15 results on '"ANTIGLIOMA ACTIVITY"'
Search Results
2. New Hygrocins K–U and Streptophenylpropanamide A and Bioactive Compounds from the Marine-Associated Streptomyces sp. ZZ1956.
- Author
-
Yi, Wenwen, Newaz, Asif Wares, Yong, Kuo, Ma, Mingzhu, Lian, Xiao-Yuan, and Zhang, Zhizhen
- Subjects
STREPTOMYCES ,METHICILLIN-resistant staphylococcus aureus ,BIOACTIVE compounds ,STRUCTURE-activity relationships ,SINGLE crystals - Abstract
Marine-derived Streptomyces actinomycetes are one of the most important sources for the discovery of novel bioactive natural products. This study characterized the isolation, structural elucidation and biological activity evaluation of thirty compounds, including twelve previously undescribed compounds, namely hygrocins K–U (5–13, 17 and 18) and streptophenylpropanamide A (23), from the marine-associated actinomycete Streptomyces sp. ZZ1956. Structures of the isolated compounds were determined by a combination of extensive NMR spectroscopic analyses, HRESIMS data, the Mosher's method, ECD calculations, single crystal X-ray diffraction and comparison with reported data. Hygrocins C (1), D (2), F (4), N (8), Q (11) and R (12), 2-acetamide-6-hydroxy-7-methyl-1,4-naphthoquinone (22), echoside C (27), echoside A (28) and 11,11′-O-dimethylelaiophylin (30) had antiproliferative activity (IC
50 : 0.16–19.39 μM) against both human glioma U87MG and U251 cells with hygrocin C as the strongest active compound (IC50 : 0.16 and 0.35 μM, respectively). The analysis of the structure–activity relationship indicated that a small change in the structures of the naphthalenic ansamycins had significant influence on their antiglioma activities. Hygrocins N (8), O (9), R (12), T (17) and U (18), 2-amino-6-hydroxy-7-methyl-1,4-naphthoquinone (21), 2-acetamide-6-hydroxy-7-methyl-1,4-naphthoquinone (22), 3′-methoxy(1,1′,4′,1″-terphenyl)-2′,6′-diol (26), echoside C (27) and echoside A (28) showed antibacterial activity against methicillin-resistant Staphylococcus aureus and Escherichia coli with MIC values of 3–48 μg/mL. [ABSTRACT FROM AUTHOR]- Published
- 2022
- Full Text
- View/download PDF
3. Antiglioma Natural Products from the Marine-Associated Fungus Penicillium sp. ZZ1750.
- Author
-
Yong, Kuo, Kaleem, Sidra, Ma, Mingzhu, Lian, Xiaoyuan, and Zhang, Zhizhen
- Subjects
- *
PENICILLIUM , *NATURAL products , *NUCLEAR magnetic resonance , *MASS spectrometry , *REACTIVE oxygen species , *OPTICAL rotation - Abstract
Marine-derived Penicillium fungi are one of the most important sources for the discovery of new bioactive natural products. This study characterized the isolation, structures, and antiglioma activities of twelve compounds, including three novel ones—penipyridinone B (1), 11S-(−)-penilloid A (2), and 11R,14E-(+)-penilloid A (3)—from the marine fungus Penicillium sp. ZZ1750. The structures of the novel compounds were determined via extensive nuclear magnetic resonance (NMR) spectroscopic analyses, high-resolution electrospray ionization mass spectroscopy (HRESIMS) data, Mosher's method, optical rotation (OR) calculations, and electronic circular dichroism (ECD) calculations. Penipyridinone B represents the first example of its structural type and showed potent antiglioma activity, with IC50 values of 2.45 μM for U87MG cells and 11.40 μM for U251 cells. The known compounds of questiomycin A (9) and xanthocillin X (10) also showed antiproliferative activity against both U87MG and U251 cells, with IC50 values of 13.65 μM to 22.56 μM. The antiglioma activity of questiomycin A and xanthocillin X may be related to the promotion of reactive oxygen species (ROS) production, the reduction of mitochondrial membrane potential (MMP), and the enhancement of caspase-3 enzyme activity. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
4. Novel metabolites from the Mariana Trench-derived fungus Talaromyces sp. SY2250.
- Author
-
Liu X, Ma M, Ha Y, Wang N, Zhou Y, and Zhang Z
- Abstract
Four previously undescribed compounds talaromyester A ( 1 ) and purpuresters C-E ( 2 - 4 ), together with known purpurester A ( 5 ) and purpuride G ( 6 ), were isolated from the metabolites produced by the Mariana Trench sediment-derived fungus Talaromyces sp. SY2250. Compounds 2 - 5 , two pairs of racemates, were separated on a chiral HPLC column. Structures of the isolated compounds were determined based on their HRESIMS data, extensive NMR spectroscopic analyses, and optical rotation calculations. Purpuride G ( 6 ) showed antiproliferative activity against glioma cells and may be the main active compound responsible for the activity of the crude extract prepared from the culture of Talaromyces sp. SY2250 in rice medium.
