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3. Vagus Nerve Stimulation in Ischemic Stroke

Author

Andalib, Sasan, Divani, Afshin A., Ayata, Cenk, Baig, Sheharyar, Arsava, Ethem Murat, Topcuoglu, Mehmet Akif, Cáceres, Eder Leonardo, Parikh, Vinay, Desai, Masoom J., Majid, Arshad, Girolami, Sara, and Di Napoli, Mario

Published
2023
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14. Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies

Author

Harkness, Kirsty, Shaw, Louise, Sword, Jane, Mohd Nor, Azlisham, Sharma, Pankaj, Kelly, Deborah, Harrington, Frances, Randall, Marc, Smith, Matthew, Mahawish, Karim, Elmarim, Abduelbaset, Esisi, Bernard, Cullen, Claire, Nallasivam, Arumug, Price, Christopher, Barry, Adrian, Roffe, Christine, Coyle, John, Hassan, Ahamad, Birns, Jonathan, Cohen, David, Sekaran, Lakshmanan, Parry-Jones, Adrian, Parry, Anthea, Hargroves, David, Proschel, Harald, Datta, Prabel, Darawil, Khaled, Manoj, Aravindakshan, Burn, Mathew, Patterson, Chris, Giallombardo, Elio, Smyth, Nigel, Mansoor, Syed, Anwar, Ijaz, Marsh, Rachel, Ispoglou, Sissi, Chadha, Dinesh, Prabhakaran, Mathuri, Meenakishundaram, Sanjeevikumar, O'Connell, Janice, Scott, Jon, Krishnamurthy, Vinodh, Aghoram, Prasanna, McCormick, Michael, Sprigg, Nikola, O'Mahony, Paul, Cooper, Martin, Choy, Lillian, Wilkinson, Peter, Leach, Simon, Caine, Sarah, Burger, Ilse, Gunathilagan, Gunaratam, Guyler, Paul, Emsley, Hedley, Davis, Michelle, Manawadu, Dulka, Pasco, Kath, Mamun, Maam, Luder, Robert, Sajid, Mahmud, Okwera, James, Warburton, Elizabeth, Saastamoinen, Kari, England, Timothy, Putterill, Janet, Flossman, Enrico, Power, Michael, Dani, Krishna, Mangion, David, Suman, Appu, Corrigan, John, Lawrence, Enas, Vahidassr, Djamil, Shakeshaft, Clare, Brown, Martin, Charidimou, Andreas, Cohen, Hannah, Banerjee, Gargi, Houlden, Henry, White, Mark, Yousry, Tarek, Flossmann, Enrico, Muir, Keith, Gratz, Pascal, Mattle, Heinrich, Panos, Leonidas, Korczyn, Amos, Kliper, Efrat, Maeder, Philippe, Gass, Achim, Pachai, Chahin, Bracoub, Luc, Douste-Blazy, Marie-Yvonne, Fratacci, Marie Dominique, Vicaut, Eric, Sato, Shoichiro, Miwa, Kaori, Fujita, Kyohei, Ide, Toshihiro, Ma, Henry, Ly, John, Singhal, Shaloo, Chandra, Ronil, Slater, Lee-Anne, Soufan, Cathy, Moran, Christopher, Traenka, Christopher, Thilemann, Sebastian, Fladt, Joachim, Gensicke, Henrik, Bonati, Leo, Kim, Beom Joon, Han, Moon-Ku, Kang, Jihoon, Ko, Eunbin, Yang, Mi Hwa, Jang, Myung Suk, Murphy, Sean, Carty, Fiona, Akijian, Layan, Thornton, John, Schembri, Mark, Douven, Elles, Delgado-Mederos, Raquel, Marín, Rebeca, Camps-Renom, Pol, Guisado-Alonso, Daniel, Nuñez, Fidel, Medrano-Martorell, Santiago, Merino, Elisa, Iida, Kotaro, Ikeda, Syuhei, Irie, Hiroyuki, Demirelli, Derya Selcuk, Medanta, Jayesh Modi, Zerna, Charlotte, Hernández, Maria