk, Asiri, Abdullah, Aukrust, Pål, Barratt-Due, Andreas, Genetu Bayih, Abebe, Beaumont, Helena, Bellani, Samir, Benassi, Virginia, Bhargava, Balram, Branca, Mattia, Cappel-Porter, Heike, Cerrato, Nery, Cheick Haidara, Fadima, Chow, Ting Soo, Como, Nadia, Eustace, Joe, Gabunia, Tamar, García, Patricia, Godbole, Sheela, Gotuzzo, Eduardo, Griskevicius, Laimonas, Hamra, Rasha, Hassan, Mariam, Hassany, Mohamed, Hutton, David, Irmansyah, Irmansyah, Jancoriene, Ligita, Khamis, Faryal, Kirwan, Jana, Kumar, Suresh, Lennon, Peter, Lopardo, Gustavo, Lydon, Patrick, Magrini, Nicola, Manevska, Suzana, Manuel, Oriol, McGinty, Sybil, Medina, Marco, Mesa Rubio, Maria Lucia, Miranda Montoya, Maria Consuelo, Nel, Jeremy, Nunes, Estevao, Perola, Markus, Portoles, Antonio, Rasmin, Menaldi, Raza, Aun, Rees, Helen, Reges, Paula, Rogers, Chris, Salami, Kolawole, Salvadori, Marina, Sauermann, Mamatha, Sinani, Narvina, Sow, Samba, Sterne, Jonathan AC, Stevanovikj, Milena, Tacconelli, Evelina, Tavares Maltez, Fernando Manuel, Teferi, Mekonnen, Tikkinen, Kari, Trelle, Sven, Tsertsvadze, Tengiz, Zaid, Hala, Røttingen, John-Arne, Swaminathan, Soumya, Ryan, Michael, Gjermeni, Nevila, Meta, Esmeralda, Aguila, Damian, Alonso, Ignacio, Altamirano, Marcos, Alvarez, María, Alzola, Rodrigo, Arce, Veronica, Arribillaga, Patricia, Avila, Rafael, Balbuena, Juan, Barcelona, Laura, Barletta, José, Benedetti, María, Berdiñas, Verónica, Burgui, Julieta, Caimi, Sabrina, Carrillo, Juan, Carrizo, Juan, Castelli, Juan, Cazaux, Alexis, Cervellino, Flavia, Chalco, Angelo, Chediack, Viviana, Cunto, Eleonora, D'Amico, Nicolàs, de Vedia, Lautaro, Delgado, Carolina, Di Pilla, Debora, Díaz, Miguel, Díaz Aguiar, Pablo, Domínguez, Cecilia, Ellero, Leonor, Farina, Javier, Fernàndez, José, Ferreyra, Roxana, Filippi, María, Fogar, Carolina, Frare, Pablo, Giudiche, Celeste, Golikow, Mariana, Gomez, Maria Georgina, Hermida, Laura, Hurtado, Mariano, Jacobo, Mariela, Jaume, Martin, Laplume, Diego, Lescano, María, Lista, Nicolàs, Loiacono, Flavia, López, Ana Belen, Losso, Marcelo, Luna, Cecilia, Lupo, Sergio, Marianelli, Leonardo, Martin, Anabella, Masciottra, Florencia, Mykietiuk, Analía, Orellano, Lorena, Pachioli, Valeria, Padilla, María José, Pallavicini, Cecilia, Patroso, Jazmin, Perez Blanco, Luz, Presas, Jose Louis, Provenzano, Matias, Lavera, Lorena, Reichert, Viviana, Riveros, Florencia, Rodríguez, Alejandra, Rolon, María José, Salvay, Carolina, Simonetta, María, Sisto, Alicia, Themines, Sandra, Tito, Fernando, Toibaro, Javier, Torales, Graciela, Verón, Luciano, Vizzotti, Carla, Egle, Alexander, Greil, Richard, Joannidis, Michael, Altdorfer, Antoine, Belkhir, Leila, Fraipont, Vincent, Hites, Maya, Arruda, Erico, Breda, Giovanni, Colussi, Arthur, Corradi, Miran, Croda, Julio, Duani, Helena, João, Esaú, Machado, Elizabeth, Mello, Fernanda, Miranda Filho, Demócrito, Monteiro, Poliana, Nunes, Ceuci, Pereira Junior, Luiz Carlos, Pinto, Gustavo, Raboni, Sonia, Ramos, Marcelo, Ruffing, Leonardo, Santos, Valdilea, Souza, Tamara, Medeiros, Melissa, Schwarzbold, Alexandre, Ali, Karim, Azher, Tanweer, Bellemare, David, Binnie, Alexandra, Borgia, Sergio, Cavayas, Yiorgos