- Published
- 2024
- Full Text
- View/download PDF
5. New metabolites (±)-bacillipyrrole A and bacillipyrazine A from the Mariana Trench-associated bacterium Bacillus subtilis SY2101.
- Author
-
Qin, Le, Yong, Kuo, Lian, Xiao-Yuan, and Zhang, Zhizhen
- Abstract
The new (±)-bacillipyrrole A (1) and bacillipyrazine A (2), together with seven known compounds, were isolated from a culture of the Mariana Trench sediment-derived bacterium Bacillus subtilis SY2101 in rice medium. Structures of the new compounds were elucidated by their HRESIMS data and NMR spectroscopic analyses. The known compound 3,5,6-trimethylpyrazine-2-methyl acetate (4) showed antiproliferative activity against human glioma U87MG cells with an IC 50 value of 22.6 ± 2.8 μM. [Display omitted] • Nine metabolites were isolated from the hadal bacterium Bacillus subtilis SY2101. • (±)-Bacillipyrrole A and bacillipyrazine A were characterized as new compounds. • 3,5,6-Trimethylpyrazine-2-methyl acetate (4) showed antiglioma activity. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
6. New Hygrocins K–U and Streptophenylpropanamide A and Bioactive Compounds from the Marine-Associated Streptomyces sp. ZZ1956
- Author
-
Wenwen Yi, Asif Wares Newaz, Kuo Yong, Mingzhu Ma, Xiao-Yuan Lian, and Zhizhen Zhang
- Subjects
marine Streptomyces sp. ZZ1956 ,Streptomycetaceae ,hygrocins K–U ,streptophenylpropanamide A ,structure elucidation ,antiglioma activity ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Marine-derived Streptomyces actinomycetes are one of the most important sources for the discovery of novel bioactive natural products. This study characterized the isolation, structural elucidation and biological activity evaluation of thirty compounds, including twelve previously undescribed compounds, namely hygrocins K–U (5–13, 17 and 18) and streptophenylpropanamide A (23), from the marine-associated actinomycete Streptomyces sp. ZZ1956. Structures of the isolated compounds were determined by a combination of extensive NMR spectroscopic analyses, HRESIMS data, the Mosher’s method, ECD calculations, single crystal X-ray diffraction and comparison with reported data. Hygrocins C (1), D (2), F (4), N (8), Q (11) and R (12), 2-acetamide-6-hydroxy-7-methyl-1,4-naphthoquinone (22), echoside C (27), echoside A (28) and 11,11′-O-dimethylelaiophylin (30) had antiproliferative activity (IC50: 0.16–19.39 μM) against both human glioma U87MG and U251 cells with hygrocin C as the strongest active compound (IC50: 0.16 and 0.35 μM, respectively). The analysis of the structure–activity relationship indicated that a small change in the structures of the naphthalenic ansamycins had significant influence on their antiglioma activities. Hygrocins N (8), O (9), R (12), T (17) and U (18), 2-amino-6-hydroxy-7-methyl-1,4-naphthoquinone (21), 2-acetamide-6-hydroxy-7-methyl-1,4-naphthoquinone (22), 3′-methoxy(1,1′,4′,1″-terphenyl)-2′,6′-diol (26), echoside C (27) and echoside A (28) showed antibacterial activity against methicillin-resistant Staphylococcus aureus and Escherichia coli with MIC values of 3–48 μg/mL.
