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АКТУАЛЬНОСТЬ: Опухоли хиазмально-селлярной области (ХСО) составляют 20–25 % всех первичных внутричерепных новообразований, из них аденомы гипофиза — до 20 % населения планеты. В настоящее время удаление этих новообразований выполняется с использованием эндоскопических транссфеноидальных хирургических доступов. ЦЕЛЬ ИССЛЕДОВАНИЯ: Анализ и обобщение результатов публикаций, касающихся периоперационных особенностей ведения пациентов с опухолью ХСО. МАТЕРИАЛЫ И МЕТОДЫ: Поиск и отбор публикаций осуществляли в библиографических базах данных PubMed, Web of Science, Scopus. Для изучения подхода к периоперационному ведению пациентов с опухолями ХСО проанализированы работы, опубликованные с 2013 по 2023 г. Ключевые слова для поиска: «pituitary surgery», «anesthesia». На основании анализа актуальных проблем при планировании анестезиологического обеспечения пациентов с опухолями ХСО поиск расширен дополнительными ключевыми словами: «pituitary tumor», «perioperative complications», «endocrine disorders», «difficult airway», «acromegaly», «cardiologic complications, acromegaly», «peripherical neuropathy, acromegaly», «trigemino-cardiac reflex», дополнительно проанализировано 206 публикаций и обобщены основные ключевые моменты при планировании анестезии. Всего после уточнения параметров поиска в исследование вошло 230 публикаций, из которых в последующем исключены 161. В общей сложности отобрано 69 исследований. РЕЗУЛЬТАТЫ: Основными особенностями пациентов с опухолями ХСО являются: водно-электролитные нарушения, сердечно-сосудистая патология, обеспечение проходимости верхних дыхательных путей. Это обусловливает мультдисциплинарный подход при подготовке к операции. Необходимо учесть это при планировании анестезиологического обеспечения и ведения раннего послеоперационного периода. Кроме этого, при эндоскопическом трансназально-трансфеноидальном доступе может возникнуть ряд осложнений: повреждение гипотоламической области и крупных сосудов, в послеоперационном периоде — дыхательные нарушения, водно-электролитный дисбаланс, гормональная недостаточность. ВЫВОДЫ: При подготовке пациента с образованием ХСО к операции необходимо проявлять дополнительную настороженность. Периоперационное ведение пациента с опухолью ХСО требует командного подхода с участием нейрохирургов, неврологов, окулистов, эндокринологов, кардиологов, анестезиологов-реаниматологов.

Mortality and disability rates in spontaneous intracranial hemorrhages remain high despite medical advances. In recent decades, much attention has been paid to neuroinflammation as a typical response to brain damage. Inflammation plays an important role in the acute and chronic phases of the disease. The relationship between plasma and cerebrospinal fluid cytokines, as well as the factors affecting their ratios, is currently not completely clear.The objective was to study the inflammatory response to spontaneous intracranial hemorrhage.Subjects and Methods. 59 patients aged 18 to 72 years (48 ± 6) were enrolled in the study. Patients were admitted to the intensive care unit after an episode of spontaneous intracranial hemorrhage. The levels of interleukins in blood plasma were studied: 6, 8, 10, TNF-α, C-reactive protein,blood leukocytes, and procalcitonin (by a semi-quantitative method). In the cerebrospinal fluid, the following parameters were evaluated: cytosis, protein, glucose, lactate, cytokines (6, 8, 10, TNF-α). Blood samples were collected on days 1, 2, 3, 5, 7, 9, 14, 21, 28, 35, and 45.Results. Systemic inflammatory response developed in all patients from the first day of acute brain injury. The most significant response was formed by glial brain cells which was confirmed by high levels of cytokines in the cerebrospinal fluid, hundreds and thousands of times higher than blood levels of cytokines.Conclusion. Levels of pro-inflammatory cytokines are predictors of an unfavorable outcome.