Alexandros, Chagnon, Nicholas, Cheng, Matthew, Cloutier, Eve, Conly, John, Costiniuk, Cecilia, Daneman, Nick, Douglas, James, Downey, Catarina, Duan, Erick, Durand, Medeline, English, Shane, Farjou, George, Fera, Evadiki, Fontela, Patricia, Fowler, Rob, Fralick, Mike, Gamble, David Gregory, Geagea, Anna, Grant, Jennifer, Harrison, Luke, Havey, Thomas, Hoang, Holly, Kelly, Lauren, Keynan, Yoav, Khwaja, Kosar, Klein, Marina, Kolan, Christophe, Kronfli, Nadine, Lamontagne, Francois, Lee, Nelson, Lee, Todd, Lim, Rachel, Lostun, Alexandra, MacIntyre, Erika, Malhamé, Isabelle, Martin-Carrier, Francois, McGuinty, Marlee, Munan, Matthew, O'Neil, Conar, Ovakim, Daniel, Papenburg, Jesse, Parhar, Ken, Parvathy, SeemaNair, Perez-Patrigeon, Santiago, Rishu, Asgar, Rushton, Moira, Scherr, Kim, Schwartz, Kevin, Semret, Makeda, Silverman, Micahel, Singh, Ameeta, Sligl, Wendy, Smith, Stephanie, Somayaji, Ranjani, Tan, Darrell, Tran, Tuong-Vi, Tremblay, Alain, Tsang, Jennifer, Turgeon, Alexis, Vakil, Erik, Weatherald, Jason, Yansouni, Cedric, Zarychanski, Ryan, Aristizabal, Claudia, Bravo, Juan, Caicedo, Monica, Chacón, Julio, Garzón, Diego, Guevara, Fredy, Lozano-Gonzàlez, Silvia, Macareno, Hugo, Montañez-Ayala, Anita, Oñate, Jose, Rojas-Gambasica, Jose, Rosso, Fernando, Saavedra, Carlos, Valderrama, Sandra, Vàquiro-Herrera, Eliana, Varón-Vega, Fabio, Zuluaga, Ivan, Abdel Baki, Amin, Abdelbary, Akram, Abdel-Razek, Wael, Amin, Wagdi, Asem, Noha, Elassal, Gehan, Elshesheny, Marwa, Fathy, Mohamed, Fathy, Naglaa, Fayed, Notaila, Hammam, Ahmed, Hassany, Sahar, Ibrahim, Hamdy, Kamal, Ehab, Masoud, Hossam, Mohamed, Maryam, Mohamed Gouda, Abdullah, Moustafa, Ehab, Okasha, Shaimaa, Rafik, Ahmed, Said, Ahmed, Sedky, Asmaa, Solyman Kabil, Mohamed, Tarek, Sara, Tharwat, Ahmed, Zaky, Samy, Abegaz, Emawayish Tesema, Bekele, Zelalem Mekonnen, Asfaw, Filmona Mekuria, Tegegne, Netsanet Aragaw, Teklemariam, Miheret Fikre, Nigusse, Frehiwot Tamiru, Achalu, Daniel Legesse, Weldegergs, Shewit Tesfagabr, Huluka, Dawit Kebede, Tereda, Addisu Birhanu, Ala-Kokko, Tero, Delany, Jutta, Ekroos, Heikki, Hankkio, Riina, Haukipää, Mia, Hetemäki, Iivo, Holma, Pia, Holmberg, Ville, Horstia, Saana, Jalkanen, Ville, Jämsänen, Toni, Järventie, Juuso, Järvinen, Petrus, Kalliala, Ilkka, Kauma, Heikki, Kilpeläinen, Tuomas, Kreivi, Hanna-Riikka, Kuitunen, Ilari, Lamminmäki, Satu, Mäkinen, Laura, Mäntylä, Jarkko, Mattila, Tiina, Myllärniemi, Marjukka, Niskanen, Joni, Nykänen, Taina, Nyqvist, Miro, Paajanen, Juuso, Partanen, Terhi, Patovirta, Riitta-Liisa, Paukkeri, Erja-Leena, Puusti, Emmi, Renner, Andreas, 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Dastan, Farzaneh, Ebrahimpour, Soheil, Eghtesad, Sareh, Fallahi, Mohammad Javad, Fallahpoor Golmaee, Fatemeh, Foroghi Ghomi, Seyed Yaser, Ghadir, Mohammad Reza, Gheitani, Mina, Ghiasvand, Fereshteh, Hafizi Lotfabadi, Saied, Hakamifard, Atousa, Hashemi Madani, Shima Sadat, Hormati, Ahmad, Hosseini, Hamed, Janbakhsh, Alireza, Javanian, Mostafa, Joukar, Farahnaz, Kamali, Alireza, Karampour, Amin, Khajavirad, Nasim, Khodabakhshi, Behnaz, Khodadadi, Javad, Khodashahi, Rozita, Kiani Majd, Somaieh, Mahfoozi, Lida, Mahmoodiyeh, Behnam, Mansour-Ghanaei, Fariborz, Mansouri, Feizollah, Mesgarpour, Bita, Mesri, Mehdi, Mikaeili, Haleh, Miladi, Ronak, Moghadami, Mohsen, Mohamadi, Payam, Mohraz, Minoo, Mohseni