Valdés, Armitage, Paul, Heye, Anna, Muñoz-Maniega, Susana, Sakka, Eleni, Thrippleton, Michael, Dennis, Martin, Beigneux, Ysoline, Silva, Mauro, Venketasubramanian, Narayanaswamy, Ho, Shu Leung, Cheung, Raymond Tak Fai, Chan, Koon Ho, Teo, Kay Cheong, Hui, Edward, Kwan, Joseph Shiu Kwong, Chang, Richard, Tse, Man Yu, Hoi, Chu Peng, Chan, Chung Yan, Chan, Oi Ling, Cheung, Ryan Hoi Kit, Wong, Edmund Ka Ming, Leung, Kam Tat, Tsang, Suk Fung, Ip, Hing Lung, Ma, Sze Ho, Ma, Karen, Fong, Wing Chi, Li, Siu Hung, Li, Richard, Ng, Ping Wing, Wong, Kwok Kui, Liu, Wenyan, Wong, Lawrence, Ramos, Lino, De Schryver, Els, Jöbsis, Joost, van der Sande, Jaap, Brouwers, Paul, Roos, Yvo, Stam, Jan, Bakker, Stef, Verbiest, Henk, Schoonewille, Wouter, Linn, Cisca, Hertzberger, Leopold, van Gemert, Maarten, Berntsen, Paul, Van Dam-Nolen, Dianne, Kooi, M Eline, Van der Lugt, Aad, Koudstaal, Peter, Leff, Alexander, Ward, Nicholas, Nachev, Parashkev, Perry, Richard, Ozkan, Hatice, Mitchell, John, Best, Jonathan G, Ambler, Gareth, Wilson, Duncan, Lee, Keon-Joo, Lim, Jae-Sung, Shiozawa, Masayuki, Koga, Masatoshi, Li, Linxin, Lovelock, Caroline, Chabriat, Hugues, Hennerici, Michael, Wong, Yuen Kwun, Mak, Henry Ka Fung, Prats-Sanchez, Luis, Martínez-Domeño, Alejandro, Inamura, Shigeru, Yoshifuji, Kazuhisa, Arsava, Ethem Murat, Horstmann, Solveig, Purrucker, Jan, Lam, Bonnie Yin Ka, Wong, Adrian, Kim, Young Dae, Song, Tae-Jin, Lemmens, Robin, Eppinger, Sebastian, Gattringer, Thomas, Uysal, Ender, Tanriverdi, Zeynep, Bornstein, Natan M, Ben Assayag, Einor, Hallevi, Hen, Molad, Jeremy, Nishihara, Masashi, Tanaka, Jun, Coutts, Shelagh B, Polymeris, Alexandros, Wagner, Benjamin, Seiffge, David J, Lyrer, Philippe, Algra, Ale, Kappelle, L Jaap, Al-Shahi Salman, Rustam, Jäger, Hans R, Lip, Gregory Y H, Fischer, Urs, El-Koussy, Marwan, Mas, Jean-Louis, Legrand, Laurence, Karayiannis, Christopher, Phan, Thanh, Gunkel, Sarah, Christ, Nicolas, Abrigo, Jill, Leung, Thomas, Chu, Winnie, Chappell, Francesca, Makin, Stephen, Hayden, Derek, Williams, David J, Mess, Werner H, Nederkoorn, Paul J, Barbato, Carmen, Browning, Simone, Wiegertjes, Kim, Tuladhar, Anil M, Maaijwee, Noortje, Guevarra, Anne Cristine, Yatawara, Chathuri, Mendyk, Anne-Marie, Delmaire, Christine, Köhler, Sebastian, van Oostenbrugge, Robert, Zhou, Ying, Xu, Chao, Hilal, Saima, Gyanwali, Bibek, Chen, Christopher, Lou, Min, Staals, Julie, Bordet, Régis, Kandiah, Nagaendran, de Leeuw, Frank-Erik, Simister, Robert, Hendrikse, Jeroen, Kelly, Peter J, Wardlaw, Joanna, Soo, Yannie, Fluri, Felix, Srikanth, Velandai, Calvet, David, Jung, Simon, Kwa, Vincent I H, Engelter, Stefan T, Peters, Nils, Smith, Eric E, Hara, Hideo, Yakushiji, Yusuke, Orken, Dilek Necioglu, Fazekas, Franz, Thijs, Vincent, Heo, Ji Hoe, Mok, Vincent, Veltkamp, Roland, Ay, Hakan, Imaizumi, Toshio, Gomez-Anson, Beatriz, Lau, Kui Kai, Jouvent, Eric, Rothwell, Peter M, Toyoda, Kazunori, Bae, Hee-Joon, Marti-Fabregas, Joan, and Werring, David J