Purpose: to study the clinical signs and effectiveness of laboratory diagnostics of fungal corneal ulcer complicated by endophthalmitis aimed at treatment tactics optimization.Materials and methods. 15 patients aged 20–55 with severe monocular fungal ulcer complicated by endophthalmitis were examined by microscopy and culture of corneal scraping on Sabouraud Agar; microscopy and culture of intraocular fluid and corneal fragments, obtained during the surgical treatment. Corneal scrapings from the corneal ulcer and corneal fragments removed during keratoplasty were tested in polymerase chain reaction (PCR) for the presence of deoxyribonucleic acid (DNA) of Candida albicans and total Fungi DNA.Results. Before treatment start, 2.5 hours after the biomaterial was taken, PCR revealed Fungi DNA in all 15 cases. Symptoms of the severe fungal corneal ulcer complicated by endophthalmitis and caused by Aspergillus spp have been identified and described. Conservative therapy and total penetrating keratoplasty (PKP) helped retain the eye in 13 out of 15 patients (86.7 %) and partially restore the visual functions.Conclusion. Rapid laboratory diagnosis of ophthalmomycosis using PCR offers an advantage over the culturing technique: the results are ready within 2.5 hours instead of 10-14 days (culture method); it is highly sensitive and allows identifying the fungi not only in the tissue of the removed cornea, but also in the сorneal scrapings. The effective treatment tactics of fungal corneal ulcer complicated by endophthalmitis combining PKP with pre-operative and long-term postoperative antifungal therapy was proposed.

Purpose: to evaluate the results of spontaneous non-penetrating keratoprosthesis with a Fedorov — Zuev prosthesis in a patient with severe chemical burns in both eyes. Material and methods.Patient K., 38, who had sustained a severe burn injury in the past and numerous reconstructive plastic operations on both eyes (amniotic tissue implantation, allolymbal transplantation, layer-by-layer and penetrative keratoplasty, cataract extraction with IOL implantation, total auto-conjunctival corneal plastic surgery) with no functional effect, was subjected to a multi-stage keratoprosthesis of the left eye according to the method practiced by the Helmholtz National Medical Research Center of Eye Diseases. Results.After one of the stages (implantation of the haptic part of the keratoprosthesis with a temporary cylindrical plug), an aseptic necrosis of the tissue above the cylinder occurred. As a result, an unexpected functional effect was revealed: visual acuity of the operated eye 0.02 sph -20.0 D = 0.2. During a dynamic follow-up that lasts 2.5 years, visual acuity remains stable, and the corneallayers behind the cylinder retain transparency. During this time, all stages of keratoprosthesis were performed on the fellow eye with a functional result of 1.0. Conclusion. The long-term result of spontaneous non-penetrating keratoprosthesis indicates the need to study the prospects and develop a method of non-penetrating keratoprosthesis with a Fedorov — Zuyev prosthesis.

Purpose: to evaluate the effectiveness of platelet-rich plasma (PRP) lysate in patients with corneal erosion or posttraumatic scarring of eyelid tissues.Material and methods. The study involved 30 patients aged 22 to 82 (51.5 ± 19.1 years): 10 with persistent corneal erosions, who were treated in 2 stages (2 weeks of standard keratoprotective therapy, then treatment supplemented with instillations of PRP lysate) and 20 patients with post-traumatic scarring of eyelid tissues, who were divided into a clinical group and a comparison group. PRP lysate was produced in the cell transplantation and immunotyping laboratory of N.V. Sklifosovsky Research Institute for Emergency Medicine.Results. In group 1, already on the 3rd day of PRP lysate use, a positive dynamic of the cornea was observed: all patients had fewer complaints of pain, photophobia, and lacrimation. Corneal biomicroscopy, performed daily over the entire epithelization period, revealed a decrease in hyperemia of the tarsal and bulbar conjunctiva and corneal edema, which indicated a weakened inflammatory response. On average, the area of the cornea at the start of traditional therapy was 21.6 [19.6; 30.65] mm2. After two weeks of treatment, at the time of adding PRP lysate, the average area of erosion fell to 15.7 [12; 18.9] mm2, after a week of treatment with lysate, it dropped to an average of 2.35 [0.4; 4.3] mm2. On day 14, all patients revealed complete epithelialization of the corneal defect. In patients with post-traumatic eyelid tissue scars, after a 3-month-long use of PRP lysate (study group), an improvement was noted in the cosmetic and functional state of the eyelids, on average by 4 points (Me = 12 [10; 12] points before and 8.5 [8; 9] points after treatment (on the Manchester scar assessment scale), in contrast to the patients who received no anti-scar therapy (comparison group), as the latter showed a deterioration in the condition of eyelid scars by 1–2 points (Me = 11 [10.25; 11.75] points at the beginning and 12 [11; 12] points at the end of the observation period). The acoustic density of scar tissue in the study group approached the normal values, in contrast to the comparison group, in which scar tissue appeared to be hypoechoic.Conclusion. Using PRP lysate aimed at improving the repair and regeneration processes in patients with corneal erosion or post-traumatic scarring of eyelid tissues is promising and requires further clinical study.

