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1. Assessing Nutritional Status in Gastric Cancer Patients after Total versus Subtotal Gastrectomy: Cross-Sectional Study

Author

Akad, Fawzy, primary, Filip, Bogdan, additional, Preda, Cristina, additional, Zugun-Eloae, Florin, additional, Peiu, Sorin Nicolae, additional, Akad, Nada, additional, Crauciuc, Dragos-Valentin, additional, Vatavu, Ruxandra, additional, Gavril, Liviu-Ciprian, additional, Sufaru, Roxana-Florentina, additional, and Mocanu, Veronica, additional

Published
2024
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2. The Link between Obesity and Gastrointestinal Cancers: a Short Review.

Author

AKAD, Fawzy, MOCANU, Veronica, FILIP, Bogdan, POROH, Manuela, OBOROCEANU, Teodor, AKAD, Nada, PEIU, Sorin Nicolae, SCRIPCARIU, Dragos, and SCRIPCARIU, Viorel

Subjects
*GASTROINTESTINAL cancer, *SOMATOMEDIN, *GROWTH factors, *OBESITY, *MORBID obesity
Abstract

Gastrointestinal cancer represents one of the most encountered oncologic pathologies and research studies are performed thoroughly in order to identify the exact causes and possible novel therapies. Obesity is a complex manifestation associated with numerous physiological and primarily molecular changes capable of tackling the behavior of tumoral cells and the nearby or faraway microenvironment. Adipose tissue has been once considered to have limited physiological roles, but in recent years it has been recognized as an active endocrine organ, secreting substances such as growth factors and adipokines. From an epidemiological perspective, obesity -- particularly morbid obesity -- is linked to an unfavorable progression of cancer. A key mechanism that may elucidate the association between obesity and cancer involves the insulin and insulin-like growth factor (IGF-1) pathway, sex hormones, and adipokines. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Kisspeptin Serum Levels in Patients with Endometriosis, New Research Pathways Regarding Female Infertility

Author

AKAD, Mona, SOCOLOV, Razvan, COVALI, Roxana, STAN, Catalina Daniela, CRAUCIUC, Eduard, POPOVICI, Diana, STAN, Cristinel Ionel, AKAD, Fawzy, and SOCOLOV, Demetra

Subjects
Original Paper, General Earth and Planetary Sciences, General Environmental Science
Abstract

Introduction: Endometriosis is defined by the presence of endometrial tissue outside the uterus, therefore leading to a chronic inflammatory reaction, adhesions development, scar tissue and a distorted pelvic female anatomy, most of the times leading to female infertility. Kisspeptin represents a neuropeptide thought to have an essential role in the reproductive functions of both female and male patients. Recently, positive correlations with kisspeptins were noticed in patients diagnosed with endometriosis. Materials and methods: Our study was performed between January 2021-March 2022 in “Elena Doamna” Clinical Hospital of Obstetrics and Gynecology Iasi, Romania. It was a prospective case-control study and included two groups of patients. Both groups consisted in female patients aged between 18 and 45 years, with a body mass index (BMI) between 18,5-30 kg/m2 and similar medical data. Patients in the study group had primary or secondary infertility and endometriosis, while the control group consisted of women with no reproductive issues who had healthy regular menstruations and at least one child. All patients agreed to participate in our study and signed the consent form. Clinical examination, pelvic ultrasound and hormonal dosages were performed. We tested the levels of LH, FSH, kisspeptin, estradiol, prolactin, testosterone, insulin and the glycemic levels in both groups during the follicular phase of their menstrual cycle. Results: We managed to enroll eight patients with endometriosis in the study group and an equal number of patients in the control group. There were significant differences between serum kisspeptin levels, but not also between other hormonal dosages. All patients in the study group had medical evidences of endometriomas but none of them had been subjected to laparoscopy. Conclusions: When considering our study, we regarded the first attribution given to kisspeptin, the one of a metastasis suppressor, and concluded that the high serum values of kisspeptin in patients with endometriosis represented a compensatory-adaptive mechanism needed to constrain future spread of endometriomas in early stages of this pathology.

Published
2022
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4. Sexual Dimorphism in the Buccolingual Dimensions of Permanent Anterior Teeth in the Young Iranian Population

Author

AKAD, Mona, primary, SOCOLOV, Razvan, additional, COVALI, Roxana, additional, STAN, Catalina Daniela, additional, CRAUCIUC, Eduard, additional, POPOVICI, Diana, additional, STAN, Cristinel Ionel, additional, AKAD, Fawzy, additional, SOCOLOV, Demetra, additional, DAVOUDMANESH, Zeinab, additional, FARAJIPOUR, Samaneh, additional, and AZIZI, Nasim, additional

Published
2023
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5. Mesenchymal Stem Cell-Derived Exosomes Modulate Angiogenesis in Gastric Cancer

Author

Akad, Fawzy, primary, Mocanu, Veronica, additional, Peiu, Sorin Nicolae, additional, Scripcariu, Viorel, additional, Filip, Bogdan, additional, Timofte, Daniel, additional, Zugun-Eloae, Florin, additional, Cuciureanu, Magdalena, additional, Hancianu, Monica, additional, Oboroceanu, Teodor, additional, Condur, Laura, additional, and Popa, Radu Florin, additional