- Published
- 2022
- Full Text
- View/download PDF
7. Antiglioma Natural Products from the Marine-Associated Fungus Penicillium sp. ZZ1750
- Author
-
Kuo Yong, Sidra Kaleem, Mingzhu Ma, Xiaoyuan Lian, and Zhizhen Zhang
- Subjects
marine Penicillium sp. ZZ1750 ,penipyridinone B ,11S-(−)-penilloid A ,11R,14E-(+)-penilloid A ,structure elucidation ,antiglioma activity ,Organic chemistry ,QD241-441 - Abstract
Marine-derived Penicillium fungi are one of the most important sources for the discovery of new bioactive natural products. This study characterized the isolation, structures, and antiglioma activities of twelve compounds, including three novel ones—penipyridinone B (1), 11S-(−)-penilloid A (2), and 11R,14E-(+)-penilloid A (3)—from the marine fungus Penicillium sp. ZZ1750. The structures of the novel compounds were determined via extensive nuclear magnetic resonance (NMR) spectroscopic analyses, high-resolution electrospray ionization mass spectroscopy (HRESIMS) data, Mosher’s method, optical rotation (OR) calculations, and electronic circular dichroism (ECD) calculations. Penipyridinone B represents the first example of its structural type and showed potent antiglioma activity, with IC50 values of 2.45 μM for U87MG cells and 11.40 μM for U251 cells. The known compounds of questiomycin A (9) and xanthocillin X (10) also showed antiproliferative activity against both U87MG and U251 cells, with IC50 values of 13.65 μM to 22.56 μM. The antiglioma activity of questiomycin A and xanthocillin X may be related to the promotion of reactive oxygen species (ROS) production, the reduction of mitochondrial membrane potential (MMP), and the enhancement of caspase-3 enzyme activity.
- Published
- 2022
- Full Text
- View/download PDF
8. Antiglioma pseurotin A from marine <italic>Bacillus</italic> sp. FS8D regulating tumour metabolic enzymes.
- Author
-
Anjum, Komal, Bi, Hongyun, Chai, Weiyun, Lian, Xiao-Yuan, and Zhang, Zhizhen
- Abstract
Pseurotin A was isolated from a culture of marine
Bacillus sp. FS8D and showed to be active against the proliferation of four different glioma cells with IC50 values of 0.51-29.3 μM. It has been found that pseurotin A downregulated the expression of tumour glycolytic enzymes pyruvate kinase M2 (PKM2) and lactate dehydrogenase 5 (LDH5) and upregulated the expression of pyruvate dehydrogenase beta (PDHB), adenosine triphosphate synthase beta (ATPB) and cytochrome C (Cyto-C), the important regulators for tricarboxylic acid cycle and oxidative phosphorylation. The data suggested that targeting multiple metabolic enzymes might be one of the antiglioma mechanisms of pseurotin A. [ABSTRACT FROM AUTHOR]- Published
- 2018
- Full Text
- View/download PDF
9. New Antiproliferative Compounds against Glioma Cells from the Marine-Sourced Fungus Penicillium sp. ZZ1750
- Author
-
Zhizhen Zhang, Sidra Kaleem, Bin Wu, and Kuo Yong
- Subjects
Circular dichroism ,Aquatic Organisms ,QH301-705.5 ,Pyridones ,Electrospray ionization ,Pharmaceutical Science ,Antineoplastic Agents ,Fungus ,peniresorcinosides A–E ,Mass spectrometry ,Article ,Penicillium sp. ZZ1750 ,Glioma ,Cell Line, Tumor ,Drug Discovery ,penipyridinone A ,medicine ,Humans ,Biology (General) ,marine fungus ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) ,Chemical decomposition ,Cell Proliferation ,biology ,Chemistry ,Brain Neoplasms ,structure elucidation ,Penicillium ,Resorcinols ,biology.organism_classification ,medicine.disease ,antiglioma activity ,penidifarnesylin A ,Single crystal ,Nuclear chemistry - Abstract
Seven novel compounds, namely peniresorcinosides A–E (1–5), penidifarnesylin A (6), and penipyridinone A (7), together with the 11 known ones 8–17, were isolated from a culture of the marine-associated fungus Penicillium sp. ZZ1750 in rice medium. The structures of the new compounds were established based on their high-resolution electrospray ionization mass spectroscopy (HRESIMS) data, extensive nuclear magnetic resonance (NMR) spectroscopic analyses, chemical degradation, Mosher’s method, 13C-NMR calculations, electronic circular dichroism (ECD) calculations, and single crystal X-ray diffraction. Peniresorcinosides A (1) and B (2) are rare glycosylated alkylresorcinols and exhibited potent antiglioma activity, with IC50 values of 4.0 and 5.6 µM for U87MG cells and 14.1 and 9.8 µM for U251 cells, respectively.