Published
2021
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17. Carotid Artery Perivascular Adipose Tissue Density and Response to Intravenous Tissue Plasminogen Activator in Acute Ischemic Stroke.

Author

Gencer, Elif Sarionder, Yilmaz, Ezgi, Arsava, Ethem Murat, Gocmen, Rahsan, and Topcuoglu, Mehmet Akif

Subjects
CAROTID artery, ADIPOSE tissues, RECEIVER operating characteristic curves, T-test (Statistics), LOGISTIC regression analysis, TISSUE plasminogen activator, DESCRIPTIVE statistics, CAROTID artery stenosis, MANN Whitney U Test, INTRAVENOUS therapy, ISCHEMIC stroke, ANALYSIS of variance, CORONARY angiography, STROKE patients, INFLAMMATION, CONFIDENCE intervals, SENSITIVITY & specificity (Statistics)
Abstract

The importance of Carotid Artery Perivascular Adipose Tissue Density (CAPATd), a parameter that can be readily evaluated on emergency computed tomographic angiography (CTA), in acute stroke has not been adequately clarified. We created exploratory logistic regression models to detect the interaction between the effect of CAPATd and intravenous (IV) tissue plasminogen activator (tPA) in 174 patients (mean age 71 ± 14 years, 94 women) with acute ischemic stroke treated with IV-tPA alone. The CAPATd-average mean (−60.6 ± 18.7 vs −89.8 ± 25.3 Hounsfield units (HU), P =.002) and CAPATd-maximum (14.8 ± 68.9 vs −20.5 ± 39.8 HU, P =.020) values were higher on the ipsilateral side of carotid artery stenosis >60%. CAPATd-maximum ipsilateral emerged as an independent predictor for both modified Rankin's Score 0–2 (52%) [exp(β) =.984] and mRS 0–1 outcome (32%) [exp(β) =.828] in addition to admission National Institutes of Health Stroke Scale, age and carotid plaque burden. CAPATd-maximum ipsilateral was acceptably accurate (Area under the Receiver operating characteristic Curve was.607, P =.0109 for mRS 0–2 and.613, P =.0102 for mRS 0–1). Ipsilateral CAPATd ≥ −25 HU predicted both mRS >3 and mRS >2 with usable sensitivity (59.8% and 66.07%) and specificity (63.6% and 59.68%). In conclusion, higher maximum CAPATd measured on emergency CTA indicates poorer functional prognosis in acute stroke patients treated with IV-tPA. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Acute Stroke Management in Türkiye: Intravenous Tissue Plasminogen Activator and Thrombectomy NöroTek: Türkiye Neurology Single Day Study

Author

Topçuoğlu, Mehmet Akif, primary, Özdemir, Atilla Özcan, additional, Arsava, Ethem Murat, additional, Güneş, Aygül, additional, Aykaç, Özlem, additional, Sarıönder Gencer, Elif, additional, Çabalar, Murat, additional, Yayla, Vildan, additional, Erdoğan, Hacı Ali, additional, Erdoğan, Mücahid, additional, Özdemir Acar, Zeynep, additional, Giray, Semih, additional, Kablan, Yüksel, additional, Tanrıverdi, Zeynep, additional, Yalaz Tekan, Ülgen, additional, Asil, Talip, additional, Akpınar, Çetin Kürşad, additional, Yürekli, Vedat Ali, additional, Acar, Bilgehan, additional, Şirin, Hadiye, additional, Güler, Ayşe, additional, Baydemir, Recep, additional, Akçakoyunlu, Merve, additional, Öcek, Levent, additional, Çetiner, Mustafa, additional, Nazlıel, Bijen, additional, Çağlayan, Hale Batur, additional, Ongun, Nedim, additional, Eren, Alper, additional, Arlıer, Zülfikar, additional, Cenikli, Utku, additional, Gökçe, Mustafa, additional, Bavli, Songül, additional, Yaka, Erdem, additional, Özkul, Ayça, additional, Değirmenci, Bahar, additional, Aluçlu, Ufuk, additional, Togay Işıkay, Canan, additional, Aslanbaba, Eda, additional, Sorgun, Mine, additional, Aytaç, Emrah, additional, Ay, Halil, additional, Kunt, Refik, additional, Şenadım, Songül, additional, Özüm Ünsal, Yaprak, additional, Eşkut, Neslihan, additional, Alioğlu, Zekeriya, additional, Yılmaz, Arda, additional, Genç, Hamit, additional, Yılmaz, Ayşe, additional, Milanoğlu, Aysel, additional, Gürkaş, Erdem, additional, Değirmenci, Eylem, additional, Bektaş, Hesna, additional, İlgezdi, İrem, additional, Bilgiç, Adnan Burak, additional, Akyol, Şenol, additional, Güngör, Levent, additional, Kale, Nilüfer, additional, Çoban, Eda, additional, Yeşilot, Nilüfer, additional, Ekizoğlu, Esme, additional, Kizek, Özgü, additional, Kurşun, Oğuzhan, additional, Kayım Yıldız, Özlem, additional, Bolayır, Aslı, additional, Kısabay, Aysın, additional, Baştan, Birgül, additional, Acar, Zeynep, additional, Niflioğlu, Buket, additional, Güven, Bülent, additional, Kaya, Dilaver, additional, Afşar, Nazire, additional, Yazıcı, Duran, additional, Toplutaş, Eren, additional, Özkan, Esra, additional, İlik, Faik, additional, İnce, Fatma Birsen, additional, Büyükşerbetçi, Gülseren, additional, Önder, Halil, additional, Karadeli, Hasan Hüseyin, additional, Kozak, Hasan Hüseyin, additional, Demirbaş, Hayri, additional, Midi, İpek, additional, Aydın, İsa, additional, Epçeliden, M. Tuncay, additional, Atmaca, Murat Mert, additional, Bakar, Mustafa, additional, Şen, Mustafa, additional, Turgut, Nilda, additional, Keskin, Onur, additional, Akdoğan, Özlem, additional, Emre, Ufuk, additional, Bilgili, Özlem, additional, Bekdik Şirinocak, Pınar, additional, Yevgi, Recep, additional, Yazıcı Akkaş, Sinem, additional, Yoldaş, Tahir, additional, Duman, Taşkın, additional, Özel, Tuğba, additional, Ünal, Ali, additional, Dora, Babür, additional, Atasoy, Tuğrul, additional, Piri Çınar, Bilge, additional, Demir, Tülin, additional, Demir, Turgay, additional, Can, Ufuk, additional, Aslan, Yıldız, additional, Baş, Demet Funda, additional, Şener, Ufuk, additional, Yılmaz, Zahide, additional, Bozdoğan, Zehra, additional, Özdemir, Gökhan, additional, Krespi, Yakup, additional, and Öztürk, Şerefnur, additional