Published
2023
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18. Treatments in Patients with Polycystic Ovary Syndrome and Effects on Kisspeptin Serum Levels

Author

AKAD, Mona, SOCOLOV, Demetra, AKAD, Fawzy, COVALI, Roxana, CRAUCIUC, Eduard, STAN, Catalina, STAN, Cristinel, and SOCOLOV, Razvan

Subjects
Original Paper
Abstract

Introduction: Polycystic ovarian syndrome (PCOS) is a common and multifactorial pathology among young women of reproductive age and one of the main causes for female infertility. Most patients are referred to a gynecologist due to specific symptoms such as menstrual irregularities, hirsutism, facial or body acne and inability to obtain a pregnancy. Lately, kisspeptin, a neuropeptide produced in the anterior region of the hypothalamus that seems to modulate the GnRH secretion and therefore the hypothalamic-hypophyseal-ovarian axis (HHO-axis), has been considered responsible for PCOS occurrence. Objectives:The aim of our study was to observe the changes in hormonal balances and kisspeptin serum levels in patients with PCOS after treatment with myo-inositol and vitex. Materials and methods:A prospective clinical study was conducted by us, between 4 January 2021 and 1 March 2022, in “Elena Doamna” Clinical Hospital of Obstetrics and Gynecology, Iasi, Romania. After obtaining the subjects’ informed consent and agreement to participate, we identified 14 patients with PCOS and primary or secondary infertility, who underwent laboratory investigations during the follicular phase of their menstrual cycles, testing for kisspeptin, luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol, testosterone, insulin, blood sugar levels and prolactin. An abdominal-pelvic scan and full body examination were also performed. Patients, in accordance with their gynecologists’ recommendation, preferred a medical therapy consisting of myo-inositol 750 mg/day and vitex 400 mg/day. After three months of treatment, patients agreed to have a second check up to see if any changes occurred. Results:We found significant positive differences when considering kisspeptin, estradiol, FSH and prolactin serum values. There was no significant difference in testosterone and insulin serum levels; on the other hand, we observed an increase in LH serum levels. The mean ovarian volume before treatment was 14.0 for the right ovaries and 13.8 for the left ovaries. After treatment and the recommended lifestyle changes, we noticed a decrease in the mean ovarian volume (13.5 for the right ovaries and 13.4 for the left ovaries). Discussions and conclusions: The etiology of PCOS, which is considered a multifactorial pathology, remains unclear. Multiple studies have been conducted and are still exploring the role of kisspeptin as an etiologic factor for PCOS associated with infertility. Our study showed a decrease in kisspeptin values after the use of myo-inositol and vitex in patients with PCOS, therefore supporting the long-standing theory that kisspeptin might have an essential role in the development of PCOS.

Published
2022

21. Rare Case of Smooth Muscle Tumor of Uncertain Malignant Potential - Clinical Case.

Author

AKAD, Fawzy, FILIP, Bogdan, MOCANU, Veronica, AKAD, Mona, ACATRINEI, Catalina, and SCRIPCARIU, Viorel

Subjects
*SMOOTH muscle tumors, *PHYSICIANS, *MAGNETIC resonance imaging, *DIAGNOSIS, *MYOMETRIUM, *BENIGN tumors
Abstract

Introduction: Smooth muscle tumor of uncertain malignant potential (STUMP) still represents a medical and surgical challenge, being rare and hard to diagnose. Normally STUMP consists in a multitude of uterine tumors that do not meet the current histologic criteria for a specific malignant or benign tumor. Clinical, imagistic and laboratory investigations seem to only raise the presumptive diagnosis in these cases, the diagnosis being confirmed during histological examination of the post hysterectomy/myomectomy specimen. Case report: We present the case of a 50-year-old female patient who was examined for the first time for pelvic pain and sensation of increased pressure in the lower abdomen in June 2020. A gynecology consultation was performed, during which a large uterine mass was felt on vaginal digital examination combined with pelvic palpation. Further pelvic ultrasound examination revealed a voluminous tumor of the left ovary. Then, a magnetic resonance imaging was performed, which showed a large pelvi-abdominal tumor of probable ovarian origin with a mixt tissue type and cystic structure, the presence of pathological abdominal and pelvic lymph nodes, ascites with a suspicion of peritoneal carcinomatosis. The patient was referred to a tertiary center and the multidisciplinary team recommended surgical treatment. A total hysterectomy with bilateral oophorectomy and stadial lymphadenectomy was performed. After surgery, the patient had a favorable evolution and was discharged five days after the intervention in a good health condition. Macroscopic and histological examinations of the biopsy pieces showed morphological aspects of uterine smooth muscles tumors with uncertain malignancy potential/STUMP and multiple uterine leiomyomas. Discussion: Due to the rarity of these tumors, the scientific literature needs to be constantly updated in order to help physicians to correctly identify and treat this pathology. It is highly recommended to identify tumors with a high malignancy potential, so that the follow up will be sufficient to discover and treat recurrences before they become life-threatening. Conclusion: Smooth muscle tumor of uncertain malignant potential remains a difficult diagnosis due to uncertainty between malignancy and benign features. Treatment approaches are difficult in these cases and must always be in accordance with the patients' desire to maintain their reproductive functions and fertility. Recurrence of STUMP has been reported, therefore a close follow up of these patients must always be performed. [ABSTRACT FROM AUTHOR]

Published
2021
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