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6 results on '"ALLARD, J. B."'

1. Inducible transgenic expression in the short-lived fish Nothobranchius furzeri

Author

ALLARD, J. B., KAMEI, H., and DUAN, C.

Subjects
Animals, Genetically Modified, Gene Expression Regulation, Killifishes, Longevity, Animals, Article
Abstract

This study demonstrates inducible transgenic expression in the exceptionally short-lived turquoise killifish Nothobranchius furzeri, which is a useful vertebrate model for ageing research. Transgenic N. furzeri bearing a green fluorescent protein (GFP), containing construct under the control of a heat shock protein 70 promoter were generated, heat shock-induced and reversible GFP expression was demonstrated, and germline transmission of the transgene to the F1 and F2 generations was achieved. The availability of this inducible transgenic expression system will make the study of ageing-related antagonistically pleiotropic genes possible using this unique vertebrate model organism.

Published
2013

4. Unusual lymph node metastases of prostate cancer detected by 18F-fluorocholine PET/CT.

Author

Pinaquy JB, Allard JB, Cornelis F, Pasticier G, and De Clermont H

Subjects
Adenocarcinoma pathology, Aged, Humans, Lymphatic Metastasis diagnostic imaging, Male, Prostatic Neoplasms pathology, Adenocarcinoma diagnostic imaging, Choline analogs & derivatives, Multimodal Imaging, Positron-Emission Tomography, Prostatic Neoplasms diagnostic imaging, Radiopharmaceuticals, Tomography, X-Ray Computed
Abstract

A 65-year-old patient with prostate adenocarcinoma was explored by 18F-fluorocholine (FCH) PET/CT for pretreatment staging because of a high risk of prostate cancer. Images showed multiple foci with increased uptake of 18F-FCH within some pelvic and retroperitoneal lymph nodes, osseous foci (iliac bones and sacrum), and much more unusual, increased uptake foci within some left supraclavicular and left axillary lymph nodes. Owing to the rarity of spread to supraclavicular lymph nodes, surgical removal was performed and revealed prostate cancer metastases.

Published
2015
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5. [Severe liver cytolysis could be a marker of the severity of hemorrhagic dengue: report of two cases].

Author

Guiyedi V, Mattei M, Sommabere A, Karam E, Allard JB, Regouby Y, Okome-Nkoumou M, Lambert de Cursay G, and Abraham BV

Subjects
Adult, Female, Humans, Severe Dengue diagnosis, Severity of Illness Index, Liver Diseases etiology, Severe Dengue complications
Abstract

We report two cases of severe dengue fever in persons returned from stays in endemic areas during the summer outbreak of 2010. Both presented a hemorrhagic syndrome associated with primary hemostasis disorders, neutropenia, and severe hepatic cytolysis without any hepatocellular insufficiency. Three days after hospitalization, the first patient's AST and ALT levels rose to 80 and 12 times the upper reference values respectively, and the second patient's to 12 and 7 times those values. The second also presented signs of hemodynamic shock. Our observations suggest that the combination of severe hepatic cytolysis and hemostatic disorders may be a predictive marker of the severity of dengue fever. The pathophysiologic mechanisms explaining this severity remain unknown.

Published
2012
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6. Diagnosis and treatment of serous otitis media.

Author

Thomas JR and Allard JB

Subjects
Adult, Child, Preschool, Humans, Otitis Media with Effusion therapy, Otitis Media diagnosis, Otitis Media with Effusion diagnosis
Published
1979

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