Published
2023
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26. Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies

Author

Harkness, Kirsty, Shaw, Louise, Sword, Jane, Mohd Nor, Azlisham, Sharma, Pankaj, Kelly, Deborah, Harrington, Frances, Randall, Marc, Smith, Matthew, Mahawish, Karim, Elmarim, Abduelbaset, Esisi, Bernard, Cullen, Claire, Nallasivam, Arumug, Price, Christopher, Barry, Adrian, Roffe, Christine, Coyle, John, Hassan, Ahamad, Birns, Jonathan, Cohen, David, Sekaran, Lakshmanan, Parry-Jones, Adrian, Parry, Anthea, Hargroves, David, Proschel, Harald, Datta, Prabel, Darawil, Khaled, Manoj, Aravindakshan, Burn, Mathew, Patterson, Chris, Giallombardo, Elio, Smyth, Nigel, Mansoor, Syed, Anwar, Ijaz, Marsh, Rachel, Ispoglou, Sissi, Chadha, Dinesh, Prabhakaran, Mathuri, Meenakishundaram, Sanjeevikumar, O'Connell, Janice, Scott, Jon, Krishnamurthy, Vinodh, Aghoram, Prasanna, McCormick, Michael, Sprigg, Nikola, O'Mahony, Paul, Cooper, Martin, Choy, Lillian, Wilkinson, Peter, Leach, Simon, Caine, Sarah, Burger, Ilse, Gunathilagan, Gunaratam, Guyler, Paul, Emsley, Hedley, Davis, Michelle, Manawadu, Dulka, Pasco, Kath, Mamun, Maam, Luder, Robert, Sajid, Mahmud, Okwera, James, Warburton, Elizabeth, Saastamoinen, Kari, England, Timothy, Putterill, Janet, Flossman, Enrico, Power, Michael, Dani, Krishna, Mangion, David, Suman, Appu, Corrigan, John, Lawrence, Enas, Vahidassr, Djamil, Shakeshaft, Clare, Brown, Martin, Charidimou, Andreas, Cohen, Hannah, Banerjee, Gargi, Houlden, Henry, White, Mark, Yousry, Tarek, Flossmann, Enrico, Muir, Keith, El-Koussy, Marwan, Gratz, Pascal, Molad, Jeremy, Korczyn, Amos, Kliper, Efrat, Maeder, Philippe, Gass, Achim, Pachai, Chahin, Bracoub, Luc, Douste-Blazy, Marie-Yvonne, Fratacci, Marie Dominique, Vicaut, Eric, Sato, Shoichiro, Miwa, Kaori, Fujita, Kyohei, Ide, Toshihiro, Ma, Henry, Ly, John, Singhal, Shahoo, Chandra, Ronil, Slater, Lee-Anne, Soufan, Cathy, Moran, Christopher, Traenka, Christopher, Thilemann, Sebastian, Fladt, Joachim, Gensicke, Henrik, Bonati, Leo, Kim, Beom Joon, Han, Moon-Ku, Kang, Jihoon, Ko, Eunbin, Yang, Mi Hwa, Jang, Myung Suk, Murphy, Sean, Carty, Fiona, Akijian, Layan, Thornton, John, Schembri, Mark, Douven, Elles, Delgado-Mederos;, Raquel, Marín, Rebeca, Camps-Renom, Pol, Guisado-Alonso, Daniel, Nuñez, Fidel, Medrano-Martorell, Santiago, Merino, Elisa, Iida, Kotaro, Ikeda, Syuhei, Nishihara, Masashi, Irie, Hiroyuki, Demirelli, Derya Selcuk, Medanta, Jayesh Modi, Zerna, Charlotte, Hernández, Maria Valdés, Armitage, Paul, Heye, Anna, Muñoz-Maniega, Susana, Sakka, Eleni, Thrippleton, Michael, Dennis, Martin, Beigneux, Ysoline, Silva, Mauro, Venketasubramanian, Narayanaswamy, Ho, Shu Leung, Cheung, Raymond Tak