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3 results on '"A.J.M. Siepman"'

1. Translocation (12;22)(p13;q12) as sole karyotypic abnormality in a patient with nonlymphocytic leukemia

Author

A. Geurts van Kessel, A.J.M. Siepman, J. C. van Gaal, W. van de Klundert, F. Stellink, and H.R. Oosten

Subjects
Male, Cancer Research, Chromosomes, Human, Pair 22, Chromosomal translocation, Biology, Translocation, Genetic, hemic and lymphatic diseases, Genetics, medicine, Humans, Molecular Biology, In Situ Hybridization, Fluorescence, Chromosome 12, Southern blot, Chromosomes, Human, Pair 12, ABL, medicine.diagnostic_test, DNA, Neoplasm, Middle Aged, medicine.disease, Molecular biology, Leukemia, Myeloid, Acute, Leukemia, medicine.anatomical_structure, Immunology, Atypical chronic myeloid leukemia, Bone marrow, Fluorescence in situ hybridization
Abstract

Cytogenetic analysis of unstimulated bone marrow (BM) and peripheral blood (PB) cells of a patient with clinical features of atypical chronic myeloid leukemia (CML) showed t(12;22)(p13;q12) as the sole karyotypic abnormality. Subsequent fluorescence in situ hybridization (FISH) with abl- and bcr-specific cosmids as well as chromosome 12- and 22-specific DNA libraries and Southern blot analysis confirmed that in this patient t(12;22) does not constitute a cryptic Ph variant. Recently, a few very similar cases were reported by other investigators. The possible significance of this translocation as a new cytogenetic marker for nonlymphocytic leukemia is discussed.

Published
1994
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2. Ring chromosomes in a malignant mesenchymoma

Author

Anne Forus, René P. H. Veth, Irene M. Janssen, A.J.M. Siepman, A. Geurts van Kessel, Maciej Pruszczynski, R.F. Suijkerbuijk, Annet Simons, and P.P.F. Grandjean Perrenod Comtesse

Subjects
Cancer Research, medicine.medical_specialty, Ring chromosome, Chondrosarcoma, Aneuploidy, Biology, Malignant Mesenchymoma, Mesenchymoma, Development and application of "comparative genomic hybridization" techniques for the detection of specific chromosomal aberrations in solid tumors, Genetics, medicine, Humans, De rol van chromosoomafwijkingen en (anti-)oncogenen in humane tumoren, Ring Chromosomes, Tumor pathology, Molecular Biology, Small supernumerary marker chromosome, In Situ Hybridization, Muscle Neoplasms, medicine.diagnostic_test, Cytogenetics, Karyotype, Liposarcoma, Middle Aged, Chirurgische Oncologie, Tumor pathologie, medicine.disease, Surgical Oncology, Ontwikkeling en toepassing van "comparative genomic hybridization" technieken voor de detectie van specifieke chromosomale afwijkingen in solide tumoren, Karyotyping, Buttocks, Female, The role of chromosomal aberrations and (anti-)oncogenes in human tumours, Fluorescence in situ hybridization
Abstract

We report, for the first time, the cytogenetic and molecular genetic constitution of a human mesenchymoma. As in several other soft tissue sarcomas, supernumerary ring and rod-shaped marker chromosomes were observed next to an otherwise normal diploid karyotype. Comparative genomic in situ hybridization and whole chromosome painting experiments revealed that chromosome 1q21-q25 and 12q14-q15 sequences were amplified, and that these sequences resided on the supernumerary marker chromosomes. We assume that, in this malignant mesenchymoma, the observed chromosomal anomalies may be associated with its well differentiated liposarcomatous component.

Published
1999

3. Isochromosome (12p) and peritripoidy in a highly malignant extrarenal rhabdoid tumor

Author

A.J.M. Siepman, P.P.F. Grandjean Perrenod Comtesse, C.A. Hulsbergen-van de Kaa, U. J. G. M. van Haelst, Annet Simons, Th. Wobbes, R.F. Suijkerbuijk, F. Stellink, and A. Geurts van Kessel

Subjects
Male, Cytoplasm, Cancer Research, medicine.medical_specialty, Malignant rhabdoid tumor, Biopsy, Isochromosome, Aneuploidy, Soft Tissue Neoplasms, mogelijke oorzaken en gevolgen (sepsis en ontsteking) [Sepsis en niet-bacteriële gegeneraliseerde ontsteking], Biology, causes and effects (sepsis and inflammation) [Sepsis and non-bacterial generalized inflammation], Polyploidy, Development and application of "comparative genomic hybridization" techniques for the detection of specific chromosomal aberrations in solid tumors, Genetics, medicine, Humans, Tumor pathology, Molecular Biology, Rhabdoid Tumor, Chromosome 12, Chromosome Aberrations, Chromosomes, Human, Pair 12, medicine.diagnostic_test, Cytogenetics, Anatomy, Middle Aged, Tumor pathologie, medicine.disease, Transplantation, Forearm, Ontwikkeling en toepassing van "comparative genomic hybridization" technieken voor de detectie van specifieke chromosomale afwijkingen in solide tumoren, Karyotyping, Cancer research, Fluorescence in situ hybridization, Extrarenal Rhabdoid Tumor
Abstract

Here we present a new case of i(12p) and peritriploidy in an extrarenal rhabdoid tumor.

Published
1999
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