- Published
- 2021
10. T Cell Engaging Immunotherapies, Highlighting Chimeric Antigen Receptor (CAR) T Cell Therapy
- Author
-
Nico Callewaert, Elien De Bousser, and Nele Festjens
- Subjects
Cancer Research ,ANTITUMOR-ACTIVITY ,medicine.medical_treatment ,T cell ,Review ,PERIPHERAL-BLOOD ,Immune system ,Cancer immunotherapy ,Antigen ,medicine ,METASTATIC MELANOMA ,TUMOR-INFILTRATING LYMPHOCYTES ,ADOPTIVE IMMUNOTHERAPY ,RC254-282 ,ANTIGLIOMA ACTIVITY ,B cell ,Tumor microenvironment ,chimeric antigen receptor ,business.industry ,GENE-THERAPY ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Biology and Life Sciences ,Immunotherapy ,Chimeric antigen receptor ,CAR ,RECOMBINANT INTERLEUKIN-2 ,PROGNOSTIC VALUE ,medicine.anatomical_structure ,Oncology ,Cancer research ,immunotherapy ,CANCER REGRESSION ,business - Abstract
Simple Summary The ultimate goal of T cell-engaging immunotherapy is to endorse the activity of a person’s own cytotoxic T cells in the tumor microenvironment, finally destroying cancer cells. Several types of immunotherapy are either approved for use or are under study in clinical trials to determine their effectiveness in treating various types of cancer. Chimeric antigen receptor (CAR) T cell therapy is rapidly emerging in the field and has shown unprecedented success in the treatment of hematological malignancies. It entails the collection of a patient’s T cells to genetically engineer them in the lab to express CARs that target surface antigens on tumors to help identify and eradicate the tumor. However, major issues remain to be solved to enable generalized CART cell therapies in the clinic. Novel approaches to tackle these problems are being developed rapidly and are reviewed in this publication. Abstract In the past decade, chimeric antigen receptor (CAR) T cell technology has revolutionized cancer immunotherapy. This strategy uses synthetic CARs to redirect the patient’s own immune cells to recognize specific antigens expressed on the surface of tumor cells. The unprecedented success of anti-CD19 CAR T cell therapy against B cell malignancies has resulted in its approval by the US Food and Drug Administration (FDA) in 2017. However, major scientific challenges still remain to be addressed for the broad use of CAR T cell therapy. These include severe toxicities, limited efficacy against solid tumors, and immune suppression in the hostile tumor microenvironment. Furthermore, CAR T cell therapy is a personalized medicine of which the production is time- and resource-intensive, which makes it very expensive. All these factors drive new innovations to engineer more powerful CAR T cells with improved antitumor activity, which are reviewed in this manuscript.
- Published
- 2021
11. Synthesis and evaluation of new 1,2,3,4-tetrahydroisoquinoline analogs as antiglioma agents.
- Author
-
Patil, Renukadevi, Patil, Shivaputra, Wang, XiangDi, Ma, Fei, Orr, William, Li, Wei, Yates, Charles, Geisert, Eldon, and Miller, Duane
- Abstract
Novel tetrahydroisoquinoline (THI) analogs were designed, synthesized, and their antiglioma activity was evaluated. The results showed that 6,8-dimethoxy-1-(2′-methoxybiphenyl-4-ylmethyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride ( 25) demonstrated improved potency, and selectivity on C6 rat glioma vs cultured rat astrocytes (EC 0.63 μM vs. 10.85 μM) compared to our recent lead molecule EDL-155 (EC 1.5 μM vs. 27.4 μM). The isomers of 25 were isolated using a semi-preparative high-performance liquid chromatography (HPLC) method, and their in vitro biological evaluation revealed that (+) 25 was the most active, and it was nearly 21 fold more potent than (−) 25, suggesting the antiglioma profile is influenced by stereochemical factors. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
12. New Antiproliferative Compounds against Glioma Cells from the Marine-Sourced Fungus Penicillium sp. ZZ1750.
- Author
-
Yong, Kuo, Kaleem, Sidra, Wu, Bin, and Zhang, Zhizhen
- Abstract
Seven novel compounds, namely peniresorcinosides A–E (1–5), penidifarnesylin A (6), and penipyridinone A (7), together with the 11 known ones 8–17, were isolated from a culture of the marine-associated fungus Penicillium sp. ZZ1750 in rice medium. The structures of the new compounds were established based on their high-resolution electrospray ionization mass spectroscopy (HRESIMS) data, extensive nuclear magnetic resonance (NMR) spectroscopic analyses, chemical degradation, Mosher's method,
13 C-NMR calculations, electronic circular dichroism (ECD) calculations, and single crystal X-ray diffraction. Peniresorcinosides A (1) and B (2) are rare glycosylated alkylresorcinols and exhibited potent antiglioma activity, with IC50 values of 4.0 and 5.6 µM for U87MG cells and 14.1 and 9.8 µM for U251 cells, respectively. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