Afshar, Zeinab, Moogahi, Sasan, Mousavi Anari, Seyed Alireza, Mozaffar, Seyyed Hassan, Mozdourian, Mahnaz, Najafipour, Reza, Najari, Hamidreza, Nazemiyeh, Masoud, Norouzi, Alireza, Pourkazemi, Aydin, Poustchi, Hossein, Saberhosseini, Seyedeh Naeimeh, Saberi, Marzieh, Saber-Moghaddam, Niloufar, 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Eleonora, d'Arminio Monforte, Antonella, de Gaetano Donati, Katleen, De Nardo, Pasquale, De Rosa, Francesco Giuseppe, Degioanni, Maria, Della Siega, Paola, Di Bella, Stefano, Drera, Bruno, Focà, Emanuele, Fornabaio, Chiara, Galli, Massimo, Giacomazzi, Donatella, Gori, Andrea, Gustinetti, Giulia, Iannuzzi, Francesca, Kertusha, Blerta, Lamonica, Silvia, Lichtner, Miriam, Lupia, Tommaso, Luzzati, Roberto, Macera, Margherita, Menatti, Elisabetta, Merelli, Maria, Merlini, Esther, Monari, Caterina, Pan, Angelo, Pecori, Davide, Pezzani, Diletta, Riccardi, Niccolò, Rodari, Paola, Roldan, Eugenia, Rovere, Pierangelo, Rusconi, Stefano, Scabini, Silvia, Tascini, Carlo, Viale, Pierluigi, Vincenzi, Marcello, Zuccalà, Paola, Zucchi, Patrizia, Al-Roomi, Moudhi, Al-Sabah, Salman, Schrapp, Kelly, Hassoun, Mahmoud, Matar, Madonna, Dbouni, Oussaima, Yared, Nadine, Saliba, Michele, Farra, Anna, Riachi, Moussa, Zablockiene, Birute, Reuter, Jean, Staub, Therese, Ab Wahab, Suhaila, Chew, Chun Keat, Chua, 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Faisal, Walayat, Usman, Agurto-Lescano, Erika Cecilia, Alcantara-Díaz, Andrés Martín, Alva-Correa, Ana María, Alvarado-Moreno, José Gustavo, Ángeles-Padilla, Bethsabé, Arbañil-Huamàn, Hugo César, Ávila-Reyes, Pool Christopher, Azañero-Haro, Johan Alexander, Barreto-Rocchetti, Luis Guillermo, Benitez-Peche, Jorge Marko A., Bernal-Màlaga, Karla Hortencia, Cabrera-Portillo, Liliana Norma, Carazas-Chavarry, Reynaldo Javier, Càrcamo, Paloma Mariana, Casimiro-Porras, Indira Catalina, Castillo-Espinoza, Jhuliana, Chacaltana-Huarcaya, Jesús Norberto, Cornejo-Valdivia, Carla Raquel, Cruz-Chereque, Augusto, Del-Aguila-Torres, Keith Cayetano Marcelino, Díaz-Chipana, Erika, Flores-Valdez, Neil, Franco-Vàsquez, Rosanna Andrea, Gallegos-López, Roxana Consuelo, Gastiaburú-Rodriguez, Dauma Yesenia, Gianella-Malca, Gonzalo Ernesto, Gomero-Lopez, Andrés Alonso, Hercilla-Vàsquez, Luis Enrique, Hueda-Zavaleta, Miguel Ángel, Ibarcena-Llerena, Claudia Vanessa, Iberico-Barrera, Carlos Alberto, 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Terrazas-Obregón, Carmen Sara, Terrones-Levano, Victor Francisco, Ticona-Huaroto, Cesar Eduardo, Torres-Ninapayta, Walter, Torres-Ruiz, Oscar Martin, Ugarte-Mercado, Dario, Vargas-Anahua, Orlando José, Vàsquez-Becerra, Ruben Dario, Vàsquez-Cerro, José Gabriel, Villegas-Chiroque, Miguel, Williams, Anna Larson, Yauri-Lazo, Randi Mauricio, Abad, Cybele Lara, Andales-Bacolcol, Silverose Ann, Arcegono, Marlon, Arches, Jamie, Astudillo, Mary Grace, Aventura, Emily, Awing, Arlyn, Bala, Mishelle Vonnabie, Bello, Jia An, Blanco, Peter, Benedicto, Jubert, Buno, Susana, Cabrera, Justine, Cajulao, Thea Pamela, Caoili, Janice, Casiple-Amsua, Lina, Catambing, Victor, Chin, Inofel, Chua, Ma. 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Published
2022
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40. Chagas Disease in Europe