Fai, Chan, Koon Ho, Teo, Kay Cheong, Hui, Edward, Kwan, Joseph Shiu Kwong, Chang, Richard, Tse, Man Yu, Hoi, Chu Peng, Chan, Chung Yan, Chan, Oi Ling, Cheung, Ryan Hoi Kit, Wong, Edmund Ka Ming, Leung, Kam Tat, Tsang, Suk Fung, Ip, Hing Lung, Ma, Sze Ho, Ma, Karen, Fong, Wing Chi, Li, Siu Hung, Li, Richard, Ng, Ping Wing, Wong, Kwok Kui, Liu, Wenyan, Wong, Lawrence, Ramos, Lino, De Schryver, Els, Jöbsis, Joost, van der Sande, Jaap, Brouwers, Paul, Roos, Yvo, Stam, Jan, Bakker, Stef, Verbiest, Henk, Schoonewille, Wouter, Linn, Cisca, Hertzberger, Leopold, van Gemert, Maarten, Berntsen, Paul, Hendrikse, Jeroen, Nederkoorn, Paul, Mess, Werner, Koudstaal, Peter, Leff, Alexander, Ward, Nicholas, Nachev, Parashkev, Perry, Richard, Ozkan, Hatice, Mitchell, John, Wilson, Duncan, Ambler, Gareth, Lee, Keon-Joo, Lim, Jae-Sung, Shiozawa, Masayuki, Koga, Masatoshi, Li, Linxin, Lovelock, Caroline, Chabriat, Hugues, Hennerici, Michael, Wong, Yuen Kwun, Mak, Henry Ka Fung, Prats-Sánchez, Luis, Martínez-Domeño, Alejandro, Inamura, Shigeru, Yoshifuji, Kazuhisa, Arsava, Ethem Murat, Horstmann, Solveig, Purrucker, Jan, Lam, Bonnie Yin Ka, Wong, Adrian, Kim, Young Dae, Song, Tae-Jin, Schrooten, Maarten, Lemmens, Robin, Eppinger, Sebastian, Gattringer, Thomas, Uysal, Ender, Tanriverdi, Zeynep, Bornstein, Natan M, Assayag, Einor Ben, Hallevi, Hen, Tanaka, Jun, Hara, Hideo, Coutts, Shelagh B, Hert, Lisa, Polymeris, Alexandros, Seiffge, David J, Lyrer, Philippe, Algra, Ale, Kappelle, Jaap, Al-Shahi Salman, Rustam, Jäger, Hans R, Lip, Gregory Y H, Mattle, Heinrich P, Panos, Leonidas D, Mas, Jean-Louis, Legrand, Laurence, Karayiannis, Christopher, Phan, Thanh, Gunkel, Sarah, Christ, Nicolas, Abrigo, Jill, Leung, Thomas, Chu, Winnie, Chappell, Francesca, Makin, Stephen, Hayden, Derek, Williams, David J, Kooi, M Eline, van Dam-Nolen, Dianne H K, Barbato, Carmen, Browning, Simone, Wiegertjes, Kim, Tuladhar, Anil M, Maaijwee, Noortje, Guevarra, Christine, Yatawara, Chathuri, Mendyk, Anne-Marie, Delmaire, Christine, Köhler, Sebastian, van Oostenbrugge, Robert, Zhou, Ying, Xu, Chao, Hilal, Saima, Gyanwali, Bibek, Chen, Christopher, Lou, Min, Staals, Julie, Bordet, Régis, Kandiah, Nagaendran, de Leeuw, Frank-Erik, Simister, Robert, van der Lugt, Aad, Kelly, Peter J, Wardlaw, Joanna M, Soo, Yannie, Fluri, Felix, Srikanth, Velandai, Calvet, David, Jung, Simon, Kwa, Vincent I H, Engelter, Stefan T, Peters, Nils, Smith, Eric E, Yakushiji, Yusuke, Orken, Dilek Necioglu, Fazekas, Franz, Thijs, Vincent, Heo, Ji Hoe, Mok, Vincent, Veltkamp, Roland, Ay, Hakan, Imaizumi, Toshio, Gomez-Anson, Beatriz, Lau, Kui Kai, Jouvent, Eric, Rothwell, Peter M, Toyoda, Kazunori, Bae, Hee-Joon, Marti-Fabregas, Joan, and Werring, David J