13. Inhibition of cell proliferation and glutathione S-transferase by ascorbyl esters and interferon in mouse glioma.
- Author
-
Naidu, Abhinender, Wiranowska, Marzenna, Kori, Shashidhar, Roetzheim, Kathy, and Kulkarni, Arun
- Abstract
Mouse glioma-26 (G-26) cell line established in this laboratory was used in the study. The in vitro effect of ascorbyl esters, viz., ascorbyl-palmitate (As-P), -stearate (As-S) and mouse interferon-α/β (MulFN-α/β) on the glioma cell viability, proliferation and glutathione S-transferase (GST) activity was investigated. Cell viability and proliferation were examined by colorimetric MTT assay and [H]-thymidine incorporation, respectively. Incubation (24 h) of G-26 cells with As-S, As-P or MulFN-α/β, resulted in a dose dependent decrease in cell viability (IC=125μM As-S; 175μM As-P and 3.6×10 U/ml MulFN-α/β) and proliferation (IC=157μM As-S; 185μM As-P and 3.6×10 U/ml MulFN-α/β). A combined exposure to 175 μM As-S and 800 U/ml of MulFN-α/β resulted in a greater than an additive effect on cell viability and proliferation. The inhibition of cell proliferation/viability by interferon was species specific and was observed only with homologous MulFN-α/β, but not with human interferon-α lymphoblastoid or human interferon-β. Ascorbyl esters inhibited cytosolic GST activity (1-50=15.0 μM As-S and 28.5 μM As-P) towards 1-chloro-2,4-dinitrobenzene in a dose dependent manner. The apparent Ki values for affinity purified GST, deduced from Dixon plots were 0.95 μM and 2.0 μM for As-S and As-P, respectively. Significant inhibition of GST was also observed in the cytosol isolated from G-26 cells exposed to 300 μM As-S or 800 U/ml MulFN-α/β. [ABSTRACT FROM AUTHOR]
- Published
- 1993
- Full Text
- View/download PDF
14. Antiglioma pseurotin A from marine Bacillus sp. FS8D regulating tumour metabolic enzymes.
- Author
-
Anjum K, Bi H, Chai W, Lian XY, and Zhang Z
- Subjects
- Animals, Bacillus metabolism, Carrier Proteins genetics, Carrier Proteins metabolism, Cell Proliferation drug effects, Cytochromes c metabolism, Down-Regulation drug effects, Enzymes genetics, Glioma metabolism, Glycolysis, Humans, Inhibitory Concentration 50, Isoenzymes genetics, Isoenzymes metabolism, L-Lactate Dehydrogenase genetics, L-Lactate Dehydrogenase metabolism, Lactate Dehydrogenase 5, Membrane Proteins genetics, Membrane Proteins metabolism, Mitochondrial Proton-Translocating ATPases metabolism, Pyrrolidinones isolation & purification, Thyroid Hormones genetics, Thyroid Hormones metabolism, Thyroid Hormone-Binding Proteins, Antineoplastic Agents pharmacology, Bacillus chemistry, Enzymes metabolism, Glioma drug therapy, Pyrrolidinones pharmacology
- Abstract
Pseurotin A was isolated from a culture of marine Bacillus sp. FS8D and showed to be active against the proliferation of four different glioma cells with IC
50 values of 0.51-29.3 μM. It has been found that pseurotin A downregulated the expression of tumour glycolytic enzymes pyruvate kinase M2 (PKM2) and lactate dehydrogenase 5 (LDH5) and upregulated the expression of pyruvate dehydrogenase beta (PDHB), adenosine triphosphate synthase beta (ATPB) and cytochrome C (Cyto-C), the important regulators for tricarboxylic acid cycle and oxidative phosphorylation. The data suggested that targeting multiple metabolic enzymes might be one of the antiglioma mechanisms of pseurotin A.- Published
- 2018
- Full Text
- View/download PDF
15. Benz[f]indole誘導体の新規な反応性と生理活性物質合成への展開 : 抗マラリアおよび抗グリオーマ作用を指向した新規化合物の合成
- Author
-
Nyo Mi Swe
- Subjects
antiglioma activity ,求電子置換反応 ,electrophilic substitution reaction ,benz[f]indole ,抗マラリア作用 ,抗グリオーマ作用 ,antimalarial activity - Abstract
平成28年度
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.