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Background: Cockle shell-derived calcium carbonate nanoparticles (CSCaCO3NP) are natural biogenic inorganic material that is used in drug delivery mainly as a bone-remodeling agent as well as a delivery agent for various therapeutics against bone diseases. Curcumin possesses a wide safety margin and yet puzzled with the problem of poor bioavailability due to insolubility. Propounding in vitro and in vivo studies on toxicity assessments of newly synthesized nanoparticles are ongoing to overcome some crucial challenges regarding their safety administration. Nanotoxicology has paved ways for concise test protocols to monitor sequential events with regards to possible toxicity of newly synthesized nanomaterials. The development of nanoparticle with no or less toxic effect has gained tremendous attention. Objective: This study aimed at evaluating the in vitro cytotoxic effect of curcumin-loaded cockle shell-derived calcium carbonate nanoparticles (Cur-CSCaCO3NP) and assessing its biocompatibility on normal cells using standard techniques of WST’s assay. Method: Standard techniques of WST’s assay was used for the evaluation of the biocompatibility and cytotoxicity. Result: The result showed that CSCaCO3NP and Cur-CSCaCO3NP possess minimal toxicity and high biocompatibility on normal cells even at a higher dose of 500 μg/ml and 40 μg/ml, respectively. Conclusion: CSCaCO3NP can be termed an excellent non-toxic nanocarrier for curcumin delivery. Hence, curcumin loaded cockle shell derived calcium carbonate nanoparticles (Cur-CSCaCO3NP) could further be assessed for various in vivo and in vitro therapeutic applications against various bone- related ailments.

Aims: The paper has introduced an algorithmic modification of M.L.Das's previous work done of " IoT Mutual Authentication". Background: IoT has proven that if there exists a thing on the earth then it is bound to be connected to the internet to tell its feature on its own. IoT plays a remarkable role in all aspects of our daily lives it covers entertainment, sports, healthcare, education, security, automobiles, industrial as well as home appliances and many more real time applications. To ease our everyday activities, it reinforcing the way people interact with their surroundings. This holistic view brings some major concerns in terms of security and privacy. Objective: The objective of the work is to increase security and protect the algorithm from various attackers so to use with real time application. Methods: In this we have used XoR (Exclusive OR) operation and because of this we can protect the algorithm from DoS attacks, bypass attack, intruder attack and allow user to change password. Conclusion: The proposed work has secured all the connected IoT devices to work inde-pendently and secured because every device has to verify at each step in the IoT system before initiating its operation.