The purpose. Using clinical observation, to study the feasibility of applying a coagulant and to assess its efficacy in the treatment of patients with post-burn erosion of the cornea.Material and methods. The treatment was carried out in the Department of Trauma and Reconstructive Surgery, the Helmholtz Moscow Research Institute of Eye Diseases, Russia. Based on clinical test results, the patient, was diagnosed with post-burn persistent erosion of the cornea with sub-total cornea conjunctivization and: limbal stem cell deficiency (LSCD) in the right eye. The keratoprotective therapy conducted for several months turned ineffective. In order to activate the cornea regeneration process, the erosion site was covered with autologous thrombofibrin clot that had been obtained from the stabilized blood. Following a two-stage centrifugation of patient's stabilized blood, the plasma with the platelets were collected into a round-bottomed test-tube; and the chloride calcium activator was added. The clot was formed in the thermostat at a temperature of 37 С. The patient was given a local anesthesia, and the thrombofibrin clot was placed on the cornea surface and covered with an amniotic membrane. The membrane was fixed with a circular stitch along the limbus of the cornea.Result. The patient was followed-up and showed positive changes over time in the form of a diminished erosion area at day 5 and a complete corneal epithelialization at day 14.Summary. Our methodaimed at enhancing the reparative and regenerative processes in the cornea, reducing swelling, accelerating epithelialization, expanding transparency, and improving the optic characteristics thanks to less intensive opacity formation showed a high efficacy.

The paper is focused on combined burn injuries of the eye, face and other body parts in acute care patients treated in non-ophthalmic hospital departments. Purpose: to develop patterns of actions by ophthalmologists and burn doctors at various stages of multiple burn injuries in patients treated in burn units. Materials and methods. 158 burn patients were given full clinical and instrumental examination. Group 1 included 95 patients hospitalized in the department of eye traumatology and reconstructive surgery after being treated in burn units elsewhere, while group 2 consisted of 63 patients examined and treated simultaneously by ophthalmologists and burn doctors from the start of admission to burn units. Results. The patients in Group 1 developed serious ophthalmic complications, ranging from ulceration or perforation of outer eye coats, swollen cataracts, hypopyon, cicatricial eyelid deformation, lagophthalmos etc. to eye apple atrophy, all caused by the absence of eye surgery assistance at early stages of burn treatment. Conclusion. The proposed patterns and range of surgical assistance including that given in the early stages of treatment, prevented the development of severe complications to the eye and the annexa, reduced the rehabilitation period and improved the functional prognosis of combined burn eye injuries. For citation: Chentsova E.V., Makarov P.V., Verigo Е.N., Petrova A.O., Smirnov S.V. Patterns of treatment of combined burn eye injuries in patients hospitalized in burn units. Russian ophthalmological journal. 2018; 11 (3): 37-42 (In Russian). doi: 10.21516/2072-0076-2018-11-3-37-42

The scope of uses of automated document recognition has extended and as a result, recognition techniques that do not require specialized equipment have become more relevant. Among such techniques, document recognition using mobile devices is of interest. However, it is not always possible to ensure controlled capturing conditions and, consequentially, high quality of input images. Unlike specialized scanners, mobile cameras allow using a video stream as an input, thus obtaining several images of the recognized object, captured with various characteristics. In this case, a problem of combining the information from multiple input frames arises. In this paper, we propose a weighing model for the process of combining the per-frame recognition results, two approaches to the weighted combination of the text recognition results, and two weighing criteria. The effectiveness of the proposed approaches is tested using datasets of identity documents captured with a mobile device camera in different conditions, including perspective distortion of the document image and low lighting conditions. The experimental results show that the weighting combination can improve the text recognition result quality in the video stream, and the per-character weighting method with input image focus estimation as a base criterion allows one to achieve the best results on the datasets analyzed.

Abstract The two-detector design of the NOvA neutrino oscillation experiment, in which two functionally identical detectors are exposed to an intense neutrino beam, aids in canceling leading order effects of cross-section uncertainties. However, limited knowledge of neutrino interaction cross sections still gives rise to some of the largest systematic uncertainties in current oscillation measurements. We show contemporary models of neutrino interactions to be discrepant with data from NOvA, consistent with discrepancies seen in other experiments. Adjustments to neutrino interaction models in GENIE are presented, creating an effective model that improves agreement with our data. We also describe systematic uncertainties on these models, including uncertainties on multi-nucleon interactions from a newly developed procedure using NOvA near detector data.

In this article the importance of the spouse's consent to engage in civil law deals is considered. The specifics of obtaining consent of the spouse for the deal under the disposal of jointly acquired property are analyzed. In addition, proposals have been made to improve the legislation in the sphere of obtaining the consent of the spouse to dispose of movable property, as well as to dispose of the property by the spouse whose marriage is terminated by the time the transaction is concluded.