Published
2019
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30. Atrial Fibrillation Management in Acute Stroke Patients in Türkiye: Real-life Data from the NöroTek Study

Author

Topçuoğlu, Mehmet Akif, primary, Arsava, Ethem Murat, additional, Özdemir, Atilla Özcan, additional, Aykaç, Özlem, additional, Çetiner, Mustafa, additional, Sarıönder Gencer, Elif, additional, Güneş, Aygül, additional, Krespi, Yakup, additional, Yaka, Erdem, additional, Öcek, Levent, additional, Tanrıverdi, Zeynep, additional, Yalaz Tekan, Ülgen, additional, Özkul, Ayça, additional, Özkan, Esra, additional, Şirin, Hadiye, additional, Güler, Ayşe, additional, Kurşun, Oğuzhan, additional, Kunt, Refik, additional, Cenikli, Utku, additional, Acar, Bilgehan, additional, Kablan, Yüksel, additional, Yılmaz, Ayşe, additional, Işıkay, Canan Togay, additional, Aslanbaba, Eda, additional, Sorgun, Mine, additional, Bektaş, Hesna, additional, Çabalar, Murat, additional, Yayla, Vildan, additional, Erdoğan, Hacı Ali, additional, Gökçe, Mustafa, additional, Bavli, Songül, additional, Ongun, Nedim, additional, Keskin, Ahmet Onur, additional, Akdoğan, Özlem, additional, Emre, Ufuk, additional, Kayım Yıldız, Özlem, additional, Bolayır, Aslı, additional, Akpınar, Çetin Kürşad, additional, Karadeli, Hasan Hüseyin, additional, Özel, Tuğba, additional, Ünal, Ali, additional, Dora, Babür, additional, Arlıer, Zülfikar, additional, Eren, Alper, additional, Milanoğlu, Aysel, additional, Nazliel, Bijen, additional, Batur Çağlayan, Hale, additional, Güven, Bülent, additional, Erdoğan, Mücahid, additional, Özdemir Acar, Zeynep, additional, Bakar, Mustafa, additional, Giray, Semih, additional, Şenadım, Songül, additional, Asil, Talip, additional, Demir, Turgay, additional, Özüm Ünsal, Yaprak, additional, Eşkut, Neslihan, additional, Baştan, Birgül, additional, Acar, Zeynep, additional, Niflioğlu, Buket, additional, Yazıcı, Duran, additional, Aytaç, Emrah, additional, İnce, Fatma Birsen, additional, Ay, Halil, additional, Önder, Halil, additional, Kozak, Hasan Hüseyin, additional, İlgezdi, İrem, additional, Bilgiç, Adnan Burak, additional, Akyol, Şenol, additional, Güngör, Levent, additional, Atmaca, Murat Mert, additional, Şen, Mustafa, additional, Yevgi, Recep, additional, Yazıcı Akkaş, Sinem, additional, Yoldaş, Tahir, additional, Atasoy, H. Tuğrul, additional, Çınar, Bilge Piri, additional, Yılmaz, Arda, additional, Genç, Hamit, additional, Kısabay, Ayşın, additional, İlik, Faik, additional, Demirbaş, Hayri, additional, Midi, İpek, additional, Bekdik Şirinocak, Pınar, additional, Duman, Taşkın, additional, Demir, Tülin, additional, Can, Ufuk, additional, Yürekli, Vedat Ali, additional, Bozdoğan, Zehra, additional, Alioğlu, Zekeriya, additional, Kaya, Dilaver, additional, Afşar, Nazire, additional, Gürkaş, Erdem, additional, Toplutaş, Eren, additional, Değirmenci, Eylem, additional, Büyükşerbetçi, Gülseren, additional, Aydın, İsa, additional, Epçeliden, M. Tuncay, additional, Turgut, Nilda, additional, Kale, Nilüfer, additional, Çoban, Eda, additional, Yeşilot, Nilüfer, additional, Ekizoğlu, Esme, additional, Kizek, Özgü, additional, Bilgili, Özlem, additional, Baydemir, Recep, additional, Akçakoyunlu, Merve, additional, Yılmaz, Zahide, additional, and Öztürk, Şerefnur, additional

Published
2023
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31. Stroke‐Related Visceral Alterations: a Voxel‐Based Neuroanatomic Localization Study

Author

Arsava, Ethem Murat, primary, Chang, Ken, additional, Tawakol, Ahmed, additional, Loggia, Marco L., additional, Goldstein, Joshua N., additional, Brown, James, additional, Park, Kwang‐Yeol, additional, Singhal, Aneesh B., additional, Kalpathy‐Cramer, Jayashree, additional, Sorensen, Alma Gregory, additional, Rosen, Bruce R., additional, Samuels, Martin Allen, additional, and Ay, Hakan, additional

