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Atopic dermatitis (AD), the most frequent chronic skin disease of early childhood, is associated with impaired barrier function. The recognition and removal of factors recognized as potential irritants may improve the symptoms of DA and reduce flares. Many types of fabrics could exacerbate AD, but others may help to control this condition. Synthetic fabrics and wool tend to produce irritant reaction and itching. Cotton is frequently recommended in AD patients, however its structure contains short fibers which expand and contract when the fabric is wet causing a rubbing that can irritate the atopic skin. Also, cotton is sensitive to the colonization of bacteria and fungi, making over-infection easier. Finally, the dyes used for dying of cotton clothes can complicate AD promoting contact sensitization. The type of silk fabric generally used for clothing is not particularly useful for the treatment and care of children with AD because it reduces transpiration; furthermore, some people may be allergic to the sericin, a protein in the silk . Several studies reported in the literature, have suggested that Microair Dermasilk®, a particular type of silk without sericin and permanently bonded to a anti-microbial agent (AEGIS AEM 5772/5) is well tolerated and has beneficial effects on atopic skin. The effectiveness of this tissue on eczema has been undoubtedly prove, while it is doubtful its ability to reduce the number of colonies of Staphylococcus aureus which often colonize eczema causing a worsening of the disease. In fact AEGIS AEM 5772/5 has shown antimicrobial properties in vitro while in vivo there are conflicting opinions. The last fiber approved by the “Federal Trade Commission” is Lyocell, a cellulosic fiber belonging to the generic” man-made fibers”: Lyocell fiber is currently available as a soft tissue able to improve the comfort of the patient with AD.