Crustaceans of the Azov–Black Sea basin, in particular, the shrimp Palaemon adspersus, are a type of raw material easily available in the domestic market, because the large volumes of its industrial production in the Azov–Black Sea basin make it inexpensive and abundant. That is why we have suggested innovative products with the addition of Palaemon adspersus meat: dumplings (pelmeni) and fish fingers. We selected the following main recipe components of these dumplings: Palaemon adspersus meat, Azov–Black Sea goby meat, unleavened dough, and those for fish fingers: Palaemon adspersus meat, Azov–Black Sea goby meat, egg powder. To enhance the taste and aroma, Svanetian salt was added to the minced meat in the model compositions of the products developed. To substantiate the rational content of the recipe components in the model compositions of products with Palaemon adspersus meat added, the method of qualimetric analysis of the sensory parameters was used. According to the results of qualimetric evaluation, it has been found that for dumplings, the best ratio of Palaemon adspersus meat, Azov–Black Sea goby meat, and unleavened dough is 1:2.7:3, and for fish fingers, the most practical ratio of Palaemon adspersus meat, Azov–Black Sea goby meat, and egg powder is 2.5:6.5:1. The obtained results of qualimetric analysis of the model compositions have been confirmed by mathematical calculations using multiple linear regression with initial determination of criterial factors of influence. According to the mathematical calculations performed, the highest value of the parameter (y1 = 0.93) has been obtained for the model composition of dumplings with Palaemon adspersus meat added with the ratio of the recipe components 1:2.7:3. For fish fingers, the highest value of the parameter (y4 = 0.8) has been determined for the model composition where the ratio of the recipe components was 2.5:6.5:1. These calculations confirm the objectivity, efficiency, and practicality of the chosen method of qualimetric analysis of the model compositions under study

The issue of establishing the boundaries of water protection and coastal stripes in Ukraine were examined in the article. The purpose of the study is to present the practical results of the formation the boundary delimiter of coastal protection stripes, based on scientific and methodological approaches to the development of land management projects for the establishment of coastal protection stripes and modern technologies in the area of geographic information system. Theoretical principles of establishing the boundaries of water protective zones and coastal protective stripes on water resources are analyzed. Regulatory basic documents on the subject of use in the establishment of water protection zones and coastal protection stripes have been explored. It is noted that the size of water protective zones and coastal protective stripes can be set in accordance with the provisions of the Land Code of Ukraine, and according to the especial projects in land management. It is suggested the procedure for establishing coastal and water protective zones is based on determining the hydrographic characteristics of water sites and morphological parameters of coastal areas using remote sensing data and geoinformation system and includes six steps: 1. Determination of morphometric parameters of water sites. 2. Obtaining relief data and its application 3.Determining the steepness of the slopes. 4. Construction of catchment areas and determination of surface effluent directions. 5. Creation of a buffer zone around water sites (construction of a protective stripe and a water protective zone). 6. Combining layers of informative maps for the final definition of boundaries. The use of the methodology is presented on a specific example, namely the pond in the village Gremyache, Rivne region. Methodology will provide a technical background for establishing and decision-making on the size of water protective zones and coastal protection stripes around water objects. One more aspect of the problem, solved by the methodology proposed in the article, involves informative supporting of decisions in a sphere of controlling water fund lands at the regional level as part of the planning measures for sustainable regions development and protection of water objects. Keywords: water protective zone, coastal protection belt, land management project, Earth remote sensing data of the Earth and geographic information system data, boundaries of the water protective zone and coastal protective stripe

The analysis of the current legislation regulating the procedure for the entry and exit of minors outside the Russian Federation has been carried out, the features of obtaining consent for the departure of a minor outside the Russian Federation have been noted. The necessity of notarization of such consent has been investigated, judicial decisions on this issue have been considered, and the legal norms governing the form of withdrawal of consent to a minor’s departure have been examined. The author has formulated proposals to improve the current legislation governing the entry and exit of minors outside the Russian Federation, including legislatively stating the obligation of the person who has withdrawn consent to leave the minor, to inform the interested person and the minor himself about such actions within a reasonable time.