Published
2023
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37. Determinants of in-hospital muscle loss in acute ischemic stroke – Results of the Muscle Assessment in Stroke Study (MASS)

Author

Gungor, Levent, primary, Arsava, Ethem Murat, additional, Guler, Ayse, additional, Togay Isikay, Canan, additional, Aykac, Ozlem, additional, Batur Caglayan, Hale Zeynep, additional, Kozak, Hasan Huseyin, additional, Aydingoz, Ustun, additional, Topcuoglu, Mehmet Akif, additional, Akpinar, Erhan, additional, Argin, Mehmet, additional, Bugrul, Ahmet, additional, Eryildiz, Ezgi Sezer, additional, Giray, Semih, additional, Inanc, Yusuf, additional, Kesen, Sevcihan, additional, Nazliel, Bijen, additional, Ozdemir, Atilla Ozcan, additional, Ozturk, Serefnur, additional, Peynir, Sehripabn, additional, Polat, Ahmet Veysel, additional, Poyraz, Necdet, additional, Sirin, Hadiye, additional, Sorgun, Mine Hayriye, additional, and Uzun, Caglar, additional

Published
2023
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49. Assessment of safety and feasibility of non-invasive vagus nerve stimulation for treatment of acute stroke

Author

Arsava, Ethem Murat, primary, Topcuoglu, Mehmet Akif, additional, Ay, Ilknur, additional, Ozdemir, Atilla Ozcan, additional, Gungor, Ibrahim Levent, additional, Togay Isikay, Canan, additional, Nazliel, Bijen, additional, Kozak, Hasan Huseyin, additional, Ozturk, Serefnur, additional, Yilmaz, İbrahim Arda, additional, Dora, Babur, additional, Ay, Hakan, additional, Unal, Ali, additional, Ozel, Tugba, additional, Sorgun, Mine Hayriye, additional, Bahadır, Eda Aslanbaba, additional, Peker, Elif, additional, Aykac, Ozlem, additional, Mehdiyev, Zaur, additional, Caglayan, Hale Zeynep Batur, additional, Gurses, Asli Akyol, additional, Pektezel, Mehmet Yasir, additional, Yilmaz, Ezgi, additional, Oge, Dogan Dinc, additional, Parlak, Safak, additional, Bugrul, Ahmet, additional, Ozguner, Hilal, additional, Seker, Aysu Cetiner, additional, Ozdemir, Gokhan, additional, Ongun, Gozde, additional, Yilmaz, Sueda Ecem, additional, Ozguncu, Cihat, additional, Turan Isik, Saziye Melike, additional, Ildiz, Omer Faruk, additional, Mammadli, Azer, additional, Yildogan, Aydin Talip, additional, and McClure, Candace, additional

Published
2022
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50. Impact of Cerebral Microbleeds in Stroke Patients with Atrial Fibrillation

Author

Soo, Yannie, Zietz, Annaelle, Yiu, Brian, Mok, Vincent C T, Polymeris, Alexandros A, Seiffge, David, Ambler, Gareth, Wilson, Duncan, Leung, Thomas Wai Hong, Tsang, Suk Fung, Chu, Winnie, Abrigo, Jill, Cheng, Cyrus, Lee, Keon-Joo, Lim, Jae-Sung, Shiozawa, Masayuki, Koga, Masatoshi, Chabriat, Hugues, Hennerici, Michael, Wong, Yuen Kwun, Mak, Henry, Collet, Roger, Inamura, Shigeru, Yoshifuji, Kazuhisa, Arsava, Ethem Murat, Horstmann, Solveig, Purrucker, Jan, Lam, Bonnie Y K, Wong, Adrian, Kim, Young Dae, Song, Tae-Jin, Lemmens, Robin, Eppinger, Sebastian, Gattringer, Thomas, Uysal, Ender, Demirelli, Derya Selçuk, Bornstein, Natan M, Assayag, Einor Ben, Hallevi, Hen, Molad, Jeremy, Nishihara, Masashi, Tanaka, Jun, Coutts, Shelagh B, Kappelle, L Jaap, Salman, Rustam Al-Shahi, Jager, Rolf, Lip, Gregory Y. H., Goeldlin, Martina B, Panos, Leonidas D, Mas, Jean-Louis, Legrand, Laurence, Karayiannis, Chris, Phan, Thanh, Bellut, Maximilian, Chappell, Francesca, Makin, Stephen, Hayden, Derek, Williams, David, van Dam-Nolen, Dianne H K, Nederkoorn, Paul J, Barbato, Carmen, Browning, Simone, Wiegertjes, Kim, Tuladhar, Anil Man, Mendyk, Anne-Marie, Köhler, Sebastian, van Oostenburgge, Robert, Zhou, Ying, Xu, Chao, Hilal, Saima, Gyanwali, Bibek, Chen, Christopher, Lou, Min, Staals, Julie, Bordet, Regis, Kandiah, Nagaendran, de Leeuw, Frank-Erik, Simister, Robert, Hendrikse, Jeroen, Wardlaw, Joanna, Kelly, Peter, Fluri, Felix, Srikanth, Velandai, Calvet, David, Jung, Simon, Kwa, Vincent I H, Smith, Eric E, Hara, Hideo, Yakushiji, Yusuke, Orken, Dilek Necioglu, Fazekas, Franz, Thijs, Vincent, Heo, Ji-Hoe, Veltkamp, Roland, Ay, Hakan, Imaizumi, Toshio, Lau, Kui Kai, Jouvent, Eric, Toyoda, Kazunori, Yoshimura, Sohei, Bae, Hee-Joon, Martí-Fàbregas, Joan, Prats-Sánchez, Luis, Lyrer, Philippe, Best, Jonathan, Werring, David, Engelter, Stefan T, Peters, Nils, Neurology, ACS - Atherosclerosis & ischemic syndromes, and ANS - Neurovascular Disorders

