1. Asymptomatic carriage of plasmodium in urban Dakar : the risk of malaria should not be underestimated
- Author
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Stéphanie Dos Santos, Marion Borderon, Jean-Yves Le Hesran, Nicaise Tuikue Ndam, Abdoulaye Diallo, Azizath Moussiliou, Richard Lalou, Sébastien Oliveau, Alphousseyni Ndonky, Santé de la mère et de l'enfant en milieu tropical : épidémiologie génétique et périnatale, Université Paris Descartes - Paris 5 (UPD5), Laboratoire Population-Environnement-Développement (LPED), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU), Études des Structures, des Processus d’Adaptation et des Changements de l’Espace (ESPACE), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Avignon Université (AU)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Aix Marseille Université (AMU), ANR-07-SEST-0001,ACTU-PALU,Paludisme et diversité de l'environnement urbain africain : un enjeu majeur pour la mise en place des ACT(2007), Institut de Recherche pour le Développement (IRD) - Aix Marseille Université (AMU), Université Nice Sophia Antipolis (UNS), Université Côte d'Azur (UCA) - Université Côte d'Azur (UCA) - Université d'Avignon et des Pays de Vaucluse (UAPV) - Aix Marseille Université (AMU) - Centre National de la Recherche Scientifique (CNRS), ANR-07-SEST-0001, ACTU-PALU, Paludisme et diversité de l'environnement urbain africain : un enjeu majeur pour la mise en place des ACT(2007), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Avignon Université (AU)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), and Université Nice Sophia Antipolis (1965 - 2019) (UNS)
- Subjects
Male ,Aging ,Plasmodium ,Pediatrics ,Non-Clinical Medicine ,Urban Population ,Epidemiology ,[SHS.GEO] Humanities and Social Sciences/Geography ,lcsh:Medicine ,Global Health ,Polymerase Chain Reaction ,urban health ,0302 clinical medicine ,Risk Factors ,030212 general & internal medicine ,Child ,lcsh:Science ,Aged, 80 and over ,Multidisciplinary ,biology ,Carrier state ,[SHS.GEO]Humanities and Social Sciences/Geography ,Middle Aged ,Senegal ,3. Good health ,Infectious Diseases ,Child, Preschool ,Carrier State ,Medicine ,Female ,Public Health ,medicine.symptom ,Research Article ,Adult ,medicine.medical_specialty ,Adolescent ,030231 tropical medicine ,prevalence ,malaria ,Microbiology ,Asymptomatic ,Young Adult ,03 medical and health sciences ,Diagnostic Medicine ,parasitic diseases ,Parasitic Diseases ,medicine ,Animals ,Humans ,Parasites ,Biology ,Aged ,Health Care Policy ,business.industry ,lcsh:R ,Tropical Diseases (Non-Neglected) ,medicine.disease ,biology.organism_classification ,Logistic Models ,Carriage ,Women's Health ,lcsh:Q ,business ,Malaria ,Urban health - Abstract
International audience; Introduction The objective of this study was to measure the rate of asymptomatic carriage of plasmodium in the Dakar region two years after the implementation of new strategies in clinical malaria management. Methodology Between October and December 2008, 2952 households selected in 50 sites of Dakar area, were visited for interviews and blood sampling. Giemsa-stained thick blood smears (TBS) were performed for microscopy in asymptomatic adult women and children aged 2 to 10 years. To ensure the quality of the microscopy, we performed a polymerase chain reaction (PCR) with real time qPCR in all positive TBS by microscopy and in a sample of negative TBS and filter paper blood spots. Results The analysis has concerned 2427 women and 2231 children. The mean age of the women was 35.6 years. The mean age of the children was 5.4 years. The parasite prevalence was 2.01% (49/2427) in women and 2.15% (48/2231) in children. Parasite prevalence varied from one study site to another, ranging from 0 to 7.41%. In multivariate analysis, reporting a malaria episode in 2008 was associated with plasmodium carriage (OR = 2.57, P = 0.002) in women; in children, a malaria episode (OR = 6.19, P
- Published
- 2012