Author

Marta Gonzalez-Sanz, Clara Crespillo-Andújar, Sandra Chamorro-Tojeiro, Begoña Monge-Maillo, Jose A. Perez-Molina, and Francesca F. Norman

Subjects
Trypanosoma cruzi, vertical transmission, migration, neglected tropical disease, Medicine
Abstract

Chagas disease is currently present in many non-endemic countries and remains a neglected tropical disease globally. A review of the literature identified significant gaps and scarcity of updated information from European countries, with most studies reporting data from Spain and Italy. The index of underdiagnosis may be as high as 70%, affecting mainly females of child-bearing age. Standardized screening of fertile, non-pregnant, women from endemic countries and subsequent treatment is considered an essential strategy to control transmission and prevent new cases, yet no uniform legislation for screening risk groups exists. There is heterogeneity in Europe in terms of preventive strategies to avoid transfusion-related transmission of Chagas disease, not necessarily in line with the European directives, with some countries conducting systematic screening for T. cruzi infection in blood donors, whilst others rely on pre-transfusion questionnaires. The growing burden of the infection in resource-rich areas may provide an opportunity for progress in certain aspects of control and prevention. Options for improving screening strategies, management and linkage to care are reviewed.

Published
2023
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43. Hallazgos en resonancia cardiaca post COVID-19 en pacientes sin elevación de troponinas

Author

Adrián Carlessi, Leonel Perello, Cristian Pantaley, Armando Borsini, Lucía Rossi, Florencia Giménez, Julián Leonardi, Ariel Ballina, Martin Maillo, Paula Di-Rienzo, Paula Gonzalo, Martín González-Vara, Luciana Vegetti, Sebastián Wustten, Lucas Costa, Diego Vergara, and Cristian Froullet