Subjects
All institutes and research themes of the Radboud University Medical Center, Neurology, Neurology (clinical), Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3]
Abstract

Objectives: Cerebral microbleeds are associated with the risks of ischemic stroke and intracranial hemorrhage, causing clinical dilemmas for antithrombotic treatment decisions. We aimed to evaluate the risks of intracranial hemorrhage and ischemic stroke associated with microbleeds in patients with atrial fibrillation treated with vitamin K antagonists, direct oral anticoagulants, antiplatelets, and combination therapy (i.e. concurrent oral anticoagulant and antiplatelet).Methods: We included patients with documented atrial fibrillation from the pooled individual patient data analysis by the Microbleeds International Collaborative Network. Risks of subsequent intracranial hemorrhage and ischemic stroke were compared between patients with and without microbleeds, stratified by antithrombotic use.Results: A total of 7,839 patients were included. The presence of microbleeds was associated with an increased relative risk of intracranial hemorrhage (adjusted hazard ratio [aHR] = 2.74, 95% confidence interval = 1.76-4.26) and ischemic stroke (aHR = 1.29, 95% confidence interval = 1.04-1.59). For the entire cohort, the absolute incidence of ischemic stroke was higher than intracranial hemorrhage regardless of microbleed burden. However, for the subgroup of patients taking combination of anticoagulant and antiplatelet therapy, the absolute risk of intracranial hemorrhage exceeded that of ischemic stroke in those with 2 to 4 microbleeds (25 vs 12 per 1,000 patient-years) and ≥ 11 microbleeds (94 vs 48 per 1,000 patient-years).Interpretation: Patients with atrial fibrillation and high burden of microbleeds receiving combination therapy have a tendency of higher rate of intracranial hemorrhage than ischemic stroke, with potential for net harm. Further studies are needed to help optimize stroke preventive strategies in this high-risk group. ANN NEUROL 2023. Objectives: Cerebral microbleeds are associated with the risks of ischemic stroke and intracranial hemorrhage, causing clinical dilemmas for antithrombotic treatment decisions. We aimed to evaluate the risks of intracranial hemorrhage and ischemic stroke associated with microbleeds in patients with atrial fibrillation treated with vitamin K antagonists, direct oral anticoagulants, antiplatelets, and combination therapy (i.e. concurrent oral anticoagulant and antiplatelet).Methods: We included patients with documented atrial fibrillation from the pooled individual patient data analysis by the Microbleeds International Collaborative Network. Risks of subsequent intracranial hemorrhage and ischemic stroke were compared between patients with and without microbleeds, stratified by antithrombotic use.Results: A total of 7,839 patients were included. The presence of microbleeds was associated with an increased relative risk of intracranial hemorrhage (adjusted hazard ratio [aHR] = 2.74, 95% confidence interval = 1.76-4.26) and ischemic stroke (aHR = 1.29, 95% confidence interval = 1.04-1.59). For the entire cohort, the absolute incidence of ischemic stroke was higher than intracranial hemorrhage regardless of microbleed burden. However, for the subgroup of patients taking combination of anticoagulant and antiplatelet therapy, the absolute risk of intracranial hemorrhage exceeded that of ischemic stroke in those with 2 to 4 microbleeds (25 vs 12 per 1,000 patient-years) and ≥ 11 microbleeds (94 vs 48 per 1,000 patient-years).Interpretation: Patients with atrial fibrillation and high burden of microbleeds receiving combination therapy have a tendency of higher rate of intracranial hemorrhage than ischemic stroke, with potential for net harm. Further studies are needed to help optimize stroke preventive strategies in this high-risk group. ANN NEUROL 2023.

Published
2023

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