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1. Contents, Vol. 36, 1991

Author

M. Zachmann, C. Jung-Hoffmann, Mikihiko Kudo, Jean-Marie Cottet-Emard, Carlos Dieguez, D. Gambarana, R. Rappaport, T. Ohzeki, Kiyohiko Kato, A. D’Alberton, Kenji Ohyama, Jens Christoffersen, Felipe F. Casanueva, M. Cisternino, Rosa Bussi, R. Keret, G. Giorgiani, Makoto Nakazono, Andrea Giustina, Jose I. Vidal, Fernando Cordido, F. Locatelli, A. Valtorta, F. Severi, C. Gübelin-De Campo, A. Silbergeld, M. Bozzola, Aino Torsson, Hajime Watanobe, M. Ballabio, Meta Damkjœr Nielsen, Masanori Ohta, M. Fitzner, Z. Laron, René Mornex, Masatoshi Fujimoto, Merete Jørgensen, M. Nissim, M. Lapidot, D. Bochicchio, Kazuo Takebe, B. Manella, Rumiko Aoki, Grazia Buffoli, M. Wasserman, I. Ashkenazi, Katharina M. Main, Ieuan A. Hughes, G. Faglia, Knud E. Petersen, Yoshiko Nakagomi, R. Orefice, G. Giorda, Remo Pagliari, William B. Wehrenberg, B. Schindel, Jørn Müller, Niels E. Skakkebæk, H. Kuhl, A.G. Harros, Malou Philips, Niels E. Skakkebœk, Liliane Peyrin, A. Moretta, and Toshitsugu Yamori

Subjects
Endocrinology, Endocrinology, Diabetes and Metabolism
Published
1991
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2. Effect of octreotide on 24-hour growth hormone and prolactin secretory patterns in acromegalics

Author

Zvi Laron, Ruth Keret, Aviva Silbergeld, B. Schindel, A.G. Harros, M. Lapidot, I. Ashkenazi, and M. Wasserman

Subjects
Adult, Male, endocrine system, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Octreotide, Growth hormone, Endocrinology, Internal medicine, Acromegaly, Medicine, Humans, Circadian rhythm, Aged, Chemotherapy, business.industry, Middle Aged, medicine.disease, Prolactin, Circadian Rhythm, Somatostatin, Growth Hormone, Female, business, Somatostatin analog, hormones, hormone substitutes, and hormone antagonists, medicine.drug
Abstract

Four adult patients with active acromegaly underwent studies of their 24-hour secretory pattern of hGH and Prl prior to and at the end of 3 months of treatment with the octreotide (somatostatin analog SMS 201-995) 100 micrograms s.c. every 8 h. Blood was withdrawn at 30-min intervals with the aid of a constant withdrawal pump. The best fit cosinor method was used to define the following rhythm parameters: mesor, amplitude, acrophase and periodicity. Prior to treatment, hGH secretion was increased in all patients. The mean 24-hour ranged from 9-47 ng/ml with amplitude 5.2-23 and observed maximal pulse 41-95 ng/ml. Computed rhythms were circadian in 3 patients and ultradian in 1; in 2 patients the acrophases were shifted to daytime. hPrl secretion was altered in 3 of the patients. Two had elevated mean 24-hour of 17.7 and 22.2 ng/ml, while computed rhythms showed semicircadian periodicity in 1 of them and circadian periodicity with a shift of acrophase to daytime in the other. The third patient who had normal hPrl levels, showed ultradian 8-hour periodicity. At the end of treatment there was a marked reduction in hGH secretion in 1 patient and a lesser reduction in the other 3. The rhythm was influenced by the masking effect of the drug, to yield an 8-hour period with acrophases related to injection clock time having equal amplitudes.(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1991

3. Subject Index, Vol. 36, 1991

Author

A. Silbergeld, Hajime Watanobe, Masatoshi Fujimoto, M. Lapidot, A. Moretta, Toshitsugu Yamori, Fernando Cordido, Makoto Nakazono, M. Fitzner, F. Locatelli, Knud E. Petersen, Mikihiko Kudo, Jørn Müller, Carlos Dieguez, I. Ashkenazi, D. Gambarana, Yoshiko Nakagomi, R. Rappaport, T. Ohzeki, H. Kuhl, L. Peyrin, Katharina M. Main, C. Jung-Hoffmann, Niels E. Skakkebæk, Meta Damkjœr Nielsen, A. Valtorta, A.G. Harros, Jose I. Vidal, M. Nissim, D. Bochicchio, William B. Wehrenberg, A. D’Alberton, Felipe F. Casanueva, M. Cisternino, G. Giorgiani, Aino Torsson, Rosa Bussi, M. Zachmann, G. Faglia, Malou Philips, R. Orefice, M. Bozzola, G. Giorda, Remo Pagliari, Ieuan A. Hughes, M. Wasserman, Jean-Marie Cottet-Emard, Masanori Ohta, B. Manella, F. Severi, René Mornex, B. Schindel, Rumiko Aoki, Grazia Buffoli, Merete Jørgensen, C. Gübelin-De Campo, Kazuo Takebe, M. Ballabio, Z. Laron, R. Keret, Jens Christoffersen, Andrea Giustina, Kiyohiko Kato, Kenji Ohyama, and Niels E. Skakkebœk

Subjects
Endocrinology, Index (economics), Endocrinology, Diabetes and Metabolism, Statistics, Subject (documents), Mathematics
Published
1991
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