Subjects
COVID-19. Resonancia cardiaca magnética. Realce tardío de gadolinio. Troponinas., Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Antecedentes: La enfermedad por coronavirus 2019 (COVID-19) afecta al sistema cardiovascular, ya sea mediante la agresión directa viral o indirectamente por medio de la inflamación sistémica y afectación multiorgánica. Las troponinas son ampliamente utilizadas para determinar lesión cardiaca. La finalidad de este estudio es evaluar la prevalencia de afectación cardiaca (ACARD) en una población recuperada de COVID-19, derivada a resonancia magnética cardiaca (RMC), sin elevación de troponinas al momento del estudio. Métodos: Ciento cincuenta y seis pacientes que se recuperaron de COVID-19 y que no presentaron elevación de troponinas fueron derivados a RMC. Se consideró ACARD a la presencia de: realce tardío de gadolinio (RTG), edema, miocarditis, pericarditis, deterioro de la función sistólica del ventrículo izquierdo (DFSVI) y/o depresión de la función sistólica del ventrículo derecho (DFSVD). Resultados: La prevalencia de ACARD fue del 28.8%, siendo más frecuente en hombres (p = 0.002), en pacientes que requirieron hospitalización (p = 0.04) y en aquellos que cursaron cuadro no leve de infección (p = 0.007). La DFSVD (17.9%) y la DFSVI (13.4%) fueron las hallazgos más frecuentes. La frecuencia de miocarditis fue del 0.6%. El RTG se manifestó en el 7.1% de los pacientes y se relacionó con menor fracción de eyección del ventrículo izquierdo (FEVI) (p = 0.0001) y derecho (FEVD) (p = 0.04). Conclusión: La prevalencia de ACARD fue del 28.8%. Esta es más frecuente en hombres, en pacientes que requirieron internación y que cursaron cuadros de infección no leve. La miocarditis presentó una prevalencia muy baja. Los pacientes que presentaron RTG tuvieron menor FEVI y FSVD.

Published
2023
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44. scAEGAN: Unification of single-cell genomics data by adversarial learning of latent space correspondences.

Author

Sumeer Ahmad Khan, Robert Lehmann, Xabier Martinez-de-Morentin, Alberto Maillo, Vincenzo Lagani, Narsis A Kiani, David Gomez-Cabrero, and Jesper Tegner

Subjects
Medicine, Science
Abstract

Recent progress in Single-Cell Genomics has produced different library protocols and techniques for molecular profiling. We formulate a unifying, data-driven, integrative, and predictive methodology for different libraries, samples, and paired-unpaired data modalities. Our design of scAEGAN includes an autoencoder (AE) network integrated with adversarial learning by a cycleGAN (cGAN) network. The AE learns a low-dimensional embedding of each condition, whereas the cGAN learns a non-linear mapping between the AE representations. We evaluate scAEGAN using simulated data and real scRNA-seq datasets, different library preparations (Fluidigm C1, CelSeq, CelSeq2, SmartSeq), and several data modalities as paired scRNA-seq and scATAC-seq. The scAEGAN outperforms Seurat3 in library integration, is more robust against data sparsity, and beats Seurat 4 in integrating paired data from the same cell. Furthermore, in predicting one data modality from another, scAEGAN outperforms Babel. We conclude that scAEGAN surpasses current state-of-the-art methods and unifies integration and prediction challenges.

Published
2023
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45. La familia. Fundamento de la civilización

Author

de la Cigoña, Carmen Fernández, Maíllo, Carmen Sánchez, García, Elio Alfonso Gallego, Pacheco, Carmen Cortés, Sánchez, Ana Sánchez-Sierra, Tártalo, María Teresa Díaz, Giordano, Marco, García, Jesús F. Cogollos, Fraga, Ondina Vélez, Oporto-Alonso, Marta, De Santiago Mateos, Miguel Ángel, Escobal, Pedro Luis Lainez, De La Cigoña, Carmen Fernández, de la Cigoña, Carmen Fernández, Maíllo, Carmen Sánchez, García, Elio Alfonso Gallego, Pacheco, Carmen Cortés, Sánchez, Ana Sánchez-Sierra, Tártalo, María Teresa Díaz, Giordano, Marco, García, Jesús F. Cogollos, Fraga, Ondina Vélez, Oporto-Alonso, Marta, De Santiago Mateos, Miguel Ángel, Escobal, Pedro Luis Lainez, and De La Cigoña, Carmen Fernández

Published
2023

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