The quality of fruit of garden strawberries grown on technogenically contaminated soils has been assessed. The highest level of copper and zinc in the fruit was recorded after broadcasting the recommended quantity of the fertiliser N90P60K30. Introduction of the sorbent ameliorant GREENODIN GRAY reduced the content of copper and zinc in the strawberries by 39 and 59% respectively. Researching the early-ripening strawberry cultivars Olviya and Rozana Kyivska has revealed varietal differences in the fruit’s trace element composition. Thus, it can be considered that selection of the proper cultivar is another effective method of obtaining environmentally safe products. Both strawberry cultivars under study were characterised by intense translocation of Cu and Zn into fruit. However, the Rozana Kyivska fruit contained 3 times more copper than the cultivar Olviya did. The zinc level, too, was higher in the Rozana Kyivska fruit (by 1.5 times). When introducing the recommended quantity of the fertiliser N90P60K30, the following criteria for the potential storability and transportability of the Olviya berries were recorded: resistance to phytopathogens, dense consistency of a berry, and the dry matter content 10.08%. As a result, the Olviya berries had the longest shelf life – 7 days, when stored in cooling chambers at 0.5°С and relative air humidity 90%. The sugar-acid index in these samples had the maximum value 6.9%, but the amount of vitamin C was at a minimum. This research has become the basis for practical application of a technology of growing strawberries of the cultivar Olviya. The technology involves broadcasting the fertiliser N90P60K30 together with the sorbent ameliorant GREENODIN GRAY (500 kg/ha) during the primary tillage, and introduction of N45P30K15 with irrigation water. The resulting Olviya berries are resistant to diseases and phytopathogenic damage during storage, have high nutritional value, and are less likely to accumulate ecotoxicants. The yield of berries in the first year of using the plantation was 6,200–6,500kg/ha. The content of nitrates and heavy metals in the berries did not exceed the maximum permissible concentration.

In this article the importance of the spouse's consent to engage in civil law deals is considered. The specifics of obtaining consent of the spouse for the deal under the disposal of jointly acquired property are analyzed. In addition, proposals have been made to improve the legislation in the sphere of obtaining the consent of the spouse to dispose of movable property, as well as to dispose of the property by the spouse whose marriage is terminated by the time the transaction is concluded.

9 Russian Vitis vinifera grape varieties and the European variety Muscat Hamburg were sequenced and genotyped using 527 SNPs (single nucleotide polymorphisms) with high minor allele frequency for the first time. The data were coupled with previously identified genotypes of 783 varieties and subjected to parentage and population analysis. As a result, contrary to the historical and ampelographic data published in many sources from 1800 to 2012, only two of the nine Russian varieties (Pukhlyakovskiy Belyi and Sibirkovyi) were related to foreign ones and were obviously imported from Europe to the Russian Empire. The remaining seven varieties, led by Krasnostop Zolotovskiy, are not directly related either in the Caucasus or in Europe, they form separate clusters on the genetic distance-based dendrogram and the world parentage network of V. vinifera. The resulting pedigree of Muscat Hamburg and its descendants is in accordance with SSR-based (simple sequence repeats) studies and the described pedigree of this variety which confirms the use of the reduced SNP set for further studies.

The article deals with foreign legislation concerning assistance given to intoxicated persons in a public place. The article is devoted to a detailed analysis of the foreign law enforcement officers’ activities when discovering intoxicated persons in public places, and describes the procedure of transfer and treatment of such persons in specialized institutions.

The article deals with foreign legislation regarding alcohol-intoxicated persons seen in public places. The author analyzed the interpretation of the concepts of "intoxicated condition", "public place" under the laws of foreign countries. The emphasis is given to the problems of bringing intoxicated persons seen in public places to administrative and criminal liability. Much attention is paid to the US laws containing rules of responsibility for public intoxication.

The influenza epidemic in 2015-2016 in Russia is characterized by a sharp increase of influenza cases (beginning from the second week of 2016) with increased fatalities. Influenza was confirmed in 20 fatal cases registered among children (0-10 years), in 5 cases among pregnant women, and in 173 cases among elderly people (60 years and older). Two hundred and ninety nine people died from influenza were patients with some chronic problems. The overwhelming majority among the deceased (more than 98%) were not vaccinated against influenza. We isolated 109 influenza A(H1N1)pdm09 and one A(H3N2) virus strains from 501 autopsy material samples. The antigenic features of the strains were similar to the vaccine strains. A phylogenic analysis of hemagglutinin revealed that influenza A(H1N1)pdm09 virus strains belonged to 6B genetic group that had two main dominant subgroups during the 2015-2016 season. In Russia strains of the first group predominated. We registered an increased proportion of strains with D222G mutation in receptor-binding site. A herd immunity analysis carried out immediately prior to the epidemic showed that 34.4% blood sera samples collected in different regions of Russia were positive to A/California/07/09(H1N1)pdm09. We came to a conclusion that public awareness enhancement is necessary to reduce unreasonable refusals of vaccination.